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814 |
Mirtha L.T., Siagian M., Tamin T.Z., Radi B., Soemarko D.S., Prijanti A.R., Irfanuddin M., Pelana R., Mansyur M. |
57193201450;6505956355;23476060900;6603494019;57192889490;57190863386;57223257669;57202117393;37085506800; |
The formula for calculating the predicted value of cardiorespiratory endurance using a foot rest-based cardiorespiratory exercise device |
2021 |
Science Progress |
104 |
2 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105102326&doi=10.1177%2f00368504211010637&partnerID=40&md5=2c4408c0d2414931797e6357c72a1d59 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Departement of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Faculty of Sports Science, University State of Jakarta, Jakarta, Indonesia |
Mirtha, L.T., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Siagian, M., Departement of Physiology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tamin, T.Z., Departement of Medical Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radi, B., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soemarko, D.S., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prijanti, A.R., Departement of Biochemistry and Biology Molecular, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irfanuddin, M., Departement of Physiology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; Pelana, R., Faculty of Sports Science, University State of Jakarta, Jakarta, Indonesia; Mansyur, M., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
This study developed a formula for calculating the predicted VO2 max value using a prototype model of foot-based cardiorespiratory exercise. Forty sedentary workers (20 men and 20 women) were enrolled via consecutive sampling. They underwent direct measurement of VO2 max using spiroergometry as the gold standard; the predicted VO2 max value was calculated using a prototype model of foot-based cardiorespiratory exercise, which was performed on consecutive days. Multivariate linear regression analysis was used to formulate the equation for the predicted VO2 max value by including potential contributing variables: gender, body height, body weight and heart rate. Bland–Altman test was used for assessing the agreement level for the predicted VO2 max value. The equation for the predicted VO2 max value was formulated as 3.2 + 0.15 optimal exercise heart rate −5.5 sexes (0 for men, 1 for women). The agreement level for the formula was acceptable in all measurement result ranges. The formula developed in this study can be used to measure the predicted VO2 max value with an acceptable agreement level. © The Author(s) 2021. |
Cardiorespiratory endurance; level of agreement; physical exercise; physical fitness; predicted VO2 max; sedentary work; sitting workers; VO2 max |
adult; article; body height; body weight; clinical article; endurance; exercise; female; foot; gender; gold standard; heart rate; human; human experiment; human tissue; linear regression analysis; male; sitting; worker |
SAGE Publications Ltd |
00368504 |
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33913389 |
Article |
Q2 |
310 |
14499 |
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819 |
Putri A.S., Soedarsono N., Nehemia B., Atmadja D.S., Ubelaker D.H. |
57223021361;14049161500;57204102056;6507824506;7003416830; |
Age estimation of individuals aged 5–23 years based on dental development of the Indonesian population |
2021 |
Forensic Sciences Research |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104502186&doi=10.1080%2f20961790.2021.1886648&partnerID=40&md5=b3c0a614893fe57774dae608436d737a |
Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Putri, A.S., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Soedarsono, N., Department of Oral Biology, Division of Forensic Odontology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Nehemia, B., Department of Dento-Maxillofacial Radiology, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Atmadja, D.S., Department of Forensic Medicine and Medico-legal, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ubelaker, D.H., Department of Anthropology, National Museum of Natural History, Smithsonian Institution, Washington, DC, United States |
