No records
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450 |
Pujianto D., Oktarina M., Sharma Sharaswati I., Yulhasri Y. |
8745734300;57225172840;57225177505;57225180520; |
Hydrogen peroxide has adverse effects on human sperm quality parameters, induces apoptosis, and reduces survival |
2021 |
Journal of Human Reproductive Sciences |
14 |
2 |
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121 |
128 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109421886&doi=10.4103%2fjhrs.jhrs_241_20&partnerID=40&md5=b51e205fbcc1300b22e8e8898e7a1c02 |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Pujianto, D., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktarina, M., Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sharma Sharaswati, I., Master Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: One of the causes of male fertility disorders is the exposure of oxidative stress on the human sperm. Understanding the mechanism of disturbance is important to develop a better treatment for infertile or subfertile patients. Aims: The aim of this study was to analyze the effects of hydrogen peroxide (H2O2) on human sperm quality parameters and cell survival. Settings and Design: This study used an experimental design. Materials and Methods: Sperm cells from 15 donors were washed in a Percoll gradient and dissolved in Biggers, Whitter, and Whittingham medium. Cells were incubated with H2O2at various concentrations from 0 to 250 μM for 2 h. Sperm viability was examined by eosin assay, sperm kinetic by computer-assisted sperm analyzer, sperm penetration by cervical mucus penetration assay, and membrane integrity by hypo-osmotic swelling test. Sperm capacitation, apoptosis, and cell survival were analyzed using western immunoblotting. Statistical Analysis Used: One-way ANOVA on SPSS 21 combined with post hoc LSD test was used to analyze differences among the groups. A P < 0.05 was considered significant. Results: Sperm viability and kinetic were significantly reduced at H2O2concentrations of 200 and 250 μM. H2O2reduced sperm capability to penetrate cervical mucus and also damage cell membrane integrity at all concentrations used. H2O2significantly inhibited sperm capacitation, indicated by reduced total tyrosine phosphorylation. H2O2exposure stimulated activation of caspase 3 and significantly reduced phosphorylated AKT at all concentrations used. Conclusions: H2O2comprehensively inhibits sperm qualities related to the capacity to fertilize oocyte, stimulates caspase activity, and inhibits cell survival. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
AKT; capacitation; caspase; hydrogen peroxide; sperm |
caspase 3; hydrogen peroxide; malonaldehyde; protein kinase B; adverse event; analysis of variance; apoptosis; Article; cell survival; clinical article; densitometry; human; human cell; immunoblotting; kinetics; lipid peroxidation; male; male infertility; oxidative stress; post hoc analysis; protein phosphorylation; sperm capacitation; sperm preparation; sperm quality; sperm viability; spermatozoon penetration; uterine cervix mucus |
Wolters Kluwer Medknow Publications |
09741208 |
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Article |
Q3 |
484 |
10359 |
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452 |
Jusuf A.A., Viventius Y., Djaali W. |
57192275719;57223088537;57212479564; |
Comparison between the effectiveness of manual acupuncture and laser acupuncture at ex-b3 weiwanxiashu in a rat model of type 2 diabetes |
2021 |
JAMS Journal of Acupuncture and Meridian Studies |
14 |
2 |
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75 |
81 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107546334&doi=10.51507%2fj.jams.2021.14.2.75&partnerID=40&md5=e5fc6b12ab3bd259eeccdf3c7d1658af |
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Universitas Negeri Jakarta, Jakarta, Indonesia |
Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Viventius, Y., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Acupuncture, RSUPN Dr. CiptoMangunkusumo, Jakarta, Indonesia; Djaali, W., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Universitas Negeri Jakarta, Jakarta, Indonesia |
Background: Diabetes mellitus (DM) is a chronic metabolic disease characterized by increased blood sugar levels. The current management of DM to date has a target of controlling blood glucose, but the therapy cannot be separated from long-term drug side effects. Acupuncture can be an option as an adjunct therapy for DM. Objectives: The purpose of this study was to compare the effectiveness between manual acupuncture and laser acupuncture. Methods: This study was a randomized control experimental study with a pretest and posttest design using 24 male Sprague-Dawley rats divided into 4 groups: A normal group, a diabetes group, an acupuncture group, and a laser group. Manual acupuncture and laser acupuncture were performed 6 times in two weeks. Fasting blood glucose (FBG) levels, the cell density of Langerhans islets, and side effects were assessed and compared among the 4 groups. Results: The highest mean cell density of Langerhans islets was found in the laser and acupuncture group, and the lowest was found in the diabetes group. In the post hoc analysis, the normal, acupuncture, and the laser groups had a significantly higher mean cell density than the diabetes group. The lowest mean FBG level was in the laser group, followed by the acupuncture group, and the highest was in the diabetes group, but this difference was not significant. There were no serious side effects from the use of manual acupuncture or laser acupuncture. Conclusion: Both manual acupuncture and laser acupuncture can improve the histological findings of Langerhans islets in type 2 diabetic rats, and both are safe to use. © 2021 Korean Pharmacopuncture Institute. All rights reserved. |
