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331 |
Irdam G.A., Febriyani, Rasyid N., Taher A. |
57194729795;57226319849;56245069300;7005269743; |
A systematic review of intracavernosal injection of mesenchymal stem cells for diabetic erectile dysfunction |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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96 |
105 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110674329&doi=10.13181%2fmji.oa.204475&partnerID=40&md5=41f468eff0f07099de19a39da32f2a41 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irdam, G.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Febriyani, Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND As current erectile dysfunction (ED) treatments are limited, other treatment such as stem cells should be explored. Hence, this study aimed to review the sources, method of administration, and therapeutic effect of mesenchymal stem cells (MSCs) for diabetic ED treatment. METHODS All relevant articles regarding the use of MSCs for diabetic ED were searched in PubMed and Google Scholar databases from December 15, 2019 to January 1, 2020 published in the past 10 years. The keywords were “mesenchymal stem cells” and “diabetic ED”. The selection and critical appraisal of the studies were discussed. Diabetic ED was evaluated for functional and structural outcome. Functional outcome in animal studies was assessed by intracavernosal pressure/mean arterial pressure (ICP/ MAP) ratio, meanwhile the structural outcome was done microscopically. In human study, the assessments were done using international index of erectile function score (IIEF-5) to erection hardness score and penile Doppler ultrasonography. RESULTS There were 10 animal studies and 3 human studies. The studies used MSCs from adipose (n = 6), bone marrow (n = 4), placenta (n = 1), umbilical cord (n = 1), and muscle tissue (n = 1). The MSCs were administrated through intracavernosal injection in all studies. In all animal studies, functional outcome was improved, shown in higher ICP/MAP ratio. Microscopically, there were an increase of cavernosal endothelial cells, vascular endothelial growth factor, nitric oxide synthase, and smooth muscle cells. In human studies, IIEF-5 and erection hardness score were improved. Peak systolic velocity was also higher. CONCLUSIONS MSCs may be a promising therapy for diabetic ED; however, long-term safety concerns still need further investigations. © 2021, Faculty of Medicine, Universitas Indonesia. All rights reserved. |
Diabetes mellitus; Erectile dysfunction; Mesenchymal stem cells |
arterial pressure; Article; body mass; bone marrow; data extraction; DNA damage; Doppler ultrasonography; echography; erectile dysfunction; genomic instability; hardness; histochemistry; human; insulin sensitivity; International Index of Erectile Function; intracavernous pressure; mesenchymal stem cell; nonhuman; peak systolic velocity; placenta; questionnaire; shock wave therapy; smooth muscle cell; systematic review; umbilical cord |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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345 |
Parikesit D., Witjaksono F., Mochtar C.A., Rasyid N., Hamid A.R.A.H. |
57163830300;57070455800;6506558321;56245069300;57202054669; |
Impact of metabolic syndrome on lower urinary tract symptoms in patients with benign prostate hyperplasia |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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138 |
142 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110781511&doi=10.13181%2fmji.oa.214256&partnerID=40&md5=1ca9a518c25b6145dc4dc6f550d2833e |
Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, West Java, Depok, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Parikesit, D., Urology Medical Staff Group, Universitas Indonesia Hospital, Universitas Indonesia, West Java, Depok, Indonesia; Witjaksono, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mochtar, C.A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamid, A.R.A.H., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND Studies evaluating the relationship between metabolic syndrome (MetS) and lower urinary tract symptoms (LUTS) in men with benign prostate hyperplasia (BPH) are lacking in Indonesia. This study aimed to discover the association of LUTS and MetS in men with BPH. METHODS Subjects who underwent biopsy were recruited from Cipto Mangunkusumo Hospital, Jakarta, Indonesia from January 2014 to January 2018, but only men who had biopsy-proven BPH were included. Body mass index, waist circumference, fasting blood glucose, triglyceride, high-density lipoprotein, prostate volume (PV), and international prostate symptom score (IPSS) were collected before the