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141 |
Findyartini A., Raharjanti N.W., Greviana N., Prajogi G.B., Setyorini D. |
56543777300;57226872499;57197709749;57221911632;57218906783; |
Development of an app-based e-portfolio in postgraduate medical education using entrustable professional activities (Epa) framework: Challenges in a resource-limited setting |
2021 |
Asia Pacific Scholar |
6 |
4 |
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92 |
106 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119047428&doi=10.29060%2fTAPS.2021-6-4%2fOA2459&partnerID=40&md5=6cdd410ca553690d4851ccd981856007 |
Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia; Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Oncology Radiation, Faculty of Medicine, Universitas Indonesia, Indonesia |
Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Raharjanti, N.W., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Indonesia; Greviana, N., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia, Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Prajogi, G.B., Department of Oncology Radiation, Faculty of Medicine, Universitas Indonesia, Indonesia; Setyorini, D., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction: E-portfolio may facilitate the entrustment process from supervisors to residents in postgraduate medical education. The present study was aimed at identifying necessary features of an e-portfolio application and to conduct pilot study in a teaching hospital. Methods: Six programs participated. Eight interviews with education directors and six focus group discussions with residents and supervisors were completed for the needs analysis stage. The application was developed based on the thematic analysis of the needs analysis stage. The mobile-app e-portfolio pilot was conducted for four weeks and a modified version of the System Usability Scale (SUS) was distributed to participants following the pilot program. Results: Key features of the e-portfolio were identified. A total of 45 supervisors and 66 residents participated in the pilot study. The residents utilised the application according to the clinical activities and supervision level, and the information was fed to the supervisors as per the application design. Challenges during the pilot study in terms of feedback provision and residents’ workload which influence the e-portfolio use for entrustment decisions are discussed. Conclusion: Current e-portfolio features were created for supervision and are potential to facilitate the entrustment process in Entrustable Professional Activities (EPA) implementation. The pilot study highlighted challenges of the implementation which should be considered for future improvement. © 2021 TAPS. All rights reserved. |
E-Portfolio; Entrustable Professional Activities; Needs Analysis; Pilot Study; Postgraduate Medical Education; Supervision |
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National University of Singapore, Faculty of Law |
24249335 |
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Article |
#N/A |
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746 |
Schuwirth L., Findyartini A. |
7003825152;56543777300; |
Never waste a good crisis: Resilient health professions education |
2021 |
Asia Pacific Scholar |
6 |
3 |
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1 |
4 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111073193&doi=10.29060%2fTAPS.2021-6-3%2fEV6N3&partnerID=40&md5=9a31005ce32498af7be04ec902845ab8 |
Prideaux Centre for Research in Health Professions Education, College of Medicine and Public Health, Flinders University, Australia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia |
Schuwirth, L., Prideaux Centre for Research in Health Professions Education, College of Medicine and Public Health, Flinders University, Australia; Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Indonesia |
[No abstract available] |
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National University of Singapore, Faculty of Law |
24249335 |
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Editorial |
#N/A |
#N/A |
#N/A |
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904 |
Widaty S., Soebono H., Sunarto, Emilia O. |
57208261546;6508242918;57221528270;6504322013; |
Development of a new instrument to assess clinical performance of residents in dermatology-Venereology department |
2021 |
Asia Pacific Scholar |
6 |
1 |
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70 |
82 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099335332&doi=10.29060%2fTAPS.2021-6-1%2fOA2241&partnerID=40&md5=7ccb3f67cc4a32f511df79fd292001b5 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Widaty, S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Indonesia; Soebono, H., Department of Dermatology and Venereology Faculty of Medicine, Universitas Gadjah Mada, Indonesia; Sunarto, Pediatric Department, Faculty of Medicine, Universitas Gadjah Mada Indonesia, Indonesia; Emilia, O., Medical Education Department, Faculty of Medicine, Universitas Gadjah Mada, Indonesia |
Introduction: Performance assessment of residents should be achieved with evaluation procedures, informed by measured and current educational standards. The present study aimed to develop, test, and evaluate a psychometric instrument for evaluating clinical practice performance among Dermatology and Venereology (DV) residents. Methods: This is a qualitative and quantitative study conducted from 2014 to 2016. A pilot instrument was developed by 10 expert examiners from five universities to rate four video-recorded clinical performance, previously evaluated as good and bad performance. The next step was the application of the instrument to evaluate the residents which was carried out by the faculty of DV at two Universities. Results: The instrument comprised 11 components. There was a statistically significant difference (p < 0.001) between good and bad performance. Cronbach’s alpha documented high overall reliability (α = 0.96) and good internal consistency (α = 0.90) for each component. The new instrument correctly evaluated 95.0% of poor performance. The implementation study showed that inter-rater reliability between evaluators range from low to high (correlation coefficient α =0.79, p < 0.001). Conclusion: The instrument is a reliable and valid instrument for assessing clinical practice performance of DV residents. More studies are required to evaluate the instrument in different situation. © 2021 TAPS. All rights reserved. |
