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512 |
Inayati R., Suhaeri M., Fahdia N., Remelia M., Antarianto R.D. |
57222623427;56183087500;57222625988;57209653885;57190862806; |
Optimization of hybrid PVA/hFDM scaffold preparation |
2021 |
AIP Conference Proceedings |
2344 |
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020012 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103481516&doi=10.1063%2f5.0049156&partnerID=40&md5=d049606831bf9a961d70f9a9c49ec7bf |
Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Inayati, R., Master Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia; Suhaeri, M., Rumah Sakit Universitas Indonesia, Kampus Universitas Indonesia, Depok, West Java, 16424, Indonesia; Fahdia, N., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia; Remelia, M., Doctoral Program in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia, Department of Basic Biomedicine, Faculty of Medicine, Universitas Kristen Indonesia, Jl Mayjen Sutoyo No 2, DKI Jakarta, 13630, Indonesia; Antarianto, R.D., Stem Cell and Tissue Engineering Research Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Salemba Raya, Jakarta, West Java, 10430, Indonesia, Department of Histology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya No. 6, Central Jakarta, DKI Jakarta, 10430, Indonesia |
Osteogenic differentiation from Mesenchymal Stem Cell (MSC) to osteoblast has a clinical significance which is very important for treating bone injuries, in the form of femoral fractures with the most cases in Indonesia. Various studies have been conducted to find the best scaffold that can improve osteogenic differentiation, one of which is the development of a hybrid scaffold made from natural biomaterials in the form of the extracellular matrix, and from synthetic biomaterials. The discovery of the best scaffold is not only focused on the source of the scaffold but also requires optimization of the method in making the scaffold. Therefore, the aim of this study is to find out the optimum method for making hybrid scaffolds that support osteogenic differentiation from MSC. Materials and methods: human Fibroblast-derived Matrix (hFDM) as a hybrid scaffold material collected from decellularized fibroblasts cultures from post-cleft-surgery reconstruction palatal skin. Fibroblast cell cultures were divided into two groups of cultures, cultures without Platelet Rich Plasma (PRP), and cultures with the addition of PRP. For decellularization, we performed optimization at the preparation stage of the decellularization solution, and the time of culture for decellularization. In the preparation of the decellularization solution, we divided it into two groups, NH4OH as material from the decellularization solution was diluted with PBS before mixing with 0.25% Triton X-100, and NH4OH was diluted directly in 0.25% Triton X-100. In optimizing the culture time for decellularization, we divided it into three groups, decellularization on the day when cell growth reached 100% confluent, decellularization on the 3rd day after 100% confluent (H + 3) cells, and decellularization on the 4th day after 100% confluent (H + 4) cells. Next, the hFDM matrix is collected and added Polyvinyl Alcohol (PVA) solutions to form a hybrid PVA / hFDM scaffold in the form of a hydrogel. Observations on hybrid PVA / hFDM scaffolds were made using an inversion microscope. Results and discussion: Optimization of methods for culture techniques found that the addition of PRP to fibroblast culture medium increased the rate of fibroblast proliferation. For the decellularization technique, it is known that the preparation of the decellular solution by diluting NH4OH directly in 0.25% Triton X-100 to obtain a final concentration of 50mM NH4OH is known to be effectively used in decellularizing fibroblasts. The optimum culture time is also known that a thicker hFDM matrix can be obtained on day 4 after 100% confluent (H + 4) cells. Conclusion: Making a good hFDM hybrid PVA scaffold requires method optimization, ranging from fibroblast culture techniques and decellularization techniques. Proper optimization can produce a hybrid PVA / hFDM scaffold which is suitable for bone tissue engineering applications. © 2021 Author(s). |
decellularization; fibroblast culture; hybrid PVA/hFDM scaffold |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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513 |
Rizal, Syaidah R., Aqsha Z.M., Josephin A., Pakpahan V.M. |
57222623832;55418885900;57222626455;57222619624;57222621602; |
Characterization, differentiation, and population doubling time of Wharton's jelly mesenchymal stem cells (WJ-MSCs) in passage 5 and 8 |
2021 |
AIP Conference Proceedings |
2344 |
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040002 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103479666&doi=10.1063%2f5.0047340&partnerID=40&md5=346f0fd284692390adaef1a8feae20b2 |
Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Rizal, Biomedical Engineering Program, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Syaidah, R., Department of Histology, Faculty of Medicine, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Aqsha, Z.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Josephin, A., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Pakpahan, V.M., Undergraduate Program in Biomedical Engineering, Department of Electrical Engineering, Faculty of Engineering, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia |
Wharton's jelly mesenchymal stem cells (WJ-MSCs) is proposed to be the best source of mesenchymal stem cells (MSCs). It has better self-renewal and differentiation capacity compare to adult stem cells such as bone marrow- derived stem cells (BM-MSCs). However, their characteristics in different passages do not yet well described. This research aims to isolate and characterize WJ-MSCs with regard to their proliferation capacity, immunophenotypes, and differentiation capacity. The WJ-MSCs were isolated by the explant method. The cultured WJ-MSCs at P5 and P8 were then characterized using flow cytometric analysis with regard to its surface marker, which are CD44, CD90, CD105, CD73, and negative lineages. The proliferation capacity of WJ-MSCs was analyzed with the population doubling time method and the characterized cells were differentiated into three different lineages. The result revealed that the isolated cells highly express MSCs surface marker with >98% for all surface markers and 0.00% for negative lineages. Isolated WJ-MSCs also exhibited a high proliferation capacity with a range of 1.06 to 1.59 days. Both passages revealed excellent differentiation capacity into chondrocytes, adipocytes, and osteocytes. © 2021 Author(s). |
characterization; differentiation; Mesenchymal stem cells; proliferation; Wharton's jelly |
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American Institute of Physics Inc. |
0094243X |
9780735440869 |
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Conference Paper |
- |
177 |
20880 |
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514 |
Chang F.-Y., Wiratman W., Ugawa Y., Kobayashi S. |
57195621810;57191920526;7005460744;56508693300; |
Event-Related Potentials During Decision-Making in a Mixed-Strategy Game |
2021 |
Frontiers in Neuroscience |
15 |
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552750 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103554813&doi=10.3389%2ffnins.2021.552750&partnerID=40&md5=ef31052f38e98dcc5c24224d29264efc |
Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan; Department of Neurology, Takeda General Hospital, Fukushima, Japan; Department of Neurology, Teikyo University, Tokyo, Japan |
Chang, F.-Y., Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan; Wiratman, W., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ugawa, Y., Department of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan, Department of Neurology, Takeda General Hospital, Fukushima, Japan; Kobayashi, S., Department of Neurology, Teikyo University, Tokyo, Japan |
The decisions we make are sometimes influenced by interactions with other agents. Previous studies have suggested that the prefrontal cortex plays an important role in decision-making and that the dopamine system underlies processes of motivation, motor preparation, and reinforcement learning. However, the physiological mechanisms underlying how the prefrontal cortex and the dopaminergic system are involved in decision-making remain largely unclear. The present study aimed to determine how decision strategies influence event-related potentials (ERPs). We also tested the effect of levodopa, a dopamine precursor, on decision-making and ERPs in a randomized double-blind placebo-controlled investigation. The subjects performed a matching-pennies task against an opposing virtual computer player by choosing between right and left targets while their ERPs were recorded. According to the rules of the matching-pennies task, the subject won the trial when they chose the same side as the opponent, and lost otherwise. We set three different task rules: (1) with the alternation (ALT) rule, the computer opponent made alternating choices of right and left in sequential trials; (2) with the random (RAND) rule, the opponent randomly chose between right and left; and (3) with the GAME rule, the opponent analyzed the subject’s past choices to predict the subject’s next choice, and then chose the opposite side. A sustained medial ERP became more negative toward the time of the subject’s target choice. A biphasic potential appeared when the opponent’s choice was revealed after the subject’s response. The ERPs around the subject’s choice were greater in RAND and GAME than in ALT, and the negative peak was enhanced by levodopa. In addition to these medial ERPs, we observed lateral frontal ERPs tuned to the choice direction. The signals emerged around the choice period selectively in RAND and GAME when levodopa was administered. These results suggest that decision processes are modulated by the dopamine system when a complex and strategic decision is required, which may reflect decision updating with dopaminergic prediction error signals. © Copyright © 2021 Chang, Wiratman, Ugawa and Kobayashi. |