Dental development can be used to estimate age for forensic purposes. However, most of the currently available methods are less reliable for the Indonesian population due to population variability. This study presents a new method and evaluates other methods that utilize dental development to estimate the age of Indonesian people. Panoramic radiographs of 304 young Indonesian people aged 5–23 years old were analysed for deciduous tooth root resorption, permanent tooth calcification, and eruption. The extent of tooth root resorption was determined based on AlQahtani’s modified Moorrees et al. method. Tooth calcification was classified based on a modified Demirjian et al. method. Tooth eruption was evaluated based on AlQahtani’s modified Bengston system. The sequence of tooth root resorption, and permanent tooth calcification and eruption were grouped into 19 age categories (from 5–23 years old) in an atlas. The differences between males and females, between maxillary and mandibular teeth, and between right and left teeth were also analysed. There were minimal significant differences of tooth development between males and females, and between the right and left teeth (P > 0.05), while the maxillary and mandibular dental development was significantly different (P < 0.05). The newly developed atlas showed the development of the right side of maxillary and mandibular tooth of combined sex of Indonesian population. Another 34 panoramic radiographs of known-age and sex individuals from Indonesia were assessed using the newly developed Atlas of Dental Development in the Indonesian Population, Ubelaker’s Dental Development Chart, The London Atlas of Human Tooth Development and Eruption by AlQahtani, and the Age Estimation Guide-Modern Australia population by Blenkin-Taylor. Accuracy was assessed by comparing estimated age to actual chronological age using the Bland-Altmand test. Results show that the smallest range of error was found in the Atlas of Dental Development in the Indonesian Population (−0.969 to 1.210 years), followed by The London Atlas of Human Tooth Development and Eruption by AlQahtani (−2.013 to 1.990 years), the Age Estimation Guide-Modern Australia population by Blenkin-Taylor (−2.495 to 2.598 years), the Dental Development Chart by Ubelaker (−2.960 to 3.289 years). These findings show that the Atlas of Dental Development constructed in this study performs better than the other three methods and presents greater accuracy of age estimation in the Indonesian population. Key points •Dental development such as deciduous tooth root resorption, permanent tooth calcification, and tooth eruption can be used to estimate age for forensic purposes. •The development of the teeth are influenced by genetic, ethnicity, and sex, therefore an age estimation method must be constructed based on the same population. •There were minimal significant differences in tooth development between male and female, and between right and left teeth, but there was significant difference between maxillary and mandibular teeth. •The Atlas of Dental Development in the Indonesian Population constructed in this study allowed more accurate age estimation of the Indonesian sample than the other methods tested. Supplemental data for this article is available online at https://doi.org/10.1080/20961790.2021.1886648. © 2021 The Author(s). Published by Taylor & Francis Group on behalf of the Academy of Forensic Science. |
age estimation; forensic odontology; Forensic sciences; root resorption; tooth calcification; tooth eruption |
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Taylor and Francis Ltd. |
20961790 |
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Article |
Q1 |
729 |
6779 |
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820 |
Rini I.S., Gunardi A.J., Yashinta, Kevin J., Marsaulina R.P., Aryandono T., Dachlan I., Dwiprahasto I. |
57189690245;57215216664;57223006688;57223012633;57220026579;23495038400;57210391374;6506398126; |
Quality of Life in Palliative Post-mastectomy Reconstruction: Keystone versus Rotational Flap |
2021 |
Plastic and Reconstructive Surgery - Global Open |
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e3457 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104488039&doi=10.1097%2fGOX.0000000000003457&partnerID=40&md5=4e95d37965469db84b820afb28853499 |
Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Rini, I.S., Department of Plastic Surgery, Dharmais Cancer Hospital, Jalan Letjen Jend. S. Parman No. 84-86, West Jakarta, DKI Jakarta, 11420, Indonesia; Gunardi, A.J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Yashinta, Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Kevin, J., Faculty of Medicine, Universitas Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Marsaulina, R.P., Faculty of Medicine, Universitas Kristen Indonesia, Central Jakarta, DKI Jakarta, Indonesia; Aryandono, T., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dachlan, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Dwiprahasto, I., Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Background: Late stage breast cancer presents with malignant wound causing skin infiltration, pain, bleeding, and malodour, which affect quality of life (QoL). Palliative mastectomy aims to eliminate wound symptoms and requires prolonged wound care to improve QoL. This study aimed to prospectively investigate QoL differences in 2 alternative reconstructive methods: keystone flap and rotational flap. Methods: Twenty-four late stage breast cancer patients with symptoms of cancer wounds were included in this study. They were divided into 2 groups: keystone flap and rotational flap. Each patient's