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Sun X., Li R., Cai Y., Al-Herz A., Lahiri M., Choudhury M.R., Hidayat R., Suryana B.P.P., Kaneko Y., Fujio K., Van Hung N., Pandya S., Pang L.K., Katchamart W., Sigdel K.R., Paudyal B., Narongroeknawin P., Chevaisrakul P., Sun F., Lu Y., Ho C., Yeap S.S., Li Z., on behalf of APLAR RA SIG group |
57211390694;57026629100;56599490900;6508020635;26039213500;55408508400;37067327300;15728721800;8409247100;55029631300;57226144210;7103287746;57226150004;26654177400;56123182100;9244632800;35099091000;57191876780;57201927847;57226146642;57226138308;6701698220;57202324922; |
Clinical remission of rheumatoid arthritis in a multicenter real-world study in Asia-Pacific region |
2021 |
The Lancet Regional Health - Western Pacific |
15 |
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100240 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112352039&doi=10.1016%2fj.lanwpc.2021.100240&partnerID=40&md5=ef847be2cdf076f3416d77f746dcd1cd |
Department of Rheumatology & Immunology, Peking University People's Hospital, 11 Xizhimen South St.Beijing 100044, China; Department of Rheumatology & Immunology, Peking University Shenzhen Hospital, Shenzhen, China; Rheumatology Unit, Department of Internal Medicine, Al-Amiri Hospital, Kuwait City, Kuwait; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Department of Rheumatology, Bangabandhu Sheikh Mujib Medical UniversityDhaka, Bangladesh; Department of Internal Medicine, Cipto Mangunkusumo National Hospital Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rheumatology Division, Internal Medicine Department, Brawijaya University - Saiful Anwar Hospital, Indonesia; Division of Rheumatology, Department of Internal Medicine, Keio University School of MedicineTokyo, Japan; Department of Allergy and Rheumatology, Graduate School of Medicine, The University of TokyoTokyo, Japan; Department of Rheumatology, Bach Mai Hospital, Giai Phong Road, Dong Da DistrictHanoi, Viet Nam; Vedanta institute of medical sciences and VS hospital, Ahmedabad, India; Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore; Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Department of Internal Medicine, Patan Academy of Health Sciences, Kathmandu, Nepal; Division of Rheumatology, Department of Medicine, Phramongkutklao Hospital and College of MedicineBangkok, Thailand; Division of Allergy, Immunology and Rheumatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityBangkok, Thailand; Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Haidian DistrictBeijing 100191, China; School of Mathematical Science, Nankai University, No. 94 Weijin Road, Nankai DistrictTianjin 300071, China; Division of Rheumatology, Dept of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong; Department of Medicine, Subang Jaya Medical Centre, Selangor, Malaysia |
Sun, X., Department of Rheumatology & Immunology, Peking University People's Hospital, 11 Xizhimen South St.Beijing 100044, China; Li, R., Department of Rheumatology & Immunology, Peking University People's Hospital, 11 Xizhimen South St.Beijing 100044, China; Cai, Y., Department of Rheumatology & Immunology, Peking University Shenzhen Hospital, Shenzhen, China; Al-Herz, A., Rheumatology Unit, Department of Internal Medicine, Al-Amiri Hospital, Kuwait City, Kuwait; Lahiri, M., Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Choudhury, M.R., Department of Rheumatology, Bangabandhu Sheikh Mujib Medical UniversityDhaka, Bangladesh; Hidayat, R., Department of Internal Medicine, Cipto Mangunkusumo National Hospital Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Suryana, B.P.P., Rheumatology Division, Internal Medicine Department, Brawijaya University - Saiful Anwar Hospital, Indonesia; Kaneko, Y., Division of Rheumatology, Department of Internal Medicine, Keio University School of MedicineTokyo, Japan; Fujio, K., Department of Allergy and Rheumatology, Graduate School of Medicine, The University of TokyoTokyo, Japan; Van Hung, N., Department of Rheumatology, Bach Mai Hospital, Giai Phong Road, Dong Da DistrictHanoi, Viet Nam; Pandya, S., Vedanta institute of medical sciences and VS hospital, Ahmedabad, India; Pang, L.K., Department of Rheumatology, Allergy and Immunology, Tan Tock Seng Hospital, Singapore; Katchamart, W., Division of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol UniversityBangkok, Thailand; Sigdel, K.R., Department of Internal Medicine, Patan Academy of Health Sciences, Kathmandu, Nepal; Paudyal, B., Department of Internal Medicine, Patan Academy of Health Sciences, Kathmandu, Nepal; Narongroeknawin, P., Division of Rheumatology, Department of Medicine, Phramongkutklao Hospital and College of MedicineBangkok, Thailand; Chevaisrakul, P., Division of Allergy, Immunology and Rheumatology, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol UniversityBangkok, Thailand; Sun, F., Department of Epidemiology and Biostatistics, School of Public Health, Peking University, 38 Xueyuan Road, Haidian DistrictBeijing 100191, China; Lu, Y., School of Mathematical Science, Nankai University, No. 94 Weijin Road, Nankai DistrictTianjin 300071, China; Ho, C., Division of Rheumatology, Dept of Medicine, The University of Hong Kong, Hong Kong SAR, Hong Kong; Yeap, S.S., Department of Medicine, Subang Jaya Medical Centre, Selangor, Malaysia; Li, Z., Department of Rheumatology & Immunology, Peking University People's Hospital, 11 Xizhimen South St.Beijing 100044, China; on behalf of APLAR RA SIG group |