executive function; feedback; game theory; high-density EEG; levodopa; Parkinson’s disease; prefrontal cortex; readiness potential |
dopamine; levodopa; Article; behavior; clinical article; contingent negative variation; controlled study; diffusion weighted imaging; dopaminergic system; electroencephalography; electrophysiology; entropy; event related potential; executive function; female; gray matter; human experiment; local field potential; male; middle aged; normal human; Parkinson disease; prefrontal cortex; randomized controlled trial; social behavior; task performance |
Frontiers Media S.A. |
16624548 |
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Article |
Q2 |
1499 |
2279 |
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515 |
Scheibein F., Stowe M.J., Arya S., Morgan N., Shirasaka T., Grandinetti P., Saad N.A., Ghosh A., Vadivel R., Ratta-apha W., Pant S.B., Ransing R., Ramalho R., Bruschi A., Maiti T., HA A.Y., Delic M., Jain S., Peyron E., Siste K., Onoria J., Boujraf S., Dannatt L., Schellekens A., Calvey T. |
57212313904;57217388837;35463222300;57201914207;7005625709;55487378900;57219875515;36833820900;57219874702;35604346900;36114863900;57190296865;56789745200;35298539700;57193679395;57222620752;24476120800;57207211289;57205355338;55644113100;57219876130;57220277366;57200537348;14323807600;55634512900; |
Responding to COVID-19: Emerging Practices in Addiction Medicine in 17 Countries |
2021 |
Frontiers in Psychiatry |
12 |
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634309 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103517973&doi=10.3389%2ffpsyt.2021.634309&partnerID=40&md5=5075a0b04e57dd3c3530b131f94ef9a7 |
School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland; Department of Family Medicine, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; State Drug Dependence Treatment Centre, Institute of Mental Health, Pt Bhagwat Dayal Sharma, University of Health Sciences, Rohtak, India; University of the Witwatersrand, Johannesburg, South Africa; Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Addiction Services (SerD), Department of Territorial Services, ASL Teramo, Teramo, Italy; Department of Psychiatry, Ain Shams University, Cairo, Egypt; Drug Deaddiction and Treatment Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Waikato District Health Board, Waikato, New Zealand; Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand; Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; Department of Psychiatry, BKL Walawalkar Rural Medical College, Ratnagiri, India; Department of Social and Community Health, School of Population Health, The University of Auckland, Auckland, New Zealand; Department of Mental Health, ASL Viterbo, Viterbo, Italy; Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India; Department of Psychological Medicine, University Malaya Centre of Addiction Sciences (UMCAS), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Center for Treatment of Drug Addiction, University Psychiatric Clinic Ljubljana, Ljubljana, Slovenia; Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; AddiPsy, Lyon, France; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, Indonesia; Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda; Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University of Fez, Fes, Morocco; Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Radboud University Medical Centre, Nijmegen, Netherlands; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa |
Scheibein, F., School of Health Sciences, Waterford Institute of Technology, Waterford, Ireland; Stowe, M.J., Department of Family Medicine, School of Medicine, Faculty of Health Sciences, University of Pretoria, Pretoria, South Africa; Arya, S., State Drug Dependence Treatment Centre, Institute of Mental Health, Pt Bhagwat Dayal Sharma, University of Health Sciences, Rohtak, India; Morgan, N., University of the Witwatersrand, Johannesburg, South Africa; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Grandinetti, P., Addiction Services (SerD), Department of Territorial Services, ASL Teramo, Teramo, Italy; Saad, N.A., Department of Psychiatry, Ain Shams University, Cairo, Egypt; Ghosh, A., Drug Deaddiction and Treatment Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Vadivel, R., Waikato District Health Board, Waikato, New Zealand; Ratta-apha, W., Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand; Pant, S.B., Department