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576 |
Elvira S.D., Lamuri A., Lukman P.R., Malik K., Shatri H., Abdullah M. |
57192888533;57222088387;55981460300;57204114533;28767986500;7103393434; |
Psychological distress among Greater Jakarta area residents during the COVID-19 pandemic and community containment |
2021 |
Heliyon |
7 |
2 |
e06289 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101376515&doi=10.1016%2fj.heliyon.2021.e06289&partnerID=40&md5=f6aaf6a6409201040c1d9b4f477052ca |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Indonesia Medical Education and Research Institute, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia |
Elvira, S.D., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Lamuri, A., Indonesia Medical Education and Research Institute, Indonesia; Lukman, P.R., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Malik, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Shatri, H., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia; Abdullah, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Indonesia |
Community quarantine; COVID-19; DASS-21; Psychological distress © 2021 The AuthorsIntroduction: Coronavirus disease 2019 (COVID-19) is an emerging pandemic affecting the global population. Community-based quarantine can slow down the pandemic growth while adversely affecting population-wide psychological well-being. Affected psychological well-being could potentially influence population compliance in following stipulated community quarantine procedures. Aim: The aim was to quantify psychological distress among Greater Jakarta area residents during the community containment period. Objectives: The objective was to measure depression, anxiety, and stress levels using the Indonesian version of the DASS-21. Demographic data on sex, education strata, and working/productive-age group were also collected. Methods: This cross-sectional observational analytic study employed an online questionnaire involving participants acquired through snowball sampling. The questionnaire comprises two parts: demographic data and psychological distress indicators. Linear regression evaluated psychological distress as a response variable. Results: Among 1,205 women and 824 men, our findings suggested male sex, age in the range of 15-24 years, and having a bachelor's degree or professional qualification have a strong association with psychological distress. Conclusion: By addressing the population at risk, policymakers can identify better countermeasures for preventing psychological distress. © 2021 The Authors |
Community quarantine; COVID-19; DASS-21; Psychological distress |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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581 |
Nugroho S.W., Perkasa S.A.H., Gunawan K., Manuhutu Y.N., Rahman M.A., Rizky A. |
57460519700;57204105609;57195935319;57221807460;57221807438;57221806899; |
Predicting outcome of hemifacial spasm after microvascular decompression with intraoperative monitoring: A systematic review |
2021 |
Heliyon |
7 |
2 |
e06115 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100277933&doi=10.1016%2fj.heliyon.2021.e06115&partnerID=40&md5=b7d2f2e7bfd453c5d93d9b6eb24a6a19 |
Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia |
Nugroho, S.W., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Perkasa, S.A.H., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Gunawan, K., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Manuhutu, Y.N., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Rahman, M.A., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Rizky, A., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia |
Hemifacial spasm, Microvascular decompression, Intraoperative monitoring, Lateral spread response, Abnormal muscle response. © 2021 The AuthorsBackground: Microvascular decompression has been established as a primary treatment for hemifacial spasm. Intraoperative monitoring is used during the surgery to guide neurosurgeons to determine whether the decompression of facial nerve from the vessel is sufficient. We performed a systematic review to assess the role of lateral spread response (LSR) monitoring in predicting hemifacial spasm outcomes after microvascular decompression. Method: A systematic search of PubMed, ScienceDirect, Cochrane, and Google Scholar was conducted. We included studies that performed microvascular decompression surgery with intraoperative monitoring analyzing the correlation between lateral spread response and spasm relief. A critical appraisal was conducted for selected studies. Result: Twenty-two studies comprising 6404 cases of hemifacial spasm, which underwent microvascular decompression surgery with intraoperative monitoring, were included. Of 15 articles that assessed symptoms shortly after surgery, 12 studies showed a significant correlation between lateral spread response resolution and disappearance of spasm. Four of six studies that evaluated the outcome at 3-month follow-up showed significant relationship between LSR and outcome, so did five of six articles that assessed spasm relief at 6-month follow-up. As much as 62.5% of studies (10 of 16) showed the result at long-term follow-up (≥1-year) was not significant. Conclusion: Intraoperative monitoring during microvascular decompression surgery can be a useful tool to predict hemifacial spasm resolution. Though long-term outcomes of patients with LSR relief and persistence are similar, resolution of symptoms shortly after surgery will provide comfort to patients thereby improving their quality of life. © 2021 The Authors |
