No records
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445 |
Pramono L.A., Yunir E., Tarigan T.J.E., Nusanti S., Aman R.A., Suroyo I. |
37063602400;36520254800;36057746500;57189727162;57226434769;57204106272; |
Giant Recurrence Pituitary Adenoma After Three Times Transphenoidal Removal Surgery, One Craniotomy Procedure, and 30 Doses of External Radiotherapy |
2021 |
Acta medica Indonesiana |
53 |
2 |
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221 |
224 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111572434&partnerID=40&md5=3fbf4691ce27b57e71d3a91134445173 |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia |
Pramono, L.A., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia; Yunir, E.; Tarigan, T.J.E.; Nusanti, S.; Aman, R.A.; Suroyo, I. |
This is a case of 42nd year-old woman with history of sight loss in her both eyes. She experienced headache and visual field decrease gradually since 2014. After several laboratory and imaging examinations, from her dynamic pituitary magnetic resonance imaging (MRI), it is concluded that she had a giant adenoma of the pituitary gland which compressed to her optic chiasm. From her pituitary laboratory hormone panel, it is revealed that the tumor is a non-functioning pituitary adenoma. From the neuro-ophthalmology (campimetry) examinations, she had papillae atrophy in her both eyes and also bilateral temporal hemianopia. |
Giant Recurrence Pituitary Adenoma; Radiotherapy; Transphenoidal Removal Surgery |
adenoma; adult; case report; craniotomy; female; hemianopia; human; hypophysis tumor; nuclear magnetic resonance imaging; optic nerve; pathology; tumor recurrence; Adenoma; Adult; Craniotomy; Female; Hemianopsia; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Optic Nerve; Pituitary Neoplasms |
NLM (Medline) |
01259326 |
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34251352 |
Article |
Q3 |
321 |
14162 |
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446 |
Damanik J., Yunir E. |
57211582841;36520254800; |
Type 2 Diabetes Mellitus and Cognitive Impairment |
2021 |
Acta medica Indonesiana |
53 |
2 |
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213 |
220 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111560209&partnerID=40&md5=8b6a3af63f3b7bd6c8c50f2cf6ec2509 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Damanik, J., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Yunir, E. |
Type 2 diabetes mellitus (T2DM) is strongly associated with lower performance on multiple domains of cognitive function and with structural abnormalities of the brain. With the growing epidemic of diabetes and aging population, neural complications of diabetes are expected to rise and becoming a challenge for future health implications. Understanding pathophysiology, factors associated with this complication, manifestation of cognitive impairment and various metabolic and neuroradiologic markers suggestive of this pathologic condition is crucial for proper management of this potentially debilitating complication of T2DM. This review will discuss briefly important aspects of cognitive impairment in T2DM. |
cognitive impairment; type 2 diabetes mellitus |
biological marker; aged; brain; cognition; human; non insulin dependent diabetes mellitus; pathology; pathophysiology; Aged; Biomarkers; Brain; Cognition; Diabetes Mellitus, Type 2; Humans |
NLM (Medline) |
01259326 |
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34251351 |
Review |
Q3 |
321 |
14162 |
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447 |
Nugroho P., Lydia A., Suhardjono S., Harimurti K. |
55987056300;8451287200;57218776121;23473513200; |
Association of BsmI Polymorphisms in the Vitamin D Receptor Gene Among Indonesian Population with Diabetic Kidney Disease |
2021 |
Acta medica Indonesiana |
53 |
2 |
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149 |
155 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111468637&partnerID=40&md5=791ec67dac5f5065a522a04484329da4 |
Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia |
Nugroho, P., Division of Nephrology and Hypertension, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Dr Cipto Mangunkusumo HospitalJakarta, Indonesia; Lydia, A.; Suhardjono, S.; Harimurti, K. |
