No records
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651 |
Sudarma V., Hegar B., Hidayat A., Agustina R. |
55257657600;6506273944;7006069132;57214141404; |
Human Milk Oligosaccharides as a Missing Piece in Combating Nutritional Issues during Exclusive Breastfeeding |
2021 |
Pediatric Gastroenterology, Hepatology and Nutrition |
24 |
6 |
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501 |
509 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121005273&doi=10.5223%2fpghn.2021.24.6.501&partnerID=40&md5=55bd98613f1bc0613d5d9ff96f327b95 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Public Health, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Human Nutrition Research Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sudarma, V., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Hegar, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hidayat, A., Department of Public Health, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Extensive studies have shown that breast milk is the best source of nutrition for infants, especially during the first six months, because it fulfills almost all of their nutritional needs. Among the many functional building blocks in breast milk, human milk oligosaccharides (HMOs) have been receiving more attention recently. Furthermore, it is the third most common group of compounds in human milk, and studies have demonstrated the health benefits it provides for infants, including improved nutritional status. HMOs were previously known as the ‘bifidus factor' due to their ‘bifidogenic' or prebiotic effects, which enabled the nourishment of the gastrointestinal microbiota. Healthy gastrointestinal microbiota are intestinal health substrates that increase nutrient absorption and reduce the incidence of diarrhea. In addition, HMOs, directly and indirectly, protect infants against infections and strengthen their immune system, leading to a positive energy balance and promoting normal growth. Non-modifiable factors, such as genetics, and modifiable factors (e.g., maternal health, diet, nutritional status, environment) can influence the HMO profile. This review provides an overview of the current understanding of how HMOs can contribute to the prevention and treatment of nutritional issues during exclusive breastfeeding. © 2021. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition. All Rights Reserved. |
Breast feeding; Human milk; Nutritional status; Oligosaccharides |
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Korean Society of Pediartic Gastroenterology, Hepatology and Nutrition |
22348646 |
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Article |
Q3 |
440 |
11229 |
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803 |
Nova R., Nurmaini S., Partan R.U., Putra S.T. |
57210234221;26639610000;57190664693;6603587929; |
Automated image segmentation for cardiac septal defects based on contour region with convolutional neural networks: A preliminary study |
2021 |
Informatics in Medicine Unlocked |
24 |
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100601 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106348104&doi=10.1016%2fj.imu.2021.100601&partnerID=40&md5=37e5f3bcab0ef015f7441efa32757710 |
Department of Child Health, Division of Pediatric Cardiology, Dr. Moh Hoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Intelligent System Research Group, Universitas Sriwijaya, Palembang, 30139, Indonesia; Department of Medicine, Dr. MohHoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Department of Child Health, Division of Pediatric Cardiology, Dr. CiptoMangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Nova, R., Department of Child Health, Division of Pediatric Cardiology, Dr. Moh Hoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Nurmaini, S., Intelligent System Research Group, Universitas Sriwijaya, Palembang, 30139, Indonesia; Partan, R.U., Department of Medicine, Dr. MohHoesin Hospital, Faculty of Medicine, Universitas Sriwijaya, Palembang, 30126, Indonesia; Putra, S.T., Department of Child Health, Division of Pediatric Cardiology, Dr. CiptoMangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Echocardiogram examination is important for diagnosing cardiac septal defects. With the development of AI-based technology, an echocardiogram examination previously performed manually by cardiologists can be done automatically. Automatic segmentation of cardiac septal defects can help a physician to make an initial diagnosis before referring a pediatric cardiologist for further treatment. In previous studies, automatic object segmentation using convolutional neural networks (CNNs) was one of the DL applications that have been developed for cardiac abnormalities. In this study, we propose a CNN-based U-Net architecture to automatically segment the cardiac chamber to detect abnormalities (holes) in the heart septum. In this