No records
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289 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Bardosono S., Sungkar S., Rachmat J., Hediyati M., Silalahi T. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;21933841000;57016857300;6507225348;57310558800;56275255400; |
Wound Healing in Diabetic Foot Ulcer Patients Using Combined Use of Platelet Rich Fibrin and Hyaluronic Acid, Platelet Rich Fibrin and Placebo: An Open Label, Randomized Controlled Trial |
2021 |
Acta medica Indonesiana |
53 |
3 |
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268 |
275 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117847076&partnerID=40&md5=089bf13006cbe4a09ad0a915462eec3b |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Kartika, R.W., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Alwi, I.; Suyatna, F.D.; Yunir, E.; Waspadji, S.; Immanuel, S.; Bardosono, S.; Sungkar, S.; Rachmat, J.; Hediyati, M.; Silalahi, T. |
BACKGROUND: Autologous platelet-rich fibrin (A-PRF) is an adjunctive method for diabetic foot ulcer (DFU) in addition to glycaemic control and debridement. This study aimed to evaluate the role of A-PRF + hyaluronic acid (HA), A-PRF and sodium chloride 0.9% (control) in DFU wound healing. Nowaday, the use of PRF autologous consider as adjuvant therapy in DFU treatment. METHODS: This open-label randomized controlled trial was conducted at Koja District Hospital and Gatot Soebroto Hospital from July 2019 to April 2020. DFU patients with wound duration of three months, Wagner-2, and ulcer size < 40 cm2 were recruited and randomly assigned into A-PRF + AH, A-PRF and control group. On day-0, day-3 and day -7, samples and photographs were taken. Samples were analysed with ELISA and photographs were analysed with ImageJ to calculate granulation index (GI). Statistical analysis was performed using SPSS version 20. RESULTS: Topical therapy with A-PRF + AH was associated with a significant increase in VEGF from day 0 (232.8 pg/mg) vs day 7 (544.5 pg/mg) compared to A-PRF on day 0 (185.7 pg/mg) vs day 7 (272.8 pg/mg), and the controls on day 0 (183.7 pg/mg) vs day 7 (167.4 pg/mg). On evaluation of VEGF swab, there is increasing significantly in A-PRF+HA group compare others group in day -3 ( p=0.022) and day -7 (p= 0.001).In the A-PRF + AH group, there was a significant decrease in IL-6 from day 0 (106.4 pg/mg) vs day 7 (88.7 pg/mg) compared with PRF on day 0 (91.9 pg/mg) vs day 7 (48,8 pg/mg). IL-6 was increased in the control group from day 0 (125.3 pg/mg) vs day 7 (167.9 pg/mg). On evaluation of IL-6 swab, there is decreasing significantly in A-PRF+HA group compare others group in day -7 (p= 0.041). CONCLUSION: The PRF + HA combination increased angiogenesis and reduced inflammation in DFUs and may represent a new DFU therapy. |
diabetic foot ulcer; hyaluronic acid; platelet-rich fibrin |
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NLM (Medline) |
01259326 |
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34611065 |
Article |
Q3 |
321 |
14162 |
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290 |
Shatri H., Prabu O.G., Tetrasiwi E.N., Faisal E., Putranto R., Ismail R.I. |
28767986500;57194132172;57267704700;57218497073;56074051000;57311408800; |
The Role of Online Psychotherapy in COVID-19: An Evidence Based Clinical Review |
2021 |
Acta medica Indonesiana |
53 |
3 |
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352 |
359 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117834929&partnerID=40&md5=ace8f85c837d6a06647336cc35e3f051 |
Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Shatri, H., Division of Psychosomatic and Palliative, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Prabu, O.G.; Tetrasiwi, E.N.; Faisal, E.; Putranto, R.; Ismail, R.I. |
BACKGROUND: COVID-19 is an infectious disease that is easily widespread and has clinical manifestations as mild, moderate, or severe disease. COVID-19 patients are required to be isolated during treatment to reduce transmission. This can cause anxiety and depression, which in turn worsens the patient's illness. Providing supportive psychotherapy can help provide a feeling of safety, comfort and calm for patients. The choice of method in providing supportive psychotherapy can be done online/teleconsultation or internet-based. This clinical review aims to determine the effect of online teleconsultation or internet-based psychotherapy on COVID-19 patients. METHODS: A systematic search was performed using online databases, such as PubMed, Cochrane, EBSCO/CINAHL and ProQuest. The identified articles were screened using eligibility criteria. There were 2 studies (Zhou et al, and Wei et al) which were analyzed critically using the Newcastle Ottawa Scale. RESULTS: Both studies showed that management of psychotherapy through teleconsultation or internet-based on COVID-19 patients can help relieve the patient's psychological symptoms. Zhou et al studied 63 suspected COVID-19 with 23.8% (n = 15) having a Hospital Anxiety Depression Scale (HADS) score of 8 or more. There was a significant decrease in HADS-A nxiety (HADS-A) scores (p <0.01) and HADS-Depression (HADS-D) scores (p <0.01) in 15 patients, and from the overall HADS scores (p < 0.01). Wei et al. Showed 17-HAMD and HAMA scores in the online psychological intervention group also showed a significant reduction in symptoms of depression and anxiety compared to controls. CONCLUSION: Psychotherapy through online teleconsultation or internet-based on COVID-19 patients can help relieve symptoms of anxiety and depression and teleconsultation and also effective in dealing with psychological complications in patients with COVID-19. |