EX-B3; Laser acupuncture; Manual acupuncture; Type 2 diabetes |
glucose; acupuncture; acupuncture point; animal experiment; animal model; Article; cell density; comparative effectiveness; controlled study; erythema; fasting; glucose blood level; laser therapy; male; meichong acupoint; non insulin dependent diabetes mellitus; nonhuman; pancreas islet; post hoc analysis; rat; streptozotocin-induced diabetes mellitus |
Medical Association of pharmacopuncture Institute |
20052901 |
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Article |
Q2 |
374 |
12741 |
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453 |
Yani A., Dorothy D., Amaliah R. |
57215433374;57224003330;57224001785; |
Influence of Intestinal Strangulation Release on Ischemiareperfusion Injury in Sprague Dawley Rats |
2021 |
Annals of African Surgery |
18 |
2 |
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90 |
95 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106736281&doi=10.4314%2fAAS.V18I2.6&partnerID=40&md5=611bcf09b29bda5c9a4b2e09279bdd15 |
Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yani, A., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Dorothy, D., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Amaliah, R., Department of Surgery, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: In intestinal ischemia, reperfusion towards the injured intestine can cause further injury to the intestine itself and to remote organs. This research aimed to evaluate the influence of intestinal strangulation release (SR) before resection on the intestine outside margin of the strangulated intestine compared with subjects without intestinal strangulation release (WSR). Methods: Fourteen male Sprague Dawley rats were subjected to strangulation of one loop of the distal ileum for 4 h. In the SR group, the strangulated intestine was released for 5 min and then resected for necrotic parts. In the WSR group, the strangulated intestine was immediately resected WSR. The control group received a sham laparotomy. Four hours after the second laparotomy, the animals were sacrificed, and intestinal samples were taken for histomorphological analysis and measurement of intestinal malondialdehyde (MDA) level. Results: The injury on the histomorphological intestinal mucosa and intestinal MDA level were insignificantly higher in the SR group than in the WSR group (p>0.05). Conclusion: Intestinal SR before resection causes more tissue injury and oxidative stress on the intestine outside the strangulation section, but the difference is not statistically significant. © 2021 Surgical Society of Kenya. All rights reserved. |
Intestinal ischemia; Intestinal strangulation release; Intestine injury; Ischemia-reperfusion injury; Malondialdehyde |
ketamine; malonaldehyde; xylazine; animal experiment; animal model; animal tissue; Article; controlled study; histopathology; ileum; intestinal strangulation; intestine injury; intestine ischemia; intestine necrosis; laparotomy; male; nonhuman; oxidative stress; rat; reperfusion injury; sham procedure; small intestine obstruction; small intestine resection; Sprague Dawley rat |
Surgical Society of Kenya |
19999674 |
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Article |
Q4 |
114 |
27851 |
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455 |
Wang G., Tanaka A., Zhao H., Jia J., Ma X., Harada K., Wang F.-S., Wei L., Wang Q., Sun Y., Hong Y., Rao H., Efe C., Lau G., Payawal D., Gani R., Lindor K., Jafri W., Omata M., Sarin S.K. |
7407149871;57208572262;57200532284;57218488345;7404550067;57212924064;57216339526;7402950828;55531131800;56402234600;57188750283;8220686600;25122065500;36114075400;7801385732;23495930300;35418813000;23091123700;36043368300;57220191468; |
The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis |
2021 |
Hepatology International |
15 |
2 |
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223 |
257 |
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7 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105607533&doi=10.1007%2fs12072-021-10170-1&partnerID=40&md5=eef4f926d521f19ad391095aa3af27f0 |
