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847 |
Atmosudigdo I.S., Lim M.A., Radi B., Henrina J., Yonas E., Vania R., Pranata R. |
57222578186;57216039756;6603494019;57218482646;57201987097;57208328436;57201973901; |
Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression |
2021 |
Clinical Medicine Insights: Endocrinology and Diabetes |
14 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103239096&doi=10.1177%2f1179551421990675&partnerID=40&md5=f2529886c6cb74cf353635e1abd100c3 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia |
Atmosudigdo, I.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Radi, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association. Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study’s main outcome is a poor composite outcome, comprising of mortality and severe COVID-19. Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P =.010; I2: 56.7%, P =.018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P =.008; I2: 57.4%, P =.029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: −0.04, P =.033), male gender (coefficient: −0.03, P =.042), and hypertension (coefficient: −0.02, P =.033), but not diabetes (coefficient: −0.24, P =.135) and cardiovascular diseases (coefficient: −0.01, P =.506). Inverted funnel-plot was relatively symmetrical. Egger’s test indicates that the pooled analysis was not statistically significant for small-study effects (P =.206). Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension. PROSPERO Registration Number: CRD42020213491 © The Author(s) 2021. |
coronavirus; COVID-19; dyslipidemia; hyperlipidemia; prognosis |
Article; comorbidity; coronavirus disease 2019; diabetes mellitus; disease association; disease severity; dyslipidemia; human; hypertension; infection risk; mortality; prevalence; prognosis; risk assessment; systematic review |
SAGE Publications Ltd |
11795514 |
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Article |
Q3 |
527 |
9598 |
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848 |
Gunardi E.R., Susilo S.A. |
57192910998;57191052854; |
Menstrual Pattern and Characteristics of One-Rod and Two-Rod Levonorgestrel Implant Users |
2021 |
Obstetrics and Gynecology International |
2021 |
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2904542 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103051337&doi=10.1155%2f2021%2f2904542&partnerID=40&md5=9c88e8c5346ee41a0b8def57849e05c1 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia; Susilo, S.A., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Introduction. The maternal mortality ratio (MMR) in Indonesia reaches 359 per 100,000 live births. The long-acting reversible contraceptive (LARC) method is an effective contraceptive choice for reducing MMR. The contraceptive implant is one of the LARCs that has low usage due to lack of education about the side effects. This study aims to compare the menstrual pattern and characteristics between one-rod and two-rod levonorgestrel implant users. Methods. A prospective cohort study was performed in patients at Cipto Mangunkusumo Hospital (RSCM) from March 2016 to May 2018. Subject recruitment was done by consecutive sampling. This study was conducted from March 2016 until May 2019. Statistical analysis was performed on the data using the chi-square test to determine the relationship between menstrual pattern and characteristics, and the use of one-rod or two-rod levonorgestrel implants. Results. A total of 140 subjects participated in the study, comprising 70 (50%) one-rod users and 70 (50%) two-rod users. In the first month, 32.9% one-rod users experienced amenorrhea, 22.9% experienced shortened menstrual period, 30% experienced normal menstrual period, and 14,2 % experienced lengthened menstrual period. In comparison, in the first month, 41.4% two-rod users experienced amenorrhea, 15.7% experienced shortened menstrual period, 32.9% experienced normal menstrual period, and 10% experienced lengthened menstrual period. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Conclusion. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Implications. Menstrual patterns and characteristics from levonorgestrel implants user can help clinicians to reduce discontinuation rate from the acceptors. Further research should be conducted to know other side effects aside from menstrual bleeding patterns. © 2021 Eka Rusdianto Gunardi and Sulaeman Andrianto Susilo. |
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injectable contraceptive agent; levonorgestrel; oral contraceptive agent; adult; amenorrhea; Article; body mass; breast feeding; cohort analysis; comparative study; controlled study; data analysis software; female; human; long-acting reversible contraception; major clinical study; menstrual cycle; menstruation; obesity; prospective study; underweight |
Hindawi Limited |
16879589 |
