No records
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641 |
Rustamadji P., Wiyarta E., Bethania K.A. |
55321572200;57221521342;57226320454; |
CD44 Variant Exon 6 Isoform Expression as a Potential Predictor of Lymph Node Metastasis in Invasive Breast Carcinoma of No Special Type |
2021 |
International Journal of Breast Cancer |
2021 |
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1586367 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122178964&doi=10.1155%2f2021%2f1586367&partnerID=40&md5=d1d81f9245419dc6421070e419983e36 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Invasive breast carcinoma of no special type (IBC-NST) is the most widespread invasive carcinoma subtype causing primarily regional metastases of the lymphatic node (LNM). The capacity of CD44 variant exon 6 (CD44v6) expression as an LNM predictor biomarker in IBC-NST was explored. Methods. We conducted a cross-sectional research with 48 paraffin blocks containing IBC-NST primary tumors that were divided into two groups by LNM. The assessment has been carried out in terms of age, tumor size, tumor grade, lymphovascular invasion (LVI), and CD44v6 expression. The expression of CD44v6 was analyzed on the grounds of immunohistochemical (IHC) staining, while other data were taken from archives. Statistical analysis is carried out by univariate, multivariate, and AUROC. Results. CD44v6 exhibits a dominant expression in IBC-NST tumor cells. Univariate analysis revealed a significant association between CD44v6 and LNM status (p=0.001). Multiple logistic regression results showed that CD44v6 expression and LVI were significantly associated with LNM with OR 10.7 (95% CI: 2.43 to 47.08) and 6.22 (95% CI: 1.4 to 27.88), respectively. CD44v6 expression was able to discriminate against LNM with AUROC 0.863±0.053 (95% CI: 0.759 to 0.967) at the H-score cut-off 133.889 (75% sensitivity and 83.3% specificity). Conclusion. CD44v6 expression and LVI are potential predictors of LNM in IBC-NST. The H-score cut-off of the CD44v6 expression can also be used as a threshold for classification in further investigation. © 2021 Primariadewi Rustamadji et al. |
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Hindawi Limited |
20903170 |
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Article |
Q3 |
552 |
9149 |
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642 |
Soetisna T.W., Namretta L., Tirta E.S., Catur M.M.S.P., Ronidipta B., Tjubandi A. |
57214887740;57394531400;57221753958;57394432600;57394432700;57211055979; |
The importance of differentiating types of myxoma: a case report |
2021 |
Cor et Vasa |
63 |
6 |
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733 |
735 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122153861&doi=10.33678%2fCOR.2021.063&partnerID=40&md5=ece88060ac36e8ce762e466c1383e95a |
Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
Soetisna, T.W., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia; Namretta, L., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Tirta, E.S., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Catur, M.M.S.P., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Ronidipta, B., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia; Tjubandi, A., Department of Cardiothoracic and Vascular Surgery, National Cardiovascular Centre Harapan Kita, Jakarta, Indonesia, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Indonesia |
Myxoma shows unspecific symptoms similar to other cardiac disorders. Late resection of myxoma will worsen output such as congestive heart failure, cardiac arrhythmia, and cardiac embolism, causing sudden death. Early diagnosis and surgical excision of cardiac myxomas, especially with the villous surface, must be done as soon as possible. Additional diagnostic examination was needed to define types of myxoma for earlier treatment to prevent complications. We present a case of atrial myxoma which was diagnosed and treated earlier than the median time reviewed by the previous study. This paper focuses on the importance of early diagnosis and defining types of myxoma. © 2021, ČKS. |
Myxoma; Tumor; Villous surface |
adult; cardiopulmonary bypass; case report; clinical article; color Doppler flowmetry; dyspnea; early diagnosis; heart atrium myxoma; heart atrium septum defect; human; human tissue; male; middle aged; mitral valve regurgitation; physical examination; Review; sinus bradycardia; sternotomy; transthoracic echocardiography |
Czech Society of Cardiology Z.S |
00108650 |
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Review |
Q4 |
177 |
20889 |
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643 |
Bangun K., Halim J., Tania V. |
36902624600;57219398869;57394760300; |
Repair of Protruding Bilateral Cleft Lip and Palate With Staged Premaxilla Setback Osteotomy, Cheiloplasty, and Palatoplasty in Trisomy 17p Patient: A Review of Syndromic Clinical Characteristic |
