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718 |
Umiatin U., Hadisoebroto Dilogo I., Sari P., Kusuma Wijaya S. |
57202292099;57252710600;55776482300;57253327600; |
Histological Analysis of Bone Callus in Delayed Union Model Fracture Healing Stimulated with Pulsed Electromagnetic Fields (PEMF) |
2021 |
Scientifica |
2021 |
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4791172 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114651138&doi=10.1155%2f2021%2f4791172&partnerID=40&md5=bebbcb4fbf1dcad92f29c04e06fd11bf |
Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Umiatin, U., Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia, Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hadisoebroto Dilogo, I., Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sari, P., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kusuma Wijaya, S., Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Delayed union and nonunion fractures are clinical challenges for orthopedic surgeons. The development of fracture complications, such as delayed union and nonunion fractures, is still difficult to predict. Various methods are being investigated to improve fracture healing and prevent complications in patients. There are various methods to promote fracture healing, broadly divided into biological, chemical, and physical methods. One of the most widely used physical methods to promote fracture healing is the pulsed electromagnetic field (PEMF). This study aimed to evaluate the healing process of delayed union fracture after being stimulated by PEMF. Twenty-four rats were randomly divided into two groups: the control group (n = 12) and the PEMF group (n = 12). Delayed union fracture was performed on the left femur of all rats. Subsequently, the PEMF group was given PEMF stimulus with a magnetic field intensity of 1.6 mT and a frequency of 50 Hz for 4 hours/day and 7 days/week. The fracture healing process was evaluated on days 5, 10, 18, and 28 based on the bone callus histology using safranin O fast green (SOFG) staining. The results of the histological analysis showed that bone cartilage was higher in the PEMF group than in the control group throughout the observation period. In addition, the PEMF group had less fibrous tissue at the beginning of the healing. This finding indicates PEMF stimulation has an effect on inducing osteogenesis on fracture healing and reducing the risk of delayed union. © 2021 U. Umiatin et al. |
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Hindawi Limited |
2090908X |
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Article |
Q2 |
474 |
10550 |
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720 |
Hariyanto A.D., Permata T.B.M., Gondhowiardjo S.A. |
57253039400;57197808751;6508327402; |
Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity |
2021 |
Immunological Medicine |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114605951&doi=10.1080%2f25785826.2021.1975228&partnerID=40&md5=dee345614c66584e8dcc9d94211b7f1f |
Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Hariyanto, A.D., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and immune homeostasis preventing autoimmune diseases, minimalize chronic inflammatory diseases by enlisting various immunoregulatory mechanisms. The balance between effector T cells (Teff) and regulator T cells is crucial in determining the outcome of an immune response. Regarding tumors, activation or expansion of TReg cells reduces anti-tumor immunity. TReg cells inhibit the activation of CD4+ and CD8+ T cells and suppress anti-tumor activity in the tumor microenvironment. In addition, TReg cells also promote tumor angiogenesis both directly and indirectly to ensure oxygen and nutrient transport to the tumor. There is accumulating evidence showing a positive result that removing or suppressing TReg cells increases anti-tumor immune response. However, depletion of TReg cells will cause autoimmunity. One strategy to improve or restore tumor immunity is targeted therapy on the dominant effector TReg cells in tumor tissue. Various molecules such as CTLA-4, CD4, CD25, GITR, PD-1, OX40, ICOS are in clinical trials to assess their role in attenuating TReg cells’ function. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Japanese Society of Clinical Immunology. |
anti-tumor immunity; immunotherapy; regulatory T cells; TReg; TReg-targeting therapy |
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Taylor and Francis Ltd. |
25785826 |
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Review |
Q3 |
419 |
11666 |
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721 |
Rahyussalim A.J., Nugroho A., Zufar M.L.L., Fathurrahman I., Kurniawati T. |
55212166100;57211502355;57216349850;57252957500;55213290600; |
Integration of Umbilical Cord Mesenchymal Stem Cell Application in Hydroxyapatite-Based Scaffolds in the Treatment of Vertebral Bone Defect due to Spondylitis Tuberculosis: A Translational Study |
2021 |
Stem Cells International |
2021 |
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9928379 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114598250&doi=10.1155%2f2021%2f9928379&partnerID=40&md5=4e40b6a1b5d793e962718a6b68d67fa0 |
Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nugroho, A., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zufar, M.L.L., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fathurrahman, I., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurniawati, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Vertebral bone defect represents one of the most commonly found skeletal problems in the spine. Progressive increase of vertebral involvement of skeletal tuberculosis (TB) is reported as the main cause, especially in developed countries. Conventional spinal fusion using bone graft has been associated with donor-site morbidity and complications. We reported the utilization of umbilical cord mesenchymal stem cells (UC-MSCs) combined with hydroxyapatite (HA) based scaffolds in treating vertebral bone defect due to spondylitis tuberculosis. Materials and Methods. Three patients with tuberculous spondylitis in the thoracic, thoracolumbar, or lumbar region with vertebral body collapse of more than 50 percent were included. The patient underwent a 2-stage surgical procedure, consisting of debridement, decompression, and posterior stabilization in the first stage followed by anterior fusion using the lumbotomy approach at the second stage. Twenty million UC-MSCs combined with HA granules in 2 cc of saline were transplanted to fill the vertebral bone defect. Postoperative alkaline phosphatase level, quality of life, and radiological healing were evaluated at one-month, three-month, and six-month follow-up. Results. The initial mean ALP level at one-month follow-up was 48.33±8.50 U/L. This value increased at the three-month follow-up but decreased at the six-month follow-up time, 97±8.19 U/L and 90.33±4.16 U/L, respectively. Bone formation of 50-75% of the defect site with minimal fracture line was found. Increased bone formation comprising 75-100% of the total bone area was reported six months postoperation. A total score of the SF-36 questionnaire showed better progression in all 8 domains during the follow-up with the mean total score at six months of 2912.5±116.67 from all patients. Conclusion. Umbilical cord mesenchymal stem cells combined with hydroxyapatite-based scaffold utilization represent a prospective alternative therapy for bone formation and regeneration of vertebral bone defect due to spondylitis tuberculosis. Further clinical investigations are needed to evaluate this new alternative. © 2021 Ahmad Jabir Rahyussalim et al. |
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alkaline phosphatase; hydroxyapatite; adult; Article; bone defect; bone regeneration; clinical article; female; healing; human; male; ossification; quality of life; spinal cord decompression; spine fusion; spine stabilization; surgical approach; surgical debridement; tuberculous spondylitis; umbilical cord mesenchymal stem cell; vertebral bone defect |
Hindawi Limited |
16879678 |
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Article |
Q2 |
1205 |
3287 |
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722 |
Haifa G.Z., Wardoyo S. |
57249982200;57211106608; |
Surgical management in tetralogy of Fallot with rare unilateral pulmonary anomalies: A literature review |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114401204&doi=10.1177%2f02184923211039732&partnerID=40&md5=777078337b7532f398e346223b7685f6 |
Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Haifa, G.Z., Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Wardoyo, S., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Tetralogy of Fallot with unilateral pulmonary anomalies such as the unilateral absence of pulmonary artery or unilateral pulmonary agenesis is an extremely rare complex congenital heart anomaly. There is no established surgical algorithm for tetralogy of Fallot with concomitant unilateral pulmonary anomalies. This condition is still challenging, especially in the surgical field. In this review we also present our experiences in our center, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. This literature review aimed to discuss systematic treatment options and hoped to help the decision-making process when surgeons face these rare anomalies. © The Author(s) 2021. |
Tertralogy of Fallot; unilateral absence of pulmonary artery; unilateral pulmonary agenesis; unilateral pulmonary anomalies |
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SAGE Publications Inc. |
02184923 |
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Review |
Q3 |
203 |
19132 |
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724 |
Gunawan H., Kamilia A., Menaldi S.L., Marissa M., Prakoeswa C.R.S., Alinda M.D., Widasmara D., Basuki S., Anum Q., Ariani T., Mamuaja E.H., Rusyati L.M.M. |
55553742589;57201077194;57192918198;57210795916;57189894608;57202009260;57191841830;57221775070;57246220800;57246220900;57246221000;35724714700; |
Characteristics of grade 2 disability in indonesian children with leprosy: A five-year multicenter retrospective study |
2021 |
Clinical, Cosmetic and Investigational Dermatology |
14 |
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1149 |