Abnormal muscle response; Hemifacial spasm; Intraoperative monitoring; Lateral spread response; Microvascular decompression |
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Elsevier Ltd |
24058440 |
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Review |
Q1 |
455 |
10919 |
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592 |
Pribadi R.R., Simadibrata M. |
57194732282;23499598400; |
Increased serum amylase and/or lipase in coronavirus disease 2019 (COVID-19) patients: Is it really pancreatic injury? |
2021 |
JGH Open |
5 |
2 |
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190 |
192 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098140408&doi=10.1002%2fjgh3.12436&partnerID=40&md5=14da866c743f8e6c2bdfff73d45cc7a5 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Pribadi, R.R., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Coronavirus disease 2019 (COVID-19) is a novel disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although it mainly affects the respiratory system, the pancreas could also become the virus' target. The issue regarding pancreatic involvement in COVID-19 has been raised by several researchers. They found increased serum amylase and/or lipase in COVID-19 patients, which suggested pancreatic injury. We aimed to critically review the evidence to provide insights and to answer the very question of the possibility of pancreatic injury. Current evidence shows that increased amylase and/or lipase is not necessarily a pancreatic injury in COVID-19 patients. Those increased enzymes might also be found in other clinical conditions. © 2020 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
amylases; COVID-19; lipase; pancreas |
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John Wiley and Sons Inc |
23979070 |
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Review |
Q3 |
546 |
9258 |
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594 |
Marwali E.M., Caesa P., Rayhan M., Roebiono P.S., Fakhri D., Haas N.A., Kajimoto M., Portman M.A. |
36608535400;57204921746;57219904946;57192895321;8599513100;7103216848;56202804200;7004985824; |
The effect of oral triiodothyronine supplementation on lactate and pyruvate after paediatric cardiac surgery |
2021 |
Cardiology in the Young |
31 |
2 |
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205 |
211 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095997599&doi=10.1017%2fS1047951120003698&partnerID=40&md5=ec7d88033ff87cad7cdbbc609d229529 |
Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Department of Cardiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiovascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Department of Pediatrics, University of Washington School of Medicine and Division of Cardiology, Seattle Children's Hospital, Seattle, WA, United States |
Marwali, E.M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Caesa, P., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Rayhan, M., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia; Roebiono, P.S., Pediatric Cardiac Intensive Care Division, National Cardiovascular Center Harapan Kita, Jl. Let. Jend. S. Parman Kav. 87, Jakarta, 11420, Indonesia, Department of Cardiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fakhri, D., Department of Thoracic Cardiovascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haas, N.A., Department of Pediatric Cardiology and Pediatric Intensive Care, Medical Hospital of the University of Munich, Munich, Germany; Kajimoto, M., Department of Pediatrics, University of Washington School of Medicine and Division of Cardiology, Seattle Children's Hospital, Seattle, WA, United States; Portman, M.A., Department of Pediatrics, University of Washington School of Medicine and Division of Cardiology, Seattle Children's Hospital, Seattle, WA, United States |
