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377 |
Dharma S., Dakota I., Firdaus I., Danny S.S., Zamroni D., Yudha A., Susanto A., Siswanto B.B. |
55101301700;55796663700;55796864700;56221848700;57215684617;57223107725;57225841633;14422648800; |
Performance of Primary Angioplasty for STEMI during the COVID-19 Outbreak |
2021 |
International Journal of Angiology |
30 |
2 |
210001 |
148 |
154 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104870014&doi=10.1055%2fs-0041-1727133&partnerID=40&md5=5b349c0b1a14cb4af4bcc5b822d2e435 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Catheterization Laboratory Nurse Manager, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Dharma, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jl S Parman Kav 87, Slipi, Jakarta Barat, Jakarta, 11420, Indonesia; Dakota, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Firdaus, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Danny, S.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Zamroni, D., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Yudha, A., Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Susanto, A., Catheterization Laboratory Nurse Manager, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
There has been concern whether the declining cases of ST-segment elevation myocardial infarction (STEMI) during the coronavirus disease 2019 (COVID-19) outbreak associate with primary angioplasty performance. We assessed the performance of primary angioplasty in a tertiary care hospital in Jakarta, Indonesia, by comparing the door-to-device (DTD) time and thrombolysis in myocardial infarction (TIMI) flow after angioplasty between two periods of admission: during the outbreak of COVID-19 (March 1 to May 31, 2020) and before the outbreak (March 1, to May 31, 2019). Overall, there was a relative reduction of 44% for STEMI admission during the outbreak (n = 116) compared with before the outbreak (N = 208). Compared with before the outbreak period (n = 141), STEMI patients who admitted during the outbreak and received primary angioplasty (n = 70) had similar median symptom onset-to-angioplasty center admission (360 minutes for each group), similar to radial access uptake (90 vs. 89.4%, p = 0.88) and left anterior descending infarct-related artery (54.3 vs. 58.9%, p = 0.52). The median DTD time and total ischemia time were longer (104 vs. 81 minutes, p < 0.001, and 475.5 vs. 449 minutes, p = 0.43, respectively). However, the final achievement of TIMI 3 flow was similar (87.1 vs. 87.2%), and so was the in-hospital mortality (5.7 vs. 7.8%). During the COVID-19 outbreak, we found a longer DTD time for primary angioplasty, but the achievement of final TIMI 3 flow and in-hospital mortality were similar as compared with before the outbreak. Thus, primary angioplasty should remain the standard of care for STEMI during the COVID-19 outbreak. © 2020. International College of Angiology. All rights reserved. |
COVID-19 outbreak; performance measures; primary angioplasty |
acetylsalicylic acid; angiotensin receptor antagonist; beta adrenergic receptor blocking agent; clopidogrel; creatinine; dipeptidyl carboxypeptidase inhibitor; heparin; salicylic acid; simvastatin; ticagrelor; adult; angioplasty; Article; cardiovascular risk factor; catheterization; controlled study; coronary angiography; coronavirus disease 2019; creatinine blood level; door to device time; emergency ward; epidemic; female; fibrinolytic therapy; health care utilization; heart left bundle branch block; hospital admission; hospital discharge; human; in-hospital mortality; Indonesia; information processing; ischemia time; length of stay; major clinical study; male; non ST segment elevation myocardial infarction; observational study; outcome assessment; percutaneous coronary intervention; pos |
Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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380 |
Kurniawan R., Nur R.J.B., Yuliyanti S., Nuridzin D.Z., Kartinah N.T. |
57189681782;57222637045;57222633264;57222637716;57192914846; |
Healthy family index assessment through community-based health information system approach |
2021 |
International Journal of Public Health Science |
10 |
2 |
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394 |
400 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103597839&doi=10.11591%2fijphs.v10i2.20751&partnerID=40&md5=fe1ac4f92382153c62ee102a2fadb48f |
Department of Biostatistic and Population Study, Faculty of Public Health, Universitas Indonesia, Indonesia; Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Department of Physiology Pre-Clinic, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kurniawan, R., Department of Biostatistic and Population Study, Faculty of Public Health, Universitas Indonesia, Indonesia; Nur, R.J.B., Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Yuliyanti, S., Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Nuridzin, D.Z., Research Center for Biostatistics and Health Informatics, Faculty of Public Health, Universitas Indonesia, Indonesia; Kartinah, N.T., Department of Physiology Pre-Clinic, Faculty of Medicine, Universitas Indonesia, Indonesia |
