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758 |
Auerkari E.I., Maulani C., C. Masulili S.L., Santoso W.D., Soedarsono N., Kusdhany L. |
10139113000;57205060934;57226076327;6506080422;14049161500;55301180900; |
Association of subgingival Epstein-Barr virus and periodontitis |
2021 |
F1000Research |
10 |
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414 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110298348&doi=10.12688%2ff1000research.52624.2&partnerID=40&md5=d21a6f40dceec542152f1e950acf5922 |
Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Maulani, C., Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; C. Masulili, S.L., Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Santoso, W.D., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusdhany, L., Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: The Epstein-Barr virus (EBV) is gaining interest as a possible agent in the etiology of periodontitis. Previous studies have shown controversy on whether EBV DNA in the subgingival periodontal pockets is associated with periodontitis. The present study aimed to seek the potential relationship between EBV and periodontitis. Methods: Samples were taken from gingival crevicular fluid using sterile paper points, and data on sociodemographics, oral health, and periodontal health were recorded. This case-control study of 118 participants included 59 subjects with severe periodontitis and 59 control subjects with mild periodontitis. Quantitative real-time PCR was used to determined EBV load. Results: EBV DNA was detected in 37.3% of the case samples and 18.6% of the control samples. There was no significant difference in a load of EBV DNA between severe and mild periodontitis (p>0.05). The observed load of EBV DNA was up to 4.55x10 5 copies/mL. The detected EBV DNA was significantly associated with the plaque index and the oral hygiene index (p<0.05). Conclusions: Although no significant association was found, EBV may play a role in periodontitis. The real-time PCR methods can be used to monitor the EBV load in gingival crevicular fluid. © 2021 Maulani C et al. |
Epstein-Barr Virus; Gingival Crevicular Fluid; Periodontitis |
adult; aged; Article; case control study; cementoenamel junction; clinical attachment level; controlled study; demography; dental caries; DNA extraction; enzyme immunoassay; Epstein Barr virus; female; gingiva bleeding; gingivitis; health; human; hygiene; lactation; major clinical study; male; mouth hygiene; nonhuman; oral hygiene index; oral hygiene index simplified; peer review; periodontal pocket depth; periodontitis; plaque index; proteomics; real time polymerase chain reaction; regulatory T lymphocyte; tooth root canal |
F1000 Research Ltd |
20461402 |
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34316360 |
Article |
Q1 |
1099 |
3793 |
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759 |
Ertandri L., Hamid A.R.A.H., Saraswati M., Mochtar C.A., Umbas R. |
57226072007;57202054669;57208472364;6506558321;6602634832; |
Open versus percutaneous approach of renal tumor biopsy at cipto mangunkusumo hospital: A single-center experience |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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547 |
551 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110263491&doi=10.3889%2foamjms.2021.6038&partnerID=40&md5=1dba3a8b193172b4b556c059d687c1e8 |
Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pathology Anatomy, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Ertandri, L., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Saraswati, M., Department of Pathology Anatomy, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Umbas, R., Department of Urology, Medical Faculty, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
BACKGROUND: Renal tumor biopsy is beneficial as it is capable of distinguishing between histological types of renal tumor; hence, it plays an important role in deciding the best therapy regimen. AIM: This study aims to evaluate the clinical experiences of renal biopsy in Cipto Mangunkusumo National Referral Hospital (RSCM), with both a percutaneous and open approach. It also aims to analyze the indications, results, intraoperative information, and complications of the two approaches. METHODS: This study was conducted using the retrospective cohort design; meanwhile, data were collected from RSCM from 1990 to 2019. The biopsy sample was taken using percutaneous and open renal biopsy, while comparative analysis was done between the two biopsy approaches. RESULTS: Data were collected from 33 patients that underwent renal biopsy from 1990 to 2019. Majority of the cases were diagnosed