No records
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670 |
Mustika R., Yo E.C., Faruqi M., Zhuhra R.T. |
57220273147;57213188908;57339401900;57220591134; |
Evaluating the relationship between online learning environment and medical students’ wellbeing during covid-19 pandemic |
2021 |
Malaysian Journal of Medical Sciences |
28 |
5 |
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108 |
117 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119154731&doi=10.21315%2fmjms2021.28.5.11&partnerID=40&md5=d5595e080d252a1b132526ffc8da06b5 |
Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Mustika, R., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yo, E.C., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Faruqi, M., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Zhuhra, R.T., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The coronavirus disease 2019 (COVID-19) pandemic has been found to negatively affect medical students’ wellbeing. This finding may be related to how medical education is being conducted at present, with online learning replacing face-to-face teaching in many countries. This cross-sectional study aims to assess how the online learning environment is connected to medical students’ wellbeing. Methods: A self-administered online questionnaire was distributed to undergraduate medical students at Universitas Indonesia. The study was conducted from September 2020 to February 2021. The questionnaire included a modified version of the Online Learning Environment Scale (OLES) and the Positive Emotion, Engagement, Relationships, Meaning and Accomplishment (PERMA) profiler. The OLES was used to evaluate students’ perceptions of the online learning environment, whereas the PERMA Profiler was used to evaluate students’ wellbeing. We validated the questionnaire before distribution. The content validity index was 1.0, with internal consistency coefficients of 0.87 and 0.89, respectively. Regression analyses were performed to evaluate the relationship between OLES and PERMA scores. Results: The questionnaire was completed by 274 undergraduate medical students. Students reported moderate to high degrees of positive perception towards online learning, high levels of positive emotions and moderate levels of negative emotions. Statistically significant differences were found across groups based on students’ gender, year of study and academic programme. Almost all aspects of the online learning environment were significantly predictive of students’ wellbeing, with personal relevance and evaluation and assessment being the two most important predictors (R2 = 0.201; P < 0.001). Conclusion: Medical students generally enjoyed online learning, although some challenges were presented. The online learning environment was positively associated with students’ wellbeing; however, some students expressed negative emotions including loneliness, anxiety, anger and sadness. © 2021, Penerbit Universiti Sains Malaysia. All rights reserved. |
COVID-19; Medical students; Online learning environment; Wellbeing |
adult; anger; anxiety; Article; behavioral synchrony; coronavirus disease 2019; cross-sectional study; demography; e-learning; emotion; female; health equity; human; human experiment; learning; learning environment; loneliness; male; medical education; medical student; normal human; pandemic; patient engagement; psychological well-being; questionnaire; sadness; social interaction; undergraduate student; validation study; wellbeing |
Penerbit Universiti Sains Malaysia |
1394195X |
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Article |
Q3 |
394 |
12287 |
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717 |
Kadharusman M.M., Antarianto R.D., Hardiany N.S. |
57222724597;57190862806;57192910605; |
A review of the impact of calorie restriction on stem cell potency |
2021 |
Malaysian Journal of Medical Sciences |
28 |
4 |
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5 |
13 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114744628&doi=10.21315%2fmjms2021.28.4.2&partnerID=40&md5=f082ca9d61a167cf3fec646a0e6012b7 |
Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kadharusman, M.M., Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Calorie restriction (CR) prolongs lifespan in various species and also minimises pathologies caused by aging. One of the characteristics seen in age-related pathologies is stem cell exhaustion. Here, we review the various impacts of CR on mammalian health mediated through stem cell potency in various tissues. This study comprised of a literature search through NCBI, Science Direct, Google Scholar and PubMed, focusing on the impact of CR on pluripotency. In the skeletal muscle, CR acts as an anti-inflammatory agent and increases the presence of satellite cells endogenously to improve regeneration, thus causing a metabolic shift to oxidation to meet oxygen demand. In the intestinal epithelium, CR suppresses the mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells to shift the stem cell equilibrium towards self-renewal at the cost of differentiation. In haematopoiesis, CR prevents deterioration or maintains the function of haematopoietic stem cells (HSCs) depending on the genetic variation of the mice. In skin and hair follicles, CR increases the thickness of the epidermis and hair growth and improves hair retention through stem cells. CR mediates the proliferation and self-renewal of stem cells in various tissues, thus increasing its regenerative ability. © Penerbit Universiti Sains Malaysia, 2021. |
