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422 |
Putra M.D., Rahyussalim A.J., Jusman S.W.A., Iswanti F.C., Sadikin M. |
57221617403;55212166100;36518792100;57192920851;36981411100; |
Phagocytosis and the antigen-processing abilities of macrophages derived from monocytes in spinal tuberculosis patients |
2021 |
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
23 |
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100215 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099630069&doi=10.1016%2fj.jctube.2021.100215&partnerID=40&md5=2548fbe746aaf9e6e815fb1375351254 |
Master's Program in Biomedical Science, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia10430, Indonesia; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta15419, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Indonesia |
Putra, M.D., Master's Program in Biomedical Science, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta15419, Indonesia; Rahyussalim, A.J., Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital10430, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia; Iswanti, F.C., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia |
This study examined the hypothesis that there is an impairment of macrophageal function in spinal TB. We examined macrophageal functions in spinal TB patients. Monocytes were isolated from peripheral blood mononuclear cells (PBMCs) of five spinal TB patients and five healthy persons as control. The isolated monocytes were cultured with stimulation of macrophage colony-stimulating factor (M-CSF) for seven days for maturation. The phagocytic ability of the macrophages derived from monocytes was measured. Also, nitric oxide (NO), myeloperoxidase (MPO), beta-glucuronide, and acid phosphatase activity was investigated. We found that the monocytes collected from patient PBMCs were significantly fewer than those of the control group (2992.103 vs. 6474.103 (cells/mL)). There were also fewer macrophages that had adhered to sheep red blood cells (SRBC) (598.103 vs. 264.103 (cells/mL)). However, NO production (2346 vs. 325.17 (µmol/gram of protein)), and the MPO (570.7 vs. 17.4 (unit/mg), beta-glucuronide (0.149 vs. 0.123 (μmol/hour/100 mg of protein)), and acid phosphatase activities (1776.9 vs. 287.9 (μmol/hour/100 mg of protein)) of the macrophages in the spinal TB group were markedly higher than in the healthy group. Despite the low adhesion to foreign bodies, the intracellular processing of TB macrophages, including oxidative activity and lysosome function, was significantly high. These results suggested the impairment of macrophageal function in spinal TB. Possibly, there is a dominance of innate non-specific immunity in spinal TB infection. © 2021 The Author(s) |
Acid phosphatase; Beta-glucuronidase; Macrophage; Myeloperoxidase; Nitric oxide; Spinal tuberculosis |
acid phosphatase; beta glucuronidase; colony stimulating factor 1; glucuronide; myeloperoxidase; nitric oxide; adult; antigen presentation; Article; cell adhesion; cell maturation; clinical article; controlled study; enzyme activity; female; foreign body; human; human cell; lysosome; macrophage; macrophage culture; macrophage function; male; monocyte; oxidation; phagocytosis; priority journal; sheep erythrocyte; tuberculous spondylitis |
Elsevier Ltd |
24055794 |
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Article |
Q3 |
585 |
8643 |
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461 |
Prasetyo M., Adistana I.M., Setiawan S.I. |
57192905252;57223019188;57195939543; |
Tuberculous septic arthritis of the hip with large abscess formation mimicking soft tissue tumors: A case report |
2021 |
Heliyon |
7 |
4 |
e06815 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104438407&doi=10.1016%2fj.heliyon.2021.e06815&partnerID=40&md5=e543449bd0c6c3d5e0c816cffc92a0e4 |
Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Prasetyo, M., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Adistana, I.M., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia; Setiawan, S.I., Department of Radiology, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo National Central General Hospital, Jakarta, Indonesia |
Background: Tuberculous septic arthritis is an infection that occurs inside the joint or synovial fluid and joint tissues caused by Mycobacterium tuberculosis. It may show wide variability of clinical symptoms and imaging appearance, ranging from asymptomatic with a normal radiographic examination to severe joint pain along with joint destruction, osteomyelitis, and abscess formation. This article presents radiographic and MR imaging appearance from a case of tuberculous septic arthritis with large abscess formation mimicking soft tissue tumor. Case presentation: We reported a 32-year-old female with a slowly enlarging lump on her right proximal thigh within the last 4 months along with slowly progressing joint pain. Both radiographic and MR images showed destruction of the femoral head and acetabular roof, with a formation of large rim-enhanced abscess that extending superficially and distally until mid-thigh. The patient underwent open drainage surgery and excisional biopsy. Histopathological examination showed chronic granulomatous inflammation caused by tuberculous infection. Conclusion: MR imaging combined with radiographic and clinical information played a very important role in the diagnosis of tuberculous septic arthritis with abscess, and to differentiate it from soft tissue neoplasms. © 2021 The Author(s) |