BACKGROUND: Diabetic kidney disease (DKD), as a common cause of end-stage renal disease (ESRD), is a chronic complication of diabetes mellitus (DM). It has been established that vitamin D deficiency is one of DKD risk factors, which may be related to vitamin D receptor (VDR) polymorphisms. This study aimed to analyze the association between VDR polymorphisms and DKD in Indonesian population, also risk factors that influence it. METHODS: a cross-sectional study was conducted in Type 2 DM patients who visited internal medicine outpatient clinic at Dr. Cipto Mangunkusumo Hospital, Jakarta, from November 2014 until March 2015. Data collection includes characteristics of subjects and laboratory examination, including BsmI polymorphisms in the vitamin D receptor gene. Patients with acute and severe disease were excluded from the study. Bivariate and multivariate analyses were done. RESULTS: of 93 DM subjects, 42 (45.2%) subjects were without DKD and 51 (54.8%) subjects had DKD. Most of the subjects had the Bb genotype (89.2%), with no subject having the BB genotype. The proportions of the B and b alleles were 44.6% and 55.4%, respectively. There is no association between BsmI polymorphisms in the vitamin D receptor gene and DKD (OR = 1.243; CI 95% 0.334-4.621; p value = 0.751). CONCLUSION: the profile of BsmI polymorphisms in the vitamin D receptor gene in the Indonesian population were genotypes Bb (89.2%) and bb (10.8%). There was no association between BsmI polymorphisms in the vitamin D receptor gene and DKD. Duration of DM more than five years influenced the association between those variables. |
BsmI; diabetic kidney disease; Indonesia-Malay race; polymorphisms; vitamin D receptor (VDR) gene |
calcitriol receptor; VDR protein, human; aged; blood; case control study; complication; cross-sectional study; diabetic nephropathy; female; genetic polymorphism; genetics; genotype; human; Indonesia; male; middle aged; non insulin dependent diabetes mellitus; risk factor; very elderly; Aged; Aged, 80 and over; Case-Control Studies; Cross-Sectional Studies; Diabetes Mellitus, Type 2; Diabetic Nephropathies; Female; Genotype; Humans; Indonesia; Male; Middle Aged; Polymorphism, Genetic; Receptors, Calcitriol; Risk Factors |
NLM (Medline) |
01259326 |
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34251342 |
Article |
Q3 |
321 |
14162 |
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448 |
Syam A.F., Pitoyo C.W., Suhendro S., Zulkarnain B., Indrasari N.D., Aditianingsih D., Irawan C., Susilo A., Rumende C.M., Wijaya I.P., Ibrahim F., Rasmin M., Alwi I., Makmun D. |
8443384400;26022606900;8443626100;57226403717;6506289872;56312263600;28767651600;57217867079;14325966300;57221504958;57226400046;15754578700;15055173800;16638046900; |
Tocilizumab as a Treatment for 'Cytokine Storm Syndrome' in COVID-19: A Case Report |
2021 |
Acta medica Indonesiana |
53 |
2 |
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194 |
201 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111460182&partnerID=40&md5=9fddc7ae8a7dbf93ea0a07158c0ab2b2 |
Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Syam, A.F., Fellow of the American College of Physicians; Division of Gastroenterology, Dept. of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pitoyo, C.W.; Suhendro, S.; Zulkarnain, B.; Indrasari, N.D.; Aditianingsih, D.; Irawan, C.; Susilo, A.; Rumende, C.M.; Wijaya, I.P.; Ibrahim, F.; Rasmin, M.; Alwi, I.; Makmun, D. |
Coronavirus disease 19 (COVID-19) which is caused by Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2), has been a problem worldwide, particularly due to the high rate of transmission and wide range of clinical manifestations. Acute respiratory distress syndrome (ARDS) and multiorgan failure are the most common events observed in severe cases and can be fatal. Cytokine storm syndrome emerges as one of the possibilities for the development of ARDS and multiorgan failure in severe cases of COVID-19. This case report describes a case of a 53-year-old male patient who has been diagnosed with COVID-19. Further evaluation in this patient showed that there was a marked increase in IL-6 level in blood accompanied with hyperferritinemia, which was in accordance with the characteristic of cytokine storm syndrome. Patient was treated with tocilizumab, a monoclonal antibody and is an antagonist to IL-6 receptor. The binding between tocilizumab and IL-6 receptors effectively inhibit and manage cytokine storm syndrome. Although this case report reported the efficacy of tocilizumab in managing cytokine storm syndrome, tocilizumab has several adverse effects requiring close monitoring. Further clinical randomized control trial is required to evaluate the efficacy and safety of tocilizumab administration in participants with various clinical characteristics and greater number of subjects. |
acute respiratory distress syndrome (ARDS); COVID-19; SARS-CoV-2; Tocilizumab |
biological marker; interleukin 6; monoclonal antibody; tocilizumab; blood; case report; complication; cytokine release syndrome; human; male; middle aged; Antibodies, Monoclonal, Humanized; Biomarkers; COVID-19; Cytokine Release Syndrome; Humans; Interleukin-6; Male; Middle Aged; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34251348 |
Article |
Q3 |
321 |
14162 |
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449 |
Rumende C.M. |
14325966300; |
Pulmonary Fibrosis Caused by Severe COVID-19 Infection: Discharge May Not Be The End of Treatment |
2021 |
Acta medica Indonesiana |
53 |
2 |
