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566 |
Hariyanto N.I., Purwandhita R.P., Syahrani R.A., Louisa M., Wanandi S.I. |
57222706851;57202377042;57204103147;41461551400;36099320700; |
Role of TGF-?1 in human breast cancer stem cells |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
|
S84 |
S89 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103745958&partnerID=40&md5=425118184fecd5818a6435ec48e67ad8 |
Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia; Department of Molecular Biology and Proteomics, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Universitas Indonesia, Jakarta, Indonesia; Department of BioChemistry and Molecular Biology, Universitas Indonesia, Jakarta, Indonesia |
Hariyanto, N.I., Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia; Purwandhita, R.P., Department of Molecular Biology and Proteomics, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Syahrani, R.A., Department of Pharmacology, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of BioChemistry and Molecular Biology, Universitas Indonesia, Jakarta, Indonesia; Wanandi, S.I., Master Program in BioMedical Sciences, Universitas Indonesia, Jakarta, Indonesia |
Objective: To investigate the auto-induction of transforming growth factor-b1 (TGF-?1) in breast cancer stem cells (BCSCs) and its effect on cell viability and stemness. Methods: Human BCSCs (aldehyde dehydrogenase positive; ALDH+) were grown in serum-free Dulbecco's Modified Eagle Medium/Nutrient Mixture F12 (DMEM/F12) and treated for periods of 1, 2 and 4 hours with 0.1 ng/ml recombinant human TGF-?1 protein (rhTGF-?1). The medium was then replaced with serum-free DMEM/F12 without rhTGF-?1 for 24 hours. Cell viability was determined using a trypan blue exclusion assay. Type 1 TGF-? receptor (T?R1), TGF-?1, octamer-binding transcription factor 4 (OCT4) and aldehyde dehydrogenase 1 family member A1 (ALDH1A1) messenger RNA (mRNA) expression levels were analysed using quantitative real-Time reverse-Transcriptase polymerase chain reaction (RT-qPCR). The TGF-? protein level in the culture medium was determined using an enzyme-linked immunosorbent assay (ELISA). Results: The expression levels of rhTGF-?1, TGF-?1 and T?R1 mRNA significantly increased in BCSCs compared to control after treatment for 1 and 2 hours but decreased after 4 hours. This is in line with alteration of stemness gene, OCT4 and ALDH1A1 mRNA expressions. However, the secretion of newly synthesised TGF-?1 significantly increased after 2 hours. In contrast, viable BCSCs decreased after 1 hour and then gradually increased 2.7 times compared to control after 4 hours. Conclusion: TGF-?1 treatment in low concentration and for short period of time triggers its auto-induction in BCSCs, leading to increased cell viability and stemness gene expression via autocrine signalling. © 2021 Pakistan Medical Association. All rights reserved. |
Aldehyde Dehydrogenase. (JPMA 71: S-84 [Suppl. 2]; 2021); Breast Neoplasms; Neoplastic Stem Cells; Octamer Transcription Factor-3; Transforming Growth Factor beta1 |
transforming growth factor; transforming growth factor beta; transforming growth factor beta1; breast tumor; cancer stem cell; human; Breast Neoplasms; Humans; Neoplastic Stem Cells; Transforming Growth Factor beta; Transforming Growth Factor beta1; Transforming Growth Factors |
Pakistan Medical Association |
00309982 |
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33785948 |
Conference Paper |
Q4 |
242 |
17081 |
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567 |
Damayanti R., Natsir M.P.W., Annisa I., Trianto D.M., Sungkar S., Friska D. |
57215770702;57225897287;57221960863;57222707452;57016857300;57202805330; |
Protein intake and number of children associated with nutritional status |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S99 |
S102 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103744835&partnerID=40&md5=2bb449c2ed5baffb1b8a0c1b7d2261af |
Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Damayanti, R., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Natsir, M.P.W., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Annisa, I., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Trianto, D.M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sungkar, S., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Undergradute Medical Education Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: This study aimed to evaluate the association between protein intake and number of children in a family, based on nutritional status of children aged 2 to 12 years of age. Methods: This was a cross-sectional study with consecutive sampling. Weight and height were measured, and the 24-hour food recall was gathered with a questionnaire. Nutritional status was assessed using weight-for-Age curve of Centers for Disease Control and Prevention (CDC) growth chart. Protein intake was assessed using NutriSurvey. Data were analysed with chi-square test. Results: There were 99 children, 52 girls and 47 boys. From these, 57 (57.6%) were undernourished and 42 (42.4%) subjects had a good nutritional status. Sixty-five (65.6%) children had poor protein intake, while 34 (34.3%) had adequate protein intake. There was no association between protein intake and nutritional status (p = 0.805) or number of children in the family and nutritional status (p = 0.414). The principal protein source was squid, but squid is often sold for additional income. Conclusion: The nutritional status of children in Pero Konda Village could be considered undernourished. There was no association between protein intake and number of children based on nutritional status. The villagers had poor dietary habits, so good dietary habits should be promoted. © 2021 Pakistan Medical Association. All rights reserved. |