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Article |
Q2 |
648 |
7760 |
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852 |
Birowo P., Raharja P.A.R., Atmoko W., Rasyid N. |
6504153311;57201013616;57193125664;56245069300; |
X-ray-free endoscopic combined intrarenal surgery for complex proximal ureteral stone: A case report |
2021 |
Research and Reports in Urology |
13 |
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121 |
125 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102769053&doi=10.2147%2fRRU.S299707&partnerID=40&md5=032063a30ddb79b23195d2c16a6aaa56 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia |
X-ray-free endoscopic combined intra renal surgery (ECIRS) is a feasible alternative to avoid radiation exposure to both surgical teams and patients, but has not been reported prior. The aim of this report is to present our first-hand experience of performing X-ray-free ECIRS for complex ureteral stone. A 57-year-old female presented with right flank pain, fever, dysuria, and leukocytosis. The computed tomography scan showed right impacted proximal ureteral stone sized 33 ´17 mm and grade IV hydrone-phrosis. Percutaneous nephrostomy was performed immediately. With improvement of clinical symptoms two days after nephrostomy, X-ray-free ECIRS was performed. The patient was placed in a Galdakao-modified supine position. During ureteroscopy (URS), there was noted right ureteral stenosis in the distal part of the stone, which could be passed. However, the stone was impacted and the semi-rigid URS was not able to push it. Therefore, antegrade approach with percutaneous nephrolithotomy was performed. Previous nephrostomy tract was used as percutaneous access. Tract dilatation was performed under direct visualization from the URS. The 28 Fr rigid nephroscope was used during the ECIRS procedure. The stone was fragmented using shock-pulse litho-tripters. There was no residual stone or infundibular laceration after the procedure. A 6 Fr double J stent was inserted retrogradely due to ureteral stenosis. There was no complication during and after the procedure. The patient was discharged on post-operative day three. X-ray free ECIRS for complex proximal ureteral stone was possible and showed good results. © 2021 Birowo et al. |
ECIRS; Modified procedure; Supine position; Ureterolithiasis |
creatinine; esterase; hemoglobin; levofloxacin; adult; Article; case report; clinical article; computer assisted tomography; creatinine blood level; diagnostic test accuracy study; dysuria; endoscopic surgery; Escherichia coli; female; fever; flank pain; hemoglobin blood level; human; human tissue; hydronephrosis; hydroureter; injection site reaction; kidney calyx; kidney surgery; leukocytosis; middle aged; nausea and vomiting; neutrophil; operation duration; operative blood loss; percussion; percutaneous nephrolithotomy; percutaneous nephrostomy; radiation exposure; supine position; ureter obstruction; ureter stone; ureteroscopy; urinalysis; X ray; x-ray computed tomography |
Dove Medical Press Ltd |
22532447 |
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Article |
Q2 |
506 |
9983 |
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855 |
Syahrul S., Maliga H.A., Ilmawan M., Fahriani M., Mamada S.S., Fajar J.K., Frediansyah A., Syahrul F.N., Imran I., Haris S., Rambe A.S., Emran T.B., Rabaan A.A., Tiwari R., Dhama K., Nainu F., Mutiawati E., Harapan H. |
57216064819;57222334227;57217182580;57219947648;57211891425;56156139600;56897210000;57222337525;56589826700;57222343545;57193757980;55325267100;56049830800;55314856100;6507396956;57120069200;56652288600;55844857500; |
Hemorrhagic and ischemic stroke in patients with coronavirus disease 2019: Incidence, risk factors, and pathogenesis - a systematic review and meta-analysis |
2021 |
F1000Research |
10 |
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34 |
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12 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102340647&doi=10.12688%2ff1000research.42308.1&partnerID=40&md5=8cfb8151ce9b8e51bb3ec5847e7a2ca5 |
Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, 20155, Indonesia; Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh; Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia; Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh, 281 001, India; Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Syahrul, S., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Maliga, H.A., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Ilmawan, M., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia; Fahriani, M., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Mamada, S.S., Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Fajar, J.K., Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65117, Indonesia, Brawijaya Internal Medicine Research Center, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, East