of Psychiatry and Mental Health, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; Ransing, R., Department of Psychiatry, BKL Walawalkar Rural Medical College, Ratnagiri, India; Ramalho, R., Department of Social and Community Health, School of Population Health, The University of Auckland, Auckland, New Zealand; Bruschi, A., Department of Mental Health, ASL Viterbo, Viterbo, Italy; Maiti, T., Department of Psychiatry, All India Institute of Medical Sciences (AIIMS), New Delhi, India; HA, A.Y., Department of Psychological Medicine, University Malaya Centre of Addiction Sciences (UMCAS), Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Delic, M., Center for Treatment of Drug Addiction, University Psychiatric Clinic Ljubljana, Ljubljana, Slovenia; Jain, S., Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; Peyron, E., AddiPsy, Lyon, France; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, Indonesia; Onoria, J., Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda; Boujraf, S., Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University of Fez, Fes, Morocco; Dannatt, L., Department of Psychiatry and Mental Health, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; Schellekens, A., Radboud University Medical Centre, Nijmegen, Netherlands; Calvey, T., Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa |
[No abstract available] |
addiction medicine; behaviourial addictions; best practice; COVID-19; drug policy; guidelines; substance use |
addiction; addiction medicine; Article; coronavirus disease 2019; health care policy; human; international cooperation; practice guideline; substance use |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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517 |
Anindyajati G., Wiguna T., Murtani B.J., Christian H., Wigantara N.A., Putra A.A., Hanafi E., Minayati K., Ismail R.I., Kaligis F., Savitri A.I., Uiterwaal C.S.P.M., Diatri H. |
57194606169;24367785700;57216652176;57209266195;57218679014;57220161382;56737010600;57218681686;55996895500;36604651700;56401804100;7006033434;36113389500; |
Anxiety and Its Associated Factors During the Initial Phase of the COVID-19 Pandemic in Indonesia |
2021 |
Frontiers in Psychiatry |
12 |
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634585 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102995915&doi=10.3389%2ffpsyt.2021.634585&partnerID=40&md5=b28d0b2bafd0f4413cc6d469ba102a50 |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; The Center for Clinical Epidemiology and Evidence-Based Medicine Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands |
Anindyajati, G., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wiguna, T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Murtani, B.J., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Christian, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wigantara, N.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putra, A.A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Minayati, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ismail, R.I., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kaligis, F., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Savitri, A.I., The Center for Clinical Epidemiology and Evidence-Based Medicine Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Uiterwaal, C.S.P.M., Julius Global Health, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands; Diatri, H., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia—Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus which has not been identified previously in humans. The disease leads to respiratory problems, systemic disorders, and death. To stop the virus transmission, physical distancing was strongly implemented, including working and school from home (WFH & SFH). The limitation altered daily routines and needs advanced to adapt. Many have felt uncomfortable and this could have triggered anxiety symptoms. This study aimed to evaluate the proportion of significant anxiety symptoms and its association with COVID-19-related situations in an Indonesian context during the initial months of the pandemic. Methods: An online community survey was distributed through social media and communication platforms, mainly WhatsApp, targeting people >18 years old in Indonesia. Anxiety symptoms were assessed using Generalized Anxiety Disorder-7 (Indonesian Version). Demographical data and information on social situation related to the COVID-19 pandemic were collected. The proportion of clinically significant anxiety symptoms was calculated and the association with demographic and social factors was assessed using chi square test (χ2) and logistic regression for multivariate analysis. Results: Out of 1215 subjects that completed the survey, 20.2% (n = 245) exhibited significant anxiety symptoms. Several