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732 |
Wahyudi I., Tendi W., Rahman F., Situmorang G.R., Rodjani A. |
36341995300;57208641745;57194287568;57190001213;6504653529; |
Minimal invasive treatment in pelvic-ureteric junction obstruction: A comprehensive review |
2021 |
Research and Reports in Urology |
13 |
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573 |
580 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113146330&doi=10.2147%2fRRU.S268569&partnerID=40&md5=f261d4ed92d593ac62f22ee1c4284d26 |
Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wahyudi, I., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tendi, W., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahman, F., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Situmorang, G.R., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pelvic-ureteric junction obstruction (PUJO) is a common condition, and one of the lead causes of hydronephrosis in children. Currently, the gold standard treatment of PUJO is open surgery using the Anderson–Hynes-modified dismembered pyeloplasty technique. However, with the advancement of medical technology, several minimal invasive approaches were developed, including endoscopic, laparoscopic, and robotic approach, from which the best choice of surgical technique was yet to be determined. Considering the advantages and disadvantages of these methods, the recommended option is to tailor the best surgical approach to each individual patient, and to the surgeons’ preference and experience. Considering these recent advances, a new algorithm is proposed to choose the best minimal invasive modalities invasive treatment to treat PUJO. © 2021 Wahyudi et al. |
Anderson–Hynes dismembered pyeloplasty; Hydronephrosis; Minimal invasive; PUJO |
child; endoscopic surgery; human; hydronephrosis; laparoscopic surgery; minimally invasive surgery; open surgery; pyeloplasty; Review; robot assisted surgery; surgeon; surgical approach; ureteropelvic junction obstruction |
Dove Medical Press Ltd |
22532447 |
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Review |
Q2 |
506 |
9983 |
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733 |
Maulani C., C Masulili S.L., Santoso W.D., Soedarsono N., Kusdhany L., Auerkari E.I. |
57205060934;57226076327;6506080422;14049161500;55301180900;10139113000; |
Association of subgingival Epstein-Barr virus and periodontitis |
2021 |
F1000Research |
10 |
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414 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112635068&doi=10.12688%2ff1000research.52624.1&partnerID=40&md5=0f76116d02cb7eb0372cd72bb0c00912 |
Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia |
Maulani, C., Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; C Masulili, S.L., Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Santoso, W.D., Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Kusdhany, L., Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia |
Background: The Epstein-Barr virus (EBV) is gaining interest as a possible agent in the etiology of periodontitis. Previous studies have shown controversy on whether EBV DNA in the subgingival periodontal pockets is associated with periodontitis. The aim of the present study was to seek the potential relationship between EBV and periodontitis. Methods: Data on socio-demographics, oral health, and periodontal health were recorded, and samples were collected from gingival crevicular fluid, using sterile paper point. This case-control study of 118 participants included 59 subjects with severe periodontitis and 59 control subjects with mild periodontitis. The EBV load was determined by quantitative real-time PCR. Results: EBV DNA was detected in 37.3% of the case samples and in 18.6% of the control samples. There was no significant difference in the load of EBV DNA between severe and mild periodontitis (p>0.05). The observed load of EBV DNA was up to 4.55x10 5 copies/mL. The detected EBV DNA was significantly associated with the plaque index and the oral hygiene index (all p<0.05). Conclusions: A significant association was not found, but EBV might contribute to periodontitis. Gingival crevicular fluid is useful for monitoring the EBV load by the real-time PCR technique. Copyright: © 2021 Maulani C et al. |
Epstein-Barr Virus; Gingival Crevicular Fluid; Periodontitis |
virus DNA; case control study; complication; Epstein Barr virus; Epstein Barr virus infection; human; periodontitis; Case-Control Studies; DNA, Viral; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Periodontitis |
NLM (Medline) |
20461402 |
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34316360 |
Article |
Q1 |
1099 |
3793 |
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735 |
Librianto D., Suwarto S., Imran D., Pramukti H., Saleh I., Ipang F., Utami W.S., Aprilya D. |
57192894799;8443626100;57226756146;57223395589;57191511801;57226749417;57226736196;57193710642; |