Abscess; Infectious arthritis; Septic arthritis; Tuberculosis |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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469 |
Surendra H., Elyazar I.R., Djaafara B.A., Ekawati L.L., Saraswati K., Adrian V., Widyastuti, Oktavia D., Salama N., Lina R.N., Andrianto A., Lestari K.D., Burhan E., Shankar A.H., Thwaites G., Baird J.K., Hamers R.L. |
57192694199;6506894785;57211600737;55600338600;57201491297;57221369753;57221446622;57219415909;57219411020;57221371068;57221369803;57221368778;36058554600;7005442634;6603796838;15921267800;23034345900; |
Clinical characteristics and mortality associated with COVID-19 in Jakarta, Indonesia: A hospital-based retrospective cohort study |
2021 |
The Lancet Regional Health - Western Pacific |
9 |
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100108 |
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11 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103798622&doi=10.1016%2fj.lanwpc.2021.100108&partnerID=40&md5=5627a271c3a8af3583dd02d7d63fadab |
Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Centre for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Akademi Ilmuwan Muda Indonesia, Jakarta, Indonesia; MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Jakarta Provincial Health Office, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam |
Surendra, H., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia, Akademi Ilmuwan Muda Indonesia, Jakarta, Indonesia; Elyazar, I.R., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Akademi Ilmuwan Muda Indonesia, Jakarta, Indonesia; Djaafara, B.A., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London, United Kingdom; Ekawati, L.L., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Saraswati, K., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Adrian, V., Jakarta Provincial Health Office, Jakarta, Indonesia; Widyastuti, Jakarta Provincial Health Office, Jakarta, Indonesia; Oktavia, D., Jakarta Provincial Health Office, Jakarta, Indonesia; Salama, N., Jakarta Provincial Health Office, Jakarta, Indonesia; Lina, R.N., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Andrianto, A., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Lestari, K.D., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia; Burhan, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Shankar, A.H., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Thwaites, G., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Oxford University Clinical Research Unit, Hospital for Tropical Diseases, Ho Chi Minh City, Viet Nam; Baird, J.K., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Hamers, R.L., Eijkman-Oxford Clinical Research Unit, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Data on COVID-19-related mortality and associated factors from low-resource settings are scarce. This study examined clinical characteristics and factors associated with in-hospital mortality of COVID-19 patients in Jakarta, Indonesia, from March 2 to July 31, 2020. Methods: This retrospective cohort included all hospitalised patients with PCR-confirmed COVID-19 in 55 hospitals. We extracted demographic and clinical data, including hospital outcomes (discharge or death). We used logistic regression to examine factors associated with mortality. Findings: Of 4265 patients with a definitive outcome by July 31, 3768 (88%) were discharged and 497 (12%) died. The median age was 46 years (IQR 32–57), 5% were children, and 31% had >1 comorbidity. Age-specific mortalities were 11% (7/61) for <5 years; 4% (1/23) for 5–9; 2% (3/133) for 10–19; 2% (8/638) for 20–29; 3% (26/755) for 30–39; 7% (61/819) for 40–49; 17% (155/941) for 50–59; 22% (132/611) for 60–69; and 34% (96/284) for ≥70. Risk of death was associated with higher age, male sex; pre-existing hypertension, diabetes, or chronic kidney disease; clinical diagnosis of pneumonia; multiple (>3) symptoms; immediate ICU admission, or intubation. Across all ages, risk of death was higher for patients with >1 comorbidity compared to those without; notably the risk was six-fold increased among patients <50 years (adjusted odds ratio 5.87, 95%CI 3.28–10.52; 27% vs 3% mortality). Interpretation: Overall in-hospital mortality was lower than reported in high-income countries, probably due to younger age distribution and fewer comorbidities. Deaths occurred across all ages, with >10% mortality among children <5 years and adults >50 years. © 2021 |
children; coronavirus; COVID-19; Indonesia; Mortality; SARS-CoV-2 |
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Elsevier Ltd |
26666065 |
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Article |
#N/A |
#N/A |
#N/A |
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470 |
Takhwifa F., Aninditha T., Setiawan H., Sauriasari R. |
57222711645;57189611205;55292870100;16246507200; |
The potential of metformin as an antineoplastic in brain tumors: A systematic review |
2021 |
Heliyon |
7 |
4 |
e06558 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103788211&doi=10.1016%2fj.heliyon.2021.e06558&partnerID=40&md5=ec9287d374f7d13b7c0752898249a4ba |
Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Takhwifa, F., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Aninditha, T., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiawan, H., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia; Sauriasari, R., Faculty of Pharmacy, Universitas Indonesia, Depok, West Java 16424, Indonesia |
Brain tumors are challenging to handle and cause severe mortality and morbidity. The primary therapy for brain tumors, a combination of radiotherapy, chemotherapy (i.e temozolomide), and corticosteroids, is considered inadequate to improve patients' clinical conditions and associated with many adverse effects. There is an urgent need for new compounds or repurposing of existing therapies, which could improve brain tumor patients' prognosis. Metformin, commonly used for type 2 diabetes medication, has been examined for its protective action in cancer, reducing cancer risk and cancer-related mortality. However, its effect on cancer is still in rigorous debate. This study examines recent studies on the effects of metformin in primary brain tumor patients through systematic reviews. The literature search was performed on PubMed, ScienceDirect, and SpringerLink databases for articles published between 2013 and 2020. We selected clinical studies comparing the therapeutic outcomes of brain tumor therapy with and without metformin. The clinical benefits of the drug were assessed through the overall survival (OS) and progression-free survival (PFS) of brain tumor patients. Those studies demonstrated that the combination of metformin with temozolomide given post-radiotherapy resulted in better OS and PFS. Nonetheless, the efficacy and safety of metformin need further clinical testing in the wider population. © 2021 The Authors |
Antidiabetic; Antineoplastic; Metformin; Primary brain tumor; Survival |
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Elsevier Ltd |
24058440 |
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Review |
Q1 |
455 |
10919 |
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471 |
Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H. |
57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049; |
The knowledge of Indonesian pediatric residents on hyperbilirubinemia management |
2021 |
Heliyon |
7 |
4 |
e06661 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103706107&doi=10.1016%2fj.heliyon.2021.e06661&partnerID=40&md5=fe30c346677666133417d4195cc4b825 |
Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Hyperbilirubinemia in the newborn occurs more frequently in Indonesia. Therefore, it is important that pediatric residents in Indonesia acquire adequate knowledge of hyperbilirubinemia management. This study aims to determine the pediatric residents' knowledge on hyperbilirubinemia management, whether they follow recommended guidelines, and whether differences exist between five large Indonesian teaching hospitals. We handed out a 25-question questionnaire on hyperbilirubinemia management to pediatric residents at five teaching hospitals. A total of 250 questionnaires were filled in completely, ranging from 14 to 113 respondents per hospital. Approximately 76% of the respondents used the Kramer score to recognize neonatal jaundice. Twenty-four percent correctly plotted the total serum bilirubin levels (TSB) on the phototherapy (PT) nomograms provided by the American Academy of Pediatrics (AAP) and the National Institute for Health and Care Excellence (NICE) for full-term and nearly full-term infants. Regarding preterm infants <35 weeks' gestational age, 66% of the respondents plotted TSB levels on the AAP nomogram, although this nomogram doesn't apply to this category of infants. Seventy percent of residents knew when to perform an exchange transfusion whereas 27% used a fixed bilirubin cut-off value of 20 mg/dL. Besides PT, 25% reported using additional pharmaceutical treatments, included albumin, phenobarbitone, ursodeoxycholic acid and immunoglobulins, while 47% of the respondents used sunlight therapy, as alternative treatment. The limited knowledge of the pediatric residents could be one factor for the higher incidence of severe hyperbilirubinemia and its sequelae. The limited knowledge of the residents raises doubts about the knowledge of the supervisors and the training of the residents since pediatric residents receive training from their supervisors. © 2021 The Author(s) |
Guidelines; Hyperbilirubinemia; Knowledge; Newborn infants; Residents |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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472 |
Kurniawan A., Wijaya T., Hutami W.D. |
57204398223;57222656233;57219938996; |
Spontaneous healing of a traumatic critical radius bone defect in adolescent: A rare case report |
2021 |
International Journal of Surgery Case Reports |
81 |
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105806 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103668624&doi=10.1016%2fj.ijscr.2021.105806&partnerID=40&md5=4c70b264f853582354fc36b39f9dc680 |
Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Kurniawan, A., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Wijaya, T., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Hutami, W.D., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Introduction and importance: Fracture with a critical bone loss is associated with a profound burden of disease impact. Although there are several options exist for its treatment, but still those reconstructive procedures are technically demanding, relatively expensive and sometimes the result is less than what was expected. The objective of this study is to report a rare case of spontaneous healing of a critical radial bone defect in an adolescent. Case presentation: We reported a 15 year old boy with a segmental open fracture of left radius, open fracture of left distal shaft ulna and closed fracture of left intercondylar humerus. The middle fragment of a fractured radius was extruded out, pulled out and then thrown away by his parent. Debridement, open reduction, and internal fixation for ulna were performed as well as reposition and internal fixation for the intercondylar humerus fracture. The plan was to wait until the ulnar fracture and intercondylar fracture to heal without any sign of infection and proceed to overcome the radial critical bone defect. This case report had been reported in line with SCARE criteria. The patient showed up seven months later with solid union of the critical radius bone defect and fully functioning hand with only slight limitation in pronation. Clinical discussion: Osteogenesis in fracture requires osteogenic cells, osteoinductive components, osteoconductive scaffold, and stability. Despite the fact that critical bone defect poses great challenge for its management, intact periosteum and sufficient soft tissue perfusion were able to provide those biologic requirements adequately for fracture healing and ensure spontaneous healing of a traumatic critical bone loss in adolescent without any reconstructive procedure. Conclusion: Spontaneous healing in critical bone defect is possible, provided all the favorable factors present to support this phenomenon. © 2021 The Authors |
Adolescent bone defect; Case report; Critical bone defect; Rare case; Spontaneous healing |
antibiotic agent; adolescent; arm swelling; Article; bone defect; case report; clinical article; debridement; distal humerus; distal radius; elbow; emergency care; falling; follow up; forearm; fracture healing; hand function; hospital admission; human; humerus fracture; male; medical history; metaphysis; open fracture; open fracture reduction; osteolysis; osteosynthesis; outcome assessment; outpatient department; periosteum; physical examination; priority journal; pronation; radial critical bone defect; radius fracture; radius shaft fracture; range of motion; reconstructive surgery; soft tissue; treatment planning; tree; ulna fracture; wound care; wound healing |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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473 |
Latief W., Enggra N. |
57210959510;57222656758; |
Spiral oblique retinacular ligament reconstruction using lateral band technique to treat swan neck deformity due to chronic mallet finger: A case report |
2021 |
International Journal of Surgery Case Reports |
81 |
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105811 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103658803&doi=10.1016%2fj.ijscr.2021.105811&partnerID=40&md5=ae6327366a0890dab1d668217845c18e |
Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Latief, W., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Enggra, N., Department of Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Swan neck deformity (SND) is characterized by hyperextension of proximal interphalangeal (PIP) joint and extension lag of distal interphalangeal (DIP) joint with functional loss of finger and impairs of tight grip of the finger. SND often results from chronic mallet injury and requires surgical treatment. One of the procedure is spiral oblique retinaculum ligament (SORL) reconstruction. We reported good outcome of swan neck deformity due to chronic mallet finger cases treated with SORL reconstruction using lateral band technique. Case presentation: We presented 2 case of swan neck deformity due to chronic mallet finger. A 21-year-old male with deformity of the left index finger for 2 years with with extension lag 50° and −20° PIP joint hyperextension and A 18-year-female with deformity of right ring finger for 4 years with extension lag 40° and −20° PIP joint hyperextension. We performed SORL reconstruction using lateral band technique. Ten weeks after surgery, patient achieved good range of motion and stability of PIP and DIP joint was obtained. Discussion: SORL reconstruction in a finger with a chronic mallet deformity coordinates extension of PIP and DIP joints by a dynamic tenodesis effect. This concept improves stability of both DIP and PIP joints by linking the volar flexor sheath to the lateral aspect of the terminal tendon using lateral band, thereby providing a mechanism of for automatic DIP joint extension upon active PIP extension. Conclusion: SORL reconstruction using lateral band technique may be a good choice for treating swan neck deformity. © 2021 |
Chronic mallet finger; Lateral band; SORL; Swan neck deformity |