Java, 65145, Indonesia; Frediansyah, A., Research Division for Natural Product Technology (BPTBA), Indonesian Institute of Sciences (LIPI), Wonosari, 55861, Indonesia; Syahrul, F.N., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia; Imran, I., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Haris, S., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Rambe, A.S., Department of Neurology, Faculty of Medicine, Universitas Sumatera Utara, Medan, North Sumatra, 20155, Indonesia; Emran, T.B., Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, 4381, Bangladesh; Rabaan, A.A., Molecular Diagnostic Laboratory, Johns Hopkins Aramco Healthcare, Dhahran, 31311, Saudi Arabia; Tiwari, R., Department of Veterinary Microbiology and Immunology, College of Veterinary Sciences, UP Pandit Deen Upadhayay Pashu Chikitsa Vigyan Vishwavidyalay Evum Go-Anusandhan Sansthan (DUVASU), Mathura, Uttar Pradesh, 281 001, India; Dhama, K., Division of Pathology, ICAR-Indian Veterinary Research Institute, Izatnagar, Uttar Pradesh, 243122, India; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Makassar, South Sulawesi, 90245, Indonesia; Mutiawati, E., Department of Neurology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Neurology, Dr. Zainoel Abidin Hospital, Banda Aceh, Aceh, 23111, Indonesia; Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Aceh, 23111, Indonesia |
Background: In this study, we aimed to determine the global prevalence, chronological order of symptom appearance, and mortality rates with regard to hemorrhagic and ischemic stroke in patients with coronavirus disease 2019 (COVID-19) and to discuss possible pathogeneses of hemorrhagic and ischemic stroke in individuals with the disease. Methods: We searched the PubMed, Scopus, and Web of Science databases for relevant articles published up to November 8, 2020. Data regarding study characteristics, hemorrhagic stroke, ischemic stroke, and COVID-19 were retrieved in accordance with the PRISMA guidelines. The Newcastle-Ottawa scale was used to assess the quality of the eligible studies. The pooled prevalence and mortality rate of hemorrhagic and ischemic stroke were calculated. Results: The pooled estimate of prevalence of hemorrhagic stroke was 0.46% (95% CI 0.40%-0.53%; I 2 =89.81%) among 67,155 COVID-19 patients and that of ischemic stroke was 1.11% (95% CI 1.03%-1.22%; I 2 =94.07%) among 58,104 COVID-19 patients. Ischemic stroke was more predominant (incidence: 71.58%) than hemorrhagic stroke (incidence: 28.42%) in COVID-19 patients who experienced a stroke. In COVID-19 patients who experienced a stroke, hospital admission with respiratory symptoms was more commonly reported than that with neurological symptoms (20.83% for hemorrhagic stroke and 5.51% for ischemic stroke versus 6.94% for hemorrhagic stroke and 5.33% for ischemic stroke, respectively). The pooled mortality rate of COVID-19 patients who experienced a hemorrhagic and ischemic stroke was 44.72% (95% CI 36.73%-52.98%) and 36.23% (95% CI 30.63%-42.24%), respectively. Conclusions: Although the occurrence of hemorrhagic and ischemic stroke is low, the mortality rates of both stroke types in patients with COVID-19 are concerning, and therefore, despite several potential pathogeneses that have been proposed, studies aimed at definitively elucidating the mechanisms of hemorrhagic and ischemic stroke in individuals with COVID-19 are warranted. PROSPERO registration: CRD42020224470 (04/12/20) © 2021 Syahrul S et al. |
COVID-19; Haemorrhagic stroke; Ischemic stroke; Meta-analysis; Pathogenesis; SARS-CoV-2; Systematic review |
Article; brain hemorrhage; clinical feature; clinical outcome; coronavirus disease 2019; hospital admission; human; incidence; ischemic stroke; meta analysis (topic); mortality rate; neurologic disease; Newcastle-Ottawa scale; pathogenesis; pooled analysis; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; publication bias; respiratory tract disease; risk factor; statistical analysis; symptom; systematic review; brain ischemia; complication; incidence; meta analysis; prospective study; retrospective study; risk factor; Brain Ischemia; COVID-19; Humans; Incidence; Ischemic Stroke; Prospective Studies; Retrospective Studies; Risk Factors |
F1000 Research Ltd |
20461402 |
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33708378 |
Article |
Q1 |
1099 |
3793 |
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856 |
Rinaldi I., Louisa M., Sari R.M., Arwanih E. |
23475122400;41461551400;57208474079;57222314110; |
Flt3-itd mutation and flt3 ligand plasma level were not associated with one-year survival of Indonesian acute myeloid leukemia patients |
2021 |
OncoTargets and Therapy |
14 |
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1479 |
