598 |
Lisnawati Y., Marianna Y., Rohsiswatmo R. |
57196459289;57267984800;55533574600; |
Increased levels of umbilical cord blood interleukin-6 (IL-6) and Serum C-Reactive Protein (CRP) in premature infants of Vitamin D deficient mothers [Peningkatan Kadar Interleukin-6 (IL-6) Darah Tali Pusat dan Serum C-Reactive Protein (CRP) pada Bayi Prematur Dari Ibu dengan Defisiensi Vitamin D] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
1 |
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21 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115413252&doi=10.32771%2finajog.v9i1.1397&partnerID=40&md5=15a9474083b536a9bdea004cadbfbb69 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Persahabatan Hospital; Department of Pediatric, Faculty of Medicine, Universitas Indonesia Dr., Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Lisnawati, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Persahabatan Hospital; Marianna, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Persahabatan Hospital; Rohsiswatmo, R., Department of Pediatric, Faculty of Medicine, Universitas Indonesia Dr., Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: Increased levels of inflammatory factors in newborns are often associated with lower maternal vitamin D levels. This study aimed to find out the relationship between maternal and umbilical cord vitamin D serum levels on umbilical cord Interleukin-6 (IL-6) and serum C-Reactive Protein (CRP) levels in premature infants. Methods: The study was an observational analytic, cross-sectional design in mothers who underwent preterm birth at 28-34 weeks' gestation due to premature rupture of membranes (PROM) and their infants at Dr. Cipto Mangunkusumo General Hospital (RSCM), Jakarta and Persahabatan General Hospital, Jakarta, from January 2017 to August 2018. Levels of serum vitamin D of the maternal and umbilical cord, umbilical cord IL-6 and serum CRP in premature infants were recorded. Vitamin D level was divided into deficiency (<10 ng/mL), insufficiency (10-29 ng/mL), and normal (≥30 ng/mL) groups. The relationship of vitamin D levels with IL-6 and CRP was carried out using Kruskal Wallis test. Results: A total of 70 subjects met the research criteria. Umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers were higher (20.31 pg/mL and 0.50 mg/L) compared to insufficient (3.34 pg/mL and 0.45 mg/L) and normal mothers (3.29 pg/mL and 0.30 mg/L), although not statistically significant (IL-6 p = 0.665, CRP p = 0.89). Referring to the umbilical cord blood vitamin D levels, the results were different and not as expected, in which the umbilical cord IL-6 and serum CRP levels of preterm infants in the deficiency (3.76 pg/mL and 0.35 mg/L) and insufficiency (3.37 pg/mL and 0.40 mg/L) groups were lower (IL-6) and not different (CRP) than the normal group (9.41 pg/mL and 0.40 mg/L). Conclusions: There were atendency for an increase in umbbilical cord IL-6 and serum CRP level in premature infants of Vitamin D deficient mother although these were not statistically significant. Based on the levels of vitamin D umbilical cord blood, the CRP levels in the serum of premature infants were not different, while the IL-6 levels in the deficiency and insufficiency group were lower than in the normal group. © Creative Commons Atribuição-Não Comercial 4.0 Internacional |
CRP; IL-6; Maternal Vitamin D; Umbilical cord Vitamin D |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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851 |
Yunir E., Kurniawan F., Rezaprasga E., Wijaya I.P., Suroyo I., Matondang S., Irawan C., Soewondo P. |
36520254800;57202309006;57222478699;57193731572;57204106272;57192085914;28767651600;23475336100; |
Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients |
2021 |
International Journal of Stem Cells |
14 |
1 |
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21 |
32 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102786540&doi=10.15283%2fijsc20088&partnerID=40&md5=91f35aa55f974c266100f150613cc086 |
Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kurniawan, F., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rezaprasga, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suroyo, I., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Matondang, S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Irawan, C., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Diabetes mellitus (DM) remains one of the most important risk factors for peripheral artery disease (PAD), with approximately 20% of DM patients older than 40 years old are affected with PAD. The current standard management for severe PAD is endovascular intervention with or without surgical bypass. Unfortunately, up to 40% of patients are unable to undergo these revascularization therapies due to excessive surgical risk or adverse vascular side effects. Stem cell therapy has emerged as a novel therapeutic strategy for these ‘no-option’ patients. Several types of stem cells are utilized for PAD therapy, including bone marrow mononuclear cells (BMMNC) and peripheral blood mononuclear cells (PBMNC). Many studies have reported the safety of BMMNC and PBMNC, as well as its efficacy in reducing ischemic pain, ulcer size, pain-free walking distance, ankle-brachial index (ABI), and transcutaneous oxygen pressure (TcPO2). However, the capacity to establish the efficacy of reducing major amputation rates, amputation free survival, and all-cause mortality is limited, as shown by several randomized placebo-controlled trials. The present literature review will focus on comparing safety and efficacy between BMMNC and PBMNC as cell-based management in diabetic patients with PAD who are not suitable for revascularization therapy. Copyright © 2021 by the Korean Society for Stem Cell Research |
Bone marrow mononuclear cells; Diabetes mellitus; Peripheral artery disease; Peripheral blood mononuclear cells; Stem cell therapy |
Article; autologous bone marrow transplantation; bone marrow derived mononuclear cell; clinical trial (topic); comparative effectiveness; diabetes mellitus; diabetic patient; human; patient safety; peripheral blood mononuclear cell; peripheral occlusive artery disease; stem cell transplantation |
Sungkyunkwan University |
20053606 |
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Article |
Q4 |
569 |
8885 |
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