adult; Article; case report; chronic mallet injury; clinical article; female; finger injury; finger malformation; follow up; high school student; human; index finger; interphalangeal joint; lateral band technique; ligament surgery; male; outcome assessment; passive movement; physical examination; priority journal; range of motion; right handedness; ring finger; spiral oblique retinacular ligament reconstruction; surgical technique; swan neck deformity; young adult |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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474 |
Yulian E.D., Pandelaki J., Kodrat E., Wibisana I.G.N.G. |
55983956600;35759266900;57191430080;57219660008; |
Forequarter amputation post transarterial chemoembolization and radiation in synovial sarcoma: A case report |
2021 |
International Journal of Surgery Case Reports |
81 |
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105824 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103395086&doi=10.1016%2fj.ijscr.2021.105824&partnerID=40&md5=5ca80e2a67c402ef91b604a618b712a1 |
Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Interventional Radiology Division, Department of Radiology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia |
Yulian, E.D., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Pandelaki, J., Interventional Radiology Division, Department of Radiology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Kodrat, E., Department of Anatomical Pathology, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia; Wibisana, I.G.N.G., Surgical Oncology Division, Department of Surgery, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Indonesia |
Introduction and importance: Forequarter amputation or interscapulathoracalis amputation is a major amputation procedure that involves the entire upper extremity, scapula, and a whole or part of the clavicula. Forequarter amputation is commonly used to control bleeding in malignant tumor cases in which no treatment is available for the extremities. Case presentation: We report a case of forequarter amputation in a 25-year-old patient with synovial sarcoma. Transarterial chemoembolization (TACE) and radiation synovial sarcoma were performed in the patient to reduce bleeding. This technique may also be used for treating synovial sarcoma with massive bleeding. Clinical discussion: Despite forequarter amputation indications in malignant tumor cases and recurrent cancer cases, the effectiveness of this technique remains unclear. The patient was readmitted with a recurrent mass three months after surgery. Conclusion: In this study, TACE and radiotherapy are effective in controlling bleeding preoperatively and intraoperatively in patients with synovial sarcoma. © 2021 The Authors |
Case report; Forequarter amputation; Radiation; Synovial sarcoma; Transarterial chemoembolization |
corticosteroid; doxorubicin; epithelial membrane antigen; gelfoam; iodinated poppyseed oil; polyvinyl alcohol; povidone iodine; protein S 100; sulfadiazine silver; adult; arm amputation; Article; axillary artery; bleeding; blood transfusion; cancer patient; cancer radiotherapy; cancer surgery; case report; cauterization; chemoembolization; chronic pain; clinical article; clinical feature; corticosteroid therapy; device removal; digital subtraction angiography; fibromyxosarcoma; forequarter amputation; histopathology; human; human tissue; immunohistochemistry; lymphedema; nuclear magnetic resonance imaging; pectoralis major muscle; postoperative hemorrhage; primary tumor; priority journal; right subclavian artery; shoulder girdle; spindle cell sarcoma; synovial sarcoma; tumor volume; young |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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475 |
Wardoyo S., Kamal A.F., Furqon M.A., Grantomo J., Hutami W.D. |
57211106608;56648996700;57199553328;57211348862;57219938996; |
Osteosarcoma of the rib: A challenge of diagnosis and surgical intervention: A case report |
2021 |
International Journal of Surgery Case Reports |
81 |
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105777 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103309878&doi=10.1016%2fj.ijscr.2021.105777&partnerID=40&md5=c0e9ffb86aab88f11e96ff07a17d967a |
Division of Cardiothoracic and Vascular Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Orthopedics and Traumatology, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Resident of Cardiothoracic and Vascular Surgery, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Resident of Orthopaedic and Traumatology, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Wardoyo, S., Division of Cardiothoracic and Vascular Surgery, Department of Surgery, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Kamal, A.F., Department of Orthopedics and Traumatology, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Furqon, M.A., Resident of Cardiothoracic and Vascular Surgery, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Grantomo, J., Resident of Cardiothoracic and Vascular Surgery, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hutami, W.D., Resident of Orthopaedic and Traumatology, Universitas Indonesia/Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Introduction and importance: Chest wall tumour could grow from various tissues composing the chest wall. Diagnosis and treatment of patients with chest wall tumour pose several challenges. Case presentation: We present a case of 55 year old woman with chief complaint of a painfull mass on her chest wall. Patient was diagnosed with osteosarcoma of the ribs. Patient underwent surgery and was hospitalized for seven days before discharged. Clinical discussion: Osteosarcoma of the ribs is a rare case with wide resection as the main treatment. In this case, chest wall reconstruction was needed to prevent impaired chest wall mechanical function in respiration. Conclusion: Diagnosis and treatment of osteosarcoma of the ribs pose challenges. The main treatment of the osteosarcoma of the ribs is wide resection, followed by reconstruction of chest wall when needed. Reconstruction could be performed with autologous tissue, gore-tex, and mesh. The adjuvant chemotherapy was considered to give for better outcome. © 2021 The Authors |
