No records
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200 |
Fadrian F., Nelwan E.J., Kurniawan J., Pohan H.T. |
57268114000;14527452900;57193251655;23474782900; |
Risk of infection with multiple pathogen in post liver transplantation patient in referral centre in Jakarta, Indonesia |
2021 |
International Journal of Antimicrobial Agents |
58 |
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21003320 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115366248&doi=10.1016%2fj.ijantimicag.2021.106421.61&partnerID=40&md5=e23afb1d78408e73580d689f6327bb02 |
Department of Internal Medicine;; Division of Tropical and Infectious Disease;; Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia |
Fadrian, F., Department of Internal Medicine;; Nelwan, E.J., Department of Internal Medicine;, Division of Tropical and Infectious Disease;; Kurniawan, J., Department of Internal Medicine;, Division of Hepatology Faculty of Medicine Universitas Indonesia, Ciptomangunkusumo Hospital, Jakarta, Indonesia; Pohan, H.T., Department of Internal Medicine;, Division of Tropical and Infectious Disease; |
[No abstract available] |
aspergillosis.; biloma; CMV; post liver transplantation infection |
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Elsevier B.V. |
09248579 |
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Article |
Q1 |
1454 |
2387 |
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201 |
Tunjungputri R.N., Tetrasiwi E.N., Rizqa T., Mulansari N.A., Harimurti K. |
56342194400;57267704700;57268337300;36519326000;23473513200; |
Parenteral and oral anticoagulant treatment for hospitalized and post-discharge patients with COVID-19: A systematic review |
2021 |
International Journal of Antimicrobial Agents |
58 |
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21003587 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115349747&doi=10.1016%2fj.ijantimicag.2021.106421.87&partnerID=40&md5=c258c13fa4bd248528cd36e04d4d4fd4 |
Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital |
Tunjungputri, R.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Tetrasiwi, E.N., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Rizqa, T., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital;; Mulansari, N.A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital; Harimurti, K., Department of Internal Medicine, Universitas Indonesia, Faculty of Medicine and Cipto Mangunkusumo National Centre General Hospital; |
[No abstract available] |
anticoagulant; COVID-19; thromboprophylaxis.; VTE |
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Elsevier B.V. |
09248579 |
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Article |
Q1 |
1454 |
2387 |
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213 |
La Distia Nora R., Putera I., Khalisha D.F., Septiana I., Sitompul R. |
56001881000;56485949000;57219417896;57219417256;8312163900; |
The diagnostic value of polymerase chain reaction for ocular tuberculosis diagnosis in relation to antitubercular therapy response: a meta-analysis |
2021 |
International Journal of Infectious Diseases |
110 |
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394 |
402 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113172042&doi=10.1016%2fj.ijid.2021.07.075&partnerID=40&md5=2517c80887d20c78446a294388261c14 |
Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands; University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia |
La Distia Nora, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia, Department of Immunology, Erasmus Medical Center, Rotterdam, Netherlands, University of Indonesia Hospital (RSUI), Depok, West Java, Indonesia; Putera, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Khalisha, D.F., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Septiana, I., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia; Sitompul, R., Department of Ophthalmology, Faculty of Medicine, University of Indonesia – Cipto Mangunkusumo Kirana Eye HospitalJakarta, Indonesia |
Background: Polymerase chain reaction (PCR) is currently considered the method of choice for diagnosing ocular tuberculosis. However, the sensitivity and specificity of PCR using ocular samples remain uncertain. Our meta-analysis aimed to review the diagnostic accuracy of PCR testing in confirming ocular tuberculosis, with responses to antitubercular therapy (ATT) as reference indices. Methods: A systematic literature search of the PubMed, EBSCOHost, Scopus, and Google Scholar databases was performed using the standardized PRISMA guideline. Observational studies reporting both PCR MTb positivity and ATT response were included. Meta-analysis was performed to estimate the pooled positivity rate, sensitivity, specificity, positive and negative likelihood ratios, diagnostic odds ratios (DOR), and summary receiver operating curves (SROC). Results: The pooled positivity rate for PCR MTb was 0.55 (95% CI 0.44–0.67). The overall sensitivity and specificity were 88% (95% CI 83–92) and 71% (95% CI 60–80), respectively. The pooled DOR was 12.15 (95% CI 5.55–26.62). The area under the SROC was 0.83. Conclusions: The diagnostic accuracy of PCR Mtb is not sufficient for use as a benchmark for ocular TB diagnosis routinely based on ATT response. A negative result may help avoid prescribing unnecessary ATT in dilemmatic cases. © 2021 The Author(s) |