2021 |
Cleft Palate-Craniofacial Journal |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122134129&doi=10.1177%2f10556656211069820&partnerID=40&md5=065c5cf3acef75c03e60e1e90acf33a2 |
Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia |
Bangun, K., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia; Halim, J., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia; Tania, V., Cleft and Craniofacial Center, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Faculty of Medicine Universitas Indonesia, Indonesia |
Objective : Chromosome 17 duplication is correlated with an increased risk of developmental delay, birth defects, and intellectual disability. Here, we reported a female patient with trisomy 17 on the whole short arm with bilateral complete cleft lip and palate (BCLP). This study will review the surgical strategies to reconstruct the protruding premaxillary segment, cleft lip, and palate in trisomy 17p patient. Case Presentation : The patient had heterozygous pathogenic duplication of chromosomal region chr17:526-18777088 on almost the entire short arm of chromosome 17. Beside the commonly found features of trisomy 17p, the patient also presented with BCLP with a prominent premaxillary portion. Premaxillary setback surgery was first performed concomitantly with cheiloplasty. The ostectomy was performed posterior to the vomero-premaxillary suture (VPS). The premaxilla was firmly adhered to the lateral segment and the viability of philtral flap was not compromised. Two-flap palatoplasty with modified intravelar veloplasty (IVV) was performed 4 months after. Conclusion : Successful positioning of the premaxilla segment, satisfactory lip aesthetics, and vital palatal flap was obtained from premaxillary setback, primary cheiloplasty, and subsequent palatoplasty in our trisomy 17p patient presenting with BLCP. Postoperative premaxillary stability and patency of the philtral and palatal flap were achieved. Longer follow-up is needed to evaluate the long-term effects of our surgical techniques on inhibition of midfacial growth. However, the benefits that the patient received from the surgery in improving feeding capacity and facial appearance early in life outweigh the cost of possible maxillary retrusion. © 2021, American Cleft Palate-Craniofacial Association. |
bilateral cleft lip and palate; premaxillary osteotomy; trisomy 17 |
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SAGE Publications Ltd |
10556656 |
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Review |
Q2 |
641 |
7859 |
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644 |
Immanuel S., Ginanjar E., Nurtyas F.I.P., Sukartini N., Yusra Y., Pasaribu M.M.B.R. |
12777341300;23472616600;57391656300;6505680329;57220998367;57391787700; |
The role of neutrophil lymphocyte ratio as a major adverse cardiac events predictor and its correlation with coronary severity in acute coronary syndrome patients with chronic kidney disease: A case control and cross-sectional study |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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1758 |
1763 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122018503&doi=10.3889%2foamjms.2021.7488&partnerID=40&md5=f88a00ee4d9113e8e49425b6276d9400 |
Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ginanjar, E., Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nurtyas, F.I.P., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sukartini, N., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pasaribu, M.M.B.R., Department of Clinical Pathology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Acute coronary syndrome (ACS) patients with chronic kidney disease (CKD) are known to have a higher risk of mortality compared to ACS patients without CKD. In ACS patients with CKD, chronic inflammation plays an important role in morphological and functional changes in endothelial cells, resulting in atherosclerosis acceleration associated with coronary severity that leads to an increase in major adverse cardiac events (MACE). AIM: Therefore, this study aims to determine the role of neutrophil lymphocyte ratio (NLR) as a predictor of MACE and its correlation with coronary severity in ACS patients with CKD. METHODS: The study was conducted at National General Hospital Cipto Mangunkusumo Jakarta, Indonesia in October to November 2019. We used quota sampling with two designs study. First, a nested case control study was conducted with a total of 59 ACS patients with CKD: 31 subjects who had experienced MACE as a case group and 28 subjects who had not experienced MACE as a control group. Second, a correlative study with a cross-sectional approach was undertaken. RESULTS: There was no significant difference or relationship between NLR and MACE (p > 0.05; OR = 2.16 [95% CI = 0.63–7.51]), also no correlation between NLR and coronary severity degree assessed using the Gensini score (r = 0.10; p = 0.474). CONCLUSION: NLR can not predict MACE in ACS patients with CKD nor be employed interchangeably with the Gensini score in assessing coronary severity in ACS patients with CKD. © 2021 Suzanna Immanuel, Eka Ginanjar, Fahrani Imanina Putri Nurtyas, Ninik Sukartini, Yusra Yusra, Merci Monica B. R. Pasaribu. |
