No records
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591 |
Rahayatri T.H., Pramudito B.C., Soedibyo S. |
57188549965;57221381023;57216931706; |
Vaginal reconstruction using ileum segment and posterior sagittal anorectoplasty in a patient with Mayer–Rokitansky–Küster–Hauser syndrome with anorectal malformations: A case report |
2021 |
International Journal of Surgery Case Reports |
79 |
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76 |
83 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098963856&doi=10.1016%2fj.ijscr.2020.12.085&partnerID=40&md5=c4c60b2bb5126615110a09f813253345 |
Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rahayatri, T.H., Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pramudito, B.C., Faculty of Medicine, Universitas Indonesia, Department of Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Soedibyo, S., Faculty of Medicine, Universitas Indonesia, Department of Pediatric Surgery, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Vaginal agenesis with anorectal malformations is a complex pediatric condition that adversely affects various physiological processes in the body. It may cause disturbances in defecation and urination, abnormalities in the urinary and gastrointestinal tract, dysfunction of the genital and reproductive organs, and sexual function disorders. The complexity in the surgical management of vaginal agenesis includes the selection of a functional reconstruction technique for anal and vaginal formation, timing of the reconstruction, and management of complications in the associated organ system. Herein, we describe a patient with Mayer–Rokitansky–Küster–Hauser syndrome accompanied by a rectovesical fistula. Other abnormalities, such as microcephaly, polydactyly, long urethral abnormalities resembling the male urethra, and complications in the kidney and urinary tract, were observed in the patient. The associated complications included recurrent urinary tract infections, urinary overflow incontinence, vesicoureteric reflux, hydroureter, and left renal hydronephrosis. The patient underwent posterior sagittal anorectoplasty surgery and vaginal reconstruction. The long-term vaginal physiological development of patients with this condition remains unknown. © 2020 |
Anorectal malformation; MRKH syndrome; Vaginal agenesis |
adult; anorectal malformation; Article; case report; clinical article; female; human; hydronephrosis; hydroureter; ileum; intestine surgery; microcephaly; polydactyly; posterior sagittal anorectoplasty; priority journal; rectovesical fistula; recurrent disease; Rokitansky syndrome; urethra malformation; urinary tract infection; urine incontinence; vagina reconstruction; vesicoureteral reflux |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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592 |
Pribadi R.R., Simadibrata M. |
57194732282;23499598400; |
Increased serum amylase and/or lipase in coronavirus disease 2019 (COVID-19) patients: Is it really pancreatic injury? |
2021 |
JGH Open |
5 |
2 |
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190 |
192 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098140408&doi=10.1002%2fjgh3.12436&partnerID=40&md5=14da866c743f8e6c2bdfff73d45cc7a5 |
Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Pribadi, R.R., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Simadibrata, M., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Coronavirus disease 2019 (COVID-19) is a novel disorder caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although it mainly affects the respiratory system, the pancreas could also become the virus' target. The issue regarding pancreatic involvement in COVID-19 has been raised by several researchers. They found increased serum amylase and/or lipase in COVID-19 patients, which suggested pancreatic injury. We aimed to critically review the evidence to provide insights and to answer the very question of the possibility of pancreatic injury. Current evidence shows that increased amylase and/or lipase is not necessarily a pancreatic injury in COVID-19 patients. Those increased enzymes might also be found in other clinical conditions. © 2020 The Authors. JGH Open: An open access journal of gastroenterology and hepatology published by Journal of Gastroenterology and Hepatology Foundation and John Wiley & Sons Australia, Ltd. |
amylases; COVID-19; lipase; pancreas |
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John Wiley and Sons Inc |
23979070 |
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Review |
Q3 |
546 |
9258 |
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593 |
Tedjasukmana D., Triangto K., Radi B. |
57208885305;56153395600;6603494019; |
Aerobic exercise prescription in heart failure patients with cardiac resynchronization therapy |
2021 |
Journal of Arrhythmia |
37 |
1 |
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165 |
172 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097280088&doi=10.1002%2fjoa3.12475&partnerID=40&md5=9c74c529949e818075ba5b96c9268b86 |
Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tedjasukmana, D., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Triangto, K., Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radi, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Exercise for heart failure patients had been shown to be beneficial in improving functional status, and was reviewed to be safe. In cases of advanced heart failure, Cardiac Resynchronization Therapy (CRT) is a promising medical option before being a heart transplant candidate. CRT itself is a biventricular pacing device, which could detect electrical aberrance in the failing heart and provide a suitable response. Studies have shown that exercise has clear benefits toward improving an overall exercise capacity of the patients. Despite its impacts, these randomized clinical trials have varying exercise regime, and until now there has not been a standardized exercise prescription for this group of patients. The nature of CRT as a pacemaker, sometimes with defibrillator, being attached to a heart failure patient, each has its own potential exercise hazards. Therefore, providing detailed exercise prescription in adjusting to the medical condition is very essential in the field of physical medicine and rehabilitation. Being classified as a high-risk patient group, exercise challenges for the complex heart failure with CRT patients will then be discussed in this literature review, with a general aim to provide a safe, effective, and targeted exercise regime. © 2020 The Authors. Journal of Arrhythmia published by John Wiley & Sons Australia, Ltd on behalf of the Japanese Heart Rhythm Society. |
aerobic exercise prescription; cardiac resynchronization therapy; functional capacity; heart failure; rehabilitation |
aerobic exercise; atrial fibrillation; breathing exercise; cardiac resynchronization therapy; cardiopulmonary exercise test; cardiovascular magnetic resonance; congestive heart failure; coronary sinus; dyspnea; echocardiography; electrocardiography; endurance training; estimated glomerular filtration rate; exercise; exercise intensity; functional status; glycemic control; heart failure; heart function; heart left ventricle ejection fraction; heart output; heart rate; heart stroke volume; heart ventricle arrhythmia; heart ventricle fibrillation; heart ventricle tachycardia; high intensity interval training; human; hypertrophic cardiomyopathy; muscle atrophy; muscle strength; myocarditis; noninvasive ventilation; oxygen consumption; oxygen saturation; pH; physical activity; postoperative com |
Wiley-Blackwell |
18804276 |
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Review |
Q3 |
463 |
10757 |
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598 |
Lisnawati Y., Marianna Y., Rohsiswatmo R. |
57196459289;57267984800;55533574600; |
Increased levels of umbilical cord blood interleukin-6 (IL-6) and Serum C-Reactive Protein (CRP) in premature infants of Vitamin D deficient mothers [Peningkatan Kadar Interleukin-6 (IL-6) Darah Tali Pusat dan Serum C-Reactive Protein (CRP) pada Bayi Prematur Dari Ibu dengan Defisiensi Vitamin D] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
1 |
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21 |
25 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115413252&doi=10.32771%2finajog.v9i1.1397&partnerID=40&md5=15a9474083b536a9bdea004cadbfbb69 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Persahabatan Hospital; Department of Pediatric, Faculty of Medicine, Universitas Indonesia Dr., Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Lisnawati, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Persahabatan Hospital; Marianna, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia Persahabatan Hospital; Rohsiswatmo, R., Department of Pediatric, Faculty of Medicine, Universitas Indonesia Dr., Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: Increased levels of inflammatory factors in newborns are often associated with lower maternal vitamin D levels. This study aimed to find out the relationship between maternal and umbilical cord vitamin D serum levels on umbilical cord Interleukin-6 (IL-6) and serum C-Reactive Protein (CRP) levels in premature infants. Methods: The study was an observational analytic, cross-sectional design in mothers who underwent preterm birth at 28-34 weeks' gestation due to premature rupture of membranes (PROM) and their infants at Dr. Cipto Mangunkusumo General Hospital (RSCM), Jakarta and Persahabatan General Hospital, Jakarta, from January 2017 to August 2018. Levels of serum vitamin D of the maternal and umbilical cord, umbilical cord IL-6 and serum CRP in premature infants were recorded. Vitamin D level was divided into deficiency (<10 ng/mL), insufficiency (10-29 ng/mL), and normal (≥30 ng/mL) groups. The relationship of vitamin D levels with IL-6 and CRP was carried out using Kruskal Wallis test. Results: A total of 70 subjects met the research criteria. Umbilical cord IL-6 and serum CRP levels in premature infants of vitamin D deficient mothers were higher (20.31 pg/mL and 0.50 mg/L) compared to insufficient (3.34 pg/mL and 0.45 mg/L) and normal mothers (3.29 pg/mL and 0.30 mg/L), although not statistically significant (IL-6 p = 0.665, CRP p = 0.89). Referring to