1486 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102287355&doi=10.2147%2fOTT.S282842&partnerID=40&md5=67e8a263fb7385921e3a50606454ebd6 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, R.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arwanih, E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To analyze the association of FLT3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian acute myeloid leukemia (AML) patients. Methods: A prospective cohort study was conducted to determine the association between FLT-3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian AML patients. In the study, a total of 51 AML patients were obtained from two tertiary hospitals in Indonesia from year 2018 to 2020. Inclusion criteria were de novo AML male and female patients aged ≥18 years old. Exclusion criteria were prior myelodysplastic syndrome and patients that refused to participate in the study. FLT3-ITD genotype of patients was then analyzed using PCR method while FLT3 ligand plasma level was measured using ELISA method. Patients were then followed-up for 1 year or until death occurred with survival as the measured outcome. Association between independent and dependent variable were analyzed by cox regression proportional hazard. Results: Eleven patients (21.5%) in this study had FLT3-ITD mutation. The median age of AML patients was 45 (18–71) years, and the median blast percentage was 50% (5–87%). After one-year follow-up, 33 (64.7%) patients had died. The median survival of AML patients was 6 months. Univariate analysis showed no association between FLT3-ITD mutation status (HR: 1.051; 95% CI: 0.483–2.286; P: 0.901) and FLT3 ligand plasma level (HR: 0.798; 95% CI: 0.347–1.837; p= 0.596), and age (HR: 1.283; 95% CI: 0.575–2.862; p= 0.542) with one-year survival of AML patients, but multivariate analysis showed association between GFR with one-year survival of AML patients in this cohort (HR: 4.053; 95% CI: 1.469–11.183; p= 0.007). Conclusion: One-year survival of AML patients in Indonesia is not affected by FLT3-ITD mutation and FLT3 ligand plasma level. However, GFR showed association with one-year survival of AML patient in this cohort study. © 2021 Rinaldi et al. |
Acute myeloid leukemia; FLT3 Ligand Plasma; FLT3-ITD; One-year survival |
Flt3 ligand; acute myeloid leukemia; adult; age; aged; Article; cancer survival; clinical feature; cohort analysis; comparative study; controlled study; enzyme linked immunosorbent assay; female; follow up; gene mutation; genetic association; genotype; human; Indonesian; kidney function; major clinical study; male; myelodysplastic syndrome; outcome assessment; overall survival; polymerase chain reaction; prevalence; prospective study; protein blood level; survival time |
Dove Medical Press Ltd |
11786930 |
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Article |
Q2 |
1054 |
4053 |
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857 |
Sahar N., Muharam R., Pradhita A.D., Thuffi R., Zulhulaifah W.O., Birowo P. |
57212464367;57191492732;57212471291;57212475033;57222324817;6504153311; |
Expression of E-Cadherin in Pig-Tailed Monkey (Macaca nemestrina) Endometrium after Controlled Ovarian Hyperstimulation |
2021 |
BioMed Research International |
2021 |
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8824614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102282318&doi=10.1155%2f2021%2f8824614&partnerID=40&md5=174042679bf5a7630610257f7a24b9a7 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Pradhita, A.D., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zulhulaifah, W.O., Master Program Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
An increase of steroid hormones in controlled ovarian hyperstimulation (COH) procedures is reducing the success rate in assisted reproductive technology (ART), and this includes the pregnancy rate and/or implantation rate. Research has found that the decrease in the success rate occurred due to the decreased expression of the protein that is needed to prepare the endometrium so that the embryo could attach. The aim of the study was to analyse the changes in E-chaderin expression due to COH and its relations with increased level of steroid hormones as one of the proteins in the endometrium. There were 13 samples of stored biological tissue from Macaca nemestrina endometrial tissue; came from one group of natural cycles as the control group (n=4) and three groups of stimulated cycles. The first stimulated cycle group was injected by a 30 IU dose of rFSH (n=2). The second stimulated cycle group was injected by a 50 IU dose of rFSH (n=4). The third stimulated cycle group was injected by a 70 IU dose of rFSH (n=3). The expression of E-cadherin was measured by the immunohistochemistry (IHC) technique. Estradiol (E2) and progesterone (P4) levels were assessed using ELISA and have already been done. The IHC staining expression of E-cadherin was found in the cytoplasm of glandular epithelium. Immunostaining measurement used the H_SCORE. We found that the expression of E-cadherin within the group was not significantly different (p value: 0.178). Similarly, both the correlation between the estradiol level with E-cadherin and the correlation between the progesterone level with E-cadherin were not significantly different (p value: 0.872 and p value: 0.836). The conclusion is that the level of E-Cadherin expression in the endometrium that were taken in themiddle secretion phase not affected by the dose regimen that given. In addition, the level of expression is not influenced by the increase of serum E2 and P4 levels. © 2021 Nurhuda Sahar et al. |