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141 |
142 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111424385&partnerID=40&md5=313ffbbdaf35e6b4ca2305e0cfcfa1a4 |
Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Rumende, C.M., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Since December 2019, COVID-19 caused by SARS-CoV-2 infection has been spread rapidly in the world. Beside acute respiratory distress syndrome found in acute phase of infection, there is also pulmonary fibrosis as a chronic complication due to COVID-19. With the global pandemic of COVID-19, more and more autopsy and puncture histopathological results have been published.Until now there is no specific therapy to handle post-inflammatory pulmonary fibrosis due to COVID-19 infection. Several studies are ongoing to determine an effective treatment for this chronic complication. While ARDS appears to be the main cause of pulmonary fibrosis in COVID-19, the pathogenesis of ARDS caused by SARS-CoV-2 is different from the typical ARDS. Some therapies may be considered for reducing the fibrosis process in lung after COVI-19 infection namely pirfenidone, nintedanib and mesenchymal stem cells. Many patients are still recovering spontaneously in the first six weeks after acute COVID-19 infection and do not generally require fast-track entry into a pulmonary rehabilitation programme. However, those who have significantly persistent respiratory illness may need to be supported by pulmonary rehabilitation. Multidisciplinary intervention based on personalized evaluation and treatment which includes exercise training, education and behavioral modification can be given to improve the physical and psychological condition of patients with post-COVID pulmonary fibrosis. |
COVID-19; Indonesia; pulmonary fibrosis |
complication; hospital discharge; human; lung fibrosis; pandemic; virology; virus pneumonia; COVID-19; Humans; Pandemics; Patient Discharge; Pneumonia, Viral; Pulmonary Fibrosis; SARS-CoV-2 |
NLM (Medline) |
01259326 |
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34251340 |
Editorial |
Q3 |
321 |
14162 |
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494 |
Turu' Allo I.J., Santoso A., Findyartini A. |
57222645159;36905206100;56543777300; |
Cardiology trainees' attitudes towards clinical supervision: a scale development study |
2021 |
International journal of medical education |
12 |
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38 |
44 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103608400&doi=10.5116%2fijme.604a.4964&partnerID=40&md5=d05fe194366331389db166e4ab3e2b62 |
Medical Education Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Department of Cardiology-Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Centre-Harapan Kita HospitalJakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Turu' Allo, I.J., Medical Education Centre, School of Medicine, University of Nottingham, Nottingham, United Kingdom; Santoso, A., Department of Cardiology-Vascular Medicine, Faculty of Medicine, Universitas Indonesia/National Cardiovascular Centre-Harapan Kita HospitalJakarta, Indonesia; Findyartini, A., Department of Medical Education, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Objectives: This study aims to explore the construct validity, dimensionality, and internal consistency of a new attitude scale for measuring cardiology trainees' attitudes towards clinical supervision. Methods: A multi-centred, cross-sectional study involving 388 Indonesian cardiology trainees from eight universities was conducted using convenience sampling. Twenty-nine items have been generated based on an extensive literature review and conceptual framework of effective clinical supervision. Ten clinical experts reviewed the items to ensure the Cardiology Clinical Supervision Scale (CCSS) adequately represents the construct under study. An exploratory factor analysis using principal axis factoring (PAF) with oblique rotation was run to identify the internal structure of the scale. Items with factor loading <0.50 were deleted. In addition, inter-item correlations and items' communalities were analysed. Each subscale's internal consistency was assessed using Cronbach's alpha score. Results: The content validity index provided evidence for CCSS' validity (G-coefficient=0.71). Scrutinising the experts' comments, we finalised the scale to include 27 items. Further, four items were deleted due to low inter-item correlation and communality. PAF analysis resulted in a two-factor model comprising the "Supervisory Interaction and Facilitation" factor (n=10 items) and the "Role Modelling" factor (n=9 items); four items were deleted due to low factor loading. The Cronbach's alpha score for SIF and RM factors were 0.93 and 0.89, respectively. Conclusions: The study's results support the validity, internal structure, and internal consistency of the new clinical supervision scale for cardiology training. Further studies are required to investigate other validity and reliability evidence for CCSS, including its cross-cultural validity. |