anxiety; COVID-19; depression; online; teleconsultation |
anxiety; communicable disease control; depression; epidemiology; human; prevention and control; procedures; psychology; psychotherapy; teleconsultation; Anxiety; Communicable Disease Control; COVID-19; Depression; Humans; Internet-Based Intervention; Psychotherapy; Remote Consultation; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34611077 |
Article |
Q3 |
321 |
14162 |
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291 |
Rosana M., Asmara O.D., Pribadi R.R., Kalista K.F., Harimurti K. |
57310736300;57311469800;57194732282;57200425631;23473513200; |
Internal Medicine Residents' Perceptions of Point-of-Care Ultrasound in Residency Program: Highlighting the Unmet Needs |
2021 |
Acta medica Indonesiana |
53 |
3 |
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299 |
307 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117823517&partnerID=40&md5=913ad9734aff00b93a00fe56082dca20 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia |
Rosana, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General HospitalJakarta, Indonesia; Asmara, O.D.; Pribadi, R.R.; Kalista, K.F.; Harimurti, K. |
BACKGROUND: Point-of-care ultrasound (POCUS) is increasingly used in internal medicine field. Ultrasound training has been part of the training provided in the Internal Medicine Residency Program (IMRP). The aim of this study is to examine the residents' needs and perceptions regarding their competency and needs of POCUS. METHODS: We conducted a cross-sectional descriptive study using secondary data from a survey among internal medicine residents at the Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital. The survey was conducted to evaluate and improve the curriculum in IMRP. RESULTS: A total of 175 out of 197 residents (88.8%) completed the questionnaire. Almost all the residents (99.4%) agreed that POCUS is a beneficial must-have skill during residency. Nevertheless, only 40% of residents identified themselves as competent in POCUS. Sixty-two percent residents reckoned that the training received during the residency program is insufficient. They indicated that the most useful skills are US of hepatobiliary, lungs, heart, kidneys, and US-guided procedures. CONCLUSION: This study confirms that there is a need for POCUS training for IM residents, as the majority perceived themselves as unable to perform US. It is necessary to optimize the training provided to ensure proficiency. |
internal medicine; Internship; residency; ultrasonography |
adult; article; curriculum; female; general hospital; heart; human; human experiment; Indonesia; internal medicine; kidney; lung; male; perception; point of care ultrasound; questionnaire; resident; skill |
NLM (Medline) |
01259326 |
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34611069 |
Article |
Q3 |
321 |
14162 |
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292 |
Iman R.P., Junita T., Rachman R.I., Syam A.F. |
57218324172;57310672300;57310137500;8443384400; |
Risk factor, diagnosis, and current treatment of H. pylori Infection in Indonesia: A Literature Review |
2021 |
Acta medica Indonesiana |
53 |
3 |
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331 |
338 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117760916&partnerID=40&md5=ce13806d99f6c0a46477f70903de63ef |
Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Iman, R.P., Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Junita, T.; Rachman, R.I.; Syam, A.F. |
Helicobacter pylori (H. pylori) infection has become an emerging problem in Indonesia despite its relatively low prevalence as opposed to other Southeast Asian and Asian countries. Strains containing less virulent genotypes predominantly found in Indonesia is suggested to be the rationale for why the disease prevalence, as well as its gastric cancer complication, remain inferior in respect of neighboring counterparts. Although endoscopic evaluation is still necessary to determine the gastric mucosal status of those infected with H. pylori, the infection itself can be easily diagnosed with test-and-treat strategy especially in areas with limited resources. Several findings revealed high rates of antibiotic resistance varying among Indonesian regions and ethnicities, suggesting that triple therapy regimen may not be suitable for all population. Whereas treatment should be based on the pattern of resistance in respected region, novel regimens involving furazolidone, rifabutin, and sitafloxacin are proposed as potential drugs of choice to eradicate H. pylori infection. In order to determine the adequate approach for H. pylori infection in Indonesia, further multicenter studies involving larger sample size should be conducted. |