Children; Diet; Nutritional status. (JPMA 71: S-99 [Suppl. 2]; 2021); Protein intake |
body weight; caloric intake; child; cross-sectional study; diet; feeding behavior; female; human; income; male; nutritional status; preschool child; Body Weight; Child; Child, Preschool; Cross-Sectional Studies; Diet; Energy Intake; Feeding Behavior; Female; Humans; Income; Male; Nutritional Status |
Pakistan Medical Association |
00309982 |
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33785951 |
Conference Paper |
Q4 |
242 |
17081 |
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568 |
Manggala S.K., Aditianingsih D., Harijanto E. |
57190962171;56312263600;56059081200; |
Diaphragm function in post-upper abdominal surgery: High-flow nasal cannula (HFNC) versus nasal cannula a pilot study |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S4 |
S9 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103683600&partnerID=40&md5=f3b1bfe03f068ac7f5f515249ea589e8 |
Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Manggala, S.K., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aditianingsih, D., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Harijanto, E., Department of Anesthesiology and Intensive Care, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Objective: This pilot study was performed to identify the differences between the effectiveness of HFNC and conventional oxygen therapy. Methods: This study was a part of a more extensive ongoing study in a tertiary care hospital from January to April 2019. Criteria for inclusion were adult patients scheduled for upper-Abdominal surgery. Patients were randomised into two groups: conventional oxygen therapy (n=10) and HFNC therapy (n=10). The differences in (clinical parameters;Mean Arterial Pressure (MAP), heart rate, respiratory rate), diaphragm thickening on ultrasound, air lung distribution on Electrical Impedance Tomography (EIT), and blood gas analysis data between both groups were assessed at specific times. Adverse events were recorded and treated during the study. The data collected was analysed using SPSS software version 23.0. Results: During the recuritment of patients, no issues were indentified in this study. Therefore, no clinical or statistical differences in EIT and ultrasound diaphragm thickening between the two groups were observed; no clinical or statistical differences in patterns in clinical parameters were found. The mean arterial PO2 was particulary different at time 1: 137.10 mmHg for patients in the conventional therapy group and 93.95 mmHg in the HFNC group (p = 0.001). A patient in the HFNC group reported a feeling of discomfort. Conclusion: The aim of this study was to observe differences between HFNC and conventional oxygen therapy. Nonetheless, more data are needed in order to achieve a conclusive result. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-4 [Suppl. 2]; 2021); Blood gas analysis; Electric impedance; Oxygen inhalation therapy; Tomography; Ultrasonography |
abdominal surgery; adult; arterial oxygen tension; blood gas analysis; breathing rate; computer assisted impedance tomography; conference paper; controlled study; data analysis software; diaphragm; echography; female; heart rate; high flow nasal cannula therapy; human; lung; major clinical study; male; mean arterial pressure; oxygen therapy; pilot study; randomized controlled trial; surgery; tertiary care center; cannula; diagnostic imaging; diaphragm; oxygen therapy; pilot study; respiratory failure; oxygen; Adult; Cannula; Diaphragm; Humans; Oxygen; Oxygen Inhalation Therapy; Pilot Projects; Respiratory Insufficiency |
Pakistan Medical Association |
00309982 |
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33785933 |
Conference Paper |
Q4 |
242 |
17081 |
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569 |
Kekalih A., Friska D., Nabila D., Harimurti M.E.P. |
55633562200;57202805330;57219359635;57225933113; |
Emotional readiness and weight consequences evaluation for behavioural modification of obese adolescence in jakarta-indonesia |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S46 |
S52 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103683378&partnerID=40&md5=8a3bc30c067e0ec18b7bad582e7abd0b |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kekalih, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nabila, D., Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Indonesia; Harimurti, M.E.P., Undergraduate Medical Education Program, Faculty of Medicine, Universitas Indonesia, Indonesia |