Diagnostic accuracy; Mycobacterium tuberculosis; polymerase chain reaction; uveitis |
ethambutol; ethambutol plus isoniazid plus pyrazinamide plus rifampicin; isoniazid; isoniazid plus rifampicin; pyrazinamide; rifampicin; steroid; tuberculostatic agent; tuberculostatic agent; antibiotic therapy; Article; controlled study; diagnostic accuracy; diagnostic test accuracy study; diagnostic value; false negative result; false positive result; human; inflammation; meta analysis; nonhuman; ocular tuberculosis; polymerase chain reaction; quantitative analysis; receiver operating characteristic; recurrent disease; regression analysis; sensitivity and specificity; serpiginous choroiditis; steroid therapy; systematic review; treatment duration; treatment response; genetics; Mycobacterium tuberculosis; polymerase chain reaction; tuberculosis; Antitubercular Agents; Humans; Mycobacteriu |
Elsevier B.V. |
12019712 |
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34364996 |
Article |
Q1 |
1278 |
2980 |
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214 |
Mecheva M.D.V., Rieger M., Sparrow R., Prafiantini E., Agustina R. |
57226430480;57205307158;57205017055;57193088368;57214141404; |
Snacks, nudges and asymmetric peer influence: Evidence from food choice experiments with children in Indonesia |
2021 |
Journal of Health Economics |
79 |
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102508 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111538660&doi=10.1016%2fj.jhealeco.2021.102508&partnerID=40&md5=652b5bd03857b33eba09516d04a40e6d |
The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands; Development Economics Group, Wageningen University, Netherlands; Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General HospitalJakarta, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Mecheva, M.D.V., The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands; Rieger, M., The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands; Sparrow, R., The International Institute of Social Studies (ISS) of Erasmus University Rotterdam, Netherlands, Development Economics Group, Wageningen University, Netherlands; Prafiantini, E., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General HospitalJakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia – Dr Cipto Mangunkusumo General HospitalJakarta, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Many children in low- and middle-income countries are growing up during a rapid nutrition transition. Experimental evidence on food choice in developing countries is scarce, while it is unclear to what extent evidence from high-income countries can be generalized. Children participated in a snack choice experiment. We expose some children to emoji labels encouraging healthy snacks, while others observe healthy or unhealthy snacking by peers. While emoji labels moderately promote healthy snacking, the adverse effect of observing a peer eating the unhealthy snack is very large. The effect associated with observing a healthy peer is insignificant. Additionally, cross-randomized blocks of children watched a nutrition video to study the interaction of information provision and nudging. The video independently improves healthy choices but does not aid the emoji nudge and cannot counter the strong negative peer effect. We compare our findings to studies conducted in developed countries and discuss policy implications. © 2021 The Author(s) |
Food choice; Indonesia; Nudges; Overweight; Peer effects |
body mass; child health; food policy; food preference; health expenditure; obesity; public health; adolescent; Article; child; child nutrition; controlled study; decision making; descriptive research; encouragement; fast food; female; human; human experiment; Indonesia; male; nutrition policy; obesity; peer pressure; pilot study; unhealthy diet; feeding behavior; food preference; nutritional status; Indonesia; Child; Feeding Behavior; Food Preferences; Humans; Indonesia; Nutritional Status; Peer Influence; Snacks |
Elsevier B.V. |
01676296 |
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34333202 |
Article |
Q1 |
2676 |
794 |
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218 |
Fachniadin A., Widi Nugroho S., Ananda Aman R., Ichwan S., Tandian D., Susanto E., Watanabe K., Nonaka Y. |
57222123314;57219659664;57222125502;57192906639;57192891173;57204423225;55704851200;36344004800; |
