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Turana Y., Tengkawan J., Chia Y.C., Shin J., Chen C.-H., Park S., Tsoi K., Buranakitjaroen P., Soenarta A.A., Siddique S., Cheng H.-M., Tay J.C., Teo B.W., Wang T.-D., Kario K. |
56083326000;57201472878;57204080905;54791393300;7501963868;8556278400;16065259000;6603376248;6507634613;57210091066;57026688600;24330212600;23570166200;7405566618;7102633390; |
Mental health problems and hypertension in the elderly: Review from the HOPE Asia Network |
2021 |
Journal of Clinical Hypertension |
23 |
3 |
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504 |
512 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097219445&doi=10.1111%2fjch.14121&partnerID=40&md5=67d4846f474282e2b6bd32d52a692db9 |
School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia; Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Jakarta, Indonesia; Punjab Medical Center, Lahore, Pakistan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Center for Evidence-Based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
Turana, Y., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Tengkawan, J., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Chia, Y.C., Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Shin, J., Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Chen, C.-H., Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Park, S., Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; Tsoi, K., JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Buranakitjaroen, P., Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Soenarta, A.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Jakarta, Indonesia; Siddique, S., Punjab Medical Center, Lahore, Pakistan; Cheng, H.-M., Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Center for Evidence-Based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Public Health, National Yang-Ming University School of Medicine, Taipei, Taiwan; Tay, J.C., Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Teo, B.W., Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Wang, T.-D., Department of Internal Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan; Kario, K., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
The “triple burden” of aging population, hypertension, and mental health problems making elderly in Asia is more vulnerable. There is evidence of a bidirectional relationship between mental health and hypertension, which results in lower quality of life, lower rate of treatment adherence, and higher mortality among elderly individuals. It is essential to overcome known barriers and care for the elderly with high-risk factors in order to address these burdens. This review revealed that elderly with hypertension were more likely to suffer from depression and anxiety. Therefore, debunking myths, creating awareness regarding mental health, and increasing access to mental health resources through holistic community-based programs would greatly reduce such problems and optimize the chances of success in controlling hypertension-related problems. © 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC |
Asia; elderly; hypertension; mental health |
antihypertensive agent; aged; anxiety; Asia; cardiovascular disease; cerebrovascular disease; community mental health service; comorbidity; depression; disease association; disease burden; elderly care; health care access; high risk population; human; hypertension; late life depression; life stress; loneliness; medication compliance; mental disease; mental health; motivation; patient compliance; Review; anxiety disorder; hypertension; mental health; quality of life; Aged; Anxiety Disorders; Asia; Humans; Hypertension; Mental Health; Quality of Life |
John Wiley and Sons Inc |
15246175 |
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33283971 |
Review |
Q2 |
909 |
5078 |
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552 |
Chang H.-C., Cheng H.-M., Chen C.-H., Wang T.-D., Soenarta A.A., Turana Y., Teo B.W., Tay J.C., Tsoi K., Wang J.-G., Kario K. |
57208131716;57026688600;7501963868;7405566618;6507634613;56083326000;23570166200;24330212600;16065259000;57211730247;7102633390; |
Dietary intervention for the management of hypertension in Asia |
2021 |
Journal of Clinical Hypertension |
23 |
3 |
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538 |
544 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097029615&doi=10.1111%2fjch.14116&partnerID=40&md5=dd0dddd11a11196e4a83b9fd85ea06f2 |
Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medical Education, Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong; Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
