No records
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578 |
Arguni E., Karyanti M.R., Satari H.I., Hadinegoro S.R. |
8520598700;56290680800;57226214366;56893685800; |
Diphtheria outbreak in Jakarta and Tangerang, Indonesia: Epidemiological and clinical predictor factors for death |
2021 |
PLoS ONE |
16 |
2 February |
e0246301 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100508974&doi=10.1371%2fjournal.pone.0246301&partnerID=40&md5=d5c31533e8d632bb7459927c7da0cce2 |
Department of Child Health, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Arguni, E., Department of Child Health, Faculty of Medicine Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Karyanti, M.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Satari, H.I., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hadinegoro, S.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background In 2017, a diphtheria outbreak occurred in several provinces in Indonesia. The aim of this study was to identify predictors of mortality outcome of pediatric patients with clinical diphtheria. Methods A retrospective cohort study was conducted using patient medical records at five referral hospitals in the Province of Jakarta and one in Tangerang District, Banten Province during January 2017 to 31 August 2018. All children in the age group of 1-18 years old discharged with diagnosis of clinical diphtheria formed the study group. All anonymized patient data were evaluated for demographic issues, clinical features, immunization status, complication, laboratory profiles and outcome. Results A total of 283 patients with clinical diphtheria were included in the study group with case fatality rate of 3.5%. All mortal patients had the complication of myocarditis. Regression analyses revealed factors for predicting mortality. Incomplete primary diphtheria toxoid immunization, stridor, bull neck, leukocytosis ≥15 ×109 cells/L and thrombocytopenia ≤150 x109 cells/L in each combination for 2 predictors modeling were correlated with death. Conclusions We report key predictors of mortality in pediatric patients with clinical diphtheria. The presence of these features when admitted to the hospital must be taken into account, because they can lead to fatal outcome. © 2021 Arguni et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
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adolescent; child; cohort analysis; complication; diphtheria; epidemic; female; hospitalization; human; immunization; Indonesia; infant; male; medical record; mortality; myocarditis; preschool child; regression analysis; retrospective study; vaccination; Adolescent; Child; Child, Preschool; Cohort Studies; Diphtheria; Disease Outbreaks; Female; Hospitalization; Humans; Immunization; Indonesia; Infant; Male; Medical Records; Myocarditis; Regression Analysis; Retrospective Studies; Vaccination |
Public Library of Science |
19326203 |
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33539453 |
Article |
Q1 |
990 |
4434 |
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581 |
Nugroho S.W., Perkasa S.A.H., Gunawan K., Manuhutu Y.N., Rahman M.A., Rizky A. |
57460519700;57204105609;57195935319;57221807460;57221807438;57221806899; |
Predicting outcome of hemifacial spasm after microvascular decompression with intraoperative monitoring: A systematic review |
2021 |
Heliyon |
7 |
2 |
e06115 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100277933&doi=10.1016%2fj.heliyon.2021.e06115&partnerID=40&md5=b7d2f2e7bfd453c5d93d9b6eb24a6a19 |
Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia |
Nugroho, S.W., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Perkasa, S.A.H., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Gunawan, K., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Manuhutu, Y.N., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Rahman, M.A., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia; Rizky, A., Neurofunctional Division, Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Indonesia |
Hemifacial spasm, Microvascular decompression, Intraoperative monitoring, Lateral spread response, Abnormal muscle response. © 2021 The AuthorsBackground: Microvascular decompression has been established as a primary treatment for hemifacial spasm. Intraoperative monitoring is used during the surgery to guide neurosurgeons to determine whether the decompression of facial nerve from the vessel is sufficient. We performed a systematic review to assess the role of lateral spread response (LSR) monitoring in predicting hemifacial spasm outcomes after microvascular decompression. Method: A systematic search of PubMed, ScienceDirect, Cochrane, and Google Scholar was conducted. We included studies that performed microvascular decompression surgery with intraoperative monitoring analyzing the correlation between lateral spread response and spasm relief. A critical appraisal was conducted for selected studies. Result: Twenty-two studies comprising 6404 cases of hemifacial spasm, which underwent microvascular decompression surgery with intraoperative monitoring, were included. Of 15 articles that assessed symptoms shortly after surgery, 12 studies showed a significant correlation between lateral spread response resolution and disappearance of spasm. Four of six studies that evaluated the outcome at 3-month follow-up showed significant relationship between LSR and outcome, so did five of six articles that assessed spasm relief at 6-month follow-up. As much as 62.5% of studies (10 of 16) showed the result at long-term follow-up (≥1-year) was not significant. Conclusion: Intraoperative monitoring during microvascular decompression surgery can be a useful tool to predict hemifacial spasm resolution. Though long-term outcomes of patients with LSR relief and persistence are similar, resolution of symptoms shortly after surgery will provide comfort to patients thereby improving their quality of life. © 2021 The Authors |
