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718 |
Umiatin U., Hadisoebroto Dilogo I., Sari P., Kusuma Wijaya S. |
57202292099;57252710600;55776482300;57253327600; |
Histological Analysis of Bone Callus in Delayed Union Model Fracture Healing Stimulated with Pulsed Electromagnetic Fields (PEMF) |
2021 |
Scientifica |
2021 |
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4791172 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114651138&doi=10.1155%2f2021%2f4791172&partnerID=40&md5=bebbcb4fbf1dcad92f29c04e06fd11bf |
Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Umiatin, U., Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia, Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hadisoebroto Dilogo, I., Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sari, P., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kusuma Wijaya, S., Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Delayed union and nonunion fractures are clinical challenges for orthopedic surgeons. The development of fracture complications, such as delayed union and nonunion fractures, is still difficult to predict. Various methods are being investigated to improve fracture healing and prevent complications in patients. There are various methods to promote fracture healing, broadly divided into biological, chemical, and physical methods. One of the most widely used physical methods to promote fracture healing is the pulsed electromagnetic field (PEMF). This study aimed to evaluate the healing process of delayed union fracture after being stimulated by PEMF. Twenty-four rats were randomly divided into two groups: the control group (n = 12) and the PEMF group (n = 12). Delayed union fracture was performed on the left femur of all rats. Subsequently, the PEMF group was given PEMF stimulus with a magnetic field intensity of 1.6 mT and a frequency of 50 Hz for 4 hours/day and 7 days/week. The fracture healing process was evaluated on days 5, 10, 18, and 28 based on the bone callus histology using safranin O fast green (SOFG) staining. The results of the histological analysis showed that bone cartilage was higher in the PEMF group than in the control group throughout the observation period. In addition, the PEMF group had less fibrous tissue at the beginning of the healing. This finding indicates PEMF stimulation has an effect on inducing osteogenesis on fracture healing and reducing the risk of delayed union. © 2021 U. Umiatin et al. |
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Hindawi Limited |
2090908X |
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Article |
Q2 |
474 |
10550 |
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720 |
Hariyanto A.D., Permata T.B.M., Gondhowiardjo S.A. |
57253039400;57197808751;6508327402; |
Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity |
2021 |
Immunological Medicine |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114605951&doi=10.1080%2f25785826.2021.1975228&partnerID=40&md5=dee345614c66584e8dcc9d94211b7f1f |
Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Hariyanto, A.D., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and immune homeostasis preventing autoimmune diseases, minimalize chronic inflammatory diseases by enlisting various immunoregulatory mechanisms. The balance between effector T cells (Teff) and regulator T cells is crucial in determining the outcome of an immune response. Regarding tumors, activation or expansion of TReg cells reduces anti-tumor immunity. TReg cells inhibit the activation of CD4+ and CD8+ T cells and suppress anti-tumor activity in the tumor microenvironment. In addition, TReg cells also promote tumor angiogenesis both directly and indirectly to ensure oxygen and nutrient transport to the tumor. There is accumulating evidence showing a positive result that removing or suppressing TReg cells increases anti-tumor immune response. However, depletion of TReg cells will cause autoimmunity. One strategy to improve or restore tumor immunity is targeted therapy on the dominant effector TReg cells in tumor tissue. Various molecules such as CTLA-4, CD4, CD25, GITR, PD-1, OX40, ICOS are in clinical trials to assess their role in attenuating TReg cells’ function. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Japanese Society of Clinical Immunology. |
anti-tumor immunity; immunotherapy; regulatory T cells; TReg; TReg-targeting therapy |
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Taylor and Francis Ltd. |
25785826 |
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Review |
Q3 |
419 |
11666 |
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721 |
Rahyussalim A.J., Nugroho A., Zufar M.L.L., Fathurrahman I., Kurniawati T. |
55212166100;57211502355;57216349850;57252957500;55213290600; |
Integration of Umbilical Cord Mesenchymal Stem Cell Application in Hydroxyapatite-Based Scaffolds in the Treatment of Vertebral Bone Defect due to Spondylitis Tuberculosis: A Translational Study |
2021 |
Stem Cells International |
2021 |
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9928379 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114598250&doi=10.1155%2f2021%2f9928379&partnerID=40&md5=4e40b6a1b5d793e962718a6b68d67fa0 |
Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nugroho, A., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zufar, M.L.L., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fathurrahman, I., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurniawati, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Vertebral bone defect represents one of the most commonly found skeletal problems in the spine. Progressive increase of vertebral involvement of skeletal tuberculosis (TB) is reported as the main cause, especially in developed countries. Conventional spinal fusion using bone graft has been associated with donor-site morbidity and complications. We reported the utilization of umbilical cord mesenchymal stem cells (UC-MSCs) combined with hydroxyapatite (HA) based scaffolds in treating vertebral bone defect due to spondylitis tuberculosis. Materials and Methods. Three patients with tuberculous spondylitis in the thoracic, thoracolumbar, or lumbar region with vertebral body collapse of more than 50 percent were included. The patient underwent a 2-stage surgical procedure, consisting of debridement, decompression, and posterior stabilization in the first stage followed by anterior fusion using the lumbotomy approach at the second stage. Twenty million UC-MSCs combined with HA granules in 2 cc of saline were transplanted to fill the vertebral bone defect. Postoperative alkaline phosphatase level, quality of life, and radiological healing were evaluated at one-month, three-month, and six-month follow-up. Results. The initial mean ALP level at one-month follow-up was 48.33±8.50 U/L. This value increased at the three-month follow-up but decreased at the six-month follow-up time, 97±8.19 U/L and 90.33±4.16 U/L, respectively. Bone formation of 50-75% of the defect site with minimal fracture line was found. Increased bone formation comprising 75-100% of the total bone area was reported six months postoperation. A total score of the SF-36 questionnaire showed better progression in all 8 domains during the follow-up with the mean total score at six months of 2912.5±116.67 from all patients. Conclusion. Umbilical cord mesenchymal stem cells combined with hydroxyapatite-based scaffold utilization represent a prospective alternative therapy for bone formation and regeneration of vertebral bone defect due to spondylitis tuberculosis. Further clinical investigations are needed to evaluate this new alternative. © 2021 Ahmad Jabir Rahyussalim et al. |
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alkaline phosphatase; hydroxyapatite; adult; Article; bone defect; bone regeneration; clinical article; female; healing; human; male; ossification; quality of life; spinal cord decompression; spine fusion; spine stabilization; surgical approach; surgical debridement; tuberculous spondylitis; umbilical cord mesenchymal stem cell; vertebral bone defect |
Hindawi Limited |
16879678 |
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Article |
Q2 |
1205 |
3287 |
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722 |
Haifa G.Z., Wardoyo S. |
57249982200;57211106608; |
Surgical management in tetralogy of Fallot with rare unilateral pulmonary anomalies: A literature review |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114401204&doi=10.1177%2f02184923211039732&partnerID=40&md5=777078337b7532f398e346223b7685f6 |
Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Haifa, G.Z., Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Wardoyo, S., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Tetralogy of Fallot with unilateral pulmonary anomalies such as the unilateral absence of pulmonary artery or unilateral pulmonary agenesis is an extremely rare complex congenital heart anomaly. There is no established surgical algorithm for tetralogy of Fallot with concomitant unilateral pulmonary anomalies. This condition is still challenging, especially in the surgical field. In this review we also present our experiences in our center, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. This literature review aimed to discuss systematic treatment options and hoped to help the decision-making process when surgeons face these rare anomalies. © The Author(s) 2021. |
Tertralogy of Fallot; unilateral absence of pulmonary artery; unilateral pulmonary agenesis; unilateral pulmonary anomalies |
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SAGE Publications Inc. |
02184923 |
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Review |
Q3 |
203 |
19132 |
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727 |
Pratomo I.P., Noor D.R., Kusmardi K., Rukmana A., Paramita R.I., Erlina L., Fadilah F., Gayatri A., Fitriani M., Purnomo T.T.H., Ariane A., Heryanto R., Tedjo A. |
57192904477;57214096801;56966625300;35491487100;54882436900;57190181680;56966708600;57204275086;57233517300;57234248500;57210643323;23392757600;57189320451; |
Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19 |
2021 |
International Journal of Inflammation |
2021 |
