No records
|
669 |
Syafira N., Graudins A., Yarema M., Wong A. |
57222178056;55790181600;8550407600;52265101200; |
Comparing development of liver injury using the two versus three bag acetylcysteine regimen despite early treatment in paracetamol overdose |
2021 |
Clinical Toxicology |
|
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119253032&doi=10.1080%2f15563650.2021.1998518&partnerID=40&md5=71ecde369075113c2b3f41b9bb20e452 |
Department of Medicine, School of Clinical Science at Monash Health, Monash UniversityVIC, Australia; Faculty of Medicine, Universitas Indonesia, Special Capital Region of Jakarta, Indonesia; Monash Toxicology Unit, Dandenong Hospital, Monash HealthVIC, Australia; Poison and Drug Information Service, Alberta Health Services, Calgary, Canada; Department of Emergency Medicine, University of Calgary, Calgary, Canada; Austin Toxicology Unit, Austin HealthVIC, Australia; Department of Critical Care, University of MelbourneVIC, Australia |
Syafira, N., Department of Medicine, School of Clinical Science at Monash Health, Monash UniversityVIC, Australia, Faculty of Medicine, Universitas Indonesia, Special Capital Region of Jakarta, Indonesia; Graudins, A., Department of Medicine, School of Clinical Science at Monash Health, Monash UniversityVIC, Australia, Monash Toxicology Unit, Dandenong Hospital, Monash HealthVIC, Australia; Yarema, M., Poison and Drug Information Service, Alberta Health Services, Calgary, Canada, Department of Emergency Medicine, University of Calgary, Calgary, Canada; Wong, A., Department of Medicine, School of Clinical Science at Monash Health, Monash UniversityVIC, Australia, Austin Toxicology Unit, Austin HealthVIC, Australia, Department of Critical Care, University of MelbourneVIC, Australia |
Introduction: Some studies have reported that early administration of acetylcysteine using a 3-bag regimen may not fully prevent development of liver injury in some patients. We compared the incidence of acute liver injury (ALI) in patients receiving acetylcysteine within eight hours of ingestion between the two-bag acetylcysteine regimen (200 mg/kg over four hours, 100 mg/kg over 16 h) and the three-bag regimen (150 mg/kg over 1 h, 50 mg/kg over 4 h, 100 mg/kg over 16 h). Method: This was a retrospective cohort study of the two-bag and three-bag acetylcysteine regimens from Monash Health, Victoria, Australia (2009–2020), compared to the three-bag acetylcysteine regimen data from the Canadian Acetaminophen Overdose Study (CAOS) database (1980–2005). The inclusion criteria included patients with an acute single ingestion of paracetamol; normal aminotransferases on presentation and acetylcysteine administered within eight hours post-overdose. The primary outcome was development of ALI (defined as: peak aminotransferase >150 IU/L). Results: At Monash Health, 191 patients were treated with the two-bag acetylcysteine regimen, and 180 patients with the three-bag regimen. The CAOS cohort provided 515 patients treated with the three-bag regimen. ALI developed in 1.6% (3/191) of the two-bag Monash Health group, 2.2% (4/180) of the three-bag Monash Health group (difference −0.6%, p 0.7), and 2.9% (15/515) of the three-bag CAOS group (difference compared to two-bag −1.3%, p 0.4). Hepatotoxicity (ALT >1000) developed in 0.5% (1/191) of patients treated with the two-bag regimen, 1.7% (3/180) in the Monash Health three-bag regimen and 1% (5/515) of the three-bag CAOS group. There were no statistically significant differences between groups. Conclusions: ALI and hepatotoxicity were observed in a small, comparable percentage of patients despite early acetylcysteine administration using the two-bag and three-bag regimens. Repeating blood tests at the end of acetylcysteine treatment will identify these patients and indicate those requiring continuation of acetylcysteine. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
Acetaminophen; acute liver injury; hepatotoxicity |
|
Taylor and Francis Ltd. |
15563650 |
|
|
Article |
Q2 |
840 |
5641 |
|
|
671 |
Irawan C., Rachman A., Rahman P., Mansjoer A. |
28767651600;15056701600;57336745700;24335647800; |
Role of Pretreatment Hemoglobin-to-Platelet Ratio in Predicting Survival Outcome of Locally Advanced Nasopharyngeal Carcinoma Patients |
2021 |
Journal of Cancer Epidemiology |
2021 |
|
1103631 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118993816&doi=10.1155%2f2021%2f1103631&partnerID=40&md5=82e487803fe00d9c97bbac4301d585e1 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology Unit, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Irawan, C., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahman, P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mansjoer, A., Clinical Epidemiology Unit, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. The three-year survival rate of locally advanced nasopharyngeal carcinoma (NPC) patients in Indonesia is lower than in other Asian countries. Calculation of hemoglobin-to-platelet ratio (HPR) may become a more practical predictor than the ratios using leukocyte cell components. Yet, no study has been conducted to investigate the potential of HPR in predicting survival outcomes in locally advanced nasopharyngeal cancer patients. Objective. To determine the role of pretreatment hemoglobin-to-platelet ratio in predicting the three-year overall survival (OS) of locally advanced NPC. Method. A retrospective cohort study followed up on 289 locally advanced NPC patients who had undergone therapy at the Dr. Cipto Mangunkusumo National General Hospital between January 2012 and October 2016. HPR cut-off was determined using ROC. Subjects were classified into two groups according to the HPR value. Kaplan-Meier curve was utilized to illustrate patients' three-year survival, and Cox regression test analyzed confounding variables to yield an adjusted hazard ratio (HR). Results. The optimal cut-off for HPR was 0.362 (AUC 0.6228, 95% CI: 0.56-0.69, sensitivity 61.27%, specificity 60.34%). Of the subjects, 48.44% had HPR≤0.362, and they had a higher three-year mortality rate than those with HPR>0.362 (50% vs. 31.54%). In bivariate analysis, HPR≤0.362 and age≥60 significantly showed a worse three-year OS (p value = 0.003 and 0.075, respectively). In multivariate analysis, we concluded that a pretreatment HPR≤0.362 was an independent negative predictor of three-year OS in locally advanced NPC patients (adjusted HR 1.82; 95% CI: 1.25-2.65). Conclusion. Pretreatment HPR≤0.362 was a negative predictor of three-year OS in locally advanced nasopharyngeal cancer patients. © 2021 Cosphiadi Irawan et al. |