Chest wall reconstruction; Chest wall tumour; Osteosarcoma of the ribs |
antineoplastic agent; adjuvant chemotherapy; adult; Article; bone destruction; calcification; cancer surgery; case report; clinical article; contrast enhancement; female; histopathology; human; middle aged; osteosarcoma; priority journal; rib; thorax pain; thorax radiography; thorax wall reconstruction; thorax wall tumor; x-ray computed tomography |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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476 |
Kamal A.F., Abubakar I., Salamah T. |
56648996700;57204179162;57195380322; |
Alkaline phosphatase, lactic dehidrogenase, inflammatory variables and apparent diffusion coefficients from MRI for prediction of chemotherapy response in osteosarcoma. A cross sectional study |
2021 |
Annals of Medicine and Surgery |
64 |
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102228 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102644624&doi=10.1016%2fj.amsu.2021.102228&partnerID=40&md5=fd665964a20c5345b17f1145f1383619 |
Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Orthopaedic and Traumatology-Department of Surgery Faculty of Medicine Universitas Syiah Kuala/ Zainoel Abidin General Hospital, Banda Aceh, Indonesia; Department of Radiology Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo, General Hospital, Jakarta, Indonesia |
Kamal, A.F., Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Abubakar, I., Department of Orthopaedic and Traumatology Faculty of Medicine Universitas Indonesia/ Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Division of Orthopaedic and Traumatology-Department of Surgery Faculty of Medicine Universitas Syiah Kuala/ Zainoel Abidin General Hospital, Banda Aceh, Indonesia; Salamah, T., Department of Radiology Faculty of Medicine Universitas Indonesia/Cipto Mangunkusumo, General Hospital, Jakarta, Indonesia |
Background: This present study aimed to assess if clinical, laboratory and MRI were an accurate benchmark in assessing the effectiveness of neoadjuvant chemotherapy in osteosarcoma patients. Methods: This was an observational analytic study with a cross-sectional design. We correlated among clinical, laboratory and magnetic resonance imaging (MRI) data before and after neoadjuvant chemotherapy; and percentage of tumor necroses from osteosarcoma patients during the period between January 2017–July 2019. Results: Of the 58 patients included in this study, 38 were male and 20 were female aged 5 - 67 years (mean: 16-year-old. 37(63.8%) patients underwent neoadjuvant chemotherapy with CAI regimens and 13 (36.2%) with CA regiments. The tumors were classified as stage IIB in 43 (74.1%) patients and stage III in 15 (25.9%) patients. Wilcoxon test showed significant differences between alkaline phosphatase (ALP), erythrocyte sedimentation rate (ESR), and neutrophil to lymphocyte ratio (NLR) before and after neoadjuvant chemotherapy in the poor-response group. We found no significant difference between lactic dehydrogenase (LDH) and lymphocyte-to-monocyte ratio (LMR) before and after neoadjuvant chemotherapy in the good-response group. MRI revealed decreased tumor volume in patients in the good-response to chemotherapy. Conclusion: We demonstrated that ALP level was statistically significant in the poor-response group. We also found that LDH value before neoadjuvant chemotherapy had a strong correlation with degree of necrosis and could be used as a predictive indicator. MRI plays an important role in evaluating tumor volumes and preoperative radiological changes to predict histological necrosis. © 2021 |
Alkaline phospkatase; Chemotherapy; LDH; MRI Apparent diffusion coefficients; NLR,LMR; Osteosarcoma |
alanine aminotransferase; alkaline phosphatase; C reactive protein; cisplatin; doxorubicin; fluorodeoxyglucose f 18; ifosfamide; lactate dehydrogenase; adjuvant therapy; adolescent; adult; aged; analytical research; apparent diffusion coefficient; Article; cancer chemotherapy; cancer size; cancer staging; child; comparative effectiveness; computer assisted tomography; cross-sectional study; erythrocyte sedimentation rate; female; histology; human; human tissue; hypertransaminasemia; lymphocyte monocyte ratio; major clinical study; male; MSTS score; neoadjuvant chemotherapy; neutrophil lymphocyte ratio; nuclear magnetic resonance imaging; observational study; osteosarcoma; platelet lymphocyte ratio; receiver operating characteristic; retrospective study; scoring system; treatment response; |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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