Clinical Assessment; Dermatology-Venereology; Instrument; Performance; Resident; Workplace-Based Assessment |
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National University of Singapore, Faculty of Law |
24249335 |
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Article |
#N/A |
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#N/A |
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56 |
Gunardi E.R., Surya R., Syafitri I., Pasidri Y. |
57192910998;56986345100;57195381844;57226151144; |
Impact of one-rod levonorgestrel implant on the blood chemistry profile |
2021 |
Scientific Reports |
11 |
1 |
20141 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116742568&doi=10.1038%2fs41598-021-99801-z&partnerID=40&md5=604f40cda19708636ac9b97fd82f17a7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syafitri, I., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The aim of this study was to investigate the effect of a one-rod levonorgestrel implant on the blood chemistry profile, including random blood glucose (RBG), haemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and the lipid profile, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta, from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated every 6 month up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. p < 0.05 was considered a significant value. The Hb, RBG, AST, and lipid profile levels were significantly different before and 6 months after one-rod implant insertion (p < 0.05). However, for 24 months, all of the parameters were still within normal limits and did not differ clinically. One-rod levonorgestrel implant insertion has a minimal effect on all blood chemistry profiles. © 2021, The Author(s). |
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cholesterol; contraceptive agent; high density lipoprotein cholesterol; levonorgestrel; lipid; low density lipoprotein cholesterol; triacylglycerol; adult; blood; blood analysis; drug implant; female; human; phase 2 clinical trial (topic); procedures; prospective study; young adult; Adult; Blood Chemical Analysis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase II as Topic; Contraceptive Agents, Female; Drug Implants; Female; Humans; Levonorgestrel; Lipids; Prospective Studies; Triglycerides; Young Adult |
Nature Research |
20452322 |
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34635768 |
Article |
Q1 |
1240 |
3130 |
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63 |
Irwinda R., Hiksas R., Siregar A.A., Saroyo Y.B., Wibowo N. |
57190855256;57226152029;57226157581;57164888400;15049026900; |
Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study |
2021 |
Scientific Reports |
11 |
1 |
14701 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110662198&doi=10.1038%2fs41598-021-93846-w&partnerID=40&md5=f379da0f3a9e78e16af9cc0ca6bb9968 |
Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Siregar, A.A., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status. © 2021, The Author(s). |
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unsaturated fatty acid; adult; blood; case control study; cross-sectional study; female; human; Indonesia; male; newborn; nutritional status; pathology; preeclampsia; pregnancy; prematurity; severity of illness index; young adult; Adult; Case-Control Studies; Cross-Sectional Studies; Fatty Acids, Unsaturated; Female; Humans; Indonesia; Infant, Newborn; Male; Nutritional Status; Pre-Eclampsia; Pregnancy; Premature Birth; Severity of Illness Index; Young Adult |
Nature Research |
20452322 |
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34282168 |
Article |
Q1 |
1240 |
3130 |
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65 |
Setiawan E.A., Rianda D., Kadim M., Meilianawati, Susanto F., Kok F.J., Shankar A.H., Agustina R. |
57214103232;57214119630;26644177600;57224214324;57224212671;56506613800;7005442634;57214141404; |
Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence |
2021 |
Scientific Reports |
11 |
1 |
11860 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107265110&doi=10.1038%2fs41598-021-88819-y&partnerID=40&md5=ffa4a369e5635d1edafff9d5559b7d3c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Setiawan, E.A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Rianda, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kadim, M., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Susanto, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Kok, F.J., Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Shankar, A.H., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Microbiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents. Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289. © 2021, The Author(s). |