study, echocardiogram examinations were performed on atrial septal defects (ASDs), ventricular septal defects (VSDs), atrioventricular septal defects (AVSDs), and normal hearts with patients undergoing echocardiogram examination at Moh Hoesin Hospital in Palembang. The results show that even for the relatively small number of datasets, the proposed technique can produce superior performance in the detection of the cardiac septal defects. Using the proposed segmentation model for four classes produces a pixel accuracy of 99.15%, mean intersection over union (IoU) of 94.69%, mean accuracy of 97.73%, sensitivity of 96.02%, and F1 score of 94.88%, respectively. The plots of the loss and accuracy curve show that all the errors were small, with accuracy rates reaching 99.05%, 98.62%, 99.39%, and 98.97% for ASD, VSD, AVSD, and normal heart, respectively. The comparison accuracy of contour prediction for U-Net was 99.01%, while V-Net was 93.70%. This shows that the U-Net has better accuracy than the V-Net model architecture. It can be proven that the architecture of CNNs has been successful in segmenting the cardiac chamber to detect defects in the heart septum and support the work of cardiologists. © 2021 The Authors |
Cardiac septal defect; CNNs; Contour segmentation; Deep learning |
adult; Article; atrioventricular septal defect; child; clinical article; clinical examination; computer assisted diagnosis; controlled study; convolutional neural network; deconvolution; deep learning; diagnostic accuracy; diagnostic test accuracy study; heart atrium septum defect; heart ventricle septum defect; human; image processing; image segmentation; pediatric patient; two dimensional echocardiography |
Elsevier Ltd |
23529148 |
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Article |
Q3 |
440 |
11223 |
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827 |
Haryanto T., Suhartanto H., Arymurthy A.M., Kusmardi K. |
57193869197;16423632300;36815724000;56966625300; |
Conditional sliding windows: An approach for handling data limitation in colorectal histopathology image classification |
2021 |
Informatics in Medicine Unlocked |
23 |
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100565 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104075953&doi=10.1016%2fj.imu.2021.100565&partnerID=40&md5=dceb8084f0a81f31189f09578a878d62 |
Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Haryanto, T., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia, Department of Computer Science, IPB University, Kampus IPB Dramaga, Bogor, 16680, Indonesia; Suhartanto, H., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Arymurthy, A.M., Faculty of Computer Science, Universitas Indonesia, Kampus Universitas Indonesia, Depok, 16424, Indonesia; Kusmardi, K., Department of Pathology Anatomy, Faculty of Medicine, Universitas Indonesia, Kampus Universitas Indonesia, Jakarta, Indonesia |
Large amounts of data are required for the training process with a convolutional neural network (CNN) because small datasets with low variation will cause over-fitting, and the model cannot predict new data with high accuracy. Additionally, the non-availability of histopathological medical data presents an issue because without ethical permission, such data cannot be obtained easily. Therefore, this study proposes a conditional sliding window algorithm to obtain sub-sample data on images of histopathology. Two sets of original data were used, one from the Warwick dataset with dimensions of 775 × 522 pixels and the other from the Department of Pathology and Anatomy, Faculty of Medicine Universitas Indonesia. The algorithm used was inspired by the conventional sliding window method, but implemented with added conditions, such as sliding the window algorithm from the left on (x,y) pixel coordinates, thereby moving from left to right, then up to down until the entire image was covered. Consequently, the new image was produced with two dimensions: 200 × 200 and 300 × 300 pixels. However, to avoid loss of information, the 25 and 50 pixels overlap were used. In this study, CNN 7-5-7 was designed and proposed to perform the process. The conditional sliding window algorithm can produce various sub-samples depending on the image and window size. Furthermore, the images produced were used to develop a CNN and were proven to accurately predict benign and malignant tissues compared to the model from the original dataset. Moreover, the sensitivity values of the Warwick public dataset and the one generated in this study are above 0.80, which shows that the proposed CNN architecture is more stable compared to the existing methods such as AlexNet and DenseNet121. This study succeeded in solving the limitations of colorectal histopathological training data by developing a conditional sliding window algorithm. This algorithm can be applied to generate other histopathological data. Moreover, our proposed CNN 7-5-7 is the fastest architecture for training, comparable to state-of-the-art methodologies. Furthermore, the dataset was used to develop the model for colorectal cancer identification and integrated on the web-based application for further implementation. © 2021 The Authors |