the umbilical cord blood vitamin D levels, the results were different and not as expected, in which the umbilical cord IL-6 and serum CRP levels of preterm infants in the deficiency (3.76 pg/mL and 0.35 mg/L) and insufficiency (3.37 pg/mL and 0.40 mg/L) groups were lower (IL-6) and not different (CRP) than the normal group (9.41 pg/mL and 0.40 mg/L). Conclusions: There were atendency for an increase in umbbilical cord IL-6 and serum CRP level in premature infants of Vitamin D deficient mother although these were not statistically significant. Based on the levels of vitamin D umbilical cord blood, the CRP levels in the serum of premature infants were not different, while the IL-6 levels in the deficiency and insufficiency group were lower than in the normal group. © Creative Commons Atribuição-Não Comercial 4.0 Internacional |
CRP; IL-6; Maternal Vitamin D; Umbilical cord Vitamin D |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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599 |
Witjaksono J., Witjaksono F., Perdana A.A. |
6508217612;57070455800;57267346600; |
Role of lifestyle modification through dietary changes to endometrial receptivity on infertility women and obesity with polycystic ovary syndrome [Peran Perubahan Gaya Hidup melalui Perubahan Pola Diet terhadap Reseptivitas Endometrium Perempuan Infertil dan Obesitas dengan Sindrom Ovarium Polikistik] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
1 |
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49 |
54 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115407296&doi=10.32771%2finajog.v9i1.1415&partnerID=40&md5=e89d3e78b19a2a91949fb5c93e148d3b |
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Department of Clinical Nutrition, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
Witjaksono, J., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Witjaksono, F., Department of Clinical Nutrition, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia; Perdana, A.A., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital Indonesia, Jakarta, Indonesia |
Objective: To investigate the effect of lifestyle modification on endometrial receptivity of obese women with polycystic ovary syndrome using ultrasonography. Methods: This observational study was conducted at Dr. Cipto Mangunkusumo General Hospital Jakarta from August 2019 to May 2020. A total of 14 subjects were participated in this study. The subjects were advised to get nutrition counseling by nutritionist and then followed up the endometrial profiles for 6 months by ultrasonography. Results: A total 19 subjects were received nutrition counseling by Clinical nutritionist, but then, only 14 subjects were evaluated the endometrial study by Ultrasonography. There were several significant result between before and after treatment some subjects such as calories, body weight, body mass index, waist circumference (p<0.05) and type of the endometrial vascular zone, endometrium volume, and vascular flow index by ultrasonography (p<0.05). In this study, no significant results have been found on the correlation between dietary changes and changes in endometrial receptivity profiles. Conclusions: No significant correlation was observed between changes in anthropometrics and daily calorie intake with changes in endometrial vascular zones. © Indonesian Journal of Obstetrics and Gynecology 2021. |
Endometrial receptivity; Obese; Polycystic ovary syndrome; Ultrasonography |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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600 |
Kusuma F., Matondang S.B., Nuranna L., Purwoto G., Khonsa O., Hyaswicaksono P. |
57192911548;57192085914;55301184300;14720170400;57268401500;57221907604; |
Postradiotherapy outcome on cervical cancer stage IIIB patients with and without paraaortic lymph nodes enlargement [Hasil Pascaradioterapi pada Pasien Kanker Serviks Stadium IIIB dengan dan tanpa Pembesaran Nodus Paraaorta] |
2021 |
Indonesian Journal of Obstetrics and Gynecology |
9 |
1 |
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55 |
58 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115385362&doi=10.32771%2finajog.v9i1.1438&partnerID=40&md5=4fe5c698192ed33c7d6916029327fcbf |
Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Kusuma, F., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Matondang, S.B., Department of Radiology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Nuranna, L., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Purwoto, G., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Khonsa, O., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hyaswicaksono, P., Department of Obstetrics and Gynecology, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Objective: To determine whether there are differences in clinical response after radiotherapy and 1 year survival in patients with advanced cervical cancer with and without enlargement of PALN. Methods: An observational analytic study using a retrospective cohort method was done using consecutive sampling. The subjects of this study were all women with a primary diagnosis of stages IIB to IVB cervical cancer who came to the