|
antineoplastic agent; hemoglobin; adjuvant therapy; adult; advanced cancer; area under the curve; Article; cancer chemotherapy; cancer mortality; cancer patient; cancer prognosis; cancer radiotherapy; cancer survival; clinical outcome; cohort analysis; conformal radiotherapy; controlled study; female; follow up; general hospital; hematological parameters; hemoglobin blood level; hemoglobin to platelet ratio; human; human cell; intensity modulated radiation therapy; locally advanced nasopharyngeal carcinoma; major clinical study; male; middle aged; multiple cycle treatment; nasopharynx carcinoma; neoadjuvant chemotherapy; nutritional status; overall survival; platelet count; receiver operating characteristic; reference value; retrospective study; sensitivity and specificity; survival predic |
Hindawi Limited |
16878558 |
|
|
Article |
Q2 |
783 |
6201 |
|
|
672 |
Tunjungputri R.N., Tetrasiwi E.N., Veronica M., Pandelaki J., Ibrahim F., Nelwan E.J. |
56342194400;57267704700;57268337000;35759266900;54886001500;14527452900; |
Vaccine-Associated Disease Enhancement (VADE): Considerations in Postvaccination COVID-19 |
2021 |
Case Reports in Medicine |
2021 |
|
9673453 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118971098&doi=10.1155%2f2021%2f9673453&partnerID=40&md5=ddb9dd4ce5b8de10f0e4c9c43c6cd496 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Infectious Disease and Immunology Research Center - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tunjungputri, R.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tetrasiwi, E.N., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Veronica, M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pandelaki, J., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ibrahim, F., Microbiology Department, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nelwan, E.J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia, Infectious Disease and Immunology Research Center - IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction. The COVID-19 pandemic has entered a new phase with the roll-out of several vaccines worldwide at an accelerated phase. The occurrence of a more severe presentation of COVID-19 after vaccination may affect policymakers' decision-making and vaccine uptake by the public. Vaccine-associated disease enhancement (VADE) is the modified presentation of infections in individuals after having received a prior vaccination. Currently, little is known about the potential of vaccine-associated disease enhancement (VADE) following COVID-19 immunization. Case Illustration. We herewith report two patients admitted with confirmed COVID-19 pneumonia with a history of CoronaVac vaccination. The first patient with a relatively milder course of the disease had received two doses of CoronaVac, whereas the second patient with a more progressive course of the disease received only one dose before developing symptoms and being admitted to the hospital. Our observations suggest that vaccination could act in boosting the inflammatory process and reveal the previously asymptomatic COVID-19 illness. Theoretically, vaccines could induce VADE, where only suboptimal, nonprotective titers of neutralizing antibodies were produced or proinflammatory T-helper type 2 response was induced. Secondly, enhanced respiratory disease (ERD) could manifest, where pulmonary symptoms are more severe due to peribronchial monocytic and eosinophilic infiltration. Understanding VADE is important for the decision-making by the public, clinicians, and policymakers and is warranted for successful vaccination uptake. Conclusion. We report two cases of patients developing COVID-19 shortly after CoronaVac vaccination in which VADE is likely. We recommend that current vaccination strategies consider the measurement of neutralizing antibody titer as a guide in ensuring the safest strategy for mass immunization. Studies are needed to investigate the true incidence of VADE on vaccinated individuals as well as on how to differentiate between VADE and severe manifestations of COVID-19 that are unrelated to vaccination. © 2021 Rahajeng N. Tunjungputri et al. |
|
C reactive protein; coronavac; D dimer; fibrinogen; hemoglobin; neutralizing antibody; procalcitonin; adult; antibody titer; Article; asymptomatic coronavirus disease 2019; blood pressure; calcitonin blood level; case report; clinical article; coronavirus disease 2019; COVID-19 testing; electrocardiography; fibrinogen blood level; heart right bundle branch block; hemoglobin blood level; hospital admission; human; hyperglycemia; hypokalemia; hyponatremia; hypoosmolarity; inflammation; laboratory test; leukocyte count; lung examination; male; medical history; middle aged; physical examination; platelet count; protein blood level; real time polymerase chain reaction; thorax radiography; vaccination; vaccine associated disease enhancement; vaccine associated disease enhancement; young adult |
Hindawi Limited |
16879627 |
|
|
Article |
Q4 |
200 |
19317 |
|
|
676 |
Agarwal A., Sharma R.K., Gupta S., Boitrelle F., Finelli R., Parekh N., Durairajanayagam D., Saleh R., Arafa M., Cho C.L., Farkouh A., Rambhatla A., Henkel R., Vogiatzi P., Tadros N., Kavoussi P., Ko E., Leisegang K., Kandil H., Palani A., Salvio G., Mostafa T., Rajmil O., Banihani S.A., Schon S., Le T.V., Birowo P., Çeker G., Alvarez J., Molina J.M.C., Ho C.C.K., Calogero A.E., Khalafalla K., Duran M.B., Kuroda S., Colpi G.M., Zini A., Anagnostopoulou C., Pescatori E., Chung E., Caroppo E., Dimitriadis F., Pinggera G.-M., Busetto G.M., Balercia G., Elbardisi H., Taniguchi H., Park H.J., Rosas I.M., de la Rosette J., Ramsay J., Bowa K., Simopoulou M., Rodriguez M.G., Sabbaghian M., Martinez M., Gilani M.A.S., Al-Marhoon M.S., Kosgi R., Cannarella R., Micic S., Fukuhara S., Parekattil S., Jindal S., Abdel-Meguid T.A.-A., Morimoto Y., Shah R. |