Chang, H.-C., Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan; Cheng, H.-M., Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, Department of Medical Education, Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Chen, C.-H., Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, Department of Medical Education, Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Wang, T.-D., Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan; Soenarta, A.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Turana, Y., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Teo, B.W., Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Tay, J.C., Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Tsoi, K., JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong; Wang, J.-G., Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Kario, K., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
Hypertension is among the leading global risks for premature death. As the risks substantially increase along with the elevated blood pressure, a small reduction of blood pressure could have prevented numerous cardiovascular events in general population. Evidence has shown that dietary intervention is a cost-effective strategy that has been broadly advocated in the published guidelines. However, the implementation could be limited by different food cultures. This review details the mechanisms of each dietary intervention approach, evidence, and the implications in Asian populations, and the perspective of future research. © 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC |
dietary intervention; hypertension |
aldosterone; calcium; catecholamine; magnesium; potassium; renin; Asia; blood pressure regulation; body weight loss; calcium blood level; caloric restriction; cardiovascular risk factor; cost effectiveness analysis; cultural anthropology; DASH diet; diastolic blood pressure; diet supplementation; diet therapy; dietary pattern; disease association; electrolyte intake; evidence based medicine; fluid retention; food security; human; hyperinsulinemia; hypertension; ideal body weight; insulin resistance; lifestyle modification; magnesium blood level; Mediterranean diet; mortality; obesity; potassium blood level; potassium intake; practice guideline; renin angiotensin aldosterone system; Review; sodium restriction; sodium retention; sodium transport; sodium urine level; systolic blood pressure; |
John Wiley and Sons Inc |
15246175 |
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33274585 |
Review |
Q2 |
909 |
5078 |
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553 |
Turana Y., Tengkawan J., Chia Y.C., Nathaniel M., Wang J.-G., Sukonthasarn A., Chen C.-H., Minh H.V., Buranakitjaroen P., Shin J., Siddique S., Nailes J.M., Park S., Teo B.W., Sison J., Ann Soenarta A., Hoshide S., Tay J.C., Prasad Sogunuru G., Zhang Y., Verma N., Wang T.-D., Kario K., the HOPE Asia Network |
56083326000;57201472878;57204080905;57220063330;57211730247;12793132900;7501963868;57211946145;6603376248;54791393300;57210091066;57204676117;8556278400;23570166200;36764809200;56545726300;6603859769;24330212600;57220061819;56183109800;7102496979;7405566618;7102633390; |
Hypertension and stroke in Asia: A comprehensive review from HOPE Asia |
2021 |
Journal of Clinical Hypertension |
23 |
3 |
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513 |
521 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096667710&doi=10.1111%2fjch.14099&partnerID=40&md5=85c747eb49b66c56895a7650e9a82984 |
School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia; Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Department of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Cardiology, Hue University Hospital, Hue University, Hue City, Viet Nam; Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Punjab Medical Center, Lahore, Pakistan; University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines; Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; Division of Nephrology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore; Division of Nephrology, Department of Medicine, National University Health System, Singapore City, Singapore; Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; MIOT International Hospital, Chennai, India; College of Medical Sciences, Kathmandu University, Bharatpur, Nepal; Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Physiology, King George's Medical University, Lucknow, India; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan |
Turana, Y., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Tengkawan, J., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Chia, Y.C., Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Nathaniel, M., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Wang, J.-G., Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Sukonthasarn, A., Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Chen, C.-H., Department of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Minh, H.V., Department of Cardiology, Hue University Hospital, Hue University, Hue City, Viet Nam; Buranakitjaroen, P., Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Shin, J., Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Siddique, S., Punjab Medical Center, Lahore, Pakistan; Nailes, J.M., University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines; Park, S., Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; Teo, B.W., Division of Nephrology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore, Division of Nephrology, Department of Medicine, National University Health System, Singapore City, Singapore; Sison, J., Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines; Ann Soenarta, A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Hoshide, S., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Tay, J.C., Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Prasad Sogunuru, G., MIOT International Hospital, Chennai, India, College of Medical Sciences, Kathmandu University, Bharatpur, Nepal; Zhang, Y., Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Verma, N., Department of Physiology, King George's Medical University, Lucknow, India; Wang, T.-D., Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan; Kario, K., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; the HOPE Asia Network |
Stroke is the primary cause of disability and vascular death worldwide, including Asia. Asian characteristics that differ from the West lead to higher stroke incidence. Stroke epidemiology studies in Asia have shown varying levels of mortality, incidence, prevalence, and burden of disease. Hypertension is the most prevalent risk factor found in Asia. Besides ethnicity that is associated with stroke incidence, both systolic blood pressure, diastolic blood pressure, and blood pressure variability are positively correlated with stroke incidence. Post-stroke cognitive impairment is one of the sequelae that affect one-third of stroke survivors and has become a significant public health concern that is often neglected despite its increasing prevalence. Therefore, it is very important to prevent recurrence by treating stroke optimally and effectively. Increasing awareness and treatment adherence to hypertension, the leading risk factor for stroke, became the main goal in several countries in Asia. © 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. |
Asia; hypertension; stroke |
Asia; awareness; blood pressure variability; cerebrovascular accident; clinical effectiveness; dementia; diastolic blood pressure; disease burden; global health; human; hypertension; incidence; medication compliance; mortality rate; post stroke dementia; prevalence; recurrent disease; Review; risk factor; systolic blood pressure; blood pressure; cerebrovascular accident; hypertension; Asia; Blood Pressure; Humans; Hypertension; Incidence; Risk Factors; Stroke |
John Wiley and Sons Inc |
15246175 |
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33190399 |
Review |
Q2 |
909 |
5078 |
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554 |
Ross J., Jiamsakul A., Kumarasamy N., Azwa I., Merati T.P., Do C.D., Lee M.P., Ly P.S., Yunihastuti E., Nguyen K.V., Ditangco R., Ng O.T., Choi J.Y., Oka S., Sohn A.H., Law M. |
57193109926;55285745500;7003549856;55553159100;57203678680;56658396600;56143671100;9743902800;57221273925;56370854300;55406840800;57203665233;48761023600;57216171596;7006405275;57222965808; |
Virological failure and HIV drug resistance among adults living with HIV on second-line antiretroviral therapy in the Asia-Pacific |
2021 |
HIV Medicine |
22 |
3 |
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201 |
211 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096661480&doi=10.1111%2fhiv.13006&partnerID=40&md5=9ef6bceb9ed5dc756f178320119cc3c4 |
TREAT Asia/amfAR –The Foundation for AIDS Research, Bangkok, Thailand; The Kirby Institute, UNSW Sydney, Kensington, NSW, Australia; Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Infectious Diseases Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Bach Mai Hospital, Hanoi, Viet Nam; Queen Elizabeth Hospital, Hong Kong; National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Faculty of Medicine, Universitas Indonesia - Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; National Hospital for Tropical Diseases, Hanoi, Viet Nam; Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Tan Tock Seng Hospital, Singapore, Singapore; Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; National Center for Global Health and Medicine, Tokyo, Japan |