Acute coronary syndrome; Chronic kidney disease; Major adverse cardiac events predictor; Neutrophil lymphocyte ratio |
beta 2 microglobulin; hemoglobin; acute coronary syndrome; adult; Article; basophil count; case control study; chronic kidney failure; controlled study; coronary angiography; cross-sectional study; diabetes mellitus; disease severity; dyslipidemia; eosinophil count; female; Gensini score; human; hypertension; leukocyte count; leukocyte differential count; lymphocyte count; major adverse cardiac event; major clinical study; male; middle aged; monocyte count; neutrophil count; neutrophil lymphocyte ratio; non ST segment elevation myocardial infarction; platelet count; prediction; ST segment elevation myocardial infarction |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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645 |
Kusmardi K., Azzahra Baihaqi L., Estuningtyas A., Sahar N., Sunaryo H., Tedjo A. |
56966625300;57383198200;55650360200;57212464367;57214674652;57189320451; |
Ethanol Extract of Pomegranate (Punica granatum) Peel in Increasing the Expression of Caspase-3 in DSS-Induced Mice |
2021 |
International Journal of Inflammation |
2021 |
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4919410 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121616606&doi=10.1155%2f2021%2f4919410&partnerID=40&md5=f0575e8e8aafbe4434f9cad30aeabaca |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia; Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia, Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Human Cancer Research Center (HCRC Cluster, IMERI, Faculty of Medicine), Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Azzahra Baihaqi, L., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sahar, N., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sunaryo, H., Faculty of Pharmacy and Sciences, Universitas Muhammadiyah Prof. HAMKA, Jakarta, Indonesia; Tedjo, A., Drug Development Research Center (DDRC Cluster, IMERI, Faculty of Medicine), Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Background. Colorectal cancer (CRC) is a malignancy derived from the glandular epithelial cells in the colon. Patients with inflammatory bowel disease (IBD) are more likely to develop CRC. Cancer proliferation is characterized by the loss of inhibition of apoptosis, which involves caspase-3 activation. This study examined the effects of the pomegranate peel extract on the expression of caspase-3 in mice crypt cells induced by dextran sodium sulfate (DSS) 2%. Methods. The experimental study was done in six groups. All treatments were done in 42 days. The groups were all induced by DSS through water drinking, except for the normal group, which was only given water. The treatments given included the pomegranate extract in two doses (240 mg and 480 mg/kg bw/day), aspirin, and ellagic acid. The specimens were then fixated and stained for the immunohistochemistry scoring for the expression of caspase-3, which was then analyzed statistically. Results. The H-scores of each treatment group were 213.23 ± 8.32 (DSS group), 243.81 ± 18.69 (normal group), 226.10 ± 12.38 (pomegranate peel extract of 240 mg/kg/d), 238.84 ± 15.81 (pomegranate peel extract of 480 mg/kg/d), 227.47 ± 12.15 (aspirin), and 224.01 ± 18.39 (ellagic acid). Statistical differences were found in one-way analysis of variance (ANOVA) and post hoc analysis among the DSS group, normal group, and dose 2 group (pomegranate peel extract of 480 mg/kg/day). Conclusions. The ethanol extract of pomegranate was able to induce apoptosis, which was demonstrated by the increase of caspase-3 expression. © 2021 Kusmardi Kusmardi et al. |
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Hindawi Limited |
20908040 |
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Article |
Q2 |
1106 |
3761 |
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646 |
Pudjiadi A.H., Rahayu T., Wijaya S., Alatas F.S. |
18435202300;57382984100;56685332700;57217150164; |
Serum NT-Pro-BNP versus Noninvasive Bedside Inotropic Index in Paediatric Shock: A Contest of Myocardial Performance in Response to Fluid Loading |
2021 |
Critical Care Research and Practice |
2021 |
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7458186 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121597881&doi=10.1155%2f2021%2f7458186&partnerID=40&md5=9e069c0f9739bfd24a6994aa20089bfc |
Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Pasar Rebo Regional General Hospital, Jakarta, Indonesia |