Augmentation; Conditional sliding windows; Convolutional neural network; Histopathology |
Article; colorectal cancer; computer language; convolutional neural network; deep learning; diagnostic accuracy; entropy; feature extraction; histopathology; human; image processing; information processing; learning algorithm; sensitivity and specificity |
Elsevier Ltd |
23529148 |
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Article |
Q3 |
440 |
11223 |
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No records
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139 |
Harzif A., Anggraeni T., Syaharutsa D., Hellyanti T. |
57191493435;57192894826;57204145265;57217993236; |
Hysteroscopy role for female genital tuberculosis |
2021 |
Gynecology and Minimally Invasive Therapy |
10 |
4 |
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243 |
246 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119285063&doi=10.4103%2fGMIT.GMIT_151_20&partnerID=40&md5=2dea6cbfe3f4a65bb9bc6b632d3cc573 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Harzif, A., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Anggraeni, T., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syaharutsa, D., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hellyanti, T., Department of Anatomical Pathology, Faculty of Medicine, University of Indonesia, Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Female genital tuberculosis affects the quality of women's lives. One of the symptoms is amenorrhea. In our country, it is still underdiagnosed due to limited resources. Hysteroscopy is known as one of the diagnostic tools for this condition. We performed hysteroscopy and endometrial biopsy in four cases. Hysteroscopy findings show various signs. Histopathological examination showed typical features of tuberculosis in some cases. We also learned that hysteroscopy could evaluate the condition of the endometrium when ongoing and after treatment is accomplished. It is useful for further explanation to the client. Hysteroscopy can be utilized as a diagnostic tool for endometrial sampling, evaluate intracavity condition after treatment, and prognostic tool for future reproductive function. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Amenorrhea; caseous necrosis; genital tuberculosis; hysteroscopy |
tuberculostatic agent; adolescent; adult; Article; case report; caseation; chronic inflammation; clinical article; clinical feature; diagnostic value; echography; endometritis; endometrium; endometrium biopsy; female; female genital tuberculosis; granulomatous inflammation; histopathology; human; human tissue; hysteroscopy; laparotomy; primary amenorrhea; secondary amenorrhea; sister; tuberculous peritonitis; tuberculous spondylitis |
Wolters Kluwer Medknow Publications |
22133070 |
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Article |
Q3 |
441 |
11202 |
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881 |
Harzif A., Hyaswicaksono P., Kurniawan R., Wiweko B. |
57191493435;57221907604;57196055951;43061741400; |
Heterotopic pregnancy: Diagnosis and pitfall in ultrasonography |
2021 |
Gynecology and Minimally Invasive Therapy |
10 |
1 |
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53 |
56 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100537776&doi=10.4103%2fGMIT.GMIT_92_19&partnerID=40&md5=ba933e51def94298b03a38705981ed87 |
Department of Obstetrics and Gynecology, Reproductive Immunology and Endocrinology Division, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, 10340, Indonesia |
Harzif, A., Department of Obstetrics and Gynecology, Reproductive Immunology and Endocrinology Division, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia; Hyaswicaksono, P., Department of Obstetrics and Gynecology, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, 10340, Indonesia; Kurniawan, R., Department of Obstetrics and Gynecology, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jl. Diponegoro No. 71, Jakarta Pusat, 10340, Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Reproductive Immunology and Endocrinology Division, Faculty of Medicine, Dr. Cipto Mangunkusumo General Hospital, Universitas Indonesia, Jakarta, Indonesia |
