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527 |
Supali T., Djuardi Y., Christian M., Iskandar E., Alfian R., Maylasari R., Destani Y., Lomiga A., Minggu D., Lew D., Bogus J., Weil G.J., Fischer P.U. |
6602742029;6507800820;57209806543;57202299885;57222748640;57222744651;57222743128;57205724071;57202307524;57196371851;57170558700;7007028568;23567680200; |
An open label, randomized clinical trial to compare the tolerability and efficacy of ivermectin plus diethylcarbamazine and albendazole vs. Diethylcarbamazine plus albendazole for treatment of brugian filariasis in Indonesia |
2021 |
PLoS Neglected Tropical Diseases |
15 |
3 |
e0009294 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103946402&doi=10.1371%2fjournal.pntd.0009294&partnerID=40&md5=bf67e831adfbad446acbda06b08e12de |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Nusa Cendana, Kupang, Lasiana, Kelapa lima, Kota Kupang, Indonesia; Nusa Tenggara Timur Provincial Health Office, Oebobo, Kota Kupang, Nusa Tenggara Timur, Indonesia; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, United States; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States |
Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djuardi, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Christian, M., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iskandar, E., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alfian, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Maylasari, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Destani, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lomiga, A., Universitas Nusa Cendana, Kupang, Lasiana, Kelapa lima, Kota Kupang, Indonesia; Minggu, D., Nusa Tenggara Timur Provincial Health Office, Oebobo, Kota Kupang, Nusa Tenggara Timur, Indonesia; Lew, D., Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, United States; Bogus, J., Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Weil, G.J., Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Fischer, P.U., Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States |
Improved treatments for lymphatic filariasis (LF) could accelerate the global elimination program for this disease. A triple drug combination of the anti-filarial drugs ivermectin, diethyl-carbamazine (DEC) and albendazole (IDA) has been shown to be safe and effective for achieving sustained clearance of microfilariae (Mf) of the filarial parasite Wuchereria ban-crofti from human blood. However, the triple drug combination has not been previously been evaluated for treatment of brugian filariasis, which accounts for about 10% of the global LF burden. This hospital-based clinical trial compared the safety and efficacy of IDA with that of the standard treatment (DEC plus albendazole, DA) in persons with Brugia timori infections on Sumba island, Indonesia. Fifty-five asymptomatic persons with B. timori Mf were treated with either a single oral dose of IDA (28 subjects) or with DEC plus albendazole (DA, 27 sub-jects). Participants were actively monitored for adverse events (AE) for two days after treatment by nurses and physicians who were masked regarding treatment assignments. Passive monitoring was performed by clinical teams that visited participant’s home villages for an additional five days. Microfilaremia was assessed by membrane filtration of 1 ml night blood at baseline, at 24h and one year after treatment. IDA was more effective than DA for completely clearing Mf at 24 hours (25/28, 89% vs. 8/27, 30%, P < 0.001). By 12 months after treatment, only one of 27 IDA recipients had Mf in their blood (4%) vs. 10 of 25 (40%) in persons treated with DA (P = 0.002). Approximately 90% of participants had antibodies to recombinant filarial antigen BmR1 at baseline. Antibody prevalence decreased to approximately 30% in both treatment groups at 12 months. About 45% of persons in both treatment groups experienced AE such as fever, muscle aches, lower back, joint and abdominal pain. These were mostly mild and most common during the first two days after treatment. No participant experienced a severe or serious AE. This study showed that IDA was well-tolerated and significantly more effective for clearing B. timori Mf from the blood than DA. Larger studies should be performed to further assess the safety and efficacy of IDA as a mass drug administration regimen to eliminate brugian filariasis. © 2021 Supali et al. |
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albendazole; antifilarial agent; diethylcarbamazine; immunoglobulin G4; ivermectin; albendazole; antifilarial agent; diethylcarbamazine; ivermectin; protozoon antibody; abdominal pain; adult; antibody titer; arthralgia; Article; body mass; Brugia; Brugian filariasis; Burkholderia pseudomallei; combination drug therapy; controlled study; coughing; daily life activity; double blind procedure; dried blood spot testing; drowsiness; drug efficacy; drug safety; drug tolerability; female; fever; filariasis; follow up; gametocyte; headache; helminthiasis; human; Indonesia; leprosy; low back pain; lymphatic filariasis; major clinical study; male; mass drug administration; microfilariasis; myalgia; pharmacokinetics; Plasmodium falciparum; prevalence; questionnaire; randomized controlled trial; Schis |
Public Library of Science |
19352727 |
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33780481 |
Article |
Q1 |
1990 |
1322 |
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530 |
Armas Rojas N.B., Lacey B., Simadibrata D.M., Ross S., Varona-Pérez P., Burrett J.A., Calderón Martínez M., Lorenzo-Vázquez E., Bess Constantén S., Thomson B., Sherliker P., Morales Rigau J.M., Carter J., Massa M.S., Hernández López O.J., Islam N., Martínez Morales M.Á., Alonso Alomá I., Achiong Estupiñan F., Díaz González M., Rosquete Muñoz N., Cendra Asencio M., Emberson J., Peto R., Lewington S. |
25122220300;7004338442;57202134322;57222402777;6508209690;18833958600;56323463600;57188694725;57205675816;57194423183;6507011848;35520243600;57203543175;26649987700;57205676718;57217501333;36802068200;57205671350;57205675732;57205677327;57205673279;57205673929;6701688192;34572276000;6601929863; |