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buserelin; chorionic gonadotropin; estradiol; progesterone; recombinant follitropin; uvomorulin; cadherin; animal experiment; animal tissue; Article; comparative study; controlled study; cytoplasm; endometrium; enzyme linked immunosorbent assay; estradiol blood level; female; follicular phase; immunohistochemistry; Macaca nemestrina; mitosis; nonhuman; ovary hyperstimulation; progesterone blood level; protein expression; retrospective study; animal; biosynthesis; endometrium; metabolism; ovulation induction; Animals; Cadherins; Endometrium; Female; Macaca nemestrina; Ovulation Induction |
Hindawi Limited |
23146133 |
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33708995 |
Article |
Q2 |
772 |
6290 |
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859 |
Gunardi W.D., Karuniawati A., Umbas R., Bardosono S., Lydia A., Soebandrio A., Safari D. |
57222314683;54886816200;6602634832;21933841000;8451287200;8602893200;23493586700; |
Biofilm-Producing Bacteria and Risk Factors (Gender and Duration of Catheterization) Characterized as Catheter-Associated Biofilm Formation |
2021 |
International Journal of Microbiology |
2021 |
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8869275 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102259916&doi=10.1155%2f2021%2f8869275&partnerID=40&md5=2173f2f0a162e1277f45979d11bf433c |
Department of Clinical Microbiology, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 1151, Indonesia; Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Urology, FMUI-CMH, Jakarta, 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia |
Gunardi, W.D., Department of Clinical Microbiology, Faculty of Medicine, Krida Wacana Christian University, Jakarta, 1151, Indonesia; Karuniawati, A., Department of Clinical Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Umbas, R., Department of Urology, FMUI-CMH, Jakarta, 10430, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Lydia, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia; Safari, D., Eijkman Institute for Molecular Biology, Jakarta, 10430, Indonesia |
Background. A catheter-associated urinary tract infection (CA-UTI) is preceded by biofilm formation, which is related to several risk factors such as gender, age, diabetic status, duration of catheterization, bacteriuria before catheterization, virulence gene factor, and antibiotic usage. Aims. This study aims to identify the microbial composition of catheter samples, including its corresponding comparison with urine samples, to determine the most important risk factors of biofilm formation and characterize the virulence gene factors that correlate with biofilm formation. Methods. A longitudinal cross-sectional study was conducted on 109 catheterized patients from September 2017 to January 2018. The risk factors were obtained from the patients' medical records. All catheter and urine samples were cultured after removal, followed by biomass quantification. Isolate identification and antimicrobial susceptibility testing were performed using the Vitex2 system. Biofilm-producing bacteria were identified by the Congo Red Agar (CRA) method. A PCR test characterized the virulence genes of dominant bacteria (E. coli). All data were collected and processed for statistical analysis. Results. Out of 109 catheterized patients, 78% of the catheters were culture positive, which was higher than those of the urine samples (37.62%). The most common species isolated from the catheter cultures were Escherichia coli (28.1%), Candida sp. (17.8%), Klebsiella pneumoniae (15.9%), and Enterococcus faecalis (13.1%). E. coli (83.3%) and E. faecalis (78.6%) were the main isolates with a positive CRA. A statistical analysis showed that gender and duration prior to catheterization were associated with an increased risk of biofilm formation p<0.05. Conclusion. E. coli and E. faecalis were the most common biofilm-producing bacteria isolated from the urinary catheter. Gender and duration are two risk factors associated with biofilm formation, therefore determining the risk of CAUTI. The presence of PapC as a virulence gene encoding pili correlates with the biofilm formation. Biofilm-producing bacteria, female gender, duration of catheterization (more than five days), and PapC gene presence have strong correlation with the biofilm formation. To prevent CAUTI, patients with risk factors should be monitored by urinalysis tests to detect earlier the risk of biofilm formation. © 2021 Wani Devita Gunardi et al. |