7401480880;56464514400;8924915200;35306701900;57210196522;57196694810;55520166400;7006807491;23098964500;57197761284;57208753862;23398404000;16194084100;55926424800;6701691160;13805293700;54894624400;55522599700;57225096159;57195328571;57191592841;14060837800;6602414666;55393128900;36119073400;57327390400;6504153311;57445145100;7402573357;57214102315;57327957600;7006656219;57188552644;57216609982;57327256700;7004721256;7005212511;57225111834;7003338300;57327111700;6602342322;15126468500;6603547664;37049750600;56259951900;56711976600;22836833700;57327528100;57225111015;7102844406;7103327153;24721453900;6506988003;57225094450;24451370900;57214939051;57327818500;9247352000;57195955297;56033761100;7006493137;8635237400;6506341654;57214937086;6508134167;36051984500;23470471000; |
Sperm vitality and necrozoospermia: diagnosis, management, and results of a global survey of clinical practice |
2021 |
World Journal of Men's Health |
39 |
|
210149 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118736952&doi=10.5534%2fwjmh.210149&partnerID=40&md5=776ce144f9bcad4451df84b64415ccd7 |
American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States; Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France; Paris Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France; Department of Urology, Cleveland Clinic, Cleveland, OH, United States; Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia; Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt; Department of Urology, Hamad Medical Corporation, Doha, Qatar; Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar; SH Ho Urology Center, Department of Surgery, Chinese University of Hong Kong, Hong Kong; Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, United States; Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom; Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa; LogixX Pharma, Berkshire, Theale, United Kingdom; Andromed Health and Reproduction, Fertility Diagnostics Laboratory, Maroussi, Greece; Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, United States; Austin Fertility and Reproductive Medicine/Westlake IVF, Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; Department of Urology, Loma Linda University Health, Loma Linda, CA, United States; Department of Physiology, School of Natural Medicine, Faculty of Community and Health Sciences, University of the Western Cape, Bellville, South Africa; Fakih IVF Fertility Center, Abu Dhabi, United Arab Emirates; Department of Biochemistry, College of Medicine, University of Garmian, Kalar, Iraq; Department of Endocrinology and Metabolic Diseases, Polytechnic University of Marche, Ancona, Italy; Department of Andrology, Sexology and STIs, Faculty of Medicina, Cairo University, Cairo, Egypt; Department of Andrology, Fundacio Puigvert, Barcelona, Spain; Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan; Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States; Department of Andrology and Urology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam; Department of Andrology, Binh Dan Hospital, Ho Chi Minh City, Viet Nam; Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Samsun Vezirköprü State Hospital, Samsun, Turkey; Centro ANDROGEN, La Coruña, Spain; Servicio de Urología, Hospital Clínico de Barcelona, Barcelona, Spain; Department of Surgery, School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia; Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy; Department of Urology, Samsun Training and Research Hospital, Samsun, Turkey; Andrology and IVF Unit, Procrea Institute, Lugano, Switzerland; Department of Surgery, McGill University, Montreal, QC, Canada; IVF Clinic “Akeso-Embryo ART”, Athens, Greece; Andrology and Reproductive Medicine Unit, Gynepro Medical, Bologna, Italy; Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia; AndroUrology Centre, Brisbane, QLD, Australia; Reproductive and IVF Unit, Andrology Outpatients Clinic, ASL Bari, Conversano (Ba), Italy; 1st Urology Department, School of Medicine, Aristotle University, Thessaloniki, Greece; Department of Urology, Innsbruck Medical University, Innsbruck, Austria; Department of Urology and Renal Transplantation, University of Foggia, Ospedali Riuniti of Foggia, Foggia, Italy; Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan; Department of Urology, Pusan National University School of Medicine, Busan, South Korea; Medical Research Institute, Pusan National University Hospital, Busan, South Korea; Citmer Reproductive Medicine, IVF LAB, Mexico City, Mexico; Department of Urology, Medipol Mega University Hospital, Istanbul, Turkey; Department of Andrology, Hammersmith Hospital, London, United Kingdom; Department of Urology, Michael Chilufya Sata Copperbelt University School of Medicine, Ndola, Zambia; Department of Experimental Physiology, School of Health Sciences, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Departamento Docencia e Investigación, Hospital Militar Campo de Mayo, Universidad Barcelo, Buenos Aires, Argentina; Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran; Section of Urology, University of Santo Tomas Hospital, Manila, Philippines; Department of Surgery, Urology Division, Sultan Qaboos University, Muscat, Oman; Department of Urology and Andrology, AIG Hospitals, Gachibowli, Hyderabad, India; Department of Andrology, Uromedica Polyclinic, Belgrade, Serbia; Department of Urology, Graduate School of Medicine, Osaka University, Osaka, Japan; Avant Concierge Urology, University of Central Florida, Winter Garden, FL, United States; Department of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India; Department of Urology, Faculty of Medicine, Minia University, Minia, Egypt; Department of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; HORAC Grand Front Osaka Clinic, Osaka, Japan; Division of Andrology, Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India |