current treatment; diagnosis; Helicobacter pylori; infection; risk factor |
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NLM (Medline) |
01259326 |
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34611074 |
Article |
Q3 |
321 |
14162 |
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293 |
Saifuddin A., Koesnoe S., Kurniati N., Sirait S., Arisanty R., Yunihastuti E. |
57217827222;26028015000;57310154400;56426927400;57204115712;57221273925; |
COVID Arm After Moderna Booster in Healthcare Worker: A Case Report |
2021 |
Acta medica Indonesiana |
53 |
3 |
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326 |
330 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117747171&partnerID=40&md5=f3f6d4890049ab19cad5ba0a8a16a045 |
Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Saifuddin, A., Division of Allergy and Clinical Immunology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Koesnoe, S.; Kurniati, N.; Sirait, S.; Arisanty, R.; Yunihastuti, E. |
SARS CoV-2 virus has infected more than 200 million people worldwide and more than 4.4 million in Indonesia. The vaccination program has become one of the solutions launched by many countries globally, including Indonesia, to reduce the transmission rate of COVID-19. Various vaccination platforms are produced, such as inactivated, viral vector, mRNA, and protein subunit. The vaccination booster program with mRNA platform (Moderna) was launched by the Indonesian government to give better protection for health care workers, particularly from delta variant. In this case report, we discuss one of the typical side effects of Moderna vaccine, which is referred to as the COVID arm. |
booster; COVID arm; COVID-19; healthcare worker; Moderna; vaccination |
analgesic agent; elasomeran; paracetamol; administration and dosage; adverse drug reaction; adverse event; biopsy; case report; delayed hypersensitivity; epidemiology; female; fever; human; injection site reaction; middle aged; pathology; pathophysiology; physician; prevention and control; procedures; skin; treatment outcome; vaccination; Acetaminophen; Analgesics, Non-Narcotic; Biopsy; COVID-19; COVID-19 Vaccines; Drug-Related Side Effects and Adverse Reactions; Female; Fever; Humans; Hypersensitivity, Delayed; Injection Site Reaction; Middle Aged; Physicians; SARS-CoV-2; Skin; Treatment Outcome; Vaccination |
NLM (Medline) |
01259326 |
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34611073 |
Article |
Q3 |
321 |
14162 |
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294 |
Nelwan E.J., Tunjungputri R.N., Wardani R.S., Wahyuningsih R. |
14527452900;56342194400;47562102900;6507268400; |
Black Fungus Complicated with COVID-19 in a Man with Underlying Non-Hodgkin's Lymphoma |
2021 |
Acta medica Indonesiana |
53 |
3 |
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349 |
351 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117746727&partnerID=40&md5=9ffcb6f5c08a7096c40aca053f41d236 |
1. Division of Tropical and Infectious Disease. Department of Internal Medicine, Indonesia. 2. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nelwan, E.J., 1. Division of Tropical and Infectious Disease. Department of Internal Medicine, Indonesia. 2. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Tunjungputri, R.N.; Wardani, R.S.; Wahyuningsih, R. |
COVID-19 is a disease reported to suppress cellular immunity. This may lead to the development of opportunistic infections, among others black fungus, or mucormycosis. On the other hand, pre-existing defect in immunity may render patients susceptible to both mucormycosis and COVID-19. Mucormycosis is a relatively rare fungal infection with rapid progression unless diagnosed promptly and treated adequately, and urgent surgical and medical intervention is lifesaving. The manifestation of mucormycosis largely depends on the presence of exposure to the pathogen and the existing risk factor of the host. As black fungus is locally invasive, the majority of cases will involve tissue damage with local destruction and contiguous spread to nearby structure. We here with present a case of black fungus complicated with COVID-19 in a man with underlying non-Hodgkin's lymphoma. |
black fungus; COVID-19; non-hodgkin lymphoma |
adult; biopsy; case report; complication; debridement; diagnosis; disease exacerbation; human; isolation and purification; male; microbiology; Mucorales; mucormycosis; nonhodgkin lymphoma; nose disease; nose septum; pathology; pathophysiology; patient isolation; procedures; therapy; time to treatment; x-ray computed tomography; Adult; Biopsy; COVID-19; Debridement; Disease Progression; Humans; Lymphoma, Non-Hodgkin; Male; Mucorales; Mucormycosis; Nasal Septum; Nose Diseases; Patient Isolation; SARS-CoV-2; Time-to-Treatment; Tomography, X-Ray Computed |
NLM (Medline) |
01259326 |
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34611076 |
Article |
Q3 |
321 |
14162 |
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295 |
Sugiharto P., Ramlan A.A.W. |
57286412100;57195941841; |
Effectiveness of mindfulness-based intervention technique in reducing stress levels of anesthesiology and intensive therapy residents |
2021 |