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Hindawi Limited |
1687918X |
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Article |
Q3 |
696 |
7161 |
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863 |
Sahlan M., Tejamaya M., Arbianti R., Baruji T., Adawiyah R., Hermansyah H. |
57189182661;55295863200;55897945700;57222240819;57208658742;15759436800; |
The effects of nano-casein encapsulation and productions of a controlled-release on eugenol containing bio-pesticide toxicity |
2021 |
Key Engineering Materials |
874 KEM |
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115 |
127 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101971950&doi=10.4028%2fwww.scientific.net%2fKEM.874.115&partnerID=40&md5=6f6b175ce47bb2305dfbaffecf2240a3 |
Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Tejamaya, M., Department of Occupational Health and Safety, Faculty of Public Health, Universitas Indonesia, Depok, 16424, Indonesia; Arbianti, R., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia; Baruji, T., Center of Bioindustry Technology, Agency for The Assessment and Application of Technology, Jakarta, 10340, Indonesia; Adawiyah, R., Research Center of Biomedical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Hermansyah, H., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, 16424, Indonesia |
The concern against long-term health and environmental adverse effects of synthetic pesticides has encouraged the development of bio-pesticides. Eugenol, a major constituent of clove oil, has been proven as potential bio-pesticides. However, evaporation and photosensitive properties of Eugenol needs to be controlled. Nano-encapsulation is a promising method that can preserve eugenol from evaporating and photodegradation. This study aims to investigate the production of a controlled-release of eugenol in casein micelle as well as the effects of nano-encapsulation on Eugenol Containing Biopesticide (ECB) toxicity against Artemia salina sp. Brine Shrimp Lethality Test (BSLT) was implemented to investigate effect of nano-encapsulation on ECB and the Response Surface Methodology was used to optimize the formula to investigate the production of a controlled-release of eugenol. The optimum condition revealed loading capacity and encapsulation efficiency response for 64.67% and 79.64%, respectively. The average diameter of the obtained nanocapsule-eugenol (NCE) was 179.83 nm. Release study was performed at 40 °C that represent as pesticide applied in farm, revealed that casein micelle capsule could delayed the release of eugenol. A cytotoxicity assay showed that the NCE has 21 times more effective compared with eugenol only. It was found that nano encapsulated ECB was statistically more toxic than ECBsuspension (without nano encapsulation) with a confidence level of 95%. Lethal Concentration 50 (LC50) of nano-ECB was 0.264 μg/L while LC50 of ECB-suspension was 4.445 μg/L. The increase of toxic properties after nano-encapsulation by casein could be explained by the increase of eugenol stability. Thus nano-encapsulation can be proposed as a method for improving the bio-pesticide ability of eugenol. © 2021 Trans Tech Publications Ltd, Switzerland. |
Biopesticide; BSLT1; Casein; Controlled-release; Eugenol; Nano encapsulation; Optimizing |
Casein; Dairies; Micelles; Suspensions (fluids); Toxicity; Brine shrimp lethalities; Cytotoxicity assays; Encapsulation efficiency; Investigate effects; Lethal concentration; Photosensitive properties; Response surface methodology; Synthetic pesticides; Pesticide effects |
Trans Tech Publications Ltd |
10139826 |
9783035737639 |
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Conference Paper |
Q4 |
175 |
21056 |
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865 |
Silitonga P., Dewi B.E., Bustamam A., Al-Ash H.S. |
57219406661;24076058600;36815737800;57205062769; |
Evaluation of Dengue Model Performances Developed Using Artificial Neural Network and Random Forest Classifiers |
2021 |
Procedia Computer Science |
179 |
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135 |
143 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101780236&doi=10.1016%2fj.procs.2020.12.018&partnerID=40&md5=bf5f6b6b59db9e4a155ff56ac22ceeaf |
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.5, Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Computer Science, Faculty of Computer Science, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia |
Silitonga, P., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.5, Jakarta Pusat, Jakarta, 10430, Indonesia; Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Al-Ash, H.S., Department of Computer Science, Faculty of Computer Science, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia |
Dengue is one of the endemic diseases in Indonesia. Dengue is being suffered by many people, regardless of their gender and age. Therefore, research about dengue based on dengue patients' data was conducted. There was a lot of information written in that data regarding the corresponding patients and the dengue they had suffered, such as gender, age, how long the patients were hospitalized, the symptoms they experienced, and laboratory characteristics results. Diagnosis of each of the corresponding patients based on their symptoms and laboratory characteristics results were also written in that data. The diagnoses were classified into three different clinical degrees according to the severity level, which is DF as the mild level, DHF grade 1 as the intermediate level, and DHF grade 2 as the severe level. In this research, data of the patients on the third day of being hospitalized was analyzed, because, on the third day, dengue is entering a critical phase. The objectives of this research were: to evaluate the performance of the models that were used to predict the correct class within the given dataset developed using Artificial Neural Network (ANN) classifier and Random Forest (RF) classifier separately, and to find a classifier that yielded the best performance. The results obtained from this research will be used in the development of a Machine Learning model that can predict the clinical degree of dengue in the critical phase, if the laboratory characteristics results are known, using a classifier that yielded the best performance. © 2021 Elsevier B.V.. All rights reserved. |
Artificial Neural Network; Dengue; Random Forest |
Classification (of information); Clinical research; Decision trees; Diagnosis; Intelligent computing; Random forests; Turing machines; Indonesia; Intermediate level; Machine learning models; Model performance; Random forest classifier; Neural networks |
Elsevier B.V. |
18770509 |
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Conference Paper |
- |
334 |
13810 |
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870 |
Prasetyo M., Rahardja R.R., Yanuar A., Prihartono J., Setiawan S.I. |
57192905252;57222100194;57222087272;6602605635;57195939543; |
Ultrasonography evaluation of the normal ulnar nerve in adult: Comparison of the cross-sectional area at elbow extension and flexion |
2021 |
European Journal of Radiology Open |
8 |
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100331 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101370509&doi=10.1016%2fj.ejro.2021.100331&partnerID=40&md5=f9e415e711bd67bbe8b7b71cf1b20376 |
Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Rahardja, R.R., Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Yanuar, A., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Prihartono, J., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Cross-sectional area (CSA) measurement of the ulnar nerve in the adult population by using ultrasonography (US) at elbow extension and flexion has previously been reported, but not much evidence showed a significant difference between elbow extension and flexion position. Purpose: To compare the ulnar nerve CSA between elbow extension and flexion position. Methods: A comparative cross-sectional study was conducted by involving 36 healthy adults with normally functioning ulnar nerve proven by Nerve Conduction Study (NCS) or Electroneurography. The ulnar nerve CSA was measured on each elbow by using US at the level of the medial epicondyle, 2 cm distal and 2 cm proximal from the medial epicondyle. Results: The average ulnar nerve CSA at the medial epicondyle, 2 cm distal and proximal to the medial epicondyle at elbow extension respectively were 5.95 ± 0.74 mm2, 6.27 ± 0.92 mm2, and 5.92 ± 0.73 mm2. At elbow flexion, the average ulnar nerve CSA at the positions was 5.70 ± 0.83 mm2, 5.23 ± 0.87 mm2, dan 5.73 ± 0.71 mm2 respectively. The CSA of the ulnar nerve at elbow extension was significantly larger compared to the flexion position in the three areas observed in this study (p < 0.001). Conclusion: The CSA of the ulnar nerve at elbow extension position was larger compared to the flexion position. Elbow position should be considered in measuring CSA of the ulnar nerve. © 2021 The Author(s) |
Cross-sectional area; Medial epicondyle; Ulnar nerve; Ultrasonography |
adult; article; clinical article; controlled study; cross-sectional study; echography; elbow flexion; electroneurography; female; human; human experiment; male; nerve conduction; ulnar nerve |
Elsevier Ltd |
23520477 |
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Article |
Q3 |
490 |
10260 |
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