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1653392 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113632856&doi=10.1155%2f2021%2f1653392&partnerID=40&md5=37c46cd8f6ff191ba785fa8abb7052a3 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia; Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rukmana, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Erlina, L., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Fadilah, F., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Gayatri, A., Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitriani, M., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Purnomo, T.T.H., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Ariane, A., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia, Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia; Tedjo, A., Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia |
Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-B within the endothelial cells and by inducing proinflammatory cytokine release. Concurrently, XO also converts the superoxide radicals into hydroxyl radicals that further induce inflammatory responses. These conditions will ultimately sum up a hyperinflammation condition commonly dubbed as cytokine storm syndrome (CSS). The expression of proinflammatory cytokines and neutrophil chemokines may be reduced by XO inhibitor, as observed in human respiratory syncytial virus (HRSV)-infected A549 cells. Our review emphasizes that XO may have an essential role as an anti-inflammation therapy for respiratory viral infection, including coronavirus disease 2019 (COVID-19). © 2021 Irandi Putra Pratomo et al. |
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allopurinol; uric acid; xanthine oxidase; airway epithelium cell; antiinflammatory activity; catalysis; coronavirus disease 2019; cytokine release; enzyme activity; human; hypoxia; immunopathology; inflammation; neutrophil; nonhuman; pathogenesis; protein function; protein targeting; Review; RNA virus infection |
Hindawi Limited |
20908040 |
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Review |
Q2 |
1106 |
3761 |
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729 |
Raharjo S.B., Mustika R., Lydia A., Yanni M., Sulastomo H., Zhuhra R.T., Atmadikoesoemah C.A. |
57017880700;57220273147;8451287200;57216309765;57204924380;57220591134;57212145127; |
Trainees' perceptions and expectations of formal academic mentoring during the COVID-19 pandemic in Indonesian cardiology residency programs |
2021 |
Journal of Educational Evaluation for Health Professions |
18 |
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19 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113295810&doi=10.3352%2fJEEHP.2021.18.19&partnerID=40&md5=7733f412708826aa1df71dcc04d870df |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia |
Raharjo, S.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lydia, A., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Yanni, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Sulastomo, H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia; Zhuhra, R.T., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Atmadikoesoemah, C.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: During medical residency programs, physicians develop their professional identities as specialists and encounter high expectations in terms of achieving competencies. The responsibilities of medical trainees include caring for patients, balancing work with personal life, and weathering stress, depression, and burnout. Formal academic mentoring programs strive to ease these burdens. The coronavirus disease 2019 (COVID-19) pandemic has altered the trainee-academic mentor relationship, and solutions are needed to address these challenges. The present study aimed to evaluate the formal academic mentoring process through trainees' perceptions and expectations of formal mentoring programs during COVID-19 in Indonesian cardiology residency programs. Methods: This cross-sectional study used a self-administered online questionnaire to capture trainees' perceptions and expectations regarding academic mentoring programs in 3 cardiology residency programs in Indonesia from October to November 2020. The questionnaire was developed before data collection. Perceptions of the existing mentoring programs were compared with expectations. Results: Responses were gathered from 169 out of 174 residents (response rate, 97.3%). Most trainees reported having direct contact with COVID-19 patients (88.82%). They stated that changes had taken place in the mode and frequency of communication with their academic advisors during the pandemic. Significant differences were found between trainees' perceptions of the existing mentoring programs and their expectations for academic mentoring programs (P<0.001). Conclusion: Despite the challenges of interacting with their academic mentors, trainees still perceived academic mentors as a vital resource. Study programs need to consider trainees' expectations when designing academic mentoring programs. © 2021, Korea Health Personnel Licensing Examination Institute (cc) This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Communication; COVID-19; Indonesia; Internship and residency; Mentoring |
cardiology; cross-sectional study; human; Indonesia; medical education; mentor; mentoring; motivation; pandemic; perception; questionnaire; Cardiology; COVID-19; Cross-Sectional Studies; Humans; Indonesia; Internship and Residency; Mentoring; Mentors; Motivation; Pandemics; Perception; SARS-CoV-2; Surveys and Questionnaires |
