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768 |
Midoen Y.H., Suryandari D.A., Yunaini L., Susworo R., Auerkari E.I., Freisleben H.-J. |
57197805109;6505763338;57192911515;8438653400;10139113000;7003437337; |
Epstein-Barr virus nuclear antigen-1 is useful as therapeutic efficacy marker in serum but not in saliva of nasopharyngeal cancer patients who underwent radiotherapy |
2021 |
ecancermedicalscience |
15 |
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1254 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109546581&doi=10.3332%2fECANCER.2021.1254&partnerID=40&md5=debd5ca3a84a84eabb9d16f1bf92fc2d |
Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia |
Midoen, Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Yunaini, L., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 6, Jakarta, 10430, Indonesia; Susworo, R., Department of Radiotherapy, Faculty of Medicine, Universitas Indonesia and Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro 71, Jakarta, 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia; Freisleben, H.-J., Medical Research Unit, Faculty of Medicine, Universitas Indonesia, Jalan Salemba Raya 4, Jakarta, 10430, Indonesia |
Introduction: Nasopharyngeal carcinoma (NPC) is a multifactorial disease with genetic, viral, environmental and lifestyle-related risk factors. Epstein-Barr virus (EBV) can promote the oncogenic transformation of an infected cell into malignant. EBV encodes many stimulating products including Epstein-Barr virus nuclear antigen-1 (EBNA-1) which plays a key role in the regulation of gene expression and replication of the genome in the latent period of infection. EBNA-1 in serum and tumour tissue of NPC patients correlates with NPC prognosis. Moreover, the presence of EBV DNA in serum samples from NPC patients' blood circulation can be used as an early marker in the diagnosis of NPC. Objective: The objective of this study was to find effective methods for monitoring the progress of NPC patients undergoing radiotherapy and therapeutic efficacy by observing the changes in EBV DNA in serum and saliva. Methodology: The pre-experimental design compared blood and saliva taken from a pretest and post-test group of NPC patients before and after radiation therapy. The concentration of EBV DNA was measured in the serum and saliva after amplification using quantitative polymerase chain reaction (qPCR) with compatible primers for the EBNA-1 gene. The data were statistically analysed by paired T-test. Results: Highly significant (p = 0.0001) increase in cycle threshold qPCR and decrease in the mean concentration of EBV DNA (p = 0.0001) were observed in serum samples, but no significant changes were observed in saliva. Conclusions: The results suggest that EBV DNA in serum can be used as the gold standard and a marker for monitoring the response to radiation therapy in NPC patients, whereas the examination of EBV DNA from saliva samples is not accurate and thus, not appropriate. © 2021 ecancer Global Foundation. All rights reserved. |
CT; EBNA-1; EBV DNA; NPC; QPCR |
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ecancer Global Foundation |
17546605 |
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Article |
Q3 |
708 |
7022 |
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770 |
Saroyo Y.B., Wibowo N., Irwinda R., Prijanti A.R., Yunihastuti E., Bardosono S., Krisnadi S.R., Permata P.I., Wijaya S., Santawi V.P.A. |
57164888400;15049026900;57190855256;57190863386;57221273925;21933841000;56660648900;57225151181;56685332700;57192917419; |
Oxidative Stress Induced Damage and Early Senescence in Preterm Placenta |
2021 |
Journal of Pregnancy |
2021 |
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9923761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109338598&doi=10.1155%2f2021%2f9923761&partnerID=40&md5=f6580c90345ba249ad3c787766d49062 |
Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Prijanti, A.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Yunihastuti, E., Division of Allergy Immunology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Bardosono, S., Department of Clinical Nutrition, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Indonesia; Krisnadi, S.