Background: Clinical remission is an attainable goal for Rheumatoid Arthritis (RA). However, data on RA remission rates from multinational studies in the Asia-Pacific region are limited. We conducted a cross-sectional multicentric study to evaluate the clinical remission status and the related factors in RA patients in the Asia-Pacific region. Methods: RA patients receiving standard care were enrolled consecutively from 17 sites in 11 countries from APLAR RA SIG group. Data were collected on-site by rheumatologists with a standardized case-report form. Remission was analyzed by different definitions including disease activity score using 28 joints (DAS28) based on ESR and CRP, clinical disease activity index (CDAI), simplified disease activity index (SDAI), Boolean remission definition, and clinical deep remission (CliDR). Logistic regression was used to determine related factors of remission. Findings: A total of 2010 RA patients was included in the study, the overall remission rates were 62•3% (DAS28-CRP), 35•5% (DAS28-ESR), 30•8% (CDAI), 26•5% (SDAI), 24•7% (Boolean), and 17•1% (CliDR), respectively, and varied from countries to countries in the Asia-Pacific region. Biological and targeted synthetic disease-modifying antirheumatic drugs (b/tsDMARDs) prescription rate was low (17•9%). Compared to patients in non-remission, patients in remission had higher rates of b/tsDMARDs usage and lower rates of GC usage. The favorable related factors were male sex, younger age, fewer comorbidities, fewer extra-articular manifestations (EAM), and use of b/tsDMARDs, while treatment with GC was negatively related to remission. Interpretation: Remission rates were low and varied in the Asia-Pacific region. Treatment with b/tsDMARDs and less GC usage were related to higher remission rate. There is an unmet need for RA remission in the Asia-Pacific region. © 2021 |
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26666065 |
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Raharjanti N.W., Purwadianto A., Soemantri D., Bardosono S., Mahajudin M.S., Poerwandari E.K., Levania M.K., Silalahi H.M.T.S., Rumthi P.T.S., Manulang T.K.P., Ramadianto A.S., Wiguna T. |
57226872499;18635479200;36640659100;21933841000;57218600581;25628305200;57226868672;57368578800;57368162800;57367333500;57226862690;24367785700; |
Self-confidence in conducting forensic psychiatric evaluations among general psychiatrists in Indonesia |
2021 |
Heliyon |
7 |
9 |
e08045 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120891523&doi=10.1016%2fj.heliyon.2021.e08045&partnerID=40&md5=2915417d45113bc152dbacad697562ef |
Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Forensic Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nutrition Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Psychiatry, Airlangga University, Surabaya, East Java, Indonesia; Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia |
Raharjanti, N.W., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Purwadianto, A., Forensic Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soemantri, D., Department of Medical Education, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Nutrition Department, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mahajudin, M.S., Department of Psychiatry, Airlangga University, Surabaya, East Java, Indonesia; Poerwandari, E.K., Faculty of Psychology, Universitas Indonesia, Jakarta, Indonesia; Levania, M.K., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Silalahi, H.M.T.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rumthi, P.T.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Manulang, T.K.P., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Ramadianto, A.S., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wiguna, T., Department of Psychiatry, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Objective: Several general psychiatrists experience lack of confidence when they perform forensic psychiatric evaluations that may be due to limited or insufficient training. This study aimed to determine whether structured forensic psychiatry educational modules are associated with general psychiatrists’ self-confidence in conducting forensic psychiatric evaluations in Indonesia. Method: A cross-sectional study was conducted with 246 general psychiatrists. A questionnaire was developed exclusively for this study by a group of experts based on relevant references and it was distributed online. Sample questions included: “How often do you perform forensic psychiatric evaluations?”, “As a general