No records
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905 |
Aniwidyaningsih W., Elhidsi M., Sari A., Burhan E. |
25421525900;57203157152;57221412037;36058554600; |
Characteristics and outcomes of endobronchial tuberculosis therapy |
2021 |
Lung India |
38 |
1 |
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101 |
103 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099112158&doi=10.4103%2flungindia.lungindia-132-20&partnerID=40&md5=5591017e20ced501e613a0e37ddc0328 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Aniwidyaningsih, W., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Elhidsi, M., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Sari, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
[No abstract available] |
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ethambutol; isoniazid; pyrazinamide; rifampicin; steroid; adult; airway obstruction; balloon dilatation; bronchoscopy; clinical article; computer assisted tomography; endobronchial tuberculosis; female; human; Letter; lung tuberculosis; main bronchus; male; retrospective study; thorax radiography; treatment response |
Wolters Kluwer Medknow Publications |
09702113 |
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Letter |
Q3 |
457 |
10877 |
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906 |
Utami T.W., Putri H.M.A.R., Hellyanti T. |
57195720528;57221287879;57217993236; |
High Frequency of Malignant Transformations on Ovarian Mature Teratomas at a Single University Hospital, Jakarta, Indonesia (2015–2018) |
2021 |
Journal of Obstetrics and Gynecology of India |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098720629&doi=10.1007%2fs13224-020-01392-8&partnerID=40&md5=007db828cc36d3a44c192cdca5656bab |
Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indonesia Army Hospital, Jakarta, Indonesia; Department of Pathological Anatomy, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Utami, T.W., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putri, H.M.A.R., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Indonesia Army Hospital, Jakarta, Indonesia; Hellyanti, T., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Department of Pathological Anatomy, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
[No abstract available] |
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Springer |
09719202 |
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Article |
Q3 |
313 |
14416 |
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910 |
Novriansyah R., Prabowo I., Laras S. |
57221099996;57221098612;57221107761; |
Non-microsurgical bipedicled reverse sural fasciocutaneous flap with preservation of medial and lateral sural cutaneous nerve: Current surgical management of skin defect after traumatic Achilles tendon rupture – A case report |
2021 |
International Journal of Surgery Case Reports |
78 |
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259 |
264 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098153477&doi=10.1016%2fj.ijscr.2020.12.027&partnerID=40&md5=dfcacbe40a7720f01ffdc937f2618e67 |
Department of Orthopaedics and Traumatology, Kariadi Hospital – Faculty of Medicine Universitas Diponegoro, Semarang, Indonesia; Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Novriansyah, R., Department of Orthopaedics and Traumatology, Kariadi Hospital – Faculty of Medicine Universitas Diponegoro, Semarang, Indonesia; Prabowo, I., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Laras, S., Department of Orthopaedics and Traumatology, Cipto Mangunkusumo General Hospital – Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: The challenging issue that still remains for reverse sural flap is the withstand of the flap against time, the width of coverage area, and the donor site morbidity such as pain after the medial or lateral sural cutaneous nerve harvested. Presentation of case: A 55 years old male was suffered from traumatic Achilles tendon rupture for 3 months and was repaired with Krakow's technique in a medical center in Pemalang, Indonesia. After the surgery, the defect was revealed as another surgery was planned to cover the skin defect. The author had chosen the bipedicled reverse sural fasciocutaneous flap in regular basis which addressed the superiority and viability of the flap, thus the donor site morbidity was also concerned as the preservation of medial and lateral sural cutaneous nerve, which leading to good quality of life as the patient still could feel and sensate his medial and lateral leg. Discussion: The bipedicled reverse sural fasciocutaneous flap was successfully covered the skin defect on post traumatic Achilles tendon reconstruction, with retained medial sural nerve on its place, and the remaining harvested skin area was leave opened without skin graft which healed spontaneously. Conclusion: Bipedicled reverse sural fasciocutaneous flap with retained medial sural nerve offer a good clinical outcome either the viability of the flap and the maintained sensation along the medial and lateral sural cutaneous nerve distribution. © 2020 |