Bali Journal of Anesthesiology |
5 |
3 |
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166 |
170 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116416960&doi=10.4103%2fbjoa.bjoa_251_20&partnerID=40&md5=ec537b920b0bac4177ea8de114c87660 |
Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Sugiharto, P., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Ramlan, A.A.W., Department of Anesthesiology and Intensive Care, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: An anesthesiologist is expected to be able to manage intraoperative crises that can occur at any time. We aimed to determine the effectiveness of mindfulness-based intervention (MBI) technique in reducing stress levels of anesthesiology and intensive therapy residents at the Faculty of Medicine, University of Indonesia. Materials and Methods: This research was an experimental study with paired one group design. The MBI program lasted 4 weeks, consisted of one formal face-to-face training and 4 weeks of informal training (homework). Thirteen study subjects met the inclusion criteria and did not enter the exclusion criteria. One study subject was excluded because the subject did not complete the informal training. Data collection on the Perceived Stress Scale 10-Item (PSS-10) was conducted before and after training. Results: The average age of study subjects was 29.75 years; 75% are women. Four participants were in the 1 st year of education (33%), 3 participants were in the 2 nd year of education (25%), 2 participants were in the 3 rd year of education (16.67%), and 3 participants were in the 4 th year of education (25%). PSS-10 score in the study subjects significantly decreased after applying the MBI technique for 4 weeks (P = 0.001). Conclusion: MBI is effective in reducing stress levels of anesthesiology and intensive therapy residents at the-blinded. © 2020 Bali Journal of Anesthesiology | Published by Wolters Kluwer-Medknow. |
Anesthesiologist; mindfulness; resident; stress |
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Wolters Kluwer Medknow Publications |
25492276 |
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Article |
#N/A |
#N/A |
#N/A |
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296 |
Pudjiadi A.H., Pramesti D.L., Pardede S.O., Djer M.M., Rohsiswatmo R., Kaswandani N. |
18435202300;57286438600;57210394278;12771087900;55533574600;57195941745; |
Validation of the vasoactive-inotropic score in predicting pediatric septic shock mortality: A retrospective cohort study |
2021 |
International Journal of Critical Illness and Injury Science |
11 |
3 |
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117 |
122 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116401748&doi=10.4103%2fIJCIIS.IJCIIS_98_20&partnerID=40&md5=c4a8675dca5d2e706bb5225b224574e6 |
Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pramesti, D.L., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Pardede, S.O., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Rohsiswatmo, R., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Child-Health, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Mortality in pediatric septic shock remains very high. Vasoactive-inotropic score (VIS) is widely used to predict prognosis in patients with heart disease. It is a simple method that was initially used as a predictor of morbidity and mortality in postoperative patients with congenital heart diseases. Previous reports showed that high VIS score was associated with high mortality in pediatric sepsis. However, its discriminative value remains unclear. We aim to explore the discriminative value of VIS in predicting mortality in pediatric septic shock patients. Methods: We conducted a retrospective cohort study on medical records of septic shock patients who received care in the pediatric intensive care unit (PICU). We screened medical records of pediatric patients which were diagnosed with septic shock and admitted to the PICU and received vasoactive/inotropic score for more than 8 h. Other supporting examination results were recorded, such as organ function evaluation for calculation of Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score. The outcome of patients was recorded. The receiver operating curve was constructed to calculate the area under the curve (AUC), sensitivity, and specificity of each cutoff point. Results: We obtained the optimum cutoff point of VIS > 11 with 78.87% sensitivity and 72.22% specificity. AUC positive was 0.779 (P < 0.001); predictive value and negative predictive value were 91.80% and 46.43%, respectively. Conclusion: VIS > 11 has a good ability to predict mortality in children with septic shock. © 2021 International Journal of Critical Illness and Injury Science | Published by Wolters Kluwer-Medknow. |
Mortality; pediatrics; sepsis; vasoactive-inotropic score |
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Wolters Kluwer Medknow Publications |
22295151 |
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Review |
Q3 |
274 |
15730 |
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298 |
Sutandi N., Lee F. |
57201654034;57262177400; |
Vitreoretinal abnormalities in corona virus disease 2019 patients: What we know so far |