biopsy. MetS criteria were based on the National Cholesterol Education Program Adult Treatment Panel III. IPSS was assessed for LUTS and consisted of irritative and obstructive symptoms and quality of life (QoL). Independent t-test or Mann–Whitney test was used to analyze numerical data. RESULTS Of 227 men with biopsy-proven BPH, 87 (38.3%) were diagnosed with MetS. PV was similar in men with or without MetS (54.4 [20.3–100] versus 49.9 [19.5–100] cm3, p = 0.239). Men with MetS generally had more LUTS (15 [1–30] versus 11 [0–35], p = 0.005), more irritative symptoms (8 [0–20] versus 6 [0–20], p = 0.007), and lower QoL (4 [0–6] versus 3 [0–6], p = 0.018). CONCLUSIONS BPH patients with MetS had greater LUTS, particularly irritative symptoms and QoL score. @ 2021 Authors. |
Benign prostate hyperplasia; Lower urinary tract symptoms; Metabolic syndrome |
high density lipoprotein cholesterol; triacylglycerol; Article; body mass; cross-sectional study; glucose blood level; human; human tissue; lower urinary tract symptom; major clinical study; male; metabolic syndrome X; prostate hypertrophy; prostate volume; quality of life; questionnaire; waist circumference |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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346 |
Irawati Y., Gondhowiardjo T.D., Soebono H. |
57201260313;7801650709;6508242918; |
Efficacy and safety of platinum chain and gold weight implants for paralytic lagophthalmos: A systematic review |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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106 |
115 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110572321&doi=10.13181%2fmji.oa.214683&partnerID=40&md5=1e4455ed4f7b0f8707adf603031b37e0 |
Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Department of Dermatovenereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Central General Hospital, Yogyakarta, Indonesia |
Irawati, Y., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Gondhowiardjo, T.D., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soebono, H., Department of Dermatovenereology, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Dr. Sardjito Central General Hospital, Yogyakarta, Indonesia |
BACKGROUND Surgery has been proposed as a treatment of paralytic lagophthalmos. However, no consensus has been reached on the best treatment. This study was aimed to investigate the efficacy and safety between platinum chain and gold weight implants to treat paralytic lagophthalmos. METHODS This study used all randomized controlled trials or observational studies (prospective or retrospective) using platinum chain and gold weight implants for paralytic lagophthalmos surgery that were published from 1990 to 2020 in the PubMed, Cochrane, and Google Scholar databases. Efficacy was indicated by the reduction of ≥3 in lagophthalmos, and safety was measured based on complications after surgery. RESULTS The efficacy of platinum chain and gold weight implants were 60–100% and 10–93.6%, respectively. The complications of platinum chain implant were 0–2.9% of extrusion and 0–3.3% of migration. However, gold weight implant had 0–13.3% of migration. CONCLUSIONS Both platinum chain and gold weight implants have similar efficacy to treat paralytic lagophthalmos. However, gold weight implant has a higher rate of complication. © 2021 Authors. |
Paralytic lagophthalmus; Prostheses and implants; Surgical techniques |
acoustic neuroma; Article; drug efficacy; drug safety; human; lagophthalmos; lid loading technique; paralytic lagophthalmos; systematic review; visual acuity |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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622 |
Budianto I.R., Firmansyah A., Moenadjat Y., Jusuf A.A., Soetikno V. |
56072591000;57430911900;57190371576;57192275719;36769252100; |
In vivo model of Hirschsprung-associated enterocolitis using benzalkonium chloride |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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239 |
244 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123725324&doi=10.13181%2fmji.oa.215339&partnerID=40&md5=0d7ad27ed35c326eece4ebc9bb2d637b |
Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Budianto, I.R., Biomedical Doctoral Program, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Surgery, School of Medicine and Health Sciences, Universitas Katolik Indonesia Atma Jaya, Jakarta, Indonesia; Firmansyah, A., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Moenadjat, Y., Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Jusuf, A.A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND Hirschsprung-associated enterocolitis (HAEC) is a life-threatening complication of Hirschsprung’s disease. Studies using animal models on the pathogenesis of HAEC are limited. Thus, this study aimed to establish a rat model of HAEC using topical application of 0.1% benzalkonium chloride (BAC) in the sigmoid colon. METHODS 55 male Sprague Dawley rats aged 10−12 weeks old were separated into 11 groups. The control group (n = 5) was euthanized on day-7, and the other 10 groups (n = 5 in each group) treated with 0.1% BAC in the sigmoid colon for 15 min to induce Hirschsprung’s disease were euthanized on day-7,-10,-12,-14,-17,-19,-21,-23,-25, and-28. The sigmoid colon was excised, fixed in formalin, and sectioned for histological examinations with hematoxylin and eosin staining. The degree of HAEC was compared within all groups. RESULTS Rats that were sacrificed on day-7 to-12 showed the 1st degree or early HAEC, which was most likely caused by BAC application. The 2nd degree of HAEC occurred in rats that were sacrificed on day-14 that showed a macrophage infiltration in the sigmoid colon, thus fulfilled the initial criteria for HAEC (p = 0.0025 versus control). The degree of enterocolitis increased with time, and the highest degree was found in rats that were sacrificed on day-28 (p<0.001 versus control). CONCLUSIONS Topical application of 0.1% BAC for 15 min was successfully produced HAEC model in rats, which was occurred on day-14 after the application. This model provides a useful resource for further research on the pathogenesis of HAEC. © 2021 Authors. |
Animal model; Colitis; Ganglions; Hirschsprung’s disease |
benzalkonium chloride; eosin; hematoxylin; isoflurane; ketamine; xylazine; aganglionosis; animal model; animal tissue; anorexia; Article; autopsy; cell proliferation; cervical spine dislocation; controlled study; crypt cell; enterocolitis; Hirschsprung disease; in vivo study; laparotomy; macrophage; male; mucosa ulceration; necrosis; neutrophil chemotaxis; nonhuman; rat; sham procedure; sigmoid; Sprague Dawley rat; ulcer |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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623 |
Winarto H. |
54080645300; |
The importance of identification for a stress urinary incontinence after pelvic orgaprolapse vaginal repair |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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237 |
238 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123709235&doi=10.13181%2fmji.ed.215971&partnerID=40&md5=ee09f6c4f49a5e6e13609c2191a488f0 |
Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Winarto, H., Medical Journal of Indonesia, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
[No abstract available] |
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editorial; Editorial; female; human; pelvic organ prolapse; postoperative complication; stress incontinence; vagina reconstruction |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Editorial |
Q4 |
164 |
21905 |
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624 |
Djusad S., Nizomy I.R., Hakim S., Priyatini T., Moegni F., Meutia A.P., Imsantoso B. |
57192276788;57267769100;57192276095;57192265423;55450456100;57203368133;57431312700; |
Incidence and characteristics of de novo stress urinary incontinence after pelvic organ prolapse vaginal repair |
2021 |
Medical Journal of Indonesia |
30 |
4 |
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245 |
249 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123677566&doi=10.13181%2fmji.oa.204163&partnerID=40&md5=9b2deb933d7d42f78f8cd27103bdad59 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia |
Djusad, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nizomy, I.R., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Lambung Mangkurat, Ulin General Hospital, South Kalimantan, Indonesia; Hakim, S., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priyatini, T., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Moegni, F., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meutia, A.P., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Imsantoso, B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND Some patients who undergo pelvic floor reconstruction for pelvic organ prolapse (POP) may experience a de novo stress urinary incontinence (SUI) postoperatively. We aimed to investigate the incidence and characteristics of de novo SUI in patients who underwent pelvic floor reconstruction at the national referral hospital in Indonesia. METHODS This cross-sectional study evaluated 108 patients who underwent pelvic floor reconstruction due to POP between January 2016 and December 2017. Per the inclusion criteria, 75 women were enrolled using a consecutive sampling. The incidence of de novo SUI was determined 6–12 months postoperatively using the Indonesian version of the