Peking University First Hospital, Beijing, China; Teikyo University School of Medicine, Tokyo, Japan; Beijing Friendship Hospital, Capital Medical University, Beijing, China; Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Kanazawa, Japan; Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Beijing Tsinghua Changgung Hospital, Beijing, China; Peking University People’s Hospital, Beijing, China; Department of Gastroenterology, Harran University, Åžanlıurfa, Turkey; Humanity and Health Medical Group, Hong Kong; Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines; Department of Internal Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; College of Health Solutions, Arizona State University, Phoenix, AZ, United States; Aga Khan University, Karachi, Pakistan; Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Kofu-City, Yamanashi, Japan; The University of Tokyo, Tokyo, Japan; Institute of Liver and Biliary Sciences, New Delhi, India; Peking University International Hospital, Beijing, China |
Wang, G., Peking University First Hospital, Beijing, China, Peking University International Hospital, Beijing, China; Tanaka, A., Teikyo University School of Medicine, Tokyo, Japan; Zhao, H., Peking University First Hospital, Beijing, China, Peking University International Hospital, Beijing, China; Jia, J., Beijing Friendship Hospital, Capital Medical University, Beijing, China; Ma, X., Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Harada, K., Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Kanazawa, Japan; Wang, F.-S., Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Wei, L., Beijing Tsinghua Changgung Hospital, Beijing, China; Wang, Q., Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Sun, Y., Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Hong, Y., Peking University First Hospital, Beijing, China; Rao, H., Peking University People’s Hospital, Beijing, China; Efe, C., Department of Gastroenterology, Harran University, Åžanlıurfa, Turkey; Lau, G., Humanity and Health Medical Group, Hong Kong; Payawal, D., Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines; Gani, R., Department of Internal Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Lindor, K., College of Health Solutions, Arizona State University, Phoenix, AZ, United States; Jafri, W., Aga Khan University, Karachi, Pakistan; Omata, M., Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Kofu-City, Yamanashi, Japan, The University of Tokyo, Tokyo, Japan; Sarin, S.K., Institute of Liver and Biliary Sciences, New Delhi, India |
[No abstract available] |
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6 mercaptopurine derivative; azathioprine; budesonide; corticosteroid; cyclosporine; farnesoid X receptor; infliximab; mycophenolate mofetil; prednisone; rapamycin; tacrolimus; antibody detection; Asia; autoimmune hepatitis; autoimmunity; cataract; chronic liver disease; clinical practice; cytokine production; decompensated liver cirrhosis; diabetes mellitus; disease predisposition; drug efficacy; drug exposure; drug safety; dual energy X ray absorptiometry; environmental factor; gene locus; genetic susceptibility; geographic distribution; human; hypertension; immunoglobulin blood level; immunological tolerance; immunoregulation; incidence; liver biopsy; liver cell carcinoma; liver transplantation; magnetic resonance elastography; nonalcoholic fatty liver; Note; osteoporosis; Pacific islan |
Springer |
19360533 |
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33942203 |
Note |
Q2 |
1304 |
2874 |
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456 |
Bahtiar A., Setyowati H., Mahanani R., Wati A., Arsianti A., Fadilah F. |
35365874400;57223255498;57223266884;57223271215;36124567000;56966708600; |
Rhaponticin contained Rheum officinale root extract improved Postmenopause symptom of Ovariectomized Rat |
2021 |
Journal of Advanced Pharmaceutical Technology and Research |
12 |
2 |
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175 |
179 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105384592&doi=10.4103%2fjaptr.JAPTR_324_20&partnerID=40&md5=1f1fbda205bf337ab7c1628298d5d1ba |
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia |
Bahtiar, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Setyowati, H., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Mahanani, R., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Wati, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI, Depok, 16424, Indonesia; Arsianti, A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia; Fadilah, F., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Jl, Salemba Raya, Jakarta, Indonesia |