psychiatrist, are you confident in conducting forensic psychiatric evaluations?”, and “Do you experience any difficulties when conducting forensic psychiatric evaluations?” Data were analyzed through SPSS 20 for Windows; a p-value <0.05 indicated statistical significance. Results: Compared to general psychiatrists who did not study structured forensic psychiatry educational modules during their residency training, those exposed to such modules reported confidence in conducting forensic psychiatric evaluations in the following cases: insanity defense in cases of violence, insanity defense, fitness to stand trial, malingering, capacity to consent to treatment, risk of recidivism, guardianship, and parenting capacity. Furthermore, those with higher self-confidence were less likely to experience difficulties in conducting forensic psychiatric evaluations. Conclusion: Structured forensic psychiatry educational modules during general psychiatry residency training played an important role in the development of psychiatrists’ self-confidence. © 2021 The Author(s). Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license |
Forensic psychiatry module; Indonesia; Psychiatric evaluation; Self-confidence |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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184 |
Octaviana F., Harisman J., Wiratman W., Budikayanti A. |
26029958700;57368215900;57191920526;57194713932; |
Altered mental status in moderate-severe traumatic brain injury in Indonesia: the clinical manifestation and EEG features of non-convulsive status epilepticus |
2021 |
Heliyon |
7 |
9 |
e08067 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120866388&doi=10.1016%2fj.heliyon.2021.e08067&partnerID=40&md5=87d284823bcddaa9acf0b35b27598f23 |
Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Octaviana, F., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Harisman, J., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia; Wiratman, W., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Budikayanti, A., Neurology Department, Faculty of Medicine, Universitas Indonesia, Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Introduction: Moderate-to-severe traumatic brain injury (msTBI) can cause non-convulsive status epilepticus (NCSE). Electroencephalography (EEG) is employed as a diagnostic tool due to the non-specificity of clinical symptoms. This study aimed to identify clinical and EEG features related to NCSE in patients with msTBI. Methods: This was a cross-sectional study. Suspected NCSE in msTBI was examined using EEG data collected in consecutive patients from January 2017 to December 2019 at Dr. Cipto Mangunkusumo Hospital, Jakarta. Diagnoses of NCSE were made based on clinical manifestations and EEG features using the modified Salzburg Consensus Criteria for NCSE (mSCNC). Results: Of the 39 msTBI patients, 19 were diagnosed with NCSE; only two fulfilled the definitive criteria, and the remaining were possible NCSE. Delirium and perceptual impairment were only found in NCSE, while psychomotor agitation was higher (12.8% vs. 5.1% in NCSE vs. non-NCSE). The most common EEG feature was rhythmic activity (>0.5 Hz) without fluctuation, which improved with anti-epileptic drug administration. The Glasgow Coma Scale (GCS) score at onset and at hospitalisation discharge was significantly lower in patients with NCSE. The lesions in NCSE mostly originated from the temporal lobe. Injury to the temporal lobe had a significant relationship with NCSE occurrence (p ¼ 0.036, odds ratio 11.45 [95% confidence interval 1.17–111.6]). In this study, delirium, perceptual impairment, and psychomotor agitation were confirmed as NCSE using The most common discharge originated from the injured temporal lobe, and this site was a significant factor NCSE in patients with msTBI. in msTBI cases with clinical manifestations of altered mental status, psychomotor An injured temporal lobe was a susceptible site for the development of NCSE © 2021,Heliyon.All Rights Reserved. |
Altered mental status; Moderate-severe TBI; mSCNC; Non-convulsive status epilepticus |
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Elsevier Ltd |
24058440 |
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455 |
10919 |
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185 |
Kartika R.W., Alwi I., Suyatna F.D., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Reksodiputro M.H., Bardosono S. |
57223447932;15055173800;56039633100;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;35090488800;21933841000; |
The Role Of Vegf, Pdgf And Il-6 On Diabetic Foot Ulcer After Platelet Rich Fibrin Þ Hyaluronic Therapy |
2021 |
Heliyon |
7 |
9 |
e07934 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120851420&doi=10.1016%2fj.heliyon.2021.e07934&partnerID=40&md5=0080e19d2c656e3452c7827d2fab24ba |
Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science, Faculty of Medicine, Universitas Indonesia, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thorcic Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Current standard management of diabetic foot ulcers (DFUs) consists of surgical debridement followed by soak NaCl 0.9% gauzes tight infection and glycaemic control. Nowadays the use of advanced plateletrich fibrin (A-PRF) has emerged as an adjunctive method for treating DFUs. This study was conducted to demonstrate the ability of combine A-PRF þ HA as a complementary therapy in DFUs healing related with angiogenesis,inflammation and granulation index process. Methods: This open label randomized controlled trial was conducted in Koja District Hospital and Gatot Soebroto Hospital Jakarta, Indonesia on July 2019–April 2020. DFUs patients with wound duration of three months, Wagner-2, with size of ulcer less than 40 cm2 were included in the study. The number of subjects was calculated based on the rule of thumb and allocated randomly into three groups, namely topical A-PRF þ HA, A-PRF an Sodium Chloride 0.9% as a control, for each of 10 subjects. A-PRF made by 10 mL venous blood, centrifuge 200 G in 10 min, meanwhile A-PRF þ HA though mix both them with vertex machine around 5 min. Biomarker such as VEGF, PDGF and IL-6 examined from DFU taken by cotton swab and analysis using ELISA. Granulation Index was measured using ImageJ. Biomarkers and granulation index were evaluated on day 0, 3, 7 and 14. Data were analysed using SPSS version 20 with Anova and Kruskal Wallis test to compare the angiogenesis and inflammation effect between the three groups. Result: In topical dressing A-PRF þ HA, there is an increase in delta VEGF on day-3 (43.1 pg/mg protein) and day-7 (275,8 pg/mg protein) compared to A-PRF on day-3 (1.8 pg/mg protein) and day-7 (104.7 pg/mg protein), also NaCl (control) on day-3 (-4.9 pg/mg protein) and day-7 (28.3 pg/mg protein). So that the delta VEGF of A-PRF þ HA group increase significantly compared with others on day-3 (p ¼ 0.003) and day-7 (p < 0.001). Meanwhile APRF þ AH group, there is also a decrease in delta IL-6 after therapy on day-3 (-10.9 pg/mg protein) and day-7 (-18.3 pg/mg protein) compared to A-PRF in delta IL-6 on day-3 (-3.7 pg/mg protein) and on day-7 (-7.8 pg/ mg protein). In NaCl (control) group there is a increase delta IL-6 on day-3 (4.3 pg/mg protein) and on day-7 (35.5 pg/mg protein). So that the delta IL-6 of A-PRF þ HA group decrease significantly compared with others only on day-7 (p ¼ 0.015). In PDGF le level analysis, A-PRF þ HA group increase significantly (p ¼ 0.012) only in day -7 compare with other group (5.5 pg/mg protein). Conclusion: The study shows the superior role of combined A-PRF þ HA in the treatment DFU though increase angiogenesis and decrease inflammation pathway. The advantage of using A-PRF þ HA is that it accelerates wound healing by increasing granulation tissue compared to A-PRF alone © 2021 Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/) |
Diabetic foot ulcer; Hyaluronic acid; Platelet-rich fibrin |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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186 |
Sauriasari R., Madani R.A., Rozaliyani A., Sudiana D. |
16246507200;57367966600;57203065912;21934788800; |
The effect of repeated education using live demonstrations and videos of how to use inhalation drugs on quality of life for COPD patients |
2021 |
Heliyon |
7 |
9 |
e07870 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120850425&doi=10.1016%2fj.heliyon.2021.e07870&partnerID=40&md5=9a57b37dd2d801600bfd6633e55ec700 |
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Madani, R.A., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java, Indonesia; Rozaliyani, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudiana, D., Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Depok, Indonesia |
Repeated education regarding the proper use of inhalers can reduce the error rate in inhaler-using patients and improve COPD patients’ quality of life. This study investigates the effect of repeated education on the quality of life of COPD patients during the pandemic of COVID-19 from February to June 2020. Repeated education is provided using direct demonstrations to patients through educational media in the form of short videos made by the researchers for each inhaler type. This is a pre-experimental study design which was carried out prospectively at Grha Permata Ibu Hospital, Depok. The quality of life of 22 subjects was examined using the COPD assessmenttest (CAT) questionnaire. Each patient was given a direct verbal demonstration of the appropriate use of the inhaler. One month later, each patient was provided further education using less than 2 min of video sent to them online via the WhatsApp application. Final quality-of-life examination and assessment of inhaler technique were carried out three months after the initial examination. Assessment of proper inhaler technique was carried out using a specific checklist regarding the use of inhaler translated by the researcher. Before and after delivery of repeated education, the mean CAT score showed a decrease of two points, i.e., 12.8 ± 1.3 and 10.8 ± 2.0, respectively. This indicated that quality of life of the patients had significant improvement. However, as many as 63.6% of patients still made mistakes in using inhaler even though they had been educated. For DPI-type inhalers, mistake mostly happened at step “breath out gently, away from inhaler”. For pMDI-type inhalers, mistake mostly happened at step “while holding breath, remove inhaler from mouth”. It can be concluded that repeated education regarding proper inhaler technique with direct demonstrations and further maintained by videos can improve the quality of life in COPD patients. © 2021 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/bync-nd/4.0/). |
