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776 |
Liem I.K., Oktavina R., Zakiyah, Anggraini D., Deraya I.E., Kodariah R., Krisnuhoni E., Wuyung P.E. |
55802927800;57224993301;57224999441;57225000673;57216313121;14010667100;35310982200;57192889605; |
Intravenous injection of umbilical cord-derived mesenchymal stem cells improved regeneration of rat liver after 2aaf/ccl4-induced injury |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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317 |
326 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108885347&doi=10.3844%2fojbsci.2021.317.326&partnerID=40&md5=e4defc3d20063b1647d2241805bc3694 |
Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Liem, I.K., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Integrated Laboratory, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavina, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine and Health Science, Universitas Kristen Krida Wacana, Jakarta, Indonesia; Zakiyah, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Yarsi, Jakarta, Indonesia; Anggraini, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell and Tissue Engineering Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Deraya, I.E., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodariah, R., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Krisnuhoni, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The effectivity of Mesenchymal Stem Cell (MSC) therapy for chronic liver injury is still questioned due to its possibility to have a pro-fibrotic effects. Other consideration is the preferably peripheral Intravenous (IV) route of application rather than direct to the target organ, such as portal vein or splenic vein, since the most of MSC will be trapped in the lung and other organs. Therefore, a study has been carried out in an animal model of chronic liver injury, 2AAF/CCl4 rats, to find out whether IV injection of single dose, 1×106 human umbilical cord-derived MSC (hUC-MSC) can regenerate the liver tissue and reduce the fibrosis. Male Wistar rats (n = 18, 8 weeks, 160-200 g) were divided into three groups of six rats, i.e., group I (control/healthy rats), group II (2AAF/CCl4-induced liver injury with hUC-MSC injected rats) and group III (2AAF/CCl4-incuded liver injury without hUC-MSC injected rats). Gross anatomical features of the livers and blood examination were tested. There was no significant different of the Alanine Aminotransferase (ALT) and Albumin serum level between groups; however there was a tendency of ALT decrease and Albumin increase in stem cells treated rats (group II). Histopathological observation using hematoxylin eosin and Masson’s trichrome staining showed an improvement in the liver damage condition (reduction of necrosis and coverage area of fat degeneration) and an improvement in the fibrosis condition in the group II compared to the group III. None of group II rat had fallen into cirrhosis as seen in group III. Immunohistochemistry staining against Caspase 3 (biomarker for apoptosis) also showed significant reduction (p = 0.038; Tukey multiple comparison test) of group II expression index (2.74%) compared to the group III (8.64%). In conclusion, IV injection of single dose, 1×106 hUC-MSC could regenerate the liver tissue and reduce the fibrosis in 2AAF/CCl4 rats model of chronic liver injury. © 2021 Isabella Kurnia Liem, Reni Oktavina, Zakiyah, Dian Anggraini, Irwina Eka Deraya, Ria Kodariah, Ening Krisnuhoni, and Puspita Eka Wuyung. |
2AAF/CCl4; Caspase 3; Liver Fibrosis; Liver Injury; Liver Regeneration; MSC |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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779 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Reksodiputro M.H. |
57223447932;15055173800;56039633100;36520254800;8678136400;12777341300;56275255400;57016857300;6507225348;21933841000;35090488800; |
Advance-Platelet Rich Fibrin and Hyaluronic Acid Combination Improves Interleukin-6 and Granulation Index in Diabetic Foot Ulcer Patients |
2021 |
Indonesian Biomedical Journal |
13 |
2 |
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170 |
177 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108646812&doi=10.18585%2finabj.v13i2.1501&partnerID=40&md5=38a4d6d4cd5994b04badcabc1939a76e |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jl. Arjuna Utara No.6, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, Indonesia |
