No records
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619 |
Makkiyah F., Sadewo W., Nurrizka R.H. |
57210232162;55014544900;57210747260; |
Comparative dose of intracarotid autologous bone marrow mononuclear therapy in chronic ischemic stroke in rats |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
A |
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233 |
243 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107180848&doi=10.3889%2foamjms.2021.5675&partnerID=40&md5=a05eb1c39d7b38d60e04285fce893c7d |
Department of Neurosurgery, Faculty of Medicine, UPN Veteran Jakarta, Depok, Indonesia; Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Central Jakarta, Indonesia; Department of Public Health, Universitas Islam Negeri Syarif Hidayatullah Jakarta, South Tangerang, Indonesia |
Makkiyah, F., Department of Neurosurgery, Faculty of Medicine, UPN Veteran Jakarta, Depok, Indonesia; Sadewo, W., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Central Jakarta, Indonesia; Nurrizka, R.H., Department of Public Health, Universitas Islam Negeri Syarif Hidayatullah Jakarta, South Tangerang, Indonesia |
BACKGROUND: Research on chronic ischemic stroke is limited. One of the more promising approaches showing positive effects in the acute stage is mononuclear bone marrow cell therapy. This research may be the first which presents data about the optimum dose of bone marrow mononuclear cells (BM-MNCs) for chronic ischemic stroke in rats and discusses factors influencing recovery in the chronic stage. AIM: To elucidate the optimum dose of BM-MNCs for chronic ischemic stroke and to demonstrate factors influencing recovery in chronic stage of stroke ischemia. METHODS: Thirty-two male Sprague-Dawley rats sourced from the Kalbe Farma Institution (Bandung, Indonesia), aged 6–10 aged months, weighing 350–450 g were used in this study. We performed temporary middle cerebral artery occlusion (MCAO) procedures on the rats which were then randomly assigned to one of two experimental groups in which they were given either low or high doses of autologous BM-MNCs (5 million or 10 million cells per kg body weight intracarotid), after 4 week of MCAO. At 8th or 12 week, rats were necropsied and rat brains were fixed for HE, cluster of differentiation (CD) 31, and doublecortin staining for analysis of the effects. Rat behavior was assessed weekly using the cylinder test and a modified neurological severity score (NSS) test. Cylinder test scores and NSS scores were analyzed by one-way ANOVA repeated measures and post hoc Bonferroni. The size of the infarct zone, the CD 31 vessels, and the DCX-neuroblast were analyzed using one-way ANOVA and a post hoc Bonferroni test. To investigate the degree of correlation between time and dose, two-way ANOVA and simple mass effect analyses were conducted. A linear regression test was used to evaluate the correlation between CD34 and other variables. RESULTS: In the 4 weeks before administration of BM-MNC, cylinder test scores improved to near normal, and NSS test scores improved moderately. The infarct zone decreased significantly (p < 0.01), there was an improvement in angiogenesis (p = 0.1590) and a significant improvement in neurogenesis (p < 0.01). Reduction of the infarct zone was associated with a higher dose whereas both higher and lower doses were found to have a similar effect on improving angiogenesis, and neurogenesis. Recovery was superior after 12 weeks compared with the recovery assessment at 8 weeks. CONCLUSION: A dose of 10 million cells was more effective than a dose of 5 million cells per kg body weight for reducing the infarct zone and ameliorating neurogenesis. There was an improvement of histopathological parameters associated with the longer infarct period. © 2021 Feda Makkiyah, Wismaji Sadewo, Rahmah Hida Nurrizka. |
Bone marrow mononuclear cells; Chronic infarct; Dose; Intracarotid; Rats brain |
CD34 antigen; platelet endothelial cell adhesion molecule 1; adipose derived stem cell; analysis of variance; angiogenesis; animal cell; animal experiment; animal model; animal tissue; arteriotomy; Article; autopsy; body weight; bone marrow derived mononuclear cell; breathing rate; chronic ischemic stroke; controlled study; cylinder test; drug megadose; endothelial progenitor cell; gap junction; histopathology; immunohistochemistry; infarction; interphalangeal joint; intracarotid drug administration; linear regression analysis; low drug dose; micro-computed tomography; middle cerebral artery occlusion; National Institutes of Health Stroke Scale; neuroblast; neurological severity score; nonhuman; rat; Sprague Dawley rat |
Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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876 |
Sari I.P., Audindra S., Zhafira A.S., Rahma A.A., Syarira C.V., Wahdini S. |
57197543698;57222006228;57205515532;57222005612;57222010715;57203684068; |