Agarwal, A., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States; Sharma, R.K., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States; Gupta, S., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States; Boitrelle, F., Reproductive Biology, Fertility Preservation, Andrology, CECOS, Poissy Hospital, Poissy, France, Paris Saclay University, UVSQ, INRAE, BREED, Jouy-en-Josas, France; Finelli, R., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States; Parekh, N., Department of Urology, Cleveland Clinic, Cleveland, OH, United States; Durairajanayagam, D., Department of Physiology, Faculty of Medicine, Universiti Teknologi MARA, Sungai Buloh Campus, Selangor, Malaysia; Saleh, R., Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Sohag University, Sohag, Egypt; Arafa, M., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States, Department of Urology, Hamad Medical Corporation, Doha, Qatar, Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar; Cho, C.L., SH Ho Urology Center, Department of Surgery, Chinese University of Hong Kong, Hong Kong; Farkouh, A., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States; Rambhatla, A., Department of Urology, Vattikuti Urology Institute, Henry Ford Health System, Detroit, MI, United States; Henkel, R., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States, Department of Metabolism, Digestion and Reproduction, Imperial College London, London, United Kingdom, Department of Medical Bioscience, University of the Western Cape, Bellville, South Africa, LogixX Pharma, Berkshire, Theale, United Kingdom; Vogiatzi, P., Andromed Health and Reproduction, Fertility Diagnostics Laboratory, Maroussi, Greece; Tadros, N., Division of Urology, Southern Illinois University School of Medicine, Springfield, IL, United States; Kavoussi, P., Austin Fertility and Reproductive Medicine/Westlake IVF, Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, United States; Ko, E., Department of Urology, Loma Linda University Health, Loma Linda, CA, United States; Leisegang, K., Department of Physiology, School of Natural Medicine, Faculty of Community and Health Sciences, University of the Western Cape, Bellville, South Africa; Kandil, H., Fakih IVF Fertility Center, Abu Dhabi, United Arab Emirates; Palani, A., Department of Biochemistry, College of Medicine, University of Garmian, Kalar, Iraq; Salvio, G., Department of Endocrinology and Metabolic Diseases, Polytechnic University of Marche, Ancona, Italy; Mostafa, T., Department of Andrology, Sexology and STIs, Faculty of Medicina, Cairo University, Cairo, Egypt; Rajmil, O., Department of Andrology, Fundacio Puigvert, Barcelona, Spain; Banihani, S.A., Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, Jordan University of Science and Technology, Irbid, Jordan; Schon, S., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, MI, United States; Le, T.V., Department of Andrology and Urology, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam, Department of Andrology, Binh Dan Hospital, Ho Chi Minh City, Viet Nam; Birowo, P., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Çeker, G., Department of Urology, Samsun Vezirköprü State Hospital, Samsun, Turkey; Alvarez, J., Centro ANDROGEN, La Coruña, Spain; Molina, J.M.C., Servicio de Urología, Hospital Clínico de Barcelona, Barcelona, Spain; Ho, C.C.K., Department of Surgery, School of Medicine, Faculty of Health and Medical Sciences, Taylor’s University, Subang Jaya, Malaysia; Calogero, A.E., Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy; Khalafalla, K., Department of Urology, Hamad Medical Corporation, Doha, Qatar; Duran, M.B., Department of Urology, Samsun Training and Research Hospital, Samsun, Turkey; Kuroda, S., American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, United States; Colpi, G.M., Andrology and IVF Unit, Procrea Institute, Lugano, Switzerland; Zini, A., Department of Surgery, McGill University, Montreal, QC, Canada; Anagnostopoulou, C., IVF Clinic “Akeso-Embryo ART”, Athens, Greece; Pescatori, E., Andrology and Reproductive Medicine Unit, Gynepro Medical, Bologna, Italy; Chung, E., Department of Urology, Princess Alexandra Hospital, University of Queensland, Brisbane, QLD, Australia, AndroUrology Centre, Brisbane, QLD, Australia; Caroppo, E., Reproductive and IVF Unit, Andrology Outpatients Clinic, ASL Bari, Conversano (Ba), Italy; Dimitriadis, F., 1st Urology Department, School of Medicine, Aristotle University, Thessaloniki, Greece; Pinggera, G.-M., Department of Urology, Innsbruck Medical University, Innsbruck, Austria; Busetto, G.M., Department of Urology and Renal Transplantation, University of Foggia, Ospedali Riuniti of Foggia, Foggia, Italy; Balercia, G., Department of Endocrinology and Metabolic Diseases, Polytechnic University of Marche, Ancona, Italy; Elbardisi, H., Department of Urology, Hamad Medical Corporation, Doha, Qatar, Department of Urology, Weill Cornell Medical-Qatar, Doha, Qatar; Taniguchi, H., Department of Urology and Andrology, Kansai Medical University, Hirakata, Osaka, Japan; Park, H.J., Department of Urology, Pusan National University School of Medicine, Busan, South Korea, Medical Research Institute, Pusan National University Hospital, Busan, South Korea; Rosas, I.M., Citmer Reproductive Medicine, IVF LAB, Mexico City, Mexico; de la Rosette, J., Department of Urology, Medipol Mega University Hospital, Istanbul, Turkey; Ramsay, J., Department of Andrology, Hammersmith Hospital, London, United Kingdom; Bowa, K., Department of Urology, Michael Chilufya Sata Copperbelt University School of Medicine, Ndola, Zambia; Simopoulou, M., Department of Experimental Physiology, School of Health Sciences, Faculty of Medicine, National and Kapodistrian University of Athens, Athens, Greece; Rodriguez, M.G., Departamento Docencia e Investigación, Hospital Militar Campo de Mayo, Universidad Barcelo, Buenos Aires, Argentina; Sabbaghian, M., Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran; Martinez, M., Section of Urology, University of Santo Tomas Hospital, Manila, Philippines; Gilani, M.A.S., Department of Andrology, Reproductive Biomedicine Research Center, Royan Institute for Reproductive Biomedicine, ACECR, Tehran, Iran; Al-Marhoon, M.S., Department of Surgery, Urology Division, Sultan Qaboos University, Muscat, Oman; Kosgi, R., Department of Urology and Andrology, AIG Hospitals, Gachibowli, Hyderabad, India; Cannarella, R., Department of Clinical and Experimental Medicine, University of Catania, Catania, Italy; Micic, S., Department of Andrology, Uromedica Polyclinic, Belgrade, Serbia; Fukuhara, S., Department of Urology, Graduate School of Medicine, Osaka University, Osaka, Japan; Parekattil, S., Avant Concierge Urology, University of Central Florida, Winter Garden, FL, United States; Jindal, S., Department of Andrology and Reproductive Medicine, Jindal Hospital, Meerut, India; Abdel-Meguid, T.A.-A., Department of Urology, Faculty of Medicine, Minia University, Minia, Egypt, Department of Urology, Faculty of Medicine, King Abdulaziz University, Jeddah, Saudi Arabia; Morimoto, Y., HORAC Grand Front Osaka Clinic, Osaka, Japan; Shah, R., Division of Andrology, Department of Urology, Lilavati Hospital and Research Centre, Mumbai, India |