BACKGROUND: Diabetic foot ulcer (DFU) is the most common and threatening complication of Diabetes Mellitus (DM). Ideal wound dressing for DFU management should relieve symptoms, provide wound protection, and encourage healing. Advanced-Platelet Rich Fibrin (A-PRF) and Hyaluronic Acid (HA) have been proven to improve wound healing process. This study was aimed to demonstrate the ability of combination of A-PRF and HA in reducing inflammation and improving DFU tissue healing. METHODS: Twenty DFU subjects were involved in this study, and divided into two groups based on the topical fibrin gel treatment: A-PRF + HA group and A-PRF only group. A-PRF was obtained by peripheral blood centrifugation. A-PRF + HA was prepared by homogening A-PRF and AH with a ratio of 1:0.6. Interleukin-6 (IL-6) level, granulation index (GI), numeric pain score (NPS), and inflammation clinical symptoms (ICS) were assessed on day-0, 3, 7 and 14. RESULTS: Wound swabs' IL-6 level on day-7 was found to be significantly lower in A-PRF + HA compared to A-PRF alone (p=0.041). The IL-6 level reduction also found to be significant higher either in wound swabs (day 0-7, p=0.015) or fibrin gel (day 0-3, p=0.049; day 0-7, p=0.034). A-PRF + HA treatment significantly increased the GI even since day-3 (p=0.043), with lower NPS (p<0.001), and ICS score. CONCLUSION: The combination of A-PRF and HA increases the GI in DFU healing by reducing the inflammation state which will induce the angiogenesis process, as well as reducing pain in DFU subjects better than A-PRF alone. © 2021. All Rights Reserved. |
angiogenesis; inflammation; interleukin-6; proliferation; wound healing |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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780 |
Giantini A., Timan I.S., Listiyaningsih E., Dharma R., Setiabudy R., Alwi I., Partakusuma L.G., Indrasari N.D., Harahap· A.R., Suparmin· S., Sahar W., Sukmawan R. |
12776781400;6602793366;57224237184;12777817700;6602316235;15055173800;57224924047;6506289872;57224930255;57218100688;57224929934;8651025300; |
Comparison of Light Transmission Aggregometry and VerifyNow in Detecting Clopidogrel Resistance and Factors Affecting Clopidogrel Resistance in AMI-EST Patients Undergoing Percutaneous Coronary Intervention: A Cross-Sectional Study |
2021 |
Indonesian Biomedical Journal |
13 |
2 |
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163 |
169 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108601516&doi=10.18585%2finabj.v13i2.1477&partnerID=40&md5=2ade19315f56303e4e2ab7f2428ec652 |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia |
Giantini, A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Timan, I.S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Listiyaningsih, E., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Dharma, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Setiabudy, R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Alwi, I., Department of Internal Medicine, Cardiology Division, Metropolitan Medical Centre (MMC) Hospital, Jl. H.R. Rasuna Said Kav. C-21, Jakarta, Indonesia; Partakusuma, L.G., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Indrasari, N.D., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Department of Clinical Pathology, Cipto Mangunkusumo National Central General Hospital, Jl. Pangeran Diponegoro No.71, Jakarta, Indonesia; Harahap·, A.R., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia, Eijkman Institute, Jl. Pangeran Diponegoro No. 69, Jakarta, Indonesia; Suparmin·, S., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No.6, Jakarta, Indonesia; Sahar, W., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia; Sukmawan, R., Harapan Kita Heart and Vascular Hospital, Jl. Letjen S. Parman Kav.87, Jakarta, Indonesia |
BACKGROUND: Light transmission aggregometry (LTA) and VerifyNow is commonly used to measure platelet responsiveness to clopidogrel. This study aimed to compare the results of LTA and VerifyNow P2Y12 assay for assessing the clopidogrel resistance in patients undergoing percutaneous coronary intervention and determine factors affecting clopidogrel resistance. METHODS: The subjects were 119 patients who underwent percutaneous coronary intervention (PCI) and had given loading dose of 600 mg clopidogrel. Blood samples were taken at 6 hour after clopidogrel loading dose. Platelet aggregation was measured by LTA and Verify Now. RESULTS: LTA and VerifyNow assay showed fair agreement with Kappa=0.270, p=0.001. The proportion of resistance to clopidogrel using VerifyNow was 21.8% and LTA was 47.1%. Patients with diabetes melitus were more likely to develop clopidogrel resistance than patients without diabetes (OR of 7.67; 95% CI: 1.87-31.50; p=0.005). CONCLUSION: The ability of LTA and VerifyNow in detecting clopidogrel resistance were not comparable. Multivariate analysis results for VerifyNow shows diabetes mellitus as the greatest predictors of clopidogrel resistance. © 2021. All Rights Reserved. |
agreement; clopidogrel resistance; LTA; predictor; VerifyNow |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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786 |
Sahar N., Birowo P., Thuffi R., Muharram A.R., Ode Z.W., Subahar R., Yazid F., Handayani S.I., Prasasty V.D. |
57212464367;6504153311;57212475033;57224640920;57222324817;57224626083;57207890516;57207819540;56019989700; |
Fsh receptor and ki-67 protein expressions of endometrial macaque in mid-luteal phase after exposure to various doses of recombinant fsh and fixed-dose of gnrh agonist |
2021 |
OnLine Journal of Biological Sciences |
21 |
2 |
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260 |
266 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108083891&doi=10.3844%2fojbsci.2021.260.266&partnerID=40&md5=6752f9329d0eda8fbfaee279007348a8 |
Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