Heterotopic pregnancy (HP) is the coexistence of extrauterine and intrauterine pregnancies. This case is rare, difficult to diagnose, and threatening if left untreated. Incidental rate is estimated 1 in 30,000 spontaneous pregnancies and higher in assisted reproductive techniques. HP is often missed because of the detection of intrauterine sacs; therefore, comprehensive and systematic ultrasonography (USG) is needed, especially when there is ectopic pregnancy suspicion or when there is free fluid in the pelvis. A 46-year nulligravida with 13-year primary infertility history underwent frozen embryo transfer process with positive beta-human chorionic gonadotropin 2 weeks after the procedure. Clinical pregnancy is expressed by gestational sac findings at 6-week gestation. Two weeks later, she complained of lower right abdominal pain accompanied by spots from the birth canal. USG showed intrauterine pregnancy and sac appropriate to 8-week gestation and adnexal mass accompanied by a ring of fire image. The patient underwent right salpingectomy, recovered well, and continued her pregnancy. In vitro fertilization is the main risk factor for multiple and ectopic pregnancies. Clinical manifestations are similar to pregnancy loss or ectopic pregnancy. Specific risk factor must be acknowledged by the physician prior initial examination to rule out HP. Transvaginal ultrasound is useful in making the diagnosis of HP, especially in early pregnancy. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Heterotopic; laparoscopy; ultrasound |
chorionic gonadotropin beta subunit; progesterone; abdominal pain; adnexa disease; adult; Article; case report; clinical article; ectopic pregnancy; embryo transfer; female; female infertility; first trimester pregnancy; gestational sac; human; in vitro fertilization; middle aged; priority journal; risk factor; salpingectomy; transvaginal echography; uterine adnexa |
Wolters Kluwer Medknow Publications |
22133070 |
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Article |
Q3 |
441 |
11202 |
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No records
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712 |
Rohsiswatmo R., Azharry M., Sari T.T., Bahasoan Y., Wulandari D. |
55533574600;57263156500;36519483600;57263337000;57204024903; |
TLR2 and TLR4 expressions in late-onset neonatal sepsis: Is it a potential novel biomarker? |
2021 |
Journal of Neonatal-Perinatal Medicine |
14 |
3 |
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361 |
367 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115150896&doi=10.3233%2fNPM-200411&partnerID=40&md5=6cf4f414e02f524e32c55a2f9864c09a |
Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rohsiswatmo, R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Azharry, M., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sari, T.T., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bahasoan, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Wulandari, D., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
BACKGROUND: Late-onset neonatal sepsis (LONS) detection is problematic as no single examinations (blood culture, c-reactive protein (CRP), procalcitonin (PCT)) are reliable. Toll-like receptors (TLRs), which detect the presence of pathogen-associated molecular patterns is a promising novel biomarker, but less studied in LONS. This study aimed to determine neutrophils and monocytes TLR2 and TLR4 expression in LONS and their diagnostic value. METHODS: A cross-sectional study conducted in May and June 2017 involving 52 neonates with clinical late-onset (>72 hours of age) sepsis. We examine complete blood count, I/T ratio, CRP, PCT, as well as TLR2 and TLR4 expression to compared with blood culture as the gold standard. We classified cases into proven or unproven sepsis. RESULT: The incidence of LONS was 32.6% in the subjects. The expression of TLR2 was low in LONS, while TLR4 was high. TLR4 neutrophil expression has 88.2% sensitivity, 20% specificity, 34.9% positive predictive value (PPV), 77.8% negative predictive value (NPV), and an AUC of 0.541. TLR4 monocyte expression has 92.1% sensitivity, 11.4% specificity, 34% PPV, 80% NPV, and an AUC of 0.528. The AUC of CRP is increased from 0.608 to 0.843 after combination with TLR4, comparable with CRP + PCT (AUC 0.829). CONCLUSION: The increase in TLR4 expression has good sensitivity but low specificity. TLR4 expression, in combination with CRP, could become a reliable biomarker for the diagnosis of LONS. © 2021-IOS Press. All rights reserved. |
biomarker; c-reactive protein; Late-onset neonatal sepsis; procalcitonin; TLR2; TLR4 |
biological marker; C reactive protein; procalcitonin; toll like receptor 2; toll like receptor 4; biological marker; C reactive protein; TLR2 protein, human; TLR4 protein, human; toll like receptor 2; toll like receptor 4; Acinetobacter baumannii; Article; blood cell count; blood culture; controlled study; cross-sectional study; diagnostic test accuracy study; diagnostic value; female; gold standard; human; Klebsiella pneumoniae; late onset disorder; low birth weight; major clinical study; male; monocyte count; neutrophil count; newborn; newborn sepsis; nonhuman; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; sepsis; Biomarkers; C-Reactive Protein; Cross-Sectional Studies; Humans; Infant, Newborn; Neonatal Sepsis; Sepsis; Toll-Like Rec |
