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809 |
Prabowo Y., Setiawan I., Kamal A.F., Kodrat E., Labib Zufar M.L. |
56682042400;57223371887;56648996700;57191430080;57223359525; |
Correlation between Prognostic Factors and the Histopathological Response to Neoadjuvant Chemotherapy in Osteosarcoma: A Retrospective Study |
2021 |
International Journal of Surgical Oncology |
2021 |
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8843325 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105720428&doi=10.1155%2f2021%2f8843325&partnerID=40&md5=f2aca94957d4723aa31b40e604603c25 |
Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology Cipto, Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prabowo, Y., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Setiawan, I., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kamal, A.F., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kodrat, E., Department of Anatomical Pathology Cipto, Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Labib Zufar, M.L., Department of Orthopedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background.Multimodality treatment, incorporating neoadjuvant chemotherapy and adjuvant chemotherapy, is the standard management plan for osteosarcoma that increases the overall survival (OS) rate. However, data regarding prognostic factors affecting the histopathological response following neoadjuvant chemotherapy is limited. Patients and Methods. We retrospectively reviewed patients diagnosed with osteosarcoma in our center between 2008 and 2018. We classified patient characteristics according to gender, age, tumor size, site and stage at diagnosis, site of metastasis, type of surgery, necrosis rate based on the Huvos grading system, and the number of neoadjuvant chemotherapy cycles. We divided response to neoadjuvant chemotherapy into poor responder for patients with Huvos grades 1 and 2 and good responder for patients with Huvos grades 3 and 4. We also documented patients' survival and follow-up information. Results. We reviewed 64 patients within 5-65 years of age, dominated by men (62.5%). The distal femur (53.1%) was the most common site of osteosarcoma. Fifteen (23.4%) patients had a good response while 49 (76.6%) patients were poor responders to neoadjuvant chemotherapy based on the Huvos grading system. Based on multivariate analysis, gender (p = 0.012), age (p = 0.029), symptom duration (p = 0.004), and tumor enlargement after neoadjuvant chemotherapy (p < 0.001) were significantly associated with histopathological response. A scoring system was proposed integrating these significant variables (age > 20 years = 1 point, female gender = 1 point, symptom duration > 12 weeks = 1 point, and increased tumor size after neoadjuvant chemotherapy = 2 points). This scoring system divides patients into two groups with a total score of more than two predicting a poor responder to neoadjuvant chemotherapy. Conclusions. Age, gender, symptoms duration, and tumor size after neoadjuvant chemotherapy are the prognostic features that affect the histopathological response to neoadjuvant chemotherapy in patients with osteosarcoma. © 2021 Yogi Prabowo et al. |
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antineoplastic agent; adjuvant chemotherapy; adolescent; adult; aged; bone tumor; child; female; follow up; human; male; middle aged; mortality; neoadjuvant therapy; osteosarcoma; pathology; preschool child; prognosis; retrospective study; survival analysis; young adult; Adolescent; Adult; Aged; Antineoplastic Agents; Bone Neoplasms; Chemotherapy, Adjuvant; Child; Child, Preschool; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoadjuvant Therapy; Osteosarcoma; Prognosis; Retrospective Studies; Survival Analysis; Young Adult |
Hindawi Limited |
20901402 |
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33996154 |
Article |
Q3 |
432 |
11391 |
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810 |
Suwantika A.A., Zakiyah N., Abdulah R., Sitohang V., Tandy G., Anartati A., Hidayatullah T., Herliana P., Hadinegoro S.R. |
55757798100;56073623400;9244834900;57201802658;57208105012;35602938500;35117792500;57203394399;57226218772; |
Cost-Effectiveness and Budget Impact Analyses of Pneumococcal Vaccination in Indonesia |
2021 |
Journal of Environmental and Public Health |
2021 |
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7494965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105700019&doi=10.1155%2f2021%2f7494965&partnerID=40&md5=bbd858611fb710b7cc2cabf814a8c66b |
Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia; Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