Sahar, N., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Departement of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Thuffi, R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muharram, A.R., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ode, Z.W., Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Subahar, R., Departemen of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Handayani, S.I., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prasasty, V.D., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia |
There are many advances in Assisted Reproductive Technologies (ARTs). However, implantation rates are still low. The embryo implantation is a mutual interaction between the blastocyst and endometrium. This study aimed to investigate the endometrial cell proliferation stimulated by recombinant Follicle-Stimulating Hormone (rFSH) in various doses by looking at FSH-Receptor (FSHR) and Ki-67 protein expressions. The studied samples were Stored Biological Materials (SBMs) from the endometrial tissue of Macaca nemestrina. All sample was obtained from fifteen macaques, divided into four groups, which three groups were treated with rFSH and given fixed-dose (160 µg/day) of Gonadotropin-Releasing Hormone (GnRH) agonists and one control group as normal group. The three treated macaque groups were stimulated with 30, 50 and 70 IU doses of rFSH. There was no significant difference in various doses of rFSH towards FSHR and Ki-67 expressions in endometrial tissue of M. nemestrina. Therefore, this result did not significantly correlate FSHR and Ki-67 expressions in the endometrial tissue of M. nemestrina after rFSH administration. Moreover, the highest rFSH dose did not reduce the FSHR and Ki-67 expressions and there was no correlation between FSHR and Ki-67 expressions. It can be concluded that macaque endometrial cells were receptive to the given dosages of rFSH. © 2021 Nurhuda Sahar, Ponco Birowo, Rosalina Thuffi andhea Raden Muharram, Zulhulaifah Wa Ode, Rijal Subahar, Fatmawaty Yazid, Supri Irianti Handayani and Vivitri Dewi Prasasty. |
Endometrial Tissue; FSHR; Macaque; Proliferation Marker; RFSH |
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Science Publications |
16084217 |
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Article |
Q4 |
152 |
23000 |
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795 |
Nadhif M.H., Irsyad M., Utomo M.S., Suhaeri M., Whulanza Y. |
57189057498;57220935587;56180933900;56183087500;36807053500; |
Computational Analysis of Soft Polymer Lattices for 3D Wound Dressing Materials |
2021 |
Journal of Mechanical Engineering |
18 |
2 |
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1 |
11 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107456696&partnerID=40&md5=fb3bc81a587f3564de3a190ebd6e1a72 |
Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia; Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia; Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Irsyad, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Utomo, M.S., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia; Suhaeri, M., Medical Technology Cluster, Indonesia Medical Education and Research Institute (IMERI), Indonesia, Research Center for Metallurgy and Material, Indonesia Institute of Science (LIPI), Indonesia, Indonesia Unit of Education, Research and Training, Universitas Indonesia Hospital, Universitas Indonesia, Indonesia; Whulanza, Y., Department of Mechanical Engineering, Faculty of Engineering Universitas, Indonesia, Research Center on Biomedical Engineering (RCBE), Faculty of Engineering Universitas, Indonesia |
One of the wound treatments was negative pressure wound therapy (NPWT), which used wound dressings on the wound bed to ameliorate the wound healing. Unfortunately, most wound dressings were two dimensional (2D), lacking the ability to cover severe wounds with a straightforward procedure. The sheets needed to be stacked following the wound curvature, which might be problematic since improper stacking could hinder the wound healing. Regarding the mentioned problems, our group develop 3D wound dressings, which are made using 3D printers. The wound dressings are made of polycaprolactone (PCL), polyurethane (PU), and polyvinyl alcohol (PVA). As the initial stage, the mechanical integrity of the soft polymers was investigated under uniaxial tensile and uniaxial compressive stress using computational methods. The polymers were defined as 3D lattices following the dimension of existing wound dressings. Based on the simulation results of displacement and von Mises stress, the three polymers are mechanically safe to be used as wound dressing materials. © 2021 College of Engineering, Universiti Teknologi MARA (UiTM), Malaysia. All Rights Reserved. |
Computational analysis; Lattice; Soft polymer; Wound dressing |
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UiTM Press |
18235514 |
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Article |
Q3 |
216 |
18402 |
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807 |
Jusman S.W.A., Azzizah I.N., Sadikin M., Hardiany N.S. |
36518792100;57223677370;57205093115;57192910605; |