factors, such as age (AOR = 0.933 CI 95% = 0.907–0.96), sex (AOR = 1.612 CI 95% = 1.097–2.369), medical workers (AOR = 0.209 CI 95% = 0.061–0.721), suspected case of COVID-19 (AOR = 1.786 CI 95% = 1.001–3.186), satisfaction level of family support (AOR = 3.052 CI 95% = 1.883–4.946), and satisfaction level of co-workers (AOR = 2.523 CI 95% = 1.395–4.562), were associated with anxiety. Conclusion: One out of five Indonesian people could have suffered from anxiety during the COVID-19 pandemic. The riskiest group being young females, people who had suspected cases of COVID-19, and those with less satisfying social support. Nevertheless, health workers were found to have a lesser risk of developing anxiety. Accessible information and healthcare, social connection, supportive environment, and mental health surveillance are important to prevent bigger psychiatric problems post-pandemic. © Copyright © 2021 Anindyajati, Wiguna, Murtani, Christian, Wigantara, Putra, Hanafi, Minayati, Ismail, Kaligis, Savitri, Uiterwaal and Diatri. |
anxiety; COVID-19 pandemic; Indonesian; mental health surveillance; psychosocial support |
adult; anxiety disorder; Article; controlled study; coronavirus disease 2019; disease association; female; generalized anxiety disorder; high risk population; human; Indonesia; major clinical study; male; mental health; pandemic; patient satisfaction; psychosocial care; risk assessment; risk factor; social support; support group |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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518 |
Apriadi W., Gani H.S., Prayitno P., Ibrahim N., Wijaya S.K. |
57205292872;57202775842;57222538092;56609777400;6506884322; |
Development of multithread acquisition system for high quality EEG signal measurement |
2021 |
Journal of Physics: Conference Series |
1816 |
1 |
012072 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103129496&doi=10.1088%2f1742-6596%2f1816%2f1%2f012072&partnerID=40&md5=8df825ddfea9b100797241af3b95358e |
Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Department of Physiology, Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia |
Apriadi, W., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Gani, H.S., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Prayitno, P., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia; Ibrahim, N., Department of Physiology, Medical Faculty, Universitas Indonesia, Jakarta, 10430, Indonesia; Wijaya, S.K., Department of Physics, FMIPA Universitas Indonesia, Depok, 16424, Indonesia |
This work was concerned on development of the EEG acquisition and EEG signal processing by adding active electrodes and implementing multithread techniques. By using active electrodes, mounting them on the scalp surface would be easier to capture low signals of less than 1µV. The active electrodes were used to reduce noise when transfer signals from the electrode to the acquisition systems which equipped 20 gain. The verification was performed by comparing the active and passive electrodes using NETECH MiniSIM EEG Simulator 330. The advantage of this research was to reduce time delay for EEG signal computation on 32 channels. The acquisition system was based on Raspberry Pi and ADS1299 with multithread signal treatment. Signal filtering was performed into different threads and put all the EEG features into the database. A PC was used to process signal calculation such as processing FFT, signal feature extractions, and signal analysis. These calculations were divided into several functionally independent computations. The signals of each channel were calculated into different threads. The results of this work showed the effectiveness of the multithreaded method for processing large amounts of data (32 channels of 24 bits EEG signal) with low noise levels on the active electrodes. © Published under licence by IOP Publishing Ltd. |
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Electrodes; Acquisition systems; Active electrodes; Eeg acquisitions; EEG signal processing; Large amounts of data; Multithread techniques; Signal treatments; Transfer signals; Biomedical signal processing |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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519 |
Dannatt L., Ransing R., Calvey T., Scheibein F., Saad N.A., Shirasaka T., Ramalho R., Pant S., Vadivel R., Siste K., Stowe M.J., Kalita K.N., Boujraf S., Testa R., Arya S., Morgan N., Grandinetti P. |
57200537348;57190296865;55634512900;57212313904;57219875515;7005625709;56789745200;36114863900;57219874702;55644113100;57217388837;54387032200;57220277366;57222475193;35463222300;57201914207;55487378900; |
The Impact of Stigma on Treatment Services for People With Substance Use Disorders During the COVID-19 Pandemic—Perspectives of NECPAM Members |
2021 |
Frontiers in Psychiatry |
12 |