A Dumbbell-shaped hypoglossal schwannoma managed by a combination of open surgery and endoscopic assistance |
2021 |
Interdisciplinary Neurosurgery: Advanced Techniques and Case Management |
25 |
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101102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101531664&doi=10.1016%2fj.inat.2021.101102&partnerID=40&md5=aa132c91fdc36c35a156948ab70bdf91 |
Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Neurosurgery, Tokyo Jikei University School of Medicine, Tokyo, Japan; Department of Neurosurgery, Tokai University School of Medicine, Tokyo, Japan |
Fachniadin, A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Widi Nugroho, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ananda Aman, R., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ichwan, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Tandian, D., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Susanto, E., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Watanabe, K., Department of Neurosurgery, Tokyo Jikei University School of Medicine, Tokyo, Japan; Nonaka, Y., Department of Neurosurgery, Tokai University School of Medicine, Tokyo, Japan |
Background: Hypoglossal schwannoma is a rare benign tumor that comprises about 5% of all intracranial schwannoma. Surgical management for hypoglossal schwannoma is still evolving along with our understanding of neuroanatomy and surgical equipment improvement, especially endoscopy. The far lateral transcondylar approach is commonly used for hypoglossal schwannomas. This traditional approach requires great effort and is considered a lengthy procedure. The use of endoscopy gives an additional advantage to microscopic surgery in managing this tumor, making surgery less complicated and faster. Combining the microscope and endoscope is an effective way to operate in small corridors. Case: In a stepwise fashion, we present a case of a 53-year-old female with hypoglossal schwannoma, which was successfully resected using a retrosigmoid transcondylar approach with endoscopic assistance. Conclusion: A retrosigmoid transcondylar approach with endoscopic assistance is an excellent option in surgical management for hypoglossal schwannoma. Both microscopic and endoscopic approaches will be gaining more usefulness in managing skull base tumors and should be used collaboratively. © 2021 The Authors |
Dumbbell-shaped; Endoscopic; Hypoglossal schwannoma; Retrosigmoid transcondylar |
corticosteroid; fibrin glue; accessory nerve; adult; Article; brain stem; breathing exercise; cancer surgery; case report; cerebral revascularization; chemodectoma; chondroma; clinical article; clinical examination; cranial nerve; craniotomy; differential diagnosis; Doppler flowmetry; drinking; dysphagia; eating; female; histopathology; hoarseness; hospital discharge; human; hypoglossal nerve; intraoperative monitoring; intraoperative neurophysiological monitoring; jugular foramen; liquorrhea; mastoid; medulla oblongata; meningioma; middle aged; mitosis rate; muscle atrophy; neurilemoma; neuroanatomy; neuroendoscopy; neuroimaging; neuromonitoring; neurorehabilitation; nuclear magnetic resonance imaging; open surgery; paraganglioma; paralysis; parapharyngeal space; periosteum; physical exam |
Elsevier B.V. |
22147519 |
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Article |
Q4 |
202 |
19207 |
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225 |
Tandaju J.R., Ii W., Barati-Boldaji R., Raeisi-Dehkordi H. |
57222662533;57226738113;57204935735;57195065694; |
Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19): Reconsideration is needed |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
9 |
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2737 |
2739 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112531675&doi=10.1016%2fj.numecd.2021.06.009&partnerID=40&md5=51cf1abe5238935b3bcbca2d4b7a9969 |
Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Ii, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Barati-Boldaji, R., Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Raeisi-Dehkordi, H., Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
[No abstract available] |
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hydroxymethylglutaryl coenzyme A reductase inhibitor; human; COVID-19; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; SARS-CoV-2 |
Elsevier B.V. |
09394753 |
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34366177 |
Letter |
Q1 |
1127 |
3665 |
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262 |
Uchihara Y., Permata T.B.M., Sato H., Shibata A. |
57221723636;57197808751;55697961900;8323572900; |
Modulation of immune responses by DNA damage signaling |
2021 |
DNA Repair |
104 |