Is the mitochondrial function of keloid fibroblasts affected by cytoglobin? |
2021 |
Malaysian Journal of Medical Sciences |
28 |
2 |
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39 |
47 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106010069&doi=10.21315%2fmjms2021.28.2.4&partnerID=40&md5=8c4df0a7d2cdcd87611b189bf2440f21 |
Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Indonesia; Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Jusman, S.W.A., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Azzizah, I.N., Faculty of Medicine Universitas Indonesia, Indonesia; Sadikin, M., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: A keloid is a benign skin tumour characterised by excessive proliferation of fibroblasts, a process that requires a sufficient amount of energy. The energy needs are associated with adequate oxygen (O2) flow and well-functioning mitochondria. It is known that cytoglobin (CYGB) has a function in O2 distribution. The aim of the present study was to explore whether the inhibition of CYGB expression caused impaired mitochondrial function of keloid fibroblasts. Methods: An in vitro study was conducted on a keloid fibroblast derived from our previous study. The study was carried out in the laboratory of the Biochemistry & Molecular Biology Department, Faculty of Medicine, Universitas Indonesia (FMUI), from July to December 2018. CYGB expression was inhibited by small interfering ribonucleic acid (siRNA) and CYGB. Analysis of mitochondrial function was observed through peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a mitochondrial biogenesis marker and the activity of the succinate dehydrogenase (SDH) enzyme in mitochondria. Results: The CYGB gene and protein were downregulated after treatment with CYGB siRNA. Inhibition of CYGB expression with siRNA also tended to decrease the levels of PGC-1α messenger ribonucleic acid (mRNA) and protein, as well as SDH enzyme activity. Conclusion: Inhibition of CYGB expression with siRNA tended to decrease mitochondrial biogenesis and function. This may be useful for understanding the excessive proliferation of fibroblasts in keloids and for development of treatment for keloids. © Penerbit Universiti Sains Malaysia, 2021. |
CYGB siRNA; Keloid fibroblasts; PGC-1α; SDH enzyme activity |
cytoglobin; oxygen; peroxisome proliferator activated receptor gamma coactivator 1alpha; small interfering RNA; succinate dehydrogenase; Article; cell function; cell proliferation; colorimetry; controlled study; down regulation; enzyme activity; enzyme linked immunosorbent assay; fibroblast; gene expression; genetic transfection; human; human cell; in vitro study; keloid; mitochondrial biogenesis; mitochondrial genetics; mRNA expression level; protein expression; protein isolation; real time polymerase chain reaction; reverse transcription; RNA isolation |
Penerbit Universiti Sains Malaysia |
1394195X |
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Article |
Q3 |
394 |
12287 |
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812 |
Abadi M.R., Widyahening I.S., Sudarsono N.C., Tobing A.J. |
57223256005;54893154400;57201862518;57195719588; |
Incidence rate of musculoskeletal injuries among professional tennis players during 2019 international tournaments in Indonesia |
2021 |
Journal of Sports Science and Medicine |
20 |
2 |
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268 |
274 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105367811&doi=10.52082%2fjssm.2021.268&partnerID=40&md5=084058e65a62004039937034c05f34a7 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization (SEAMEO-RECFON) – Regional Centre for Food and Nutrition, Universitas Indonesia, Jakarta, Indonesia |
Abadi, M.R., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widyahening, I.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Southeast Asian Ministers of Education Organization (SEAMEO-RECFON) – Regional Centre for Food and Nutrition, Universitas Indonesia, Jakarta, Indonesia; Sudarsono, N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tobing, A.J., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Several studies have indicated that musculoskeletal injuries are common during a professional tennis competition. However, data from a tropical country like Indonesia is lacking. This study aimed to obtain the incidence rate and injury characteristics and identify risk factors of musculoskeletal injuries among professional tennis players competing in Indonesia under the International Tennis Federation (ITF). The study was a prospective cohort during professional tennis tournaments in Jakarta, Indonesia in 2019, consisting of the ITF Women’s Circuit Indonesia (two weeks) and ITF Men’s Future Indonesia (three weeks). All athletes were enrolled in this study. Injuries were assessed based on the ITF Consensus Statement. Incidence rate was the number of injuries per 1000 player hours (i.e., the total duration from before the match starts to completion of the match after the final point). The magnitude of risk was expressed as a relative risk (RR) and its 95% confidence interval (CI). Independent risk factors were identified using multivariate