Postmenopausal women have decreased levels of the hormone estrogen. Reduced estrogen levels will often involve many symptoms that reduced quality of life. This research aims to analyze the effects of Rheum officinale root extract on postmenopausal model rats. To this end, thirty rats underwent ovariectomy (OVX) surgery and six rats were operated without having their ovaries removed. The OVX was confirmed by body weight-uterus weight ratio and a vaginal swab. Six groups of the rats were performed: SHAM group and negative control groups are given vehicle; the positive control was assigned tamoxifen; and the extract has been given three doses 7, 35, and 175 mg/200 g BW, respectively, for 30 days. The calcium content of bone ash was measured using atomic absorption spectrophotometer. Blood pressure was evaluated using CODA®, and the metabolites in the blood were assessed using gas chromatography-mass spectrometry (MS) and high-performance liquid chromatography. As a result, using ultra-performance liquid chromatography (UPLC)-MS, we found that the extract's major component was rhaponticin and its metabolites. The bone calcium levels increased with increasing doses of the extract. In the OVX group, the bone calcium content was decreased significantly 51.56% ± 8.9% g compared with the SHAM group 62.97% ±5.6% g, and the administration of Rheum extract could restore the calcium content of the bone to become 69.27% ± 3.8% g. From the above data, we concluded that Rheum root extracts contain astrigin, rhaponticin, rhapontigenin, and desoxyrhaponticin. Rheum root extract could improve calcium content and lipid profiles of OVX rats by stimulation osteoblastogenesis. Rheum root extracts could control the blood pressure of OVX rats by reducing lipid profiles. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Calcium; hypertension; Kalembak; lipid profiles; osteoporosis; postmenopausal; rhaponticin; Rheum officinale |
antihypertensive agent; astringin; calcium; cholesterol; desoxyrhaponticin; high density lipoprotein; low density lipoprotein; rhapontigenin; rhapontin; Rheum officinale extract; tamoxifen; triacylglycerol; unclassified drug; analytical parameters; animal experiment; animal model; animal tissue; antihypertensive activity; Article; atomic absorption spectrometry; blood pressure measurement; body weight; body weight gain; body weight uterus weight ratio; bone density; calcium bone level; comparative study; controlled study; diastolic blood pressure; drug effect; female; high performance liquid chromatography; hypertension; Indonesia; lipid fingerprinting; mass fragmentography; nonhuman; ovariectomy; plant root; postmenopause; priority journal; protein analysis; rat; rat model; retention time |
Wolters Kluwer Medknow Publications |
01105558 |
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Article |
Q3 |
325 |
14045 |
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458 |
Maya E., Viventius Y., Simadibrata C.L., Mihardja H.M. |
57223091162;57223088537;57194343459;57195721818; |
How Do You Treat Psoriasis in Your Practice? (1) |
2021 |
Medical Acupuncture |
33 |
2 |
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176 |
177 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104761989&doi=10.1089%2facu.2021.29172.cpl&partnerID=40&md5=e14f9573d53cf3e921e8ec273656b471 |
Medistra Hospital, Jl. Gatot Subroto No. 59, RW 4, Kuningan Tim., Kota Jakarta Selatan, Daerah Khusus Ibukota, 12950, Indonesia; Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia; Center of Development and Application of Traditional Medicine, Daerah Khusus Ibukota, Jakarta, 10160, Indonesia |
Maya, E., Medistra Hospital, Jl. Gatot Subroto No. 59, RW 4, Kuningan Tim., Kota Jakarta Selatan, Daerah Khusus Ibukota, 12950, Indonesia; Viventius, Y., Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia; Simadibrata, C.L., Medical Acupuncture Specialist Program, Faculty of Medicine Universitas Indonesia, Daerah Khusus Ibukota, Jakarta, 10430, Indonesia; Mihardja, H.M., Center of Development and Application of Traditional Medicine, Daerah Khusus Ibukota, Jakarta, 10160, Indonesia |
[No abstract available] |
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methotrexate; acupuncture; acupuncture point; adult; case report; clinical article; dermatologist; female; hospital admission; human; medical history; Note; physical examination; priority journal; psoriasis; Psoriasis Area and Severity Index |
Mary Ann Liebert Inc. |
19336586 |
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Note |
Q2 |
281 |
15498 |
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459 |
Muchtar N.J., Helianthi D.R., Nareswari I. |
57216550449;57194729482;57194336586; |
Effectiveness of Electroacupuncture for Management of Young Patients with Overactive Bladder at 1-Year Follow-Up |
2021 |
Medical Acupuncture |
33 |
2 |
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169 |
174 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104703311&doi=10.1089%2facu.2020.1462&partnerID=40&md5=14af8a2c96999e7428dd5cd493b4ac4d |
Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia |
Muchtar, N.J., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia; Helianthi, D.R., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia; Nareswari, I., Department of Medical Acupuncture, Faculty of Medicine, Universitas Indonesia, Jakarta, Daerah Khusus Ibukota Jakarta, Indonesia |