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103135 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106368761&doi=10.1016%2fj.dnarep.2021.103135&partnerID=40&md5=6d7c9e9634795d347738b7c970442465 |
Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Department of Radiation Oncology, Gunma University, Gunma, Japan |
Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, 10430, Indonesia; Sato, H., Department of Radiation Oncology, Gunma University, Gunma, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), Gunma UniversityGunma, Japan |
An accumulation of evidence indicates the importance of DNA damage signaling in modulating immune responses. Indeed, understanding the mechanism that underlies signal transduction originating from DNA damage is vital to overcoming refractory cancer, particularly when cancer immune therapy is applied in combination with DNA damage-dependent radio/chemotherapy. In addition, immune-associated responses to such signals can aggravate the symptoms of infections, allergies, autoimmune disease, and aging. In this review, we discuss how cells transduce signals, triggered by DNA damage, from their origins to neighboring cells and how this affects immune and inflammatory responses. © 2021 Elsevier B.V. |
Cancer therapy; DNA damage signaling; Immune crosstalk; Immune-associated disease; Inflammation |
nucleic acid; DNA; Article; cancer immunotherapy; DNA damage response; down regulation; human; immune response; immunomodulation; immunopathology; immunoregulation; inflammation; priority journal; signal transduction; animal; DNA damage; DNA repair; immunity; immunology; metabolism; neoplasm; signal transduction; Animals; DNA Damage; DNA Repair; DNA, Neoplasm; Humans; Immunity; Inflammation; Neoplasms; Signal Transduction |
Elsevier B.V. |
15687864 |
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34029876 |
Article |
Q1 |
2359 |
1004 |
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277 |
Sigit F.S., Trompet S., Tahapary D.L., Sartono E., Willems van Dijk K., Yazdanbakhsh M., Supali T., Smit J.W.A., Rosendaal F.R., de Mutsert R. |
57213595986;22954837300;55944492500;6701506022;57202571815;7006269286;6602742029;24577861400;7004174530;16042051400; |
The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
8 |
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2426 |
2435 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108275064&doi=10.1016%2fj.numecd.2021.05.012&partnerID=40&md5=b98f561673afb80c486c693b20480984 |
Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Sigit, F.S., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Trompet, S., Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Tahapary, D.L., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Sartono, E., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Willems van Dijk, K., Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Yazdanbakhsh, M., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Supali, T., Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Smit, J.W.A., Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Rosendaal, F.R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; de Mutsert, R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands |
Background and aims: At the same BMI, Asian populations develop cardiometabolic complications earlier than Western populations. We hypothesized that a different secretion of the adipocyte-derived hormones leptin and adiponectin plays a role and investigated the associations of the two hormones with the metabolic syndrome (MetS) in an Indonesian and a Dutch population. Methods and results: We performed cross-sectional analyses of the Netherlands Epidemiology of Obesity Study (n = 6602) and the SUGAR Scientific Programme Indonesia–Netherlands Study (n = 1461). We examined sex-stratified associations of leptin and adiponectin with MetS, using multivariate logistic regression including adjustment for total body fat. The mean (SD) leptin (mcg/L) were 4.7 (6.0) in Indonesian men, 18.6 (12.0) in Indonesian women, 9.1 (7.7) in Dutch men, and 23.4 (17.4) in Dutch women. The mean (SD) adiponectin (mg/L) were 5.7 (5.4), 7.5 (7.1), 6.6 (3.3), and 11.3 (4.9), respectively. Within the same BMI category, leptin concentrations were similar in the two populations, whereas adiponectin was lower in the Indonesian population. Per SD of leptin, adjusted prevalence odds ratios (ORs, 95%CI) of MetS were 0.9 (0.6–1.2) in Indonesian men, 1.1 (0.9–1.4) in Indonesian women, 2.2 (1.6–2.8) in Dutch men, and 1.2 (1.0–1.5) in Dutch women. Per SD of adiponectin, the ORs were 0.9 (0.7–1.2), 0.8 (0.7–1.0), 0.6 (0.6–0.8), and 0.4 (0.4–0.5), respectively. Conclusions: Despite lower adiponectin levels, adiponectin was not related to the MetS in the Indonesian population and can not explain their increased cardiometabolic risk at the same BMI. © 2021 The Author(s) |
Adiponectin; Asian; Leptin; The metabolic syndrome (MetS); Total body fat; Western |