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Padjadjaran/Dr. Hasan Sadikin General Hospital, Indonesia; Permata, P.I., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Wijaya, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia; Santawi, V.P.A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction. Senescent cells have been demonstrated to release High Mobility Group Box 1 (HMGB1) which induces labor through an inflammatory pathway. This research is aimed at demonstrating whether telomere shortening, proinflammatory HMGB1, and oxidative damage marker 8-OHdG play a role in the placenta of preterm birth in comparison to term birth. Method. A cross-sectional study on 67 full thickness of the placenta obtained from mothers with term and preterm birth. Mothers with clinical signs of infection (fever>38°C, leukocytosis>18000/μL, or abnormal vaginal discharge) and other pregnancy complications were excluded. Real-time polymerase chain reaction was performed to measure T/S ratio and ELISA quantification to measure the amount of HMGB1 and 8-OHdG. Result. A total of 34 placentas from preterm and 33 placentas from term birth were examined. Maternal characteristics were comparable between the two groups. There were no statistical difference of T/S ratio (p=0.181), HMGB1 (p=0.119), and 8-OHdG (p=0.144) between the preterm and term groups. HMGB1 was moderately correlated with 8-OHdG (r=0.314). Telomere T/S ratio of the placenta did not differ between preterm and term labor despite difference in gestational age, suggesting earlier shortening in the preterm group. It is possible that critical telomere length has been achieved in both term and preterm placenta that warrants labor through senescence process. The result of our study also showed that HMGB1 was not correlated to telomere length, due to the fact that HMGB1 is not upregulated until the critical length of telomere for senescence is exhibited. Conclusion. Similar telomere length might be exhibited due to early telomere shortening in preterm birth that mimics the term placenta. The relationship between placental telomere shortening and HMGB1 release remains to be uncovered. Further research is needed to discover the factors leading to early telomere shortening in the placenta of preterm birth. © 2021 Yudianto Budi Saroyo et al. |
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cross-sectional study; female; human; metabolism; newborn; oxidative stress; placenta; pregnancy; prematurity; telomere shortening; Cross-Sectional Studies; Female; Humans; Infant, Newborn; Oxidative Stress; Placenta; Pregnancy; Premature Birth; Telomere Shortening |
Hindawi Limited |
20902727 |
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34258068 |
Article |
Q2 |
828 |
5768 |
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771 |
Victor A.A., Violetta L., Kusumowidagdo G., Pranata R. |
57191055282;57216555090;57200641034;57201973901; |
Pars-plana vitrectomy combined with retinectomy in severe open-globe injuries: A systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109102924&doi=10.1177%2f11206721211029472&partnerID=40&md5=864797e21da1505f0aa16812f4da115e |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Zhejiang University School of Medicine, Hangzhou, China; Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Violetta, L., Zhejiang University School of Medicine, Hangzhou, China, Faculty of Medicine, Universitas Hasanuddin, Makassar, Indonesia; Kusumowidagdo, G., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Background: This review summarized prophylactic retinectomy technique and its effect on anatomic and functional outcomes in severe open globe injuries (OGIs). Methods: A comprehensive search in PubMed (MEDLINE), Embase, Scopus, and EuropePMC databases was performed up until 8 January 2020. Enrolled studies include case series, studies involving pars plana vitrectomy (PPV) combined with retinectomy in severe penetrating injuries with or without IOFB, perforating injuries, and globe ruptures. Primary outcome was best-corrected visual acuity (BCVA) ⩾20/200 at the end of the study. Secondary outcomes were the rate of proliferative retinopathy (PVR), globe survival rate and retinal reattachment rate. Results: A total of seven studies, involving 275 eyes with severe OGIs, is included in this study. Meta-analysis indicates that final BCVA ⩾20/200 was achieved in 61% (95% CI 49%–73%). Meta-regression analysis showed that improvement was inversely affected by the presence of pre-operative direct macular injury (p = 0.001) and corneal scar (p = 0.015). The proportion of pre-operative BCVA <20/200 was statistically insignificant to the final BCVA ⩾20/200 (p = 0.569). One study showed that the rate is higher in the retinectomy group than the non-retinectomy group (54% vs 11%). Meta-analysis showed that anatomical success can be achieved in 85% (95% CI 78%–91%) of the patients. Meta-regression analysis indicates that the anatomical success did not vary with age (p = 0.653), retinal detachment (p = 0.525), corneal scar (p = 0.596), and lens involvement (p = 0.450). Conclusion: Early PPV combined with retinectomy was associated with acceptable visual improvement and anatomical success. © The Author(s) 2021. |
eye injuries; open-globe injuries; proliferative vitreoretinopathy; Retinectomy; vitrectomy |
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SAGE Publications Ltd |
11206721 |
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Article |