Abnormal muscle response; Hemifacial spasm; Intraoperative monitoring; Lateral spread response; Microvascular decompression |
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Elsevier Ltd |
24058440 |
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Review |
Q1 |
455 |
10919 |
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595 |
Adiwinata Pawitan J. |
6508348067; |
Convalescent plasma for COVID-19 considerations |
2021 |
Transfusion and Apheresis Science |
60 |
1 |
102927 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85090304480&doi=10.1016%2fj.transci.2020.102927&partnerID=40&md5=2c7b5b13bfb02cae0ec9ff791413074f |
Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia; Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
Adiwinata Pawitan, J., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine, Universitas Indonesia, Indonesia, Stem Cell and Tissue Engineering Research Center, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia |
[No abstract available] |
Convalescent plasma; COVID-19 |
immunoglobulin A; neutralizing antibody; oxyhemoglobin; SARS-CoV-2 convalescent plasma; adverse event; anaphylaxis; antibody titer; case study; China; coronavirus disease 2019; critically ill patient; cytokine storm; human; Letter; pilot study; transfusion related acute lung injury; treatment contraindication; virus virulence; Coronavirus infection; passive immunization; plasma; therapy; Coronavirus Infections; COVID-19; Humans; Immunization, Passive; Plasma; SARS-CoV-2 |
Elsevier Ltd |
14730502 |
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32878733 |
Letter |
Q3 |
450 |
11031 |
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601 |
Siswanto J.E., Bos A.F., Dijk P.H., Rohsiswatmo R., Irawan G., Sulistijono E., Sianturi P., Wisnumurti D.A., Wilar R., Sauer P.J.J. |
57205060577;36839156800;6701798049;55533574600;57221815645;57218101844;57192896614;57200574807;57201130415;57221818237; |
Multicentre survey of retinopathy of prematurity in Indonesia |
2021 |
BMJ Paediatrics Open |
5 |
1 |
e000761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100318807&doi=10.1136%2fbmjpo-2020-000761&partnerID=40&md5=0c40a01ee7a27d4289754e988161b732 |
Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia |
Siswanto, J.E., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands, Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Bos, A.F., Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Dijk, P.H., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Rohsiswatmo, R., Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Irawan, G., Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Sulistijono, E., Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Sianturi, P., Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Wisnumurti, D.A., Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Wilar, R., Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia; Sauer, P.J.J., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands |
Background: The incidence of retinopathy of prematurity (ROP) is higher in Indonesia than in high-income countries. In order to reduce the incidence of the disease, a protocol on preventing, screening and treating ROP was published in Indonesia in 2010. To assist the practical implementation of the protocol, meetings were held in all Indonesia regions, calling attention to the high incidence of ROP and the methods to reduce it. In addition, national health insurance was introduced in 2014, making ROP screening and treatment accessible to more infants. Objective To evaluate whether the introduction of both the guideline drawing attention to the high incidence of ROP and national health insurance may have influenced the incidence of the disease in Indonesia. Setting Data were collected from 34 hospitals with different levels of care: national referral centres, university-based hospitals, and public and private hospitals. Methods: A survey was administered with questions on admission numbers, mortality rates, ROP incidence, and its stages for 2016-2017 in relation to gestational age and birth weight. Results: We identified 12 115 eligible infants with a gestational age of less than 34 weeks. Mortality was 24% and any stage ROP 6.7%. The mortality in infants aged less than 28 weeks was 67%, the incidence of all-stage ROP 18% and severe ROP 4%. In the group aged 28-32 weeks, the mortality was 24%, all-stage ROP 7% and severe ROP 4%-5%. Both mortality and the incidence of ROP were highest in university-based hospitals. Conclusions: In the 2016-2017 period, the infant mortality rate before 32 weeks of age was higher in Indonesia than in high-income countries, but the incidence of ROP was comparable. This incidence is likely an underestimation due to the high mortality rate. The ROP incidence in 2016-2017 is lower than in surveys conducted before 2015. This decline is likely due to a higher practitioner awareness about ROP and national health insurance implementation in Indonesia. © Author(s) (or their employer(s)) 2021. |
epidemiology; health services research; mortality; neonatology; ophthalmology |