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634515 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102821643&doi=10.3389%2ffpsyt.2021.634515&partnerID=40&md5=f473eb1aa0aba07997e39ee4f82c800a |
Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Department of Psychiatry, Bhaktshreshtha Kamalakarpant Laxman (BKL) Walalwalkar Rural Medical College, Pune, India; Faculty of Health Sciences, School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South Africa; School of Health Science, Waterford Institute of Technology, Waterford, Ireland; State Drug Dependence Treatment Centre, Ain Shams University, Cairo, Egypt; Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Department of Social and Community Health, School of Population Health, University of Auckland, Auckland, New Zealand; Department of Psychiatry, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Department of Psychiatry, Medical Faculty, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Family Medicine, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa; Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health (LGBRIMH), Tezpur, India; Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; Department of Mental Health, Azienda Sanitaria Locale (ASL), 1 Avezzano-L'Aquila-Sulmona, L'Aquila, Italy; State Drug Dependence Treatment Centre, Institute of Mental Health, Pt. Bhagwat Dayal Sharma (BDS), University of Health Sciences, Rohtak, India; Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Department of Mental Helth, Azienda Sanitaria Locale (ASL) Teramo, Teramo, Italy |
Dannatt, L., Department of Psychiatry and Mental Health, University of Cape Town, Cape Town, South Africa; Ransing, R., Department of Psychiatry, Bhaktshreshtha Kamalakarpant Laxman (BKL) Walalwalkar Rural Medical College, Pune, India; Calvey, T., Faculty of Health Sciences, School of Anatomical Sciences, University of the Witwatersrand, Johannesburg, South Africa; Scheibein, F., School of Health Science, Waterford Institute of Technology, Waterford, Ireland; Saad, N.A., State Drug Dependence Treatment Centre, Ain Shams University, Cairo, Egypt; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Japan; Ramalho, R., Department of Social and Community Health, School of Population Health, University of Auckland, Auckland, New Zealand; Pant, S., Department of Psychiatry, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Vadivel, R.; Siste, K., Department of Psychiatry, Medical Faculty, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Stowe, M.J., Department of Family Medicine, Faculty of Health Sciences, School of Medicine, University of Pretoria, Pretoria, South Africa; Kalita, K.N., Department of Psychiatry, Lokopriya Gopinath Bordoloi Regional Institute of Mental Health (LGBRIMH), Tezpur, India; Boujraf, S., Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco; Testa, R., Department of Mental Health, Azienda Sanitaria Locale (ASL), 1 Avezzano-L'Aquila-Sulmona, L'Aquila, Italy; Arya, S., State Drug Dependence Treatment Centre, Institute of Mental Health, Pt. Bhagwat Dayal Sharma (BDS), University of Health Sciences, Rohtak, India; Morgan, N., Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa; Grandinetti, P., Department of Mental Helth, Azienda Sanitaria Locale (ASL) Teramo, Teramo, Italy |
[No abstract available] |
access to treatment; COVID-19; mental health; pandemic; stigma; substance use disorder |
benzodiazepine; naloxone; opiate agonist; Article; behavioral addiction; coronavirus disease 2019; drug dependence; drug dependence treatment; harm reduction; health care access; health care planning; health care policy; high risk population; homelessness; human; mental health care; pandemic; practice guideline; social discrimination; social distancing; stigma; vulnerable population |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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521 |
Gunardi E.R., Putri R.A., Pasidri Y. |
57192910998;57226166006;57226151144; |
A prospective study of effectivity, expulsion, and acceptability of post-placental iud cu t380a insertion using clamp in a tertiary hospital |
2021 |
Journal of SAFOG |
13 |
2 |
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92 |