Alcohol consumption and cause-specific mortality in Cuba: prospective study of 120 623 adults |
2021 |
EClinicalMedicine |
33 |
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100692 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102626908&doi=10.1016%2fj.eclinm.2020.100692&partnerID=40&md5=379be44a40d2f0b3e189516f974772f4 |
National Institute of Cardiology and Cardiovascular Surgery, Havana, Cuba; Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Institute of Hygiene, Epidemiology and Microbiology, Ministry of Public Health, Havana, Cuba; Cuban Commission Against Smoking, Ministry of Public Health, Havana, Cuba; Directorate of Medical Records and Health Statistics, Ministry of Public Health, Havana, Cuba; George Institute for Global Health, University of Oxford, United Kingdom; MRC Population Heath Research Unit, NDPH, University of Oxford, United Kingdom; Provincial Center of Hygiene, Epidemiology and Microbiology, Matanzas, Cuba; Municipal Center of Hygiene, Epidemiology and Microbiology, Jagüey Grande, Matanzas, Cuba; Municipal Center of Hygiene, Epidemiology and Microbiology, ColónMatanzas, Cuba; Municipal Center of Hygiene, Epidemiology and Microbiology, Camagüey, Cuba; MRC UKM Medical Molecular Biology Institute (UMBI), NDPH, Malaysia |
Armas Rojas, N.B., National Institute of Cardiology and Cardiovascular Surgery, Havana, Cuba; Lacey, B., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Simadibrata, D.M., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ross, S., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Varona-Pérez, P., Institute of Hygiene, Epidemiology and Microbiology, Ministry of Public Health, Havana, Cuba; Burrett, J.A., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Calderón Martínez, M., Institute of Hygiene, Epidemiology and Microbiology, Ministry of Public Health, Havana, Cuba; Lorenzo-Vázquez, E., Cuban Commission Against Smoking, Ministry of Public Health, Havana, Cuba; Bess Constantén, S., Directorate of Medical Records and Health Statistics, Ministry of Public Health, Havana, Cuba; Thomson, B., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom, George Institute for Global Health, University of Oxford, United Kingdom; Sherliker, P., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom, MRC Population Heath Research Unit, NDPH, University of Oxford, United Kingdom; Morales Rigau, J.M., Provincial Center of Hygiene, Epidemiology and Microbiology, Matanzas, Cuba; Carter, J., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Massa, M.S., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Hernández López, O.J., Municipal Center of Hygiene, Epidemiology and Microbiology, Jagüey Grande, Matanzas, Cuba; Islam, N., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Martínez Morales, M.Á., Directorate of Medical Records and Health Statistics, Ministry of Public Health, Havana, Cuba; Alonso Alomá, I., Directorate of Medical Records and Health Statistics, Ministry of Public Health, Havana, Cuba; Achiong Estupiñan, F., Provincial Center of Hygiene, Epidemiology and Microbiology, Matanzas, Cuba; Díaz González, M., Municipal Center of Hygiene, Epidemiology and Microbiology, ColónMatanzas, Cuba; Rosquete Muñoz, N., Municipal Center of Hygiene, Epidemiology and Microbiology, Camagüey, Cuba; Cendra Asencio, M., Provincial Center of Hygiene, Epidemiology and Microbiology, Matanzas, Cuba; Emberson, J., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom, MRC Population Heath Research Unit, NDPH, University of Oxford, United Kingdom; Peto, R., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom; Lewington, S., Nuffield Department of Population Health (NDPH), University of Oxford, United Kingdom, MRC Population Heath Research Unit, NDPH, University of Oxford, United Kingdom, MRC UKM Medical Molecular Biology Institute (UMBI), NDPH, Malaysia |
Background: The associations of cause-specific mortality with alcohol consumption have been studied mainly in higher-income countries. We relate alcohol consumption to mortality in Cuba. Methods: In 1996-2002, 146 556 adults were recruited into a prospective study from the general population in five areas of Cuba. Participants were interviewed, measured and followed up by electronic linkage to national death registries until January 1, 2017. After excluding all with missing data or chronic disease at recruitment, Cox regression (adjusted for age, sex, province, education, and smoking) was used to relate mortality rate ratios (RRs) at ages 35–79 years to alcohol consumption. RRs were corrected for long-term variability in alcohol consumption using repeat measures among 20 593 participants resurveyed in 2006-08. Findings: After exclusions, there were 120 623 participants aged 35-79 years (mean age 52 [SD 12]; 67 694 [56%] women). At recruitment, 22 670 (43%) men and 9490 (14%) women were current alcohol drinkers, with 15 433 (29%) men and 3054 (5%) women drinking at least weekly; most alcohol consumption was from rum. All-cause mortality was positively and continuously associated with weekly alcohol consumption: each additional 35cl bottle of rum per week (110g of pure alcohol) was associated with ∼10% higher risk of all-cause mortality (RR 1.08 [95%CI 1.05-1.11]). The major causes of excess mortality in weekly drinkers were cancer, vascular disease, and external causes. Non-drinkers had ∼10% higher risk (RR 1.11 [1.09-1.14]) of all-cause mortality than those in the lowest category of weekly alcohol consumption (<1 bottle/week), but this association was almost completely attenuated on exclusion of early follow-up. Interpretation: In this large prospective study in Cuba, weekly alcohol consumption was continuously related to premature mortality. Reverse causality is likely to account for much of the apparent excess risk among non-drinkers. The findings support limits to alcohol consumption that are lower than present recommendations in Cuba. Funding: Medical Research Council, British Heart Foundation, Cancer Research UK, CDC Foundation (with support from Amgen) © 2021 The Authors |
Alcohol; Cuba; Mortality; Prospective study |