questionnaire for urinary incontinence diagnosis and objectively using the cough stress test during gynecologic examination after a negative preoperative prolapse reduction stress test. RESULTS The average age, parity, body mass index, and years since menopause onset were 56.17 (4.67) years, 3.17 (1.07), 28.58 (5.18) kg/m2, and 12.8 (7.0) years, respectively. De novo SUI was seen in 8.0% (6 of 75) patients at 6–7 months postoperatively, with 3 (50.0%) had severe POP and 3 (50.0%) had a mild POP. Most of these patients (4 of 6, 66.7%) had undergone procedures other than colpocleisis for POP reconstruction. CONCLUSIONS The incidence of de novo SUI after gynecologic surgery for POP at a national referral hospital in Indonesia is 8%. Most patients were aged <60 years, had a parity of <4, were nonobese, were menopausal, and had diabetes. © 2021 Authors. |
Gynecologic surgery; Pelvic organ prolapse; Tertiary referral center; Urinary stress incontinence |
adult; Article; bladder function test; body mass; cough stress test; cross-sectional study; diabetes mellitus; female; gynecological examination; human; incidence; major clinical study; middle aged; parity; pelvic organ prolapse; preoperative prolapse reduction stress test; stress incontinence; vagina reconstruction |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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745 |
Syam A.F. |
8443384400; |
Gastrointestinal disorders in covid-19 patients: A great imitator |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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166 |
169 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111112690&doi=10.13181%2fmji.bc.204960&partnerID=40&md5=1e55d25030cd22add972a3dac84c5ac5 |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Syam, A.F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Up to this point, the coronavirus disease 2019 (COVID-19) pandemic is still ongoing. Some studies with a large number of cases have reported its clinical manifestations, concluding that the disease is a great imitator. Patients may present with symptoms other than the main symptoms of respiratory tract infections, such as diarrhea, abdominal pain, nausea, or vomiting, which may sometimes cause a delayed treatment in managing COVID-19 patients. Reports of various hospitals have also demonstrated gastrointestinal complaints as a clinical manifestation in those patients. The patients may come with gastrointestinal symptoms as their early clinical manifestation, or the gastrointestinal symptoms may be found in hospitalized COVID-19 patients, which indeed can be explained since the SARS-CoV-2, an etiologic agent of COVID-19 infection, can obviously be found along the gastrointestinal tract. Hence, the virus can be found in fecal and anal, and therefore, rectal swabs can be used as a diagnostic tool for COVID-19 infection. © 2021 Author. |
COVID-19; Gastrointestinal disease; SARS-CoV-2 |
alkaline phosphatase; angiotensin converting enzyme 2; aspartate aminotransferase; transmembrane protease serine 2; virus RNA; anal swab; Article; coronavirus disease 2019; coughing; diabetes mellitus; diarrhea; dyspnea; epigastric pain; feces analysis; fever; gastrointestinal disease; gastrointestinal symptom; gastrointestinal tract; human; hypertension; inflammatory bowel disease; lung lavage; nasopharyngeal swab; nausea and vomiting; nonhuman; pneumonia; real time reverse transcription polymerase chain reaction; rectal swab; RNA virus; Severe acute respiratory syndrome coronavirus 2; stomach pain; thorax radiography; virus transmission |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Article |
Q4 |
164 |
21905 |
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751 |
Soetikno V. |
36769252100; |
The importance of registry for systematic review and clinical trial |
2021 |
Medical Journal of Indonesia |
30 |
2 |
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87 |
88 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110707318&doi=10.13181%2fmji.ed.215620&partnerID=40&md5=f191fe1a910178e15d2b72bb4de9df1c |
Medical Journal of Indonesia, Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Soetikno, V., Medical Journal of Indonesia, Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
[No abstract available] |
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placebo; Cochrane Library; controlled study; data extraction; Editorial; erectile dysfunction; evaluation study; health care policy; human; medical literature; Medline; mesenchymal stem cell; meta analysis; outcome assessment; Preferred Reporting Items for Systematic Reviews and Meta-Analyses; publication; publication bias; questionnaire; randomized controlled trial; register; review; risk assessment; search engine; systematic review |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Editorial |