adiponectin; ADIPOQ protein, human; biological marker; LEP protein, human; leptin; adolescent; adult; aged; blood; body mass; clinical trial; comparative study; cross-sectional study; female; human; Indonesia; male; metabolic syndrome X; middle aged; multicenter study; Netherlands; obesity; prevalence; randomized controlled trial (topic); risk assessment; sex factor; very elderly; young adult; Adiponectin; Adiposity; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Body Mass Index; Cardiometabolic Risk Factors; Cross-Sectional Studies; Female; Humans; Indonesia; Leptin; Male; Metabolic Syndrome; Middle Aged; Netherlands; Prevalence; Randomized Controlled Trials as Topic; Risk Assessment; Sex Factors; Young Adult |
Elsevier B.V. |
09394753 |
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34154890 |
Article |
Q1 |
1127 |
3665 |
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323 |
Rizka A., Setiati S., Sadikin M., Mansur I.G. |
57203243658;14325991900;57205093115;6603222374; |
Immunomodulatory effect of in vitro calcitriol in fit and frail elderly |
2021 |
International Immunopharmacology |
96 |
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107737 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105325886&doi=10.1016%2fj.intimp.2021.107737&partnerID=40&md5=bd310cacaf61c4b89ad48ac61ee52389 |
Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia |
Rizka, A., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia, Metabolic Vascular and Aging Cluster, Indonesian Medical Education and Research Institute Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Setiati, S., Division of Geriatric Medicine, Department of Internal Medicine Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National Hospital, Jakarta 10430, Indonesia; Sadikin, M., Department of Biochemistry Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia; Mansur, I.G., Department of Biology Faculty of Medicine Universitas Indonesia, Jakarta 10430, Indonesia |
Introduction: Effect of calcitriol on PBMCs of healthy adults have been well studied but not much is known about its effect on the PBMCs of elderly patients with various degree of frailty syndrome and immune senescence. This study was aimed to assess the effect of in vitro calcitriol immunomodulatory effect on IL-6, IL-10 and IFN-γ in elderly patients who were fit, pre-frail and frail to see which group of patients might get the most benefit of calcitriol. Methods: This study was an experimental study on the PBMCs of 24 elderly people, of which 8 subjects each were in fit, pre-frail and frail categories based on the Cardiovascular Health Study criteria. IL-6, IL-10, and IFN-γ were examined by ELISA, before and after administration of lipopolysaccharide and 100 pg/mL calcitriol into PBMC cultures in vitro. Result: The mean serum vitamin D level was 26.2 (2.4) ng/ml. Vitamin D level is decreasing along with worsening of frailty status. After LPS induction, calcitriol did not reduce IL-6 and IFN-γ in all the groups. Calcitriol increased IL-10 in all groups, with the most observed change in the pre-frail group. Conclusion: In vitro administration of calcitriol showed anti-inflammatory potential by increasing IL-10 mainly in pre-frail subjects. © 2021 Elsevier B.V. |
Calcitriol; Elderly; Frail; In vitro |
calcitriol; gamma interferon; interleukin 10; interleukin 6; lipopolysaccharide; vitamin D; calcitriol; gamma interferon; IFNG protein, human; IL10 protein, human; IL6 protein, human; interleukin 10; interleukin 6; vitamin D; aged; Article; cell culture; clinical article; controlled study; enzyme linked immunosorbent assay; experimental study; female; frail elderly; frailty; human; human cell; immunomodulation; in vitro study; male; peripheral blood mononuclear cell; priority journal; protein blood level; vitamin blood level; age; blood; drug effect; frail elderly; immunology; immunomodulation; metabolism; mononuclear cell; pharmacology; physiology; Age Factors; Aged; Calcitriol; Calcium-Regulating Hormones and Agents; Female; Frail Elderly; Humans; Immunomodulation; In Vitro Techniques; I |
Elsevier B.V. |
15675769 |
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33965881 |
Article |
Q1 |
1152 |
3523 |
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373 |
Dewi R., Kaswandani N., Karyanti M.R., Setyanto D.B., Pudjiadi A.H., Hendarto A., Djer M.M., Prayitno A., Yuniar I., Indawati W., Prawira Y., Handryastuti S., Sjakti H.A., Hidayati E.L., Muktiarti D., Soebadi A., Puspaningtyas N.W., Muhaimin R., Rahmadhany A., Octavius G.S., Puspitasari H.A., Jasin M.R., Tartila T., Putri N.D. |
57190859324;57195941745;56290680800;57203009929;18435202300;57204142249;12771087900;57193342301;57222295046;57190171077;55455747000;18434003700;57195720458;57200542624;57189047743;56986580800;57223288515;57223307995;57223290366;57221016506;57214119502;57223292665;57223304533;57200573842; |