An extremely rare case of upper thoracic salmonella infection |
2021 |
Orthopedic Research and Reviews |
13 |
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107 |
112 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112502092&doi=10.2147%2fORR.S319616&partnerID=40&md5=02436420140f9c1ad84a7f2eb880eee2 |
Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Department of Neurology, Pondok Indah Hospital, Jakarta, Indonesia |
Librianto, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Suwarto, S., Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Imran, D., Department of Neurology, Pondok Indah Hospital, Jakarta, Indonesia; Pramukti, H., Department of Internal Medicine, Pondok Indah Hospital, Jakarta, Indonesia; Saleh, I., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ipang, F., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Utami, W.S., Jakarta Spine Center, Pondok Indah Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Vertebral osteomyelitis is rare. Finding the right etiological agent is important to administer antibiotic regimen accordingly. The occurrence of this disease in endemic countries raises the susceptibility of a more common infection such as tuberculosis and pyogenic bacteria. Salmonella spp. infection is also common in endemic countries; however, extra-intestinal manifestation is very rare. Methods: We present an extremely rare case of salmonella vertebral osteomyelitis (SVO) in the upper thoracic vertebrae of a 64-year-old patient with history of cardiac surgery and other pre-existing comorbidities. SVO was treated by antibiotics, surgical debridement and spinal stabilization. Results: Three weeks after surgery and intravenous antibiotics, the patient recovered and was discharged without fever and back pain, with excellent motoric improvement. Conclusion: Salmonella infection must be considered to be one of possible etiological agents in patients with suggestive spondylitis in emerging countries, especially in those with comorbidities. © 2021 Librianto et al. |
Osteomyelitis; Salmonella; Spondylitis; Thoracic spine |
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Dove Medical Press Ltd |
11791462 |
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Article |
Q2 |
707 |
7037 |
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736 |
Sulaiman A.S., Gani R.A., Hasan I., Lesmana C.R.A., Kurniawan J., Jasirwan C.O.M., Kalista K.F., Nababan S.H.H., Aprilicia G., Lesmana L.A. |
57216938482;23495930300;12776850800;8977683000;57193251655;55192478000;57200425631;57205443199;57212764287;55920139300; |
Overall Survival of Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation (RFA) Treatment: a Retrospective Cohort Study from Two Referral Hospitals in Indonesia |
2021 |
Journal of Gastrointestinal Cancer |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112279138&doi=10.1007%2fs12029-021-00676-0&partnerID=40&md5=2b5f131ccaeb172f51ae448108c59f48 |
Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra, Jakarta, Indonesia |
Sulaiman, A.S., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gani, R.A., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Lesmana, C.R.A., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kurniawan, J., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Jasirwan, C.O.M., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kalista, K.F., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nababan, S.H.H., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aprilicia, G., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Lesmana, L.A., Digestive Disease and GI Oncology Center, Medistra, Jakarta, Indonesia |
Background: Radiofrequency ablation (RFA) is one of the curative modality therapies commonly used for the early stage of HCC management. Although numerous studies have reported the outcome of RFA around the world, the data regarding the usage of RFA for the early and intermediate stage of HCC remains limited. Hence, the study aimed to report the survival rate of the early and intermediate stage HCC patients who underwent RFA in two tertiary referral hospitals in Jakarta, Indonesia. Methods: A retrospective cohort study was conducted in Cipto Mangunkusumo and Medistra multicenter hospital in Jakarta, Indonesia. The patients with HCC BCLC A and B who underwent RFA treatments between January 2015 to December 2017 were recruited for the study. Baseline characteristics of patients were collected from the medical record. Survival analysis was calculated using the Kaplan Meier. p value result was obtained from the log-rank test. Sub-analysis of factors associated with the survival was also included in this study. Results: There were 62 patients enrolled in this study (32.3% were BCLC A and 67.7% were BCLC B). Forty-six out of 62 patients (74.2%) were reported to have RFA as their first line of treatment, while 12 (25.8%) were reported to have a combination of RFA and other therapy modalities. All these patients were follow-up with an average duration of 27 months. The survival rate of liver cancer due to HCC for 12 and 36 months in patients who received RFA was 82.3% and 57.8%, respectively. Moreover, BCLC staging of liver cancer and response after RFA was significantly associated with survival. Conclusion: RFA still can be used as initial modality therapy nor combination with another therapy for the early and intermediate stage of HCC. BCLC staging and response after RFA had shown to be the independent factors related to survival. © 2021, Springer Science+Business Media, LLC, part of Springer Nature. |