QoL was evaluated using EORTC QLQ-C30 and QLQ-BR23 before and 3 weeks after surgery. Results: Global health post-surgery was significantly improved compared with pre-surgery in all patients (P < 0.001), across both the keystone (P = 0.018) and rotational groups (P = 0.007). Breast symptoms post-surgery were also improved compared with pre-surgery in all patients (P = 0.035). However, when analyzed per group, breast symptoms were only improved significantly in the keystone group (P = 0.013) but not in the rotational group (P = 0.575). When compared between 2 groups, future perspective post-surgery in the keystone group [100 (0-100)] was better than the rotational group [66.7 (0-100)], (P = 0.020). Conclusions: Reconstructive surgery after mastectomy improves QoL in late stage breast cancer patients. The keystone flap is superior to the rotational flap in improving global health and breast symptoms. © 2021 Georg Thieme Verlag. All rights reserved. |
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Lippincott Williams and Wilkins |
21697574 |
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Article |
Q2 |
759 |
6437 |
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827 |
Haryanto T., Suhartanto H., Arymurthy A.M., Kusmardi K. |
57193869197;16423632300;36815724000;56966625300; |
Conditional sliding windows: An approach for handling data limitation in colorectal histopathology image classification |
2021 |
Informatics in Medicine Unlocked |
23 |
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100565 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104075953&doi=10.1016%2fj.imu.2021.100565&partnerID=40&md5=dceb8084f0a81f31189f09578a878d62 |
Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Haryanto, T., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia, Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Suhartanto, H., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Arymurthy, A.M., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Kusmardi, K., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Large amounts of data are required for the training process with a convolutional neural network (CNN) because small datasets with low variation will cause over-fitting, and the model cannot predict new data with high accuracy. Additionally, the non-availability of histopathological medical data presents an issue because without ethical permission, such data cannot be obtained easily. Therefore, this study proposes a conditional sliding window algorithm to obtain sub-sample data on images of histopathology. Two sets of original data were used, one from the Warwick dataset with dimensions of 775 × 522 pixels and the other from the Department of Pathology and Anatomy, Faculty of Medicine Universitas Indonesia. The algorithm used was inspired by the conventional sliding window method, but implemented with added conditions, such as sliding the window algorithm from the left on (x,y) pixel coordinates, thereby moving from left to right, then up to down until the entire image was covered. Consequently, the new image was produced with two dimensions: 200 × 200 and 300 × 300 pixels. However, to avoid loss of information, the 25 and 50 pixels overlap were used. In this study, CNN 7-5-7 was designed and proposed to perform the process. The conditional sliding window algorithm can produce various sub-samples depending on the image and window size. Furthermore, the images produced were used to develop a CNN and were proven to accurately predict benign and malignant tissues compared to the model from the original dataset. Moreover, the sensitivity values of the Warwick public dataset and the one generated in this study are above 0.80, which shows that the proposed CNN architecture is more stable compared to the existing methods such as AlexNet and DenseNet121. This study succeeded in solving the limitations of colorectal histopathological training data by developing a conditional sliding window algorithm. This algorithm can be applied to generate other histopathological data. Moreover, our proposed CNN 7-5-7 is the fastest architecture for training, comparable to state-of-the-art methodologies. Furthermore, the dataset was used to develop the model for colorectal cancer identification and integrated on the web-based application for further implementation. © 2021 The Authors |
Augmentation; Conditional sliding windows; Convolutional neural network; Histopathology |
Article; colorectal cancer; computer language; convolutional neural network; deep learning; diagnostic accuracy; entropy; feature extraction; histopathology; human; image processing; information processing; learning algorithm; sensitivity and specificity |
Elsevier Ltd |
23529148 |
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Article |
Q3 |
440 |
11223 |
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833 |
Kaligis F., Ismail R.I., Wiguna T., Prasetyo S., Indriatmi W., Gunardi H., Pandia V., Magdalena C.C. |