Pudjiadi, A.H., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Rahayu, T., Pasar Rebo Regional General Hospital, Jakarta, Indonesia; Wijaya, S., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia; Alatas, F.S., Department of Child Health Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Kota Depok, Indonesia |
Background. Mild elevation of serum amino-terminal pro-B-type natriuretic peptide (NT-pro-BNP) is associated with myocardial dysfunction. A significantly lower Smith-Madigan inotropic index (SMII) has been shown to accurately represent cardiac contractility among heart failure subjects. We aim to monitor the effect of fluid resuscitation on cardiac function among paediatric patients by measuring serum NT-pro-BNP and SMII. Methods. This is an observational study on 70 paediatric shock patients. NT-pro-BNP and noninvasive bedside haemodynamic monitoring were done by using an ultrasonic cardiac output monitor (USCOM, USCOM, Sydney, Australia). The presence of cardiac diseases was excluded. SMII was obtained from the USCOM. An increase in the stroke volume index (SVI) of ≥15% indicates fluid responders. Measurements were taken before and after fluid loading. Results. Preloading NT-pro-BNP and SMII category were significantly different between the fluid responsiveness group, p=0.001 and p=0.004, respectively. Higher median NT-pro-BNP (preloading NT-pro-BNP of 1175.00 (254.50-9965.00) ng/mL vs. 196.00 (65.00-509.00) ng/mL, p=0.002) was associated with fluid nonresponders (subjects >12 months old). Preloading NT-pro-BNP <242.5 ng/mL was associated with fluid responders (AUC: 0.768 (0.615-0.921), p=0.003), 82.1% sensitivity, and 68.7% specificity for subjects >12 years old. Delta NT-pro-BNP in fluid responders (15.00 (-16.00-950.00) ng/mL) did not differ from fluid nonresponders (505.00 (-797.00-1600.00) ng/mL), p=0.456. Postloading SMII >1.25 W·m-2 was associated with fluid responders (AUC: 0.683 (0.553-0.813), p = 0.011), 61.9% sensitivity, and 66.7% specificity, but not preloading SMII. Fluid responders had a higher mean postloading SMII compared to nonresponders (1.36 ± 0.38 vs. 1.10 ± 0.34, p=0.006). Conclusion. Higher NT-pro-BNP and lower SMII in the absence of cardiac diseases were associated with poor response to fluid loading. The SMII is affected by low preload conditions. © 2021 Antonius Hocky Pudjiadi et al. |
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Hindawi Limited |
20901305 |
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Article |
Q2 |
532 |
9497 |
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647 |
Carragher N., Billieux J., Bowden-Jones H., Achab S., Potenza M.N., Rumpf H.-J., Long J., Demetrovics Z., Gentile D., Hodgins D., Aricak O.T., Baigent M., Gandin C., Rahimi-Movaghar A., Scafato E., Assanangkornchai S., Siste K., Hao W., King D.L., Saunders J., Higuchi S., Poznyak V. |
24467456900;57220421868;15834239200;43860942100;7006591634;7004528536;57190689045;55882733400;7004297104;7006685175;22033598100;6602225637;7004229411;8696686900;55644049900;6603003749;55644113100;57226152467;57214845145;7402341830;57383866600;57206524465; |
Brief overview of the WHO Collaborative Project on the Development of New International Screening and Diagnostic Instruments for Gaming Disorder and Gambling Disorder |
2021 |
Addiction |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121573160&doi=10.1111%2fadd.15780&partnerID=40&md5=e4d9f85cf6d05ef0bbd42cad79ab7617 |
Alcohol, Drugs and Addictive Behaviours Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland; National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia; Institute of Psychology, University of Lausanne, Lausanne, Switzerland; Centre for Excessive Gambling, Addiction Medicine, Lausanne University Hospitals (CHUV), Lausanne, Switzerland; National Problem Gambling Clinic; National Centre for Gaming Disorders, United Kingdom; Faculty of Brain Sciences, University College London, London, United Kingdom; WHO Collaborating Centre in Research and Training in Mental Health, Faculty of Medicine, University of Geneva, Geneva, 1202, Switzerland; Treatment Facility for Addictive Behaviors, Department of Psychiatry, University Hospitals of Geneva, Switzerland; Department of Psychiatry and Neuroscience, Child Study Center, School of Medicine, Yale University, New Haven, CT, United States; Department of Psychiatry and Psychotherapy, University of Lübeck, Germany; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China; Psychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Centre of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar; Addiction Research Group, ELTE Eötvös Loránd University, Budapest, Hungary; Department of Psychology, Iowa State University, Ames, IA, United States; Department of Psychology, University of Calgary, Calgary, Canada; Hasan Kalyoncu University, Gaziantep, Turkey; Turkish