Ross, J., TREAT Asia/amfAR –The Foundation for AIDS Research, Bangkok, Thailand; Jiamsakul, A., The Kirby Institute, UNSW Sydney, Kensington, NSW, Australia; Kumarasamy, N., Chennai Antiviral Research and Treatment Clinical Research Site (CART CRS), VHS-Infectious Diseases Medical Centre, VHS, Chennai, India; Azwa, I., Infectious Diseases Unit, Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Merati, T.P., Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia; Do, C.D., Bach Mai Hospital, Hanoi, Viet Nam; Lee, M.P., Queen Elizabeth Hospital, Hong Kong; Ly, P.S., National Center for HIV/AIDS, Dermatology & STDs, Phnom Penh, Cambodia; Yunihastuti, E., Faculty of Medicine, Universitas Indonesia - Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nguyen, K.V., National Hospital for Tropical Diseases, Hanoi, Viet Nam; Ditangco, R., Research Institute for Tropical Medicine, Muntinlupa City, Philippines; Ng, O.T., Tan Tock Seng Hospital, Singapore, Singapore; Choi, J.Y., Division of Infectious Diseases, Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea; Oka, S., National Center for Global Health and Medicine, Tokyo, Japan; Sohn, A.H., TREAT Asia/amfAR –The Foundation for AIDS Research, Bangkok, Thailand; Law, M., The Kirby Institute, UNSW Sydney, Kensington, NSW, Australia |
Objectives: To assess second-line antiretroviral therapy (ART) virological failure and HIV drug resistance-associated mutations (RAMs), in support of third-line regimen planning in Asia. Methods: Adults > 18 years of age on second-line ART for ≥ 6 months were eligible. Cross-sectional data on HIV viral load (VL) and genotypic resistance testing were collected or testing was conducted between July 2015 and May 2017 at 12 Asia-Pacific sites. Virological failure (VF) was defined as VL > 1000 copies/mL with a second VL > 1000 copies/mL within 3–6 months. FASTA files were submitted to Stanford University HIV Drug Resistance Database and RAMs were compared against the IAS-USA 2019 mutations list. VF risk factors were analysed using logistic regression. Results: Of 1378 patients, 74% were male and 70% acquired HIV through heterosexual exposure. At second-line switch, median [interquartile range (IQR)] age was 37 (32–42) years and median (IQR) CD4 count was 103 (43.5–229.5) cells/µL; 93% received regimens with boosted protease inhibitors (PIs). Median duration on second line was 3 years. Among 101 patients (7%) with VF, CD4 count > 200 cells/µL at switch [odds ratio (OR) = 0.36, 95% confidence interval (CI): 0.17–0.77 vs. CD4 ≤ 50) and HIV exposure through male–male sex (OR = 0.32, 95% CI: 0.17–0.64 vs. heterosexual) or injecting drug use (OR = 0.24, 95% CI: 0.12–0.49) were associated with reduced VF. Of 41 (41%) patients with resistance data, 80% had at least one RAM to nonnucleoside reverse transcriptase inhibitors (NNRTIs), 63% to NRTIs, and 35% to PIs. Of those with PI RAMs, 71% had two or more. Conclusions: There were low proportions with VF and significant RAMs in our cohort, reflecting the durability of current second-line regimens. © 2020 British HIV Association |
Asia; drug resistance; HIV; second-line antiretroviral therapy; virological failure |
anti human immunodeficiency virus agent; emtricitabine; Human immunodeficiency virus proteinase inhibitor; integrase inhibitor; lamivudine; lopinavir; nonnucleoside reverse transcriptase inhibitor; raltegravir; RNA directed DNA polymerase inhibitor; tenofovir; adult; antiretroviral therapy; antiviral resistance; Article; Cambodia; CD4 lymphocyte count; cohort analysis; comparative study; cross-sectional study; data base; female; gene mutation; genotyping technique; heterosexuality; Hong Kong; human; Human immunodeficiency virus; Human immunodeficiency virus infected patient; Human immunodeficiency virus infection; India; Indonesia; injection drug user; Japan; major clinical study; Malaysia; male; men who have sex with men; middle aged; Philippines; priority journal; prospective study; retr |
Blackwell Publishing Ltd |
14642662 |
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33151020 |
Article |
Q1 |
1530 |
2201 |
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579 |
Lee C.-C., Kwa A.L.H., Apisarnthanarak A., Feng J.-Y., Gluck E.H., Ito A., Karuniawati A., Periyasamy P., Pratumvinit B., Sharma J., Solante R., Swaminathan S., Tyagi N., Vu D.M., Zirpe K., Schuetz P. |
57216571107;57277379200;6603905554;24168534700;7003341685;37007598100;54886816200;57218573063;35722893000;12545686500;8728553100;56354453600;56471440500;57214066572;56521747700;35235208800; |
Erratum: Procalcitonin (PCT)guided antibiotic stewardship in Asia-Pacific countries: Adaptation based on an expert consensus meeting. (Clin Chem Lab Med (2020) 58:12 (1983–91) Doi:10.1515/cclm-2019-1122) |
2021 |
Clinical Chemistry and Laboratory Medicine |
59 |
3 |
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631 |