36604651700;55996895500;24367785700;56879108300;57189888041;56510252700;57208206604;57222744289; |
Mental health problems and needs among transitional-age youth in Indonesia |
2021 |
International Journal of Environmental Research and Public Health |
18 |
8 |
4046 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103933053&doi=10.3390%2fijerph18084046&partnerID=40&md5=5f79eeea8b723a621bb8c21de80ea384 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Public Health, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Padjajaran, Bandung, West Java, 40115, Indonesia |
Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Prasetyo, S., Faculty of Public Health, Universitas Indonesia, Depok, West Java, 16424, Indonesia; Indriatmi, W., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Dermatovenereology, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Gunardi, H., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Pandia, V., Department of Psychiatry, Faculty of Medicine, Universitas Padjajaran, Bandung, West Java, 40115, Indonesia; Magdalena, C.C., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
“Transitional-age youth” describes those whose ages range from 16–24 years old. In this phase, the youth face new challenges and new experiences which may increase the risk for having mental health problems, yet not very many seek help from mental health professionals. In Indone-sia, no data are available about mental health problems and the needs of transitional-age youth. This study explores common mental health problems experienced during this stage and assesses how they cope with problems and their expectations from health services. This was a cross-sectional study involving 393 Indonesians aged 16–24 years in May 2020. More than 90% of students had financial and academic difficulties and felt lonely. The most prevalent mental health problem among students was anxiety (95.4%). Most of the students, ranging from 90% to 96.4%, had positive coping strategies. However, around 50% of respondents reported self-harming and having suicidal thoughts. The results of subcategories analysis between ages and faculties were similar. Their most important expectations from mental health services included confidentiality (99.2%) and being wel-coming and friendly (99.2%). In conclusion, this study highlighted the most common problems tran-sitional-age youth experience in Indonesia. While some of them already knew how to deal with their problems, not all the participants had good coping mechanisms. Their healthcare expectations were also explored, thereby providing a useful background to revise and amend the current condi-tions. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Adolescence; Coping mechanisms; Health service expectation; Mental health needs; Mental health problems; Transitional-age youth |
academic performance; coping strategy; finance; health services; mental health; student; young population; adolescent; adult; age; anxiety; Article; automutilation; confidentiality; coping behavior; cross-sectional study; female; financial stress; health care access; health care need; health care quality; human; Indonesia; juvenile; loneliness; male; mental health; mental health service; prevalence; risk factor; school stress; suicidal ideation; transitional age youth; young adult; epidemiology; mental health service; Indonesia; Adolescent; Adult; Cross-Sectional Studies; Humans; Indonesia; Mental Health; Mental Health Services; Suicidal Ideation; Young Adult |
MDPI AG |
16617827 |
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33921344 |
Article |
Q2 |
747 |
6560 |
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840 |
Sihombing A.T., Taher A., Rodjani A., Mochtar C.A., Hakim L., Daryanto B., Danarto H.R., Umbas R. |
57218510635;7005269743;6504653529;6506558321;57200406177;57208512904;57222667970;6602634832; |
Assessing the online objective structured clinical examinations in urology qualifying exam for urology residents in Indonesia during COVID-19 time |
2021 |
MethodsX |
8 |
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101316 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103707591&doi=10.1016%2fj.mex.2021.101316&partnerID=40&md5=493809572dae72b1fbf5b2b8e4d8bf25 |
Department of Urology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Department of Urology, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Department of Urology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia |
Sihombing, A.T., Department of Urology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hakim, L., Department of Urology, Faculty of Medicine, Airlangga University, Surabaya, Indonesia; Daryanto, B., Department of Urology, Faculty of Medicine, Brawijaya University, Malang, Indonesia; Danarto, H.R., Department of Urology, Faculty of Medicine, Gadjah Mada University, Yogyakarta, Indonesia; Umbas, R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
