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704 |
Setiani R.U., Batubara E.A.D., Adiarto S., Siddiq T., Indriani S., Siahaan I.H. |
57277340700;57220786003;8603606800;57206239827;57213831064;57278163100; |
Successful Ovarian Vein Embolization of a Multiparous Woman with Pelvic Congestion Syndrome |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115934784&doi=10.1055%2fs-0041-1731272&partnerID=40&md5=3d3e2b558ea0c0ec2f0afad82a5a9503 |
Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Persahabatan Public Hospital, Jakarta, Indonesia |
Setiani, R.U., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Batubara, E.A.D., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Adiarto, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Siddiq, T., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Indriani, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Siahaan, I.H., Department of Cardiology and Vascular Medicine, Persahabatan Public Hospital, Jakarta, Indonesia |
Pelvic congestion syndrome (PCS) is a clinical syndrome supported by specific findings, such as ovarian vein's dilatation, that cause pelvic vein congestion. Although many theories are explaining the pathophysiologies of this condition, the underlying cause remains unknown. The clinical manifestations of PCS are various including chronic pelvic pain (CPP), voiding disturbances, or ureteral obstruction. Imaging modality, such as ultrasonography, computed tomography (CT scan), magnetic resonance imaging (MRI), and venography, are needed to confirm and exclude the differential diagnosis. Currently, American venous forum guidelines recommended endovascular therapy which is percutaneous embolization as the first option therapy of PCS. Here, we reported a 35-year-old woman with PCS who underwent successful percutaneous embolization therapy. © 2021. International College of Angiology. All rights reserved. |
chronic pelvic pain; multiparous woman; pelvic congestion syndrome; percutaneous embolization; venography |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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707 |
Aulia I., Mustika R., Menaldi S.L. |
57204495153;57220273147;57192918198; |
Impact of Women's Domination in Plastic Surgery Residency Program in Indonesia |
2021 |
Plastic and Reconstructive Surgery - Global Open |
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e3757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115629156&doi=10.1097%2fGOX.0000000000003757&partnerID=40&md5=de23c6b8c2c9f64536023cb3cf54a1f3 |
Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, RSCM Gedung A, Jalan Diponegoro No. 71, DKI Jakarta, Jakarta Pusat, 10430, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cluster of Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Aulia, I., Division of Plastic Reconstructive and Aesthetic Surgery, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, RSCM Gedung A, Jalan Diponegoro No. 71, DKI Jakarta, Jakarta Pusat, 10430, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Cluster of Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Menaldi, S.L., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: A shift in gender dominance from man to woman in the medical field has occurred from time to time globally, including in Indonesia's plastic surgery community. This shift may alter the education and clinical settings of plastic surgery. This study aimed to explore the effect of the phenomenon of women's dominance in plastic surgery residency programs in Indonesia. Methods: This qualitative study was conducted using a phenomenological approach on three plastic surgery residency programs in Indonesia. Academic report review, focus group discussions, and in-depth interviews of residents, lecturers, residency program managers, and alumni user groups were selected using the maximum variation sampling method. Data obtained were analyzed and processed thematically. Results: Three themes emerged based on the educational process timeline: pre-education, intra-education, and post-education. Each timeline had several themes that mutually influenced the educational process. In the pre-educational process, residents' personal characters were affected by societies' positive and negative perceptions. The working environment, impact of women's dominance, and cultural dimension affected the intra-educational process. When entering the career life, residents expected an ideal working environment and had particular workplace preferences to achieve their well-being. Conclusions: The impact of women's dominance during the educational program affected residents' daily dynamics. However, this dominance did not affect the quality of education and workloads. © 2021 Lippincott Williams and Wilkins. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
759 |
6437 |
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708 |
Fajar Marta K., Moegni F. |
57270493200;55450456100; |
Level of agreement and acceptance of the 20-Minute versus 60-Minute sanitary pad test as a method for measuring the severity of stress urinary incontinence: randomised crossover trial |
2021 |
Journal of Obstetrics and Gynaecology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115614159&doi=10.1080%2f01443615.2021.1951689&partnerID=40&md5=937e03ea21fd672e116e87581915560c |
Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University/Sanglah Hospital, Denpasar, Indonesia; Reconstructive Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Fajar Marta, K., Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University/Sanglah Hospital, Denpasar, Indonesia; Moegni, F., Reconstructive Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
We aimed to measure the level of agreement and acceptance ratio of the 20-minute versus 60-minute sanitary pad test in female patients with stress urinary incontinence (SUI). This is one-sample cross-experimental design. SUI patients at the Urogynecology Outpatient Clinic at Cipto Mangunkusumo Hospital in Jakarta, Indonesia were consecutively enrolled as participants. We first administered the 20-minute test, followed by the 60-minute test, or vice versa, within 1 week. The participants did not know the type of test performed or asked during the interview. Random Number Generator software by stattrek.com was used to determine which test was performed first for each participant. Participants were interviewed using a questionnaire at the end of each test. The 20-minute sanitary pad test exhibited a good level of agreement with the 60-minute sanitary pad test (kappa R = 0.84). Forty-two respondents (84.0%) reported that they were “satisfied” with the 20-minute sanitary pad test and eight respondents (16.0%) reported that they were “very satisfied”. There was a good agreement between the 20-minute and 60-minute sanitary pad test for assessing the severity of SUI. The 20-minute sanitary pad test achieved a relatively higher level of participant satisfaction.Impact statementWhat is already known on this subject? Patients at the Urogynecology Outpatient Clinic at Cipto Mangunkusumo Hospital have a positive acceptance in the 20-minute and 60-minute sanitary pad test for assessing the severity of SUI. What do the results of this study add? From this result, the authors considered that this method can help in assessing the severity of SUI, especially in Indonesia. What are the implications of these findings for clinical practice and/or further research? As these findings, the authors think that they might be useful as a standard of assessed the severity of SUI. This method does not harmful and easy to apply for every patient with SUI. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
agreement; Pad test; satisfaction; stress urinary incontinence |
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Taylor and Francis Ltd. |
01443615 |
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Article |
Q3 |
390 |
12371 |
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714 |
S. Sitohang I.B., Legiawati L., Suseno L.S., Safira F.D. |
56734569200;57202804484;57202804092;57261863100; |
Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review |
2021 |
Dermatology Research and Practice |
2021 |
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3085670 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115103407&doi=10.1155%2f2021%2f3085670&partnerID=40&md5=9d2fa9a3d858b06aaf4bba3cc0802e10 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
S. Sitohang, I.B., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Legiawati, L., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suseno, L.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Safira, F.D., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesis of photoaged facial skin. Low concentration is effective for superficial sun damage. Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. Some adverse effects may occur but usually resolve within weeks. Overall patients were satisfied with the treatment result. An equivalent basic skin preparation such as topical retinoic acid skin priming prior to intervention is necessary for more objective comparison. Further research studies with a larger sample size and longer follow-up period are required. This evidence suggests that TCA peeling is effective in photoaging treatment, either as monotherapy or as combination therapy with other modalities. © 2021 Irma Bernadette S. Sitohang et al. |
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melanin; trichloroacetic acid; actinic keratosis; adult; bacterial superinfection; burning sensation; chemexfoliation; cohort analysis; edema; erythema; female; human; hydration status; hyperpigmentation; hypopigmentation; male; monotherapy; outcome assessment; pain; patient satisfaction; photoaging; quality of life; randomized controlled trial (topic); Review; systematic review; treatment outcome; wrinkle |
Hindawi Limited |
16876113 |
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Review |
Q3 |
456 |
10893 |
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718 |
Umiatin U., Hadisoebroto Dilogo I., Sari P., Kusuma Wijaya S. |
57202292099;57252710600;55776482300;57253327600; |
Histological Analysis of Bone Callus in Delayed Union Model Fracture Healing Stimulated with Pulsed Electromagnetic Fields (PEMF) |
2021 |
Scientifica |
2021 |
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4791172 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114651138&doi=10.1155%2f2021%2f4791172&partnerID=40&md5=bebbcb4fbf1dcad92f29c04e06fd11bf |
Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Umiatin, U., Department of Physics, Faculty of Mathematics and Natural Science, State University of Jakarta, Jakarta, Indonesia, Doctoral Program in Biomedical Science, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Hadisoebroto Dilogo, I., Department of Orthopedic and Traumatology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sari, P., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kusuma Wijaya, S., Department of Physics, Faculty of Mathematics and Natural Science, University of Indonesia, Depok, Indonesia |
Delayed union and nonunion fractures are clinical challenges for orthopedic surgeons. The development of fracture complications, such as delayed union and nonunion fractures, is still difficult to predict. Various methods are being investigated to improve fracture healing and prevent complications in patients. There are various methods to promote fracture healing, broadly divided into biological, chemical, and physical methods. One of the most widely used physical methods to promote fracture healing is the pulsed electromagnetic field (PEMF). This study aimed to evaluate the healing process of delayed union fracture after being stimulated by PEMF. Twenty-four rats were randomly divided into two groups: the control group (n = 12) and the PEMF group (n = 12). Delayed union fracture was performed on the left femur of all rats. Subsequently, the PEMF group was given PEMF stimulus with a magnetic field intensity of 1.6 mT and a frequency of 50 Hz for 4 hours/day and 7 days/week. The fracture healing process was evaluated on days 5, 10, 18, and 28 based on the bone callus histology using safranin O fast green (SOFG) staining. The results of the histological analysis showed that bone cartilage was higher in the PEMF group than in the control group throughout the observation period. In addition, the PEMF group had less fibrous tissue at the beginning of the healing. This finding indicates PEMF stimulation has an effect on inducing osteogenesis on fracture healing and reducing the risk of delayed union. © 2021 U. Umiatin et al. |
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Hindawi Limited |
2090908X |
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Article |
Q2 |
474 |
10550 |
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720 |
Hariyanto A.D., Permata T.B.M., Gondhowiardjo S.A. |
57253039400;57197808751;6508327402; |
Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity |
2021 |
Immunological Medicine |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114605951&doi=10.1080%2f25785826.2021.1975228&partnerID=40&md5=dee345614c66584e8dcc9d94211b7f1f |
Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Hariyanto, A.D., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and immune homeostasis preventing autoimmune diseases, minimalize chronic inflammatory diseases by enlisting various immunoregulatory mechanisms. The balance between effector T cells (Teff) and regulator T cells is crucial in determining the outcome of an immune response. Regarding tumors, activation or expansion of TReg cells reduces anti-tumor immunity. TReg cells inhibit the activation of CD4+ and CD8+ T cells and suppress anti-tumor activity in the tumor microenvironment. In addition, TReg cells also promote tumor angiogenesis both directly and indirectly to ensure oxygen and nutrient transport to the tumor. There is accumulating evidence showing a positive result that removing or suppressing TReg cells increases anti-tumor immune response. However, depletion of TReg cells will cause autoimmunity. One strategy to improve or restore tumor immunity is targeted therapy on the dominant effector TReg cells in tumor tissue. Various molecules such as CTLA-4, CD4, CD25, GITR, PD-1, OX40, ICOS are in clinical trials to assess their role in attenuating TReg cells’ function. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Japanese Society of Clinical Immunology. |
anti-tumor immunity; immunotherapy; regulatory T cells; TReg; TReg-targeting therapy |
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Taylor and Francis Ltd. |
25785826 |
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Review |
Q3 |
419 |
11666 |
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721 |
Rahyussalim A.J., Nugroho A., Zufar M.L.L., Fathurrahman I., Kurniawati T. |
55212166100;57211502355;57216349850;57252957500;55213290600; |
Integration of Umbilical Cord Mesenchymal Stem Cell Application in Hydroxyapatite-Based Scaffolds in the Treatment of Vertebral Bone Defect due to Spondylitis Tuberculosis: A Translational Study |
2021 |
Stem Cells International |
2021 |
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9928379 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114598250&doi=10.1155%2f2021%2f9928379&partnerID=40&md5=4e40b6a1b5d793e962718a6b68d67fa0 |
Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nugroho, A., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zufar, M.L.L., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fathurrahman, I., Department of Orthopaedic and Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kurniawati, T., Stem Cell Medical Technology Integrated Service Unit, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Stem Cells and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background. Vertebral bone defect represents one of the most commonly found skeletal problems in the spine. Progressive increase of vertebral involvement of skeletal tuberculosis (TB) is reported as the main cause, especially in developed countries. Conventional spinal fusion using bone graft has been associated with donor-site morbidity and complications. We reported the utilization of umbilical cord mesenchymal stem cells (UC-MSCs) combined with hydroxyapatite (HA) based scaffolds in treating vertebral bone defect due to spondylitis tuberculosis. Materials and Methods. Three patients with tuberculous spondylitis in the thoracic, thoracolumbar, or lumbar region with vertebral body collapse of more than 50 percent were included. The patient underwent a 2-stage surgical procedure, consisting of debridement, decompression, and posterior stabilization in the first stage followed by anterior fusion using the lumbotomy approach at the second stage. Twenty million UC-MSCs combined with HA granules in 2 cc of saline were transplanted to fill the vertebral bone defect. Postoperative alkaline phosphatase level, quality of life, and radiological healing were evaluated at one-month, three-month, and six-month follow-up. Results. The initial mean ALP level at one-month follow-up was 48.33±8.50 U/L. This value increased at the three-month follow-up but decreased at the six-month follow-up time, 97±8.19 U/L and 90.33±4.16 U/L, respectively. Bone formation of 50-75% of the defect site with minimal fracture line was found. Increased bone formation comprising 75-100% of the total bone area was reported six months postoperation. A total score of the SF-36 questionnaire showed better progression in all 8 domains during the follow-up with the mean total score at six months of 2912.5±116.67 from all patients. Conclusion. Umbilical cord mesenchymal stem cells combined with hydroxyapatite-based scaffold utilization represent a prospective alternative therapy for bone formation and regeneration of vertebral bone defect due to spondylitis tuberculosis. Further clinical investigations are needed to evaluate this new alternative. © 2021 Ahmad Jabir Rahyussalim et al. |
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alkaline phosphatase; hydroxyapatite; adult; Article; bone defect; bone regeneration; clinical article; female; healing; human; male; ossification; quality of life; spinal cord decompression; spine fusion; spine stabilization; surgical approach; surgical debridement; tuberculous spondylitis; umbilical cord mesenchymal stem cell; vertebral bone defect |
Hindawi Limited |
16879678 |
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Article |
Q2 |
1205 |
3287 |
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722 |
Haifa G.Z., Wardoyo S. |
57249982200;57211106608; |
Surgical management in tetralogy of Fallot with rare unilateral pulmonary anomalies: A literature review |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114401204&doi=10.1177%2f02184923211039732&partnerID=40&md5=777078337b7532f398e346223b7685f6 |
Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Haifa, G.Z., Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Wardoyo, S., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Tetralogy of Fallot with unilateral pulmonary anomalies such as the unilateral absence of pulmonary artery or unilateral pulmonary agenesis is an extremely rare complex congenital heart anomaly. There is no established surgical algorithm for tetralogy of Fallot with concomitant unilateral pulmonary anomalies. This condition is still challenging, especially in the surgical field. In this review we also present our experiences in our center, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. This literature review aimed to discuss systematic treatment options and hoped to help the decision-making process when surgeons face these rare anomalies. © The Author(s) 2021. |
Tertralogy of Fallot; unilateral absence of pulmonary artery; unilateral pulmonary agenesis; unilateral pulmonary anomalies |
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SAGE Publications Inc. |
02184923 |
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Review |
Q3 |
203 |
19132 |
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727 |
Pratomo I.P., Noor D.R., Kusmardi K., Rukmana A., Paramita R.I., Erlina L., Fadilah F., Gayatri A., Fitriani M., Purnomo T.T.H., Ariane A., Heryanto R., Tedjo A. |
57192904477;57214096801;56966625300;35491487100;54882436900;57190181680;56966708600;57204275086;57233517300;57234248500;57210643323;23392757600;57189320451; |
Xanthine Oxidase-Induced Inflammatory Responses in Respiratory Epithelial Cells: A Review in Immunopathology of COVID-19 |
2021 |
International Journal of Inflammation |
2021 |
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1653392 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113632856&doi=10.1155%2f2021%2f1653392&partnerID=40&md5=37c46cd8f6ff191ba785fa8abb7052a3 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia; Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, COVID-19 Task Force-Pulmonology and Respiratory Medicine Unit, Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rukmana, A., Department of Microbiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Erlina, L., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Fadilah, F., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia; Gayatri, A., Department of Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fitriani, M., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Purnomo, T.T.H., Universitas Indonesia University Hospital, Universitas Indonesia, Depok, Indonesia; Ariane, A., Division of Rheumatology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Ipb University, Bogor, Indonesia, Tropical Biopharmaca Research Center, Ipb University, Bogor, Indonesia; Tedjo, A., Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Dki Jakarta, Depok, Indonesia |