The healthy Indonesia program with a family approach (PIS-PK) has not been implemented optimally. There are several obstacles and challenges in this program’s implementation, e.g., human resources. A community-based health information system (CBHIS) is a strategic approach to obtain data and information at the population level by directly involving cadres and the community. A project with the CBHIS approach was implemented in Kasemen Village, Serang, Banten Province, Indonesia to support the PIS-PK program. The study aimed to determine the population’s health status according to the healthy family index through the CBHIS approach. The data of healthy family indicators in the village were collected by cadres using a mHealth application. Overall, 1316 households consisting of 5312 residents were registered. The analysis results of the healthy family index showed that most families in the Kasemen subdistrict were pre-healthy (64.2%), almost one third were unhealthy (27.8%) and only a small proportion were healthy (8%). Assessing the healthy family index through the CBHIS approach can support decision-making at the community level, thereby determining the magnitude of family health problems and providing appropriate interventions to improve community health status. Well-trained cadres equipped with better electronic data collection tools may be an alternative to community-based data collection. © 2021, Institute of Advanced Engineering and Science. All rights reserved. |
Community-based; Family approach; Health information system; Healthy family index |
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Institute of Advanced Engineering and Science |
22528806 |
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Article |
#N/A |
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381 |
Chikih C., Suryokusumo G., Sulistomo A. |
57222637163;57205444996;57024018500; |
Effect of acute submaximal physical exercise before decompression dive on tumor necrosis factor alpha concentration among male trained divers |
2021 |
International Journal of Public Health Science |
10 |
2 |
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289 |
297 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103567616&doi=10.11591%2fijphs.v10i2.20666&partnerID=40&md5=8c8626032d01ce9797442118fb643071 |
Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Klinik Hijau Putih 29, Primary Health Care Provider, Indonesia |
Chikih, C., Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Klinik Hijau Putih 29, Primary Health Care Provider, Indonesia; Suryokusumo, G., Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Sulistomo, A., Postgraduate Program Occupational Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia |
The increase of inflammatory biomarkers due to decompression dive is one of the factors that could cause decompression sickness (DCS), one of them is tumor necrosis alpha (TNFα). According to the preconditioning theory, exercise before dive can reduce amount of gas bubble to prevent DCS. This study aimed to prove that exercise before diving can prevent increase of TNFα. This study employed quasi-experimental design with trained male divers. The subject divided into two groups, treatment and control. The treatment group got submaximal exercise with 70% heart rate intensity, using cycle ergometer with young men's Christian association (YMCA) procedure modify by Guritno, 24 hours before decompression dive 280 kPa bottom time 80 minute with US-NAVY table, whereas the control group only do decompression dive. TNFα expression was checked three times, at beginning of study, before dive and after dive. In treatment group there was insignificant decrease TNFα, from 7.06±1.85pg./ml to 6.75±1.81pg./ml, whereas the control group showed a significant increased TNFα, from 8.22 (1.45 to 13.11)pg./ml to 8.39 (1.73 to 12.18)pg/ml, and significant difference was found between the mean difference for two groups p<0.05. It can be concluded that acute submaximal exercise prevents an increase of TNFα after single dive decompression to prevent possibility occurring DCS). © 2021, Institute of Advanced Engineering and Science. All rights reserved. |
Decompression dive; Physical exercise; Preconditioning; Prevention of DCS; TNFα |
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Institute of Advanced Engineering and Science |
22528806 |
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#N/A |
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385 |
Silalahi T., Alwi I., Suyatna F., Sartika K.D. |
56275255400;15055173800;57303311300;57221849323; |
Curcumin's Effect on Inflammatory Response following Percutaneous Coronary Intervention in Adult Patients with Stable Coronary Heart Disease |
2021 |
International Journal of Angiology |
30 |
2 |
200063 |
132 |
138 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100412387&doi=10.1055%2fs-0040-1720969&partnerID=40&md5=d55e2b0c365eafd1a179c7602474794d |