96 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110568167&doi=10.5005%2fjp-journals-10006-1884&partnerID=40&md5=fce9faf05542751a7f70c62d508122a7 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Putri, R.A., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynaecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Aim: Intrauterine device (IUD) has a high effectivity of long-term contraception method. Post-placental IUD increases the number of contraception use and decreases the unmet need for contraception. The purposes of this study were to evaluate the effectivity, expulsion, acceptability, and side effects of post-placental IUD insertion using a clamp at Dr. Cipto Mangunkusumo National General Hospital. Materials and methods: This prospective longitudinal observational study was conducted at a tertiary teaching hospital (Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia) from April 2018 to March 2019. Post-placental IUD was inserted using a clamp. We interviewed the patients at 3 months and 6 months after insertion to evaluate the outcome. A total of 94 women were included in this study. Results: The effectivity was 100%. The expulsion rate was 2.13, 3.45, and 0% at 6 weeks, 3 months, and 6 months, respectively. The total acceptability rate at 6 weeks, 3 months, and 6 months was 96.81, 93.3, and 90.8%, respectively. Most of the subjects were satisfied with the IUD contraception at 3 months and 6 months. Conclusion: Post-placental IUD insertion using a clamp had good safety, effectivity, acceptance, and satisfaction. This data could be used for family planning counseling in daily practice. Post-placentaI IUD insertion should be routinely offered to all eligible postpartum women undergoing institutional deliveries. © Jaypee Brothers Medical Publishers. |
Acceptability; Effectivity; Expulsion; Insertion using a clamp; Post-placental IUD |
abdominal pain; adult; Article; bleeding; cesarean section; clinical outcome; contraception; controlled study; counseling; dyspareunia; family planning; female; follow up; gestational age; health care facility; human; hysterectomy; intrauterine device expulsion; lactation; longitudinal study; major clinical study; menstrual cycle; menstruation disorder; observational study; patient satisfaction; percutaneous coronary intervention; postpartum hemorrhage; postpartum pain; pregnancy; pregnancy outcome; pulse rate; questionnaire; tablet disintegration time; tertiary care center; unwanted pregnancy; vagina bleeding; vagina discharge (disease); vaginal delivery |
Jaypee Brothers Medical Publishers (P) Ltd |
09748938 |
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Article |
Q4 |
108 |
29032 |
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522 |
Purwati N.H., Rustina Y., Supriyatno B. |
57224632280;55387850300;37068046400; |
Knowledge and healthcare-seeking behavior of family caregivers of children with pneumonia: A qualitative study in an urban community in Indonesia |
2021 |
Belitung Nursing Journal |
7 |
2 |
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107 |
112 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108107503&doi=10.33546%2fbnj.1268&partnerID=40&md5=a367278f4ff9f46d380f198e1e3929ee |
Faculty of Nursing, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia; Faculty of Nursing, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purwati, N.H., Faculty of Nursing, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia; Rustina, Y., Faculty of Nursing, Universitas Indonesia, Jakarta, Indonesia; Supriyatno, B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Childhood pneumonia is the leading cause of death. Family caregivers may have a poor understanding of pneumonia, especially related to prevention and treatment. It is crucial to understand country-specific knowledge and healthcare-seeking behaviors of caregivers of children with pneumonia before planning programmatic responses, particularly in an urban community where the culture-social economic status is diverse. Objective: This study aimed to describe the knowledge and healthcare-seeking behavior of family caregivers of children with pneumonia in Indonesia's urban community. Methods: A descriptive qualitative study was conducted at a public hospital in Jakarta, Indonesia, from 10 December 2019 to 28 January 2020. Ten family caregivers of children with pneumonia were included, and a semi-structured interview was conducted for data collection. The audio recording was transcribed verbatim, and the data were analyzed using content analysis. Results: The emerged data indicated low knowledge of the family caregivers, especially mothers, which considered pneumonia a common cold only, and they failed to understand the risk of its transmission. Using traditional medicines was the first stage of healthcare-seeking behavior. If the symptoms worsened, the caregivers brought their children to the nearest health center. If there was no change in the symptoms, they headed to the hospital. The health center's location, condition, services, and staff attitude were considered factors to choose the services. Conclusion: Living in an urban area does not guarantee the family caregivers have better knowledge and good healthcare-seeking behavior. Therefore, nurses should provide comprehensive education about pneumonia, its symptoms, and treatment management to improve family care and prevent pneumonia-related deaths. Integrated management of children with illness is recommended to help the family caregivers of children with pneumonia receive treatment as quickly as possible. © The Author(s) 2021 |