Sperm vitality testing is a basic semen examination that has been described in the World Health Organization (WHO) Laboratory Manual for the Examination and Processing of Human Semen from its primary edition, 40 years ago. Several methods can be used to test sperm vitality, such as the eosin-nigrosin (E-N) stain or the hypoosmotic swelling (HOS) test. In the 6th (2021) edition of the WHO Laboratory Manual, sperm vitality assessment is mainly recommended if the total motility is less than 40%. Hence, a motile spermatozoon is considered alive, however, in certain conditions an immotile spermatozoon can also be alive. Therefore, the differentiation between asthenozoospermia (pathological decrease in sperm motility) and necrozoospermia (pathological decrease in sperm vitality) is important in directing further investigation and management of infertile patients. The causes leading to necrozoospermia are diverse and can either be local or general, testicular or extra-testicular. The andrological management of necrozoospermia depends on its etiology. However, there is no standardized treatment available presently and practice varies among clinicians. In this study, we report the results of a global survey to understand current practices regarding the physician order of sperm vitality tests as well as the management practices for necrozoospermia. Laboratory and clinical scenarios are presented to guide the reader in the management of necrozoospermia with the overall objective of establishing a benchmark ranging from the diagnosis of necrozoospermia by sperm vitality testing to its clinical management. Copyright © 2021 Korean Society for Sexual Medicine and Andrology |
Asthenozoospermia; Eosine Yellowish-(YS); Infertility; Nigrosin; Spermatozoa; Vitality |
asthenospermia; clinical practice; diagnostic procedure; ejaculation; eosin nigrosin staining; human; hypoosmotic swelling test; infertility therapy; intracytoplasmic sperm injection; male infertility; necrozoospermia; physician; quality control; Review; semen analysis; semen parameters; sperm viability; spermatozoon density; spermatozoon motility; testicular sperm extraction |
Korean Society for Sexual Medicine and Andrology |
22874208 |
|
|
Review |
#N/A |
#N/A |
#N/A |
|
|
678 |
Sulistio S., Habib H., Mulyana R.M., Albar I.A. |
57216916380;57216916669;57216915765;57216915796; |
Emergency intubation practices in a tertiary teaching hospital in Jakarta, Indonesia: A prospective observational study |
2021 |
EMA - Emergency Medicine Australasia |
|
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118592756&doi=10.1111%2f1742-6723.13890&partnerID=40&md5=f148a4a939c1e802197c4a35882c3a66 |
Emergency Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sulistio, S., Emergency Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Habib, H., Emergency Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mulyana, R.M., Emergency Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Albar, I.A., Emergency Department, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Intubation is an important competency for emergency doctors. Emergency patients are often unstable, with undifferentiated conditions. There is little time to prepare these patients prior to intubation and so ED intubation may differ from intubation in intensive care units and operating theatres. The present study aims to describe the characteristics of emergency intubation after an administrative policy change within a tertiary teaching hospital in Jakarta, allowing non-anaesthetists to perform intubation in the ED. Methods: Prospective data were collected regarding patients of all age groups who were intubated at the ED of Cipto Mangunkusumo General Hospital, Jakarta, from February 2018 to January 2019. Patient characteristics, intubation attempts, medications used, complications, and disposition were recorded in a self-reported airway registry based on the Australian and New Zealand Emergency Department Airway Registry (ANZEDAR) form. Results: During the 12-month study period, 231 patients, or 41.5% of ED intubated patients were enrolled in the study, and there were 268 intubation attempts on these enrolled patients. The first-pass success rate was 207 out of 231 patients, or 89.6%, with anaesthetist (88.9%), better than emergency doctors (55.4%). Complications were reported in 51 patients, or 22.0%, with desaturation and hypotension being the most common. Thirty-three patients, or 14.3%, died in the ED before being transferred to another unit. Conclusions: The first-pass success rate is comparable with international data. Non-anaesthetic physicians must improve their experience to achieve a favourable success rate. The data on complications highlight the need for improvement in Indonesian ED intubation practices. © 2021 Australasian College for Emergency Medicine |
airway complications; airway management; emergency medicine; rapid sequence intubation; registry |
|
John Wiley and Sons Inc |
17426731 |
|
|
Article |
Q2 |
602 |
8388 |
|
|
680 |
Sandora N., Putra M.A., Nurhayati R.W., Suwarti, Nauli R., Kusuma T.R., Fitria N.A., Ardiansyah, Muttaqin C., Makdinata W., Alwi I. |
57204103434;57215605850;55748436600;57212462722;57212478305;57222897694;57148498800;57223036386;57226442135;57223405655;15055173800; |
Characterisation of the single-cell human cardiomyocytes taken from the excess heart tissue of the right ventricular outlet in congenital heart disease |
2021 |
Cell and Tissue Banking |
|
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118214107&doi=10.1007%2fs10561-021-09970-4&partnerID=40&md5=2c4fad90958206777aa1ef5e9ea1e5ec |
Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia; Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sandora, N., Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Putra, M.A., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Nurhayati, R.W., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Suwarti, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Nauli, R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Kusuma, T.R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Fitria, N.A., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Ardiansyah, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muttaqin, C., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Makdinata, W., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Alwi, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Cardiovascular disease is the second highest cause of death across the globe. Myocardial infarction is one of the heart diseases that cause permanent impairment of the heart wall leads to heart failure. Cellular therapy might give hope to regenerate the damaged myocardium. Single cells isolated from an excess heart tissue obtained from the correction of the right ventricular hypertrophy in patients with Tetralogy of Fallot for future heart study were investigated. Methods: Once resected, the heart tissues were transported at 37 °C, in Dulbecco's Modified Eagle's medium/ DMEM (4.5 g.L−1, antibiotic–antimycotic 3x, PRP10% (v/v)), to reach the lab within 30 min, weighted and grouped into less than 500 mg and more than 1000 mg (n = 4). Each sample was digested with 250 U.mL−1 Collagenase type V and 4U.mL−1 Proteinase XXIV in the MACS™ C-tube (Milltenyi, Germany), then dissociated using the MACS™ Octo Dissociator with Heater (Milltenyi, Germany) for 60 min at 37 °C. Results: All cells isolated were rod-shaped cells; viability was up to 90%. The cell density obtained from the 500 mg group were 4,867 ± 899 cells.mg−1 tissue weight, significantly higher compared to the 1,000 mg group; had 557 ± 490 cells.mg−1 tissue weight (mean of (n = 3) ± 95% C.l). The isolated cells were analyzed using FACs BD Flowcytometer, expressed cTnT + 13.38%, PECAM-1 + /VCAM-1- 32.25%, cKit + 7.85%, ICAM + 85.53%, indicating the cardiomyocyte progenitor cells. Conclusion: Cardiomyocytes taken from the wasted heart tissue might be a candidate of cardiomyocytes source to study interventions to the heart as it contained up to 13.38% cardiomyocytes, and 32.25% of cardiac progenitor cells. Moreover, perhaps when cardiac cell therapy needs autologous cardiomyocytes, less than 500 mg tissue weight can be considered as sufficient. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
Cardiac progenitor cells; Cardiomyocyte isolation; Right ventricular resection; Tetralogy of fallot; Waste heart tissue |
|
Springer Science and Business Media B.V. |
13899333 |
|
|
Article |
Q3 |
397 |
12196 |
|
|
681 |
Purbadi S., Tjahjadi H., Purwoto G., Kusuma F., Winarto H., Utami T.W., Indarti J., Sotarduga G.E. |
6505677307;57210953454;14720170400;57192911548;54080645300;57195720528;39161587400;57226332860; |
Early gestational age placenta accreta case report: Can we avoid missed diagnosis? |
2021 |
American Journal of Case Reports |
22 |
1 |
e934168 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118201241&doi=10.12659%2fAJCR.934168&partnerID=40&md5=ad11e65742808074c47abe298cdbe9f7 |
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Pathology and Anatomy, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Obstetrics and Gynecology, University of Indonesia Dr. Cipto Mangunkusumo National Referral Hospital Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Purbadi, S., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Tjahjadi, H., Department of Pathology and Anatomy, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Purwoto, G., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Kusuma, F., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Winarto, H., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Utami, T.W., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Indarti, J., Department of Obstetrics and Gynecology, University of Indonesia Dr. Cipto Mangunkusumo National Referral Hospital Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Sotarduga, G.E., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Objective: Background: Case Reports: Conclusions: Mistake in diagnosis Placenta accreta is an abnormal invasive placenta that can be life-threatening because of the risk of hemorrhage. Its incidence has increased due to high cesarean delivery rates. Early gestational age placenta accreta is difficult to diagnose and misdiagnosis can lead to inappropriate treatment. Patient 1, a 34-year-old woman (para 2 abortus 1) with 2 previous cesarean deliveries, was referred to our department for vaginal bleeding and abdominal pain. She received 2 curettages for blighted ovum; then, ultrasound examination found uterus perforation and fluid in the Douglas cavity. Exploratory laparotomy confirmed uterine perforation, and a hysterectomy was performed. Histopathological examination revealed placenta accreta. Patient 2, a 35-year-old woman (para 3) with 3 previous cesarean deliveries, was treated at a previous hospital for vaginal bleeding and stomach enlargement. She received serial chemotherapy for gestational trophoblastic neoplasia. Ultrasound examination showed a nonhomogeneous opacity in the lower uterine corpus with color score 4. Total abdominal hysterectomy was performed, and histopathological examination revealed placenta accreta. Patient 3, a 32-year-old woman (para 2) with 2 previous cesarean deliveries, had irregular vaginal bleeding suspected as gestational trophoblastic neoplasia due to ultrasound examination and positive beta-human chorionic gonadotropin. Ultrasound and MRI examination showed enlargement with nonhomogeneous opacity, color score 4, and bridging vessels. Due to our previous experience, we suspected it was a placenta accreta and performed a hysterectomy. The histopathology result indicated placenta accreta. The key point in diagnosing placenta accreta properly is to evaluate the morphometric changes based on the structure using imaging like ultrasound. Collection and analysis of these data enables precise diagnosis in early gestational age placenta accreta. © 2021, International Scientific Information, Inc.. All rights reserved. |
Cesarean section; Diagnostic techniques, obstetrical and gynecological; Placenta accreta |
analgesic agent; antibiotic agent; methotrexate; abdominal hysterectomy; abdominal pain; abdominal swelling; adult; Article; blighted ovum; cancer chemotherapy; case report; cesarean section; choriocarcinoma; clinical article; diagnostic error; dilatation and curettage; Doppler flowmetry; echography; emergency ward; female; fever; follow up; gestational age; histopathology; hospital admission; hospital discharge; human; hypovolemic shock; hysterectomy; laparotomy; missed abortion; nuclear magnetic resonance imaging; patient referral; pelvic inflammatory disease; placenta accreta; rectouterine pouch; spontaneous abortion; spotting; treatment duration; trophoblastic tumor; uterus disease; uterus perforation; vagina bleeding; diagnostic imaging; gestational age; placenta; placenta accreta; pr |