Xanthine oxidase (XO) is an enzyme that catalyzes the production of uric acid and superoxide radicals from purine bases: hypoxanthine and xanthine and is also expressed in respiratory epithelial cells. Uric acid, which is also considered a danger associated molecule pattern (DAMP), could trigger a series of inflammatory responses by activating the inflammasome complex path and NF-B within the endothelial cells and by inducing proinflammatory cytokine release. Concurrently, XO also converts the superoxide radicals into hydroxyl radicals that further induce inflammatory responses. These conditions will ultimately sum up a hyperinflammation condition commonly dubbed as cytokine storm syndrome (CSS). The expression of proinflammatory cytokines and neutrophil chemokines may be reduced by XO inhibitor, as observed in human respiratory syncytial virus (HRSV)-infected A549 cells. Our review emphasizes that XO may have an essential role as an anti-inflammation therapy for respiratory viral infection, including coronavirus disease 2019 (COVID-19). © 2021 Irandi Putra Pratomo et al. |
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allopurinol; uric acid; xanthine oxidase; airway epithelium cell; antiinflammatory activity; catalysis; coronavirus disease 2019; cytokine release; enzyme activity; human; hypoxia; immunopathology; inflammation; neutrophil; nonhuman; pathogenesis; protein function; protein targeting; Review; RNA virus infection |
Hindawi Limited |
20908040 |
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Review |
Q2 |
1106 |
3761 |
|
|
729 |
Raharjo S.B., Mustika R., Lydia A., Yanni M., Sulastomo H., Zhuhra R.T., Atmadikoesoemah C.A. |
57017880700;57220273147;8451287200;57216309765;57204924380;57220591134;57212145127; |
Trainees' perceptions and expectations of formal academic mentoring during the COVID-19 pandemic in Indonesian cardiology residency programs |
2021 |
Journal of Educational Evaluation for Health Professions |
18 |
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19 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113295810&doi=10.3352%2fJEEHP.2021.18.19&partnerID=40&md5=7733f412708826aa1df71dcc04d870df |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia |
Raharjo, S.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lydia, A., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Yanni, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Sulastomo, H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia; Zhuhra, R.T., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Atmadikoesoemah, C.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: During medical residency programs, physicians develop their professional identities as specialists and encounter high expectations in terms of achieving competencies. The responsibilities of medical trainees include caring for patients, balancing work with personal life, and weathering stress, depression, and burnout. Formal academic mentoring programs strive to ease these burdens. The coronavirus disease 2019 (COVID-19) pandemic has altered the trainee-academic mentor relationship, and solutions are needed to address these challenges. The present study aimed to evaluate the formal academic mentoring process through trainees' perceptions and expectations of formal mentoring programs during COVID-19 in Indonesian cardiology residency programs. Methods: This cross-sectional study used a self-administered online questionnaire to capture trainees' perceptions and expectations regarding academic mentoring programs in 3 cardiology residency programs in Indonesia from October to November 2020. The questionnaire was developed before data collection. Perceptions of the existing mentoring programs were compared with expectations. Results: Responses were gathered from 169 out of 174 residents (response rate, 97.3%). Most trainees reported having direct contact with COVID-19 patients (88.82%). They stated that changes had taken place in the mode and frequency of communication with their academic advisors during the pandemic. Significant differences were found between trainees' perceptions of the existing mentoring programs and their expectations for academic mentoring programs (P<0.001). Conclusion: Despite the challenges of interacting with their academic mentors, trainees still perceived academic mentors as a vital resource. Study programs need to consider trainees' expectations when designing academic mentoring programs. © 2021, Korea Health Personnel Licensing Examination Institute (cc) This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Communication; COVID-19; Indonesia; Internship and residency; Mentoring |
cardiology; cross-sectional study; human; Indonesia; medical education; mentor; mentoring; motivation; pandemic; perception; questionnaire; Cardiology; COVID-19; Cross-Sectional Studies; Humans; Indonesia; Internship and Residency; Mentoring; Mentors; Motivation; Pandemics; Perception; SARS-CoV-2; Surveys and Questionnaires |
Korea Health Personnel Licensing Examination Institute |
19755937 |
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34399567 |
Article |
Q2 |
397 |
12204 |
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