Early stage and intermediate stage of liver cancer; Radiofrequency ablation; Survival rate |
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Springer |
19416628 |
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Article |
Q3 |
473 |
10563 |
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739 |
Kamal A.F., Ramang D.S., Prasetyo M. |
56648996700;57195942455;57192905252; |
Thromboembolism in Malignant Musculoskeletal Tumour: A Literature Review |
2021 |
Advances in Orthopedics |
2021 |
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6678167 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111946705&doi=10.1155%2f2021%2f6678167&partnerID=40&md5=d8f7af261692ce3cb5b68127f841fbe3 |
Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ramang, D.S., Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Malignant musculoskeletal tumour may cause considerable burden to general health. The fast growth combined with the tumour characteristics and its invasion capability resulted in the poor prognosis of malignant musculoskeletal tumour. Malignant musculoskeletal tumour may cause significant disability by destroying normal tissue that plays important role in body kinematics. Thromboembolism, including deep vein thrombosis, pulmonary embolism, and other kinds of venous thromboembolism, is one of the most underestimated complications of musculoskeletal tumour. Normally, thrombosis ensues when pathologic factors overcame the body hemostatic regulatory capabilities, which will predispose the body to the formation of thrombus. Venous thromboembolism in musculoskeletal tumour may develop as a result of interaction between the tumour pathologic capabilities and its interaction with normal bodily functions. In this study, we reviewed the burden of musculoskeletal tumour and its complication on global health. Then, the review will focus on the pathologic and clinical aspect of thromboembolism in malignant musculoskeletal tumour, including pathophysiology, diagnosis, and treatment based on recent findings and literature. © 2021 Achmad Fauzi Kamal et al. |
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acetylsalicylic acid; antineoplastic agent; low molecular weight heparin; tranexamic acid; blood examination; bone metastasis; cancer chemotherapy; clinical feature; drug cost; dynamic contrast-enhanced magnetic resonance imaging; echography; global health; human; locomotor system cancer; Medline; pathophysiology; patient compliance; Review; ScienceDirect; Scopus; SpringerLink; systematic review; thromboembolism; thrombosis prevention; tumor thrombus; venous thromboembolism |
Hindawi Limited |
20903464 |
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Review |
Q2 |
681 |
7334 |
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741 |
Sandora N., Putra M.A., Busro P.W., Ardiansyah, Muttaqin C., Makdinata W., Fitria N.A., Kusuma T.R. |
57204103434;57215605850;57192273817;57223036386;57226442135;57223405655;57148498800;57222897694; |
Preparation of Cell-Seeded Heart Patch In Vitro; Co-Culture of Adipose-Derived Mesenchymal Stem Cell and Cardiomyocytes in Amnion Bilayer Patch |
2021 |
Cardiovascular Engineering and Technology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111590228&doi=10.1007%2fs13239-021-00565-4&partnerID=40&md5=cd6477f9e1ad4b1bf0110d68c68a71fc |
Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia; Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sandora, N., Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia; Putra, M.A., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Busro, P.W., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ardiansyah, Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muttaqin, C., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Makdinata, W., Department of Thoracic Surgery, RSCM, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitria, N.A., Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia; Kusuma, T.R., Institute of Medical Education and Research Indonesia, Jakarta, 10430, Indonesia |