Calorie restriction; Pluripotency; Stem cell |
apoptosis; caloric restriction; cell differentiation; cell proliferation; deterioration; epidermis; fluorescence activated cell sorting; gene expression; genetic variation; hair follicle; hematopoietic stem cell; insulin sensitivity; intestine epithelium; microenvironment; nonhuman; oxidative phosphorylation; oxidative stress; oxygen consumption; physical activity; regenerative ability; Review; signal transduction; skeletal muscle; stem cell; thermal conductivity; upregulation |
Penerbit Universiti Sains Malaysia |
1394195X |
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Review |
Q3 |
394 |
12287 |
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807 |
Jusman S.W.A., Azzizah I.N., Sadikin M., Hardiany N.S. |
36518792100;57223677370;57205093115;57192910605; |
Is the mitochondrial function of keloid fibroblasts affected by cytoglobin? |
2021 |
Malaysian Journal of Medical Sciences |
28 |
2 |
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39 |
47 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106010069&doi=10.21315%2fmjms2021.28.2.4&partnerID=40&md5=8c4df0a7d2cdcd87611b189bf2440f21 |
Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine Universitas Indonesia, Indonesia; Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Jusman, S.W.A., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Azzizah, I.N., Faculty of Medicine Universitas Indonesia, Indonesia; Sadikin, M., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: A keloid is a benign skin tumour characterised by excessive proliferation of fibroblasts, a process that requires a sufficient amount of energy. The energy needs are associated with adequate oxygen (O2) flow and well-functioning mitochondria. It is known that cytoglobin (CYGB) has a function in O2 distribution. The aim of the present study was to explore whether the inhibition of CYGB expression caused impaired mitochondrial function of keloid fibroblasts. Methods: An in vitro study was conducted on a keloid fibroblast derived from our previous study. The study was carried out in the laboratory of the Biochemistry & Molecular Biology Department, Faculty of Medicine, Universitas Indonesia (FMUI), from July to December 2018. CYGB expression was inhibited by small interfering ribonucleic acid (siRNA) and CYGB. Analysis of mitochondrial function was observed through peroxisome proliferator-activated receptor gamma coactivator-1α (PGC-1α), a mitochondrial biogenesis marker and the activity of the succinate dehydrogenase (SDH) enzyme in mitochondria. Results: The CYGB gene and protein were downregulated after treatment with CYGB siRNA. Inhibition of CYGB expression with siRNA also tended to decrease the levels of PGC-1α messenger ribonucleic acid (mRNA) and protein, as well as SDH enzyme activity. Conclusion: Inhibition of CYGB expression with siRNA tended to decrease mitochondrial biogenesis and function. This may be useful for understanding the excessive proliferation of fibroblasts in keloids and for development of treatment for keloids. © Penerbit Universiti Sains Malaysia, 2021. |
CYGB siRNA; Keloid fibroblasts; PGC-1α; SDH enzyme activity |
cytoglobin; oxygen; peroxisome proliferator activated receptor gamma coactivator 1alpha; small interfering RNA; succinate dehydrogenase; Article; cell function; cell proliferation; colorimetry; controlled study; down regulation; enzyme activity; enzyme linked immunosorbent assay; fibroblast; gene expression; genetic transfection; human; human cell; in vitro study; keloid; mitochondrial biogenesis; mitochondrial genetics; mRNA expression level; protein expression; protein isolation; real time polymerase chain reaction; reverse transcription; RNA isolation |
Penerbit Universiti Sains Malaysia |
1394195X |
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Article |
Q3 |
394 |
12287 |
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892 |
Dwinata M., Putera D.D., Hasan I., Raharjo M. |
57209231012;57210288025;12776850800;57212400550; |
SGLT2 inhibitors for improving hepatic fibrosis and steatosis in non-alcoholic fatty liver disease complicated with type 2 diabetes mellitus: a systematic review |
2021 |
Clinical and Experimental Hepatology |
6 |
4 |
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339 |
346 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099931230&doi=10.5114%2fceh.2020.102173&partnerID=40&md5=628a477d8f6d02f9de989db2ce816c8c |
Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Dwinata, M., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Putera, D.D., Faculty of Medicine, Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Hasan, I., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Raharjo, M., Hepatobiliary Division, Department of Internal Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Aim of the study: To evaluate the efficacy of sodium/glucose cotransporter-2 inhibitors (SGLT2i) in improving hepatic fibrosis and steatosis of non-alcoholic fatty liver disease (NAFLD) patients with type 2 diabetes mellitus (T2DM). Material and methods: We searched CENTRAL, MEDLINE, and EMBASE and included any clinical trials involving patients with NAFLD and T2DM aged ≥ 18 years comparing efficacy of SGLT2i and other antidiabetic drugs in improving fibrosis and steatosis, irrespective of publication status, year of publication, and language. Results: Five clinical trials were included. One study reported significant improvements in the controlled attenuation parameter 314.6 ±61.0 dB/m to 290.3 ±72.7 dB/m (p = 0.04) in the SGLT2i group measured by transient elastography. In patients with significant fibrosis, dapagliflozin treatment significantly decreased the liver stiffness measurement from 14.7 ±5.7 kPa at baseline to 11.0 ±7.3 kPa after 24 weeks (p = 0.02). One study reported a significant decrease in liver fat content 16.2% to 11.3% (p < 0.001) in the SGLT2i group compared to the control (p < 0.001). Three studies reported significant improvement in the liver-to-spleen ratio in the SGLT2i group after treatment 0.96 (0.86-1.07) to 1.07 (0.98-1.14), p < 0.01, 0.80 ±0.24 to 1.00 ±0.18, p < 0.001, and 0.91 (0.64-1.04) to 1.03 (0.80-1.20), p < 0.001 respectively. All studies reported a significant decrease in alanine aminotransferase with SGLT2i. Conclusions: SGLT2i is associated with positive effects on hepatic steatosis measured by non-invasive modalities. Further studies are needed to confirm the impact of SGLT2i on hepatic fibrosis and steatosis. © 2020 Termedia Publishing House Ltd.. All rights reserved. |
Diabetes mellitus; Fibrosis; NAFLD; SGLT2 inhibitor; Steatosis |
alanine aminotransferase; dapagliflozin; empagliflozin; ipragliflozin; luseogliflozin; metformin; pioglitazone; sodium glucose cotransporter 2 inhibitor; adult; aged; alanine aminotransferase blood level; Article; comparative effectiveness; controlled study; diabetic patient; drug efficacy; elastography; female; human; liver fibrosis; liver stiffness; major clinical study; male; middle aged; non insulin dependent diabetes mellitus; nonalcoholic fatty liver; quasi experimental study; randomized controlled trial; systematic review; transient elastography; treatment outcome |
Termedia Publishing House Ltd. |
23921099 |
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Article |
Q4 |
394 |
12273 |
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No records
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680 |
Sandora N., Putra M.A., Nurhayati R.W., Suwarti, Nauli R., Kusuma T.R., Fitria N.A., Ardiansyah, Muttaqin C., Makdinata W., Alwi I. |
57204103434;57215605850;55748436600;57212462722;57212478305;57222897694;57148498800;57223036386;57226442135;57223405655;15055173800; |
Characterisation of the single-cell human cardiomyocytes taken from the excess heart tissue of the right ventricular outlet in congenital heart disease |
2021 |
Cell and Tissue Banking |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118214107&doi=10.1007%2fs10561-021-09970-4&partnerID=40&md5=2c4fad90958206777aa1ef5e9ea1e5ec |
Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia; Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sandora, N., Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Putra, M.A., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Nurhayati, R.W., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Suwarti, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Nauli, R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Kusuma, T.R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Fitria, N.A., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Ardiansyah, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muttaqin, C., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Makdinata, W., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Alwi, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Cardiovascular disease is the second highest cause of death across the globe. Myocardial infarction is one of the heart diseases that cause permanent impairment of the heart wall leads to heart failure. Cellular therapy might give hope to regenerate the damaged myocardium. Single cells isolated from an excess heart tissue obtained from the correction of the right ventricular hypertrophy in patients with Tetralogy of Fallot for future heart study were investigated. Methods: Once resected, the heart tissues were transported at 37 °C, in Dulbecco's Modified Eagle's medium/ DMEM (4.5 g.L−1, antibiotic–antimycotic 3x, PRP10% (v/v)), to reach the lab within 30 min, weighted and grouped into less than 500 mg and more than 1000 mg (n = 4). Each sample was digested with 250 U.mL−1 Collagenase type V and 4U.mL−1 Proteinase XXIV in the MACS™ C-tube (Milltenyi, Germany), then dissociated using the MACS™ Octo Dissociator with Heater (Milltenyi, Germany) for 60 min at 37 °C. Results: All cells isolated were rod-shaped cells; viability was up to 90%. The cell density obtained from the 500 mg group were 4,867 ± 899 cells.mg−1 tissue weight, significantly higher compared to the 1,000 mg group; had 557 ± 490 cells.mg−1 tissue weight (mean of (n = 3) ± 95% C.l). The isolated cells were analyzed using FACs BD Flowcytometer, expressed cTnT + 13.38%, PECAM-1 + /VCAM-1- 32.25%, cKit + 7.85%, ICAM + 85.53%, indicating the cardiomyocyte progenitor cells. Conclusion: Cardiomyocytes taken from the wasted heart tissue might be a candidate of cardiomyocytes source to study interventions to the heart as it contained up to 13.38% cardiomyocytes, and 32.25% of cardiac progenitor cells. Moreover, perhaps when cardiac cell therapy needs autologous cardiomyocytes, less than 500 mg tissue weight can be considered as sufficient. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
Cardiac progenitor cells; Cardiomyocyte isolation; Right ventricular resection; Tetralogy of fallot; Waste heart tissue |
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Springer Science and Business Media B.V. |
13899333 |
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Article |
Q3 |
397 |
12196 |
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729 |
Raharjo S.B., Mustika R., Lydia A., Yanni M., Sulastomo H., Zhuhra R.T., Atmadikoesoemah C.A. |
57017880700;57220273147;8451287200;57216309765;57204924380;57220591134;57212145127; |
Trainees' perceptions and expectations of formal academic mentoring during the COVID-19 pandemic in Indonesian cardiology residency programs |
2021 |
Journal of Educational Evaluation for Health Professions |
18 |
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19 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113295810&doi=10.3352%2fJEEHP.2021.18.19&partnerID=40&md5=7733f412708826aa1df71dcc04d870df |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia |
Raharjo, S.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Mustika, R., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lydia, A., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia, Kidney and Hypertension Division, Department of Internal Medicine, Universitas Indonesia, Jakarta, Indonesia; Yanni, M., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Andalas University, Padang, Indonesia; Sulastomo, H., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Sebelas Maret University, Surakarta, Indonesia; Zhuhra, R.T., Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia; Atmadikoesoemah, C.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: During medical residency programs, physicians develop their professional identities as specialists and encounter high expectations in terms of achieving competencies. The responsibilities of medical trainees include caring for patients, balancing work with personal life, and weathering stress, depression, and burnout. Formal academic mentoring programs strive to ease these burdens. The coronavirus disease 2019 (COVID-19) pandemic has altered the trainee-academic mentor relationship, and solutions are needed to address these challenges. The present study aimed to evaluate the formal academic mentoring process through trainees' perceptions and expectations of formal mentoring programs during COVID-19 in Indonesian cardiology residency programs. Methods: This cross-sectional study used a self-administered online questionnaire to capture trainees' perceptions and expectations regarding academic mentoring programs in 3 cardiology residency programs in Indonesia from October to November 2020. The questionnaire was developed before data collection. Perceptions of the existing mentoring programs were compared with expectations. Results: Responses were gathered from 169 out of 174 residents (response rate, 97.3%). Most trainees reported having direct contact with COVID-19 patients (88.82%). They stated that changes had taken place in the mode and frequency of communication with their academic advisors during the pandemic. Significant differences were found between trainees' perceptions of the existing mentoring programs and their expectations for academic mentoring programs (P<0.001). Conclusion: Despite the challenges of interacting with their academic mentors, trainees still perceived academic mentors as a vital resource. Study programs need to consider trainees' expectations when designing academic mentoring programs. © 2021, Korea Health Personnel Licensing Examination Institute (cc) This is an open-access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Communication; COVID-19; Indonesia; Internship and residency; Mentoring |