as unresectable renal tumor, while histological examination found clear cell carcinoma in most of the cases (73%). Furthermore, the open approach showed longer duration and higher blood loss compared to percutaneous technique with median 60 (30–120) versus 30 (5–60) min (p < 0.001) and 100 (5–650) versus 2 (1–5) ml (p < 0.001), respectively. In general, complications were reported to be low for both techniques. CONCLUSION: Based on the results, percutaneous renal biopsy has similar efficacy and complications rates in tumor sampling for histopathology together with open approach. However, there were significant differences in the duration and blood loss; hence, percutaneous biopsy is more favorable. © 2021 Luki Ertandri, Agus Rizal A. H. Hamid, Meilania Saraswati, Chaidir A. Mochtar, Rainy Umbas. |
Comparative analysis; Complications; Open approach; Percutaneous approach; Renal tumor biopsy |
cefoperazone plus sulbactam; ceftriaxone; adult; aged; Article; bleeding; blood transfusion; cancer staging; clear cell renal cell carcinoma; clinical article; clinical evaluation; cohort analysis; comparative study; female; fine needle aspiration biopsy; general anesthesia; hematuria; histology; histopathology; human; human tissue; kidney biopsy; kidney tumor; local anesthesia; male; needle biopsy; open biopsy; operation duration; operative blood loss; percutaneous biopsy; peroperative complication; real time echography; retrospective study; sepsis; squamous cell carcinoma; transitional cell carcinoma; tumor biopsy; urinary tract infection |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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761 |
Lesmana C.R.A., Paramitha M.S., Gani R.A. |
8977683000;57212562901;23495930300; |
The Role of Interventional Endoscopic Ultrasound in Liver Diseases: What Have We Learnt? |
2021 |
Canadian Journal of Gastroenterology and Hepatology |
2021 |
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9948979 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110213187&doi=10.1155%2f2021%2f9948979&partnerID=40&md5=a038d06d78df9e699aa4a27ead88d0bb |
Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia |
Lesmana, C.R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease and GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Paramitha, M.S., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Gani, R.A., Department of Internal Medicine, Hepatobiliary Division, Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Chronic liver disease (CLD) is still a major problem, where the disease progression will lead to liver cirrhosis (LC) or hepatocellular carcinoma (HCC). Portal hypertension (PH) management and loco-regional therapy for HCC have become the cornerstones in advanced liver disease management. Recently, there are studies looking at the potential role of interventional endoscopic ultrasound (EUS) in liver diseases. EUS may be useful in vascular changes of the digestive wall evaluation, performing dynamic assessment of hemodynamic changes, predicting variceal bleeding and rebleeding risk, and assessing the pharmacological effects. In PH management, EUS-guided vascular therapy - which revolves around glue injection, endovascular coil placement/embolization, and combination of both - has shown promising results. As a diagnostic modality for liver cancer, the implementation of EUS in liver diseases is currently not only limited to liver biopsy (EUS-LB) but also in shear-wave elastography (SWE) and portal pressure gradient measurement, as well as portal vein sampling. The application of EUS-guided radiofrequency ablation (EUS-RFA) and tumor injection can also overcome the limitations shown by both modalities without EUS. Nevertheless, establishing EUS as a firm diagnostic and therapeutic modality is still challenging since the performance of interventional EUS requires high expertise and adequate facilities. © 2021 Cosmas Rinaldi A. Lesmana et al. |
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azygos vein; brachytherapy; chronic liver disease; contrast-enhanced ultrasound; cryotherapy; Doppler flowmetry; elastography; endoscopic ultrasonography; gastrointestinal hemorrhage; human; liver abscess; liver biopsy; liver cirrhosis; liver injury; liver metastasis; nonhuman; paracentesis; peritonitis; portal vein blood pressure; predictive value; radiation exposure; regional perfusion; Review; risk assessment; sclerotherapy; sensitivity and specificity; shear wave elastography; splanchnic blood flow; diagnostic imaging; endoscopic ultrasonography; esophagus varices; interventional ultrasonography; liver cell carcinoma; liver tumor; tumor recurrence; Carcinoma, Hepatocellular; Endosonography; Esophageal and Gastric Varices; Gastrointestinal Hemorrhage; Humans; Liver Neoplasms; Neoplasm R |