birth weight; controlled study; data collection method; disease severity; female; gestational age; health services research; health survey; high income country; human; incidence; Indonesia; infant; infant mortality; major clinical study; male; mortality rate; multicenter study; national health insurance; patient referral; physician; practice guideline; prematurity; priority journal; private hospital; public hospital; retrolental fibroplasia; Review; teaching hospital; university hospital |
BMJ Publishing Group |
23999772 |
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Review |
Q1 |
821 |
5832 |
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602 |
Yusuf P.A., Hubka P., Tillein J., Vinck M., Kral A. |
57192156597;6506008977;6602884109;35338597200;55668482500; |
Deafness Weakens Interareal Couplings in the Auditory Cortex |
2021 |
Frontiers in Neuroscience |
14 |
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625721 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100543064&doi=10.3389%2ffnins.2020.625721&partnerID=40&md5=a896b3ce6070ccfa904918c9e995ca32 |
Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany; Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Department of Otorhinolaryngology, Goethe University, Frankfurt am Main, Germany; MedEL Company, Innsbruck, Austria; Ernst Strüngmann Institut for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany; Donders Centre for Neuroscience, Radboud University, Department of Neuroinformatics, Nijmegen, Netherlands; Department of Biomedical Sciences, School of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia |
Yusuf, P.A., Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Hubka, P., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Tillein, J., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany, Department of Otorhinolaryngology, Goethe University, Frankfurt am Main, Germany, MedEL Company, Innsbruck, Austria; Vinck, M., Ernst Strüngmann Institut for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany, Donders Centre for Neuroscience, Radboud University, Department of Neuroinformatics, Nijmegen, Netherlands; Kral, A., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany, Department of Biomedical Sciences, School of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia |
The function of the cerebral cortex essentially depends on the ability to form functional assemblies across different cortical areas serving different functions. Here we investigated how developmental hearing experience affects functional and effective interareal connectivity in the auditory cortex in an animal model with years-long and complete auditory deprivation (deafness) from birth, the congenitally deaf cat (CDC). Using intracortical multielectrode arrays, neuronal activity of adult hearing controls and CDCs was registered in the primary auditory cortex and the secondary posterior auditory field (PAF). Ongoing activity as well as responses to acoustic stimulation (in adult hearing controls) and electric stimulation applied via cochlear implants (in adult hearing controls and CDCs) were analyzed. As functional connectivity measures pairwise phase consistency and Granger causality were used. While the number of coupled sites was nearly identical between controls and CDCs, a reduced coupling strength between the primary and the higher order field was found in CDCs under auditory stimulation. Such stimulus-related decoupling was particularly pronounced in the alpha band and in top–down direction. Ongoing connectivity did not show such a decoupling. These findings suggest that developmental experience is essential for functional interareal interactions during sensory processing. The outcomes demonstrate that corticocortical couplings, particularly top-down connectivity, are compromised following congenital sensory deprivation. © Copyright © 2021 Yusuf, Hubka, Tillein, Vinck and Kral. |
bottom-up; cochlear implant; congenital deafness; predictive coding; synchronization; top–down |
adult; alpha rhythm; animal experiment; animal model; animal tissue; Article; auditory cortex; auditory stimulation; beta rhythm; cochlea; controlled study; functional connectivity; hearing acuity; hearing impairment; local field potential; nonhuman |
Frontiers Media S.A. |
16624548 |
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Article |
Q2 |
1499 |
2279 |
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604 |
Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D., Wuyung P.E. |
56692904000;32067462200;41461551400;36673726800;57192889605; |
Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA |
2021 |
Frontiers in Pharmacology |
11 |
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603235 |
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10 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100565118&doi=10.3389%2ffphar.2020.603235&partnerID=40&md5=5b5af16fb791027b3a94b95b0b6da88b |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facility, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Wuyung, P.E., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facility, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Cisplatin has been used for decades for the treatment of ovarian cancer. However, despite its potent anticancer effect, cisplatin’s efficacy as a single agent was inadequate in patients with advanced stage. Curcumin has been shown to sensitize cisplatin activity in several cancer models. However, the low bioavailability of curcumin has limited its anticancer potential. Hence, nano-formulation of curcumin was developed to increase its therapeutic efficacy in ovarian cancer. The objective of this study was to investigate the mechanism of curcumin nanoparticles given in combination with cisplatin in rat ovarian carcinoma induced by dimethylbenz(a)anthracene (DMBA). The administration of cisplatin and nanocurcumin resulted in a significant reduction in ovarian tumor volume and weight. Furthermore, there were reduction in expressions of Ki67, TGF-β, PI3K, and Akt phosphorylation. Co-treatment of cisplatin and nanocurcumin also reduced JAK expression, STAT3 phosphorylation, and reduced IL-6 concentrations. Altogether, nanocurcumin, given as a co-treatment with cisplatin has therapeutic potential in ovarian cancer models by inhibiting proliferation through downregulation of PI3K/Akt and JAK/STAT3 signaling pathways. © Copyright © 2021 Sandhiutami, Arozal, Louisa, Rahmat and Wuyung. |