Background: Overactive bladder (OAB) is defined as urgency (a sudden compelling desire to pass urine with or without urge incontinence) usually associated with frequency and nocturia. OAB is a chronic condition that affects quality of life (QoL) significantly in patients. Acupuncture can help in the treatment of OAB for patients who cannot take certain medications. Case: A 32-year-old a female patient was diagnosed with OAB. She came to the department of medical acupuncture with a chief complaint of frequent urination for 15 years. Urinalysis test results were normal. Before acupuncture, a bladder ultrasound (US) showed a postvoid residual volume (PVR) of 53 mL, and a uroflowmetry test showed a maximum flow rate of 20.6 mL/s, with an average flow rate of 12.1 mL/s and a voided volume of 71 mL. Her OAB Symptom Score (OABSS) was 13 and the King's Health Questionnaire result was (KHQ) was 87. She was treated with electroacupuncture (EA). Results: After 12 EA sessions, 3 times per week, this patient's bladder US showed a PVR of 3 mL; a uroflowmetry test showed a maximum flow rate of 30.5 mL/s, with an average flow rate of 15.3 mL/s and a voided volume of 120 mL. Her OABSS score was 7. Her KHQ score was 0. Conclusions: OAB can be treated with EA to improve QoL, as seen by this patient's decreasing OABSS and KHQ scores, reduced PVR, and increase the voided volume. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
acupuncture; bladder hyperactivity; electroacupuncture; incontinence; nocturia; Overactive bladder |
albumin; bilirubin; glucose; ketone; urobilinogen; abdominal surgery; adult; appendicitis; Article; asepsis; case report; cesarean section; clinical article; echography; electroacupuncture; female; flow rate; follow up; human; informed consent; laboratory test; micturition; overactive bladder; patient comfort; pollakisuria; postvoid residual urine volume; priority journal; social life; urinalysis; uroflowmetry; vaginal delivery; voided volume |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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464 |
Cahyono A.T., Louisa M., Mayang Permata T.B., Handoko, Nuryadi E., Kodrat H., Wibowo H., Hariandy Hamid A.R.A., Sekarutami S.M., Gondhowiardjo S.A. |
57222900545;41461551400;57197808751;57209984822;57197806814;57210639849;57217690943;57202054669;56576294500;6508327402; |
The potential of gallic acid as a radiosensitizer on human prostate cancer: A systematic review of preclinical studies |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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246 |
254 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104201486&partnerID=40&md5=aff7e4b57216dc4b88ee83f02823372e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Cahyono, A.T., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mayang Permata, T.B., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, H., Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hariandy Hamid, A.R.A., Department of Urology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Prostate adenocarcinoma accounts for majority of prostate cancer cases, and it was found to be highly radioresistant. Gallic acid is a phenolic acid naturally occurring in many plants, reported to exhibit biological activities in eliminating cancer cell lines and xenografts. The purpose of this study is to review gallic acid as a potential radiosensitizer agent in prostate cancer treatment. Article search was conducted in PubMed, EBSCO, and Scopus. 11 studies using different cell lines including DU145, PC-3, LNCaP, and 22Rv1 xenograft of human prostate cancer were reviewed in this paper. Gallic acid acts as a radiosensitizer mainly by increasing caspase-3 and caspase-9 activation resulting in apoptosis, while also reducing intracellular CDKs, cyclins, and cdc25 phosphatases ultimately causing G2-M cell cycle arrest. Gallic acid has a potential to be a new radiosensitizer compound in prostate cancer treatment. Additional clinical studies using gallic acid derivatives with lower hydrophilicity are needed. © 2021 UPM Press. All rights reserved. |
Apoptosis; Gallic acid; Prostate cancer; Radiobiology; Radiotherapy |
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Universiti Putra Malaysia Press |
16758544 |
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Review |
Q4 |
144 |
23823 |
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465 |
Mochtar I., Adi N.P., Hardjono A.W., Mansyur M. |
57222902121;57023786200;57222902350;37085506800; |
Return to work assessment in a radiographer assistant suffering a hemianopsia due to an ischemic stroke |
2021 |
Malaysian Journal of Medicine and Health Sciences |
17 |
2 |
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301 |
304 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104187321&partnerID=40&md5=cad74495ef91661c388194494f7d4e58 |
Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia |
Mochtar, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Adi, N.P., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia; Hardjono, A.W., Indonesian Occupational Medicine Specialist Association, Jakarta, 10350, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia, Occupational and Environmental Health Research Cluster, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10320, Indonesia |