Abstract Objective: To determine if triiodothyronine alters lactate, glucose, and pyruvate metabolism, and if serum pyruvate concentration could serve as a predictor of low cardiac output syndrome in children after cardiopulmonary bypass procedures. Methods: This study was ancillary to the Oral Triiodothyronine for Infants and Children undergoing Cardiopulmonary bypass (OTICC) trial. Serum pyruvate was measured in the first 48 patients and lactate and glucose were measured in all 208 patients enrolled in the OTICC study on the induction of anaesthesia, 1 and 24 hours post-aortic cross-clamp removal. Patients were also defined as having low cardiac output syndrome according to the OTICC trial protocol. Result: Amongst the designated patient population for pyruvate analysis, 22 received placebo, and 26 received triiodothyronine (T3). Lactate concentrations were nearly 20 times greater than pyruvate. Lactate and pyruvate levels were not significantly different between T3 and placebo group. Glucose levels were significantly higher in the placebo group mainly at 24-hour post-cross-clamp removal. Additionally, lactate and glucose levels peaked at 1-hour post-cross-clamp removal in low cardiac output syndrome and non-low cardiac output syndrome patients, but subsequently decreased at a slower rate in low cardiac output syndrome. Lactate and pyruvate concentrations correlated with glucose only prior to surgery. Conclusion: Thyroid supplementation does not alter systemic lactate/pyruvate metabolism after cardiopulmonary bypass and reperfusion. Pyruvate levels are not useful for predicting low cardiac output syndrome. Increased blood glucose may be regarded as a response to hypermetabolic stress, seen mostly in patients with low cardiac output syndrome. © 2021 Cambridge University Press. All rights reserved. |
cardiopulmonary bypass; congenital heart disease; euthyroid sick syndrome; Keywords: Lactate; low cardiac output syndrome; pyruvate; thyroid hormone replacement |
glucose; lactic acid; liothyronine; placebo; pyruvic acid; aortic clamping; Article; cardiopulmonary bypass; child; childhood; clinical article; female; forward heart failure; glucose blood level; heart muscle reperfusion; heart surgery; human; infant; lactate blood level; male; metabolism |
Cambridge University Press |
10479511 |
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33168128 |
Article |
Q3 |
386 |
12454 |
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596 |
Dilogo I.H., Rahmatika D., Pawitan J.A., Liem I.K., Kurniawati T., Kispa T., Mujadid F. |
56161962800;57474077600;6508348067;55802927800;55213290600;56515348000;57204398571; |
Allogeneic umbilical cord-derived mesenchymal stem cells for treating critical-sized bone defects: a translational study |
2021 |
European Journal of Orthopaedic Surgery and Traumatology |
31 |
2 |
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265 |
273 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089486454&doi=10.1007%2fs00590-020-02765-5&partnerID=40&md5=617ce3dfaeed87e7c027f5f3006ebb43 |
Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia; Department Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, Jakarta, Indonesia; Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, Jakarta, Indonesia |
Dilogo, I.H., Department of Orthopaedic and Traumatology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia, Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmatika, D., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia; Pawitan, J.A., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia, Department Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, Jakarta, Indonesia, Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Liem, I.K., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia, Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jl. Salemba 6, Jakarta, Indonesia; Kurniawati, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia, Stem Cell and Tissue Engineering Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kispa, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia; Mujadid, F., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, CMU 2 Building 5th Floor, Jl. Diponegoro 71, Jakarta Pusat, Indonesia |
Introduction: The current ‘gold-standard’ treatment of critical-sized bone defects (CSBDs) is autografts; however, they have drawbacks including lack of massive bone source donor site morbidity, incomplete remodeling, and the risk of infection. One potential treatment for treating CSBDs is bone marrow-derived mesenchymal stem cells (BM-MSCs). Previously, there were no studies regarding the use of human umbilical cord-mesenchymal stem cells (hUC-MSCs) for treating BDs. We aim to investigate the use of allogeneic hUC-MSCs for treating CSBDs. Method: We included subjects who were diagnosed with non-union fracture with CSBDs who agreed to undergo hUC-MSCs implantation. All patients were given allogeneic hUC-MSCs. All MSCs were obtained and cultured using the multiple-harvest explant method. Subjects were evaluated functionally using the Lower Extremity Functional Scale (LEFS) and radiologically by volume defect reduction. Result: A total of seven (3 male, 4 female) subjects were recruited for this study. The subjects age ranged from 14 to 62 years. All seven subjects had increased LEFS during the end of the follow-up period, indicating improved functional ability. The follow-up period ranged from 12 to 36 months. One subject had wound dehiscence and infection, and two subjects developed partial union. Conclusion: Umbilical cord mesenchymal stem cells are a potential new treatment for CSBDs. Additional studies with larger samples and control groups are required to further investigate the safety and efficacy of umbilical cord-derived mesenchymal stem cells for treating CSBDs. © 2020, Springer-Verlag France SAS, part of Springer Nature. |