632 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100458517&doi=10.1515%2fcclm-2020-1724&partnerID=40&md5=b517d7656483da02741274bbd916bf57 |
Singapore General Hospital, Singapore, Singapore; Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore; Division of Infectious Diseases, Thammasart University Hospital, Bangkok, Thailand; Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Critical Care Services, Swedish Covenant Hospital, Chicago, IL, United States; Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Department of Microbiology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Infectious Disease Unit, PPUKM (HCTM), Hospital Canselor Tuanku Muhriz UKM (HCTM), Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia; Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Artemis Hospital Critical Care Medicine, Gurgaon, India; Adult Infectious Diseases and Tropical Medicine, San Lazaro Hospital, Manila, Philippines; Infectious Diseases, Gleneagles Global Hospitals, Chennai and Bengaluru, India; Institute of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, Delhi, India; Critical Care Department, National Hospital of Tropical Diseases, Hanoi, Viet Nam; Department of Neuro Critical Care, Ruby Hall Clinic, Grant Medical Foundation, Pune, India; Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland; University of Basel, Basel, Switzerland |
Lee, C.-C., Singapore General Hospital, Singapore, Singapore; Kwa, A.L.H., Emerging Infectious Diseases Program, Duke-National University of Singapore Medical School, Singapore, Singapore, Division of Infectious Diseases, Thammasart University Hospital, Bangkok, Thailand; Apisarnthanarak, A., Department of Chest Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Feng, J.-Y., Critical Care Services, Swedish Covenant Hospital, Chicago, IL, United States; Gluck, E.H., Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Ito, A., Department of Respiratory Medicine, Ohara Healthcare Foundation, Kurashiki Central Hospital, Okayama, Japan; Karuniawati, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Periyasamy, P., Infectious Disease Unit, PPUKM (HCTM), Hospital Canselor Tuanku Muhriz UKM (HCTM), Universiti Kebangsaan Malaysia Medical Centre (UKMMC), Kuala Lumpur, Malaysia; Pratumvinit, B., Department of Clinical Pathology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Sharma, J., Artemis Hospital Critical Care Medicine, Gurgaon, India; Solante, R., Adult Infectious Diseases and Tropical Medicine, San Lazaro Hospital, Manila, Philippines; Swaminathan, S., Infectious Diseases, Gleneagles Global Hospitals, Chennai and Bengaluru, India; Tyagi, N., Institute of Critical Care and Emergency Medicine, Sir Ganga Ram Hospital, Delhi, India; Vu, D.M., Critical Care Department, National Hospital of Tropical Diseases, Hanoi, Viet Nam; Zirpe, K., Department of Neuro Critical Care, Ruby Hall Clinic, Grant Medical Foundation, Pune, India; Schuetz, P., Department of Internal Medicine, Kantonsspital Aarau, Aarau, Switzerland, University of Basel, Basel, Switzerland |
There is typo in Figure 1 and Figure 2 of this article. Instead of “… repeated testing or monitoring for discontinuation …” it should read “… repeated testing for monitoring and discontinuation …” (see corrected Figures). © 2021 De Gruyter. All rights reserved. |
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erratum |
De Gruyter Open Ltd |
14346621 |
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33554531 |
Erratum |
Q1 |
977 |
4522 |
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582 |
Scheffler C., Hermanussen M., Soegianto S.D.P., Homalessy A.V., Touw S.Y., Angi S.I., Ariyani Q.S., Suryanto T., Matulessy G.K.I., Fransiskus T., Safira A.V.C., Puteri M.N., Rahmani R., Ndaparoka D.N., Payong M.K.E., Indrajati Y.D., Purba R.K.H., Manubulu R.M., Julia M., Pulungan A.B. |
22836040300;7005909056;57212268744;57209200014;57209199756;57221800920;57221801196;57221800170;57221808632;57221804338;57221806887;57221809375;57221807473;57221800477;57209199238;57221808668;57221803203;57221808341;14019743100;57192905981; |
Stunting as a synonym of social disadvantage and poor parental education |
2021 |
International Journal of Environmental Research and Public Health |
18 |
3 |
1350 |
1 |
13 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100239177&doi=10.3390%2fijerph18031350&partnerID=40&md5=33700577101c6821f63520cfa18f471d |
Institute of Biochemistry and Biology, Human Biology, University of Potsdam, Potsdam, 14469, Germany; University of Kiel, Aschauhof, Eckernförde-Altenhof, 24340, Germany; Indonesian Pediatric Society, East Nusa Tenggara Branch, Kupang-East Nusa Tenggara, Kupang, 85351, Indonesia; Indonesian Medical Association Branch, Kupang, 85351, Indonesia; DDS PPDGS Konservasi Gigi FKG UGM, Jl. Sekip Utara, Sumatra, Medan, 20153, Indonesia; Faculty of Medicine, Nusa Cendana University, Kupang, 85351, Indonesia; Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr, Sardjito General Hospital, Yogyakarta, 55281, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, 10430, Indonesia |