1153 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114228929&doi=10.2147%2fCCID.S325858&partnerID=40&md5=d2179cc77df886c28de43e2ca3ed6dd3 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia; Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia; Indonesian College of Dermatology and Venereology, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Soetomo Hospital, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sam Ratulangi, Prof. R. D. Kandou Hospital, Manado, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia |
Gunawan, H., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia, Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Indonesian College of Dermatology and Venereology, Jakarta, Indonesia; Kamilia, A., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin Hospital, Bandung, Indonesia, Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia; Menaldi, S.L., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Indonesian College of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Marissa, M., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prakoeswa, C.R.S., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Indonesian College of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Soetomo Hospital, Surabaya, Indonesia; Alinda, M.D., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Soetomo Hospital, Surabaya, Indonesia; Widasmara, D., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Basuki, S., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Anum, Q., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Ariani, T., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Mamuaja, E.H., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sam Ratulangi, Prof. R. D. Kandou Hospital, Manado, Indonesia; Rusyati, L.M.M., Indonesian Leprosy Study Group – Indonesian Society of Dermatology and Venereology, Jakarta, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana, Bali, Indonesia |
Background: One of the indicators of achieved leprosy control is lower new cases of leprosy with grade 2 disability (G2D), while zero new pediatric case with G2D is one of the targets of The Global Leprosy Strategy. This study aimed to describe the characteristics of leprosy in children with G2D from seven provincial hospitals in Indonesia, spanning a period of five years. Methods: This was a descriptive and retrospective study with cross-sectional design. Data were obtained from the medical records of leprosy-affected children in seven provincial hospitals in Indonesia between January 2014 and December 2019 using a total sampling method. Data obtained include characteristics of patients, clinical manifestations, and profile of leprosy in children with G2D. Results: From the 132 data of childhood leprosy retrieved, male (58.33%), age group of 13– 14 years (47.73%), and borderline tuberculoid leprosy (34.09%) comprised the majority of patients. Most of the patients had anesthetic macules as the initial manifestation. The results showed 20 (15.15%) children had G2D. Hands were the most common site affected (50.00%), manifested as claw hands, contractures, atrophy of thenar and hypothenar muscles, and pseudomutilation. Foot drop was seen in five (62.50%) children, and lagophthalmos was seen in one child with leprosy. Conclusion: This study shows that G2D is observed in 15.15% Indonesian children with leprosy at the time of diagnosis, which mostly occurs on the hands in the form of claw hands. Foot disabilities were also observed, most commonly as foot drop, while lagophthalmos was present with disabilities in the eyes. Disability due to leprosy in children really exists. The commitment of all health care services and related institutions is needed in order to reduce the incidence of disability due to leprosy in children. © 2021 Gunawan et al. |
Children; Grade 2 disability; Leprosy |
adolescent; Article; borderline leprosy; child; claw hand; contracture; cross-sectional study; disability; female; grade 2 disability; human; lagophthalmos; leprosy; major clinical study; male; medical record review; muscle atrophy; peroneus nerve paralysis; preschool child; retrospective study; school child; tuberculoid leprosy |
Dove Medical Press Ltd |
11787015 |
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Article |
Q2 |
730 |
6764 |
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726 |
Kim Y., Ahmed E., Ascher N., Danguilan R., Hooi L.S., Hustrini N.M., Kim Y.H., Kute V., Rosete-Liquete R.M.O., Ma M., Mannon R.B., Nakagawa Y., Od-Erdne L., Ramesh V., Rashid H.U., Thangaraju S., Thwin K.T., Vathsala A., West L., Win K.K., Ahn C., Wong G. |
57194114108;57209626753;35394192500;56073507800;6603696990;57200424892;7410196419;36632470600;6507576169;37034386700;7003807110;57236289600;57236003300;57205980938;7102095343;57192114135;57193627441;7003714214;7103226990;57235723800;7201986669;23974794800; |
Meeting Report: First State of the Art Meeting on Gender Disparity in Kidney Transplantation in the Asia-Pacific |
2021 |
Transplantation |
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1888 |
1891 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113766902&doi=10.1097%2fTP.0000000000003841&partnerID=40&md5=9bfb17e13ffa1ac91810ab03036b4871 |