IOS Press BV |
19345798 |
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33164948 |
Article |
Q2 |
444 |
11146 |
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No records
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13 |
Sumapraja K., Hestiantoro A., Liem I.K., Boediono A., Jacoeb T.Z. |
55819683500;8743255100;55802927800;9040094200;57192887569; |
Effect of conditioned medium of umbilical cord-derived mesenchymal stem cells as a culture medium for human granulosa cells: An experimental study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
12 |
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1037 |
1044 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85124898321&doi=10.18502%2fijrm.v19i12.10054&partnerID=40&md5=aa14230b44e7cc7c0f12adca3c46c2b5 |
Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Sumapraja, K., Division of Reproductive Immunoendocrinology, Department of Obstetrics and Gynecology, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hestiantoro, A., Cluster of Human Reproduction, Fertility and Family Planning, the Indonesian Medical Education and Research Institute Universitas Indonesia, Jakarta, Indonesia; Liem, I.K., Department of Anatomy, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Boediono, A., Stem Cell Medical Technology Integrated Service Unit, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Jacoeb, T.Z., Faculty of Veterinary Medicine, Bogor Agricultural University, Bogor, Indonesia |
Background: The umbilical cord-derived mesenchymal stem cells conditioned medium (UC-MSCs-CM) produces secretomes with anti-apoptotic properties, and has the potential to prevent apoptosis of granulosa cells (GC) during controlled ovarian hyperstimulation. Objective: To observe the effect of UC-MSCs-CM on the interaction between pro-and anti-apoptotic proteins and the influence of growth differentiation factor 9 (GDF9) production in GC. Materials and Methods: UC-MSCs-CM was collected from umbilical cord stem cell culture on passage 4. GC from 23 women who underwent in vitro fertilization were cultured and exposed to UC-MSCs-CM for 24 hr. Then RNA of the GC was extracted and the mRNA expression of BCL-2 associated X (BAX), survivin and GDF9 were analysed using quantitative real-time PCR. The spent culture media of the GC were collected for measurement of insulin growth factor 1 using ELISA. Results: The expression of BAX was significantly different after UC-MSCs-CM exposure (4.09E-7 vs. 3.74E-7, p = 0.02). No significant changes occurred in survivin, BAX/survivin ratio, and GDF9 expression after UC-MSCs-CM exposure (p > 0.05). The IGF-1 level of the CM was significantly higher after the CM was used as a culture medium for GC (2.28 vs. 3.07 ± 1.72, p ≤ 0.001). A significant positive correlation was found between survivin and GDF9 (r = 0.966, p ≤ 0.001). Conclusion: IGF-1 produced by UC-MSCs-CM can work in paracrine fashion through the IGF receptor, which can inhibit BAX and maintain GDF9 production. Moreover, under the influence of UC-MSCs-CM, GC are also capable of producing IGF-1, which can impact GC through autocrine processes. © Sumapraja et al. |
BAX; Conditioned medium; GDF9; IGF-1; Survivin |
anti apoptotic protein; baculoviral IAP repeat containing protein 5; complementary DNA; growth differentiation factor 9; Muellerian inhibiting factor; pro apoptotic protein; protein; protein Bax; protein bcl 2; recombinant follitropin; somatomedin; unclassified drug; adult; anesthesia; antiapoptotic activity; antral follicle count; Article; autocrine signaling; cell culture; clinical article; DNA synthesis; enzyme linked immunosorbent assay; female; granulosa cell; human; human cell; in vitro fertilization; information processing; mRNA expression level; oocyte; ovary follicle fluid; real time polymerase chain reaction; RNA extraction; umbilical cord mesenchymal stem cell |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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300 |
Muharam R., Rizal M.S. |
57191492732;57226812403; |
Correlation of calprotectin serum levels with degrees of endometriosis: A cross-sectional study |
2021 |
International Journal of Reproductive BioMedicine |
19 |
7 |
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637 |