Scheffler, C., Institute of Biochemistry and Biology, Human Biology, University of Potsdam, Potsdam, 14469, Germany; Hermanussen, M., University of Kiel, Aschauhof, Eckernförde-Altenhof, 24340, Germany; Soegianto, S.D.P., Indonesian Pediatric Society, East Nusa Tenggara Branch, Kupang-East Nusa Tenggara, Kupang, 85351, Indonesia; Homalessy, A.V., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Touw, S.Y., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Angi, S.I., DDS PPDGS Konservasi Gigi FKG UGM, Jl. Sekip Utara, Sumatra, Medan, 20153, Indonesia; Ariyani, Q.S., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Suryanto, T., Indonesian Pediatric Society, East Nusa Tenggara Branch, Kupang-East Nusa Tenggara, Kupang, 85351, Indonesia; Matulessy, G.K.I., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Fransiskus, T., Indonesian Pediatric Society, East Nusa Tenggara Branch, Kupang-East Nusa Tenggara, Kupang, 85351, Indonesia; Safira, A.V.C., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Puteri, M.N., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Rahmani, R., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Ndaparoka, D.N., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Payong, M.K.E., Indonesian Medical Association Branch, Kupang, 85351, Indonesia; Indrajati, Y.D., DDS PPDGS Konservasi Gigi FKG UGM, Jl. Sekip Utara, Sumatra, Medan, 20153, Indonesia; Purba, R.K.H., Faculty of Medicine, Nusa Cendana University, Kupang, 85351, Indonesia; Manubulu, R.M., Indonesian Pediatric Society, East Nusa Tenggara Branch, Kupang-East Nusa Tenggara, Kupang, 85351, Indonesia; Julia, M., Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada-Dr, Sardjito General Hospital, Yogyakarta, 55281, Indonesia; Pulungan, A.B., Department of Child Health, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, 10430, Indonesia |
Socially, economically, politically and emotionally (SEPE) disadvantaged children are shorter than children from affluent background. In view of previous work on the lack of association between nutrition and child growth, we performed a study in urban schoolchildren. We measured 723 children (5.83 to 13.83 years); Kupang, Indonesia; three schools with different social back-ground. We investigated anthropometric data, clinical signs of malnutrition, physical fitness, parental education, and household equipment. Subjective self-confidence was assessed by the MacArthur test. The prevalence of stunting was between 8.5% and 46.8%. Clinical signs of under-or malnutrition were absent even in the most underprivileged children. There was no delay in tooth erup-tion. Underprivileged children are physically fitter than the wealthy. The correlation between height and state of nutrition (BMI_SDS, skinfold_SDS, MUAC_SDS) ranged between r = 0.69 (p < 0.01) and r = 0.43 (p < 0.01) in private school children, and between r = 0.07 (ns) and r = 0.32 (p < 0.01) in the underprivileged children. Maternal education interacted with height in affluent (r = 0.20, p < 0.01) and in underprivileged children (r = 0.20, p < 0.01). The shortness of SEPE disadvantaged children was not associated with anthropometric and clinical signs of malnutrition, nor with delay in physical development. Stunting is a complex phenomenon and may be considered a synonym of social disadvantage and poor parental education. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Economic; Political and emotional factors on growth; Social; Stunting |
child; cross-sectional study; growth disorder; human; Indonesia; malnutrition; nutritional status; prevalence; Child; Cross-Sectional Studies; Growth Disorders; Humans; Indonesia; Malnutrition; Nutritional Status; Prevalence |
MDPI AG |
16617827 |
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33540885 |
Article |
Q2 |
747 |
6560 |
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585 |
Silitonga P., Bustamam A., Muradi H., Mangunwardoyo W., Dewi B.E. |
57219406661;36815737800;57188977950;24544449900;24076058600; |
Comparison of dengue predictive models developed using artificial neural network and discriminant analysis with small dataset |
2021 |
Applied Sciences (Switzerland) |
11 |
3 |
943 |
1 |
16 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099695109&doi=10.3390%2fapp11030943&partnerID=40&md5=3a9bba4cf9ba9dacfef04d7349c81f4b |
Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Department of Mathematics, Faculty of Science and Information Technology, Institut Sains dan Teknologi Nasional, Jl.Moh Kahfi II Srengseng Sawah Jagakarsa, Jakarta Selatan, 12640, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 5, Kota Jakarta Pusat, Daerah Khusus Ibu Kota Jakarta, 10430, Indonesia |