Department of Internal Medicine, Inje University, Busan Paik Hospital, Busan, South Korea; Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan; Division of Transplant Surgery, University of California San Francisco, San Francisco, CA, United States; National Kidney and Transplant Institute, Manila, Quezon City, Philippines; Department of Nephrology and Medicine, Sultanah Aminah Hospital, Johor Bahru, Malaysia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Inje University, Busan Paik Hospital, Busan, South Korea; Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Gujarat University of Transplantation, Sciences, Ahmedabad, India; National Kidney and Transplant Institute, Philippines; Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong; Division of Nephrology, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Division of Urology, Juntendo University, Tokyo, Japan; Department of Nephrology, First Central Hospital of Mongolia, Organ Transplantation Center, Ulaanbaatar, Mongolia; National Organ and Tissue Transplant Organisation, DGHS, Ministry of Health and Family Welfare, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India; Department of Nephrology, Kidney Foundation Hospital and Research Institute, Dhaka, Bangladesh; Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore; Department of Renal Medicine, University of Medicine (I), Yangon, Myanmar; Division of Nephrology, National University of Singapore, Singapore, Singapore; Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; Department of Nephrology, Specialty Hospital, Yangon, Myanmar; Division of Nephrology, National Medical Center, Seoul, South Korea; Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia; Centre for Renal and Transplant Research, Westmead Hospital, Sydney, NSW, Australia |
Kim, Y., Department of Internal Medicine, Inje University, Busan Paik Hospital, Busan, South Korea; Ahmed, E., Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan; Ascher, N., Division of Transplant Surgery, University of California San Francisco, San Francisco, CA, United States; Danguilan, R., National Kidney and Transplant Institute, Manila, Quezon City, Philippines; Hooi, L.S., Department of Nephrology and Medicine, Sultanah Aminah Hospital, Johor Bahru, Malaysia; Hustrini, N.M., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kim, Y.H., Department of Internal Medicine, Inje University, Busan Paik Hospital, Busan, South Korea; Kute, V., Nephrology and Transplantation, Institute of Kidney Diseases and Research Center, Dr. HL Trivedi Institute of Transplantation Sciences (IKDRC-ITS), Gujarat University of Transplantation, Sciences, Ahmedabad, India; Rosete-Liquete, R.M.O., National Kidney and Transplant Institute, Philippines; Ma, M., Department of Medicine, Queen Mary Hospital, Hong Kong, Hong Kong; Mannon, R.B., Division of Nephrology, Department of Medicine, University of Nebraska Medical Center, Omaha, NE, United States; Nakagawa, Y., Division of Urology, Juntendo University, Tokyo, Japan; Od-Erdne, L., Department of Nephrology, First Central Hospital of Mongolia, Organ Transplantation Center, Ulaanbaatar, Mongolia; Ramesh, V., National Organ and Tissue Transplant Organisation, DGHS, Ministry of Health and Family Welfare, Vardhman Mahavir Medical College, Safdarjung Hospital, New Delhi, India; Rashid, H.U., Department of Nephrology, Kidney Foundation Hospital and Research Institute, Dhaka, Bangladesh; Thangaraju, S., Department of Renal Medicine, Singapore General Hospital, Singapore, Singapore; Thwin, K.T., Department of Renal Medicine, University of Medicine (I), Yangon, Myanmar; Vathsala, A., Division of Nephrology, National University of Singapore, Singapore, Singapore; West, L., Department of Pediatrics, University of Alberta, Edmonton, AB, Canada; Win, K.K., Department of Nephrology, Specialty Hospital, Yangon, Myanmar; Ahn, C., Division of Nephrology, National Medical Center, Seoul, South Korea; Wong, G., Sydney School of Public Health, University of Sydney, Sydney, NSW, Australia, Centre for Renal and Transplant Research, Westmead Hospital, Sydney, NSW, Australia |
[No abstract available] |
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Lippincott Williams and Wilkins |
00411337 |
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34416749 |
Article |
Q1 |
1450 |
2398 |
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727 |
Pratomo I.P., Noor D.R., Kusmardi K., Rukmana A., Paramita R.I., Erlina L., Fadilah F., Gayatri A., Fitriani M., Purnomo T.T.H., Ariane A., Heryanto R., Tedjo A. |
57192904477;57214096801;56966625300;35491487100;54882436900;57190181680;56966708600;57204275086;57233517300;57234248500;57210643323;23392757600;57189320451; |
Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19 |
2021 |
International Journal of Inflammation |
2021 |