Division of Cardiovascular, Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Cipto Mangunkusumo National General Hospital, Arjuna Utara Street No. 6, Duri Kepa, Kebon Jeruk, Jakarta, 11510, Indonesia; Division Cardiovascular, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Silalahi, T., Division of Cardiovascular, Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Cipto Mangunkusumo National General Hospital, Arjuna Utara Street No. 6, Duri Kepa, Kebon Jeruk, Jakarta, 11510, Indonesia; Alwi, I., Division Cardiovascular, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Suyatna, F., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sartika, K.D., Division of Cardiovascular, Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Cipto Mangunkusumo National General Hospital, Arjuna Utara Street No. 6, Duri Kepa, Kebon Jeruk, Jakarta, 11510, Indonesia |
Cardiovascular diseases play major roles in the health problems worldwide especially in Indonesia. Percutaneous coronary intervention (PCI) is a minimally invasive procedure with relatively low complications. However, high inflammatory response post-PCI has showed adverse events even after administration of standard medication. Previous studies showed that curcumin was able to reduce inflammatory response in adult patients with stable coronary heart disease (CHD). This article determines the efficacy of oral administration of curcumin in reducing inflammatory response post-PCI with stable CHD. A double-blind randomized controlled trial on 50 adult patients comparing curcumin and placebo was performed in Cipto Mangunkusumo General Hospital and Jakarta Heart Center within April and June 2015. Either curcumin (45 mg/day) or placebo was given 7 days prior to PCI until 2 days after PCI. Inflammatory markers (high-sensitivity C-reactive protein [hsCRP] and soluble CD40 ligand [sCD40L]) were measured in three phases (7 days prior PCI, 24 hours post-PCI, and 48 hours post-PCI). There were no significant differences in the reduction of hsCRP and sCD40L between curcumin and placebo groups in three phases of measurement. Curcumin significantly reduce the serum hsCRP (p = 0.006) and sCD40L (p = 0.002) 7 days before PCI to 48 hours post-PCI. The decrement of hsCRP (-14.2% vs. -7.4%) and sCD40L (-24.3% vs. -13.2%) from 24 to 48 hours post-PCI was higher in the curcumin group than placebo group. The administration of curcumin 45 mg dose daily for 7 days prior PCI until 48 hours post-PCI is useful in reducing inflammatory response post-PCI with stable CHD. © 2020. International College of Angiology. All rights reserved. |
curcumin; inflammatory response; PCI; stable CHD |
acetylsalicylic acid; C reactive protein; CD40 ligand; clopidogrel; curcumin; placebo; adult; Article; clinical article; controlled study; dose response; double blind procedure; drug efficacy; female; human; human tissue; inflammatory disease; ischemic heart disease; male; measurement; middle aged; percutaneous coronary intervention; priority journal; protein blood level; randomized controlled trial; treatment response |
Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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386 |
Oike T., Uchihara Y., Permata T.B.M., Gondhowiardjo S., Ohno T., Shibata A. |
36453136000;57221723636;57197808751;6508327402;35395665700;8323572900; |
Quantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy |
2021 |
Medical Molecular Morphology |
54 |
2 |
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166 |
172 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099941107&doi=10.1007%2fs00795-020-00277-z&partnerID=40&md5=67d2ba3ce4cc88d92e3e071747ee2f42 |
Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia |
Oike, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia; Ohno, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan |
To obtain quantitative volumetric data for the Golgi apparatus after ionizing radiation (IR) using super-resolution three-dimensional structured illumination (3D-SIM) microscopy. Normal human retinal pigment epithelial (RPE) cells were irradiated with X-rays (10 Gy), followed by immunofluorescence staining of the Golgi marker RCAS1. 3D-SIM imaging was performed using DeltaVision OMX version 4 and SoftWoRx 6.1. Polygon rendering and spot signal identification were performed using Imaris 8.1.2. Differences between groups were assessed by Welch’s t test. RCAS1 signals in untreated cells were located adjacent to nuclei and showed a reticular morphology. Upon IR, the area of RCAS1 signals expanded while retaining the reticular morphology. Polygon rendering imaging revealed that the volume of RCAS1 at 48 h post-IR was greater than that for unirradiated cells (93.7 ± 19.0 μm3 vs. 33.0 ± 4.2 μm3, respectively; P < 0.001): a 2.8-fold increase. Spot signal imaging showed that the number of RCAS1 spot signals post-IR was greater than that for unirradiated cells [3.4 ± 0.8 (× 103) versus 1.3 ± 0.2 (× 103), respectively; P < 0.001]: a 2.7-fold increase. This is the first study to report quantitative volumetric data of the Golgi apparatus in response to IR using super-resolution 3D-SIM microscopy. © 2021, The Author(s). |