Caregivers; Common cold; Healthcare-seeking behavior; Indonesia; Knowledge; Mothers; Nursing; Pneumonia |
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Belitung Raya Publisher - Belitung Raya Foundation |
24774073 |
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Article |
#N/A |
#N/A |
#N/A |
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524 |
Purwaningsih E.H., Oertl A., Freisleben S.K.U., Freisleben H.-J. |
57186723500;6508320409;57192904042;7003437337; |
How can immunosuppression after organ transplantation be made more effective and safer? - A review on liposomal formulations with consideration of archaeal tetraetherlipid |
2021 |
Biomedical and Pharmacology Journal |
14 |
1 |
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33 |
52 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104470529&doi=10.13005%2fbpj%2f2097&partnerID=40&md5=d0059a38fb0687012c274dcda3c60c0f |
Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Faculty of Medicine, Goethe-University Frankfurt/Main, Germany; Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia |
Purwaningsih, E.H., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia; Oertl, A., Faculty of Medicine, Goethe-University Frankfurt/Main, Germany, Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany; Freisleben, S.K.U., Asklepios Clinical Hospital and MVZ, Wiesbaden, Germany, Faculty of Natural Sciences, University of Indonesia, Jakarta-Depok, Indonesia; Freisleben, H.-J., Faculty of Medicine, University of Indonesia, Jakarta-Depok, Indonesia, Faculty of Medicine, Goethe-University Frankfurt/Main, Germany |
Immune-suppressive agents such as methylprednisolone and cyclosporine exert tremendous side effects, because of high dosage and long-term application required for immune suppression after organ transplantation. Major side effects of methylprednisolone include bleeding of the gastro-intestinal tract, hypertension, and osteoporosis, whereas cyclosporine is nephrotoxic. Liposomes are phospholipid particles that allow delivery of drugs preferentially to the reticuloendothelial system. They can be prepared from phospholipids, such as lecithin from soybean or egg yolk, other specific or modified lipids or from membrane-spanning tetraether lipid (TEL), which can be extracted and purified from archaeal cell membranes. One advantage in the use of liposomal application is reduced toxicity of many drugs. We report on various liposomal preparations of cyclosporine, methylprednisolone (L-MPL) and its palmitate derivative (L-MPLP). It has been documented that liposomal cyclosporine A (L-CsA), 1.75 mg/kg/ day for seven days has potential for use as an immune-suppressive agent in rats with increased efficacy and decreased nephrotoxicity compared to commercially available forms of intravenous CsA. Liposomal methylprednisolone (L-MPL) 2 mg/kg, intravenously (IV), twice a week shows significantly prolonged cardiac allograft survival in rats and tissue-selective sequestration of the drug in comparison with the same dosage regimen of methylprednisolone in solution, administered daily. We report on organ distribution of L-MPLP in rats after intraperitoneal (IP) administration. Conclusion: Liposomal preparations of immunosuppressants have significantly higher immune-suppressive potential and lower toxicity than non-liposomal preparations. Bipolar TEL can be extracted, fractionated and purified from archaea to form stable liposomes which are extremely resistant, even to gastric fluid. Hence, TEL liposomes allow (besides IV and IP) for oral administration of immunosuppressants after organ transplantation with pharmacological and toxicological advantages over common liposomal phospholipid bilayer preparations. © 2021 Oriental Scientific Publishing Company. All rights reserved. |
Absorption; Allograft; Cyclosporine; Gastrointestinal stability; Immunosuppressant; Liposomes; Methylprednisolone; Oral administration; Organ transplantation; Toxicity |
alamethicin; albumin; cholesterol; coumarin; cyclosporine; dexamethasone; globulin; glucocorticoid; interleukin 1; liposome; lymphokine; methylprednisolone; phosphatidylcholine; phosphatidylglycerol; phospholipid; tumor necrosis factor; affinity chromatography; allograft; archaeon; Article; bioavailability; cytotoxicity; drug release; drug therapy; egg yolk; electron microscopy; encapsulation; fluorescence; gastrointestinal tract; gel filtration chromatography; helper cell; histocompatibility; human; hypertension; immune response; immunological tolerance; immunosuppressive treatment; lipophilicity; liposomal delivery; macrophage; nephrotoxicity; organ transplantation; osteoporosis; phagocytosis; reticuloendothelial system; soybean; stomach juice; T lymphocyte; thin layer chromatography |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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