CAT (COPD Assessment test); Demonstration video; Inhaler; Repeated education |
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Elsevier Ltd |
24058440 |
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Q1 |
455 |
10919 |
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207 |
Kartini D., Panigoro S.S., Ham M.F., Harahap A.S., Rasyid S.H., Marcevianto K.V. |
57215490523;56790104300;57257336600;57218511857;57224779056;57256764400; |
Thyroid hemiagenesis associated with Hurthle cell carcinoma: A case report |
2021 |
International Journal of Surgery Case Reports |
86 |
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106372 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114820796&doi=10.1016%2fj.ijscr.2021.106372&partnerID=40&md5=a842dbe995f6b1a20d9b986dad8aad97 |
Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Kartini, D., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Panigoro, S.S., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Ham, M.F., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Harahap, A.S., Department of Pathological Anatomy, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rasyid, S.H., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Marcevianto, K.V., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction and importance: Thyroid hemiagenesis (TH) is a rare congenital anomaly where one lobe fails to develop, especially more frequently occurs on the left lobe. The exact mechanisms for thyroid morphogenesis remain unclear. In this paper, we report a rare case of right lobe TH associated with Hurthle cell carcinoma. Case presentation: A 59 years old woman was admitted with a neck lump increasing in size in the last 20 years. There were no symptoms of hyperthyroidism and hypothyroidism. There was a palpable, painless 5 cm mass in the middle of the neck. Initial thyroid ultrasonography (USG) revealed an enlarged left lobe, with hypoechoic lesion with cystic component and calcification (TIRADS 4). However, the right lobe was non-visualized. Fine needle aspiration biopsy result tendency was a malignancy. Hence, isthmolobectomy was conducted. Pathology result was Hurthle cell carcinoma. On the ninth month, USG revealed fibrotic tissue in the right thyroid bed and bilateral lymphadenopathy. Due to discrepancy, the patient was planned for a neck exploration surgery and a right lobe incision. Intraoperatively, the right thyroid was absent. Intraoperative USG also confirmed no right thyroid lobe. Discussion: Thyroid hemiagenesis can be visualized by using USG due to its practicality and cost effectiveness reasons. Follow up evaluations consisted of systematic monitoring of thyroid morphology and hormonal functions should follow the diagnosis of TH. Neck exploration surgery might need to be performed to clarify any discrepancy and confirm the diagnosis. Conclusion: TH can be recognized through supporting examination; however, discrepancy may occur. © 2021 The Authors |
Hurthle cell carcinoma; Neck exploration surgery; Thyroid hemiagenesis |
euthyrax; levothyroxine sodium; thyroglobulin; adult; Article; calcification; cancer diagnosis; cancer size; cancer surgery; case report; clinical article; color Doppler flowmetry; echography; female; fine needle aspiration biopsy; frozen section; histopathology; human; human tissue; incision; isthmolobectomy; lobectomy; lymph node; lymphadenopathy; middle aged; neck; neck tumor; parathyroid gland; physical examination; recurrent laryngeal nerve; thyroglobulin blood level; thyroid carcinoma; thyroid dysgenesis; thyroid hemiagenesis; thyroid lobe; thyroid parafollicular cell; thyroid surgery; vascularization; vein ligation |
Elsevier Ltd |
22102612 |
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232 |
17549 |
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212 |
Librianto D., Aprilya D. |
57192894799;57193710642; |
Cantilever method for severe kyphotic deformity correction in spondylitis tuberculosis: A technical note and literature review |
2021 |
Annals of Medicine and Surgery |
69 |
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102764 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113387050&doi=10.1016%2fj.amsu.2021.102764&partnerID=40&md5=65a7cd7e9c389e8ea978726e602d9fe3 |
Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Librianto, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Fatmawati General Hospital, Jakarta, Indonesia; Aprilya, D., Department of Orthopedic and Traumatology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: The kyphotic deformity is more than just a cosmetic disfigurement. It is potentially life-threatening and disturbs the quality of life by causing cardiopulmonary dysfunction, spinal imbalance, and other associated problems. Corrective surgery is challenging but it is needed to bring the spinal balance back thus halting the progressiveness of the deformity. The cantilever technique is a gold standard to correct the sagittal plane deformity. Methods: This is a review article with some case illustrations from Author's experience. Objective: We aim to review the cantilever technique for kyphotic correction in spondylitis tuberculosis patients. Conclusion: The cantilever technique is the standard for sagittal plane deformity correction that can be applied for kyphotic deformity correction in spondylitis tuberculosis cases. Developing the safest techniques and instrumentation is crucial to achieving spinal balance with minimal risk of morbidities. © 2021 |
Cantilever method; Deformity correction; Kyphotic deformity; Spondylitis tuberculosis |
cosmetic; backache; biopsy; bone graft; cardiopulmonary insufficiency; comorbidity; decortication; deformity; follow up; gold standard; graft failure; human; kyphosis; laminectomy; morbidity; nerve injury; nuclear magnetic resonance imaging; osteotomy; pain; quality of life; Review; screw loosening; spinal cord decompression; spinal cord lesion; spine malformation; systematic review; tissue culture; tuberculous spondylitis; vascularization |
Elsevier Ltd |
20490801 |
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Review |
Q3 |
391 |
12334 |
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234 |
Nugroho S.W., Pradhana I., Gunawan K. |
57460519700;57373805000;57195935319; |
New adaptation of neurosurgical practice and residency programs during the Covid-19 pandemic and their effects on neurosurgery resident satisfaction and welfare at the National General Hospital, Jakarta, Indonesia |
2021 |
Heliyon |
7 |
8 |
e07757 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121271314&doi=10.1016%2fj.heliyon.2021.e07757&partnerID=40&md5=09cbd414f0eefb36b6d98b642efa84cf |
Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Nugroho, S.W., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Pradhana, I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Many institutions in numerous countries have made changes in their health care services during the COVID-19 pandemic. One change has been to reduce elective neurosurgery cases, which has impacted neurosurgery education. Published literature is lacking about the healthcare services, education, and residents’ well-being during adaptation to the pandemic, especially in national referral hospitals in developing countries. Methods: We conducted a cross-sectional study on current neurosurgical services during 2020. We evaluated 34 neurosurgery residents in Cipto Mangunkusumo National General Hospital using a self-made questionnaire to determine the effects of the COVID-19 pandemic on their surroundings, education process, and satisfaction with the currently adapted education program. We used the modified Maslach Burnout Inventory to assess burnout in the residents before and during the pandemic. Results: Neurosurgical residents spent more time studying neurosurgical theory (Mode 1–1.5h/day, p < 0.05) but spent less time learning neurosurgical skills (Mode 30 min–1 h/day, p < 0.05) compared to before the pandemic. The resident satisfaction mean score (scale 0–10) was 7.58 for live surgery and 8.53 for the microsurgical skills lab training program. On a scale of 1–10, the residents’ stress level increased after the pandemic but the change was not statistically significant (6.61 ± 1.87, p > 0.05). The Modified Maslach Burnout inventory score was 3.02 ± 3.74 during the pandemic, and increased from before the pandemic (2.41 ± 3.18), but the difference was not statistically significant. Conclusion: The COVID-19 pandemics have reduced the working hours and the clinical exposure of neurosurgical residents. Fortunately, this pandemic has led to a new opportunity to find many suitable learning methods which may decrease the risk of burnout. The psychological burden of residents is still worrisome, and planned management is necessary to sustain resident performance. © 2021 |
COVID-19; Education; Neurosurgery; Neurosurgical residency; Pandemic; Residency |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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249 |
Kamal A.F., Ramang D.S. |
56648996700;57195942455; |
A simple management of massive bone defect after en-bloc resection of osteofibrous dysplasia of tibial shaft: A case report |
2021 |
International Journal of Surgery Case Reports |
85 |