Q2 |
790 |
6120 |
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774 |
Atmakusuma T.D., Girson R., Koesnoe S. |
57216961785;14324834100;26028015000; |
Correlations between Iron Load and CD4 in Adult Transfusion-Dependent Beta Thalassemia |
2021 |
Anemia |
2021 |
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5549503 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108909049&doi=10.1155%2f2021%2f5549503&partnerID=40&md5=86934d2b70e3a64770f20d2512ea4dfb |
Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Girson, R., Division of Hematology-Medical Oncology, Department of Internal Medicine Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia; Koesnoe, S., Division of Allergy-Immunology, Department of Internal Medicine. Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Kota Depok, Indonesia |
Background. Thalassemia is a hereditary disease, and severe anemia is the main phenotype of major thalassemia. Furthermore, the most important method in the management of this disease is red blood cell transfusion. Regular transfusions administered 1 or 2 times every month improve prognosis and survival. However, there is higher risk of infections and iron overload, especially in transfusion-dependent thalassemia (TDT). Infections are the second leading cause of death in adult TDT, after heart failure. Higher risk of infection is also influenced by multiple blood transfusions which causes alteration in immune response due to alloimmunization, transfusion-related infections, and iron overload. Meanwhile, iron overload in TDT alters both innate and specific immune responses. Furthermore, previous studies have shown the correlation between ferritin with CD4, but this has not been carried out in Indonesia. Therefore, this study aims to determine the correlations between iron overload (serum ferritin and transferrin saturation) and specific immune cells (CD4). Methods. This is a cross-sectional study, and a total number of 64 subjects were examined consecutively. Chest X-ray and blood sera were obtained. The total number of subjects was 64. The seromarkers HBsAg, anti-HCV, and anti-HIV were tested using the ELISA method. Serum ferritin and transferrin saturation was tested using ECLIA, and lymphocyte subsets were analyzed using flowcytometry. Meanwhile, the correlation between variables was determined using Spearman's test. Results. The results showed that 4.9% subjects were HBsAg positive, 10.7% were anti-HCV positive, and none were anti-HIV positive. There were 4 subjects with lung tuberculosis based on the 41 chest X-ray. Meanwhile, there was a weak negative and insignificant correlation between serum ferritin with CD4 (p=0.75; r = -0.04) and a weak positive and insignificant correlation between transferrin saturation with CD4 (p=0.133; r = 0.19). Conclusion. There were no correlations between iron overload (ferritin) and cellular immunity (CD4) in adult transfusion-dependent thalassemia. © 2021 Tubagus Djumhana Atmakusuma et al. |
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C reactive protein; ferritin; hemoglobin; hepatitis B surface antigen; hepatitis C antibody; Human immunodeficiency virus antibody; iron chelating agent; transferrin; tuberculostatic agent; adult; antibiotic therapy; antibody detection; antigen detection; Article; beta thalassemia; blood sampling; blood transfusion; CD4 lymphocyte count; cellular immunity; chronic hepatitis; coinfection; cross-sectional study; disease association; electrochemiluminescence immunoassay; enzyme linked immunosorbent assay; facies; female; ferritin blood level; flow cytometry; hemoglobin blood level; hemoglobin E-beta thalassemia; hepatitis B; hepatitis C; human; human cell; Human immunodeficiency virus infection; iron overload; leukocyte count; lung tuberculosis; lymphocyte subpopulation; major clinical study; |
Hindawi Limited |
20901267 |
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Article |
Q2 |
921 |
4948 |
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775 |
Estiasari R., Diwyacitta A., Sidik M., Rida Ariarini N.N., Sitorus F., Marwadhani S.S., Maharani K., Imran D., Arpandy R.A., Pangeran D., Hakim M. |
55240204000;57225009324;56252760000;57225009527;57208331594;57203760168;57189235094;57203976849;49361070700;57203764449;57216861859; |
Evaluation of Retinal Structure and Optic Nerve Function Changes in Multiple Sclerosis: Longitudinal Study with 1-Year Follow-Up |
2021 |
Neurology Research International |
2021 |
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5573839 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108905101&doi=10.1155%2f2021%2f5573839&partnerID=40&md5=7aaf49b7f8adca76fa739b0330ba1aff |
Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Estiasari, R., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Diwyacitta, A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sidik, M., Department of Ophtalmology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Rida Ariarini, N.N., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Sitorus, F., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Marwadhani, S.S., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Maharani, K., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Imran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Arpandy, R.A., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Pangeran, D., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Hakim, M., Department of Neurology, Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background. Multiple sclerosis (MS) is an autoimmune disease characterized by inflammation and demyelination of the central nervous system which often involves the optic nerve even though only 20% of the patients experience optic neuritis (ON). Objective. This study aims to compare the retinal structure and optic nerve function between patients with MS and healthy controls (HCs), evaluate optic nerve alterations in MS over 1-year follow-up, and analyze its correlations with disease duration, number of relapses, degree of disability, and different subtypes. Methods. This is a prospective cohort study involving 58 eyes of MS patients. Optic nerve function was evaluated with best-corrected visual acuity (BCVA), contrast sensitivity, and P100 latency, while the retinal structure was evaluated from the GCIPL and RNFL thickness measured with optical coherence tomography (OCT) and fundus photography. Results. The MS group had lower BCVA (p=0.001), contrast sensitivity (p<0.001), mean GCIPL thickness (p<0.001), and mean RNFL thickness (p<0.001) than HC. At 6 and 12 months of observations, GCIPL and RNFL (nasal quadrant) of MS patients decreased significantly (p=0.007 and p=0.004, respectively). Disease duration and the number of relapses correlated with delayed P100 latency (r = -0.61, p<0.001 and r = -0.46, p=0.02). GCIPL and RNFL in the SPMS subtype were thinner than in RRMS. Conclusions. The retinal structure and optic nerve function of MS patients are worse than those of normal individuals. GCIPL and RNFL thinning occurs at 6 and 12 months but do not correlate with disease duration, the number of relapses, and degree of disability. © 2021 Riwanti Estiasari et al. |
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Hindawi Limited |
20901852 |
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Article |
Q3 |
365 |
12980 |
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777 |
Sanjay S., Leo S.W., Au Eong K.G., Adriono G.A., Fong K.C.S., Anand K., Kadarisman R.S., Granet D.B., Mahendradas P., Shetty R., Souza S.D., Iyer S.P. |
24315097100;7004356152;7003590870;57199540275;57224986711;57205395095;6508028541;6701767974;16481136500;23478872600;57224976208;55828761800; |
Global Ophthalmology Practice Patterns during COVID-19 Pandemic and Lockdown |
2021 |
Ophthalmic Epidemiology |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108832186&doi=10.1080%2f09286586.2021.1934037&partnerID=40&md5=ba28f0a2d64e8a2f774b4efdf3e9b346 |
Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Dr Leo Adult Paediatric Eye Specialist Pte Ltd, Mount Elizabeth Medical Centre, Singapore; International Eye Cataract Retina Center, Mount Elizabeth Medical Center and Farrer Park Medical Center, Singapore; Department of Ophthalmology Visual Sciences, Khoo Teck Puat Hospital, Singapore; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia; OasisEye Specialists, Kuala Lumpur, Malaysia; Great Plains Health Callahan Cancer Center, University of Nebraska, North PlatteNE, United States; Aini Eye Clinic, Jakarta Hospital, Jakarta, Indonesia; Ratner Children’s Eye Center, Shiley Eye Institute, University of California, San Diego, United States; Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States |
Sanjay, S., Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Leo, S.W., Dr Leo Adult Paediatric Eye Specialist Pte Ltd, Mount Elizabeth Medical Centre, Singapore; Au Eong, K.G., International Eye Cataract Retina Center, Mount Elizabeth Medical Center and Farrer Park Medical Center, Singapore, Department of Ophthalmology Visual Sciences, Khoo Teck Puat Hospital, Singapore; Adriono, G.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Mangunkusumo Hospital, Jakarta, Indonesia; Fong, K.C.S., OasisEye Specialists, Kuala Lumpur, Malaysia; Anand, K., Great Plains Health Callahan Cancer Center, University of Nebraska, North PlatteNE, United States; Kadarisman, R.S., Aini Eye Clinic, Jakarta Hospital, Jakarta, Indonesia; Granet, D.B., Ratner Children’s Eye Center, Shiley Eye Institute, University of California, San Diego, United States; Mahendradas, P., Department of Uvea and Ocular Immunology, Narayana Nethralaya, Bengaluru, India; Shetty, R., Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Souza, S.D., Department of Cornea and Refractive Services, Narayana Nethralaya, Bengaluru, India; Iyer, S.P., Department of Medicine, University of Texas MD Anderson Cancer Center, Houston, TX, United States |