International Scientific Information, Inc. |
19415923 |
|
34719664 |
Article |
Q3 |
247 |
16822 |
|
|
686 |
Muharam R., Febri R.R., Prabowo K.A., Bustami A., Mansur I.G. |
57191492732;57195941864;57224859187;57192888839;6603222374; |
Increased Levels of CD107a and Intracellular Cytokines in IL-2 Stimulated PBMCs from Endometriosis Patients |
2021 |
International Journal of Inflammation |
2021 |
|
5760959 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117385290&doi=10.1155%2f2021%2f5760959&partnerID=40&md5=016a37c79309194717aea380b260bb3e |
Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia; Integrated Laboratory of Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia; Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Muharam, R., Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Yasmin IVF Clinic, Dr. Cipto Mangunkusumo General Hospital, Jakarta 10430, Indonesia; Febri, R.R., Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Prabowo, K.A., Human Reproduction, Infertility, and Family Planning Research Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Bustami, A., Integrated Laboratory of Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia, Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Mansur, I.G., Master Program of Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
It has been postulated that the immune system is impaired in individuals with endometriosis, with attention directed to natural killer (NK) cells. Specifically, it has been hypothesized that altered numbers of peripheral NK cells in blood are associated with the presence of endometriotic lesions. This study aimed to evaluate the level of the peripheral NK cell surface marker CD107a in endometriosis in the presence of IL-2 stimulation. Peripheral blood mononuclear cells (PBMCs) were obtained from 7 women with endometriosis and 7 women without endometriosis. The PBMCs were divided into two groups and either treated with recombinant IL-2 or left untreated. The cytotoxic activity of the PBMCs toward target cells (K562) was evaluated. Then, both groups were cocultured for 4 days. The expressions of CD107a, TNF-α, and IFN-γ were determined using flow cytometry analysis. There was no difference in the expression of CD107a prior to IL-2 stimulation in PBMCs from women with endometriosis compared to those from women without endometriosis. However, we observed upregulation of the expression of the surface marker CD107a after treatment in the endometriosis group. In addition, there was a significant difference in CD107a expression in the endometriosis group before versus after stimulation with IL-2 (p < 0.01). We also found no difference in the production of TNF-α and IFN-γ before versus after treatment with IL-2 in either groups. The levels of CD107a were significantly enhanced in peripheral blood taken from women with endometriosis after treatment with IL-2. © 2021 R. Muharam et al. |
|
gamma interferon; interleukin 2; lysosome associated membrane protein 1; tumor necrosis factor; adult; Article; cell activation; cell culture; cell isolation; cell stimulation; clinical article; coculture; controlled study; cytokine production; cytotoxicity; endometriosis; female; flow cytometry; human; human cell; immune response; K-562 cell line; pathogenesis; peripheral blood mononuclear cell; protein expression; upregulation |
Hindawi Limited |
20908040 |
|
|
Article |
Q2 |
1106 |
3761 |
|
|
692 |
Harapan H., Fajar J.K., Supriono S., Soegiarto G., Wulandari L., Seratin F., Prayudi N.G., Dewi D.P., Monica Elsina M.T., Atamou L., Wiranata S., Aprianto D.P., Friska E., Sari Firdaus D.F., Alaidin M., Wardhani F.A., Husnah M., Hidayati N.W., Hendriyanti Y., Wardani K., Evatta A., Manugan R.A., Pradipto W., Rahmawati A., Tamara F., Mahendra A.I., Nainu F., Santoso B., Irawan Primasatya C.A., Tjionganata N., Budiman H.A. |
55844857500;56156139600;57218591523;57193717004;52464692000;57291538600;57291762600;57291994900;57291762700;57292451200;57220591122;57292451300;57291762800;57292675300;57291538700;57291315100;57194724156;57291315200;57292218900;57292909500;57292451400;57292219000;57292219100;57292675400;57192950403;57202301766;57120069200;57291762900;57291995000;57291538800;57291763000; |
The prevalence, predictors and outcomes of acute liver injury among patients with COVID-19: A systematic review and meta-analysis |
2021 |
Reviews in Medical Virology |
|
|
|
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116888408&doi=10.1002%2frmv.2304&partnerID=40&md5=8da649362695a47bd93802e3d5061df1 |
Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia; Department of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Master Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia; Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia; Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia; Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
Harapan, H., Medical Research Unit, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Tropical Disease Centre, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia, Department of Microbiology, School of Medicine, Universitas Syiah Kuala, Banda Aceh, Indonesia; Fajar, J.K., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Supriono, S., Department of Internal Medicine, Division of Gastro-Entero-Hepatology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Soegiarto, G., Department of Internal Medicine, Division of Allergy & Immunology, Universitas Airlangga, Surabaya, Indonesia; Wulandari, L., Department of Pulmonology and Respiratory Medicine, Universitas Airlangga, Surabaya, Indonesia; Seratin, F., Department of Paediatric, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Prayudi, N.G., Department of Urology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Dewi, D.P., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Monica Elsina, M.T., Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Atamou, L., Faculty of Nursing, Universitas Indonesia, Depok, Indonesia; Wiranata, S., Faculty of Medicine, Universitas Udayana, Denpasar, Indonesia; Aprianto, D.P., Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Friska, E., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Sari Firdaus, D.F., Faculty of Medicine, Universitas Indonesia, Depok, Indonesia; Alaidin, M., Department of Nursing, Faculty of Medicine, Universitas Diponegoro, Semarang, Indonesia; Wardhani, F.A., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Husnah, M., Master Program of Biology, Faculty of Mathematics and Natural Sciences, Universitas Syiah Kuala, Banda Aceh, Indonesia; Hidayati, N.W., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Hendriyanti, Y., Faculty of Medicine, Universitas Gadjah Mada, Yogyakarta, Indonesia; Wardani, K., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Evatta, A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Manugan, R.A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Pradipto, W., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Rahmawati, A., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Tamara, F., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Mahendra, A.I., Brawijaya Internal Medicine Research Centre, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Nainu, F., Faculty of Pharmacy, Hasanuddin University, Makassar, Indonesia; Santoso, B., Department of Internal Medicine, RSUD Bangil, Pasuruan, Indonesia; Irawan Primasatya, C.