antihypertensive agent; adult; age distribution; aged; alcohol consumption; Article; body mass; controlled study; Cuba; diastolic blood pressure; evidence based medicine; female; follow up; health care policy; human; hypertension; ICD-10; ICD-9; major clinical study; male; mortality; mortality rate; premature mortality; prospective study; regression analysis; risk assessment; risk factor; sex difference; systolic blood pressure |
Lancet Publishing Group |
25895370 |
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Article |
Q1 |
1915 |
1435 |
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531 |
Lazarus G., Tjoa K., Iskandar A.W.B., Louisa M., Sagwa E.L., Padayatchi N., Soetikno V. |
57214599425;57222366705;57217632802;41461551400;53464303100;6603387290;36769252100; |
The effect of human immunodeficiency virus infection on adverse events during treatment of drug-resistant tuberculosis: A systematic review and meta-analysis |
2021 |
PLoS ONE |
16 |
3 March |
e0248017 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102483457&doi=10.1371%2fjournal.pone.0248017&partnerID=40&md5=e604a5ae346e4c3a4b38a5f906459a26 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Windhoek, Namibia; Nairobi, Kenya; CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa |
Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tjoa, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iskandar, A.W.B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sagwa, E.L., Windhoek, Namibia, Nairobi, Kenya; Padayatchi, N., CAPRISA MRC-HIV-TB Pathogenesis and Treatment Research Unit, Durban, South Africa; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background Adverse events (AEs) during drug-resistant tuberculosis (DR-TB) treatment, especially with human immunodeficiency virus (HIV) co-infection, remains a major threat to poor DR-TB treatment adherence and outcomes. This meta-analysis aims to investigate the effect of HIV infection on the development of AEs during DR-TB treatment. Methods Eligible studies evaluating the association between HIV seropositivity and risks of AE occurrence in DR-TB patients were included in this systematic review. Interventional and observational studies were assessed for risk of bias using the Risk of Bias in Nonrandomized Studies of Intervention and Newcastle-Ottawa Scale tool, respectively. Random-effects meta-analysis was performed to estimate the pooled risk ratio (RR) along with their 95% confidence intervals (CIs). Results A total of 37 studies involving 8657 patients were included in this systematic review. We discovered that HIV infection independently increased the risk of developing AEs in DR-TB patients by 12% (RR 1.12 [95% CI: 1.02-1.22]; I2 = 0%, p = 0.75). In particular, the risks were more accentuated in the development of hearing loss (RR 1.44 [95% CI: 1.18-1.75]; I2 = 60%), nephrotoxicity (RR 2.45 [95% CI: 1.20-4.98], I2 = 0%), and depression (RR 3.53 [95% CI: 1.38-9.03]; I2 = 0%). Although our findings indicated that the augmented risk was primarily driven by antiretroviral drug usage rather than HIV-related immunosuppression, further studies investigating their independent effects are required to confirm our findings. Conclusion HIV co-infection independently increased the risk of developing AEs during DR-TB treatment. Increased pharmacovigilance through routine assessments of audiological, renal, and mental functions are strongly encouraged to enable prompt diagnosis and treatment in patients experiencing AEs during concomitant DR-TB and HIV treatment. Copyright: © 2021 Lazarus et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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antiretrovirus agent; efavirenz; ethionamide; kanamycin; lamivudine; pyrazinamide; tenofovir; tuberculostatic agent; tuberculostatic agent; adverse event; antiretroviral therapy; coinfection; confidence interval; data analysis; data extraction; data quality assessment; depression; drug resistant tuberculosis; hearing impairment; human; Human immunodeficiency virus infection; immune deficiency; meta analysis; nephrotoxicity; Newcastle-Ottawa scale; Review; statistical analysis; systematic review; adverse drug reaction; complication; depression; hearing impairment; Human immunodeficiency virus infection; kidney failure; multidrug resistant tuberculosis; Antitubercular Agents; Depression; Drug-Related Side Effects and Adverse Reactions; Hearing Loss; HIV Infections; Humans; Renal Insufficienc |
Public Library of Science |
19326203 |
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33662024 |
Review |
Q1 |
990 |
4434 |
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533 |
Harzif A.K., Maidarti M., Ginanjar I., Shadrina A., Meutia A.P. |
57191493435;56320510400;57222277529;57195984988;57203368133; |
Vesicouterine fistula presenting with cyclical haematuria mimicking bladder endometriosis: A case report |
2021 |
International Journal of Surgery Case Reports |
80 |
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105709 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102104682&doi=10.1016%2fj.ijscr.2021.105709&partnerID=40&md5=a7cce7444d199f8f94c660f216a8bc66 |
Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Harzif, A.K., Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Maidarti, M., Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ginanjar, I., Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Shadrina, A., Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meutia, A.P., Department of Obstetrics and Gynecology, Faculty of Medicine University of Indonesia Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Vesicouterine fistula (VUF) is an abnormal communication between the bladder and uterus, occurring 1–4% of all urogenital fistulas. Diagnosis is still a challenge because symptoms may appear late or fistula may be missed even after repeated examination. A 37-year old woman who has two children born through caesarean section complained of the absence of menstruation for the past three years. At the same time point, she experienced cyclic haematuria and amenorrhea. The diagnosis was made through ultrasonography, cystoscopy and hysteroscopy. She was then managed with laparoscopic bladder fistula repair continued with total laparoscopic hysterectomy. The VUF can present as an undesirable consequence of caesarean section. © 2021 The Authors |