cardiology training; clinical supervision; scale development |
attitude; cardiology; cross-sectional study; human; psychometry; questionnaire; reproducibility; Attitude; Cardiology; Cross-Sectional Studies; Humans; Psychometrics; Reproducibility of Results; Surveys and Questionnaires |
NLM (Medline) |
20426372 |
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33772563 |
Article |
Q2 |
592 |
8541 |
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603 |
Clarissa A., Sutandi N., Fath A.A. |
57201653912;57201654034;57257442900; |
Stem-Cell Therapy Following High-Dose Chemotherapy in Advanced Retinoblastoma: A Systematic Review |
2021 |
Asia-Pacific journal of ophthalmology (Philadelphia, Pa.) |
10 |
4 |
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397 |
407 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114846321&doi=10.1097%2fAPO.0000000000000372&partnerID=40&md5=bd9b021766dfa6bd6c9f108c62bd4c7c |
Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Clarissa, A., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Sutandi, N.; Fath, A.A. |
PURPOSE: To analyze the risk and benefit of high-dose chemotherapy followed by stem cell transplantation (HDCT-SCT) treatment in patients with advanced retinoblastoma. DESIGN: Systematic review. METHODS: A comprehensive literature search from 4 online databases, including PubMed, Scopus, EBSCO, and Cochrane was done for original studies evaluating the use of HDCT followed by SCT in the treatment of patients with advanced retinoblastoma. The last search was performed on April 15, 2020. RESULTS: A total of 35 studies consisting of 160 patients were considered suitable for inclusion. After HDCT-SCT treatment, 108/160 (67.5%) patients were alive with no evidence of disease at the last follow-up. The incidence of secondary malignancy in our data was also relatively low, which was 16/160 (10%) patients. The side effects were mainly hematological and gastrointestinal toxicities. The prognosis for metastatic cases especially the one to the central nervous system (CNS) remains poor, as shown in our data that 22 of 44 (50%) patients died due to the evidence of disease, and 12 of 44 (27%) patients acquired CNS relapse and died. CONCLUSIONS: HDCT-SCT is a promising treatment option in patients with advanced retinoblastoma. The use of HDCT-SCT in CNS metastases needs to be carefully considered, possibly by adding thiotepa or topotecan to improve tumor control. Further randomized clinical trials are needed to draw firm conclusion regarding its safety and efficacy. Copyright © 2021 Asia-Pacific Academy of Ophthalmology. Published by Wolters Kluwer Health, Inc. on behalf of the Asia-Pacific Academy of Ophthalmology. |
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antineoplastic agent; human; multimodality cancer therapy; retina tumor; retinoblastoma; stem cell transplantation; tumor recurrence; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Humans; Neoplasm Recurrence, Local; Retinal Neoplasms; Retinoblastoma; Stem Cell Transplantation |
NLM (Medline) |
21620989 |
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33481395 |
Article |
#N/A |
#N/A |
#N/A |
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625 |
Lukito W. |
6701622348; |
Current Evidence in Water and Hydration Science |
2021 |
Annals of nutrition & metabolism |
77 |
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1 |
6 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125594947&doi=10.1159%2f000521769&partnerID=40&md5=dc03696320911a4943e24730854d46e4 |
Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
Lukito, W., Postgraduate Program in Physician Specialist-I in Clinical Nutrition/Department of Nutrition, Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia |
[No abstract available] |
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NLM (Medline) |
14219697 |
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35226915 |
Editorial |
#N/A |
#N/A |
#N/A |
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638 |
Wiyono L., Rocha I.C.N., Cedeño T.D.D., Miranda A.V., Lucero-Prisno Iii D.E. |
57207889054;57406221700;57224097138;57222664687;56051373800; |
Dengue and COVID-19 infections in the ASEAN region: a concurrent outbreak of viral diseases |
2021 |
Epidemiology and health |
43 |
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e2021070 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122549130&doi=10.4178%2fepih.e2021070&partnerID=40&md5=0876d7707a72acb2031f56c5f9268d61 |
Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom; Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Philippines |