Return to work assessment (RTWA) has been performed to a radiographer assistant suffering a hemianopsia due to an ischemic stroke. Stroke occurred two months prior to the examination. The general condition of the patient was good. The systemic examination was unremarkable except the presence of a partial vision loss in the left eye and often feeling fatigue and down. Perimetry Full-field 120 Point Screening Test confirmed a left temporal hemianopsia while Patient Health Questionnaire’s score (PHQ-9) indicated a moderate depression. The two conditions were not fully compatible with the job demand of a radiographer assistant, which required a complete and clear visual field as well as a good mental status. Risk assessment indicated that the patient might encounter health and safety issues if he resumed duty without work adjustment. The clinic still wanted to employ the patient and agreed to provide support. The patient was declared ‘fit’ to resume his duty with some recommendations. © 2021 UPM Press. All rights reserved. |
Hemianopsia; Return to work; Stroke |
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Universiti Putra Malaysia Press |
16758544 |
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Article |
Q4 |
144 |
23823 |
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480 |
Sukmawan R., Hoetama E., Suridanda Danny S., Giantini A., Listiyaningsih E., Gilang Rejeki V., Aziz Alkatiri A., Firdaus I. |
8651025300;57214138849;57222312102;12776781400;57224237184;57222313503;57222311692;55796864700; |
Increase in the risk of clopidogrel resistance and consequent TIMI flow impairment by DNA hypomethylation of CYP2C19 gene in STEMI patients undergoing primary percutaneous coronary intervention (PPCI) |
2021 |
Pharmacology Research and Perspectives |
9 |
2 |
e00738 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102225470&doi=10.1002%2fprp2.738&partnerID=40&md5=444f8c3e75e75ed786eedbe412614a0b |
Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Jakarta, Indonesia; Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Sukmawan, R., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Hoetama, E., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Suridanda Danny, S., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Giantini, A., Clinical Pathology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Public Hospital, Jakarta, Indonesia; Listiyaningsih, E., Indonesian Cardiovascular Research Center, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Gilang Rejeki, V., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Aziz Alkatiri, A., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Firdaus, I., Cardiology and Vascular Medicine Department, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Clopidogrel resistance is an important risk factor of ischemic event recurrence after optimal antiplatelet therapy. This study aims to investigate the role of CYP2C19 gene DNA methylation as one of the epigenetic factors for the risk of clopidogrel resistance in STEMI patients undergoing PPCI. ST-segment elevation myocardial infarction (STEMI) patients undergoing PPCI were pretreated with clopidogrel, and their platelet function was measured using VerifyNow™ assay. The criteria for high on-treatment platelet reactivity (HPR) were defined according to the expert consensus criteria (PRU >208). DNA methylation of the CYP2C19 gene was performed using bisulfite genomic sequencing technology. Furthermore, clinical, laboratory, and angiographic data including TIMI flow were collected. Among 122 patients, clopidogrel resistance was found in 22%. DNA methylation level percentage was lower in the clopidogrel resistance group (76.7 vs. 88.8, p-value.038). But, the <50% methylation group was associated with increased risk of clopidogrel resistance (OR =4.5, 95%CI =2.1–9.3, p-value =.018). This group was also found to have suboptimal post-PCI TIMI flow (OR =3.4 95%CI =1.3–8.7, p-value =.045). The lower DNA methylation level of the CYP2C19 gene increases the risk of clopidogrel resistance and subsequent poorer clinical outcome. © 2021 The Authors. Pharmacology Research & Perspectives published by British Pharmacological Society and American Society for Pharmacology and Experimental Therapeutics and John Wiley & Sons Ltd. |
acute coronary syndrome; clopidogrel resistance; CYP2C19; DNA methylation |
acetylsalicylic acid; clopidogrel; cytochrome P450 2C19; clopidogrel; CYP2C19 protein, human; cytochrome P450 2C19; aged; angiography; blood clotting parameters; Cytochrome P450 2C19 gene; diabetes mellitus; DNA methylation; echocardiography; female; human; loading drug dose; major clinical study; male; percutaneous coronary intervention; Review; ST segment elevation myocardial infarction; adult; complication; drug effect; drug resistance; fibrinolytic therapy; genetics; metabolism; middle aged; percutaneous coronary intervention; procedures; recurrent disease; secondary prevention; ST segment elevation myocardial infarction; thrombocyte aggregation; Adult; Clopidogrel; Cytochrome P-450 CYP2C19; DNA Methylation; Drug Resistance; Female; Humans; Male; Middle Aged; Percutaneous Coronary Inte |
John Wiley and Sons Inc |
20521707 |
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33641235 |
Review |
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975 |
4541 |
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