This project aimed to assess the Online National Board of Urology Objective Structured Clinical Examination (OSCE) feasibility in evaluating candidates simultaneously from five urology training centers in Indonesia during the COVID-19 pandemic. Data were collected from two online OSCE simulation trials and the Online National Board of Urology OSCE. A self-administered questionnaire was used to assess examiners and candidates’ perception. The average final score of the Online OSCE was compared to previous face-to-face OSCE results. All candidates and examiners (100%) heard and saw clearly the audio-visual in both OSCE simulation trials. None of the candidates had a failing score on the mock exam from all stations. There was a statistically significant difference between the online OSCE and December 2019 face-to-face OSCE. The Online National Board Urology OSCE was feasible and comparable to face-to-face OSCE in evaluating urology candidates. It may be beneficial for the future OSCE method in the medical education system. • Objective Structured Clinical Examination (OSCE) which assesses a broad range of urology candidates’ high-level clinical skills, is a more valid and reliable assessment instrument than the traditional oral examination • The Online National Board of Urology OSCE method can help evaluate urology candidates, especially during the unprecedented COVID-19 pandemic © 2021 |
COVID-19 Pandemic; Online Examination; Online National Board Examination; Online National Board of Urology Objective Structured Clinical Examination (OSCE); OSCE method; Urology Examination |
academic failure; Article; audiovisual aid; clinical examination; coronavirus disease 2019; e-learning; feasibility study; human; Indonesia; medical education; objective structured clinical examination; pandemic; priority journal; resident; simulation; urology |
Elsevier B.V. |
22150161 |
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Article |
Q2 |
356 |
13209 |
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842 |
Rahyussalim A.J., Marsetio A.F., Kamal A.F., Supriadi S., Setyadi I., Pribadi P.M., Mubarok W., Kurniawati T. |
55212166100;57192180884;56648996700;16040272500;57216397660;57194227346;57208440063;55213290600; |
Synthesis, Structural Characterization, Degradation Rate, and Biocompatibility of Magnesium-Carbonate Apatite (Mg-Co3Ap) Composite and Its Potential as Biodegradable Orthopaedic Implant Base Material |
2021 |
Journal of Nanomaterials |
2021 |
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6615614 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103563575&doi=10.1155%2f2021%2f6615614&partnerID=40&md5=071473665891e53e20135fe57fd742de |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Rahyussalim, A.J., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Marsetio, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Kamal, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Central General Hospital, Jakarta, 10340, Indonesia; Supriadi, S., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Setyadi, I., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Pribadi, P.M., Department of Mechanical Engineering, Faculty of Engineering Universitas Indonesia, Jakarta, Depok, West Java, 16424, Indonesia; Mubarok, W., Division of Chemical Engineering, Department of Materials Engineering Science, Graduate School of Engineering Science, Osaka University, Toyonaka, Osaka, 560-8531, Japan; Kurniawati, T., Stem Cells and Tissues Engineering Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, 10340, Indonesia |
Suitable biomechanical properties with a degradation rate parallel to normal bone healing time are vital characteristics for biodegradable implant material in orthopaedics. Magnesium (Mg) is a natural micronutrient as well as biodegradable metal with biomechanical characteristics close to that of the human bone, while carbonate apatite (CO3Ap) is a biological apatite with good osteoconductivity which allows bone healing without forming fibrotic tissue. We fabricated a Mg-CO3Ap composite with various content ratios by powder metallurgy, various milling times (3, 5, and 7 hours) at 200 RPM, warm compaction at 300°C and pressure of 265 MPa, sintering at 550°C, holding time of 1 hour, heating rate of 5°C/minutes, and room atmosphere cooling. Specimens were successfully created and had a density comparable to that of the human bone (1.95-2.13 g/cm3). Good biocompatibility was found on Mg-10% CO3Ap composite (66.67% of viable cells). Nevertheless, its biomechanical properties and corrosion resistance were inferior to the human bone. Additionally, the materials of the composites make the surrounding environment alkaline. Interparticle consolidation and grain size were dissatisfactory due to microstructural pores presumably formed by the Mg(OH)2 layer and oxidation process during sintering. However, alkaline condition caused by the material corrosion by-product might be beneficial for bone healing and wound healing process. Modifications on fabrication parameters are needed to improve interparticle consolidation, refine grain size, improve biomechanical strength, reduce corrosion products, and improve the degradation rate. © 2021 Ahmad Jabir Rahyussalim et al. |