Q4 |
164 |
21905 |
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815 |
Permata T.B.M., Sekarutami S.M., Nuryadi E., Giselvania A., Gondhowiardjo S. |
57197808751;56576294500;57197806814;57217201891;6508327402; |
Rapid advancement in cancer genomic big data in the pursuit of precision oncology |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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81 |
85 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105003444&doi=10.13181%2fmji.rev.204250&partnerID=40&md5=ac20a978c8162343bd2dd077ffd5908e |
Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sekarutami, S.M., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Giselvania, A., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
In the current big data era, massive genomic cancer data are available for open access from anywhere in the world. They are obtained from popular platforms, such as The Cancer Genome Atlas, which provides genetic information from clinical samples, and Cancer Cell Line Encyclopedia, which offers genomic data of cancer cell lines. For convenient analysis, user-friendly tools, such as the Tumor Immune Estimation Resource (TIMER), which can be used to analyze tumor-infiltrating immune cells comprehensively, are also emerging. In clinical practice, clinical sequencing has been recommended for patients with cancer in many countries. Despite its many challenges, it enables the application of precision medicine, especially in medical oncology. In this review, several efforts devoted to accomplishing precision oncology and applying big data for use in Indonesia are discussed. Utilizing open access genomic data in writing research articles is also described. © 2021 Authors. |
Cancer genetic database; Oncology; Personalized medicine |
adult; big data; cancer cell line; clinical practice; controlled study; genetic database; human; human cell; immunocompetent cell; Indonesia; personalized medicine; review; writing |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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816 |
Pratomo I.P., Ariane A., Tedjo A., Heryanto R., Paramita R.I. |
57192904477;57210643323;57189320451;23392757600;54882436900; |
Xanthine oxidase inhibition in sars-cov-2 infection: The mechanism and potency of allopurinol and febuxostat in covid-19 management |
2021 |
Medical Journal of Indonesia |
30 |
1 |
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75 |
80 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104949199&doi=10.13181%2fmji.rev.204641&partnerID=40&md5=689e842e1dfa9cde24da9c6f8f7bbee1 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia; Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia |
Pratomo, I.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Universitas Indonesia Hospital, Depok, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ariane, A., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Cipto Mangunksumo Hospital, Jakarta, Indonesia; Tedjo, A., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Heryanto, R., Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas IPB, Bogor, Indonesia, Tropical Biopharmaca Research Center, Universitas IPB, Bogor, Indonesia; Paramita, R.I., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute-Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
The number of coronavirus disease 2019 (COVID-19) infection cases has been increasing globally, including in Indonesia. Definitive therapy for COVID-19 has not yet been found; hence, repurposed drugs for COVID-19 have been considered and have been practiced by several researchers in the world. This literature review investigates the action of xanthine oxidase as a component of the biomolecular pathway against severe acute respiratory syndrome-related coronavirus-2, the cause of COVID-19, and describes the mechanism and potential of uric acid drugs (allopurinol and febuxostat) as prophylaxis and curative therapy for COVID-19. © 2020 Authors. |
COVID-19; Free radicals; Uric acid; Xanthine oxidase |
allopurinol; C reactive protein; febuxostat; free radical; gamma interferon; interleukin 2; interleukin 6; reactive oxygen metabolite; uric acid; xanthine oxidase; animal model; coronavirus disease 2019; cytokine production; cytokine storm; drug potency; epithelium; influenza; mouse; neutrophil; nonhuman; oxidative stress; pathogenesis; poultry; respiratory virus; Review; Severe acute respiratory syndrome coronavirus 2; virus infection |
Faculty of Medicine, Universitas Indonesia |
08531773 |
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Review |
Q4 |
164 |
21905 |
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