Bipedicled reverse sural fasciocutaneous flap; Medial sural nerve; Traumatic Achilles tendon rupture |
achilles tendon rupture; adult; Article; case report; clinical article; fasciocutaneous flap; human; male; middle aged; pedicled skin flap; priority journal; skin defect; skin nerve; sural nerve; surgical technique; treatment outcome |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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911 |
Kurniawan A., Kodrat E., Gani Y.I. |
57204398223;57191430080;57195936648; |
Effectiveness of granulocyte colony stimulating factor to enhance healing on delayed union fracture model Sprague-Dawley rat |
2021 |
Annals of Medicine and Surgery |
61 |
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54 |
60 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098139356&doi=10.1016%2fj.amsu.2020.12.005&partnerID=40&md5=55751366daec87d69d3f9b7fe9113d43 |
Paediatric Orthopaedic Division, Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Musculoskletal Pathology Division, Departement of Anatomic Phatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kurniawan, A., Paediatric Orthopaedic Division, Department of Orthopaedics and Traumatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Kodrat, E., Musculoskletal Pathology Division, Departement of Anatomic Phatology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gani, Y.I., Orthopaedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Delayed union is a problem that can occur after fracture healing. Many studies were conducted based on the diamond concept approach to solve the problem of delayed union. Granulocyte-colony stimulating factor (G-CSF) is one of the various substances known to have a positive role in healing skeletal tissue or adjuvant regeneration. This study was conducted to see the effect of G-CSF in affecting delayed union fracture healing. Materials and method: The experimental study was conducted by randomized posttest only control group design on 24 experimental animals Sprague-Dawley white rats that had experienced delayed union models. The study compared the treatment group injected with subcutaneous G-CSF with a control group and was divided into four groups (n = 6). Harvest and follow-up histomorphometry and immunohistochemistry were performed in the second week and in the fourth week the histomorphometry analysis consisted of the percentage of immature bone area, cartilage, and fibrous area. The semiquantitative evaluation of immunohistochemistry with the expression of BMP-2 through the immunoreactive score (IRS). Result: In the evaluation of histomorphometry and immunohistochemical parameters, there were significantly more woven bone area (p = 0,015), less fibrosis area (p = 0,002) and higher BMP 2 expression (p = 0,004) in treatment group week four compared to control. . Conclusion: G-CSF was shown to increase the speed of healing in Sprague-Dawley rats on delayed union models evaluated from histomorphometry and immunohistochemical aspects. © 2020 The Author(s) |
BMP-2; Delayed union; Fracture healing; Granulocyte-colony stimulating factor; Histomorphometry; Immunohistochemistry |
bone morphogenetic protein 2; CD146 antigen; granulocyte colony stimulating factor; phenobarbital; animal experiment; animal model; animal tissue; Article; cartilage; comparative study; controlled study; fibrosis; follow up; fracture healing; histopathology; immunohistochemistry; immunoreactivity; male; morphometry; nonhuman; osteoblast; osteocyte; osteotomy; outcome assessment; protein expression; quantitative analysis; rat; surgical wound |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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913 |
Kurniawan A., Sitorus I.P., Loho T., Hutami W.D. |
57204398223;57191052269;55624513300;57219938996; |
A rare case of septic arthritis of the knee caused by Salmonella typhi with preexisting typhoid fever in a healthy, immunocompetent child – A case report |
2021 |
International Journal of Surgery Case Reports |
78 |
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76 |
80 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097465725&doi=10.1016%2fj.ijscr.2020.12.003&partnerID=40&md5=c608b24d71212feafb989d8f6247e661 |
Pediatric Orthopaedic Surgeon, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Department of Orthopaedic and Traumatology, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Department of Clinical Pathology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia |
Kurniawan, A., Pediatric Orthopaedic Surgeon, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Sitorus, I.P., Department of Orthopaedic and Traumatology, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Loho, T., Department of Clinical Pathology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia; Hutami, W.D., Department of Orthopaedic and Traumatology, Department of Orthopaedic & Traumatology, Cipto Mangunkusumo National Central Hospital and Faculty of Medicine, Universitas Indonesia, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta 10430, Indonesia |
Introduction: Septic arthritis is a rapid and progressive infection caused by invasion of bacteria into the synovial joint. Disease of the joint causedby Salmonella spp in healthy children is an unusual event, with an estimated incidence of 0.1 to 0.2% of septic arthritis cases among children. The incidence of knee septic arthritis caused by Salmonella typhi with preexisting typhoid fever is very rare. Method: We reported a case of 2-years old boy with a history of saddle-type fever 2 weeks prior to right knee pain. Typhoid fever was confirmed by immunoassay test. Knee septic arthritis was established from clinical findings, increased CRP level, ultrasonography, and joint aspiration. Culture of the aspirate subsequently grew Salmonella typhi. This case report had been reported in line with SCARE criteria. Result: Arthrotomy and debridement were immediately performed.Intravenous piperacillin tazobactam was given for 6 days and replaced by amoxicillin clavulanic acid after the culture and sensitivity test was available. Patient recovered completely 5 months post surgery and showed excellence result with normal range of knee joint motion. Conclusion: This case report suggests that any episode of joint swelling following preexisting typhoid fever should arise the physician's awareness toward the possibility of septic arthritis and warrant immediate as well as proper management. © 2020 The Authors |
Case report; Salmonella typhi; Septic arthritis; Typhoid fever |
amikacin; amoxicillin plus clavulanic acid; C reactive protein; cefotaxime; ceftazidime; ceftriaxone; chloramphenicol; cotrimoxazole; gentamicin; meropenem; piperacillin plus tazobactam; sultamicillin; tetracycline; antibiotic sensitivity; arthrotomy; Article; bacterial arthritis; bacterial growth; bacterium isolation; case report; child; clinical article; clinical feature; clinical outcome; debridement; fine needle aspiration biopsy; follow up; human; immunoassay; immunocompetence; joint aspiration; joint effusion; knee arthritis; knee pain; limp (gait); male; preschool child; prescription; priority journal; range of motion; Salmonella enterica serovar Typhi; treatment duration; typhoid fever |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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914 |
Andika R., Birowo P., Rasyid N., Atmoko W. |
57200945045;6504153311;56245069300;57193125664; |
Supine PCNL in patient with staghorn renal stone and severe degree kyphosis: A case report |
2021 |
Urology Case Reports |
34 |
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101509 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097421344&doi=10.1016%2fj.eucr.2020.101509&partnerID=40&md5=0f9040a4a723f7b0d51e13ce3bd1fb6e |
Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Andika, R., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Spinal deformity concomitantly with large renal stone has become a challenges for urologist since it needs different approach in performing percutaneous procedures. This case report highlight our success experience in treating a 53-years old female patients with severe degree of kyphosis and staghorn stone using supine PCNL. She underwent right PCNL and right Double-J stent insertion anterograde after stone were released. The duration of surgery was 2 hours and 45 minutes with no intra and post-operative complication reported. Supine position can be safely chosen if prone cannot be placed in complex situation such as staghorn stone in severe kyphosis patients. © 2020 The Authors |
Kyphosis; PCNL; Spinal deformity; Staghorn renal stone |
creatinine; hemoglobin; urea; adult; anemia; Article; backache; bleeding; case report; chronic kidney failure; clinical article; computer assisted tomography; female; flank pain; human; kyphosis; middle aged; percutaneous nephrolithotomy; postoperative complication; priority journal; staghorn stone; urinalysis; urography; urology; visual analog scale |
Elsevier Inc. |
22144420 |
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Article |
Q3 |
245 |
16962 |
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915 |
Arozal W., Louisa M., Rahmat D., Chendrana P., Sandhiutami N.M.D. |
32067462200;41461551400;36673726800;57220117465;56692904000; |
Development, characterization and pharmacokinetic profile of chitosan-sodium tripolyphosphate nanoparticles based drug delivery systems for curcumin |
2021 |
Advanced Pharmaceutical Bulletin |
11 |
1 |
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77 |