Korea Health Personnel Licensing Examination Institute |
19755937 |
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34399567 |
Article |
Q2 |
397 |
12204 |
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731 |
Raharjo D.E., Kunadian V. |
57212958767;55390915800; |
Is There a Difference in Efficacy of Percutaneous Coronary Intervention for Focal and Diffuse Stable Coronary Artery Disease? |
2021 |
Circulation: Cardiovascular Interventions |
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011013 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113224581&doi=10.1161%2fCIRCINTERVENTIONS.121.011013&partnerID=40&md5=d51bf48934551b00e2a6df5c69fb0e80 |
Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cardiothoracic Centre, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom |
Raharjo, D.E., Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kunadian, V., Translational and Clinical Research Institute, Newcastle University, Newcastle upon Tyne, United Kingdom, Cardiothoracic Centre, Freeman Hospital, Newcastle Upon Tyne Hospitals NHS Foundation Trust, United Kingdom |
[No abstract available] |
coronary artery disease; Editorials; heart disease; morbidity; percutaneous coronary intervention |
adverse event; coronary artery bypass graft; coronary artery disease; diagnostic imaging; human; percutaneous coronary intervention; Coronary Artery Bypass; Coronary Artery Disease; Humans; Percutaneous Coronary Intervention |
Lippincott Williams and Wilkins |
19417640 |
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34340524 |
Review |
Q1 |
2621 |
832 |
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733 |
Maulani C., C Masulili S.L., Santoso W.D., Soedarsono N., Kusdhany L., Auerkari E.I. |
57205060934;57226076327;6506080422;14049161500;55301180900;10139113000; |
Association of subgingival Epstein-Barr virus and periodontitis |
2021 |
F1000Research |
10 |
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414 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112635068&doi=10.12688%2ff1000research.52624.1&partnerID=40&md5=0f76116d02cb7eb0372cd72bb0c00912 |
Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia |
Maulani, C., Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; C Masulili, S.L., Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Santoso, W.D., Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Kusdhany, L., Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia |
Background: The Epstein-Barr virus (EBV) is gaining interest as a possible agent in the etiology of periodontitis. Previous studies have shown controversy on whether EBV DNA in the subgingival periodontal pockets is associated with periodontitis. The aim of the present study was to seek the potential relationship between EBV and periodontitis. Methods: Data on socio-demographics, oral health, and periodontal health were recorded, and samples were collected from gingival crevicular fluid, using sterile paper point. This case-control study of 118 participants included 59 subjects with severe periodontitis and 59 control subjects with mild periodontitis. The EBV load was determined by quantitative real-time PCR. Results: EBV DNA was detected in 37.3% of the case samples and in 18.6% of the control samples. There was no significant difference in the load of EBV DNA between severe and mild periodontitis (p>0.05). The observed load of EBV DNA was up to 4.55x10 5 copies/mL. The detected EBV DNA was significantly associated with the plaque index and the oral hygiene index (all p<0.05). Conclusions: A significant association was not found, but EBV might contribute to periodontitis. Gingival crevicular fluid is useful for monitoring the EBV load by the real-time PCR technique. Copyright: © 2021 Maulani C et al. |
Epstein-Barr Virus; Gingival Crevicular Fluid; Periodontitis |
virus DNA; case control study; complication; Epstein Barr virus; Epstein Barr virus infection; human; periodontitis; Case-Control Studies; DNA, Viral; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Periodontitis |
NLM (Medline) |
20461402 |
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34316360 |
Article |
Q1 |
1099 |
3793 |
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736 |
Sulaiman A.S., Gani R.A., Hasan I., Lesmana C.R.A., Kurniawan J., Jasirwan C.O.M., Kalista K.F., Nababan S.H.H., Aprilicia G., Lesmana L.A. |
57216938482;23495930300;12776850800;8977683000;57193251655;55192478000;57200425631;57205443199;57212764287;55920139300; |
Overall Survival of Hepatocellular Carcinoma Patients Underwent Radiofrequency Ablation (RFA) Treatment: a Retrospective Cohort Study from Two Referral Hospitals in Indonesia |
2021 |
Journal of Gastrointestinal Cancer |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112279138&doi=10.1007%2fs12029-021-00676-0&partnerID=40&md5=2b5f131ccaeb172f51ae448108c59f48 |
Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Digestive Disease and GI Oncology Center, Medistra, Jakarta, Indonesia |