Case report; Cyclic hematuria; Secondary amenorrhea; Vesicocervical fistula |
contrast medium; adult; Article; bladder disease; bladder fistula; bladder injury; bladder neck; bladder trigone; case report; cesarean section; clinical article; contrast enhancement; cystoscopy; cystostomy; endometrial thickness; endometriosis; female; hematuria; human; hysterectomy; hysterosalpingography; hysteroscopy; laparoscopic surgery; postoperative period; premenstrual syndrome; priority journal; reconstructive surgery; secondary amenorrhea; transvaginal echography; urography; uterus disease; vesicouterine fistula; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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534 |
Lamontagne F., Agoritsas T., Siemieniuk R., Rochwerg B., Bartoszko J., Askie L., MacDonald H., Amin W., Bausch F.J., Burhan E., Cecconi M., Chanda D., Dat V.Q., Du B., Geduld H., Gee P., Nerina H., Hashimi M., Hunt B.J., Kabra S., Kanda S., Kawano-Dourado L., Kim Y.-J., Kissoon N., Kwizera A., Leo Y.-S., Mahaka I., Manai H., Mino G., Nsutebu E., Pshenichnaya N., Qadir N., Ranganathan S.S., Sabzwari S., Sarin R., Sharland M., Shen Y., Souza J.P., Stegemann M., Ugarte S., Venkatapuram S., Vuyiseka D., Preller J., Brignardello-Petersen R., Kum E., Qasim A., Zeraatkar D., Owen A., Guyatt G., Lytvyn L., Diaz J., Vandvik P.O., Jacobs M. |
15829826700;9734624300;23981410900;24345132600;56940778900;6603045596;57223601603;57221910483;57192706123;36058554600;16505953800;26029327700;56046962100;36131305900;36544760800;57204935223;57222260351;57222257762;55246203600;36488033400;57218352115;45561384900;7410198066;57221100878;35208486000;7004240142;56957092900;57211044922;57222258682;6603293930;6504380233;55622346400;6506124670;35240808700;23006204200;57203106412;16744841200;13205307600;23480876400;25654264800;25937500100;57079260800;55318241800;45161122100;57221470276;57206787520;57190033017;7202052634;8841196600;56600867200;13404130400;6602321455;36848322200; |
A living WHO guideline on drugs to prevent covid-19 |
2021 |
The BMJ |
372 |
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n526 |
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29 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102047389&doi=10.1136%2fbmj.n526&partnerID=40&md5=4b6b72a2cd8535abedd1f2abe649c5ac |
Université de Sherbrooke, Centre de Recherche Due Chu de Sherbrooke, Sherbrooke, QC, Canada; Division of General Internal Medicine, Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Magic Evidence Ecosystem Foundation, Oslo, Norway; Department of Medicine, McMaster University, Hamilton, ON, Canada; World Health Organization, Geneva, Switzerland; The Bmj, London, United Kingdom; Ministry of Health and Population, Cairo, Egypt; Geneva University Hospital, Switzerland; Infection Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Anesthesia and Intensive Care Medicine, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy; Adult Infectious Disease Centre, University Teaching Hospital, Lusaka, Zambia; Department of Infectious Diseases, Hanoi Medical University, Hanoi, Viet Nam; Peking Union Medical College Hospital, Beijing, China; Division of Emergency Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; United States; Royal Melbourne Hospital, Melbourne, Australia; Ziauddin University, Karachi, Pakistan; Guy's and St Thomas' Nhs Foundation Trust, London, United Kingdom; All India Institute of Medical Sciences, New Delhi, India; McMaster University (Alumnus), Canada; Pulmonary Division, Heart Institute (InCor)- Hcfmusp, Medical School, University of Sao Paulo, São Paulo, Brazil; Sungkyunkwan University, School of Medicine, Samsung Medical Center, Seoul, South Korea; Department of Paediatrics and Emergency Medicine, University of British Columbia, Vancouver, Canada; Department of Anaesthesia and Critical Care, College of Health Sciences, Makerere University, Kampala, Uganda; National Center for Infectious Diseases, Singapore, Singapore; Pangaea Harare, Zimbabwe; Emergency Medical Services, Faculty of Medicine, Tunis, Tunisia; Alcivar Hospital, Guayaquil, Ecuador; Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Central Research Institute of Epidemiology of Rospotrebnadzor, Moscow, Russian Federation; Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States; University of Colombo, Colombo, Sri Lanka; Aga Khan University, Karachi, Pakistan; National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India; St. George's University Hospital, London, United Kingdom; Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; University of Sao Paulo, Sao Paulo, Brazil; Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany; Faculty of Medicine, Andres Bello University, Indisa Clinic, Santiago, Chile; King's College, London, United Kingdom; University of Stellenbosch, South Africa; University of Liverpool, Liverpool, United Kingdom; Department of Health Economics and Health Management, Institute for Health and Society, University of Oslo, Oslo, Norway; Royal Free London Nhs Foundation Trust, London, United Kingdom; Research Institute, Hospital Do Coração (HCor), São Paulo, Brazil |
Lamontagne, F., Université de Sherbrooke, Centre de Recherche Due Chu de Sherbrooke, Sherbrooke, QC, Canada; Agoritsas, T., Division of General Internal Medicine, Division of Clinical Epidemiology, University Hospitals of Geneva, Geneva, Switzerland, Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Magic Evidence Ecosystem Foundation, Oslo, Norway; Siemieniuk, R., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Department of Medicine, McMaster University, Hamilton, ON, Canada; Rochwerg, B., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Department of Medicine, McMaster University, Hamilton, ON, Canada; Bartoszko, J., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Askie, L., World Health Organization, Geneva, Switzerland; MacDonald, H., The Bmj, London, United Kingdom; Amin, W., Ministry of Health and Population, Cairo, Egypt; Bausch, F.J., Geneva University Hospital, Switzerland; Burhan, E., Infection Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Cecconi, M., Department