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Tjionganata, N., Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Budiman, H.A., Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia |
The data on the predictors and prognosis of acute liver injury (ALI) among patients in coronavirus disease 2019 (COVID-19) patients are limited. The aim of this study was to determine the prevalence, predictors and outcomes of ALI among patients with COVID-19. A systematic review was conducted up to 10 June 2021. The relevant papers were searched from PubMed, Embase, Cochrane and Web of Science, and the data were analysed using a Z test. A total of 1331 papers were identified and 16 papers consisting of 1254 COVID-19 with ALI and 4999 COVID-19 without ALI were analysed. The cumulative prevalence of ALI among patients with COVID-19 was 22.8%. Male and having low lymphocyte levels were more likely to be associated with ALI compared with female and having higher lymphocyte level, odds ratio (OR): 2.70; 95% confidence interval (CI): 2.03, 3.60 and mean difference (MD) −125; 95% CI: −207, −43, respectively. COVID-19 patients with ALI had higher risk of developing severe COVID-19 compared with those without ALI (OR: 3.61; 95% CI: 2.60, 5.02). Our findings may serve as the additional evaluation for the management of ALI in COVID-19 patients. © 2021 John Wiley & Sons Ltd. |
acute liver injury; COVID-19; outcome; predictor; prevalence |
|
John Wiley and Sons Ltd |
10529276 |
|
|
Review |
Q1 |
2060 |
1246 |
|
|
694 |
Kusmardi K., Wiyarta E., Rusdi N.K., Maulana A.M., Estuningtyas A., Sunaryo H. |
56966625300;57221521342;57211475250;57290003500;55650360200;57214674652; |
The potential of lunasin extract for the prevention of breast cancer progression by upregulating E-Cadherin and inhibiting ICAM-1 |
2021 |
F1000Research |
10 |
|
902 |
|
|
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116770885&doi=10.12688%2ff1000research.55385.1&partnerID=40&md5=c9ffe7db1754323884964582b04aceb3 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia; Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Muhammadiyah Purwakarta, KH. Ahmad Dahlan Street, Central Java, 53182, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Human Cancer Research Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Rusdi, N.K., Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia, Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Maulana, A.M., Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia, Faculty of Medicine, University of Muhammadiyah Purwakarta, KH. Ahmad Dahlan Street, Central Java, 53182, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia; Sunaryo, H., Faculty of Pharmacy and Science, Universitas Muhammadiyah Prof. DR. Hamka, Limau II Street, Jakarta, 12130, Indonesia, Doctoral Program for Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Salemba Raya Street no.6, Jakarta, 10430, Indonesia |
Background: Research in natural substances for their anticancer potential has become increasingly popular. Lunasin, a soybean protein, is known to inhibit cancer progression via various pathways. The aim of this study was to investigate the effect of Lunasin Extract (LE) on the expression of Intercellular Adhesion Molecule 1 (ICAM-1) and epithelial cadherins (E-Cadherin) in breast cancer. Methods: In this true-experimental in vivo study, 24 Sprague-Dawley rats that were induced by 7,12-Dimethylbenz[a]anthracene (DMBA), were used. Based on the therapy given, the groups were divided into, normal, positive control (PC), negative control (NC), adjuvant, curative, and preventive. Lunasin was extracted from soybean seeds of the Grobogan variety in Indonesia. Tissue samples were obtained, processed, stained with anti-ICAM-1 and anti-E-Cadherin antibodies, examined under a microscope, and quantified using H-score. The data were analyzed using ANOVA, which was then followed by Duncan's test. Results: Statistically significant difference in ICAM-1 expression was observed between the following groups: adjuvant and NC, normal and NC, PC and NC, adjuvant and preventive, normal and preventive, PC and preventive, adjuvant and curative, normal and curative, PC and curative. E-Cadherin expression was significantly different between preventive and NC, adjuvant and NC, PC and NC, normal and NC, adjuvant and curative, PC and curative, normal and curative, normal and preventive. Significant negative correlation was found between ICAM-1 and E-Cadherin [-0.616 (-0.8165; -0.283)] with p = 0.001. Conclusion: Preventive dose of LE was able to reduce ICAM-1 expression while increasing E-Cadherin expression. © 2021 Kusmardi K et al. |
Breast Cancer; Cancer Prevention; E-Cadherin; ICAM-1; Lunasin |
7,12 dimethylbenz[a]anthracene; intercellular adhesion molecule 1; lunasin; soybean protein; tamoxifen; unclassified drug; uvomorulin; cadherin; intercellular adhesion molecule 1; plant extract; soybean protein; animal experiment; animal model; animal tissue; Article; breast cancer; cancer adjuvant therapy; cancer inhibition; cancer prevention; controlled study; female; in vivo study; Indonesia; microscopy; nonhuman; plant seed; protein expression; rat; soybean; Sprague Dawley rat; statistical significance; treatment duration; upregulation; animal; neoplasm; Animals; Cadherins; Intercellular Adhesion Molecule-1; Neoplasms; Plant Extracts; Rats; Rats, Sprague-Dawley; Soybean Proteins |
F1000 Research Ltd |
20461402 |
|
34691393 |
Article |
Q1 |
1099 |
3793 |
|
|