Introduction: Cardiovascular disease is the second killer across the globe, while coronary disease is the major cause. Cell therapy is one alternative to regenerate the infarcted heart wall. Materials and Methods: In this study, the cardiomyogenesis capacity of human adipose stem cells (hAdSC) and human cardiomyocytes (hCardio) cultured in a 3-D biological scaffold (decellularised amnion bilayer) for nine days in a static condition was investigated. The cardiomyogenesis capacity of hAdSC were identified using immunohistochemistry and RT-PCR. The population of the cells isolated from the heart tissue expressed cTnT-1 (13.38 ± 11.38%), cKit (7.85 ± 4.2%), ICAM (85.53 ± 8.69%), PECAM (61.63 ± 7.18%) and VCAM (35.9 ± 9.11%), while from the fat tissue expressed the mesenchymal phenotypes (CD73, CD90, CD105, but not CD45, CD34, CD11b, CD19 and HLA-DR). Two age groups of hAdSC donors were compared, the youngsters (30-40yo) and the elderly (60–70 yo). Results: The co-culture showed that after 5-day incubation, the seeded graft in the hAdSC-30 group had a tube-like appearance while the hAdSC-60 group demonstrated a disorganised pattern, despite of the MSC expressions of the hAdSC-60 were significantly higher. Initial co-culture showed no difference of ATP counts among all groups, however the hAdSC-30 group had the highest ATP count after 9 days culture (p = 0.004). After normalising to the normal myocardium, only the hAdSC-60 group expressed cTnT and MHC, very low, seen during the initial cultivation, but then disappeared. Meanwhile, the hAdSC-30 group expressed α-actinin, MHC and cTnT in the Day-5. The PPAR also was higher in the Day-5 compared to the Day-9 (p < 0.005). Conclusion: Cardiomyogenesis capacity of hAdSC co-cultured with hCardio in a 3-D scaffold taken from the 30–40yo donor showed better morphology and viability than the 60-70yo group, but maintained less than 5 days in this system. © 2021, Biomedical Engineering Society. |
3-D scaffold; Amnion bilayer; Human adipose stem cells; Human cardiomyocytes; Myocardial infarction |
Cell culture; Heart; Stem cells; Tissue; Adipose-derived mesenchymal stem cells; Biological scaffolds; Cardio-vascular disease; Cardiomyogenesis; Coronary disease; Human adipose stem cells; Immunohistochemistry; Static conditions; Scaffolds (biology) |
Springer |
1869408X |
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Article |
Q3 |
541 |
9343 |
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742 |
Paramaiswari W.T., Sidik N.S., Khoeri M.M., Tafroji W., Said W.F., Safari D. |
57221097580;57226416343;55994827400;57118271600;57196217927;23493586700; |
Isolation and Identification of Optochin-Resistant Viridans Group Streptococci from the Sputum Samples of Adult Patients in Jakarta, Indonesia |
2021 |
International Journal of Microbiology |
2021 |
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6646925 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111490612&doi=10.1155%2f2021%2f6646925&partnerID=40&md5=b022c6984c9b9cf061564ebeaeeb4831 |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Biochemistry, Bogor Agricultural University, Bogor, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Paramaiswari, W.T., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sidik, N.S., Department of Biochemistry, Bogor Agricultural University, Bogor, Indonesia; Khoeri, M.M., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Tafroji, W., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Said, W.F., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Aim. To investigate optochin-resistant viridans group streptococci (VGS) strains isolated from the sputum sample of adult patients with different clinical symptoms. Materials and Methods. Optochin-resistant VGS isolates were identified by matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI-TOF MS). recA sequencing was used to confirm identified isolates at the genus level by MALDI-TOF MS. Finding. We identified 79% of tested isolates (148/187) at the species-level identification using the MALDI-TOF MS tool. We identified that the most common species isolated from sputum specimens were S. oralis (44.9%) followed by S. mitis (25.7%), S. infantis (9.1%), S. parasanguinis (7.5%), S. peroris (3.7%), S. anginosus (2.7%), and S. sanguinis (2.1%). Discussion. The S. oralis strains were majority of optochin-resistant VGS isolates obtained from sputum of adult patients in Jakarta, Indonesia. MALDI-TOF MS showed potential for the rapid identification tool to identify optochin-resistant VGS isolates. Although there were discrepancies in identifying isolates at the genus/species level, the performance could be improved by expanding its database. © 2021 Wisiva Tofriska Paramaiswari et al. |
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Hindawi Limited |
1687918X |
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Article |
Q3 |
696 |
7161 |
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744 |
Rinaldi I., Sari R.M., Tedhy V.U., Winston K. |
23475122400;57208474079;57226362042;57224165400; |
Leukapheresis does not improve early survival outcome of acute myeloid leukemia with leukostasis patients – A dual-center retrospective cohort study |
2021 |
Journal of Blood Medicine |
12 |
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623 |