Nutritional status of school-aged children with intestinal parasite infection in South Jakarta, Indonesia |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
E |
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95 |
100 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100938719&doi=10.3889%2foamjms.2021.5711&partnerID=40&md5=1772780d39afba8ba66dd65e8997f0b4 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sari, I.P., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Audindra, S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Zhafira, A.S., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahma, A.A., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syarira, C.V., Undergraduate Program in Medical Doctor, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahdini, S., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: The prevalence of intestinal parasitic infection still high in Indonesia and lead to nutritional disorder, especially in the school-aged children. AIM: This research conducted to find the association of intestinal parasitic infection to the nutritional status of the children. METHODS: This was a cross sectional study, conducted in January 2016 in one primary school in South Jakarta, Jakarta, Indonesia, by collecting the children’s stool from 1st to 5th grade. Direct examination of the stool was conducted in the Parasitology Department, Faculty of Medicine, Universitas Indonesia, by Lugol and eosin staining. Nutritional status categorized using BMI chart. Data were analyzed using Chi-square test, Statistical Product, and Service Solutions version 20. RESULTS: From the total 157 stool examined in the laboratory, there were 60 (38.2%) children positively infected with various kinds of intestinal parasites. Mostly the infection is caused by Blastocystis hominis, which infects 44 children (69.4%). The other infection is caused by Giardia lamblia (15.3%), Trichuris trichiura (1.4%), and hookworm (1.4%), and mixed infection of B. hominis and Escherichia coli (4.2%) and B. hominis with G. lamblia (4.2%). From the total of infected children, 17 children (28.3%) have BMI below 5th percentile, and it was considered as malnourished. Moreover, 67 uninfected children have normal nutritional status. Statistically, there is an association between intestinal parasitic infection and nutritional status in school-aged children in South Jakarta (P < 0.05). CONCLUSION: The incidence of intestinal parasitic infection in school-aged children is 38.2%. Moreover, 28.3% of the infected children were malnourished and it is suggested that children with intestinal parasite infection have low nutritional status. © 2021 Ika Puspa Sari, Sacha Audindra, Aqila S. Zhafira, Arin A. Rahma, Cut V. Syarira, Sri Wahdini. |
Malnourish; Parasitic Infection; Primary Schools; South Jakarta |
Article; Blastocystis hominis; body mass; child; cross-sectional study; disease association; Escherichia coli; feces analysis; female; Giardia intestinalis; human; Indonesia; intestine parasite; major clinical study; male; malnutrition; mixed infection; nutritional status; obesity; parasitosis; prevalence; primary school; questionnaire; seasonal variation; Trichuris trichiura; underweight |
Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
Q3 |
288 |
15252 |
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890 |
Elliyanti A., Rustam R., Tofrizal T., Yenita Y., Susanto Y.D.B. |
57217097313;57210705603;57219663511;57221789235;57197866044; |
Evaluating the natrium iodide symporter expressions in thyroid tumors |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
B |
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18 |
23 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100161267&doi=10.3889%2foamjms.2021.5534&partnerID=40&md5=f5dd69104ea66dab03a6a98ac2928162 |
Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Elliyanti, A., Department of Medical Physics, Faculty of Medicine, Universitas Andalas, Padang, Indonesia, Division of Nuclear Medicine, Department of Radiology, Dr. M.Djamil Hospital, Padang, Indonesia; Rustam, R., Department of Surgery, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Tofrizal, T., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Yenita, Y., Department of Pathology Anatomy, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Susanto, Y.D.B., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Decreased Natrium iodide symporter (NIS) expression levels or diminished NIS targeting thyroid cancer cells’ plasma membrane leads to radioiodine-refractory disease. AIM: The aim of this study was to analyze the NIS expression in thyroid tumors. MATERIALS AND METHODS: The samples were thyroid tissues of patients who underwent surgery for a thyroid tumor. The tissues were processed for NIS protein expressions by immunohistochemistry (IHC) and Western blot (WB). Graves’ disease samples were used as positive controls. The