Suwantika, A.A., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Zakiyah, N., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Abdulah, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Padjadjaran, Bandung, 45363, Indonesia, Center of Excellence in Higher Education for Pharmaceutical Care Innovation, Universitas Padjadjaran, Bandung, 45363, Indonesia; Sitohang, V., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Tandy, G., Directorate of Health Surveillance and Quarantine, Directorate General of Disease Prevention and Control, Ministry of Health, Jakarta, 12750, Indonesia; Anartati, A., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hidayatullah, T., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Herliana, P., Clinton Health Access Initiative, Jakarta, 10450, Indonesia; Hadinegoro, S.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia |
As a country with the high number of deaths due to pneumococcal disease, Indonesia has not yet included pneumococcal vaccination into the routine program. This study aimed to analyse the cost-effectiveness and the budget impact of pneumococcal vaccination in Indonesia by developing an age-structured cohort model. In a comparison with no vaccination, the use of two vaccines (PCV10 and PCV13) within two pricing scenarios (UNICEF and government contract price) was taken into account. To estimate the cost-effectiveness value, a 5-year time horizon was applied by extrapolating the outcome of the individual in the modelled cohort until 5 years of age with a 1-month analytical cycle. To estimate the affordability value, a 6-year period (2019-2024) was applied by considering the government's strategic plan on pneumococcal vaccination. In a comparison with no vaccination, the results showed that vaccination would reduce pneumococcal disease by 1,702,548 and 2,268,411 cases when using PCV10 and PCV13, respectively. Vaccination could potentially reduce the highest treatment cost from the payer perspective at $53.6 million and $71.4 million for PCV10 and PCV13, respectively. Applying the UNICEF price, the incremental cost-effectiveness ratio (ICER) from the healthcare perspective would be $218 and $162 per QALY-gained for PCV10 and PCV13, respectively. Applying the government contract price, the ICER would be $987 and $747 per QALY-gained for PCV10 and PCV13, respectively. The result confirmed that PCV13 was more cost-effective than PCV10 with both prices. In particular, introduction cost per child was estimated to be $0.91 and vaccination cost of PCV13 per child (3 doses) was estimated to be $16.61 and $59.54 with UNICEF and government contract prices, respectively. Implementation of nationwide vaccination would require approximately $73.3-$75.0 million (13-14% of routine immunization budget) and $257.4-$263.5 million (45-50% of routine immunization budget) with UNICEF and government contract prices, respectively. Sensitivity analysis showed that vaccine efficacy, mortality rate, and vaccine price were the most influential parameters affecting the ICER. In conclusion, pneumococcal vaccination would be a highly cost-effective intervention to be implemented in Indonesia. Yet, applying PCV13 with UNICEF price would give the best cost-effectiveness and affordability values on the routine immunization budget. © 2021 Auliya A. Suwantika et al. |
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pcv 10; Pneumococcus vaccine; Pneumococcus vaccine; Article; budget; budget impact analysis; case control study; case fatality rate; child; cohort analysis; comparative effectiveness; contract; controlled study; cost effectiveness analysis; drug cost; drug efficacy; economic evaluation; government; health care cost; human; incidence; incremental cost effectiveness ratio; Indonesia; infection prevention; mortality rate; outcome assessment; pneumococcal infection; price; quality adjusted life year; sensitivity analysis; strategic planning; Streptococcus pneumonia; United Nations Children's Fund; vaccination; cost benefit analysis; economics; Budgets; Child; Cost-Benefit Analysis; Humans; Indonesia; Pneumococcal Vaccines; Vaccination |
Hindawi Limited |
16879805 |
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33995536 |
Article |
Q2 |
869 |
5372 |
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819 |
Putri A.S., Soedarsono N., Nehemia B., Atmadja D.S., Ubelaker D.H. |
57223021361;14049161500;57204102056;6507824506;7003416830; |
Age estimation of individuals aged 5–23 years based on dental development of the Indonesian population |
2021 |
Forensic Sciences Research |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104502186&doi=10.1080%2f20961790.2021.1886648&partnerID=40&md5=b3c0a614893fe57774dae608436d737a |
Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Putri, A.S., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Nehemia, B., Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Atmadja, D.S., Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ubelaker, D.H., Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Dental development can be used to estimate age for forensic purposes. However, most of the currently available methods are less reliable for the Indonesian population due to population variability. This study presents a new method and evaluates other methods that utilize dental development to estimate the age of Indonesian people. Panoramic radiographs of 304 young Indonesian people aged 5–23 years old were analysed for deciduous tooth root resorption, permanent tooth calcification, and eruption. The extent of tooth root resorption was determined based on AlQahtani’s modified Moorrees et al. method. Tooth calcification was classified based on a modified Demirjian et al. method. Tooth eruption was evaluated based on AlQahtani’s modified Bengston system. The sequence of tooth root resorption, and permanent tooth calcification and eruption were grouped into 19 age categories (from 5–23 years old) in an atlas. The differences between males and females, between maxillary and mandibular teeth, and between right and left teeth were also analysed. There were minimal significant differences of tooth development between males and females, and between the right and left teeth (P > 0.05), while the maxillary and mandibular dental development was significantly different (P < 0.05). The newly developed atlas showed the development of the right side of maxillary and mandibular tooth of combined sex of Indonesian population. Another 34 panoramic radiographs of known-age and sex individuals from Indonesia were assessed using the newly developed Atlas of Dental Development in the Indonesian Population, Ubelaker’s Dental Development Chart, The London Atlas of Human Tooth Development and Eruption by AlQahtani, and the Age Estimation Guide-Modern Australia population by Blenkin-Taylor. Accuracy was assessed by comparing estimated age to actual chronological age using the Bland-Altmand test. Results show that the smallest range of error was found in the Atlas of Dental Development in the Indonesian Population (−0.969 to 1.210 years), followed by The London Atlas of Human Tooth Development and Eruption by AlQahtani (−2.013 to 1.990 years), the Age Estimation Guide-Modern Australia population by Blenkin-Taylor (−2.495 to 2.598 years), the Dental Development Chart by Ubelaker (−2.960 to 3.289 years). These findings show that the Atlas of Dental Development constructed in this study performs better than the other three methods and presents greater accuracy of age estimation in the Indonesian population. Key points •Dental development such as deciduous tooth root resorption, permanent tooth calcification, and tooth eruption can be used to estimate age for forensic purposes. •The development of the teeth are influenced by genetic, ethnicity, and sex, therefore an age estimation method must be constructed based on the same population. •There were minimal significant differences in tooth development between male and female, and between right and left teeth, but there was significant difference between maxillary and mandibular teeth. •The Atlas of Dental Development in the Indonesian Population constructed in this study allowed more accurate age estimation of the Indonesian sample than the other methods tested. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1886648. © 2021 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science. |
age estimation; forensic odontology; Forensic sciences; root resorption; tooth calcification; tooth eruption |
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Taylor and Francis Ltd. |
20961790 |
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Article |
Q1 |
729 |
6779 |
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820 |
Rini I.S., Gunardi A.J., Yashinta, Kevin J., Marsaulina R.P., Aryandono T., Dachlan I., Dwiprahasto I. |
57189690245;57215216664;57223006688;57223012633;57220026579;23495038400;57210391374;6506398126; |
Quality of Life in Palliative Post-mastectomy Reconstruction: Keystone versus Rotational Flap |
2021 |
Plastic and Reconstructive Surgery - Global Open |
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e3457 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104488039&doi=10.1097%2fGOX.0000000000003457&partnerID=40&md5=4e95d37965469db84b820afb28853499 |
Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Rini, I.S., Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Gunardi, A.J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Yashinta, Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Kevin, J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Marsaulina, R.P., Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Aryandono, T., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dachlan, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dwiprahasto, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Background: Late stage breast cancer presents with malignant wound causing skin infiltration, pain, bleeding, and malodour, which affect quality of life (QoL). Palliative mastectomy aims to eliminate wound symptoms and requires prolonged wound care to improve QoL. This study aimed to prospectively investigate QoL differences in 2 alternative reconstructive methods: keystone flap and rotational flap. Methods: Twenty-four late stage breast cancer patients with symptoms of cancer wounds were included in this study. They were divided into 2 groups: keystone flap and rotational flap. Each patient's QoL was evaluated using EORTC QLQ-C30 and QLQ-BR23 before and 3 weeks after surgery. Results: Global health post-surgery was significantly improved compared with pre-surgery in all patients (P < 0.001), across both the keystone (P = 0.018) and rotational groups (P = 0.007). Breast symptoms post-surgery were also improved compared with pre-surgery in all patients (P = 0.035). However, when analyzed per group, breast symptoms were only improved significantly in the keystone group (P = 0.013) but not in the rotational group (P = 0.575). When compared between 2 groups, future perspective post-surgery in the keystone group [100 (0-100)] was better than the rotational group [66.7 (0-100)], (P = 0.020). Conclusions: Reconstructive surgery after mastectomy improves QoL in late stage breast cancer patients. The keystone flap is superior to the rotational flap in improving global health and breast symptoms. © 2021 Georg Thieme Verlag. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
759 |
6437 |
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826 |
Irawati Y., Soedarman S., Arianti A., Widyasari A., Reksodiputro M.H. |
57201260313;57222867991;57201999421;57280734100;35090488800; |
Multiple approaches for managing complex ophthalmic blunt trauma: A case report |
2021 |
International Medical Case Reports Journal |
14 |
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205 |
210 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104124100&doi=10.2147%2fIMCRJ.S304193&partnerID=40&md5=1d5a9d9b836b19267fc2e128d84efc72 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soedarman, S., Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Arianti, A., Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Widyasari, A., JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Reksodiputro, M.H., Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Purpose: This report presents a one-step surgery management process for an intricate case of blunt facial trauma with complex ophthalmic and nasal injury. Patients and Methods: A 45-year-old male with blunt force trauma of the left eye from a wooden block, suffered from naso-orbital-ethmoidal fractures, eyelid laceration with canalicular, close-globe injuries of traumatic cataract and vitreous hemorrhage with retinal detachment. A simultaneous one-step surgery was performed by a trauma team of ophthalmological and ENT surgeons during the height of the COVID-19 pandemic to lessen the risk of cross-transmission. After ruling out the possibility of open-globe rupture, traumatic cataract extraction, retinal detachment surgery, the repair of an eyelid laceration with canalicular involvement, and septorhinoplasty were performed on concomitantly. Results: Anatomical success was achieved for the repair of the nasoorbitoethmoidal (NOE) type II fracture and close-globe injuries, including the anatomical reattachment of the retina. However, the functional outcome remained unsatisfactory. Visual acuity failed to show further improvement at a later follow-up. Traumatic optic neuropathy was, at the final follow-up, considered to be the cause of the suboptimal visual acuity. Conclusion: A single-step multi-procedure for a complex ophthalmic blunt trauma, as demonstrated in this case, may be beneficial for reducing the complications that might arise due to treatment delay. The complex nature of the injury, however, creates the higher possibility for residual post-operative complications. Risks of residual functional impairment should be considered in such complex trauma prior to surgery, to determine the surgical prognostic value and provide appropriate consent to the patient. © 2021 Irawati et al. |