cisplatin; curcumin; interleukin-6; nanoparticles; ovarian carcinoma; TGF-β |
cisplatin; curcumin; dimethylbenz[a]anthracene; interleukin 6; Janus kinase; Ki 67 antigen; nanoparticle; phosphatidylinositol 3 kinase; protein kinase B; STAT3 protein; transforming growth factor beta; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; biological model; cell proliferation; controlled study; down regulation; drug efficacy; enzyme inhibition; female; JAK-STAT signaling; nonhuman; ovary carcinoma; Pi3K/Akt signaling; protein expression; protein phosphorylation; rat; tumor volume; tumor weight |
Frontiers Media S.A. |
16639812 |
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Article |
Q1 |
1384 |
2619 |
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605 |
Unggul D.B., Abdullah S., Rachman A. |
57221961543;57204563168;57217184320; |
Laterality condition analysis on non-arteritic anterior ischemic optic neuropathy patient in one of the hospital in Jakarta with medical data mining |
2021 |
Journal of Physics: Conference Series |
1725 |
1 |
012096 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100803241&doi=10.1088%2f1742-6596%2f1725%2f1%2f012096&partnerID=40&md5=38c1992b179967890ac62988e4c116ad |
Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Unggul, D.B., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Abdullah, S., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) is a disease caused by blood shortages in the artery that supplies the optic disc. Risk factors for NAION are hypertension, obesity, diabetes, dislipidemia, smoking, hypercoagulable state, cardiovascular disease, and stroke. NAION can result from unilateral or bilateral conditions. This study will focus on the identification of important factors that could distinguish characteristics between unilateral and bilateral patients. Random forest method is applied to obtain factors that can consistently distinguish characteristic between each laterality condition. Decision trees and the logistic regression method are added to obtain the visualization of the role of each important factors in the form of classification tree and the risk comparison of patients for experiencing a certain laterality condition by using odds ratios. The important factors based on random forest model are onset, fasting blood glucose levels, high density lipoprotein levels, age, two-hour postprandial glucose levels, and low density lipoprotein levels. Based on the odds ratio, advancing age and high density lipoprotein levels will decrease the risk of patients experiencing bilateral condition; on the other hand, the risk of bilateral condition will increase if other important factors are also increased. © 2021 Journal of Physics: Conference Series. |
Decision tree; Laterality; Logistic regression; Random forest |
Blood; Decision trees; Glucose; Lipoproteins; Logistic regression; Medical computing; Random forests; Blood glucose level; Cardio-vascular disease; Classification trees; High density lipoprotein levels; Logistic regression method; Low density lipoproteins; Random forest methods; Random forest modeling; Data mining |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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606 |
Hanifah N., Wiweko B., Bowolaksono A. |
57200075370;43061741400;57205093224; |
FSHR and LHR mRNA expression in granulosa cells of poor responder |
2021 |
Journal of Physics: Conference Series |
1725 |
1 |
012057 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100793552&doi=10.1088%2f1742-6596%2f1725%2f1%2f012057&partnerID=40&md5=498a20aef40d78ffcc6b9fa74da8dec6 |
Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Hanifah, N., Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Wiweko, B., Department of Obstetric and Gynecology, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Bowolaksono, A., Department of Biology, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia |
In Vitro Fertilization (IVF) is one of the most commonly used procedures to help pregnancies in couples who have infertility problems. One of the problems of infertility is poor ovarian response and the woman who experiences it is known as poor responder. Poor responders do not have an adequate ovarian response to gonadotropin in ovarian stimulation. The success of fertilization in poor responders tends to be low due to low quantity and is generally followed by low oocyte quality. Gonadotropins consisting of FSH and LH, play a role in follicle development and ovulation. The follicle response in capturing gonadotropins depends on the exact bond between the hormone and its receptor (FSHR and LHR) in the granulosa cells surrounding the oocyte. The purpose of this research is to know the expression level of fshr and lhr mRNA in granulosa cells of poor responders through real-time PCR method which then tested statistically using t-test. Fourteen samples of each poor responders and normal women were used in this research. The results showed insignificant differences between expression level of fshr and lhr mRNA in granulosa cells of poor responders and normal women (p > 0.05). © 2021 Journal of Physics: Conference Series. |