Hindawi Limited |
22912789 |
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34258255 |
Review |
Q2 |
921 |
4950 |
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765 |
Tan J.W.C., Chew D.P., Brieger D., Eikelboom J., Montalescot G., Ako J., Kim B.-K., Quek D.K.L., Aitken S.J., Chow C.K., Chour S., Tse H.F., Kaul U., Firdaus I., Kubo T., Liew B.W., Chong T.T., Sin K.Y.K., Yeh H.-I., Buddhari W., Chunhamaneewat N., Hasan F., Fox K.A.A., Nguyen Q.N., Lo S.T.H. |
14829599000;7102026332;7004107910;7006303000;7102302494;6701389098;35189204900;57213290935;57225921713;8871779800;57225956090;7006070805;7102340294;55796864700;57226325834;57205155828;36609879000;57223949258;57225966367;57192991797;6505509528;57225971750;57224650893;39962151600;7401542169; |
2020 Asian Pacific Society of Cardiology Consensus Recommendations on Antithrombotic Management for High-risk Chronic Coronary Syndrome |
2021 |
European Cardiology Review |
16 |
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e26 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109820982&doi=10.15420%2fECR.2020.45&partnerID=40&md5=349f92694e4c018a59343a627d38ced6 |
National Heart Centre, Singapore, Singapore; Sengkang General Hospital, Singapore, Singapore; College of Medicine and Public Health, Flinders University, Adelaide, Australia; Concord Repatriation General Hospital, University of Sydney, Sydney, Australia; McMaster UniversityON, Canada; Sorbonne University, Paris, France; ACTION Study Group, France; Pitié-Salpêtrière University Hospital (AP-HP), Paris, France; Kitasato University and Hospital, Kanagawa, Japan; Yonsei University College of Medicine, South Korea; Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; University of Sydney, Sydney, Australia; Westmead Applied Research Centre, University of Sydney, Sydney, Australia; Westmead Hospital, Sydney, Australia; Calmette Hospital, Phnom Penh, Cambodia; Queen Mary Hospital, University of Hong Kong, Hong Kong; Batra Hospital and Medical Research Center, New Delhi, India; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wakayama Medical University, Wakayama, Japan; Changi General Hospital, Singapore, Singapore; Singapore General Hospital, Singapore, Singapore; MacKay Memorial Hospital, MacKay Medical College, Taipei, Taiwan; King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Siriraj Hospital, Mahidol University, Bangkok, Thailand; Heart & Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; University of Edinburgh, Edinburgh, United Kingdom; Hanoi Medical University, Vietnam National Heart Institute, Hanoi, Viet Nam; Liverpool Hospital, Sydney, Australia |
Tan, J.W.C., National Heart Centre, Singapore, Singapore, Sengkang General Hospital, Singapore, Singapore; Chew, D.P., College of Medicine and Public Health, Flinders University, Adelaide, Australia; Brieger, D., Concord Repatriation General Hospital, University of Sydney, Sydney, Australia; Eikelboom, J., McMaster UniversityON, Canada; Montalescot, G., Sorbonne University, Paris, France, ACTION Study Group, France, Pitié-Salpêtrière University Hospital (AP-HP), Paris, France; Ako, J., Kitasato University and Hospital, Kanagawa, Japan; Kim, B.-K., Yonsei University College of Medicine, South Korea; Quek, D.K.L., Pantai Hospital Kuala Lumpur, Kuala Lumpur, Malaysia; Aitken, S.J., University of Sydney, Sydney, Australia; Chow, C.K., Westmead Applied Research Centre, University of Sydney, Sydney, Australia, Westmead Hospital, Sydney, Australia; Chour, S., Calmette Hospital, Phnom Penh, Cambodia; Tse, H.F., Queen Mary Hospital, University of Hong Kong, Hong Kong; Kaul, U., Batra Hospital and Medical Research Center, New Delhi, India; Firdaus, I., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kubo, T., Wakayama Medical University, Wakayama, Japan; Liew, B.W., Changi General Hospital, Singapore, Singapore; Chong, T.T., Singapore General Hospital, Singapore, Singapore; Sin, K.Y.K., National Heart Centre, Singapore, Singapore; Yeh, H.-I., MacKay Memorial Hospital, MacKay Medical College, Taipei, Taiwan; Buddhari, W., King Chulalongkorn Memorial Hospital, Bangkok, Thailand; Chunhamaneewat, N., Siriraj Hospital, Mahidol University, Bangkok, Thailand; Hasan, F., Heart & Vascular Institute, Cleveland Clinic Abu Dhabi, Abu Dhabi, United Arab Emirates; Fox, K.A.A., University of Edinburgh, Edinburgh, United Kingdom; Nguyen, Q.N., Hanoi Medical University, Vietnam National Heart Institute, Hanoi, Viet Nam; Lo, S.T.H., Liverpool Hospital, Sydney, Australia |