633 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111261844&doi=10.2147%2fJBM.S312140&partnerID=40&md5=ef2e5f0e39b0ea908c07e71bba0bf1a4 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, R.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tedhy, V.U., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Winston, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Leukostasis is a medical emergency with high mortality which often occurs in acute myeloid leukemia patients with hyperleukocytosis. One of the therapies that can be used for leukostasis in acute myeloid leukemia is leukapheresis. However, whether leukapheresis can provide better survival benefit when compared with patients not receiving leukapheresis is still unclear. Hence, we aimed to evaluate the effect of chemotherapy plus leukapheresis combination versus chemotherapy only on 28-day survival of acute myeloid leukemia patients with leukostasis. Methods: This study was a dual-center retrospective cohort using secondary data from medical records collected from November 2018 to March 2019. Inclusion criteria were adult patients aged 18 years old or above, diagnosed with acute leukemia with hyperleukocytosis status defined by WBC count greater than 100,000/uL, and with symptoms of leukostasis. One-month survival analysis was conducted using Kaplan–Meier curve method. Univariate and multivariate analyses were then conducted using Cox proportional hazards model to obtain value of hazard ratio (HR) with a 95% confidence interval (CI). Results: A total of 38 patients were obtained for analysis. The median overall survival was 25 days (95% CI: 17.001–32.999 days) in the chemotherapy only group and 20 days (95% CI: 1.497–38.503) in the chemotherapy with leukapheresis group. The use of leukapheresis did not affect 28-day survival (HR: 1.140; 95% CI: 0.396–3.283; p value: 0.809) and 7-day survival (HR: 1.073; 95% CI: 0.277–4.152; p value: 0.919). In the multivariate analysis, age ≥60 years, blast percentage ≥90%, creatinine ≥1.4 mg/dL, and presence of disseminated intravascular coagulation were associated with worse 28-day survival. Conclusion: AML patients with leukostasis who received both chemotherapy and leuka-pheresis did not have better 28-day survival and 7-day survival when compared with patients receiving chemotherapy only. Old age, high blast percentage, high creatinine, and presence of disseminated intravascular coagulation were prognostic factors for worse 28-day survival. © 2021 Rinaldi et al. |
Chemotherapy; Hyperleukocytosis; Leukapheresis; Leukemia; Leukostasis; Survival |
creatinine; gluconate calcium; hemoglobin; lactate dehydrogenase; vascular cell adhesion molecule 1; acute myeloid leukemia; adult; allogeneic hematopoietic stem cell transplantation; Article; blood transfusion; cancer prognosis; chronic myeloid leukemia; clinical article; cohort analysis; de novo acute myeloid leukemia; dyspnea; female; heart failure; human; hypertension; hypocalcemia; Kaplan Meier method; leukapheresis; leukocyte count; leukocytosis; leukostasis; lymphocyte count; male; mean corpuscular hemoglobin; mean corpuscular volume; mean platelet volume; observational study; overall survival; platelet count; platelet lymphocyte ratio; pneumothorax; red blood cell distribution width; retrospective study; risk factor; thrombocyte aggregation |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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747 |
Rahyussalim A.J., Sahputra R.E., Yanwirasti, Manjas M., Whulanza Y., Kurniawati T., Aprilya D., Zufar M.L.L. |
55212166100;57212460235;56711920400;24473177100;36807053500;55213290600;57193710642;57216349850; |
The effect of mesenchymal stem cell-enriched scaffolds on mmp-8 and tgf-β levels of vertebrae postlaminoplasty in rabbit model |
2021 |
Stem Cells and Cloning: Advances and Applications |
14 |
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27 |
37 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111052490&doi=10.2147%2fSCCAA.S314107&partnerID=40&md5=6b23d4e3b167216975366ce0f5f83ae6 |
Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, IMERI Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Jakarta, Indonesia |
Rahyussalim, A.J., Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, IMERI Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sahputra, R.E., Department of Surgery, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Yanwirasti, Department of Anatomy, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Manjas, M., Department of Surgery, Faculty of Medicine, Universitas Andalas-RSUP M. Djamil, Padang, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering, Universitas Indonesia, Jakarta, Indonesia; Kurniawati, T., Stem Cell and Tissue Engineering Cluster, IMERI Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aprilya, D., Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Zufar, M.L.L., Department of Orthopedics and Traumatology Clinics, Faculty of Medicine, Universitas