Aim: To assess the impact of practice patterns amongst global ophthalmologists during severe acute respiratory syndrome Coronavirus 2 (SARS Cov2) causing Corona virus disease (COVID-19) and understand the various modifications made to address emergency surgeries and practice needs. Methods: An online survey was sent to practicing ophthalmologists around the world through email, Whatsapp™ ListServ17.0™ (for pediatric ophthalmologists), WeChat™ (China) and ophthalmology associations (Indonesia, Philippines, Ireland). All queries were collected and categorized. Responses to the queries were given according to the recommendations by the Ophthalmology association. Practices ability to deal with the COVID were also classified according to country and type of access to PPE. Statistical analyses of the association between these data and queries, where appropriate were carried out. Results: One thousand nine hundred sixteen ophthalmologists were invited to participate in a survey between April 10th and April 30th, 2020 of which 1207 responded, which is a response rate of approximately 63%. The majority of respondents were from India, Indonesia, China, Singapore and the USA. Our study indicates a precipitous drop in surgical procedures with 46% (n = 538) ophthalmologists ceased to operate on their patients and almost 40% (n = 486) were doing less than 25% of their original number of surgeries. The intent to resume elective surgeries was a consideration in 41% (n = 495) after an evaluation of the situation and in consultation with professional bodies. More than 2/3 of the respondents (n = 703) made it a priority to use and mandate their patients to practice physical distancing, wearing masks, and hand dis-infection for protection to limit the spread of infection. Conclusion: This global survey provides a real-world assessment of diverse practices that were in various forms of “shut down mode” and circumstances with varying capabilities to deal with COVID. It is unprecedented that the collective wisdom for a curtailment of practice has had an enormous immediate and far reaching implications on the livelihoods of ophthalmologists, their staff, and their families. Nevertheless, ophthalmologists and their staff remain resilient and have adapted to these changes pragmatically. © 2021 Taylor & Francis Group, LLC. |
COVID19; ophthalmic surgery; outpatient consultations; PPE; telehealth |
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Taylor and Francis Ltd. |
09286586 |
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Article |
Q2 |
728 |
6800 |
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783 |
Prabowo K.A., Ellenzy G., Wijaya M.C., Kloping Y.P. |
57224859187;57224861188;57221739074;57205266766; |
Impact of Work from Home Policy during the COVID-19 Pandemic on Mental Health and Reproductive Health of Women in Indonesia |
2021 |
International Journal of Sexual Health |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108422054&doi=10.1080%2f19317611.2021.1928808&partnerID=40&md5=0d311414603955c5b93af73ca9ec0c60 |
Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Prabowo, K.A., Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Ellenzy, G., Department of Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Wijaya, M.C., Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Kloping, Y.P., Faculty of Medicine, Airlangga University, Surabaya, Indonesia |
Objectives: This study aimed to assess the impact of work from home (WFH) during the COVID-19 pandemic on the mental health and reproductive health of women in Indonesia. To the best of our knowledge, this is the first study evaluating the impact of WFH policy on said health aspects in Indonesia. Methods: We conducted an observational study with a cross-sectional approach using an online survey among premenopausal married women in Indonesia. The survey included the General Health Questionnaire (GHQ-12) for psychological distress, average sexual intercourse frequency (SIF) per week, contraception use, change of menstrual pattern, and desire for having children. To analyze the effect of WFH, the participants were divided into groups based on their WFH compliance: (1) Both couples (her and her spouse) work from home, (2) Only the wife works from home, (3) Only the husband works from home, and (4) Neither works from home. Results: 348 women were included in this study. Psychological distress occurred in 48.0% (n = 167) participants. No significant difference was found between the WFH groups (χ 2[3, N = 348] = 2.077, p =.56)). The average weekly SIF was found to be significantly fewer during WFH (T = 5014, z = −5.598, p <.001). However, only 22.7% (n = 79) participants reported the use of contraception and 52.9% (n = 196) participants still wanted to have children. Change of menstrual pattern occurred in 31.6% (n = 110) participants and were significantly correlated to psychological distress (rs =.126, p =.018). Conclusions: WFH does not aggravate the effect of the pandemic on women's mental and reproductive health in Indonesia. A significant number of them still desire to have children and contraceptive prevalence is low. © 2021 Taylor & Francis Group, LLC. |