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1653392 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113632856&doi=10.1155%2f2021%2f1653392&partnerID=40&md5=37c46cd8f6ff191ba785fa8abb7052a3 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia; Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rukmana, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Erlina, L., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Fadilah, F., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Gayatri, A., Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitriani, M., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Purnomo, T.T.H., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Ariane, A., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia, Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia; Tedjo, A., Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia |
Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-B within the endothelial cells and by inducing proinflammatory cytokine release. Concurrently, XO also converts the superoxide radicals into hydroxyl radicals that further induce inflammatory responses. These conditions will ultimately sum up a hyperinflammation condition commonly dubbed as cytokine storm syndrome (CSS). The expression of proinflammatory cytokines and neutrophil chemokines may be reduced by XO inhibitor, as observed in human respiratory syncytial virus (HRSV)-infected A549 cells. Our review emphasizes that XO may have an essential role as an anti-inflammation therapy for respiratory viral infection, including coronavirus disease 2019 (COVID-19). © 2021 Irandi Putra Pratomo et al. |
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allopurinol; uric acid; xanthine oxidase; airway epithelium cell; antiinflammatory activity; catalysis; coronavirus disease 2019; cytokine release; enzyme activity; human; hypoxia; immunopathology; inflammation; neutrophil; nonhuman; pathogenesis; protein function; protein targeting; Review; RNA virus infection |
Hindawi Limited |
20908040 |
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Review |
Q2 |
1106 |
3761 |
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729 |
Raharjo S.B., Mustika R., Lydia A., Yanni M., Sulastomo H., Zhuhra R.T., Atmadikoesoemah C.A. |
57017880700;57220273147;8451287200;57216309765;57204924380;57220591134;57212145127; |
Trainees' perceptions and expectations of formal academic mentoring during the COVID-19 pandemic in Indonesian cardiology residency programs |
2021 |
Journal of Educational Evaluation for Health Professions |
18 |
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19 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113295810&doi=10.3352%2fJEEHP.2021.18.19&partnerID=40&md5=7733f412708826aa1df71dcc04d870df |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia |
Raharjo, S.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lydia, A., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Yanni, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Sulastomo, H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia; Zhuhra, R.T., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Atmadikoesoemah, C.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: During medical residency programs, physicians develop their professional identities as specialists and encounter high expectations in terms of achieving competencies. The responsibilities of medical trainees include caring for patients, balancing work with personal life, and weathering stress, depression, and burnout. Formal academic mentoring programs strive to ease these burdens. The coronavirus disease 2019 (COVID-19) pandemic has altered the trainee-academic mentor relationship, and solutions are needed to address these challenges. The present study aimed to evaluate the formal academic mentoring process through trainees' perceptions and expectations of formal mentoring programs during COVID-19 in Indonesian cardiology residency programs. Methods: This cross-sectional study used a self-administered online questionnaire to capture trainees' perceptions and expectations regarding academic mentoring programs in 3 cardiology residency programs in Indonesia from October to November 2020. The questionnaire was developed before data collection. Perceptions of the existing mentoring programs were compared with expectations. Results: Responses were gathered from 169 out of 174 residents (response rate, 97.3%). Most trainees reported having direct contact with COVID-19 patients (88.82%). They stated that changes had taken place in the mode and frequency of communication with their academic advisors during the pandemic. Significant differences were found between trainees' perceptions of the existing mentoring programs and their expectations for academic mentoring programs (P<0.001). Conclusion: Despite the challenges of interacting with their academic mentors, trainees still perceived academic mentors as a vital resource. Study programs need to consider trainees' expectations when designing academic mentoring programs. © 2021, Korea Health Personnel Licensing Examination Institute (cc) This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Communication; COVID-19; Indonesia; Internship and residency; Mentoring |
cardiology; cross-sectional study; human; Indonesia; medical education; mentor; mentoring; motivation; pandemic; perception; questionnaire; Cardiology; COVID-19; Cross-Sectional Studies; Humans; Indonesia; Internship and Residency; Mentoring; Mentors; Motivation; Pandemics; Perception; SARS-CoV-2; Surveys and Questionnaires |