Blunt trauma; Canalicular laceration; Closed-globe injury; Facial injury; Nasal fracture; Ocular trauma |
adult; Article; blunt trauma; case report; cataract; clinical article; clinical examination; conjunctival hemorrhage; crackle; epistaxis; ethmoid bone; eye injury; eyelid closure; eyelid disease; eyelid reconstruction; face fracture; human; hyphema; Indonesia; laceration; lens implantation; male; middle aged; nasopharyngeal swab; nose injury; nose septum reconstruction; occupational accident; orbit fracture; postoperative care; retina detachment; ultrasound; visual acuity; vitrectomy; vitreous hemorrhage |
Dove Medical Press Ltd |
1179142X |
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Article |
Q4 |
198 |
19482 |
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827 |
Haryanto T., Suhartanto H., Arymurthy A.M., Kusmardi K. |
57193869197;16423632300;36815724000;56966625300; |
Conditional sliding windows: An approach for handling data limitation in colorectal histopathology image classification |
2021 |
Informatics in Medicine Unlocked |
23 |
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100565 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104075953&doi=10.1016%2fj.imu.2021.100565&partnerID=40&md5=dceb8084f0a81f31189f09578a878d62 |
Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Haryanto, T., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia, Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Suhartanto, H., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Arymurthy, A.M., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Kusmardi, K., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Large amounts of data are required for the training process with a convolutional neural network (CNN) because small datasets with low variation will cause over-fitting, and the model cannot predict new data with high accuracy. Additionally, the non-availability of histopathological medical data presents an issue because without ethical permission, such data cannot be obtained easily. Therefore, this study proposes a conditional sliding window algorithm to obtain sub-sample data on images of histopathology. Two sets of original data were used, one from the Warwick dataset with dimensions of 775 × 522 pixels and the other from the Department of Pathology and Anatomy, Faculty of Medicine Universitas Indonesia. The algorithm used was inspired by the conventional sliding window method, but implemented with added conditions, such as sliding the window algorithm from the left on (x,y) pixel coordinates, thereby moving from left to right, then up to down until the entire image was covered. Consequently, the new image was produced with two dimensions: 200 × 200 and 300 × 300 pixels. However, to avoid loss of information, the 25 and 50 pixels overlap were used. In this study, CNN 7-5-7 was designed and proposed to perform the process. The conditional sliding window algorithm can produce various sub-samples depending on the image and window size. Furthermore, the images produced were used to develop a CNN and were proven to accurately predict benign and malignant tissues compared to the model from the original dataset. Moreover, the sensitivity values of the Warwick public dataset and the one generated in this study are above 0.80, which shows that the proposed CNN architecture is more stable compared to the existing methods such as AlexNet and DenseNet121. This study succeeded in solving the limitations of colorectal histopathological training data by developing a conditional sliding window algorithm. This algorithm can be applied to generate other histopathological data. Moreover, our proposed CNN 7-5-7 is the fastest architecture for training, comparable to state-of-the-art methodologies. Furthermore, the dataset was used to develop the model for colorectal cancer identification and integrated on the web-based application for further implementation. © 2021 The Authors |
Augmentation; Conditional sliding windows; Convolutional neural network; Histopathology |
Article; colorectal cancer; computer language; convolutional neural network; deep learning; diagnostic accuracy; entropy; feature extraction; histopathology; human; image processing; information processing; learning algorithm; sensitivity and specificity |
Elsevier Ltd |
23529148 |
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Article |
Q3 |
440 |
11223 |
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840 |
Sihombing A.T., Taher A., Rodjani A., Mochtar C.A., Hakim L., Daryanto B., Danarto H.R., Umbas R. |
57218510635;7005269743;6504653529;6506558321;57200406177;57208512904;57222667970;6602634832; |
Assessing the online objective structured clinical examinations in urology qualifying exam for urology residents in Indonesia during COVID-19 time |