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Apatite; Biocompatibility; Biomechanics; Composite structures; Corrosion resistance; Degradation; Grain size and shape; Orthopedics; Powder metallurgy; Sintering; Tissue regeneration; Biodegradable implants; Biomechanical characteristics; Biomechanical properties; Fabrication parameters; Magnesium carbonate apatites; Structural characterization; Surrounding environment; Wound healing process; Magnesium metallurgy |
Hindawi Limited |
16874110 |
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Article |
Q2 |
463 |
10759 |
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845 |
Aggarwal B., Jones P.W., Yunus F., Lan L.T.T., Boonsawat W., Ismaila A., Ascioglu S. |
23007797900;26121204500;57194486277;55570089700;35608231000;15127439100;57222578443; |
Direct healthcare costs associated with management of asthma: comparison of two treatment regimens in Indonesia, Thailand and Vietnam |
2021 |
Journal of Asthma |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103248190&doi=10.1080%2f02770903.2021.1903915&partnerID=40&md5=24168d049c94d08b0ab06a00763e2d22 |
Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom; Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Value Evidence and Outcomes, GSK, Collegeville, PA, United States; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Clinical Sciences R&D, GSK, Singapore, Singapore |
Aggarwal, B., Regional Respiratory Medical Affairs, GSK, Singapore, Singapore; Jones, P.W., Global Specialty & Primary Care, GSK, Brentford, Middlesex, United Kingdom, Institute for Infection and Immunity, St George’s University of London, London, United Kingdom; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia-Persahabatan National Respiratory Center Hospital, Jakarta, Indonesia; Lan, L.T.T., Faculty of Medicine, University of Medicine and Pharmacy, Ho Chi Minh City, Viet Nam; Boonsawat, W., Division of Respiratory System, Department of Internal Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand; Ismaila, A., Value Evidence and Outcomes, GSK, Collegeville, PA, United States, Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Ascioglu, S., Clinical Sciences R&D, GSK, Singapore, Singapore |
Objective: Daily inhaled corticosteroid (ICS) and long-acting beta-2-agonist (LABA) combinations comprising either regular maintenance therapy with ICS/LABA plus as-needed short-acting beta-2-agonist (SABA) or ICS-formoterol combinations used as maintenance and reliever therapy (MART) are recommended for moderate asthma. This analysis compares the direct costs of twice-daily fluticasone propionate/salmeterol (FP/salm) and budesonide/formoterol MART in three Southeast Asian countries. Methods: A literature review identified three randomized trials in patients with asthma (≥ 12 years) comparing regular twice-daily FP/salm with as-needed SABA versus MART in moderate asthma: AHEAD (NCT00242775/17 countries/2309 patients), COMPASS (AstraZeneca study SD-039-0735/16 countries/3335 patients), and COSMOS (AstraZeneca study SD-039-0691/16 countries/2143 patients). Economic analyses, conducted from a healthcare sector perspective (medication costs + healthcare utilization costs), applied unit costs from countries where healthcare costs are publicly available: Indonesia, Thailand and Vietnam. Results are expressed in British pound sterling (GBP/patient/year). Results: Annual exacerbation rates were low and differences between treatment strategies were small (range, FP/salm: 0.31–0.38, MART: 0.24–0.25) although statistically significant in favor of MART. Total average (minimum-maximum) direct costs (in GBP/patient/year) across the three studies were £187 (£137–£284), £158 (£125–£190), and £151 (£141–£164) for those who used FP/salm, and £242 (£217–£267), £284 (£237–£340) and £266 (£224–£315) for MART in Indonesia, Thailand and Vietnam, respectively. On average, total direct costs/patient/year with FP/salm were 22.8%, 44.6% and 43.0% lower than with MART for Indonesia, Thailand and Vietnam, respectively. Conclusions: In the three countries evaluated, total treatment costs with regular twice-daily FP/salm were consistently lower than with budesonide/formoterol MART due to lower direct healthcare costs. © 2021 GlaxoSmithKline. Published with license by Taylor & Francis Group, LLC. |
healthcare utilization; ICS/LABA; maintenance therapy; medication; Southeast Asia |
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Taylor and Francis Ltd. |
02770903 |
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Article |
Q2 |
687 |
7267 |
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847 |
Atmosudigdo I.S., Lim M.A., Radi B., Henrina J., Yonas E., Vania R., Pranata R. |