The unique characteristics of patients with chronic coronary syndrome (CCS) in the Asia-Pacific region, heterogeneous approaches because of differences in accesses and resources and low number of patients from the Asia-Pacific region in pivotal studies, mean that international guidelines cannot be routinely applied to these populations. The Asian Pacific Society of Cardiology developed these consensus recommendations to summarise current evidence on the management of CCS and provide recommendations to assist clinicians treat patients from the region. The consensus recommendations were developed by an expert consensus panel who reviewed and appraised the available literature, with focus on data from patients in Asia-Pacific. Consensus statements were developed then put to an online vote. The resulting recommendations provide guidance on the assessment and management of bleeding and ischaemic risks in Asian CCS patients. Furthermore, the selection of long-term antithrombotic therapy is discussed, including the role of single antiplatelet therapy, dual antiplatelet therapy and dual pathway inhibition therapy. © 2021 Radcliffe Group Ltd. All rights reserved. |
Anticoagulant; Antiplatelet; Asia-Pacific; Bleeding; Chronic coronary syndrome; Consensus; Ischaemia |
acetylsalicylic acid; anticoagulant agent; clopidogrel; prasugrel; ticagrelor; age; anticoagulant therapy; Article; Asia; bleeding risk score; brain hemorrhage; cardiac patient; consensus; coronary artery disease; dual antiplatelet therapy; gastrointestinal hemorrhage; heart muscle ischemia; high risk patient; human; percutaneous coronary intervention; thrombosis |
Radcliffe Medical Media |
17583756 |
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Article |
Q2 |
864 |
5422 |
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766 |
Dharma S., Dakota I., Andriantoro H., Firdaus I., Gunawan Limadhy I., Van De Werf F. |
55101301700;55796663700;55037171500;55796864700;57225219360;36048879600; |
Trends in reperfusion therapy for acute ST-segment elevation myocardial infarction in an academic percutaneous coronary intervention center in the metropolitan area of a developing country: Insights from the Jakarta Acute Coronary Syndrome registry |
2021 |
Coronary Artery Disease |
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466 |
467 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109587625&doi=10.1097%2fMCA.0000000000000939&partnerID=40&md5=a4f6e1151d84a687c4d99a6b1f8480c6 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium |
Dharma, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Dakota, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Andriantoro, H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Firdaus, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Indonesia; Gunawan Limadhy, I., Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Van De Werf, F., Department of Cardiovascular Sciences, KU Leuven, Leuven, Belgium |
[No abstract available] |
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adverse event; causality; epidemiology; female; fibrinolytic therapy; heart muscle reperfusion; hospital mortality; human; Indonesia; male; middle aged; mortality; organization and management; percutaneous coronary intervention; preventive health service; procedures; register; ST segment elevation myocardial infarction; time to treatment; total quality management; Causality; Female; Hospital Mortality; Humans; Indonesia; Male; Middle Aged; Myocardial Reperfusion; Percutaneous Coronary Intervention; Preventive Health Services; Quality Improvement; Registries; ST Elevation Myocardial Infarction; Thrombolytic Therapy; Time-to-Treatment |
Lippincott Williams and Wilkins |
09546928 |
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32804781 |
Article |
Q3 |
504 |
10001 |
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767 |
Bachtiar E.W., Bachtiar B.M., Theodorea C.F., Tahapary D.L., Astrella C., Natalina N. |
6507328763;15831189400;57190048861;55944492500;57210793320;57225210620; |
A pilot study of red complex and three genera subgingival microbiome in periodontitis subjects with and without diabetes, evaluated by MinION platform |
2021 |
F1000Research |
10 |
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79 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109577307&doi=10.12688%2ff1000research.28216.3&partnerID=40&md5=83c85f319460a8e5631506acfe142095 |
Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Bachtiar, E.W., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Bachtiar, B.M., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Theodorea, C.F., Department of Oral Biology and Oral Science Research Center, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Astrella, C., Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Natalina, N., Department of Periodontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia |
Background: Subgingival niche is one biofilm habitat containing rich microbiota, which plays an active role in maintaining the health of periodontal tissue and determining host response. As such, a study of changing subgingival biofilms is important for understanding the effect of a systemic condition. In this study, we compared the occurrence of six bacteria cohabiting in the subgingival area of periodontitis subjects, with (DP, n = 8) and without (NDP, n = 4) diabetes. Methods: The six genus and species of targeted bacteria were confirmed by 16S rRNA amplicon sequencing on MinION nanopore platform. Descriptive statistic was used to describe the obtained data. Results: We found that the six genus and species of targeted bacteria were detected but in different quantities in either group's periodontal pocket. Our data showed that Tannerella forsythia was the most abundant species in subgingival biofilms of the DP group of the red complex bacteria. In contrast, Aggregatibacter sp., which belongs to the phylum of proteobacteria, was present at a relatively lower level. In contrast, Fusobacterium sp., which belongs to orange complex bacteria, showed relative similarities in subgingival biofilms of both groups tested, while Veillonella sp., were abundant in the DP groups. Conclusions: Our data show that the diversity of classic periodontopathogens increased in the subgingival niche of periodontitis subjects with diabetes. It is the first study in Indonesia to apply MinION-based, full-length 16S rRNA amplicon sequencing in periodontitis patients with and without diabetes. © 2021 Bachtiar BM et al. |
16S rRNA; Diabetes; MinION; Periodontitis; Red Complex bacteria; Subgingival Microbiome |
RNA 16S; diabetes mellitus; genetics; gingiva; human; Indonesia; microflora; periodontitis; pilot study; Diabetes Mellitus; Gingiva; Humans; Indonesia; Microbiota; Periodontitis; Pilot Projects; RNA, Ribosomal, 16S |
F1000 Research Ltd |
20461402 |
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34249333 |
Article |
Q1 |
1099 |
3793 |
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768 |
Midoen Y.H., Suryandari D.A., Yunaini L., Susworo R., Auerkari E.I., Freisleben H.-J. |
57197805109;6505763338;57192911515;8438653400;10139113000;7003437337; |
Epstein-Barr virus nuclear antigen-1 is useful as therapeutic efficacy marker in serum but not in saliva of nasopharyngeal cancer patients who underwent radiotherapy |
2021 |
ecancermedicalscience |
15 |
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1254 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109546581&doi=10.3332%2fECANCER.2021.1254&partnerID=40&md5=debd5ca3a84a84eabb9d16f1bf92fc2d |
Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia |
Midoen, Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Susworo, R., Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Freisleben, H.-J., Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia |
Introduction: Nasopharyngeal carcinoma (NPC) is a multifactorial disease with genetic, viral, environmental and lifestyle-related risk factors. Epstein-Barr virus (EBV) can promote the oncogenic transformation of an infected cell into malignant. EBV encodes many stimulating products including Epstein-Barr virus nuclear antigen-1 (EBNA-1) which plays a key role in the regulation of gene expression and replication of the genome in the latent period of infection. EBNA-1 in serum and tumour tissue of NPC patients correlates with NPC prognosis. Moreover, the presence of EBV DNA in serum samples from NPC patients' blood circulation can be used as an early marker in the diagnosis of NPC. Objective: The objective of this study was to find effective methods for monitoring the progress of NPC patients undergoing radiotherapy and therapeutic efficacy by observing the changes in EBV DNA in serum and saliva. Methodology: The pre-experimental design compared blood and saliva taken from a pretest and post-test group of NPC patients before and after radiation therapy. The concentration of EBV DNA was measured in the serum and saliva after amplification using quantitative polymerase chain reaction (qPCR) with compatible primers for the EBNA-1 gene. The data were statistically analysed by paired T-test. Results: Highly significant (p = 0.0001) increase in cycle threshold qPCR and decrease in the mean concentration of EBV DNA (p = 0.0001) were observed in serum samples, but no significant changes were observed in saliva. Conclusions: The results suggest that EBV DNA in serum can be used as the gold standard and a marker for monitoring the response to radiation therapy in NPC patients, whereas the examination of EBV DNA from saliva samples is not accurate and thus, not appropriate. © 2021 ecancer Global Foundation. All rights reserved. |