2021 |
MethodsX |
8 |
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101316 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103707591&doi=10.1016%2fj.mex.2021.101316&partnerID=40&md5=493809572dae72b1fbf5b2b8e4d8bf25 |
Department of Urology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Urology, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Department of Urology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Sihombing, A.T., Department of Urology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hakim, L., Department of Urology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Daryanto, B., Department of Urology, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Danarto, H.R., Department of Urology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Umbas, R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
This project aimed to assess the Online National Board of Urology Objective Structured Clinical Examination (OSCE) feasibility in evaluating candidates simultaneously from five urology training centers in Indonesia during the COVID-19 pandemic. Data were collected from two online OSCE simulation trials and the Online National Board of Urology OSCE. A self-administered questionnaire was used to assess examiners and candidates’ perception. The average final score of the Online OSCE was compared to previous face-to-face OSCE results. All candidates and examiners (100%) heard and saw clearly the audio-visual in both OSCE simulation trials. None of the candidates had a failing score on the mock exam from all stations. There was a statistically significant difference between the online OSCE and December 2019 face-to-face OSCE. The Online National Board Urology OSCE was feasible and comparable to face-to-face OSCE in evaluating urology candidates. It may be beneficial for the future OSCE method in the medical education system. • Objective Structured Clinical Examination (OSCE) which assesses a broad range of urology candidates’ high-level clinical skills, is a more valid and reliable assessment instrument than the traditional oral examination • The Online National Board of Urology OSCE method can help evaluate urology candidates, especially during the unprecedented COVID-19 pandemic © 2021 |
COVID-19 Pandemic; Online Examination; Online National Board Examination; Online National Board of Urology Objective Structured Clinical Examination (OSCE); OSCE method; Urology Examination |
academic failure; Article; audiovisual aid; clinical examination; coronavirus disease 2019; e-learning; feasibility study; human; Indonesia; medical education; objective structured clinical examination; pandemic; priority journal; resident; simulation; urology |
Elsevier B.V. |
22150161 |
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Article |
Q2 |
356 |
13209 |
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842 |
Rahyussalim A.J., Marsetio A.F., Kamal A.F., Supriadi S., Setyadi I., Pribadi P.M., Mubarok W., Kurniawati T. |
55212166100;57192180884;56648996700;16040272500;57216397660;57194227346;57208440063;55213290600; |
Synthesis, Structural Characterization, Degradation Rate, and Biocompatibility of Magnesium-Carbonate Apatite (Mg-Co3Ap) Composite and Its Potential as Biodegradable Orthopaedic Implant Base Material |
2021 |
Journal of Nanomaterials |
2021 |
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6615614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103563575&doi=10.1155%2f2021%2f6615614&partnerID=40&md5=071473665891e53e20135fe57fd742de |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Marsetio, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Kamal, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Setyadi, I., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Pribadi, P.M., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Mubarok, W., Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Kurniawati, T., Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Suitable biomechanical properties with a degradation rate parallel to normal bone healing time are vital characteristics for biodegradable implant material in orthopaedics. Magnesium (Mg) is a natural micronutrient as well as biodegradable metal with biomechanical characteristics close to that of the human bone, while carbonate apatite (CO3Ap) is a biological apatite with good osteoconductivity which allows bone healing without forming fibrotic tissue. We fabricated a Mg-CO3Ap composite with various content ratios by powder metallurgy, various milling times (3, 5, and 7 hours) at 200 RPM, warm compaction at 300°C and pressure of 265 MPa, sintering at 550°C, holding