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106213 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111724269&doi=10.1016%2fj.ijscr.2021.106213&partnerID=40&md5=fd1f09e882e103495b845ed8ef9477e1 |
Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Ramang, D.S., Department of Orthopaedic and Traumatology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction: Osteofibrous dysplasia is a relatively rare disease, exclusively found in children, affecting the tibial diaphysis. Various management approaches are already available, but an internationally approved management guideline is not yet established. There is a major concern in the current management of wide excision technique as it frequently results in massive bone defect. Case presentation: Here we present a case of osteofibrous dysplasia on a 10-year-old girl in Cipto Mangunkusumo Hospital with chief complaint of mild persistent pain of her lower leg since two years before with slight bowing deformity. The radiograph and histopathological examination support the diagnosis of osteofibrous dysplasia. She was managed with en-bloc resection (wide excision) of the tumor, followed with reconstruction using biomaterials substitute; combination between demineralized bone matrix (BonegenerR) and bone substitute “hydroxyapatite and calcium sulphate” and internal fixation using plate and screw. Results: Clinical and radiological evaluation showed successful improvement and outcome. The patient showed progressive functional outcomes and achieved functional score of 100% LEFS at 3 years follow-up. The plate and screw was removed at 48 weeks after adequate callus formation andradiological union was achieved. Conclusion: Simple reconstruction using biomaterial bone substitute not only created new bone formation with good stability, but also enabled patient to have an improved quality of life. This method is recommended to overcome the massive bone defect after tumor resection in osteofibrous dysplasia patient. © 2021 The Author(s) |
Biomaterial; Massive bone defect; Osteofibrous dyplasia; Wide excision |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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250 |
Miraj F., Nugroho A., Dalitan I.M., Setyarani M. |
56471854400;57211502355;57226482440;55883575900; |
The efficacy of ilizarov method for management of long tibial bone and soft tissue defect |
2021 |
Annals of Medicine and Surgery |
68 |
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102645 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111624016&doi=10.1016%2fj.amsu.2021.102645&partnerID=40&md5=90add1d384d132f92b578c2bb65882ad |
Pediatrics Orthopaedics and Limb Reconstruction Division, Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Miraj, F., Pediatrics Orthopaedics and Limb Reconstruction Division, Department of Orthopaedics and Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Nugroho, A., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dalitan, I.M., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyarani, M., Resident of Orthopaedics and Traumatology Department, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia/ Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Patients with open fracture Gustillo-Anderson grade 3 had undergone several surgical procedures, but still ended up with expose long dead bone or infected. Illizarov method was used to address long bone and soft tissue defect after re-debridement with radical resection of long dead bone or infected segment. Methods: We included 14 patients (mean age: 30.86 ± 11.49) with non-union tibial fracture with long dead and infected bone segment who had undergone several debridement, bone grafting or spacer and soft tissue closure procedure due to open fracture of tibia grade 3. The subjects underwent re-debridement with radical resection of dead or infected bone segment followed by Illizarov method to perform bone transport procedure for bone defect filling and simultaneously restore severe soft tissue loss and bone lengthening procedure. Results: All subjects had achieved satisfactory results with mean docking period of bone transport 3.78 ± 0.54 months, union time at the docking side 7 (5.5–9) months. Soft tissue was covered and no recurrence of infection. Three subjects had Leg Length Discrepancy (LLD) of 1 cm, whereas the remaining had zero discrepancy. No significant pain was observed at final follow-up and 4 patients had ankle joint stiffness. Conclusion: The Illizarov method can effectively address long bone and soft tissue defects by distraction osteogenesis through bone transport procedure that filling the defect gradually without bone graft and simultaneously enhancing soft tissue closure without tertiary soft tissue procedure subsequently followed with bone lengthening procedure to correct the limb length discrepancy. © 2021 |
Illizarov method; Long tibial bone defect; Non-union fracture of tibia; Soft tissue defect |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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