gynecological oncology clinic of Dr. Cipto Mangunkusumo National General Hospital and underwent MRI examination before undergoing treatment in January 2016 to May 2017. Results: Among 76 subjects studied, there were 4 (5.1%) subjects who had enlarged PALN. There were no significant differences between the enlargement status of PALN and age (p = 0.829), age of first sexual intercourse (p = 0.33), parity (p = 0.642), mass diameter (p = 0.777). Patients with PALN enlargement have 2.13 times risk of having negative radiotherapy outcome (p = 0.02, OR 2.13, CI95% 1.12 - 4.07). There was no difference in 1-year survival between patients with and without enlargement of PALN (median 201 vs. 293, p = 0.072). Conclusions: Patients with PALN enlargement have increased risk of having negative radiotherapy outcome (p < 0.05). There were no differences in 1 year survival between patients with advanced cervical cancer with enlargement PALN. © Indonesian Journal of Obstetrics and Gynecology 2021. |
Cervical cancer; Lymph node enlargement; Paraaortic; Radiotherapy |
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Indonesian Society of Obstetrics and Gynecology |
23386401 |
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Article |
#N/A |
#N/A |
#N/A |
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601 |
Siswanto J.E., Bos A.F., Dijk P.H., Rohsiswatmo R., Irawan G., Sulistijono E., Sianturi P., Wisnumurti D.A., Wilar R., Sauer P.J.J. |
57205060577;36839156800;6701798049;55533574600;57221815645;57218101844;57192896614;57200574807;57201130415;57221818237; |
Multicentre survey of retinopathy of prematurity in Indonesia |
2021 |
BMJ Paediatrics Open |
5 |
1 |
e000761 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100318807&doi=10.1136%2fbmjpo-2020-000761&partnerID=40&md5=0c40a01ee7a27d4289754e988161b732 |
Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia |
Siswanto, J.E., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands, Neonatology, Harapan Kita National Centre for Women and Children's Health, Jakarta, Indonesia; Bos, A.F., Neonatology, University Medical Center Groningen Intensive Care Medicine, Groningen, Netherlands; Dijk, P.H., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands; Rohsiswatmo, R., Pediatric, University of Indonesia Faculty of Medicine, Jakarta, Indonesia; Irawan, G., Pediatric, Dr Kariadi General Hospital Medical Center, Semarang, Central Java, Indonesia; Sulistijono, E., Pediatric, Dr Saiful Anwar General Hospital, Malang, Jawa Timur, Indonesia; Sianturi, P., Pediatric, University of Sumatera Utara Faculty of Medicine, Medan, North Sumatera, Indonesia; Wisnumurti, D.A., Pediatric, University of Riau Faculty of Medicine, Pekanbaru, Riau, Indonesia; Wilar, R., Pediatric, Sam Ratulangi University Faculty of Medicine, Manado, North Sulawesi, Indonesia; Sauer, P.J.J., Neonatology, Universitair Medisch Centrum Groningen, Groningen, Netherlands |
Background: The incidence of retinopathy of prematurity (ROP) is higher in Indonesia than in high-income countries. In order to reduce the incidence of the disease, a protocol on preventing, screening and treating ROP was published in Indonesia in 2010. To assist the practical implementation of the protocol, meetings were held in all Indonesia regions, calling attention to the high incidence of ROP and the methods to reduce it. In addition, national health insurance was introduced in 2014, making ROP screening and treatment accessible to more infants. Objective To evaluate whether the introduction of both the guideline drawing attention to the high incidence of ROP and national health insurance may have influenced the incidence of the disease in Indonesia. Setting Data were collected from 34 hospitals with different levels of care: national referral centres, university-based hospitals, and public and private hospitals. Methods: A survey was administered with questions on admission numbers, mortality rates, ROP incidence, and its stages for 2016-2017 in relation to gestational age and birth weight. Results: We identified 12 115 eligible infants with a gestational age of less than 34 weeks. Mortality was 24% and any stage ROP 6.7%. The mortality in infants aged less than 28 weeks was 67%, the incidence of all-stage ROP 18% and severe ROP 4%. In the group aged 28-32 weeks, the mortality was 24%, all-stage ROP 7% and severe ROP 4%-5%. Both mortality and the incidence of ROP were highest in university-based hospitals. Conclusions: In the 2016-2017 period, the infant mortality rate before 32 weeks of age was higher in Indonesia than in high-income countries, but the incidence of ROP was comparable. This incidence is likely an underestimation due to the high mortality rate. The ROP incidence in 2016-2017 is lower than in surveys conducted before 2015. This decline is likely due to a higher practitioner awareness about ROP and national health insurance implementation in Indonesia. © Author(s) (or their employer(s)) 2021. |
epidemiology; health services research; mortality; neonatology; ophthalmology |