Objective: With increasing incidence of obesity in Indonesia, behavioural modification plays an important role for its management. Applying the Trans-Theoretical Model (TTM) to assess behavioural modification readiness of obese adolescence, this study highlighted two main processes of change in TTM: emotional readiness to change (EmR) and weight consequence evaluation (WCE). Adolescence may develop difference EmR and WCE in handling obesity status especially in high school and college years, due to different phases of physic, autonomy and behavioural development. Methods: A comparative cross-sectional study was conducted using validated Indonesian version of the TTM questionnaire to compare WCE and EmR scores (scale 0-100) between high school students and college freshmen group which included means comparison tests and linear regression. Results: The study involved 116 obese adolescents and majority were at the action (32%) and contemplation (31%) TTM stage. After comparing 59 high school students and 57 college freshmen, EmR and WCE scores were not significantly different (p > 0.05). Both groups had good EmR score. Weight consequences awareness were only slightly higher among college freshmen compared to high school students, scoring at 78 (20-96) and 63 (30-100) respectively. Higher body mass index was associated with better EmR and WCE scores in both groups. Conclusion: Majority of the obese adolescents were already at the action and contemplation phase and also had appropriate emotional readiness to change. However, compared to college students, high school adolescence needed more support to maintain their weight management, in the form of education to raise awareness of obesity consequences. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-46 [Suppl. 2]; 2021); Adolescent behaviors; Emotional adjustment; Obesity management |
adolescent; adolescent behavior; adolescent obesity; anthropometry; behavior change; body mass; body weight management; college student; comparative study; Conference Paper; cross-sectional study; emotional readiness; female; high school student; human; linear regression analysis; major clinical study; male; obesity management; psychological adjustment; questionnaire; transtheoretical model; weight consequence evaluation; body weight; Indonesia; obesity; Adolescent; Body Mass Index; Body Weight; Cross-Sectional Studies; Humans; Indonesia; Obesity |
Pakistan Medical Association |
00309982 |
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33785941 |
Conference Paper |
Q4 |
242 |
17081 |
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570 |
Zahrah A., Muharam R., Luky Satria Marwali M., Ocktariyana, Deraya I.E., Asmarinah |
57205418186;57191492732;57225892448;57210235127;57216313121;15820317600; |
MRNA expression and DNA methylation level of the MMP-2 gene in peritoneal endometriosis |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S112 |
S115 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103683243&partnerID=40&md5=337ed161f28b3917b291ce8b733e951a |
Master Program of Biomedical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Obstetric and Ginecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Obstetric and Ginecology, Fatmawati Central General Hospital, Jakarta, Indonesia; Department Miwifery, Politeknik Kesehatan Palembang, Ministry of Health, Indonesia; Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Zahrah, A., Master Program of Biomedical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Muharam, R., Department of Obstetric and Ginecology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Luky Satria Marwali, M., Department of Obstetric and Ginecology, Fatmawati Central General Hospital, Jakarta, Indonesia; Ocktariyana, Department Miwifery, Politeknik Kesehatan Palembang, Ministry of Health, Indonesia; Deraya, I.E., Department of Medical Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Asmarinah, Master Program of Biomedical Science, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Objective: Endometriosis is a multifactorial disease that affects 10% of women of childbearing age. Its development is known to be related to the MMP-2 gene. Specifically, the expression of MMP-2 is increase in endometriosis. The aim of this study was to evaluate the correlation between mRNA expression and DNA methylation levels of the MMP-2 gene in peritoneal endometriosis. Methods: This study used a cross-sectional design. The samples included peritoneal endometriosis tissue from women with endometriosis and normal endometrial tissue from women without endometriosis. Twenty samples of each type were taken, and the women were 20-45 years of age. Peritoneal endometriosis tissue was acquired using the laparoscopic technique, while normal endometrial tissue was taken with the microcuretase technique. The mRNA expression of the MMP-2 gene was analysed with qRT-PCR, and the level of DNA methylation of the MMP-2 gene was analysed with a methylation-specific PCR method. Results: The mRNA expression of MMP-2 gene in peritoneal endometriosis tissue was increased, and there were significant differences between peritoneal endometriosis tissue and normal endometrial tissue. The MMP-2 gene was hypermethylated, but there was no significant difference (p = 0.596) between peritoneal endometriosis tissue and endometrial tissue in terms of methylation. This study did not show a significant correlation between mRNA expression and DNA methylation levels of the MMP-2 gene (p = 0.769, r = 0.070). Conclusion: The increase in MMP-2 gene expression in peritoneal endometriosis tissue is likely not only due to hypermethylation; there are other factors that might play a role. © 2021 Pakistan Medical Association. All rights reserved. |