samples were incubated without the primary antibody, and they were used as negative controls for IHC examination. Na+/K+ ATPase was a plasma membrane protein marker in the WB procedure. RESULTS: Twenty-nine samples were assessed for NIS protein. All of them showed the expression in the cytoplasm with intensity 1+ to 3+ with Allred score 3-8. Fourteen out of 29 cases (48.2%) showed NIS cytoplasm staining intensity ≥2+ consist of 10 papillary thyroid cancer (PTC), three follicular thyroid cancer, and one adenoma. Membrane staining was found in 2 samples of PTC (6.9%). Six samples (adenoma 1 sample, PTC 5 samples) showed NIS expression at membrane very weak (1+); they were considered as negative. NIS protein has several bands of ~ 80 kDa, ~ 62 kDa, and ~ 49 kDa. CONCLUSION: NIS expression in thyroid cancer mostly expresses in the cytoplasm instead of the membrane. NIS will play a functional role in the membrane to bring iodine across the membrane against the concentration. It can be the main reason for the lack of response of radioiodine in some differentiated thyroid cancers. © 2021 Aisyah Elliyanti, Rony Rustam, Tofrizal Tofrizal, Yenita Yenita, Susanto YDB. |
Follicular thyroid cancer; Immunohistochemistry; Membrane staining; Papillary thyroid cancer; Western blot |
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Open Access Macedonian Journal of Medical Sciences |
18579655 |
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Article |
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288 |
15252 |
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No records
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98 |
Yusharyahya S.N., Bramono K., Indriatmi W., Prasetyo M., Ascobat P., Hestiantoro A., Wiraguna A.A.G.P. |
57211780941;9843236700;57189888041;57192905252;55795863600;8743255100;20437026700; |
Anti-aging effects of fenugreek cream on postmenopausal skin: A randomized controlled trial |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
11 |
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95 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119480025&doi=10.7324%2fJAPS.2021.1101113&partnerID=40&md5=020217cd5f217dbc98ba3162ac9d99f1 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bramono, K., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Indriatmi, W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Prasetyo, M., Department of Radiology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ascobat, P., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiraguna, A.A.G.P., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Udayana – Sanglah General Hospital, Denpasar, Indonesia |
Postmenopausal hypoestrogenism is associated with skin aging, for which phytoestrogen derived from the seeds of Trigonella foenum graecum (fenugreek) is expected to be an alternative solution to reduce wrinkles and increase the thickness of postmenopausal women’s skin. This study was a randomized, double-blind, controlled 12-weeks trial conducted at a general hospital in Jakarta, Indonesia, from January to November 2019. Subjects were 50 postmenopausal women divided into two groups: the intervention group was given 5% fenugreek cream and base cream was given to the placebo group. The results of the independent t-test showed that both groups were able to achieve statistically significant improvement in wrinkle scores on the forehead, crow’s feet, and nasolabial folds which was assessed by photography scoring based on Bazin’s skin aging atlas for Asian skin volume 2 but there was no significant disparity between both groups at all time points. Dermal thickness was assessed by high-resolution ultrasound GE LOGIQ E9 (18 MHz), which showed similar results for both groups with significant improvements in the 8th week compared to baseline and a significant decrease by the 12th week. No significant differences were observed in the skin wrinkle score and skin thickness after the application of fenugreek cream compared to placebo.We suspect that a concentration of 5% was not adequate for the expected antiskin aging effects. Further studies are necessary to determine a more appropriate fenugreek concentration to permit clinical use as an antiskin aging therapy in postmenopausal women. © 2021 Shannaz Nadia Yusharyahya et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License |
Dermal thickness; fenugreek; postmenopausal skin; skin wrinkle |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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354 |
Wangsaputra V.K., Syarinta S., Louisa M. |
57215576000;57224977663;41461551400; |
Alpha-mangostin Reduces Cell Viability in Sorafenib-surviving Cells by Modulating Multiple Drug Transporters in Hepg2 Hepatocellular Carcinoma Cells |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
6 |