85 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096977127&doi=10.34172%2fapb.2021.008&partnerID=40&md5=8dc05f691c7524d3d33c6f2b7b701019 |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Chendrana, P., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Sandhiutami, N.M.D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: This study aimed to provide the method of preparation, characterization of curcumin-loaded chitosan-sodium tripolyphosphate (NaTPP) nanoparticle, and evaluate its pharmacokinetic profiles. Methods: Curcumin-loaded chitosan-NaTPP nanoparticles were synthesized using ionic gelation methods. Curcumin was dissolved using surfactants and cosurfactants. Chitosan polymer was then mixed in the curcumin solution and dripped with NaTPP solution until nanoparticle formation. The mucoadhesive study was evaluated by measuring the fluorescence of curcumin within the prepared nanoparticles. The pharmacokinetic profiles of curcumin particles and nanoparticles were then assessed in rats by administering a single oral dose of 100 mg/kg BW. Blood samples were taken from nine predetermined time points, and curcumin plasma concentrations were then analyzed using UPLC-MS/MS. Results: The particle size of the curcumin nanoparticles obtained were 11.5 nm. Entrapment efficiency (EE) of curcumin nanoparticles were exceeding 99.97%, and drug loading capacity (DLC) was 11.34%. The mucoadhesive properties of the nanoparticles were superior to that of curcumin particles. Pharmacokinetic evaluation in rats revealed that curcumin nanoparticles resulted in an increase of area under the curve (AUC), maximum concentration (Cmax), earlier time to reach maximum concentration (Tmax), and lower clearance (CL). Conclusion: Curcumin-loaded chitosan-NaTPP nanoparticles is an effective formulation to improve curcumin plasma concentrations. Thus, enable its applications for the treatment of various diseases. © 2021 The Author(s). |
Chitosan; Curcumin; Mucoadhesive; Nanoparticles; Pharmacokinetics |
chitosan; cosurfactant; curcumin; nanoparticle; polymer; surfactant; tripolyphosphate; animal experiment; animal tissue; area under the curve; Article; blood sampling; controlled study; drug delivery system; female; fluorescence; gelation; human; maximum concentration; mucoadhesion; nonhuman; particle size; pharmacokinetic parameters; plasma concentration-time curve; rat; tandem mass spectrometry; ultra performance liquid chromatography; zeta potential |
Tabriz University of Medical Sciences |
22285881 |
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Article |
Q1 |
773 |
6281 |
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920 |
Hakim R.L., Wahyudi I., Irdham G.A., Situmorang G.R., Rodjani A. |
57219532152;36341995300;57194729795;57190001213;6504653529; |
Kidney transplantation with vesicostomy in small-bladder capacity neurogenic bladder dysfunction patient: A case report |
2021 |
Urology Case Reports |
34 |
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101464 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093653802&doi=10.1016%2fj.eucr.2020.101464&partnerID=40&md5=0f09bb4561e856acd141c2350b8c7bec |
Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Hakim, R.L., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wahyudi, I., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Irdham, G.A., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Situmorang, G.R., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rodjani, A., Department of Urology, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Spinal cord injury often results in neurogenic bladder condition and eventually lead to an end-stage renal disease requiring kidney transplantation. However, transplantation in abnormal bladder carries special considerations. We report a case of an adult male with end-stage chronic kidney disease and small bladder capacity after having spinal cord injury. The evaluation of videourodynamic showed reduced compliance and detrusor overactivity during filling phase. Kidney transplantation and vesicostomy was performed. Eighteen months follow-up after surgery showed that kidney function could be maintained. The prevention of increasing bladder pressure and UTI should be monitored to prevent the damage of the graft kidney. © 2020 The Author(s) |
Kidney transplantation; Neurogenic bladder; Spinal cord injury; Vesicostomy |
antibiotic agent; creatinine; hemoglobin; urea; accident; adult; allograft; anuria; Article; bladder capacity; bladder dysfunction; case report; catheter removal; clinical article; cystostomy; end stage renal disease; estimated glomerular filtration rate; falling; hemodialysis; human; kidney function; kidney transplantation; male; nuclear magnetic resonance imaging; overactive bladder; spine fracture; urinary tract disease |
Elsevier Inc. |
22144420 |
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Article |
Q3 |
245 |
16962 |