644 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112743809&doi=10.18502%2fijrm.v19i7.9474&partnerID=40&md5=34cae0bd86e4721b17270090a5a30ef4 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Muharam, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Rizal, M.S., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Background: Endometriosis is closely associated with delayed diagnosis due to the lack of a definitive and sensitive noninvasive approach. The use of calprotectin in inflammatory process has been demonstrated in various inflammatory diseases. Calprotectin has a significant correlation with high-sensitivity C-reactive protein (hs-CRP) and could be used as an inflammatory marker. No study thus far has evaluated the correlation between calprotectin and endometriosis. Objective: To determine the correlation of calprotectin with the degree of endometriosis in order to help clinicians in establishing better early detection and management. Materials and Methods: In this cross-sectional study, 46 women referred to the Cipto Mangunkusumo, Fatmawati, and Persahabatan Hospitals in Jakarta, Indonesia between July 2017 and April 2018 were enrolled, and their blood serum were taken a day before surgery. Calprotectin serum level was treated using the Phical® ELISA method. After the diagnosis of endometriosis was confirmed through pathological examination, the final diagnosis of endometriosis could be established. The degree of endometriosis was classified according to the revised American Society for Reproductive Medicine (ASRM) classification. Results: The prevalence of minimal, mild, moderate, and severe degrees of endometriosis were 15.2, 39.1, 34.8, and 10.9%, respectively. The median serum calprotectin levels for minimal, mild, moderate, and severe endometriosis were 138.98, 121.49, 124.16, and 122.82 mg/mL, respectively. No correlation was observed between calprotectin and the degrees of endometriosis (r = –0.16, p = 0.278). Conclusion: There is no correlation between calprotectin serum levels and the degrees of endometriosis. © Muharam et al. |
C-reactive protein; Calprotectin; Endometriosis; Inflammation |
biological marker; C reactive protein; calgranulin; adolescent; adult; Article; body mass; correlation coefficient; cross-sectional study; diabetes mellitus; diastolic blood pressure; early diagnosis; endometriosis; enzyme linked immunosorbent assay; female; female infertility; glucose blood level; human; hypertension; major clinical study; protein expression |
Research and Clinical Center for Infertitlity |
24764108 |
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Article |
Q3 |
445 |
11118 |
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No records
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752 |
Pulungan A., Soesanti F., Tridjaja B., Batubara J. |
57192905981;37068080600;6504507193;6506167513; |
Vitamin D insufficiency and its contributing factors in primary school-aged children in Indonesia, a sun-rich country |
2021 |
Annals of Pediatric Endocrinology and Metabolism |
26 |
2 |
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92 |
98 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110706480&doi=10.6065%2fapem.2040132.066&partnerID=40&md5=a96cfde3f3454bb64c938819b9dd6387 |
Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Pulungan, A., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Soesanti, F., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Batubara, J., Department of Child Health, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Purpose: The prevalence of rickets is increasing worldwide in association with an increase in vitamin D deficiency. This study aimed to investigate the vitamin D profile of healthy school-aged children in a sun-rich country and its contributing factors. Methods: This cross-sectional study was conducted in 120 healthy children from 7–12 years of age who live in Jakarta, Indonesia. Their demographic status, sun exposure duration time, and lifestyle were recorded using a structured questionnaire. Serum calcium, phosphate, bone-alkaline phosphatase (B-ALP), and 25-hydroxy vitamin D (25(OH)2D3) levels were measured. The participants were categorized into vitamin D sufficient and non-vitamin D sufficient groups, and we analyzed variables that contributed to the 25(OH)2D3 level. Results: Of the participants, 73 (60.8%) were vitamin D sufficient, 45 (37.5%) were vitamin D insufficient, and 2 (1.7%) were vitamin D deficient. Sex, age, body mass index, Fitzpatrick skin type, daily milk intake, and clothing type were not different between the vitamin D sufficient and non-vitamin D sufficient groups. There were no differences in serum calcium, phosphate, and B-ALP between the 2 groups. Sun exposure time was significantly longer in the vitamin D sufficient group compared with that in the non-vitamin D sufficient group (511.4 min/wk vs. 318.7 min/wk, P=0.004), and this effect remained consistent on multivariate analysis after adjustment for covariates (adjusted odds ratio, 1.002; 95% confidence interval, 1.000–1.003). More participants in the vitamin D sufficient group did not use sunscreen (59 vs. 27, P=0.02), but this finding was inconsistent with our multivariate analysis. Conclusion: Despite year-round sun exposure, approximately 1 in 3 primary school-aged children had insufficient vitamin D level. Sun exposure duration was a major contributing factor. © 2021 Annals of Pediatric Endocrinology & Metabolism. |
