No records
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403 |
Fuady A., Nuraini N., Sukandar K.K., Lestari B.W. |
37085331400;24605696400;57216947725;56589945500; |
Targeted vaccine allocation could increase the covid-19 vaccine benefits amidst its lack of availability: A mathematical modeling study in indonesia |
2021 |
Vaccines |
9 |
5 |
462 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105974918&doi=10.3390%2fvaccines9050462&partnerID=40&md5=4a9375c9281f8f4834500172552d5373 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia; Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, 10310, Indonesia, Department of Public Health, Erasmus MC University Medical Center Rotterdam, Rotterdam, 3015 GD, Netherlands; Nuraini, N., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia, Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia; Sukandar, K.K., Department of Mathematics, Institut Teknologi Bandung, Bandung, 40132, Indonesia; Lestari, B.W., Epidemiology Group of COVID-19 Task Force for West Java, Bandung, 40171, Indonesia, Department of Public Health, Faculty of Medicine, Universitas Padjadjaran, Bandung, 40161, Indonesia, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, 6525 GA, Netherlands |
With a limited number of vaccines and healthcare capacity shortages, particularly in low-and middle-income countries, vaccination programs should seek the most efficient strategy to reduce the negative impact of the COVID-19 pandemics. This study aims at assessing several scenarios of delivering the vaccine to people in Indonesia. We develop a model for several scenarios of delivering vaccines: without vaccination, fair distribution, and targeted distribution to five and eight districts with the highest COVID-19 incidence in West Java, one of the most COVID-19-affected regions in Indonesia. We calculate the needs of vaccines and healthcare staff for the program, then simulate the model for the initial 4-month and one-year scenarios. A one-year vaccination program would require 232,000 inoculations per day by 4833 vaccinators. Targeted vaccine allocation based on the burden of COVID-19 cases could benefit the COVID-19 vaccination program by lowering at least 5000 active cases. The benefits would increase by improving the number of vaccines and healthcare staff. Amidst lacking available vaccines, targeted vaccine allocation based on the burden of COVID-19 cases could increase the benefit of the COVID-19 vaccination program but still requires progressive efforts to improve healthcare capacity and vaccine availability for optimal protection for people. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
COVID-19; Low-and middle-income countries; Modeling; Strategy; Vaccine |
SARS-CoV-2 vaccine; Article; coronavirus disease 2019; disease model; disease predisposition; disease transmission; drug bioavailability; drug efficacy; health care need; health care personnel; human; Indonesia; infection rate; mathematical model; mortality; quarantine; reinfection; resource allocation; SIQRD model; vaccination |
MDPI AG |
2076393X |
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Article |
Q1 |
1296 |
2913 |
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404 |
Harbuwono D.S., Sazli B.I., Kurniawan F., Darmowidjojo B., Koesnoe S., Tahapary D.L. |
36056341600;57223390172;57202309006;57210642934;26028015000;55944492500; |
The impact of Ramadan fasting on Fetuin-A level in type 2 diabetes mellitus |
2021 |
Heliyon |
7 |
5 |
e06773 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105783321&doi=10.1016%2fj.heliyon.2021.e06773&partnerID=40&md5=2dd413b4d090b7268ec8e92f9121b6ce |
Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia |
Harbuwono, D.S., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Sazli, B.I., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Kurniawan, F., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Darmowidjojo, B., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia; Koesnoe, S., Division of Allergy and Immunology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Tahapary, D.L., Division of Endocrinology, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia, Metabolic, Cardiovascular and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, Jakarta 10430, Indonesia |