cytoskeleton. (JPMA 71: S-112 [Suppl. 2]; 2021); DNA methylation; endometriosis; MMP-2 |
gelatinase A; messenger RNA; cross-sectional study; DNA methylation; endometriosis; endometrium; female; genetics; human; metabolism; Cross-Sectional Studies; DNA Methylation; Endometriosis; Endometrium; Female; Humans; Matrix Metalloproteinase 2; RNA, Messenger |
Pakistan Medical Association |
00309982 |
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33785954 |
Conference Paper |
Q4 |
242 |
17081 |
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571 |
Tjahjadi R., Yusra |
57222664622;57195939842; |
Coexisting systemic lupus erythematosus and suspected hyperimmunoglobulin e syndrome: A case report |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S140 |
S142 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103682942&partnerID=40&md5=979daa2d43ac0c56ba2e276b8df67521 |
Department of Clinical Pathology, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Tjahjadi, R., Department of Clinical Pathology, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Yusra, Department of Clinical Pathology, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Hyperimmunoglobulin E syndrome (HIES) is a rare multisystem syndrome that affects musculoskeletal system, connective tissue, and immune system. Immune dysregulation in hyperimmunoglobulin E syndrome often accompanied by autoimmune diseases, such as systemic lupus erythematosus. While the role of IgG autoantibody is well known in the pathogenesis of systemic lupus erythematosus, other subtypes of autoantibodies, IgE in particular, are now known to be involved in autoimmune process. A female with known elevated IgE was diagnosed with adult onset HIES. Atypical chest pain and otherwise normal cardiac imaging studies prompted her for further lab testings. Positive antinuclear antibody immunofluorescence test and elevated anti ds-DNA led to SLE diagnosis. Lack of characteristic clinical manifestations complicates establishing HIES while showing the extent to which IgE elevation could be related to SLE. © 2021 Pakistan Medical Association. All rights reserved. |
Hyperimmunoglobulin E syndrome; IgE; Systematic lupus erythematosus. |
autoantibody; adult; autoimmune disease; case report; complication; female; human; systemic lupus erythematosus; Adult; Autoantibodies; Autoimmune Diseases; Female; Humans; Lupus Erythematosus, Systemic |
Pakistan Medical Association |
00309982 |
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33785959 |
Conference Paper |
Q4 |
242 |
17081 |
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572 |
Runtu F.M.J.G., Ardhia S.H., Lokeswara A.W., Friska D. |
57204110436;57222662640;57200937543;57202805330; |
Shaping effective communication skills in first-year medical students through community diagnosis exercise |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S37 |
S41 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103682708&partnerID=40&md5=53c2f59a400f54bb8e04b8a5a8b7140a |
Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Runtu, F.M.J.G., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Ardhia, S.H., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Lokeswara, A.W., Undergraduate Student, Faculty of Medicine, Universitas Indonesia, Indonesia; Friska, D., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: The current study aimed to evaluate the impact of students' participation in this community diagnosis (CD) exercise on their competency development. Methods: The CD was performed by 235 first-year students through a home visit to obtain health data through questionnaire and physical examination; the data was analysed using the IBM® SPSS® version 24 statistical analysis software. The impact of CD participation on student skills development was evaluated using a cross sectional questionnaire-based survey using the Likert five-point scale to assess student attitudes. Results: CD exercise was performed by 235 first-year students by collecting data from 373 community residents. Subsequently, survey on effect of CD exercise on student competency responses were collected from 47 students (20%) of the 235 CD participants; the results showed that most agreed that CD enhanced their competence as physicians in all areas. The highest mean (SD) Likert scale score was recorded for the statement, 'CD enhanced effective communication' (4.47 ±} 0.747). A total of 44 (93.6%) respondents supported the continuation of CD, claiming that the activity is a forum through which students can practice interacting with patients. Conclusion: The survey found that effective communication is the skill most established by involvement in CD, and the activity provides a good base for students' self-development as professional physicians. © 2021 Pakistan Medical Association. All rights reserved. |