analyses. A total of 161 tennis players were enrolled; 71 (44.1%) were men. Their mean age was 22 years old. The incidence rate of musculoskeletal injuries was 30.8 injuries per 1000 player hours (95% CI: 28.2–33.5). The most common onset was acute injuries (61.1%), while the most common location and type of injury was the trunk (38.9%) and muscle strain (61.1%). Risk factors associated with musculoskeletal injury were higher body height, skill level, history of previous in-jury, and wet bulb globe temperature (WBGT) zone. There was no injury during the doubles matches. Previous injury was an independent risk factor (adjusted RR: 48.1 (95% CI: 11.3–155.0; p < 0.001). The incidence of musculoskeletal injuries among professional tennis player is considerably high. Factors associated with injury are body height, skill level, previous injury, and WBGT zone. Future injury prevention programmes should incor-porate the management of previous injuries and take into account the effect of environmental temperature. © Journal of Sports Science and Medicine (2021). |
Epidemiology; Incidence; Injury; Risk factors; Tennis; Tropical climate |
body height; competitive behavior; female; human; incidence; Indonesia; injury; male; motor performance; musculoskeletal system; physiology; prospective study; risk factor; skeletal muscle; tennis; tropic climate; trunk; young adult; Body Height; Competitive Behavior; Female; Humans; Incidence; Indonesia; Male; Motor Skills; Muscle, Skeletal; Musculoskeletal System; Prospective Studies; Risk Factors; Sprains and Strains; Tennis; Torso; Tropical Climate; Young Adult |
Journal of Sport Science and Medicine |
13032968 |
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34211319 |
Article |
Q1 |
815 |
5901 |
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814 |
Mirtha L.T., Siagian M., Tamin T.Z., Radi B., Soemarko D.S., Prijanti A.R., Irfanuddin M., Pelana R., Mansyur M. |
57193201450;6505956355;23476060900;6603494019;57192889490;57190863386;57223257669;57202117393;37085506800; |
The formula for calculating the predicted value of cardiorespiratory endurance using a foot rest-based cardiorespiratory exercise device |
2021 |
Science Progress |
104 |
2 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105102326&doi=10.1177%2f00368504211010637&partnerID=40&md5=2c4408c0d2414931797e6357c72a1d59 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Faculty of Sports Science, University State of Jakarta, Jakarta, Indonesia |
Mirtha, L.T., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siagian, M., Departement of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tamin, T.Z., Departement of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radi, B., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soemarko, D.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prijanti, A.R., Departement of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irfanuddin, M., Departement of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Pelana, R., Faculty of Sports Science, University State of Jakarta, Jakarta, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
This study developed a formula for calculating the predicted VO2 max value using a prototype model of foot-based cardiorespiratory exercise. Forty sedentary workers (20 men and 20 women) were enrolled via consecutive sampling. They underwent direct measurement of VO2 max using spiroergometry as the gold standard; the predicted VO2 max value was calculated using a prototype model of foot-based cardiorespiratory exercise, which was performed on consecutive days. Multivariate linear regression analysis was used to formulate the equation for the predicted VO2 max value by including potential contributing variables: gender, body height, body weight and heart rate. Bland–Altman test was used for assessing the agreement level for the predicted VO2 max value. The equation for the predicted VO2 max value was formulated as 3.2 + 0.15 optimal exercise heart rate −5.5 sexes (0 for men, 1 for women). The agreement level for the formula was acceptable in all measurement result ranges. The formula developed in this study can be used to measure the predicted VO2 max value with an acceptable agreement level. © The Author(s) 2021. |
Cardiorespiratory endurance; level of agreement; physical exercise; physical fitness; predicted VO2 max; sedentary work; sitting workers; VO2 max |
adult; article; body height; body weight; clinical article; endurance; exercise; female; foot; gender; gold standard; heart rate; human; human experiment; human tissue; linear regression analysis; male; sitting; worker |
SAGE Publications Ltd |
00368504 |
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33913389 |
Article |
Q2 |
310 |
14499 |
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824 |
Agung N.P., Nadhif M.H., Irdam G.A., Mochtar C.A. |
57222963984;57189057498;57194729795;6506558321; |
The Role of 3D-Printed Phantoms and Devices for Organ-specified Appliances in Urology |
2021 |
International Journal of Bioprinting |
7 |
2 |
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1 |