FSHR; LHR; Poor ovarian response; Real-time PCR |
Cytology; Polymerase chain reaction; Expression levels; Follicle development; Granulosa cells; In-vitro; mRNA expression; Real-time PCR method; T-tests; Cells |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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607 |
Lestari D.A., Abdullah S., Rachman A. |
56119337300;57204563168;57217184320; |
Identification of factors associated with hypothyroidism due to radiotherapy in patients with nasopharyngeal cancer (Case study of nasopharyngeal cancer in one of the hospitals in Jakarta) |
2021 |
Journal of Physics: Conference Series |
1725 |
1 |
012027 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100793360&doi=10.1088%2f1742-6596%2f1725%2f1%2f012027&partnerID=40&md5=eb87ed0fd4bc75637854a08478652d08 |
Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Lestari, D.A., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Abdullah, S., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Nasopharyngeal cancer is an abnormal cell growth that develops around the nasopharynx. Treatment of nasopharyngeal cancer patients includes chemotherapy or radiotherapy. Both treatments have side effects in patients. In this study, we will focus on hypothyroidism as a side effect of radiotherapy in the treatment of patients with nasopharyngeal cancer. Hypothyroidism is a condition when the thyroid gland is unable to produce enough thyroid hormone. The main goal of this study is to identify the factors associated with hypothyroidism. To achieve this goal, classification tree and logistic regression methods will be used. Classification tree is used to obtain important variables in the classification of subject classes. Then, logistic regression is used to quantify the risk of variables that appear in the classification tree, hypothyroidism risk factors, and hypothyroidism marker factors. Based on the analysis, it was found that the factors associated in this study were variable symptom, physical sign, smoking habits, gender, age, BMI (Body Mass Index), TSH (Thyroid Stimulating Hormone) and fT4 (free thyroxine) hormones, and also all items on Zulewski score, except items delayed ankle reflex and slow movements. These factors associated tended to increase the risk of hypothyroidism, except for the fT4 hormone and BMI. © 2021 Journal of Physics: Conference Series. |
Classification tree; Hypothyroidism; Logistic regression; Marker factors; Risk factors |
Cell proliferation; Chemotherapy; Hormones; Logistic regression; Radiotherapy; Body mass index; Classification trees; Logistic regression method; Nasopharyngeal cancer; Risk factors; Thyroid glands; Thyroid hormones; Thyroid stimulating hormones; Diseases |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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608 |
Lukman P.A., Abdullah S., Rachman A. |
57221968648;57204563168;57217184320; |
Bayesian logistic regression and its application for hypothyroid prediction in post-radiation nasopharyngeal cancer patients |
2021 |
Journal of Physics: Conference Series |
1725 |
1 |
012010 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100754485&doi=10.1088%2f1742-6596%2f1725%2f1%2f012010&partnerID=40&md5=902f22d97f61ad13843e9bbe6a66f42e |
Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Lukman, P.A., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Abdullah, S., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Rachman, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Logistic regression models are commonly used to model response variables in the form of categorical variables with several predictor variables. The contribution of the predictor variable to the response variable is expressed through a regression coefficient (β). Therefore, it is necessary to estimate β. This study discusses the estimation of β using the Bayesian method. Bayesian approach utilizes a combination of information from sample data and prior information about the characteristics of the parameters of interest, resulting in the updated information, namely the posterior. Bayesian method thus can overcome the problem if the quality of the sample data does not support observation. Bayesian logistic regression method will be used in analyzing post-radiation nasopharyngeal cancer (NPC) patient data, using measurement on Zulewski's score components. Markov Chain Monte Carlo with Gibbs Sampling were used to obtain the sample from posterior distribution. Convergent estimates were obtained, and the result showed that Zulewski's component scores only were not enough to explain the hypothyroidism in NPC. Additional information is required in order to explain the incidence of hypothyroidism in NPC. © 2021 Journal of Physics: Conference Series. |
Bayesian logistic regression; Gibbs sampling; Logistic regression; Markov chain monte carlo; Nasopharyngeal cancer |
Bayesian networks; Diseases; Hospital data processing; Markov chains; Radiotherapy; Categorical variables; Logistic regression method; Logistic regression models; Markov Chain Monte-Carlo; Nasopharyngeal cancer; Posterior distributions; Regression coefficient; Updated informations; Logistic regression |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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