time of 1 hour, heating rate of 5°C/minutes, and room atmosphere cooling. Specimens were successfully created and had a density comparable to that of the human bone (1.95-2.13 g/cm3). Good biocompatibility was found on Mg-10% CO3Ap composite (66.67% of viable cells). Nevertheless, its biomechanical properties and corrosion resistance were inferior to the human bone. Additionally, the materials of the composites make the surrounding environment alkaline. Interparticle consolidation and grain size were dissatisfactory due to microstructural pores presumably formed by the Mg(OH)2 layer and oxidation process during sintering. However, alkaline condition caused by the material corrosion by-product might be beneficial for bone healing and wound healing process. Modifications on fabrication parameters are needed to improve interparticle consolidation, refine grain size, improve biomechanical strength, reduce corrosion products, and improve the degradation rate. © 2021 Ahmad Jabir Rahyussalim et al. |
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Apatite; Biocompatibility; Biomechanics; Composite structures; Corrosion resistance; Degradation; Grain size and shape; Orthopedics; Powder metallurgy; Sintering; Tissue regeneration; Biodegradable implants; Biomechanical characteristics; Biomechanical properties; Fabrication parameters; Magnesium carbonate apatites; Structural characterization; Surrounding environment; Wound healing process; Magnesium metallurgy |
Hindawi Limited |
16874110 |
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Article |
Q2 |
463 |
10759 |
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844 |
Prihadi J.C., Putra A.C., Wahyudi Y. |
57204771911;36999310900;57215779247; |
Biopsy-confirmed genitourinary tuberculosis in a secondary health care hospital: An evidence-based clinical review |
2021 |
Research and Reports in Urology |
13 |
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133 |
137 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103294921&doi=10.2147%2fRRU.S286899&partnerID=40&md5=762300ffc5d15b605c193bb496ee96d9 |
Department of Surgery, Urology Division, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jakarta, Indonesia; Department of Urology, St. Carolus Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, St. Carolus Hospital, Jakarta, Indonesia |
Prihadi, J.C., Department of Surgery, Urology Division, School of Medicine and Health Sciences, Atma Jaya Catholic University, Jakarta, Indonesia, Department of Urology, St. Carolus Hospital, Jakarta, Indonesia; Putra, A.C., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pulmonology and Respiratory Medicine, St. Carolus Hospital, Jakarta, Indonesia; Wahyudi, Y., Department of Urology, St. Carolus Hospital, Jakarta, Indonesia |
Introduction: Tuberculosis (TB) is a worldwide disease and remains a major public health problem in developing countries, with 95% of cases occurring in developing countries, including Indonesia. It is caused by Mycobacterium tuberculosis, an acid-fast aerobic bacillus. When M. tuberculosis infects other than lung, it is called extrapulmonary tuberculosis (EPTB). Among other organs, genitourinary tuberculosis (GUTB) is responsible for 30– 40% of all EPTB cases. Methods: The study was conducted in a secondary health-care hospital in central Jakarta over a five-year period. We took data from hospital’s medical records and collected all the positive histopathological reports on biopsied tissue of the genitourinary tract from 2014– 2019. Results: Eleven patients showed positive histopathological results for TB on their biopsied genitourinary tissue. The genitourinary tracts involved were as follows: Prostate (n=2), kidney (n=1), ureter (n=2), epididymis (n=1), epididymo-orchitis (n=1), bladder (n=4). All of them presented with specific genitourinary symptoms, such as lower urinary tract symptoms (LUTS) (n=8), dysuria (n=9), urinary retention (n=2), flank pain (n=6), and incontinence (n=1). Nine of 11 patients (81.8%) exhibited systemic manifestations, with fever being the most common (n=8), followed by malaise (n=6), dyspepsia syndrome (n= 4), and weight loss (n=3). Discussion: Consistent with other studies, our research found that the prevalence of GUTB is substantially decreased with advancing age. Kidney is the most common site infected in GUTB infection. GUTB is easily overlooked, because its signs and symptoms are usually typical of a conventional bacterial cystitis. Conclusion: Because of its insidious nature and late-onset symptoms, diagnosis of GUTB is often late to approach, leading to higher morbidity and even mortality rate. This leads into further complications of the disease, which are largely preventable by a correct and timely diagnosis followed by appropriate therapy. © 2021 Prihadi et al. |