Silitonga, P., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Muradi, H., Department of Mathematics, Faculty of Science and Information Technology, Institut Sains dan Teknologi Nasional, Jl.Moh Kahfi II Srengseng Sawah Jagakarsa, Jakarta Selatan, 12640, Indonesia; Mangunwardoyo, W., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Indonesia, Kampus Baru UI, Depok, 16424, Indonesia; Dewi, B.E., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya no. 5, Kota Jakarta Pusat, Daerah Khusus Ibu Kota Jakarta, 10430, Indonesia |
In Indonesia, dengue has become one of the hyperendemic diseases. Dengue consists of three clinical phases—febrile phase, critical phase, and recovery phase. Many patients have died in the critical phase due to the lack of proper and timely treatment. Therefore, we developed models that can predict the severity level of dengue based on the laboratory test results of the corresponding patients using Artificial Neural Network (ANN) and Discriminant Analysis (DA). In developing the models, we used a very small dataset. It is shown that ANN models developed using logistic and hyperbolic tangent activation function with 70% training data yielded the highest accuracy (90.91%), sensitivity (91.11%), and specificity (95.51%). This is the proposed model in this research. The proposed model will be able to help physicians in predicting the severity level of dengue patients before entering the critical phase. Furthermore, it will ease physicians in treating dengue patients early, so fatal cases or deaths can be avoided. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Artificial neural network; Dengue; Discriminant analysis |
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MDPI AG |
20763417 |
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Article |
Q2 |
435 |
11324 |
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634 |
Fachrucha F., Andarini S., Elhidsi M., Irawan R.Y., Beginta R., Sutoyo D.K. |
57224454767;8716259500;57203157152;57224450720;57428288200;6506079672; |
Pulmonary alveolar proteinosis with secondary Aspergillus infection: A case report |
2021 |
Journal of Health Sciences |
11 |
3 |
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191 |
195 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123527299&doi=10.17532%2fJHSCI.2021.1366&partnerID=40&md5=7d23bb20bec93b3f95d06cf257dca574 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Fachrucha, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Andarini, S., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Irawan, R.Y., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Beginta, R., Department of Anatomic Pathology, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sutoyo, D.K., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Pulmonary alveolar proteinosis (PAP) is a rare disease with mostly due to autoimmune toward granulocyte-macropahge colony-stimulating factor. In some conditions, PAP followed with secondary infection. A 34-year-old woman came with progressive shortness of breath, chronic dry cough, and mild fever. The chest High-Resolution Computed Tomography showed ground-glass opacity with septal reticulation or known as the crazy-paving pattern, and a cavity on the upper lobe of the left lung. The patient underwent bronchoscopy for diagnostic and therapeutic measures and found milky appearance bronchoalveolar lavage fluid (BALF). The serum galactomannan came out positive. Fungal infection detected from the BALF culture, Aspergillus fumigatus, hence fulfilling the diagnosis of PAP with probable invasive pulmonary aspergillosis. The patient showed clinical improvement after undergoing whole lung lavage and given anti-fungal medications © 2022 Fachrucha, et al.; licensee University of Sarajevo - Faculty of Health Studies |
Fungal infection; Milky appearance bronchoalveolar lavage fluid; Pulmonary alveolar proteinosis; Whole lung lavage |
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University of Sarajevo - Faculty of Health Studies |
22327576 |
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Article |
Q4 |
112 |
28273 |
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659 |
Dewi S., Yulhasri Y., Mulyawan W. |
57192904541;57225180520;57192910410; |
The Impact of Intermittent Hypobaric Hypoxia Exposures on Triacylglycerol Synthesis in Rat Liver |
2021 |
Reports of Biochemistry and Molecular Biology |
10 |
3 |
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437 |
444 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120058392&partnerID=40&md5=0ff2179c774f4a9d0d0a1c462ec80dc4 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia |
Dewi, S., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mulyawan, W., Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia |
Background: In a hypoxic state, fatty acid breakdown reaction may be inhibited due to a lack of oxygen. It is likely that the fatty acids will be stored as triacylglycerol. The aim of this study was to analyse triacylglycerol synthesis in the liver after intermittent hypobaric hypoxia (HH) exposures. Methods: Samples are liver tissues from 25 male Wistar rats were divided into 5 groups: controlgroup (normoxia), group I (once HH exposure), group II (twice HH exposures), group III (three-times HH exposures) and group IV (four-times HH exposures). The triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ were measured in rat liver from each group.Results: We demonstrated that triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ is elevated in group I significantly compared to control group. In the intermittent HH groups (group II, III and IV), mRNA expression of HIF-1α and PPAR-γ tends to downregulate near to control group. However, the triacylglycerol level is still found increased in the intermittent HH exposures groups. Significant increasing of triacylglycerol level was found especially in group IV compared to control group.Conclusions: We conclude that intermittent HH exposures will increase the triacylglycerol level in rat liver, supported by the increasing of HIF-1α and PPAR-γ mRNA expression that act as transcription factor to promote triacylglycerol synthesis © 2021. Reports of Biochemistry & Molecular Biology. All Rights Reserved. |
HIF-1α; Hypoxia; Liver; PPAR-γ; Triacylglycerol |
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Varastegan Institute for Medical Sciences |
23223480 |
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Article |
Q3 |
467 |
10677 |
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687 |
Chandra R., Pudjiadi A.H., Dewi R. |
57299963800;18435202300;57190859324; |
Citrullinated Histone H3 Level as a Novel Biomarker in Pediatric Clinical Sepsis |
2021 |
Indonesian Biomedical Journal |
13 |
3 |
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316 |
323 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117346746&doi=10.18585%2finabj.v13i3.1597&partnerID=40&md5=18aa6f1cc8a9eaeff375d765e0215f81 |
Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia |
Chandra, R., Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia; Pudjiadi, A.H., Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia; Dewi, R., Department of Child Health, Cipto Mangunkusumo Hospital/Faculty of Medicine, Universitas Indonesia, Jl. Diponegoro No.71, Jakarta, Indonesia |
Background: Sepsis is still leading cause of death in critically ill children. Early recognition of sepsis and treatments are needed to reduce its mortality. The use of citrullinated Histone H3 (Cit-H3) as an early sepsis marker and outcome predictor has been validated in previous studies among adults. However, only one study in pediatric meningococcal sepsis was reported with contradictory results. This study aims to determine Cit-H3 levels in pediatric clinical sepsis and analyze its association with sepsis severity and survival rate. METHODS: A prospective observational cohort study involving 67 pediatric subjects clinically diagnosed sepsis was conducted. Cit-H3 levels, Pediatric Logistic Organ Dysfunction-2 (PELOD-2) score, and Pediatric Sequential Organ Failure Assessment (pSOFA) score were assessed at the time of diagnosis (0-hour) and 48 hours later. Pearson Correlation test was used to determine the correlation between Cit-H3 levels with PELOD-2 andpSOFA scores and receiver operating curve to find the cutoff of Cit-H3 levels on clinical sepsis patients. RESULTS: Among clinically sepsis patients, the median Cit-H3 level was 1,210 (800-32,160) ng/mL, with optimal cut-off point ≥1200 ng/mL (sensitivity 83.3% and specificity 75.7%) to discriminate sepsis. The median Cit-H3 levels at 0-hour were lower in survivor compared to non-survivor group (p=0.016). Cit-H3 level was able to predict mortality with optimal cut-off point ≥1,200 ng/mL, sensitivity 72.2% and specificity 57.1% (AUC of 69.2%; p=0.017). Using survival analysis, Cit-H3 was significantly associated with the mortality rate (p=0.023; hazard ratio of 3.45). CONCLUSION: Cit-H3 level could be potential to predict pediatric sepsis events and its outcome. © 2021 |
citrullinated histone H3; neutrophil extracellular traps; pediatric sepsis; PELOD-2 score; pSOFA score; survival |
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Prodia Education and Research Institute |
20853297 |
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Article |
Q4 |
160 |
22228 |
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