2021 |
Taiwan Journal of Ophthalmology |
11 |
3 |
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232 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115110995&doi=10.4103%2ftjo.tjo_30_21&partnerID=40&md5=36ea488504463bec350d4e4cb30186ed |
Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Sutandi, N., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Lee, F., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
The coronavirus disease 2019 (COVID-19) has become a global pandemic since December 2019. Although COVID-19 primarily affects the respiratory systems, it has become abundantly clear that it involves multiple organs including the heart, kidney, skin, and brain. Neuro-ophthalmic signs and anterior segment inflammation of the eyes were documented in COVID-19 patients recently. Small but growing number of literatures has also reported the cases of new onset vitreoretinal disorders related to COVID-19 infection. A comprehensive search from four online databases was done. Findings show vitreoretinal involvement in COVID-19 patients including the central retinal vein occlusion, central retinal artery occlusion, reactivation of previous uveitis, chorioretinitis, macular hemorrhage, acute macular neuroretinopathy, paracentral acute middle maculopathy, vitritis with outer retinal abnormalities, varicella zoster virus-related acute retinal necrosis in immunocompromised patient, and other posterior segment pathological changes. The hypotheses for potential pathogenesis of these manifestations are direct viral ocular infection and thromboembolic complications secondary to the hyperinflammatory response. This is the first review article, which provides an overview of current evidence regarding the vitreoretinal manifestations in COVID-19 patients. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
COVID-19; funduscopy; posterior segment; SARS-CoV-2; vitreoretinal abnormalities |
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Wolters Kluwer Medknow Publications |
22115056 |
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Review |
Q3 |
519 |
9760 |
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324 |
Lazarus G., Suhardi I.P., Wiyarta E., Rasyidah R.A., Barliana J.D. |
57214599425;57222253831;57221521342;57222252100;57200964187; |
Is there a need to reconsider the use of metformin in COVID-19 patients with type 2 diabetes mellitus? |
2021 |
International Journal of Diabetes in Developing Countries |
41 |
3 |
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377 |
382 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102035672&doi=10.1007%2fs13410-021-00924-w&partnerID=40&md5=6553878fa250ce9823f68e0c2659a9ff |
Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Suhardi, I.P., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Rasyidah, R.A., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, RW 5, Kenari, Kec. Senen, Kota Jakarta Pusat, Jakarta, 10430, Indonesia; Barliana, J.D., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: Diabetes has been linked with poorer outcomes in coronavirus disease (COVID-19) patients. However, the question to whether continue or withdraw metformin therapy in COVID-19 patients with type 2 diabetes mellitus remains contentious. This study aims to investigate the association between metformin and poor COVID-19 outcomes. Methods: Eligible studies published up to 21 October 2020 were included and appraised for validity, importance, and applicability. The included studies were further ranked according to the level of evidence (LOE). Results: Nine studies were included for further assessments, of which seven studies stated that metformin was not associated with poor COVID-19 outcomes (LOE II-V), while the other two with poorer designs stated otherwise (LOE V). Although metformin may increase the risk of developing acidosis and lactic acidosis (LOE IV), the observed risks were more accentuated in patients with severe COVID-19 disease or kidney impairment and in patients with > 2 daily metformin doses. Interestingly, one study revealed that metformin may even yield therapeutic role in reducing the risk of COVID-19 mortality (LOE II), although further studies are required to confirm these findings. Conclusions: Our findings indicated that metformin may be safely continued in COVID-19 patients. The benefit of metformin therapy with simultaneous continuous monitoring of COVID-19 severity and kidney function may outweigh the risks of lactic acidosis, of which incidence is relatively rare. © 2021, Research Society for Study of Diabetes in India. |
COVID-19; Metformin; Prognosis; Type 2 diabetes mellitus |
hemoglobin A1c; metformin; acidosis; adult; Article; case report; clinical article; coronavirus disease 2019; diabetic patient; disease course; disease severity; drug safety; estimated glomerular filtration rate; glycemic control; human; kidney failure; kidney function; lactic acidosis; male; middle aged; mortality; mortality risk; non insulin dependent diabetes mellitus; prognosis; systematic review |
Springer |
09733930 |
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Article |
Q3 |
205 |
19024 |
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