Critical-sized bone defect; Mesenchymal stem cells; Umbilical cord |
adolescent; adult; allotransplantation; Article; bone defect; clinical article; clinical outcome; critical sized bone defect; female; follow up; fracture nonunion; functional status; human; human cell; Lower Extremity Functional Scale; male; mesenchymal stem cell transplantation; middle aged; priority journal; surgical infection; time to treatment; umbilical cord mesenchymal stem cell; wound dehiscence; young adult; autotransplantation; cell culture; cell differentiation; hematopoietic stem cell transplantation; mesenchymal stem cell; mesenchymal stem cell transplantation; umbilical cord; Adolescent; Adult; Cell Differentiation; Cells, Cultured; Female; Hematopoietic Stem Cell Transplantation; Humans; Male; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Middle Aged; Transpl |
Springer-Verlag Italia s.r.l. |
16338065 |
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32804289 |
Article |
Q1 |
851 |
5541 |
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648 |
Sungkar A. |
55110453800; |
Preterm birth in low-resource setting |
2021 |
Donald School Journal of Ultrasound in Obstetrics and Gynecology |
15 |
2 |
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175 |
178 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121540929&doi=10.5005%2fjp-journals-10009-1695&partnerID=40&md5=6bdfb4b0abc69737097e5332647cdcc6 |
Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Sungkar, A., Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Preterm labor (PTL) is a global problem which is a complex disease with a high rate of morbidity and mortality, also has long-term consequences for the baby and the family. The well-known morbidities related to PTL are respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, and anemia of prematurity. In a developing country, the management of PTL is limited by poor health systems, low education level of the mother, poor financial support, lack of facility and trained health personnel, and demographic barriers. This limitation leads to high morbidity and mortality of preterm birth, especially in developing countries. It is important to reduce the rate of preterm birth by preventing the event. Several risk factors have been identified and are avoidable and preventable, such as smoking, bacterial infection, poor nutritional status, and malnourished mothers. Strategies to prevent PTL have been proposed in primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. © Jaypee Brothers Medical Publishers. 2021. |
Management; Morbidity and mortality; Preterm labor; Risk factor |
fibronectin; folic acid; homocysteine; iron; trace element; zinc; allergy; body mass; cigarette smoking; early diagnosis; endocrine disease; gestational weight gain; graft rejection; human; hyperhomocysteinemia; hypertension; infertility therapy; intrauterine growth retardation; intrauterine infection; ischemia; macronutrient; morbidity; mortality; multiple pregnancy; non communicable disease; nutritional deficiency; preeclampsia; pregnancy diabetes mellitus; premature labor; prepregnancy care; Review; risk factor; transvaginal echography; uterine cervix carcinoma in situ; uterine cervix incompetence; vascular disease |
Jaypee Brothers Medical Publishers (P) Ltd |
0973614X |
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Review |
Q4 |
162 |
22036 |
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723 |
Rohsiswatmo R., Widodo A.D., Munasir Z., Medise B.E. |
55533574600;57117722400;7801694370;57226215370; |
Prebiotic supplementation supports immunity & growth-development in preterm infants: A review and expert perspectives |
2021 |
Bali Medical Journal |
10 |
2 |
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785 |
792 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114340415&doi=10.15562%2fbmj.v10i2.2490&partnerID=40&md5=cffe54e9756788dc9eeb8ca22d1e3c5a |
Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Harapan Kita National Center for Woman and Child Health Care, Jakarta, Indonesia |
Rohsiswatmo, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widodo, A.D., Harapan Kita National Center for Woman and Child Health Care, Jakarta, Indonesia; Munasir, Z., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Medise, B.E., Department of Child Health, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Preterm birth still causes significant mortality and morbidity in newborns, despite modern advancements in preterm care. The gut microbiota is the most significant microbial colonization in the human body and plays a significant role in supporting a healthy body. Preterm infants are susceptible to gut dysbiosis, which is thought to contribute to the many adverse outcomes of prematurity, such as necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and developmental delays. Human breast milk is considered the ideal nutrition source for newborns and can help create ideal microbiota in preterm infants. Breast milk contains human milk oligosaccharides (HMO), prebiotics that promote beneficial bacteria growth, absent in cow’s milk. Supplementation of non-milk oligosaccharides such as long-chain fructo-oligosaccharides (lcFOS) and small-chain galacto-oligosaccharides (scGOS) in formula milk for preterm infants is found to be beneficial with a favourable safety profile. This review discusses gut microbiota in preterm neonates, its role in developing immune systems, growth and development, and the benefits of prebiotic supplementation. © 2021, Sanglah General Hospital. All rights reserved. |