CT; EBNA-1; EBV DNA; NPC; QPCR |
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ecancer Global Foundation |
17546605 |
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Article |
Q3 |
708 |
7022 |
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770 |
Saroyo Y.B., Wibowo N., Irwinda R., Prijanti A.R., Yunihastuti E., Bardosono S., Krisnadi S.R., Permata P.I., Wijaya S., Santawi V.P.A. |
57164888400;15049026900;57190855256;57190863386;57221273925;21933841000;56660648900;57225151181;56685332700;57192917419; |
Oxidative Stress Induced Damage and Early Senescence in Preterm Placenta |
2021 |
Journal of Pregnancy |
2021 |
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9923761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109338598&doi=10.1155%2f2021%2f9923761&partnerID=40&md5=f6580c90345ba249ad3c787766d49062 |
Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Prijanti, A.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Yunihastuti, E., Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Bardosono, S., Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Krisnadi, S.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Permata, P.I., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Wijaya, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Santawi, V.P.A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction. Senescent cells have been demonstrated to release High Mobility Group Box 1 (HMGB1) which induces labor through an inflammatory pathway. This research is aimed at demonstrating whether telomere shortening, proinflammatory HMGB1, and oxidative damage marker 8-OHdG play a role in the placenta of preterm birth in comparison to term birth. Method. A cross-sectional study on 67 full thickness of the placenta obtained from mothers with term and preterm birth. Mothers with clinical signs of infection (fever>38°C, leukocytosis>18000/μL, or abnormal vaginal discharge) and other pregnancy complications were excluded. Real-time polymerase chain reaction was performed to measure T/S ratio and ELISA quantification to measure the amount of HMGB1 and 8-OHdG. Result. A total of 34 placentas from preterm and 33 placentas from term birth were examined. Maternal characteristics were comparable between the two groups. There were no statistical difference of T/S ratio (p=0.181), HMGB1 (p=0.119), and 8-OHdG (p=0.144) between the preterm and term groups. HMGB1 was moderately correlated with 8-OHdG (r=0.314). Telomere T/S ratio of the placenta did not differ between preterm and term labor despite difference in gestational age, suggesting earlier shortening in the preterm group. It is possible that critical telomere length has been achieved in both term and preterm placenta that warrants labor through senescence process. The result of our study also showed that HMGB1 was not correlated to telomere length, due to the fact that HMGB1 is not upregulated until the critical length of telomere for senescence is exhibited. Conclusion. Similar telomere length might be exhibited due to early telomere shortening in preterm birth that mimics the term placenta. The relationship between placental telomere shortening and HMGB1 release remains to be uncovered. Further research is needed to discover the factors leading to early telomere shortening in the placenta of preterm birth. © 2021 Yudianto Budi Saroyo et al. |
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cross-sectional study; female; human; metabolism; newborn; oxidative stress; placenta; pregnancy; prematurity; telomere shortening; Cross-Sectional Studies; Female; Humans; Infant, Newborn; Oxidative Stress; Placenta; Pregnancy; Premature Birth; Telomere Shortening |
Hindawi Limited |
20902727 |
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34258068 |
Article |
Q2 |
828 |
5768 |
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771 |
Victor A.A., Violetta L., Kusumowidagdo G., Pranata R. |
57191055282;57216555090;57200641034;57201973901; |