cardiology; cross-sectional study; human; Indonesia; medical education; mentor; mentoring; motivation; pandemic; perception; questionnaire; Cardiology; COVID-19; Cross-Sectional Studies; Humans; Indonesia; Internship and Residency; Mentoring; Mentors; Motivation; Pandemics; Perception; SARS-CoV-2; Surveys and Questionnaires |
Korea Health Personnel Licensing Examination Institute |
19755937 |
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34399567 |
Article |
Q2 |
397 |
12204 |
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No records
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264 |
Lesmana C.R.A., Mandasari B.K.D. |
8977683000;57223222627; |
The new era of endoscopic ultrasound in biliary disorders |
2021 |
Clinical Journal of Gastroenterology |
14 |
4 |
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923 |
931 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105339459&doi=10.1007%2fs12328-021-01419-1&partnerID=40&md5=e46386a86669ce1318bf2c07a7eeb843 |
Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia; Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia |
Lesmana, C.R.A., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia, Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia; Mandasari, B.K.D., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia |
Biliary obstruction is one of challenging biliary disorders in gastroenterology field, where this long-standing condition can also lead to portal hypertension and multi-disciplinary teamwork is usually needed to manage this problem. Biliary drainage is the primary management to prevent prolonged cholestasis. Biliary system with its thin-walled and tubular structure sometimes makes the diagnosis and therapeutic not easy to approach. Over the past 3 decades, numerous new and modern diagnostic and therapeutic modalities have been developed to manage the complex biliary problems. It is well known that endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), and surgical procedure are common procedures in managing biliary disorders. However, surgical therapy and ERCP are not always easy to perform due to several contraindications. Because of difficulty in performing these procedures or unavailability of these procedures in the facility, PTBD, as the primary non-surgical procedure of choice, has been popular due to its easy technique. Endoscopic ultrasound (EUS) has evolved significantly not only as a diagnostic tool for identification and staging, but also for interventional approaches, especially in management of biliary malignancy. Recently, EUS-guided biliary drainage (EUS-BD) and EUS-guided gallbladder drainage (EUS-GBD) are developed for managing biliary disorders. Whether EUS can be useful for managing biliary obstruction as a primary procedure is still controversial. Hence, a large number of further studies are required to validate. © 2021, Japanese Society of Gastroenterology. |
Biliary obstruction; Endoscopic ultrasound (EUS); EUS-guided biliary drainage (EUS-BD); EUS-guided gallbladder drainage (EUS-GBD); Portal hypertension |
biliary tract disease; biliary tract drainage; cholestasis; endoscopic retrograde cholangiopancreatography; endoscopic ultrasonography; examination; gallbladder drainage; history of medicine; human; interventional ultrasonography; nonhuman; percutaneous transhepatic drainage; portal hypertension; Review; screening; biliary tract tumor; cholestasis; diagnostic imaging; endoscopic ultrasonography; Biliary Tract Neoplasms; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Drainage; Endosonography; Humans |
Springer Japan |
18657257 |
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33895970 |
Review |
Q3 |
414 |
11779 |
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No records
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374 |
Prasasty V.D., Hutagalung R.A., Gunadi R., Sofia D.Y., Rosmalena R., Yazid F., Sinaga E. |
56019989700;57196436040;57223239895;57223238377;56891769500;57207890516;6503946360; |
Prediction of human-Streptococcus pneumoniae protein-protein interactions using logistic regression |
2021 |
Computational Biology and Chemistry |
92 |
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107492 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105320211&doi=10.1016%2fj.compbiolchem.2021.107492&partnerID=40&md5=5e13061470115aaa99774510455cd385 |
Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Department of Biology, Faculty of Life Sciences, Universitas Surya, Tangerang, Banten 15143, Indonesia; Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Faculty of Biology, Universitas Nasional, Jakarta, 12520, Indonesia |
Prasasty, V.D., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Hutagalung, R.A., Faculty of Biotechnology, Atma Jaya Catholic University of Indonesia, Jakarta, 12930, Indonesia; Gunadi, R., Department of Biology, Faculty of Life Sciences, Universitas Surya, Tangerang, Banten 15143, Indonesia; Sofia, D.Y., Department of Biology, Faculty of Life Sciences, Universitas Surya, Tangerang, Banten 15143, Indonesia; Rosmalena, R., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Sinaga, E., Faculty of Biology, Universitas Nasional, Jakarta, 12520, Indonesia |