COVID-19; mental health; pandemic; Quarantine; reproductive health |
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Routledge |
19317611 |
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Article |
Q1 |
809 |
5958 |
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784 |
Bustamam A., Sarwinda D., Paradisa R.H., Victor A.A., Yudantha A.R., Siswantining T. |
36815737800;56119401500;57221562575;57191055282;55489644900;57193446800; |
Evaluation of convolutional neural network variants for diagnosis of diabetic retinopathy |
2021 |
Communications in Mathematical Biology and Neuroscience |
2021 |
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42 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108354325&doi=10.28919%2fcmbn%2f5660&partnerID=40&md5=46f614ba3ad44a65354d6ec3e2b41ab1 |
Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Bustamam, A., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Sarwinda, D., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Paradisa, R.H., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Yudantha, A.R., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswantining, T., Department of Mathematics, Faculty of Mathematics and Natural Science, Universitas Indonesia, Depok, Indonesia |
Diabetic Retinopathy (DR) is a long-term complication of Diabetes Mellitus (DM) that impairs vision. This stage occurs in visual impairment and blindness if treated late. DR identified through scanning fundus images. A technique on classifying DR in fundus images is the deep learning approach, one of the methods of implementing machine learning. In this study, the Convolutional Neural Networks (CNN) method applied with the ResNet-50 and DenseNet-121 architectures. The data adopted in this analysis was generated from DIARETDB1, an online database containing fundus images. Then, the pre-processing stage is carried out on the fundus image to improve model performance, such as selected the green channel from the images and inverted it, converted the images into grayscale images, and applied Contrast Limited Adaptive Histogram Equalization (CLAHE) for uniform contrast in the images. The outcome of this research indicates that the ResNet-50 model is better than DenseNet-121 in detecting DR. The most reliable results from the ResNet-50 model's case testing are accuracy, precision, and recall of 95%, 98%, and 96% respectively. © 2021, SCIK Publishing Corporation. All rights reserved. |
Deep learning; Densenet; Diabetic retinopathy; Fundus image; Resnet |
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SCIK Publishing Corporation |
20522541 |
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Article |
Q4 |
189 |
20081 |
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785 |
Kartini D., Taher A., Panigoro S., Setiabudy R., Jusman S., Haryana S., Murdani A., Rustamadji P., Karisyah A., Rasyid S. |
57215490523;7005269743;56790104300;6602316235;36518792100;6507708439;57224770678;55321572200;57224765948;57224779056; |
Melatonin effect on hypoxia inducible factor-1a and clinical response in patients with oral squamous cell carcinoma receiving neoadjuvant chemotherapy: A randomized controlled trial |
2021 |
Journal of Carcinogenesis |
20 |
1 |
5 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108295574&doi=10.4103%2fjcar.JCar_19_20&partnerID=40&md5=7ba744b8de3c6ab6a11dd7b89d27e34a |
Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartini, D., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Panigoro, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusman, S., Department of Biochemistry and Molecular Genetics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Haryana, S., Department of Histology and Cell Biology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Murdani, A., Division of Gastroenterology and Hepatology, Department of Internal Medicine, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rustamadji, P., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karisyah, A., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, S., Oncology Division, Department of Surgery, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Context: Chemoresistance is a major issue in patients with locally advanced oral squamous