Pars-plana vitrectomy combined with retinectomy in severe open-globe injuries: A systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109102924&doi=10.1177%2f11206721211029472&partnerID=40&md5=864797e21da1505f0aa16812f4da115e |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Zhejiang University School of Medicine, Hangzhou, China; Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Violetta, L., Zhejiang University School of Medicine, Hangzhou, China, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Kusumowidagdo, G., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Background: This review summarized prophylactic retinectomy technique and its effect on anatomic and functional outcomes in severe open globe injuries (OGIs). Methods: A comprehensive search in PubMed (MEDLINE), Embase, Scopus, and EuropePMC databases was performed up until 8 January 2020. Enrolled studies include case series, studies involving pars plana vitrectomy (PPV) combined with retinectomy in severe penetrating injuries with or without IOFB, perforating injuries, and globe ruptures. Primary outcome was best-corrected visual acuity (BCVA) ⩾20/200 at the end of the study. Secondary outcomes were the rate of proliferative retinopathy (PVR), globe survival rate and retinal reattachment rate. Results: A total of seven studies, involving 275 eyes with severe OGIs, is included in this study. Meta-analysis indicates that final BCVA ⩾20/200 was achieved in 61% (95% CI 49%–73%). Meta-regression analysis showed that improvement was inversely affected by the presence of pre-operative direct macular injury (p = 0.001) and corneal scar (p = 0.015). The proportion of pre-operative BCVA <20/200 was statistically insignificant to the final BCVA ⩾20/200 (p = 0.569). One study showed that the rate is higher in the retinectomy group than the non-retinectomy group (54% vs 11%). Meta-analysis showed that anatomical success can be achieved in 85% (95% CI 78%–91%) of the patients. Meta-regression analysis indicates that the anatomical success did not vary with age (p = 0.653), retinal detachment (p = 0.525), corneal scar (p = 0.596), and lens involvement (p = 0.450). Conclusion: Early PPV combined with retinectomy was associated with acceptable visual improvement and anatomical success. © The Author(s) 2021. |
eye injuries; open-globe injuries; proliferative vitreoretinopathy; Retinectomy; vitrectomy |
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SAGE Publications Ltd |
11206721 |
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Article |
Q2 |
790 |
6120 |
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773 |
Rahman Y., Krisanti R.I.A., Wisnu W., Sitohang I.B.S. |
57225022226;57210797305;57200425452;56734569200; |
The comparison between free thyroxine and thyroid-stimulating hormone levels on melasma severity: A cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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426 |
431 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108964003&doi=10.3889%2foamjms.2021.5952&partnerID=40&md5=b495093253a6b484fb6b524298865e4d |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
Rahman, Y., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Krisanti, R.I.A., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Wisnu, W., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia; Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Salemba, Jakarta, Indonesia |
BACKGROUND: Melasma has been suspected to be linked with levels of thyroid hormone. There is no study that explains the association between thyroid hormone levels with melasma severity. AIM: This study aims to find the discrepancies in the levels of thyroid hormone in varying severity of melasma using two different measurement techniques. METHODS: Subjects were chosen consecutively from the dermatology clinic at RSUPN Dr. Cipto Mangunkusumo hospital. Forty-eight patients participated in this study were categorized into mild melasma and moderate-severe melasma based on modified melasma area and severity index (mMASI) and Janus II measurement. RESULTS: Statistically, mMASI measurement showed no significant association between varying melasma severity with levels of thyroid stimulating hormone and free T4 (FT4), p = 0.375 and p = 0.208, respectively. The Janus II examination using polarized light modality has a weak positive correlation with the serum FT4 level (r = 0.3; p = 0.039). Weak correlation was also found between the two measurement strategies, Janus II and mMASI (r = 0.314; p = 0.03). CONCLUSION: There are no significant differences observed in levels of thyroid hormone between subjects with varying degrees of melasma severity. © 2021 Yusnita Rahman, Roro Inge Ade Krisanti, Wismandari Wisnu, Irma Bernadette S. Sitohang. |
Free T4; Janus II facial analysis system; Melasma; Modified melasma area and severity index; Thyroid-stimulating hormone |
thyrotropin; adult; Article; chloasma; clinical article; cross-sectional study; disease severity; female; free thyroxine index; human; male |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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