Sulaiman, A.S., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gani, R.A., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Lesmana, C.R.A., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kurniawan, J., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Jasirwan, C.O.M., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Kalista, K.F., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nababan, S.H.H., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aprilicia, G., Hepatobiliary Division, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Lesmana, L.A., Digestive Disease and GI Oncology Center, Medistra, Jakarta, Indonesia |
Background: Radiofrequency ablation (RFA) is one of the curative modality therapies commonly used for the early stage of HCC management. Although numerous studies have reported the outcome of RFA around the world, the data regarding the usage of RFA for the early and intermediate stage of HCC remains limited. Hence, the study aimed to report the survival rate of the early and intermediate stage HCC patients who underwent RFA in two tertiary referral hospitals in Jakarta, Indonesia. Methods: A retrospective cohort study was conducted in Cipto Mangunkusumo and Medistra multicenter hospital in Jakarta, Indonesia. The patients with HCC BCLC A and B who underwent RFA treatments between January 2015 to December 2017 were recruited for the study. Baseline characteristics of patients were collected from the medical record. Survival analysis was calculated using the Kaplan Meier. p value result was obtained from the log-rank test. Sub-analysis of factors associated with the survival was also included in this study. Results: There were 62 patients enrolled in this study (32.3% were BCLC A and 67.7% were BCLC B). Forty-six out of 62 patients (74.2%) were reported to have RFA as their first line of treatment, while 12 (25.8%) were reported to have a combination of RFA and other therapy modalities. All these patients were follow-up with an average duration of 27 months. The survival rate of liver cancer due to HCC for 12 and 36 months in patients who received RFA was 82.3% and 57.8%, respectively. Moreover, BCLC staging of liver cancer and response after RFA was significantly associated with survival. Conclusion: RFA still can be used as initial modality therapy nor combination with another therapy for the early and intermediate stage of HCC. BCLC staging and response after RFA had shown to be the independent factors related to survival. © 2021, Springer Science+Business Media, LLC, part of Springer Nature. |
Early stage and intermediate stage of liver cancer; Radiofrequency ablation; Survival rate |
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Springer |
19416628 |
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Article |
Q3 |
473 |
10563 |
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739 |
Kamal A.F., Ramang D.S., Prasetyo M. |
56648996700;57195942455;57192905252; |
Thromboembolism in Malignant Musculoskeletal Tumour: A Literature Review |
2021 |
Advances in Orthopedics |
2021 |
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6678167 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111946705&doi=10.1155%2f2021%2f6678167&partnerID=40&md5=d8f7af261692ce3cb5b68127f841fbe3 |
Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ramang, D.S., Department of Orthopaedic and Traumatology, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Malignant musculoskeletal tumour may cause considerable burden to general health. The fast growth combined with the tumour characteristics and its invasion capability resulted in the poor prognosis of malignant musculoskeletal tumour. Malignant musculoskeletal tumour may cause significant disability by destroying normal tissue that plays important role in body kinematics. Thromboembolism, including deep vein thrombosis, pulmonary embolism, and other kinds of venous thromboembolism, is one of the most underestimated complications of musculoskeletal tumour. Normally, thrombosis ensues when pathologic factors overcame the body hemostatic regulatory capabilities, which will predispose the body to the formation of thrombus. Venous thromboembolism in musculoskeletal tumour may develop as a result of interaction between the tumour pathologic capabilities and its interaction with normal bodily functions. In this study, we reviewed the burden of musculoskeletal tumour and its complication on global health. Then, the review will focus on the pathologic and clinical aspect of thromboembolism in malignant musculoskeletal tumour, including pathophysiology, diagnosis, and treatment based on recent findings and literature. © 2021 Achmad Fauzi Kamal et al. |
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acetylsalicylic acid; antineoplastic agent; low molecular weight heparin; tranexamic acid; blood examination; bone metastasis; cancer chemotherapy; clinical feature; drug cost; dynamic contrast-enhanced magnetic resonance imaging; echography; global health; human; locomotor system cancer; Medline; pathophysiology; patient compliance; Review; ScienceDirect; Scopus; SpringerLink; systematic review; thromboembolism; thrombosis prevention; tumor thrombus; venous thromboembolism |
Hindawi Limited |
20903464 |
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Review |
Q2 |
681 |
7334 |
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