cell carcinoma (OSCC). In this study, we evaluated the effectiveness of melatonin in conjunction with neoadjuvant chemotherapy (NC) on hypoxia-inducible factor-1α (HIF-1α) expression and clinical response in locally advanced OSCC patients. Aims: To study the effects of melatonin on HIF-1α expression and its effect on the clinical response of patients with locally advanced OSCC. Settings and Design: A randomized controlled trial was conducted, wherein patients were recruited from several hospitals in Jakarta, Indonesia. Patients were randomized into two groups using computerized block randomization. Subjects and Methods: Both groups were given NC, with treatment group receiving melatonin. Outcomes measured in this study were HIF-1α expression from tissue samples and clinical response based on the RECIST 1.1 criteria. Twenty-five patients completed the study protocol and were included in the data analysis. Statistical Analysis Used: Shapiro-Wilk test was used to test the data normality. For data with normal distribution, we conducted an independent t-test to compare between the two groups. Data with abnormal distribution were analyzed using Mann-Whitney U-test. The mean difference between the two groups was analyzed using Shapiro-Wilk normality test. Results: Our study showed a significant decrease in HIF-1α expression in the melatonin group compared to the placebo group (P < 0.05, relative risk 3.08). However, the degree of reduction of HIF-1α expression in the melatonin group did not differ significantly (P = 0.301). Conclusions: Our study showed that melatonin administered at 20 mg/day could reduce the expression of HIF-1α and residual tumor percentage, but did not affect the clinical response in OSCC patients. © 2021 Annual Reviews Inc.. All rights reserved. |
Chemoresistance; hypoxia-inducible factor-1α; melatonin; oral squamous cell carcinoma |
carboplatin; cisplatin; docetaxel; fluorouracil; hypoxia inducible factor 1alpha; melatonin; messenger RNA; placebo; adult; advanced cancer; adverse drug reaction; aged; Article; cancer combination chemotherapy; cancer patient; cancer staging; cancer tissue; clinical article; clinical outcome; comparative study; computerized block randomization; controlled study; data analysis software; double blind procedure; drowsiness; fatigue; female; headache; human; human tissue; incisional biopsy; Indonesia; Karnofsky Performance Status; male; microcapsule; mouth squamous cell carcinoma; neoadjuvant chemotherapy; parallel design; protein expression; randomization; randomized controlled trial; real time polymerase chain reaction; response evaluation criteria in solid tumors; risk factor; sleep disord |
Wolters Kluwer Medknow Publications |
09746773 |
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Article |
Q1 |
2771 |
735 |
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787 |
Rahman I.A., Rasyid N., Birowo P., Atmoko W. |
57211646827;56245069300;6504153311;57193125664; |
Effects of renal transplantation on erectile dysfunction: a systematic review and meta-analysis |
2021 |
International Journal of Impotence Research |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107770401&doi=10.1038%2fs41443-021-00419-6&partnerID=40&md5=6fab70d2b92ac45bd379994f51e6be3a |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rahman, I.A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Erectile dysfunction (ED) is a major global health burden commonly observed in patients with end-stage renal disease (ESRD). Although renal transplantation improves the problem in some patients, it persists in ≈20–50% of recipients. Studies regarding the effects of kidney transplantation on ED present contradictory findings. We performed a systematic review to summarise the effects of kidney transplantation on ED. A systematic literature search was performed across PubMed, Cochrane, and Scopus databases in April 2020. We included all prospective studies that investigated the pre and posttransplant international index of erectile function (IIEF-5) scores in recipients with ED. Data search in PubMed and Google Scholar produced 1326 articles; eight were systematically reviewed with a total of 448 subjects. Meta-analysis of IIEF-5 scores showed significant improvements between pre and post transplantation. Our findings confirm that renal transplantation improves erectile function. Furthermore, transplantation also increases testosterone level. However, the evidence is limited because of the small number of studies. Further studies are required to investigate the effects of renal transplantation on erectile function. © 2021, The Author(s). |
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Springer Nature |
09559930 |
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Article |
Q2 |
508 |
9947 |
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