of Anesthesia and Intensive Care Medicine, Humanitas Clinical and Research Center-IRCCS, Rozzano, Italy; Chanda, D., Adult Infectious Disease Centre, University Teaching Hospital, Lusaka, Zambia; Dat, V.Q., Department of Infectious Diseases, Hanoi Medical University, Hanoi, Viet Nam; Du, B., Peking Union Medical College Hospital, Beijing, China; Geduld, H., Division of Emergency Medicine, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa; Gee, P., United States; Nerina, H., Royal Melbourne Hospital, Melbourne, Australia; Hashimi, M., Ziauddin University, Karachi, Pakistan; Hunt, B.J., Guy's and St Thomas' Nhs Foundation Trust, London, United Kingdom; Kabra, S., All India Institute of Medical Sciences, New Delhi, India; Kanda, S., McMaster University (Alumnus), Canada; Kawano-Dourado, L., Pulmonary Division, Heart Institute (InCor)- Hcfmusp, Medical School, University of Sao Paulo, São Paulo, Brazil, Research Institute, Hospital Do Coração (HCor), São Paulo, Brazil; Kim, Y.-J., Sungkyunkwan University, School of Medicine, Samsung Medical Center, Seoul, South Korea; Kissoon, N., Department of Paediatrics and Emergency Medicine, University of British Columbia, Vancouver, Canada; Kwizera, A., Department of Anaesthesia and Critical Care, College of Health Sciences, Makerere University, Kampala, Uganda; Leo, Y.-S., National Center for Infectious Diseases, Singapore, Singapore; Mahaka, I., Pangaea Harare, Zimbabwe; Manai, H., Emergency Medical Services, Faculty of Medicine, Tunis, Tunisia; Mino, G., Alcivar Hospital, Guayaquil, Ecuador; Nsutebu, E., Sheikh Shakhbout Medical City, Abu Dhabi, United Arab Emirates; Pshenichnaya, N., Central Research Institute of Epidemiology of Rospotrebnadzor, Moscow, Russian Federation; Qadir, N., Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, United States; Ranganathan, S.S., University of Colombo, Colombo, Sri Lanka; Sabzwari, S., Aga Khan University, Karachi, Pakistan; Sarin, R., National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India; Sharland, M., St. George's University Hospital, London, United Kingdom; Shen, Y., Shanghai Public Health Clinical Center, Fudan University, Shanghai, China; Souza, J.P., University of Sao Paulo, Sao Paulo, Brazil; Stegemann, M., Charité - Universitätsmedizin Berlin, Freie Universität Berlin, Humboldt-Universität zu Berlin, Department of Infectious Diseases and Respiratory Medicine, Berlin, Germany; Ugarte, S., Faculty of Medicine, Andres Bello University, Indisa Clinic, Santiago, Chile; Venkatapuram, S., King's College, London, United Kingdom; Vuyiseka, D., University of Stellenbosch, South Africa; Preller, J., World Health Organization, Geneva, Switzerland; Brignardello-Petersen, R., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Kum, E., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Qasim, A., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Zeraatkar, D., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Owen, A., University of Liverpool, Liverpool, United Kingdom; Guyatt, G., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Department of Medicine, McMaster University, Hamilton, ON, Canada; Lytvyn, L., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Diaz, J., World Health Organization, Geneva, Switzerland; Vandvik, P.O., Magic Evidence Ecosystem Foundation, Oslo, Norway, Department of Health Economics and Health Management, Institute for Health and Society, University of Oslo, Oslo, Norway; Jacobs, M., Royal Free London Nhs Foundation Trust, London, United Kingdom |
Clinical question What is the role of drugs in preventing covid-19? Why does this matter? There is widespread interest in whether drug interventions can be used for the prevention of covid-19, but there is uncertainty about which drugs, if any, are effective. The first version of this living guideline focuses on the evidence for hydroxychloroquine. Subsequent updates will cover other drugs being investigated for their role in the prevention of covid-19. Recommendation The guideline development panel made a strong recommendation against the use of hydroxychloroquine for individuals who do not have covid-19 (high certainty). How this guideline was created This living guideline is from the World Health Organization (WHO) and provides up to date covid-19 guidance to inform policy and practice worldwide. Magic Evidence Ecosystem Foundation (MAGIC) provided methodological support. A living systematic review with network analysis informed the recommendations. An international guideline development panel of content experts, clinicians, patients, an ethicist and methodologists produced recommendations following standards for trustworthy guideline development using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. Understanding the new recommendation The linked systematic review and network meta-analysis (6 trials and 6059 participants) found that hydroxychloroquine had a small or no effect on mortality and admission to hospital (high certainty evidence). There was a small or no effect on laboratory confirmed SARS-CoV-2 infection (moderate certainty evidence) but probably increased adverse events leading to discontinuation (moderate certainty evidence). The panel judged that almost all people would not consider this drug worthwhile. In addition, the panel decided that contextual factors such as resources, feasibility, acceptability, and equity for countries and healthcare systems were unlikely to alter the recommendation. The panel considers that this drug is no longer a research priority and that resources should rather be oriented to evaluate other more promising drugs to prevent covid-19. Updates This is a living guideline. New recommendations will be published in this article and signposted by update notices to this guideline. Readers note This is the first version of the living guideline for drugs to prevent covid-19. It complements the WHO living guideline on drugs to treat covid-19. When citing this article, please consider adding the update number and date of access for clarity. © Published by the BMJ Publishing Group Limited. |