3D-SIM; Golgi; Ionizing radiation; RCAS1; Super-resolution microscopy |
article; controlled study; Golgi complex; human; human experiment; immunofluorescence; ionizing radiation; microscopy; quantitative analysis; retina pigment cell; signal transduction; vision; X irradiation; X ray; cell culture technique; epithelium cell; fluorescence microscopy; Golgi complex; procedures; radiation response; retina; three-dimensional imaging; ultrastructure; X ray; Cell Culture Techniques; Epithelial Cells; Golgi Apparatus; Humans; Imaging, Three-Dimensional; Microscopy, Fluorescence; Retina; X-Rays |
Springer Japan |
18601480 |
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33501611 |
Article |
Q2 |
650 |
7736 |
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423 |
Sitohang I.B.S., Rahmayunita G., Hosfiar V.A., Ninditya S., Augustin M. |
56734569200;57192909174;57219421454;57216741327;57219417020; |
Effectiveness of water as the neutralising agent for glycolic acid peels in skin phototypes IV-V |
2021 |
Australasian Journal of Dermatology |
62 |
2 |
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e212 |
e216 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092675176&doi=10.1111%2fajd.13486&partnerID=40&md5=a36758f77d6cfee5443e0a9ae6f60fed |
Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Sitohang, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rahmayunita, G., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hosfiar, V.A., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ninditya, S., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Augustin, M., Department of Dermatology and Venereology, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
The aim of the study is to evaluate the effectiveness of water as a substitute for sodium bicarbonate plus solution in the neutralisation process of chemical peeling using a 35% glycolic acid solution. This randomised, double-blind, split-face, controlled trial was conducted in an outpatient setting. A total of 126 healthy patients with skin phototypes IV–V aged between 18 and 60 years old were recruited. Chemical peeling was performed with 35% glycolic acid solution. One side of the face was neutralised with water, and the other side of the face was neutralised with a sodium bicarbonate plus solution. The main outcome of this study was measured by the degree of erythema, pruritus and pain scores. Significant difference in the pain score immediately after the neutralisation process of the chemical peeling with glycolic acid was seen. However, there were no significant differences in the degree of erythema or the pruritus score. These results indicate that water can be used as a substitute for sodium bicarbonate plus solution in the neutralisation process of chemical peeling with 35% glycolic acid in patients with skin phototypes IV–V. © 2020 The Australasian College of Dermatologists |
chemexfoliation; glycolic acid peel; skin phototypes IV–V; sodium bicarbonate; split face; water |
bicarbonate; glycolic acid; water; bicarbonate; buffer; keratolytic agent; adult; Article; chemexfoliation; clinical effectiveness; clinical protocol; Clinician Erythema Assessment scale; controlled study; cutaneous parameters; disease severity; documentation; double blind procedure; erythema; female; human; human experiment; male; middle aged; normal human; photosensitivity; pruritus; randomized controlled trial; rating scale; scoring system; visual analog scale; young adult; chemexfoliation; procedures; Adult; Buffers; Chemexfoliation; Double-Blind Method; Female; Glycolates; Humans; Keratolytic Agents; Male; Middle Aged; Sodium Bicarbonate; Water; Young Adult |
John Wiley and Sons Inc |
00048380 |
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33070326 |
Article |
Q2 |
670 |
7459 |
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429 |
Ocviyanti D., Putri R.A. |
57189661230;57226166006; |
Biopsychosocial aspect of pregnant women suspected brainstem death [Aspek Biopsikososial pada Perempuan Hamil dengan Kecurigaan Mati Batang Otak] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
2 |
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107 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115419653&doi=10.32771%2finajog.v9i2.1269&partnerID=40&md5=41a14ffbc68b4ced0cd44396ae92afad |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Ocviyanti, D., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: Diagnosis of brainstem death and the vital organ function support in the pregnant woman to prolong gestation to attain fetal viability is still controversial. The decision is influenced by ethical and legal issue in the country. Another consideration is the hospital cost and health insurance coverage. This article purpose is to report a case and discuss the biopsychosocial aspect of this issue, so the doctors know how to decide a similar case. Methods: We reported a suspected brainstem death in pregnant women and discussed the holistic approach. Case: This case is a-38-year-old women, third pregnancy, 22 weeks