birth weight; controlled study; data collection method; disease severity; female; gestational age; health services research; health survey; high income country; human; incidence; Indonesia; infant; infant mortality; major clinical study; male; mortality rate; multicenter study; national health insurance; patient referral; physician; practice guideline; prematurity; priority journal; private hospital; public hospital; retrolental fibroplasia; Review; teaching hospital; university hospital |
BMJ Publishing Group |
23999772 |
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Review |
Q1 |
821 |
5832 |
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602 |
Yusuf P.A., Hubka P., Tillein J., Vinck M., Kral A. |
57192156597;6506008977;6602884109;35338597200;55668482500; |
Deafness Weakens Interareal Couplings in the Auditory Cortex |
2021 |
Frontiers in Neuroscience |
14 |
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625721 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100543064&doi=10.3389%2ffnins.2020.625721&partnerID=40&md5=a896b3ce6070ccfa904918c9e995ca32 |
Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany; Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Department of Otorhinolaryngology, Goethe University, Frankfurt am Main, Germany; MedEL Company, Innsbruck, Austria; Ernst Strüngmann Institut for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany; Donders Centre for Neuroscience, Radboud University, Department of Neuroinformatics, Nijmegen, Netherlands; Department of Biomedical Sciences, School of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia |
Yusuf, P.A., Department of Medical Physics/Medical Technology Core Cluster IMERI, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Hubka, P., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany; Tillein, J., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany, Department of Otorhinolaryngology, Goethe University, Frankfurt am Main, Germany, MedEL Company, Innsbruck, Austria; Vinck, M., Ernst Strüngmann Institut for Neuroscience in Cooperation with Max Planck Society, Frankfurt, Germany, Donders Centre for Neuroscience, Radboud University, Department of Neuroinformatics, Nijmegen, Netherlands; Kral, A., Institute of AudioNeuroTechnology, Hannover Medical School, Hanover, Germany, Department of Experimental Otology of the ENT Clinics, Hannover Medical School, Hanover, Germany, Department of Biomedical Sciences, School of Medicine and Health Sciences, Macquarie University, Sydney, NSW, Australia |
The function of the cerebral cortex essentially depends on the ability to form functional assemblies across different cortical areas serving different functions. Here we investigated how developmental hearing experience affects functional and effective interareal connectivity in the auditory cortex in an animal model with years-long and complete auditory deprivation (deafness) from birth, the congenitally deaf cat (CDC). Using intracortical multielectrode arrays, neuronal activity of adult hearing controls and CDCs was registered in the primary auditory cortex and the secondary posterior auditory field (PAF). Ongoing activity as well as responses to acoustic stimulation (in adult hearing controls) and electric stimulation applied via cochlear implants (in adult hearing controls and CDCs) were analyzed. As functional connectivity measures pairwise phase consistency and Granger causality were used. While the number of coupled sites was nearly identical between controls and CDCs, a reduced coupling strength between the primary and the higher order field was found in CDCs under auditory stimulation. Such stimulus-related decoupling was particularly pronounced in the alpha band and in top–down direction. Ongoing connectivity did not show such a decoupling. These findings suggest that developmental experience is essential for functional interareal interactions during sensory processing. The outcomes demonstrate that corticocortical couplings, particularly top-down connectivity, are compromised following congenital sensory deprivation. © Copyright © 2021 Yusuf, Hubka, Tillein, Vinck and Kral. |
bottom-up; cochlear implant; congenital deafness; predictive coding; synchronization; top–down |
adult; alpha rhythm; animal experiment; animal model; animal tissue; Article; auditory cortex; auditory stimulation; beta rhythm; cochlea; controlled study; functional connectivity; hearing acuity; hearing impairment; local field potential; nonhuman |
Frontiers Media S.A. |
16624548 |
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Article |
Q2 |
1499 |
2279 |
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604 |
Sandhiutami N.M.D., Arozal W., Louisa M., Rahmat D., Wuyung P.E. |
56692904000;32067462200;41461551400;36673726800;57192889605; |
Curcumin Nanoparticle Enhances the Anticancer Effect of Cisplatin by Inhibiting PI3K/AKT and JAK/STAT3 Pathway in Rat Ovarian Carcinoma Induced by DMBA |
2021 |
Frontiers in Pharmacology |
11 |
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603235 |
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10 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100565118&doi=10.3389%2ffphar.2020.603235&partnerID=40&md5=5b5af16fb791027b3a94b95b0b6da88b |
Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Animal Research Facility, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Sandhiutami, N.M.D., Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Wuyung, P.E., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Animal Research Facility, Indonesian Medical Education and Research Institute, Jakarta, Indonesia |
Cisplatin has been used for decades for the treatment of ovarian cancer. However, despite its potent anticancer effect, cisplatin’s efficacy as a single agent was inadequate in patients with advanced stage. Curcumin has been shown to sensitize cisplatin activity in several cancer models. However, the low bioavailability of curcumin has limited its anticancer potential. Hence, nano-formulation of curcumin was developed to increase its therapeutic efficacy in ovarian cancer. The objective of this study was to investigate the mechanism of curcumin nanoparticles given in combination with cisplatin in rat ovarian carcinoma induced by dimethylbenz(a)anthracene (DMBA). The administration of cisplatin and nanocurcumin resulted in a significant reduction in ovarian tumor volume and weight. Furthermore, there were reduction in expressions of Ki67, TGF-β, PI3K, and Akt phosphorylation. Co-treatment of cisplatin and nanocurcumin also reduced JAK expression, STAT3 phosphorylation, and reduced IL-6 concentrations. Altogether, nanocurcumin, given as a co-treatment with cisplatin has therapeutic potential in ovarian cancer models by inhibiting proliferation through downregulation of PI3K/Akt and JAK/STAT3 signaling pathways. © Copyright © 2021 Sandhiutami, Arozal, Louisa, Rahmat and Wuyung. |
cisplatin; curcumin; interleukin-6; nanoparticles; ovarian carcinoma; TGF-β |
cisplatin; curcumin; dimethylbenz[a]anthracene; interleukin 6; Janus kinase; Ki 67 antigen; nanoparticle; phosphatidylinositol 3 kinase; protein kinase B; STAT3 protein; transforming growth factor beta; animal cell; animal experiment; animal model; animal tissue; antineoplastic activity; Article; biological model; cell proliferation; controlled study; down regulation; drug efficacy; enzyme inhibition; female; JAK-STAT signaling; nonhuman; ovary carcinoma; Pi3K/Akt signaling; protein expression; protein phosphorylation; rat; tumor volume; tumor weight |
Frontiers Media S.A. |
16639812 |
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Article |
Q1 |
1384 |
2619 |
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605 |
Unggul D.B., Abdullah S., Rachman A. |
57221961543;57204563168;57217184320; |
Laterality condition analysis on non-arteritic anterior ischemic optic neuropathy patient in one of the hospital in Jakarta with medical data mining |
2021 |
Journal of Physics: Conference Series |
1725 |
1 |
012096 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100803241&doi=10.1088%2f1742-6596%2f1725%2f1%2f012096&partnerID=40&md5=38c1992b179967890ac62988e4c116ad |
Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Unggul, D.B., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Abdullah, S., Department of Mathematics, Faculty of Mathematics and Natural Sciences (FMIPA), Universitas Indonesia, Depok, 16424, Indonesia; Rachman, A., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Non-arteritic Anterior Ischemic Optic Neuropathy (NAION) is a disease caused by blood shortages in the artery that supplies the optic disc. Risk factors for NAION are hypertension, obesity, diabetes, dislipidemia, smoking, hypercoagulable state, cardiovascular disease, and stroke. NAION can result from unilateral or bilateral conditions. This study will focus on the identification of important factors that could distinguish characteristics between unilateral and bilateral patients. Random forest method is applied to obtain factors that can consistently distinguish characteristic between each laterality condition. Decision trees and the logistic regression method are added to obtain the visualization of the role of each important factors in the form of classification tree and the risk comparison of patients for experiencing a certain laterality condition by using odds ratios. The important factors based on random forest model are onset, fasting blood glucose levels, high density lipoprotein levels, age, two-hour postprandial glucose levels, and low density lipoprotein levels. Based on the odds ratio, advancing age and high density lipoprotein levels will decrease the risk of patients experiencing bilateral condition; on the other hand, the risk of bilateral condition will increase if other important factors are also increased. © 2021 Journal of Physics: Conference Series. |
Decision tree; Laterality; Logistic regression; Random forest |
Blood; Decision trees; Glucose; Lipoproteins; Logistic regression; Medical computing; Random forests; Blood glucose level; Cardio-vascular disease; Classification trees; High density lipoprotein levels; Logistic regression method; Low density lipoproteins; Random forest methods; Random forest modeling; Data mining |
IOP Publishing Ltd |
17426588 |
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Conference Paper |
Q4 |
210 |
18731 |
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