Green Crescent Society, Istanbul, Turkey; Department of Psychiatry, College of Medicine and Public Health, Flinders University, Adelaide, Australia; Statewide Gambling Therapy Service, Flinders Medical Centre, Bedford Park, Australia; National Observatory on Alcohol, National Institute of Health, Rome, Italy; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand; Department of Psychiatry, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mental Health Institute of the Second Xiangya Hospital, Central South University, China; Consortium on Clinical bigdata and Biobank for Addiction Research (3CBAR), Changsha, Hunan, China; College of Education, Psychology, and Social Work, Flinders University, Australia; Department of Public Health Sciences, University of Connecticut School of Medicine, University of Queensland, Australia; National Hospital Organization Kurihama Medical and Addiction Center, Japan |
Carragher, N., Alcohol, Drugs and Addictive Behaviours Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland, National Drug and Alcohol Research Centre, University of New South Wales, Sydney, Australia; Billieux, J., Institute of Psychology, University of Lausanne, Lausanne, Switzerland, Centre for Excessive Gambling, Addiction Medicine, Lausanne University Hospitals (CHUV), Lausanne, Switzerland; Bowden-Jones, H., National Problem Gambling Clinic; National Centre for Gaming Disorders, United Kingdom, Faculty of Brain Sciences, University College London, London, United Kingdom; Achab, S., WHO Collaborating Centre in Research and Training in Mental Health, Faculty of Medicine, University of Geneva, Geneva, 1202, Switzerland, Treatment Facility for Addictive Behaviors, Department of Psychiatry, University Hospitals of Geneva, Switzerland; Potenza, M.N., Department of Psychiatry and Neuroscience, Child Study Center, School of Medicine, Yale University, New Haven, CT, United States; Rumpf, H.-J., Department of Psychiatry and Psychotherapy, University of Lübeck, Germany; Long, J., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, China, Psychological Science Research Institute, Université Catholique de Louvain, Louvain-la-Neuve, Belgium; Demetrovics, Z., Centre of Excellence in Responsible Gaming, University of Gibraltar, Gibraltar, Addiction Research Group, ELTE Eötvös Loránd University, Budapest, Hungary; Gentile, D., Department of Psychology, Iowa State University, Ames, IA, United States; Hodgins, D., Department of Psychology, University of Calgary, Calgary, Canada; Aricak, O.T., Hasan Kalyoncu University, Gaziantep, Turkey, Turkish Green Crescent Society, Istanbul, Turkey; Baigent, M., Department of Psychiatry, College of Medicine and Public Health, Flinders University, Adelaide, Australia, Statewide Gambling Therapy Service, Flinders Medical Centre, Bedford Park, Australia; Gandin, C., National Observatory on Alcohol, National Institute of Health, Rome, Italy; Rahimi-Movaghar, A., Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Scafato, E., National Observatory on Alcohol, National Institute of Health, Rome, Italy; Assanangkornchai, S., Department of Epidemiology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand; Siste, K., Department of Psychiatry, Faculty of Medicine Universitas Indonesia, dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hao, W., Mental Health Institute of the Second Xiangya Hospital, Central South University, China, Consortium on Clinical bigdata and Biobank for Addiction Research (3CBAR), Changsha, Hunan, China; King, D.L., College of Education, Psychology, and Social Work, Flinders University, Australia; Saunders, J., Department of Public Health Sciences, University of Connecticut School of Medicine, University of Queensland, Australia; Higuchi, S., National Hospital Organization Kurihama Medical and Addiction Center, Japan; Poznyak, V., Alcohol, Drugs and Addictive Behaviours Unit, Department of Mental Health and Substance Use, World Health Organization, Geneva, Switzerland |
[No abstract available] |
Addictive behaviours; assessment; diagnosis; gambling; gaming; screening; video games; WHO |
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John Wiley and Sons Inc |
09652140 |
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Letter |
Q1 |
2424 |
961 |
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648 |
Sungkar A. |
55110453800; |
Preterm birth in low-resource setting |
2021 |
Donald School Journal of Ultrasound in Obstetrics and Gynecology |
15 |
2 |
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175 |
178 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121540929&doi=10.5005%2fjp-journals-10009-1695&partnerID=40&md5=6bdfb4b0abc69737097e5332647cdcc6 |
Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Sungkar, A., Fetomaternal Division, Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Preterm labor (PTL) is a global problem which is a complex disease with a high rate of morbidity and mortality, also has long-term consequences for the baby and the family. The well-known morbidities related to PTL are respiratory distress syndrome, necrotizing enterocolitis, intraventricular hemorrhage, retinopathy of prematurity, and anemia of prematurity. In a developing country, the management of PTL is limited by poor health systems, low education level of the mother, poor financial support, lack of facility and trained health personnel, and demographic barriers. This limitation leads to high morbidity and mortality of preterm birth, especially in developing countries. It is important to reduce the rate of preterm birth by preventing the event. Several risk factors have been identified and are avoidable and preventable, such as smoking, bacterial infection, poor nutritional status, and malnourished mothers. Strategies to prevent PTL have been proposed in primary, secondary, and tertiary interventions to reduce the morbidity and mortality of preterm birth. © Jaypee Brothers Medical Publishers. 2021. |
Management; Morbidity and mortality; Preterm labor; Risk factor |
fibronectin; folic acid; homocysteine; iron; trace element; zinc; allergy; body mass; cigarette smoking; early diagnosis; endocrine disease; gestational weight gain; graft rejection; human; hyperhomocysteinemia; hypertension; infertility therapy; intrauterine growth retardation; intrauterine infection; ischemia; macronutrient; morbidity; mortality; multiple pregnancy; non communicable disease; nutritional deficiency; preeclampsia; pregnancy diabetes mellitus; premature labor; prepregnancy care; Review; risk factor; transvaginal echography; uterine cervix carcinoma in situ; uterine cervix incompetence; vascular disease |
Jaypee Brothers Medical Publishers (P) Ltd |
0973614X |
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Review |
Q4 |
162 |
22036 |
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649 |
Mukti A.I., Ilyas S., Warli S.M., Putra A., Rasyid N., Munir D., Siregar K.B., Ichwan M., Alif I., Hidayah N. |
57376899500;55980597400;57189610001;57197818079;56245069300;57039203600;57190863373;26040779000;57215218352;57377826800; |
Mesenchymal stem cells enhance vascular endothelial growth factor-A, endothelial nitric oxide synthetase, and HSP70 expression in improving erectile dysfunction in streptozotocin-induced diabetic rats |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1174 |
1180 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121417031&doi=10.3889%2foamjms.2021.7801&partnerID=40&md5=d2741187724b6c10a2d9b17fcabd3aad |
Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Department of Urology, Faculty of Medicine, Universitas Sumatera Utara Hospital, Medan, Indonesia; Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia; Department of Pathology, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Department of Postgraduate Biomedical Science, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Pusat Unggulan IPTEK Tissue Engineering, Universitas Sumatera Utara, Medan, Indonesia; Department of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia |
Mukti, A.I., Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Ilyas, S., Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Sumatera Utara, Medan, Indonesia; Warli, S.M., Department of Urology, Faculty of Medicine, Universitas Sumatera Utara Hospital, Medan, Indonesia; Putra, A., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia, Department of Pathology, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia, Department of Postgraduate Biomedical Science, Medical Faculty, Sultan Agung Islamic University, Semarang, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Munir, D., Department of Doctoral Degree Program, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia, Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia, Pusat Unggulan IPTEK Tissue Engineering, Universitas Sumatera Utara, Medan, Indonesia; Siregar, K.B., Department of Oncology Surgery, Faculty of Medicine, Universitas Sumatera Utara, Universitas Sumatera Utara Hospital, Medan, Indonesia; Ichwan, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Sumatera Utara, Medan, Indonesia; Alif, I., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia; Hidayah, N., Stem Cell and Cancer Research, Faculty of Medical, Sultan Agung Islamic University, Semarang, Indonesia |