of gestation, referred from the secondary hospital in a comatose condition. She was diagnosed with brainstem dysfunction due to intracranial mass and cerebral oedema. She wasn't diagnosed with brainstem death due to the electrolyte imbalance that can cause this condition. We did the multidisciplinary management approach. We decided the termination of pregnancy would only be performed if the fetus reaches 28 weeks of gestational age (with survival rate on perinatology is 31%). From the husband point of view, since the attending doctors have not declared the mother to be dead, then the husband still want to keep the mother in full life support. The patient and the fetus died on the 8th day of hospitalization. The patient was fully paid for by Indonesian Health Insurance. Conclusions: Maternal brainstem dysfunction and brainstem death during pregnancy are rare. In Indonesia, ethical and legal consideration to keep both mother and fetus are appropriate with the general social, cultural, and religious values. However, we recommend managing every single case individually with an intensive multidisciplinary approach due to the possibility of the different personal value of the patient. © Creative Commons Atribuição-Não Comercial 4.0 Internacional |
Brain death; Brainstem dysfunction; Ethic; Fetal; Legal; Pregnancy |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
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430 |
Mariati N.M.A.S., Sugiarto A., Endriani E., Lestari R., Anindita K. |
57223228784;57189612291;57222314378;57223220725;57192903786; |
High flow nasal cannula to prevent intubation in obese patient with COVID-19 induced ARDS: a case report |
2021 |
Anaesthesia, Pain and Intensive Care |
25 |
2 |
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212 |
216 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105281913&doi=10.35975%2fAPIC.V25I2.1473&partnerID=40&md5=2108db369e86e24a12b1ed89d9a0970b |
Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Mariati, N.M.A.S., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Endriani, E., Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Lestari, R., Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Anindita, K., Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Obese patients have been identified to have a poor prognosis and a higher risk of death from coronavirus disease-2019 (COVID-19). We present reports of two obese patients infected with COVID-19 with acute respiratory distress syndrome (ARDS) who showed improvement with high flow nasal cannula (HFNC). HFNC is a noninvasive oxygen delivery device which is capable of delivering a high concentration of oxygen that can reduce the requirement for tracheal intubation. HFNC is convenient to use, can reduce dyspnea without effecting the length of stay in ICU in these cases; and has a high merit to be used in selected patients requiring oxygen before attempting intubation and mechanical ventilation. © the authors. |
ARDS; COVID-19; HFNC; High flow nasal cannula; Obese |
alanine aminotransferase; antiarrhythmic agent; ascorbic acid; aspartate aminotransferase; azithromycin; C reactive protein; chloroquine; dexamethasone; famotidine; heparin; hypertensive factor; levofloxacin; low molecular weight heparin; methylprednisolone; micafungin; oseltamivir; remdesivir; SARS-CoV-2 convalescent plasma; vancomycin; adult; adult respiratory distress syndrome; ageusia; alanine aminotransferase blood level; anosmia; Article; artificial ventilation; aspartate aminotransferase blood level; case report; clinical article; coronavirus disease 2019; coughing; COVID-19 testing; crackle; diarrhea; drug withdrawal; dyspnea; endotracheal intubation; fever; heart arrhythmia; high flow nasal cannula therapy; hospital admission; human; hypotension; hypoxemia; intensive care unit; le |
Faculty of Anaesthesia, Pain and Intensive Care, AFMS |
16078322 |
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Article |
Q3 |
170 |
21404 |
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431 |
Marzuki N.S., Idris F.P., Kartapradja H., Renata S., Harahap A., Latief Batubara J.R. |
37111053300;57224096699;6504373157;57224098534;6507325543;57224097014; |
Accuracy of urinary etiocholanolone/androsterone ratio as alternative to serum testosterone/dihydrotestosterone ratio for diagnosis of 5 alpha-reductase type 2 deficiency patients and carriers in Indonesia |
2021 |
International Journal of Endocrinology and Metabolism |
19 |
2 |