(JPMA 71: S-37 [Suppl. 2]; 2021); Communication; Community; Diagnosis; Medical education |
adult; communication skill; conference paper; controlled study; exercise; female; health data; home visit; human; Likert scale; major clinical study; male; medical education; medical student; physical examination; questionnaire; resident; software; student attitude; clinical competence; interpersonal communication; Clinical Competence; Communication; Humans; Physical Examination; Students, Medical; Surveys and Questionnaires |
Pakistan Medical Association |
00309982 |
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33785939 |
Conference Paper |
Q4 |
242 |
17081 |
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573 |
Ambarsari C.G., Tambunan T., Pardede S.O., Rahman FarhanH.F., Kadaristiana A. |
57211850895;55338756200;57210394278;57215612971;57214116079; |
Role of dipstick albuminuria in progression of paediatric chronic kidney disease |
2021 |
Journal of the Pakistan Medical Association |
71 |
2 |
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S103 |
S106 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103682550&partnerID=40&md5=586bf5c6a6dfb2305e50086dc7cad5ed |
Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Ambarsari, C.G., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Tambunan, T., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pardede, S.O., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Rahman, FarhanH.F., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kadaristiana, A., Department of Child Health, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Objective: Renal function of patients with chronic kidney disease (CKD) is typically evaluated by detecting proteinuria because it is a major predictor of CKD progression. In paediatric patients with CKD, urine albumin-Tocreatinine ratio (ACR) is used to detect CKD progression, which is similar to urine protein-To-creatinine ratio (PCR). However, facilities for evaluation of urine ACR and urine PCR may not be widely available. To date, this is the first study that investigated the predictive value of baseline dipstick albuminuria for 1-year and 3-year CKD progression in Indonesian children. We assessed the association between baseline level of dipstick albuminuria and CKD progression in paediatric patients. Methods: This retrospective cohort study was conducted at the Cipto Mangunkusumo Hospital (CMH) involving 43 children with CKD between 2016 and 2019. The patients were followed up for 1 year and 3 years after enrolment. Risk ratios (RR) for 1-year and 3-year CKD progression were calculated using Fisher's exact test. Results: The RR for 1-year CKD progression in children with baseline dipstick albuminuria 2+ was 2.16 (95% CI: 1.13-4.14, p = 0.02), and the corresponding RR for 3-year CKD progression in these children was 1.70 (95% CI: 0.73-3.97, p=0.21). Conclusion: Dipstick albuminuria was not associated with 1-year and 3-year CKD progression in children. © 2021 Pakistan Medical Association. All rights reserved. |
2021); albuminuria; chronic; chronic renal insufficiency; Kidney failure; proteinuria. (JPMA 71: S-103 [Suppl. 2] |
creatinine; albuminuria; child; chronic kidney failure; disease exacerbation; glomerulus filtration rate; human; Indonesia; retrospective study; Albuminuria; Child; Creatinine; Disease Progression; Glomerular Filtration Rate; Humans; Indonesia; Renal Insufficiency, Chronic; Retrospective Studies |
Pakistan Medical Association |
00309982 |
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33785952 |
Conference Paper |
Q4 |
242 |
17081 |
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574 |
Khaedir Y., Kartika R. |
57210448725;57216548032; |
Perspectives on Targeting IL-6 as a Potential Therapeutic Strategy for COVID-19 |
2021 |
Journal of Interferon and Cytokine Research |
41 |
2 |
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37 |
43 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101400819&doi=10.1089%2fjir.2020.0135&partnerID=40&md5=98ca5a1b9e49b8a60fe141024cc36031 |
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Immunology, Master's Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Division of Metabolic, Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia |
Khaedir, Y., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia, Immunology, Master's Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Kartika, R., Division of Metabolic, Endocrinology and Diabetes, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia |
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and has been a major threat to global public health. In Indonesia, the cases have rapidly increased, and the case fatality rate remains high. With COVID-19, most of the deaths have been caused by acute respiratory distress syndrome and dysregulation of the immune response. A lung biopsy from a patient with COVID-19 showed inflammatory cellular infiltration with diffuse alveolar damage. Massive pulmonary destruction has also been reported as a result of highly increased levels of proinflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), IL-1β, interferon-γ(IFN-γ), induced protein 10 (IP-10), and monocyte chemoattractant protein-1 (MCP-1). IL-6 is an inflammatory cytokine produced by various cell types, including immune cells and nonleukocytes, such as endothelial cells, fibroblasts, epithelial cells, type II pneumocytes, and certain tumor cells. Several studies have shown that IL-6 contributes to the severity and mortality of COVID-19. In this review, we would like to explore the immune response in COVID-19 and the role of IL-6 in the immunopathogenesis of COVID-19. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
coronavirus disease 2019; immune response; interleukin-6 |
interleukin 6; tocilizumab; IL6 protein, human; interleukin 6; interleukin 6 receptor; JAK1 protein, human; JAK2 protein, human; Janus kinase 1; Janus kinase 2; Janus kinase inhibitor; monoclonal antibody; pyrazole derivative; ruxolitinib; sarilumab; tocilizumab; cell infiltration; clinical outcome; coronavirus disease 2019; cytokine storm; human; immune response; immunopathogenesis; lung alveolus cell; priority journal; prospective study; Review; Severe acute respiratory syndrome coronavirus 2; signal transduction; cytokine release syndrome; drug effect; immunology; Indonesia; pathology; respiratory distress syndrome; Antibodies, Monoclonal, Humanized; COVID-19; Cytokine Release Syndrome; Humans; Indonesia; Interleukin-6; Janus Kinase 1; Janus Kinase 2; Janus Kinase Inhibitors; Pyrazoles; |
Mary Ann Liebert Inc. |
10799907 |
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33621130 |
Review |
Q1 |
1031 |
4200 |
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575 |
Fuady A., Houweling T.A.J., Richardus J.H. |
37085331400;10639726000;7003977198; |
Perspective piece COVID-19 and tuberculosis-related catastrophic costs |
2021 |
American Journal of Tropical Medicine and Hygiene |
104 |
2 |
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436 |
440 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101400221&doi=10.4269%2fajtmh.20-1125&partnerID=40&md5=a3c370677fb6cad8407b4d92b3768798 |
Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Fuady, A., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands, Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Houweling, T.A.J., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands; Richardus, J.H., Department of Public Health, Erasmus MC, University Medical Center Rotterdam, Rotterdam, Netherlands |
The COVID-19 pandemic has created an unprecedented health crisis and a substantial socioeconomic impact. It also affects tuberculosis (TB) control severely worldwide. Interruptions of many TB control programs because of the COVID-19 pandemic could result in significant setbacks. One of the targets that can be affected is the WHO's End TB Strategy goal to eliminate catastrophic costs of TB-affected households by 2030. Disruptions to TB programs and healthcare services due to COVID-19 could potentially prolong diagnostic delays and worsen TB treatment adherence and outcomes. The economic recession caused by the pandemic could significantly impact household financial capacity because of the reduction of income and the rise in unemployment rates. All of these factors increase the risk of TB incidence and the gravity of economic impact on TB-affected households, and hamper efforts to eliminate catastrophic costs and control TB. Therefore, efforts to eliminate the incidence of TB-affected households facing catastrophic costs will be very challenging. Because financial constraint plays a significant role in TB control, the improvement of health and social protection systems is critical. Even before the pandemic, many TB-high-burden countries (HBCs) lacked robust health and social protection systems. These challenges highlight the substantial need for a more robust engagement of patients and civil society organizations and international support in addressing the consequences of COVID-19 on the control of TB. © 2021 by The American Society of Tropical Medicine and Hygiene. |
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tuberculostatic agent; clinical outcome; coronavirus disease 2019; delayed diagnosis; disaster; disease burden; disease control; economic recession; financial management; health care cost; health program; health service; household; human; incidence; income; infection control; infection risk; organization; pandemic; patient compliance; Review; social aspect; social protection system; socioeconomics; tuberculosis; unemployment; World Health Organization; economics; family size; health care cost; tuberculosis; COVID-19; Family Characteristics; Health Care Costs; Humans; Incidence; Income; SARS-CoV-2; Tuberculosis |
American Society of Tropical Medicine and Hygiene |
00029637 |
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33269683 |
Review |
Q1 |
1015 |
4298 |
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