Streptococcus pneumoniae is a major cause of mortality in children under five years old. In recent years, the emergence of antibiotic-resistant strains of S. pneumoniae increases the threat level of this pathogen. For that reason, the exploration of S. pneumoniae protein virulence factors should be considered in developing new drugs or vaccines, for instance by the analysis of host-pathogen protein-protein interactions (HP-PPIs). In this research, prediction of protein-protein interactions was performed with a logistic regression model with the number of protein domain occurrences as features. By utilizing HP-PPIs of three different pathogens as training data, the model achieved 57–77 % precision, 64–75 % recall, and 96–98 % specificity. Prediction of human-S. pneumoniae protein-protein interactions using the model yielded 5823 interactions involving thirty S. pneumoniae proteins and 324 human proteins. Pathway enrichment analysis showed that most of the pathways involved in the predicted interactions are immune system pathways. Network topology analysis revealed β-galactosidase (BgaA) as the most central among the S. pneumoniae proteins in the predicted HP-PPI networks, with a degree centrality of 1.0 and a betweenness centrality of 0.451853. Further experimental studies are required to validate the predicted interactions and examine their roles in S. pneumoniae infection. © 2021 Elsevier Ltd |
Host-pathogen protein-protein interactions; Logistic regression; Network centrality; Pathway enrichment; Streptococcus pneumoniae |
Forecasting; Logistic regression; Betweenness centrality; Degree centrality; Logistic Regression modeling; Network topology analysis; Protein-protein interactions; Resistant strains; Streptococcus pneumoniae; Virulence factors; Proteins; protein; protein binding; chemistry; host pathogen interaction; human; statistical model; Streptococcus pneumoniae; Host-Pathogen Interactions; Humans; Logistic Models; Protein Binding; Proteins; Streptococcus pneumoniae |
Elsevier Ltd |
14769271 |
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33964803 |
Article |
Q3 |
416 |
11737 |
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No records
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284 |
Rustamadji P., Takbir M., Wuyung P.E., Kusmardi K., Wiyarta E. |
55321572200;57318063000;57192889605;56966625300;57221521342; |
Correlation between CD 34 and CD 68 expression in placental malaria with maternal anemia |
2021 |
Tropical Parasitology |
11 |
2 |
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92 |
96 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118308075&doi=10.4103%2ftp.TP_108_20&partnerID=40&md5=a57c3187c0926ddc2e00415c87f7f7bb |
Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomical Pathology, Labuha Hospital, North Maluku, South Halmahera, Indonesia |
Rustamadji, P., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Takbir, M., Department of Anatomical Pathology, Labuha Hospital, North Maluku, South Halmahera, Indonesia; Wuyung, P.E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Malaria is the second most life-threatening infectious disease in Indonesia, causing approximately 1-3 million deaths annually. Histopathologic studies assessing CD 68 and CD 34 protein expression in placental malaria and its association with maternal anemia are essential to determine the prognosis of malaria in pregnancy. Materials and Methods: This cross-sectional study was carried out in 2017. Thirty biopsy samples of human placental tissue were obtained from Timika and Sumba, and ten normal biopsy samples were taken from the Pathological Anatomy Department of Cipto Mangunkusumo General Hospital as comparisons. CD 34 and CD 68 protein expressions were determined using immunohistochemistry, and the resulting data were analyzed using SPSS. Results: Average hemoglobin (Hb) level was 9.5 mg/dL, 11.5 mg/dL, and 9.9 mg/dL in acute infection, chronic infection, and latent infection, respectively. A positive correlation was found between CD 68 protein expression and maternal Hb level. No correlation was found between CD34 expression and maternal anemia. Conclusions: CD 68 expression in placental tissue biopsy from Timika and Sumba residents with placental malaria was shown to be positively correlated with maternal anemia. Immunohistochemical examination of CD 68 may play a role in the early diagnosis of malaria. © 2021 Tropical Parasitology | Published by Wolters Kluwer - Medknow. |
CD 34; CD 68; Maternal anemia; Placental malaria |
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Wolters Kluwer Medknow Publications |
22295070 |
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Article |
Q3 |
418 |
11707 |
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