57222578186;57216039756;6603494019;57218482646;57201987097;57208328436;57201973901; |
Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression |
2021 |
Clinical Medicine Insights: Endocrinology and Diabetes |
14 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103239096&doi=10.1177%2f1179551421990675&partnerID=40&md5=f2529886c6cb74cf353635e1abd100c3 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia |
Atmosudigdo, I.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Radi, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association. Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study’s main outcome is a poor composite outcome, comprising of mortality and severe COVID-19. Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P =.010; I2: 56.7%, P =.018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P =.008; I2: 57.4%, P =.029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: −0.04, P =.033), male gender (coefficient: −0.03, P =.042), and hypertension (coefficient: −0.02, P =.033), but not diabetes (coefficient: −0.24, P =.135) and cardiovascular diseases (coefficient: −0.01, P =.506). Inverted funnel-plot was relatively symmetrical. Egger’s test indicates that the pooled analysis was not statistically significant for small-study effects (P =.206). Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension. PROSPERO Registration Number: CRD42020213491 © The Author(s) 2021. |
coronavirus; COVID-19; dyslipidemia; hyperlipidemia; prognosis |
Article; comorbidity; coronavirus disease 2019; diabetes mellitus; disease association; disease severity; dyslipidemia; human; hypertension; infection risk; mortality; prevalence; prognosis; risk assessment; systematic review |
SAGE Publications Ltd |
11795514 |
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Article |
Q3 |
527 |
9598 |
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848 |
Gunardi E.R., Susilo S.A. |
57192910998;57191052854; |
Menstrual Pattern and Characteristics of One-Rod and Two-Rod Levonorgestrel Implant Users |
2021 |
Obstetrics and Gynecology International |
2021 |
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2904542 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103051337&doi=10.1155%2f2021%2f2904542&partnerID=40&md5=9c88e8c5346ee41a0b8def57849e05c1 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia; Susilo, S.A., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, Jakarta, 10430, Indonesia |
Introduction. The maternal mortality ratio (MMR) in Indonesia reaches 359 per 100,000 live births. The long-acting reversible contraceptive (LARC) method is an effective contraceptive choice for reducing MMR. The contraceptive implant is one of the LARCs that has low usage due to lack of education about the side effects. This study aims to compare the menstrual pattern and characteristics between one-rod and two-rod levonorgestrel implant users. Methods. A prospective cohort study was performed in patients at Cipto Mangunkusumo Hospital (RSCM) from March 2016 to May 2018. Subject recruitment was done by consecutive sampling. This study was conducted from March 2016 until May 2019. Statistical analysis was performed on the data using the chi-square test to determine the relationship between menstrual pattern and characteristics, and the use of one-rod or two-rod levonorgestrel implants. Results. A total of 140 subjects participated in the study, comprising 70 (50%) one-rod users and 70 (50%) two-rod users. In the first month, 32.9% one-rod users experienced amenorrhea, 22.9% experienced shortened menstrual period, 30% experienced normal menstrual period, and 14,2 % experienced lengthened menstrual period. In comparison, in the first month, 41.4% two-rod users experienced amenorrhea, 15.7% experienced shortened menstrual period, 32.9% experienced normal menstrual period, and 10% experienced lengthened menstrual period. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Conclusion. There was no significant difference in menstrual patterns and characteristics between one-rod and two-rod levonorgestrel implant users. Implications. Menstrual patterns and characteristics from levonorgestrel implants user can help clinicians to reduce discontinuation rate from the acceptors. Further research should be conducted to know other side effects aside from menstrual bleeding patterns. © 2021 Eka Rusdianto Gunardi and Sulaeman Andrianto Susilo. |
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injectable contraceptive agent; levonorgestrel; oral contraceptive agent; adult; amenorrhea; Article; body mass; breast feeding; cohort analysis; comparative study; controlled study; data analysis software; female; human; long-acting reversible contraception; major clinical study; menstrual cycle; menstruation; obesity; prospective study; underweight |
Hindawi Limited |
16879589 |
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Article |
Q2 |
648 |
7760 |
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