Background/Aims: Ramadan fasting creates changes in lifestyle, causing biochemical alterations that affect glucose metabolism and insulin sensitivity. This study aims to assess the impact of Ramadan fasting on glycemic control and Fetuin-A, a glycoprotein that affects insulin resistance, in patients with type 2 diabetes mellitus (T2DM). Materials and methods: This was a prospective study done among 37 patients with T2DM from Internal Medicine Polyclinic in a hospital in Jakarta, Indonesia. Anthropometric data as well as Hemoglobin A1c (HbA1c), Fasting Blood Glucose (FBG), and Fetuin-A levels of the subjects were measured in three time points: before, during, and after Ramadan fasting. A bivariate analysis was done to see the effect of Ramadan fasting on those parameters. Results: Ramadan fasting reduced Fetuin-A levels [median (minimum–maximum), 5.35 (2.91–7.81) vs. 3.22 (2.35–5.60) mg/dl; p = 0.039] four weeks after the end of Ramadan compared to pre-Ramadan. After two weeks of Ramadan fasting, we found a significant reduction in body weight, BMI, FBG, and HbA1c levels which rebounded to baseline level after Ramadan. Conclusion: Ramadan fasting was associated with a significant decrease in Fetuin-A level post Ramadan. © 2021 The Authors |
Diabetes mellitus; Fetuin-A; Glycoprotein; Insulin resistance; Ramadan fasting |
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Elsevier Ltd |
24058440 |
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Article |
Q1 |
455 |
10919 |
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405 |
Sampurna M.T.A., Rohsiswatmo R., Primadi A., Wandita S., Sulistijono E., Bos A.F., Sauer P.J.J., Hulzebos C.V., Dijk P.H. |
57201733407;55533574600;8422152900;57194904658;57218101844;36839156800;57191375642;6603928053;6701798049; |
Corrigendum to “The knowledge of Indonesian pediatric residents on hyperbilirubinemia management” [Heliyon 7 (4) (2021) e06661](S2405844021007647)(10.1016/j.heliyon.2021.e06661) |
2021 |
Heliyon |
7 |
5 |
e07007 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105737450&doi=10.1016%2fj.heliyon.2021.e07007&partnerID=40&md5=f1c3a5a39332f7f89a1e521e66c2589f |
Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
Sampurna, M.T.A., Neonatology Division, Department of Pediatrics, Airlangga University Teaching Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Rohsiswatmo, R., Neonatology Division, Department of Pediatrics, Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Primadi, A., Department of Pediatrics, Hasan Sadikin Hospital, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Wandita, S., Neonatology Division, Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Sulistijono, E., Department of Pediatrics, Saiful Anwar Hospital, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Bos, A.F., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Sauer, P.J.J., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Hulzebos, C.V., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Dijk, P.H., Department of Pediatrics, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, Netherlands |
In the original published version of this article, the authors provided the incorrect institutional review board number, 1060/KEPK/III/2019. This has now been corrected to 390/Panke.KKE/V/2017. The authors apologise for this mistake. Both the HTML and PDF versions of the article have been updated to correct the error. © 2021 The Author(s) |
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Elsevier Ltd |
24058440 |
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Erratum |
Q1 |
455 |
10919 |
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407 |
Atmoko W., Raharja P.A.R., Birowo P., Ardy A.R., Hamid H., Taher A., Rasyid N. |
57193125664;57201013616;6504153311;57223308079;57223278890;7005269743;56245069300; |
Genetic polymorphisms as prognostic factors for recurrent kidney stones: A systematic review and meta-analysis |
2021 |
PLoS ONE |
16 |
5 May |
e0251235 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105518414&doi=10.1371%2fjournal.pone.0251235&partnerID=40&md5=b6950d085d520fd3088636a18669e525 |
Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Atmoko, W., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Raharja, P.A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Birowo, P., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ardy, A.R., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hamid, H., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Taher, A., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rasyid, N., Department of Urology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Genetic polymorphisms have been suggested as risk factors affecting the occurrence and recurrence of kidney stones, although findings regarding the latter remain inconclusive. We performed this systematic review and meta-analysis to clarify the associations between genetic polymorphisms and recurrent kidney stones. PubMed, SCOPUS, EMBASE, and Cochrane Library databases were searched through May 28th, 2020 to identify eligible studies. The Quality in prognostic studies (QUIPS) tool was used to evaluate bias risk. Allelic frequencies and different inheritance models were assessed. All analyses were performed using Review manager 5.4. A total of 14 studies were included for meta-analysis, assessing urokinase (ApaL1) and vitamin D receptor (VDR) (ApaI, BsmI, FokI, and TaqI) gene polymorphisms. The ApaLI polymorphism demonstrated protective association in the recessive model [odds ratio (OR) 0.45, P < 0.01] albeit higher risk among Caucasians in the heterozygous model (OR 16.03, P < 0.01). The VDR-ApaI polymorphism showed protective association in the dominant model (OR 0.60, P < 0.01). Among Asians, the VDR-FokI polymorphism recessive model showed significant positive association (OR 1.70, P < 0.01) and the VDR-TaqI polymorphism heterozygous model exhibited protective association (OR 0.72, P < 0.01). The VDR-BsmI polymorphism was not significantly associated with recurrent kidney stones in any model. Urokinase-ApaLI (recessive model), VDR-ApaI (dominant model), and VDR-TaqI (heterozygous model) polymorphisms were associated with decreased recurrent kidney stone risk whereas urokinase-ApaLI (heterozygous model) and VDR-FokI polymorphisms were associated with increased risk among Caucasians and Asians, respectively. These findings will assist in identifying individuals at risk of kidney stone recurrence. © 2021 Atmoko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author andsource are credited. |
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urokinase; vitamin D receptor; ApaL1 gene; Asian; Caucasian; dominant inheritance; gene frequency; genetic association; genetic polymorphism; genetic variability; heterozygosity; high risk patient; human; nephrolithiasis; prognosis; protection; recessive inheritance; recurrence risk; Review; risk reduction; systematic review; VDR gene; genetic polymorphism; genetics; meta analysis; nephrolithiasis; prognosis; recurrent disease; Humans; Kidney Calculi; Polymorphism, Genetic; Prognosis; Recurrence |
Public Library of Science |
19326203 |
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33956883 |
Review |
Q1 |
990 |
4434 |
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419 |
Iwai M., Tulafu M., Togo S., Kawaji H., Kadoya K., Namba Y., Jin J., Watanabe J., Okabe T., Hidayat M., Sumiyoshi I., Itoh M., Koyama Y., Ito Y., Orimo A., Takamochi K., Oh S., Suzuki K., Hayashizaki Y., Yoshida K., Takahashi K. |
56357096800;55818028100;9533914900;57196621148;57193562606;55413965500;57221345975;57202019639;57208252941;56435992700;57202003876;57218355452;57202921569;57225926629;56922531400;57070836300;56922435100;57221017119;57216108710;55725231300;57226207751; |
Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression |
2021 |
Molecular Oncology |
15 |
5 |
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1507 |
1527 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103164588&doi=10.1002%2f1878-0261.12937&partnerID=40&md5=b2e053e6ecbd024c8cbcf42081179238 |
Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan; Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan |
Iwai, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Tulafu, M., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Togo, S., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Kawaji, H., Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan, Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Kadoya, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Namba, Y., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Jin, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Watanabe, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Okabe, T., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Hidayat, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Sumiyoshi, I., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Itoh, M., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Koyama, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan, Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Ito, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Orimo, A., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Takamochi, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Oh, S., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Suzuki, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Hayashizaki, Y., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Yoshida, K., Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan; Takahashi, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan |
Cancer-associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of phenotypic changes, CAFs control cancer–stroma interactions through integrin receptor signaling. Here, we isolated CAFs from patients with non-small-cell lung cancer (NSCLC) and examined their gene expression profiles. We identified collagen type XI α1 (COL11A1), integrin α11 (ITGA11), and the ITGA11 major ligand collagen type I α1 (COL1A1) among the 390 genes that were significantly enriched in NSCLC-associated CAFs. Increased ITGA11 expression in cancer stroma was correlated with a poor clinical outcome in patients with NSCLC. Increased expression of fibronectin and collagen type I induced ITGA11 expression in CAFs. The cellular migration of CAFs toward collagen type I and fibronectin was promoted via ERK1/2 signaling, independently of the fibronectin receptor integrin α5β1. Additionally, ERK1/2 signaling induced ITGA11 and COL11A1 expression in cancer stroma. We, therefore, propose that targeting ITGA11 and COL11A1 expressing CAFs to block cancer–stroma interactions may serve as a novel, promising anti-tumor strategy. © 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
cancer; cancer-associated fibroblast; collagen type I; collagen type XI α1; integrin alpha-11; non-small-cell lung cancer; stroma interaction; transforming growth factor beta |
alpha11 integrin; collagen type 1; collagen type 1 alpha1; collagen type 11; collagen type 11 alpha1; fibronectin; fibronectin receptor; integrin; mitogen activated protein kinase 3; retrovirus vector; small interfering RNA; transforming growth factor beta1; unclassified drug; very late activation antigen 5; adult; aged; Article; cancer associated fibroblast; cancer recurrence; cell interaction; cell migration; chemotaxis; clinical article; clinical outcome; controlled study; DNA modification; enzyme linked immunosorbent assay; female; gene expression profiling; human; human cell; human tissue; immunohistochemistry; in vitro study; lung adenocarcinoma; lung fibroblast; lung parenchyma; male; non small cell lung cancer; priority journal; protein expression; protein expression level; protein |
John Wiley and Sons Ltd |
15747891 |
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33682233 |
Article |
Q1 |
2332 |
1019 |
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421 |
Teixeira J.C., Jacobs G.S., Stringer C., Tuke J., Hudjashov G., Purnomo G.A., Sudoyo H., Cox M.P., Tobler R., Turney C.S.M., Cooper A., Helgen K.M. |
56290678400;56504646300;7005875885;20435156700;8937651700;56262110300;6603548824;8699959500;55780763900;7003984281;57225849511;6602538000; |
Widespread Denisovan ancestry in Island Southeast Asia but no evidence of substantial super-archaic hominin admixture |
2021 |
Nature Ecology and Evolution |
5 |
5 |
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616 |
624 |
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8 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102829045&doi=10.1038%2fs41559-021-01408-0&partnerID=40&md5=0f530b00ed05b700fb2df18763c0144f |
Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Complexity Institute, Nanyang Technological University, Singapore, Singapore; Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; South Australian Museum, Adelaide, SA, Australia; BlueSky Genetics, Ashton, SA, Australia; Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Jacobs, G.S., Complexity Institute, Nanyang Technological University, Singapore, Singapore, Department of Archaeology, University of Cambridge, Cambridge, United Kingdom; Stringer, C., Centre for Human Evolution Research, Department of Earth Sciences, Natural History Museum, London, United Kingdom; Tuke, J., School of Mathematical Sciences, The University of Adelaide, Adelaide, SA, Australia; Hudjashov, G., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Cox, M.P., Statistics and