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hydroxychloroquine; hydroxychloroquine; immunologic factor; coronavirus disease 2019; drug use; health care policy; high risk patient; human; immune response; infection prevention; nonhuman; practice guideline; Review; Severe acute respiratory syndrome coronavirus 2; World Health Organization; chemoprophylaxis; clinical decision making; drug effect; epidemiology; practice guideline; prevention and control; procedures; risk assessment; uncertainty; Chemoprevention; Clinical Decision-Making; COVID-19; Humans; Hydroxychloroquine; Immunologic Factors; Risk Assessment; SARS-CoV-2; Uncertainty; World Health Organization |
BMJ Publishing Group |
09598146 |
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33649077 |
Review |
Q1 |
1831 |
1579 |
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536 |
Tua Lubis A.M., Budimansyah M., Made Febry Siswanto I.G., Yanuarso Y., Marsetio A.F. |
15122639800;57222168054;57222170597;57222173063;57192180884; |
Functional outcome of implant-free bone-patellar tendon autograft versus hamstring autograft in arthroscopic anterior cruciate ligament reconstruction: A prospective study |
2021 |
Annals of Medicine and Surgery |
63 |
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102184 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101786286&doi=10.1016%2fj.amsu.2021.102184&partnerID=40&md5=2c7a67ad1a6831d518d84971baadc9be |
Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Jakarta, Pusat 10430, Indonesia; Persahabatan Hospital, Jl. Persahabatan Raya No.1, Jakarta, Timur 13230, Indonesia; Royal Progress Hospital, Jl. Danau Sunter Utara, Tanjung Priok, Jakarta, Utara 14350, Indonesia; Gatot Soebroto Army Hospital, Jl. Abdul Rahman Saleh Raya No.24, Senen, Jakarta, Pusat 10410, Indonesia |
Tua Lubis, A.M., Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Jakarta, Pusat 10430, Indonesia; Budimansyah, M., Persahabatan Hospital, Jl. Persahabatan Raya No.1, Jakarta, Timur 13230, Indonesia; Made Febry Siswanto, I.G., Royal Progress Hospital, Jl. Danau Sunter Utara, Tanjung Priok, Jakarta, Utara 14350, Indonesia; Yanuarso, Y., Gatot Soebroto Army Hospital, Jl. Abdul Rahman Saleh Raya No.24, Senen, Jakarta, Pusat 10410, Indonesia; Marsetio, A.F., Universitas Indonesia-Cipto Mangunkusumo General Hospital, Jl. Diponegoro No. 71, Jakarta, Pusat 10430, Indonesia |
Introduction: The use of implant in anterior cruciate ligament (ACL) reconstruction has been associated with several drawbacks including graft injury, implant osteolysis, implant migration and soft tissue irritation. Implant-free ACL reconstruction surgery offers additional benefits of cost-effective, improved graft incorporation and ease of revision surgery. Our study aimed to compare the functional outcome of ACL reconstruction by using bone-patellar tendon autograft with press-fit fixation technique and hamstring autografts with implant. Methods: A prospective cohort study design was used. Between March 2013 and March 2014, 12 patients underwent patella tendon-bone graft fixated by press-fit fixation technique (implant-free), while 24 patients underwent ACL reconstruction using implant-fixated hamstring tendon graft. Objective functional outcome was measured by using rolimeter, and subjective functional outcome was measured according to the functional score of IKDC, Tegner-Lysholm and KOOS. Results: Both techniques have shown no significant difference in terms of functional outcome, whether assessed by rolimeter measurement, IKDC score, Tegner-Lysholm, KOOS score between implant group and implant-free group, preoperatively and postoperatively. Discussion: Our study results are in line with several other studies with various follow-up time and systematic review. With the right technique, graft harvesting of patella tendon-tibial tuberosity bone block can be successfully performed, and associated donor site morbidity can be avoided. Conclusion: Patients who underwent ACL reconstruction using implant-free technique by press-fit fixation had comparable outcome with ACL reconstruction with implant, objectively and subjectively. This technique should be further revisited and reevaluated. © 2021 The Authors |
Anterior cruciate ligament; Anterior cruciate ligament injury; Bone-patellar tendon; Implant-free ACL reconstruction; Press-fit fixation |
adult; anterior cruciate ligament reconstruction; arthroscopic surgery; Article; bone patellar tendon bone graft; cohort analysis; controlled study; female; follow up; graft harvesting; hamstring tendon; human; Knee Injury and Osteoarthritis Outcome Score; male; nuclear magnetic resonance imaging; press fit graft fixation technique; prospective study; randomized controlled trial; scoring system; soccer; Tegner activity score; Tegner-Lysholm Knee Scoring Scale; tibial tuberosity; traffic accident; volleyball |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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538 |
Seswandhana R., Makrufardi F., Sudjatmiko G. |
8718699600;57214993245;16025731000; |
Fistula incidence after primary repair and correlation with cleft width-to-palatum width ratio: A prospective cohort study |
2021 |
Annals of Medicine and Surgery |
63 |
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102183 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101659670&doi=10.1016%2fj.amsu.2021.102183&partnerID=40&md5=ad5a9021a2b2389751b7ee5f65e256ee |
Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Department of Plastic Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Seswandhana, R., Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Makrufardi, F., Plastic, Reconstructive, and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito Hospital, Yogyakarta, 55281, Indonesia; Sudjatmiko, G., Department of Plastic Reconstructive, and Aesthetic Surgery, Faculty of Medicine, Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Cleft lip with or without cleft palate is one of the most common birth defects and is certainly the most visible. Fistula rate after primary palatoplasty was ranging between 10 and 23% and could be detected in the first three weeks after surgery. The cleft width is the frequent factor which was assumed to correspond to fistula occurrence. This study aimed to find correlation between fistula occurrence with cleft width and palatum width ratio after primary palate repair. Methods: A prospective cohort study was conducted on 16 subjects, which consisted of 10 males and 6 females. We measured width of cleft palate, width of rest palate and width of palate arch on three level measurements (posterior, junction and anterior). The surgery was performed using the two-flap and three layers suturing technique. Results: Sixteen patients were enrolled in this study during January and February 2008. Ten patients were diagnosed with unilateral cleft palate while six patients had bilateral cleft palate. Mean of age was 22.31 ± 5.86 month. Correlation analysis between fistula occurrence and cleft width, cleft width-remnant palate width ratio and cleft width-palate arch width ratio using logistic regression did not show statistical correlation, and the same result was found between fistula occurrence and hemoglobin level, white blood count, nutritional status, cleft type and caries dentis factors (p > 0.05). Conclusion: Width of the cleft is not a factor associated with fistula occurrence. Two-flap three layers technique could be considered as a simple technique and gives a low rate of fistula occurrence. © 2021 |
Cleft width and palate width ratio; Fistula occurrence; Primary palatoplasty; Two-flap three layers suturing technique |
amoxicillin; epinephrine; hemoglobin; lidocaine; paracetamol; anemia; anthropometry; Article; blood cell count; child; cleft palate; clinical article; cohort analysis; controlled study; correlation analysis; dental caries; female; fistula; gestational age; hemoglobin blood level; human; leukocyte count; major clinical study; male; nutritional status; obesity; palatoplasty; primary palate; prospective study; protein expression; suture technique |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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539 |
Alfarissi F., Putri N.M., Atmoko W. |
57197871808;57192904294;57193125664; |
Multidisciplinary approach for large retroperitoneal abscess management: A case report |
2021 |
International Journal of Surgery Case Reports |
80 |
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105668 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101608960&doi=10.1016%2fj.ijscr.2021.105668&partnerID=40&md5=9f69d079d51ac679c79a59e093f702ce |
Department of Urology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Indonesia; Plastic Reconstructive and Esthetic Division, Department of Surgery, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Indonesia |
Alfarissi, F., Department of Urology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Indonesia; Putri, N.M., Plastic Reconstructive and Esthetic Division, Department of Surgery, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Indonesia; Atmoko, W., Department of Urology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Indonesia |
Introduction and importance: Retroperitoneal abscess is a rare disease that is often difficult to diagnose and require multidisciplinary management. We report a case of large retroperitoneal abscess and the usage lumbar artery perforator (LAP) for the defect closure. Case presentation: A 52-year-old-women was admitted to our emergency with a chief complaint of left flank pain. Patient had history of multiple genitourinary tract procedure and diabetes mellitus type 2. We found a bulging mass on the left flank accompanied by pressure pain. A contrast CT scan revealed a large abscess on the retroperitoneal region that involved the left retroperitoneal hemiabdomen muscles. We performed multistage-treatment comprising of radical abscess debridement, followed by honey-impregnated gauze and negative pressure wound therapy for wound bed preparation. Post-debridement, the defect was closed with LAP and keystone flap. LAP flap was raised and transposed to close the defect on the caudal area. One-month follow up showed the outcome was satisfactory. Clinical discussion: In our case, the source of infection was thought to origin from genitourinary infection. The history of multiple urology procedures and diabetes mellitus became the main risk factors. Multistage managements were needed to eradicate the abscess. The usage of NPWT and honey-impregnated gauze was proven successful in preparing the wound bed prior to definitive closure. Lastly, the utilization LAP flap combined with keystone flap showed satisfactory outcome for defect closure. Conclusion: The management of patient with large retroperitoneal abscess require multidisciplinary approach including extensive debridement and well-prepared wound bed. In this report, LAP flap was proven reliable option to resurface large defect around flank area. © 2021 The Authors |
Honey-impregnated gauze; Keystone flap; Lumbar artery perforator flap; Multidisciplinary approach; NPWT; Retroperitoneal abscess |
antidiabetic agent; glucose; abdominal wall musculature; abscess drainage; adult; Article; blister; case report; clinical article; clinical outcome; diabetic ketoacidosis; disease severity; emergency ward; erythema; extracorporeal shock wave lithotripsy; female; flank mass; flank pain; follow up; glucose blood level; health care system; human; keystone flap; kidney calyx; leukocytosis; lumbar artery; middle aged; multidisciplinary approach; nephrolithiasis; non insulin dependent diabetes mellitus; patient satisfaction; perforator flap; plastic surgery; postoperative period; priority journal; pus; pyelolithotomy; pyelonephritis; retroperitoneal abscess; risk factor; skin necrosis; staghorn stone; subcutaneous tissue; surgical debridement; surgical wound; tissue flap; vacuum assisted closure |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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542 |
Kamal A.F., Anshori F., Kodrat E. |
56648996700;57219779719;57191430080; |
Osteofibrous dysplasia-like adamantinoma versus osteofibrous dysplasia in children: A case report of challenging diagnosis |
2021 |
International Journal of Surgery Case Reports |
80 |