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lactulose; mannitol; probiotic agent; administration and dosage; adolescent; body height; body mass; body weight; calcium intake; controlled study; diet therapy; dietary supplement; double blind procedure; epidemiology; female; follow up; fortified food; health auxiliary; human; Indonesia; Lactobacillus casei; Lactobacillus reuteri; male; nutritional status; randomized controlled trial; risk factor; statistical model; Adolescent; Body Height; Body Mass Index; Body Weight; Calcium, Dietary; Community Health Workers; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies; Food, Fortified; Humans; Indonesia; Lactobacillus casei; Lactobacillus reuteri; Lactulose; Linear Models; Male; Mannitol; Nutrition Therapy; Nutritional Status; Probiotics; Risk Factors |
Nature Research |
20452322 |
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34088920 |
Article |
Q1 |
1240 |
3130 |
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74 |
Darmadi J., Batubara R.R., Himawan S., Azizah N.N., Audah H.K., Arsianti A., Kurniawaty E., Ismail I.S., Batubara I., Audah K.A. |
57222431230;57220745212;57222422725;57191927056;57222432027;36124567000;57214889313;7103005751;26031903000;15119028200; |
Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug |
2021 |
Scientific Reports |
11 |
1 |
6080 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102715983&doi=10.1038%2fs41598-021-85383-3&partnerID=40&md5=0ea6644166c67e4defd273cae7f6aa43 |
Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia; Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Darmadi, J., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Batubara, R.R., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Himawan, S., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Azizah, N.N., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Audah, H.K., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Arsianti, A., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia, Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Kurniawaty, E., Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Ismail, I.S., Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Batubara, I., Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia, Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Audah, K.A., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia, Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug. © 2021, The Author(s). |
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acetic acid; antineoplastic agent; plant extract; adipose tissue; animal; Artemia; chemistry; drug screening; HeLa cell line; HT-29 cell line; human; MCF-7 cell line; Meliaceae; metabolism; neoplasm; plant leaf; stem cell; Acetates; Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Artemia; Drug Screening Assays, Antitumor; HeLa Cells; HT29 Cells; Humans; MCF-7 Cells; Meliaceae; Neoplasms; Plant Extracts; Plant Leaves; Stem Cells |
Nature Research |
20452322 |
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33727582 |
Article |
Q1 |
1240 |
3130 |
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421 |
Teixeira J.C., Jacobs G.S., Stringer C., Tuke J., Hudjashov G., Purnomo G.A., Sudoyo H., Cox M.P., Tobler R., Turney C.S.M., Cooper A., Helgen K.M. |
56290678400;56504646300;7005875885;20435156700;8937651700;56262110300;6603548824;8699959500;55780763900;7003984281;57225849511;6602538000; |
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture |
2021 |
Nature Ecology and Evolution |
5 |
5 |
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616 |
624 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102829045&doi=10.1038%2fs41559-021-01408-0&partnerID=40&md5=0f530b00ed05b700fb2df18763c0144f |
Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Complexity Institute, Nanyang Technological University, Singapore, Singapore; Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; South Australian Museum, Adelaide, SA, Australia; BlueSky Genetics, Ashton, SA, Australia; Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Jacobs, G.S., Complexity Institute, Nanyang Technological University, Singapore, Singapore, Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Stringer, C., Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; Tuke, J., School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Hudjashov, G., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Cox, M.P., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Turney, C.S.M., Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; Cooper, A., South Australian Museum, Adelaide, SA, Australia, BlueSky Genetics, Ashton, SA, Australia; Helgen, K.M., ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia, Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic ‘super-archaic’ species—Homo luzonensis and H. floresiensis—were present around the time anatomically modern humans arrived in the region >50,000 years ago. Intriguingly, contemporary human populations across ISEA carry distinct genomic traces of ancient interbreeding events with Denisovans—a separate hominin lineage that currently lacks a fossil record in ISEA. To query this apparent disparity between fossil and genetic evidence, we performed a comprehensive search for super-archaic introgression in >400 modern human genomes, including >200 from ISEA. Our results corroborate widespread Denisovan ancestry in ISEA populations, but fail to detect any substantial super-archaic admixture signals compatible with the endemic fossil record of ISEA. We discuss the implications of our findings for the understanding of hominin history in ISEA, including future research directions that might help to unlock more details about the prehistory of the enigmatic Denisovans. © 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature. |
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animal; fossil; genetics; hominid; Homo neanderthalensis; human; island (geological); Southeast Asia; Animals; Asia, Southeastern; Fossils; Hominidae; Humans; Islands; Neanderthals |
Nature Research |
2397334X |
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33753899 |
Article |
Q1 |
5822 |
225 |
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