of Indonesia-Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Some laminoplasty procedures still have restenosis because of bony-bridging failure of the laminar hinge. The present study aimed to determine the effect of mesenchymal stem cell (MSC)-enriched scaffolds on vertebral regeneration after laminoplasty on the basis of the number of osteoblasts, matrix metalloproteinase-8 (MMP-8), and transforming growth factor-beta (TGF-β) levels. Methods: Laminoplasty procedure using the Hirabayashi technique was conducted at the lumbar level in 32 rabbits that were divided into four and three groups of the control (C) and treatment groups, respectively, with different types of laminoplasty spacer (T1, autograft; T2, scaffold; and T3, scaffold with MSCs). Histopathological studies were conducted to calculate the number of osteoblasts and enzyme-linked immunosorbent assay tests to detect MMP-8 and TGF-β 4 weeks after the surgery. Results: The results showed a significant decrease in MMP-8 level in the T3 group compared with that in the control group (p < 0.05). A significant difference exists between the average number of newly formed osteoblasts in the control group compared with that in the T3 group (p < 0.05) with a higher mean blood TGF-β level of all experimental groups compared with that of the control group (p = 0.58). Conclusion: The significant decrease in MMP-8 levels, increase in TGF-β levels, and increased number of osteoblasts on MSC-seeded polylactic acid scaffolds could be useful to support the laminoplasty procedure to prevent restenosis because it was biocompatible and promoted the bone healing process. © 2021 Rahyussalim et al. |
Hirabayashi technique; Laminoplasty; Mesenchymal stem cells; Scaffolds |
enrofloxacin; eosin; hematoxylin; ketoprofen; liquid nitrogen; neutrophil collagenase; polylactic acid; transforming growth factor beta; animal experiment; animal model; animal tissue; Article; autograft; blood sampling; body weight; bone development; cell suspension; cell viability; cervical spine dislocation; controlled study; cryopreservation; enzyme linked immunosorbent assay; follow up; fracture healing; histopathology; inflammation; injury; laminoplasty; mesenchymal stem cell; neoplasm; nonhuman; nutrition; ossification; osteoblast; restenosis; sample size; spine; umbilical cord |
Dove Medical Press Ltd |
11786957 |
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Article |
Q2 |
606 |
8341 |
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750 |
Amalia R., Bustamam A., Yudantha A.R., Victor A.A. |
57226194312;36815737800;55489644900;57191055282; |
Diabetic retinopathy detection and captioning based on lesion features using deep learning approach |
2021 |
Communications in Mathematical Biology and Neuroscience |
2021 |
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59 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110864476&doi=10.28919%2fcmbn%2f5832&partnerID=40&md5=e3e95d1370fc8ff4347362007e9add2e |
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia |
Amalia, R., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Depok, 16424, Indonesia; Yudantha, A.R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia Cipto Mangunkusumo National General Hospital, Jakarta Pusat, 10430, Indonesia |
Diabetic Retinopathy (DR) can lead to vision loss if the patient does not get effective treatment based on the patient’s condition. Early detection is needed to know what an effective treatment for those patients is. For helping ophthalmologists, DR detection methods using computer-based were developed. Ophthalmologists can use the result of the method as a consideration in diagnosing the class of DR. One of the powerful methods is deep learning. The proposed method uses two deep learning architectures, namely Convolutional Neural Network (CNN) and Recurrent Neural Network (RNN), for DR detection. CNN is used to detect DR lesion features, and RNN is used for captioning based on those lesion features. We used three pre-trained CNN models, including AlexNet, VGGNet and GoogleNet, and used Long Short-Term Memory (LSTM) as RNN models. In the image preprocessing, we applied contrast enhancement using Contrast Limited Adaptive Histogram Equalization (CLAHE) and compared the results with those without CLAHE. We have done the training and testing process with a different proportion of data. The experimental results show that our proposed method can detect the lesion features and generate caption with the highest average accuracy of 96.12% for GoogleNet and LSTM with CLAHE and the proportion 70% training data 30% testing data. © 2021 the author(s). |
Convolutional neural network (CNN); Deep learning; Diabetic retinopathy; Long short-term memory (LSTM) |
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SCIK Publishing Corporation |
20522541 |
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Article |
Q4 |
189 |
20081 |
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