Mortality in children with positive SARS-CoV-2 polymerase chain reaction test: Lessons learned from a tertiary referral hospital in Indonesia |
2021 |
International Journal of Infectious Diseases |
107 |
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78 |
85 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105478543&doi=10.1016%2fj.ijid.2021.04.019&partnerID=40&md5=6ef75a9ece8a84ed984ec94cf9c3f923 |
Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Dewi, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kaswandani, N., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Karyanti, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyanto, D.B., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pudjiadi, A.H., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hendarto, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djer, M.M., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prayitno, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yuniar, I., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indawati, W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prawira, Y., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handryastuti, S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sjakti, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayati, E.L., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muktiarti, D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebadi, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspaningtyas, N.W., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Muhaimin, R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmadhany, A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Octavius, G.S., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Puspitasari, H.A., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jasin, M.R., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tartila, T., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.D., Department of Paediatrics, Dr. Cipto Mangunkusumo National Central Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The incidence of coronavirus disease 2019 (COVID-19) is still increasing rapidly, but little is known about the prevalence and characteristics of fatal cases in children in Indonesia. This study aimed to describe the characteristics of children with COVID-19 with fatal outcomes in a tertiary referral hospital in Indonesia. Methods: This cross-sectional study used data collected from the medical records of patients with COVID-19 admitted to Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia from March to October 2020. Results: During the study period, 490 patients were admitted and diagnosed with suspected and probable COVID-19. Of these patients, 50 (10.2%) were confirmed to have COVID-19, and 20 (40%) had a fatal outcome. The fatality rate was higher in patients aged ≥10 years, categorized with severe disease upon admission, PaO2/FiO2 ratio ≤300 mmHg and chronic underlying diseases. The most common clinical manifestations were generalized symptoms, while acute respiratory distress syndrome (8/20) and septic shock (7/20) were the two most common causes of death. Increased procalcitonin, D-dimer, lactate dehydrogenase and presepsin levels were found in all fatal cases. One patient met the criteria of multisystem inflammatory syndrome in children. Conclusion: Our work highlights the high mortality rate in paediatric patients with positive SARS-CoV-2 polymerase chain reaction test. These findings might be related to or co-incided with COVID-19 infection. Further studies are needed to improve understanding of the role of severe acute respiratory syndrome coronavirus-2 in elaborating the mechanisms leading to death in children with comorbidities. © 2021 The Author(s) |
Children; COVID-19; Indonesia; Outcome; SARS-CoV-2 |
antibiotic agent; biological marker; D dimer; dobutamine; dopamine; enoxaparin; epinephrine; hydrocortisone; immunoglobulin; lactate dehydrogenase; lopinavir; noradrenalin; presepsin; procalcitonin; ritonavir; steroid; unclassified drug; adolescent; adult; adult respiratory distress syndrome; age; Article; artificial ventilation; cause of death; child; childhood mortality; clinical feature; coronavirus disease 2019; cross-sectional study; disease severity; fatality; female; Horowitz index; hospital admission; human; Indonesia; infant; major clinical study; male; mortality rate; newborn; pediatric multisystem inflammatory syndrome; polymerase chain reaction; preschool child; real time polymerase chain reaction; school child; septic shock; tertiary care center; complication; mortality; Adole |
Elsevier B.V. |
12019712 |
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33857609 |
Article |
Q1 |
1278 |
2980 |
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