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105 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108813859&doi=10.7324%2fJAPS.2021.110612&partnerID=40&md5=eec4655af84852758d672bc24d8bc83b |
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Wangsaputra, V.K., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Syarinta, S., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
A previous study showed that alpha-mangostin (AM) showed benefit when given to sorafenib (SOR)-surviving cells. However, the mechanism was not fully understood. The present study aimed to understand the effect of AM on SOR-surviving cells and its agent concerning drug transporters. SOR-surviving cells were treated with SOR 10 μM. Surviving cells were divided into four groups of treatment, namely, vehicle only dimethyl sulfoxide (DMSO), SOR 10 μM, AM 20 μM, or combination of SOR 10 μM-AM 20 μM. As controls, HepG2 naïve cells were treated with DMSO only or AM 20 μM. Cell viability was counted using trypan blue exclusion assay. Simultaneously, the mRNA expressions of P-glycoprotein (P-gp), ABCG2, MRP2, MRP3, OCT1, and OATP1B3 drug transporters were examined with quantitative reverse transcriptase-polymerase chain reaction. Decreased mRNA expression of P-gp was found in SOR-surviving cells treated with SOR. In contrast, AM alone or SOR's combination caused a significant increase in both efflux and influx transporters, no difference in fold increase of all transporters evaluated in AM versus SOR-AM combinations. Generally, AM treatment increased the mRNA expression of all the drug transporters. © 2021 Vincent Kharisma Wangsaputra et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Alpha-mangostin; drug transporters; OCT1; P-glycoprotein; sorafenib resistance |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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356 |
Fadilah F., Erlina L., Paramita R.I., Istiadi K.A. |
56966708600;57190181680;54882436900;57224568113; |
Immunoinformatics Studies and Design of Breast Cancer Multiepitope Peptide Vaccines: Diversity Analysis Approach |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
6 |
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035 |
045 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108795156&doi=10.7324%2fJAPS.2021.110604&partnerID=40&md5=36bb41265fd86ae6763c0ce748625cb9 |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Erlina, L., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Istiadi, K.A., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Breast cancer is one of the most diagnosed cancers in women; the number of cases continues to rise. The high prevalence and increased incidence need more attention in developing effective therapy. Current passive therapy has several drawbacks that have not yet been resolved. Thus, an alternative and preventive therapy for cancer is needed by utilizing vaccines. Immunoinformatics approach is one of the promising methods predicting epitopes in vaccine research. This approach could accelerate the initial study process of vaccine development and reduce research costs. Epitope conservancy and vaccine coverage are important parameters in vaccine research due to addressing the variability and diversity of cancer genomics. This study will be carried out on the multiepitope characterization of potential T cells against the protein mechanism in breast cancer. Proteins used in this study are Mucin-4, Phosphatase And Tensin Homolog, and Receptor tyrosine-protein kinase erbB-2. CTL epitopes, antigenicity, immunogenicity, allergenicity, and toxicity were predicted for the peptide vaccine. Immunoinformatics analysis generates a multiepitope sequence consisting of seven epitopes: DPVALVAPF, SVAYRLGTL, SQINTLNTL, RFRELVSEF, VTSANIQEF, RPRFRELVS, and MYFEFPQPL by AAY linker. The docking and molecular dynamics analyses were conducted to confirm the interactions between the multiepitope vaccine molecule and TLR-4-MD. The multiepitope vaccine construct can be an appropriate choice for further experiments. © 2021 Fadilah Fadilah et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Breast cancer; immunoinformatics; multiepitope; peptide vaccine design; vaccine |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
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286 |
15310 |
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463 |
Nurhayati F., Anggriani Y., Syahruddin E., Ramadaniati H.U., Kusumaeni T. |
57222957631;57144482600;6507688750;56380618600;57196083946; |
Cost-effectiveness analysis of tyrosine kinase inhibitors (erlotinib vs. gefitinib vs. afatinib) in non-small-cell lung cancer |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
4 |
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88 |
95 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104274393&doi=10.7324%2fJAPS.2021.110411&partnerID=40&md5=b2ac85fabd74afa9ddcab3ce12766f43 |
Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Division of Thoracic Oncology Department of Pulmonology Respiratory Medicine Faculty of Medicine, Universitas Indonesia Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Nurhayati, F., Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia; Anggriani, Y., Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Syahruddin, E., Division of Thoracic Oncology Department of Pulmonology Respiratory Medicine Faculty of Medicine, Universitas Indonesia Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Ramadaniati, H.U., Faculty of Pharmacy, University of Pancasila, Jakarta Selatan, Indonesia; Kusumaeni, T., Pharmacy Department, Persahabatan Government Hospital, Jakarta, Indonesia |
Tyrosine kinase inhibitors (TKIs; e.g., erlotinib, gefitinib, and afatinib) are the first-line therapy for non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) (+) common mutation. The study’s objective was to analyze the cost-effectiveness of erlotinib, gefitinib, and afatinib in NSCLC patients. The subjects of the study were NSCLC patients with EGFR (+) mutation receiving either erlotinib, gefitinib, or afatinib from January 2017 to December 2019. The exclusion criteria were patients receiving the respective therapy for less than 2 months and patients unable to complete the treatment until after December 2019. The parameter of treatment effectiveness was progression-free survival (PFS), which was measured as the time from initiation of the therapy until disease progression occurred or a patient became deceased. Direct medical costs, from the hospital perspective, were calculated during the treatment. A nonparametric Kruskal-Wallis test was conducted to compare the median PFS and direct medical cost between the three treatment groups. The median PFS of patients receiving erlotinib, gefitinib, and afatinib was 8 months, 12 months, and 5 months, respectively. There were significant differences in the monthly direct medical costs between the study groups: erlotinib (IDR 13,545,116), gefitinib (IDR 14,727,887), and afatinib (IDR 12,146,834). The cost-effectiveness ratio of the study groups was as follows: erlotinib IDR 1,693,139.50/months; gefitinib IDR 1,227,323.92/months; and afatinib IDR 2,429,366.80/months. Gefitinib was the most cost-effective TKI, followed by erlotinib and afatinib. © 2021. Fitri Nurhayati et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). All rights reserved. |
afatinib; Cost-effectiveness; erlotinib; gefitinib; non-smallcell lung cancer. |
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Open Science Publishers LLP Inc. |
22313354 |
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No records
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344 |
Susantiningsih T., Makkiyah F.A., Thadeus M.S., Yulianti R., Hadi S. |
57192907038;57210232162;57226238484;57201696813;26534077400; |
Progressive acute liver damage induced by repeated 2-nitropropane: Focused on obese mice |
2021 |
Biomedical and Pharmacology Journal |
14 |
2 |
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695 |
700 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110971235&doi=10.13005%2fbpj%2f2172&partnerID=40&md5=d967f0ab42728fa05df28dd316a8f615 |
Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia |
Susantiningsih, T., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Makkiyah, F.A., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Yulianti, R., Faculty of Medicine, Universitas Pembangunan Nasional Veteran, Jakarta, 12450, Indonesia; Hadi, S., Department of Chemistry, Universitas Lampung, Bandar Lampung, 35145, Indonesia |
Obesity is linked to more deaths worldwide. In obesity, there will be a dysregulation of growth signals such as tumorigenesis. Despite the fact that obesity is tend to progress to acute liver damage, not many study using 2-nitropropane (2NP) as a hepatoxicity agent are undertaken especially in obese mice. This study aimed to determine the regime of 2NP that causes acute liver damage. This is an experimental research using a post-test control design group only, with 3 groups of mice ie O1 (obesity), O2+2-NP 1x (induced by 2NP 100 mg/kg BW once), and O2+2-NP 2x (induced by 2NP 100 mg/kg BW twice). At 10 weeks, rats were sacrificed and 100 mg liver tissue were collected for MDA, GSH, MnSOD and CAT enzymes analysis. Analysis statistics were performed by SPSS by one-way Anova and post hoc Tukey. MDA levels of mice were found to be increased in 2NP group than control (3.768 ± 0.407 nmol/ mg) (p < 0,01). Liver GSH, MnSOD and CAT levels of both single injection 2-NP and repeated injection 2-NP groups decreased compared to those of controls (p<0,01). Repeated injection of 2-NP worsen the acute liver damage in obese mice. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
2-NP; CAT; GSH; MDA; MnSOD; Obesity |