Korea Health Personnel Licensing Examination Institute |
19755937 |
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34399567 |
Article |
Q2 |
397 |
12204 |
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730 |
Atmakusuma T.D., Hasibuan F.D., Purnamasari D. |
57216961785;57227028400;36519537700; |
The correlation between iron overload and endocrine function in adult transfusion-dependent beta-thalassemia patients with growth retardation |
2021 |
Journal of Blood Medicine |
12 |
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749 |
753 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113290577&doi=10.2147%2fJBM.S325096&partnerID=40&md5=dd85b4afdd08b0c54b3857a4d69f80f1 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Yarsi Hospital, Jakarta, Indonesia; Endocrine and Metabolic Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hasibuan, F.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Yarsi Hospital, Jakarta, Indonesia; Purnamasari, D., Endocrine and Metabolic Division, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Iron overload is a major problem in patients with transfusion-dependent beta-thalassemia (TDT). Reports on the correlation between iron overload and endocrine function with growth retardation in such a population in Indonesia have not been established. Therefore, this study aims to obtain a profile of iron load and endocrine function of adult transfusion dependent beta-thalassemia patients and their correlation with growth retardation. Methods: A cross-sectional study was performed, involving adult homozygous and HbE beta-thalassemia patients receiving blood transfusions at the Cipto Mangunkusumo Hospital, Jakarta. Iron overload was represented by serum ferritin (FS) and transferrin saturation (TS), while the endocrine function was examined by the Thyroid Stimulating Hormone-sensitive (TSHs), free T4 (fT4), and insulin-like growth factor-1 (IGF-1). The results were analyzed using bivariate analysis plus Pearson and Spearman correlation tests. Results: In general, 58 subjects were selected from 224 adult transfusion dependent beta-thalassemia patients, consisting of 31 males (53.4%) and 27 females (46.6%). Furthermore, their median age was 21 (18–24) years, while the subclinical hypothyroid proportion was 32.7% and low IGF-1 levels were detected in 79.3% of the total population. There was a weak negative correlation between FS and fT4 (Spearman rho=−0.361; p=0.003), as well as IGF-1 (Spearman rho=−0.313; p=0.008), but FS and TSHs had no correlation (Spearman rho=0.074; p=0.29). Also, there was no correlation between ST with TSHs (Spearman rho=0.003; p=0.492), fT4 (Spearman rho=0.018; p=0.448), and IGF-1 (Spearman rho= −0.142; p=0.143). Conclusion: Based on serum ferritin, iron overload is discovered to have a negative correlation with free T4 and insulin-like growth factor-1. © 2021 Atmakusuma et al. |
FT4; IGF-1; Serum ferritin; Transferrin saturation; Transfusion-dependent thalassemia; TSHs |
ferritin; hemoglobin; somatomedin C; thyroid antibody; thyroid stimulating immunoglobulin; thyrotropin; transferrin; adult; Article; body mass; chemiluminescence immunoassay; controlled study; correlation analysis; cross-sectional study; endocrine disease; endocrine function; female; ferritin blood level; free thyroxine index; gene expression; hemoglobin E-beta thalassemia; high performance liquid chromatography; human; human tissue; hypothyroidism; iron binding capacity; iron load; iron overload; major clinical study; male; nuclear magnetic resonance imaging; prevalence; protein expression; subclinical hypothyroidism; thyroid function; transferrin saturation; transfusion dependent thalassemia |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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731 |
Raharjo D.E., Kunadian V. |
57212958767;55390915800; |
Is There a Difference in Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Stable Coronary Artery Disease? |
2021 |
Circulation: Cardiovascular Interventions |
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011013 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113224581&doi=10.1161%2fCIRCINTERVENTIONS.121.011013&partnerID=40&md5=d51bf48934551b00e2a6df5c69fb0e80 |
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cardiothoracic Centre, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom |
Raharjo, D.E., Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kunadian, V., Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, Cardiothoracic Centre, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom |
[No abstract available] |
coronary artery disease; Editorials; heart disease; morbidity; percutaneous coronary intervention |
adverse event; coronary artery bypass graft; coronary artery disease; diagnostic imaging; human; percutaneous coronary intervention; Coronary Artery Bypass; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention |
Lippincott Williams and Wilkins |
19417640 |
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34340524 |
Review |
Q1 |
2621 |
832 |
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