25-Hydroxy vitamin D; Rickets; Sun-rich country; Vitamin D deficiency |
25 hydroxyvitamin D; alkaline phosphatase bone isoenzyme; calcifediol; sunscreen; Article; blood analysis; blood sampling; body mass; calcium blood level; child; cross-sectional study; demography; female; human; human cell; human experiment; information processing; major clinical study; male; normal human; nutritional status; phosphate blood level; prevalence; primary school; radioimmunoassay; rickets; school child; skin color; structured questionnaire; sun exposure; vitamin blood level; vitamin D deficiency |
Korean society of pediatric endocrinology |
22871012 |
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Article |
Q2 |
448 |
11054 |
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No records
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406 |
Kristianto H., Waluyo A., Gayatri D., Yunir E., Blow D. |
56121348500;57211433568;57197786176;36520254800;57192313241; |
Neuromuscular taping treatment of diabetic foot: A concept analysis |
2021 |
Clinica Terapeutica |
72 |
3 |
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231 |
235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105531246&doi=10.7417%2fCT.2021.2320&partnerID=40&md5=c143037b6dd7fff4b19b4ba2e89b5b93 |
Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia; Faculty of Nursing, Universitas Indonesia, Indonesia; Faculty of Medicine, Universitas Indonesia, Indonesia; NeuroMuscular Taping Institute, Rome, Italy; Universitas Brawijaya, Indonesia; Universitas, Indonesia |
Kristianto, H., Department of Medical Surgical Nursing, School of Nursing, Faculty of Medicine, Universitas Brawijaya, Indonesia, Faculty of Nursing, Universitas Indonesia, Indonesia, Universitas Brawijaya, Indonesia, Universitas, Indonesia; Waluyo, A., Faculty of Nursing, Universitas Indonesia, Indonesia; Gayatri, D., Faculty of Nursing, Universitas Indonesia, Indonesia; Yunir, E., Faculty of Medicine, Universitas Indonesia, Indonesia; Blow, D., NeuroMuscular Taping Institute, Rome, Italy |
Objective. The definition of neuromuscular taping (NMT) has yet to be clearly analysed as a possible treatment for diabetic foot. Case studies, theoretical analysis and results of existing research may lead to varying perceptions on the definition of NMT and its possible effects on diabetic foot. This article aims to analyse the definition of the NMT concept and furthermore as a basis for future research development on diabetic foot. Methods. The procedure for reference source search include the principal data bases using “neuromuscular taping” and “diabetic foot” keywords for the period of 2010-2019. The concept analysis uses an 8-step approach with the Walker and Avant's method. Results. Analysis of the NMT concept on diabetic foot obtained attributes of elastic tape, skin, pain, edema, injury, sensorimotor, circulation, drainage, relaxation, local, proprioceptive, motion function, strength, contraction, stabilisation, reflex, rehabilitation, care, musculoskeletal, nerve, muscles, tendons, fascia, joints, lymphatic, longitudinal, wrinkles. There were four groups of attributes, namely inflammatory response, vascularity, neuromusculoskeletal function and musculoskeletal system. NMT application benefits for diabetic foot can be attributed to improving walking function, leg position, decreasing pain response, improving body function index, improving leg muscle strength and motor function, increasing range of movement (ROM), maintaining stability of leg joint function, preventing injury, increasing strength and improving position of ankle joints, reducing stiffness, reducing edema and helping wound healing processes. Conclusions. NMT is a decompression application of an elastic tape on the skin on the diabetic foot that has the effect of reducing the inflammatory response, improving vascularity and neuromusculoskeletal function. It aims to improve neuromusculoskeletal and lymphatic system functioning due to the presence of wrinkles, indicating dilation, with local effects on the sensorimotor and proprioceptive senses in conditions of care, rehabilitation and injury. Copyright © Società Editrice Universo (SEU) |
Concept analysis; Diabetic foot; Neuromuscular taping; Operational definition |
cerebral palsy; concept analysis; diabetic foot; edema; fascia; hemiplegia; human; hypertension; inflammation; joint function; leg muscle; lymphatic drainage; motor performance; rehabilitation care; Review; systematic review; tendon; wound healing; wrinkle; athletic tape; diabetes mellitus; diabetic foot; edema; physiology; skeletal muscle; walking; Athletic Tape; Diabetes Mellitus; Diabetic Foot; Edema; Humans; Muscle, Skeletal; Walking |
Societa Editrice Universo |
00099074 |
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33956043 |
Review |
Q3 |
450 |
11019 |
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