2 nitropropane; catalase; glutathione peroxidase; ketamine; manganese superoxide dismutase; oxygen; reactive oxygen metabolite; superoxide dismutase; triacylglycerol; xylazine; analysis of variance; animal model; animal tissue; Article; body weight; carcinogenesis; centrifugation; controlled study; data analysis software; DNA damage; enzyme activity; liver injury; liver tissue; male; mouse; nonhuman; obesity; oxidative stress; post hoc analysis; protein content; repeated drug dose |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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524 |
Purwaningsih E.H., Oertl A., Freisleben S.K.U., Freisleben H.-J. |
57186723500;6508320409;57192904042;7003437337; |
How can immunosuppression after organ transplantation be made more effective and safer? - A review on liposomal formulations with consideration of archaeal tetraetherlipid |
2021 |
Biomedical and Pharmacology Journal |
14 |
1 |
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33 |
52 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104470529&doi=10.13005%2fbpj%2f2097&partnerID=40&md5=d0059a38fb0687012c274dcda3c60c0f |
Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Faculty of Medicine, Goethe-University Frankfurt/Main, Germany; Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia |
Purwaningsih, E.H., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Oertl, A., Faculty of Medicine, Goethe-University Frankfurt/Main, Germany, Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Freisleben, S.K.U., Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany, Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia; Freisleben, H.-J., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia, Faculty of Medicine, Goethe-University Frankfurt/Main, Germany |
Immune-suppressive agents such as methylprednisolone and cyclosporine exert tremendous side effects, because of high dosage and long-term application required for immune suppression after organ transplantation. Major side effects of methylprednisolone include bleeding of the gastro-intestinal tract, hypertension, and osteoporosis, whereas cyclosporine is nephrotoxic. Liposomes are phospholipid particles that allow delivery of drugs preferentially to the reticuloendothelial system. They can be prepared from phospholipids, such as lecithin from soybean or egg yolk, other specific or modified lipids or from membrane-spanning tetraether lipid (TEL), which can be extracted and purified from archaeal cell membranes. One advantage in the use of liposomal application is reduced toxicity of many drugs. We report on various liposomal preparations of cyclosporine, methylprednisolone (L-MPL) and its palmitate derivative (L-MPLP). It has been documented that liposomal cyclosporine A (L-CsA), 1.75 mg/kg/ day for seven days has potential for use as an immune-suppressive agent in rats with increased efficacy and decreased nephrotoxicity compared to commercially available forms of intravenous CsA. Liposomal methylprednisolone (L-MPL) 2 mg/kg, intravenously (IV), twice a week shows significantly prolonged cardiac allograft survival in rats and tissue-selective sequestration of the drug in comparison with the same dosage regimen of methylprednisolone in solution, administered daily. We report on organ distribution of L-MPLP in rats after intraperitoneal (IP) administration. Conclusion: Liposomal preparations of immunosuppressants have significantly higher immune-suppressive potential and lower toxicity than non-liposomal preparations. Bipolar TEL can be extracted, fractionated and purified from archaea to form stable liposomes which are extremely resistant, even to gastric fluid. Hence, TEL liposomes allow (besides IV and IP) for oral administration of immunosuppressants after organ transplantation with pharmacological and toxicological advantages over common liposomal phospholipid bilayer preparations. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
Absorption; Allograft; Cyclosporine; Gastrointestinal stability; Immunosuppressant; Liposomes; Methylprednisolone; Oral administration; Organ transplantation; Toxicity |
alamethicin; albumin; cholesterol; coumarin; cyclosporine; dexamethasone; globulin; glucocorticoid; interleukin 1; liposome; lymphokine; methylprednisolone; phosphatidylcholine; phosphatidylglycerol; phospholipid; tumor necrosis factor; affinity chromatography; allograft; archaeon; Article; bioavailability; cytotoxicity; drug release; drug therapy; egg yolk; electron microscopy; encapsulation; fluorescence; gastrointestinal tract; gel filtration chromatography; helper cell; histocompatibility; human; hypertension; immune response; immunological tolerance; immunosuppressive treatment; lipophilicity; liposomal delivery; macrophage; nephrotoxicity; organ transplantation; osteoporosis; phagocytosis; reticuloendothelial system; soybean; stomach juice; T lymphocyte; thin layer chromatography |
Oriental Scientific Publishing Company |
09746242 |
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