Wiyono, L., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Cedeño, T.D.D., School of Medicine, Centro Escolar University, Manila, Philippines; Miranda, A.V., Faculty of Medicine, Universitas IndonesiaJakarta, Indonesia; Lucero-Prisno Iii, D.E., Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, United Kingdom, Faculty of Management and Development Studies, University of the Philippines Open University, Los Baños, Philippines |
Member countries of the Association of Southeast Asian Nations (ASEAN) have faced dengue outbreaks for decades, and the region has one of the highest rates of dengue globally. Outbreaks continue to occur concurrently with the coronavirus disease 2019 (COVID-19) pandemic in the 10 ASEAN countries. Both infectious diseases pose a tremendous burden in these countries related to both infection control and the economy. Increases in the number of dengue cases occurred in part due to disruptions in the pathogen-host-vector relationship caused by changes in human behaviour in response to the COVID-19 pandemic. The spread of dengue was further aggravated by the implementation of lockdowns and social distancing policies. These measures limited the coverage of dengue preventive programs and delayed the medical management of both diseases due to co-infection and misdiagnosis. It is of the utmost importance for the population to remain aware of both diseases, and dengue vector control strategies must be devised to properly address outbreaks using digitalization and remote surveillance. Similarly, critical triage algorithms and further research are also needed to combat co-infection and misdiagnosis. Controlling the spread of COVID-19 though vaccination should also be undertaken to reduce the impact of the pandemic. |
Asia; COVID-19; Dengue; Infection control |
communicable disease control; dengue; epidemic; human; pandemic; Communicable Disease Control; COVID-19; Dengue; Disease Outbreaks; Humans; Pandemics; SARS-CoV-2 |
NLM (Medline) |
20927193 |
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34607402 |
Article |
Q1 |
1109 |
3739 |
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733 |
Maulani C., C Masulili S.L., Santoso W.D., Soedarsono N., Kusdhany L., Auerkari E.I. |
57205060934;57226076327;6506080422;14049161500;55301180900;10139113000; |
Association of subgingival Epstein-Barr virus and periodontitis |
2021 |
F1000Research |
10 |
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414 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112635068&doi=10.12688%2ff1000research.52624.1&partnerID=40&md5=0f76116d02cb7eb0372cd72bb0c00912 |
Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia |
Maulani, C., Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; C Masulili, S.L., Department of Periodontology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Santoso, W.D., Department of Internal Medicine, Faculty of Medicine, Universitas IndonesiaJakarta 10430, Indonesia; Soedarsono, N., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Kusdhany, L., Department of Prosthodontics, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia; Auerkari, E.I., Department of Oral Biology, Faculty of Dentistry, Universitas IndonesiaJakarta 10430, Indonesia |
Background: The Epstein-Barr virus (EBV) is gaining interest as a possible agent in the etiology of periodontitis. Previous studies have shown controversy on whether EBV DNA in the subgingival periodontal pockets is associated with periodontitis. The aim of the present study was to seek the potential relationship between EBV and periodontitis. Methods: Data on socio-demographics, oral health, and periodontal health were recorded, and samples were collected from gingival crevicular fluid, using sterile paper point. This case-control study of 118 participants included 59 subjects with severe periodontitis and 59 control subjects with mild periodontitis. The EBV load was determined by quantitative real-time PCR. Results: EBV DNA was detected in 37.3% of the case samples and in 18.6% of the control samples. There was no significant difference in the load of EBV DNA between severe and mild periodontitis (p>0.05). The observed load of EBV DNA was up to 4.55x10 5 copies/mL. The detected EBV DNA was significantly associated with the plaque index and the oral hygiene index (all p<0.05). Conclusions: A significant association was not found, but EBV might contribute to periodontitis. Gingival crevicular fluid is useful for monitoring the EBV load by the real-time PCR technique. Copyright: © 2021 Maulani C et al. |
Epstein-Barr Virus; Gingival Crevicular Fluid; Periodontitis |
virus DNA; case control study; complication; Epstein Barr virus; Epstein Barr virus infection; human; periodontitis; Case-Control Studies; DNA, Viral; Epstein-Barr Virus Infections; Herpesvirus 4, Human; Humans; Periodontitis |
NLM (Medline) |
20461402 |
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34316360 |
Article |
Q1 |
1099 |
3793 |
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