Extrapulmonary; Genitourinary; Tuberculosis |
albumin; esterase; abscess; adult; anemia; Article; bladder; body weight loss; clinical article; computer assisted tomography; cystitis; dyspepsia; dysuria; echography; electrolyte disturbance; epididymis; extrapulmonary tuberculosis; female; fever; flank pain; hematuria; histopathology; human; human tissue; hydrocele; hydronephrosis; hydroureter; incontinence; kidney; kidney failure; leukocytosis; leukocyturia; lower urinary tract symptom; malaise; male; morbidity; mortality rate; Mycobacterium tuberculosis; nephrolithiasis; orchitis; prevalence; prostate; proteinuria; public health; pyuria; retrospective study; secondary health care; ureter; urinalysis; urine retention; urogenital tuberculosis |
Dove Medical Press Ltd |
22532447 |
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Article |
Q2 |
506 |
9983 |
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845 |
Aggarwal B., Jones P.W., Yunus F., Lan L.T.T., Boonsawat W., Ismaila A., Ascioglu S. |
23007797900;26121204500;57194486277;55570089700;35608231000;15127439100;57222578443; |
Direct healthcare costs associated with management of asthma: comparison of two treatment regimens in Indonesia, Thailand and Vietnam |
2021 |
Journal of Asthma |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103248190&doi=10.1080%2f02770903.2021.1903915&partnerID=40&md5=24168d049c94d08b0ab06a00763e2d22 |
Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom; Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Value Evidence and Outcomes, GSK, Collegeville, PA, United States; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Clinical Sciences R&D, GSK, Singapore, Singapore |
Aggarwal, B., Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Jones, P.W., Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom, Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Lan, L.T.T., Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Boonsawat, W., Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Ismaila, A., Value Evidence and Outcomes, GSK, Collegeville, PA, United States, Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Ascioglu, S., Clinical Sciences R&D, GSK, Singapore, Singapore |
Objective: Daily inhaled corticosteroid (ICS) and long-acting beta-2-agonist (LABA) combinations comprising either regular maintenance therapy with ICS/LABA plus as-needed short-acting beta-2-agonist (SABA) or ICS-formoterol combinations used as maintenance and reliever therapy (MART) are recommended for moderate asthma. This analysis compares the direct costs of twice-daily fluticasone propionate/salmeterol (FP/salm) and budesonide/formoterol MART in three Southeast Asian countries. Methods: A literature review identified three randomized trials in patients with asthma (≥ 12 years) comparing regular twice-daily FP/salm with as-needed SABA versus MART in moderate asthma: AHEAD (NCT00242775/17 countries/2309 patients), COMPASS (AstraZeneca study SD-039-0735/16 countries/3335 patients), and COSMOS (AstraZeneca study SD-039-0691/16 countries/2143 patients). Economic analyses, conducted from a healthcare sector perspective (medication costs + healthcare utilization costs), applied unit costs from countries where healthcare costs are publicly available: Indonesia, Thailand and Vietnam. Results are expressed in British pound sterling (GBP/patient/year). Results: Annual exacerbation rates were low and differences between treatment strategies were small (range, FP/salm: 0.31–0.38, MART: 0.24–0.25) although statistically significant in favor of MART. Total average (minimum-maximum) direct costs (in GBP/patient/year) across the three studies were £187 (£137–£284), £158 (£125–£190), and £151 (£141–£164) for those who used FP/salm, and £242 (£217–£267), £284 (£237–£340) and £266 (£224–£315) for MART in Indonesia, Thailand and Vietnam, respectively. On average, total direct costs/patient/year with FP/salm were 22.8%, 44.6% and 43.0% lower than with MART for Indonesia, Thailand and Vietnam, respectively. Conclusions: In the three countries evaluated, total treatment costs with regular twice-daily FP/salm were consistently lower than with budesonide/formoterol MART due to lower direct healthcare costs. © 2021 GlaxoSmithKline. Published with license by Taylor & Francis Group, LLC. |
healthcare utilization; ICS/LABA; maintenance therapy; medication; Southeast Asia |
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Taylor and Francis Ltd. |
02770903 |
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Article |
Q2 |
687 |
7267 |
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