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No records
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559 |
Kesuma Y., Sekartini R., Timan I.S., Kurniawan A., Bardosono S., Firmansyah A., Vandenplas Y. |
57209278648;57224503576;6602793366;6506883360;21933841000;6602915502;57223670656; |
Irritable bowel syndrome in Indonesian adolescents |
2021 |
Jornal de Pediatria |
97 |
2 |
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197 |
203 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85081734309&doi=10.1016%2fj.jped.2020.02.001&partnerID=40&md5=b8d2dcd5c96832dce29f4c05c71dd219 |
Sriwijaya University and Moh Hoesin Hospital, Faculty of Medicine, Department of Pediatrics, Palembang, Indonesia; University of Indonesia and Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Pediatrics, Jakarta, Indonesia; University of Indonesia Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Clinical Pathology, Jakarta, Indonesia; University of Indonesia, Faculty of Medicine, Department of Parasitology, Jakarta, Indonesia; University of Indonesia, Faculty of Medicine, Department of Nutrition, Jakarta, Indonesia; Free University of Brussels, UZ Brussel Hospital, KidZ Health Castle, Brussels, Belgium |
Kesuma, Y., Sriwijaya University and Moh Hoesin Hospital, Faculty of Medicine, Department of Pediatrics, Palembang, Indonesia; Sekartini, R., University of Indonesia and Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Pediatrics, Jakarta, Indonesia; Timan, I.S., University of Indonesia Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Clinical Pathology, Jakarta, Indonesia; Kurniawan, A., University of Indonesia, Faculty of Medicine, Department of Parasitology, Jakarta, Indonesia, University of Indonesia, Faculty of Medicine, Department of Nutrition, Jakarta, Indonesia; Bardosono, S., University of Indonesia, Faculty of Medicine, Department of Nutrition, Jakarta, Indonesia; Firmansyah, A., University of Indonesia and Cipto Mangunkusumo Hospital, Faculty of Medicine, Department of Pediatrics, Jakarta, Indonesia; Vandenplas, Y., Free University of Brussels, UZ Brussel Hospital, KidZ Health Castle, Brussels, Belgium |
Objective: Irritable bowel syndrome is a frequent functional gastrointestinal disorder. The aims of this study were to investigate its epidemiology, focusing on the role of intestinal mucosal integrity and to evaluate the impact on the quality of life. Methods: A community-based survey applying a comparative cross sectional approach was conducted in six high schools in Palembang. Subjects were recruited using multistage random sampling divided in two groups. Rome III criteria were used to establish a diagnosis of IBS in combination with a questionnaire to determine risk factors. Determination of fecal alpha-1-antitrypsin and calprotectin levels was performed to determine impaired intestinal mucosal integrity. A questionnaire was used to evaluate how quality of life was affected by irritable bowel syndrome. Results: The survey was performed in 454 14−18 years old adolescents, of whom 30.2% fulfilled the Rome III criteria for IBS, with the following subtypes: 36.5% diarrhea, 18.9% constipation, 21.9% mixed, and 22.6% unclassified. Major risk factors were female gender, bullying, age 14–16 years, history of constipation and diarrhea, eating nuts, and drinking coffee, tea, and soft drinks. There was a significant association with intestinal inflammation (p = 0.013). A significantly impaired quality of life was found (p = 0.001). Conclusions: The prevalence of irritable bowel syndrome in adolescents was high, with bullying, female gender, age 14–16 years, constipation and diarrhea, and dietary consumption of soft drinks, coffee, and tea as risk factors. A significant association with intestinal inflammation was found. © 2020 Sociedade Brasileira de Pediatria |
Adolescent; Intestinal integrity; Irritable bowel syndrome; Quality of life |
alpha 1 antitrypsin; calgranulin; adolescent; adult; age; Article; avoidance behavior; body image; bullying; clinical evaluation; coffee consumption; comparative study; constipation; controlled study; cross-sectional study; data analysis software; diarrhea; digestive system disease assessment; disease association; dysphoria; enteritis; feces level; female; gender; high school; human; human activities; human relation; Indonesia; Indonesian; intestine mucosa; Irritable Bowel Syndrome Quality of Life questionnaire; irritable colon; major clinical study; male; nut; patient worry; pediatric patient; prevalence; quality of life; quality of life assessment; risk factor; Rome III criteria; sexual behavior; social behavior; soft drink; tea consumption; constipation; irritable colon; questionnaire; |
Elsevier Editora Ltda |
00217557 |
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32156535 |
Article |
Q2 |
645 |
7804 |
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