AIM: This study investigated the therapeutic role of mesenchymal stem cells (MSCs) on erectile function in a diabetes mellitus erectile dysfunction (DMED) rat model by analyzing the expression of endothelial nitric oxide synthetase (eNOS), vascular endothelial growth factor A (VEGF-A), and the 70 kilodalton heat shock proteins (HSP70). METHODS: MSCs were isolated from umbilical cords (UCs), and their characteristics identified by flow cytometry and osteogenic differentiation analysis. Thirty 8-week-old rats were divided into four groups: Sham, control, T1, and T2. After a 16 h fast, 24 rats were randomly selected and intraperitoneally injected with streptozotocin (STZ) to induce diabetes mellitus. At 8 weeks after STZ injection, rats with DMED were classified into four groups, sham, control group (DMED rats received 500 μL phosphate buffer saline [PBS]); T1 (DMED rats treated with 500 μL PBS containing 1 × 106 UC-MSCs); and T2 (DMED rats treated with 500 μL PBS containing 2 × 106 UC-MSCs). Eight weeks after MSCs administration, the rats’ erectile function was measured by cavernous nerve stimulation. The blinded histological and gene expression assessment were used to analyze the eNOS, HSP70 content, and VEGF-A expression on the penile tissues. RESULTS: MSCs administration, rats in T1 and T2 groups showed a significant enhancement of erectile response that showed a trend of increase of VEGF-A mRNA level expression was 2.2 ± 0.61 in T2 Group supported with the optimum recovery of eNOS, in which the value of eNOS expression was 20.66% ± 2.32%. While optimum decrease of HSP70 content, the value of HSP70 expression was 15.50% ± 0.90%. IHC results showed that the DMED induction in rats caused a significant decrease of eNOS content in corpus cavernosum tissue. CONCLUSION: MSCs could ameliorate DMED in rats by increasing VEGF-A and decreasing HSP70 and eNOS, indicating these cells offer a potential application for DMED patients’ treatment. © 2021 Ade Indra Mukti, Syafruddin Ilyas, Syah Mirsya Warli, Agung Putra, Nur Rasyid, Delfitri Munir, Kamal Basri Siregar, Muhammad Ichwan, Iffan Alif, Nurul Hidayah. |
Endothelial nitric oxide synthetase; Erectile dysfunction; HSP70; Mesenchymal stem cells; Vascular endothelial growth factor A-A |
heat shock protein; heat shock protein 70; messenger RNA; nitric oxide synthase; vasculotropin A; animal cell; animal experiment; animal model; animal tissue; Article; cell differentiation; controlled study; corpus cavernosum; erectile dysfunction; female; flow cytometry; gene expression; glucose blood level; histology; hypoglycemia; immunohistochemistry; International Index of Erectile Function; lipid storage; male; mesenchymal stem cell; nerve stimulation; nonhuman; polymerase chain reaction; protein expression; rat; real time polymerase chain reaction; Sertoli cell; streptozotocin-induced diabetes mellitus |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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650 |
Jufri M., Vardhani A., Purwaningsih E. |
55542805100;57372533300;57186723500; |
Evaluating the efficacy of lotion containing black rice bran (Oryza sativa L. indica) extract as skin brightening agent: A clinical trial |
2021 |
Jundishapur Journal of Natural Pharmaceutical Products |
16 |
4 |
e114152 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121121214&doi=10.5812%2fjjnpp.114152&partnerID=40&md5=7475812ecd399617effa3198e4bc8700 |
Faculty of Pharmacy, Universitas Indonesia, Indonesia; Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Indonesia |
Jufri, M., Faculty of Pharmacy, Universitas Indonesia, Indonesia; Vardhani, A., Faculty of Pharmacy, Universitas Indonesia, Indonesia; Purwaningsih, E., Department of Pharmacy, Faculty of Medicine, Universitas Indonesia, Indonesia |
Background: Ultraviolet exposure is an extrinsic factor to initiate melanogenesis, the process of melanin formation in the skin. Nowadays, natural ingredients tend to be more prevalent in cosmetic formulations due to consumers’ concern about synthetic ingredients and the risks they may represent for human health. Rice bran, the outer layer of a rice grain, can be utilized as a skin-lightening agent. Objectives: This study aimed to determine the efficacy of a lotion containing black rice bran (Oryza sativa L. indica) ethanolic extract as a skin lightening agent. Methods: The black rice bran ethanolic extract was formulated into oil in water (o/w) lotion. In this study, 34 women applied the lotion at one side of the forearm and base placebo lotion as control at the other side of forearm. The results were tested with a paired t-test by GraphPad Prism 8.3.0 software. Results: There was a significant decrease in the melanin index and erythema index in the forearm with a lotion containing black rice bran extract (P-value < 0.0001). Conclusions: The lotion containing 10% black rice bran extract was effective as a skin lightener because it effectively reduced skin melanin production when applied topically. Copyright © 2021, Author(s). |
Black Rice Bran; Clinical Trials; Natural Product; Oryza sativa L. indica; Skin Lightening Agent |
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Kowsar Medical Institute |
17357780 |
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Article |
Q3 |
228 |
17746 |
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