Development; Growth; Immunity; Prebiotic; Prematurity; Preterm birth |
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Sanglah General Hospital |
20891180 |
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Review |
#N/A |
#N/A |
#N/A |
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737 |
Cheah F.-C., Tan T.-L., Herulah U., Dilantika C., Muhardi L., Deshpande G., Rohsiswatmo R., Saluja S., Van Elburg R. |
6603939153;57221865957;56682082100;35490282300;57216729101;16432470300;55533574600;57206226525;7004570423; |
Recommendations to promote breast milk feeding and enhance nutritional care for preterm infants in the Asia-Pacific region: Highlights from a roundtable discussion of key opinion leaders |
2021 |
Malaysian Journal of Nutrition |
27 |
2 |
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201 |
207 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112264614&doi=10.31246%2fMJN-2020-0124&partnerID=40&md5=6c8041236a4fe926cd7bde67a5a705d9 |
Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia; Danone Nutricia Early Life Nutrition, Sydney, Australia; Danone Nutricia Early Life Nutrition, Jakarta, Indonesia; Nepean Hospital, Sydney, Sydney Medical School Nepean, University of Sydney, Australia; Division of Perinatology, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Neonatology Department, Sir Ganga Ram Hospital, New Delhi, India; Department of Pediatrics, Emma Children’s Hospital Amsterdam University Medical Center, Amsterdam, Netherlands |
Cheah, F.-C., Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia; Tan, T.-L., Department of Paediatrics, Universiti Kebangsaan Malaysia Medical Centre, Kuala Lumpur, Malaysia; Herulah, U., Danone Nutricia Early Life Nutrition, Sydney, Australia; Dilantika, C., Danone Nutricia Early Life Nutrition, Jakarta, Indonesia; Muhardi, L., Danone Nutricia Early Life Nutrition, Jakarta, Indonesia; Deshpande, G., Nepean Hospital, Sydney, Sydney Medical School Nepean, University of Sydney, Australia; Rohsiswatmo, R., Division of Perinatology, Department of Pediatrics, Faculty of Medicine, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Saluja, S., Neonatology Department, Sir Ganga Ram Hospital, New Delhi, India; Van Elburg, R., Department of Pediatrics, Emma Children’s Hospital Amsterdam University Medical Center, Amsterdam, Netherlands |
Introduction: Preterm infants are vulnerable to nutritional deficiencies, thus optimal nutrition is crucial in promoting growth among these infants. However, socio-cultural complexities and limited resources in the Asia-Pacific demands a judicious approach in implementing nutritional care that is pragmatic to align with current evidence-based recommendations. Methods: A roundtable meeting was held in Jakarta in 2017 for key opinion leaders in neonatology from the Asia- Pacific to discuss issues when delivering nutritional care in this region and the unique circumstances encountered. Results: Priority areas discussed include: (i) breast milk feeding, (ii) donor milk bank/sharing, (iii) human milk fortification, and (iv) nutrient-enriched breast milk substitutes. Socio-cultural practices impeding breastfeeding, insufficient maternity leave, the religious issue of milk kinship, and limited availability of specialty nutritional care products were among the most challenging factors. Conclusion: The group proposed recommendations to enhance breastfeeding uptake, accessibility to a complete portfolio of specialty nutritional care products, and encouraging more active collaborations to engage policy makers in addressing these contemporary issues. © 2021 |
Breastfeeding; donor human milk; human milk fortifier; milk kinship; preterm infant |
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Malaysian Journal of Nutrition |
1394035X |
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Short Survey |
Q4 |
192 |
19873 |
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743 |
Soeroso N.N., Ananda F.R., Pradana A., Tarigan S.P., Syahruddin E., Noor D.R. |
57201670271;57201666959;57202578193;6602815057;6507688750;57214096801; |
The absence of mutations in the exon 2 kras gene in several ethnic groups in north sumatra may not the main factor for lung cancer |
2021 |
Acta Informatica Medica |
29 |
2 |
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108 |
112 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111477707&doi=10.5455%2fAIM.2021.29.108-112&partnerID=40&md5=4854ca99a072394cbd039b5f66172820 |
Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia |
Soeroso, N.N., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Ananda, F.R., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Pradana, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Tarigan, S.P., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Syahruddin, E., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia |
Background: Rat Sarcoma (RAS) protein encoded Guanosine Triphosphate (GTP-ase) activity, known as a switch of cell proliferation. The mutation of this protein alters the early stage of carcinogenesis and along with the interaction with other oncogene drivers and environmental factors affect the clinical characteristics and prognosis in cancer patients, particularly lung cancer. Objective: This study aims to determine the Kristen Rat Sarcoma (KRAS) mutation in lung cancer patients in North Sumatera and evaluate factors that might contribute in the development of lung cancer in the absence of KRAS mutation. Methods: This was a retrospective cohort study enrolled 44 subjects age > 18 year with the diagnosis of lung cancer. Histopathology preparation was obtained from surgery, bronchoscopy, and percutaneus needle biopsy then formed as paraffin-block. KRAS mutation was analyzed using Polymerase Chain Reaction (PCR) method with specific primer of exon 2 for evaluating the expression of RAS protein then continued with Sanger Sequencing Method at 12th and 13th codon. Results: The majority of subjects were male, age > 40 years old, bataknese, heavy smoker, with Adenocarcinoma. Almost all the subjects showed the expression of exon 2 of RAS protein in PCR examinations. However, Sequencing analysis using Bioedit Software, BLASTs and Finch T showed GGT GGC as protein base 219-224 which represented 12th and 13th Codon 12 and 13. The results interpreted there was no mutations of exon 2 of KRAS in North Sumatera Population. Conclusion: The absence of KRAS mutation in exon 2 in several ethnics in North Sumatera populations was not the main factors of lung cancer. © 2021 Noni Novisari Soeroso, Fannie Rizki Ananda, Andika Pradana, Setia Putra Tarigan, Elisna Syahruddin, Dimas Ramadhian Noor |
Ethnic variation; Exon 2; Indonesian; KRAS mutation; Lung cancer |
K ras protein; adult; age; Article; bronchoscopy; cancer diagnosis; cancer patient; cancer surgery; clinical article; cohort analysis; controlled study; ethnic difference; female; gender; gene expression; gene mutation; histopathology; human; lung adenocarcinoma; lung cancer; male; needle biopsy; polymerase chain reaction; retrospective study; Sanger sequencing; smoking |
Avicena Publishing |
03538109 |
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Article |
Q3 |
267 |
15980 |
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745 |
Syam A.F. |
8443384400; |
Gastrointestinal disorders in covid-19 patients: A great imitator |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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166 |
169 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111112690&doi=10.13181%2fmji.bc.204960&partnerID=40&md5=1e55d25030cd22add972a3dac84c5ac5 |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Syam, A.F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Up to this point, the coronavirus disease 2019 (COVID-19) pandemic is still ongoing. Some studies with a large number of cases have reported its clinical manifestations, concluding that the disease is a great imitator. Patients may present with symptoms other than the main symptoms of respiratory tract infections, such as diarrhea, abdominal pain, nausea, or vomiting, which may sometimes cause a delayed treatment in managing COVID-19 patients. Reports of various hospitals have also demonstrated gastrointestinal complaints as a clinical manifestation in those patients. The patients may come with gastrointestinal symptoms as their early clinical manifestation, or the gastrointestinal symptoms may be found in hospitalized COVID-19 patients, which indeed can be explained since the SARS-CoV-2, an etiologic agent of COVID-19 infection, can obviously be found along the gastrointestinal tract. Hence, the virus can be found in fecal and anal, and therefore, rectal swabs can be used as a diagnostic tool for COVID-19 infection. © 2021 Author. |
COVID-19; Gastrointestinal disease; SARS-CoV-2 |
alkaline phosphatase; angiotensin converting enzyme 2; aspartate aminotransferase; transmembrane protease serine 2; virus RNA; anal swab; Article; coronavirus disease 2019; coughing; diabetes mellitus; diarrhea; dyspnea; epigastric pain; feces analysis; fever; gastrointestinal disease; gastrointestinal symptom; gastrointestinal tract; human; hypertension; inflammatory bowel disease; lung lavage; nasopharyngeal swab; nausea and vomiting; nonhuman; pneumonia; real time reverse transcription polymerase chain reaction; rectal swab; RNA virus; Severe acute respiratory syndrome coronavirus 2; stomach pain; thorax radiography; virus transmission |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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