e109510 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106858176&doi=10.5812%2fIJEM.109510&partnerID=40&md5=262ad88d94d397f7bc55e0ace31050be |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Marzuki, N.S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Idris, F.P., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Kartapradja, H., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Renata, S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Harahap, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Latief Batubara, J.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The 5 Alpha-reductase type 2 deficiency (5ARD2) is an inherited condition, which clinically presents as variable degrees of under virilization in affected 46,XY individuals. In the diagnostic pathway of 5ARD2, the testosterone/dihydrotestosterone (T/DHT) ratio is broadly employed before molecular analysis of the SRD5A2 gene. However, due to cost-benefit considerations, the DHT test in our country is routinely lacking in clinical settings; therefore, we considered applying the urinary etiocholanolone/androsterone (Et/An) ratio as an alternative test. Objectives: We aimed to determine the diagnostic value of the urinary Et/An ratio versus the T/DHT ratio in diagnosing 5ARD2 patients and carriers. Methods: Sixty-six suspected 5ARD2 46,XY disorders of sex development (DSD) individuals and 95 family members were recruited in the study. Their clinical manifestations, T/DHT and urinary Et/An ratios, and SRD5A2 genes were analyzed. Using molecular analysis of the SRD5A2 gene as the gold standard, we compared the accuracy of both ratios in diagnosing 5ARD2 patients and carriers with receiver operating characteristic (ROC) curve analysis. Results: Thirty-seven patients were confirmed molecularly to have 5ARD2, and the rest (n = 29) were assessed as normal controls, while in the carrier group, 53 were molecularly confirmed as carriers and 42 as controls. The AUCs (areas under the curve) of the T/DHT and urinary Et/An ratios were 57.7% (95% CI 43.0 - 72.4%, P > 0.05) and 79.7% (95% CI 69.0 - 90.4%, P < 0.001), respectively, in diagnosing 5ARD2 patients and 54.1% (95% CI 42.4 - 65.8%, P > 0.05) and 75.1% (95% CI 65.1 - 85.1%, P < 0.001), respectively, in diagnosing carriers. The cutoff value of the urinary Et/An ratio was set at ≥ 0.95 for detecting 5ARD2 patients and ≥ 0.99 for detecting carriers. Conclusions: The testosterone/DHT ratio was inaccurate in diagnosing 5ARD2 patients. When molecular analysis for the SRD5A2 gene is lacking, the urinary Et/An ratio may be a useful test to diagnose 5ARD2 patients and carriers. Copyright © 2021, International Journal of Endocrinology and Metabolism. |
46; 5 Alpha-reductase 2 deficiency; Androsterone; Dihydrotestosterone; Etiocholanolone; SRD5A2; Testosterone; XY DSD |
androstanolone; androsterone; chorionic gonadotropin; etiocholanolone; genomic DNA; steroid; steroid 5alpha reductase 2; testosterone; 5 alpha reductase deficiency; adolescent; adult; analytical parameters; area under the curve; Article; child; clinical article; clinical assessment; clinical feature; competitive ELISA; controlled study; cost benefit analysis; diagnostic accuracy; diagnostic value; disorder of sex development; female; genetic analysis; hormone urine level; human; human tissue; Indonesia; infant; male; molecular biology; neutrophil lymphocyte ratio; newborn; receiver operating characteristic; serum testosterone dihydrotestosterone ratio; testosterone blood level; urinary etiocholanolone androsterone ratio |
Kowsar Medical Institute |
1726913X |
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Article |
Q3 |
652 |
7699 |
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439 |
Restuti R., Sriyana A., Priyono H., Saleh R. |
55261428300;57203022550;57201550021;57391850200; |
Postauricular Cutaneous Mastoid Fistula Closure with Combination of Bilobed Flap and Fibro-Muscular-Periosteal Flap: A Case Series |
2021 |
Indian Journal of Otology |
27 |
2 |
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116 |
119 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122022487&doi=10.4103%2findianjotol.indianjotol_10_21&partnerID=40&md5=dfd65407309ade3f15f32833b03bb0ef |
Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Restuti, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Sriyana, A., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Priyono, H., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Saleh, R., Department of Ear, Nose, Throat, Head and Neck Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine University of Indonesia, Jakarta, Indonesia |
Chronic suppurative otitis media (CSOM) with cholesteatoma can present with intratemporal complications such as postauricular subperiosteal abscess with or without fistula. In some postauricular cutaneous mastoid fistula cases, direct closure of the wound is not possible due to skin tension, leading to skin necrosis and postoperative recurrent cutaneous fistula. Here, we describe a surgical technique using a combination of a bilobed flap and a fibro-muscular-periosteal flap for fistula closure on a 31-year-old and a 35-year-old female with postauricular cutaneous mastoid fistula due to CSOM. All patients were successfully managed with no fistula recurrence. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Bilobed flap; cholesteatoma; chronic suppurative otitis media; postauricular cutaneous mastoid fistula |
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Wolters Kluwer Medknow Publications |
09717749 |
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Article |
Q4 |
174 |
21127 |
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