14 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104261313&doi=10.18063%2fIJB.V7I2.333&partnerID=40&md5=0bbeefb808ac4fbf51023802ccfa25db |
Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Technology Cluster, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Agung, N.P., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Nadhif, M.H., Department of Medical Physics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Technology Cluster, Indonesian Medical Education and Research Institute, Jakarta, Indonesia; Irdam, G.A., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Universitas Indonesia, Faculty of Medicine/Ciptomangunkusumo Central Hospital, Jakarta, Indonesia |
Urology is one of the fields that are always at the frontline of bringing scientific advancements into clinical practice, including 3D printing (3DP). This study aims to discuss and presents the current role of 3D-printed phantoms and devices for organ-specified applications in urology. The discussion started with a literature search regarding the two mentioned topics within PubMed, Embase, Scopus, and EBSCOhost databases. 3D-printed urological organ phantoms are reported for providing residents new insight regarding anatomical characteristics of organs, either normal or diseased, in a tangible manner. Furthermore, 3D-printed organ phantoms also helped urologists to prepare a pre-surgical planning strategy with detailed anatomical models of the diseased organs. In some centers, 3DP technology also contributed to developing specified devices for disease management. To date, urologists have been benefitted by 3D-printed phantoms and devices in the education and disease management of organs of in the genitourinary system, including kidney, bladder, prostate, ureter, urethra, penis, and adrenal. It is safe to say that 3DP technology can bring remarkable changes to daily urological practices. © 2021 Agung, et al. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International License (http://creativecommons.org/licenses/by-nc/4.0/), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
3D printing; Devices; Phantoms; Urology |
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Whioce Publishing Pte. Ltd. |
24248002 |
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Article |
Q1 |
1014 |
4306 |
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841 |
Wijaya D.A., Louisa M., Wibowo H., Taslim A., Permata T.B.M., Handoko, Nuryadi E., Kodrat H., Gondhowiardjo S.A. |
57222657856;41461551400;57217690943;57222661883;57197808751;57209984822;57197806814;57210639849;6508327402; |
The future potential of Annona muricata L. extract and its bioactive compounds as radiation sensitizing agents: Proposed mechanisms based on a systematic review |
2021 |
Journal of HerbMed Pharmacology |
10 |
2 |
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166 |
178 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103633859&doi=10.34172%2fjhp.2021.18&partnerID=40&md5=810428f36d6d7326990b348f1d1a958a |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Wijaya, D.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Wibowo, H., Laboratorium Terpadu, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Taslim, A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Handoko, Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia; Gondhowiardjo, S.A., Department of Radiation Oncology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta, Indonesia |
Despite technological advances in cancer treatment, especially in radiotherapy, many efforts are being made in improving cancer cell radio-sensitivity to increase therapeutic ratio and overcome cancer cell radio-resistance. In the present review, we evaluated the anticancer mechanism of Annona muricata L. (AM) leaves extract and its bioactive compounds such as annonaceous acetogenins, annomuricin, annonacin, or curcumin; and further correlated them with the potential of the mechanism to increase or to reduce cancer cells radio-sensitivity based on literature investigation. We see that AM has a promising future potential as a radio-sensitizer agent. © 2021 Nickan Research Institute. All rights reserved. |
Annona muricata; Bioactive compounds; Plant extract; Radio-sensitivity; Radiotherapy |
acetogenin; Annona muricata extract; annonacin; apoptosome; caspase 9; curcumin; cyclin D1; cyclin D2; death domain receptor signaling adaptor protein; Fas ligand; glucose transporter 4; glycogen synthase kinase; hypoxia inducible factor 1alpha; immunoglobulin light chain; interleukin 13; lactate dehydrogenase; mammalian target of rapamycin; mitogen activated protein kinase; mitogen activated protein kinase 1; mitogen activated protein kinase 3; phosphatidylserine; procaspase 3; protein Bax; protein bcl 2; protein mcl 1; protein p105; protein p50; protein p53; radiosensitizing agent; reactive oxygen metabolite; STAT3 protein; stress activated protein kinase; transcription factor RelA; transcription factor RelB; tumor necrosis factor; Annona muricata; apoptosis; B cell lymphoma; cell aging; |
Nickan Research Institute |
23455004 |
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Review |
Q3 |
341 |
13610 |
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