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105599 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101451168&doi=10.1016%2fj.ijscr.2021.01.093&partnerID=40&md5=97e46a083ddb3d0f1c9018ef6250c9ed |
Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Musculoskletal Pathology Division, Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Anshori, F., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Kodrat, E., Musculoskletal Pathology Division, Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Osteofibrous dysplasia (OFD) and Osteofibrous dysplasia-like Adamantinoma have a similar appearance both in clinical and radiography, but different in its histopathology. Despite this similarity, the treatment and prognosis are different, therefore the diagnosis should be established precisely. Case illustration: A three-year-old boy was admitted to hospital after falling on his lower leg. A bead size lump appeared on his tibia with pain and swelling, which later became enlarged. Diagnosis of osteofibrous dysplasia and adamantinoma was considered. We performed limb-salvage procedure by curretage, bone grafting, and internal fixation application. The histology section showed woven bone rimmed by polygonal osteoblast cell with intervening fibrous stroma and small nests of tumour cells raised the possibility of epithelial differentiation. The positivity for cytokeratin immunostaining confirmed the diagnosis as osteofibrous dysplasia-like adamantinoma. In this case it is a very rare spectrum of malignancy in children. Discussion: These two tumor entities have identical radiographic characteristics, histopathology features the distinction between classic adamantinoma and OFD-like adamantinoma based on the predominant epithelial component. The relationship of osteofibrous dysplasia with adamantinoma is unclear. Several authors considered possible calling relationship osteofibrous dysplasia as “juvenile adamantinoma”. However, does not rule out the possible existence of de novo osteofibrous dysplasia not related to adamantinoma. Conclusions: OFD-like adamantinoma and Osteofibrous Dysplasia had similar histopathology pattern, a pathologist must be aware of this feature and perform immunohistochemical staining for keratin particularly when the histopathological feature of osteofibrous dysplasia showed small nests of tumor cells within the fibrous stroma. diagnostic challenging and require multidisciplinary approach. © 2021 The Authors |
Immunohistochemical staining; Osteofibrous dysplasia; Osteofibrous dysplasia-like adamantinoma |
cytokeratin; ameloblastoma; Article; bone transplantation; cancer diagnosis; carcinogenesis; case report; cell differentiation; child; childhood cancer; clinical article; comparative study; curettage; dysplasia; epithelium cell; falling; fibroblast; histopathology; human; immunohistochemistry; intraoperative period; leg pain; leg swelling; limb salvage; male; nuclear magnetic resonance imaging; osteofibrous dysplasia; osteofibrous dysplasia like adamantinoma; preschool child; priority journal; proximal tibia |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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543 |
Harun J., Akbar D.L. |
57222088137;57219271823; |
The management of neglected spondylitis tuberculosis with dislocated C1 and C2 odontoid destruction: A case report |
2021 |
International Journal of Surgery Case Reports |
80 |
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105606 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101419349&doi=10.1016%2fj.ijscr.2021.01.100&partnerID=40&md5=72a992cd28af156e0515ea5e37de0ef9 |
Department of Orthopaedic and Traumatology, Indonesia Army Central Hospital, Indonesia; Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Indonesia |
Harun, J., Department of Orthopaedic and Traumatology, Indonesia Army Central Hospital, Indonesia; Akbar, D.L., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Central General Hospital, Indonesia |
Introduction and importance: Spinal tuberculosis was the most common TB infection in human body. Musculoskeletal tuberculosis (TB) mostly affected lower thoracal or upper lumbar spine. However, TB infection can also occurs along vertebral spine. We reported a rare case about TB infection in cervical spine. We provided the clinical manifestation and therapeutic method for the patient. Cervical TB infection is a very rare case. Especially, when it involves in C1 and C2 like we provided on this case. Case presentation: A 24 years-old male came to the orthopaedic clinic with neck pain that aggravated by neck movement. He previously diagnosed with TB infection on his lung within 3 months. We performed x-ray data to determine the source of neck pain. Examination revealed anterior collapse of C1, destruction of odontoid process, and soft tissue swelling. We also performed MRI cervical to assess the destruction of anterior corpus C1. Clinical discussion: We decided to operate the patient with reposition and posterior stabilization of C1 using occipital plate from posterior approach and added some synthetic bone graft. The medical treatment is anti-tuberculosis drugs, usually conducted conservatively in mild-to-moderate cases. But, if there is deterioration in neurological deficit or persisting deficit with spinal cord compression, such as C1 and C2 involvement, surgery can be considered. There are two types of surgery; posterior fixation and fusion and anterior release and posterior stabilization. Conclusion: TB musculoskeletal infection must be evaluated regularly to consider the perfect time for additional surgical treatment. The good decision to operate the moderate to severe case could improve the patient's functional outcome. © 2021 |
Cervical spine; Neck pain; Posterior stabilization; Spinal tuberculosis; Spondylitis TB |
povidone iodine; streptomycin; tuberculostatic agent; adult; antibiotic therapy; Article; case report; clinical article; human; laminectomy; male; neck pain; neglected disease; nuclear magnetic resonance imaging; odontoid process; priority journal; spinal cord decompression; spine stabilization; tuberculous spondylitis; X ray; young adult |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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