Bioinformatics Group, School of Fundamental Sciences, Massey University, Palmerston North, New Zealand; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, The University of Adelaide, Adelaide, SA, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), The University of Adelaide, Adelaide, SA, Australia; Turney, C.S.M., Chronos 14Carbon-Cycle Facility, Earth and Sustainability Science Research Centre, School of Biological, Earth and Environmental Sciences, University of New South Wales, Sydney, NSW, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia; Cooper, A., South Australian Museum, Adelaide, SA, Australia, BlueSky Genetics, Ashton, SA, Australia; Helgen, K.M., ARC Centre of Excellence for Australian Biodiversity and Heritage (CABAH), University of New South Wales, Sydney, NSW, Australia, Australian Museum Research Institute, Australian Museum, Sydney, NSW, Australia |
The hominin fossil record of Island Southeast Asia (ISEA) indicates that at least two endemic ‘super-archaic’ species—Homo luzonensis and H. floresiensis—were present around the time anatomically modern humans arrived in the region >50,000 years ago. Intriguingly, contemporary human populations across ISEA carry distinct genomic traces of ancient interbreeding events with Denisovans—a separate hominin lineage that currently lacks a fossil record in ISEA. To query this apparent disparity between fossil and genetic evidence, we performed a comprehensive search for super-archaic introgression in >400 modern human genomes, including >200 from ISEA. Our results corroborate widespread Denisovan ancestry in ISEA populations, but fail to detect any substantial super-archaic admixture signals compatible with the endemic fossil record of ISEA. We discuss the implications of our findings for the understanding of hominin history in ISEA, including future research directions that might help to unlock more details about the prehistory of the enigmatic Denisovans. © 2021, The Author(s), under exclusive licence to Springer Nature Limited part of Springer Nature. |
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animal; fossil; genetics; hominid; Homo neanderthalensis; human; island (geological); Southeast Asia; Animals; Asia, Southeastern; Fossils; Hominidae; Humans; Islands; Neanderthals |
Nature Research |
2397334X |
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33753899 |
Article |
Q1 |
5822 |
225 |
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426 |
Radfar S.R., De Jong C.A.J., Farhoudian A., Ebrahimi M., Rafei P., Vahidi M., Yunesian M., Kouimtsidis C., Arunogiri S., Massah O., Deylamizadeh A., Brady K.T., Busse A., Potenza M.N., Ekhtiari H., Baldacchino A.M., Abagiu A.O., Abouna F.D.N., Ahmed M.H., Al-ansari B., Mahmmoud Abu Al-khair F., Almaqbali M.H., Ambekar A., Ardabili H.M., Arya S., Lasebikan V.O., Ayasreh M.A., Basu D., Benmebarek Z., Bhad R., Blaise M., Bonnet N., Brasch J., Broers B., Butner J.L., Camilleri M., Campello G., Carra G., Celic I., Chalabianloo F., Chaturvedi A., de Jesús Eduardo Noyola Cherpitel J., Clark K.J., Cyders M.A., de Bernardis E., Derry J.E., Dhagudu N.K., Dolezalova P., Dom G., Dunlop A.J., Elhabiby M.M., Elkholy H., Essien N.F., Farah G.I., Ferri M., Floros G.D., Friedman C., Fuderanan C.H., Gerra G., Ghosh A., Gogia M., Grammatikopoulos I.A., Grandinetti P., Guirguis A., Gutnisky D., Haber P.S., Hassani-Abharian P., Hooshyari Z., Ibrahim I.I.M., Ieong H., Indradewi R.N., Iskandar S., Jain S., James S., Javadi S.M.H., Joe K.H., Jokubonis D., Jovanova A.T., Kamal R.M., Kantchelov A.I., Kathiresan P., Katzman G., Kawale P., Kern A.M., Kessler F.H.P., Kim S., Kimball A.M., Kljucevic Z., Siste K., Lev R., Lee H.K., Lengvenyte A., Lev-ran S., Mabelya G.S., Mahi M.A.E., Maphisa J., Maremmani I., Masferrer L., McCambridge O., McGovern G.G., Min A.K., Moghanibashi-Mansourieh A., Mora-Rios J., Mudalige I.U.K., Mukherjee D., Munira P.M., Myers B., Menon T N J., Narasimha V.L., Ndionuka N., Nejatisafa A., Niaz K., Nizami A.T., Nuijens J.H., Orsolini L., Oum V., Oyemade A.A., Palavra I.R., Pant S.B., Paredes J., Peyron E., Alberto Quirós R., Qurishi R., Rafiq N.U.Z., Rao R.R., Ratta-apha W., Raymond K., Reimer J., Renaldo E., Rezapour T., Robertson J.R., Roncero C., Roub F., Rubenstein E.J., Rupp C.I., Saenz E., Salehi M., Samartzis L., Sarubbo L.B., Segrec N., Shah B., Shen H., Shirasaka T., Shoptaw S., Sintango F.M., Sosa V.A., Subata E., Sztycberg N., Taghizadeh F., Teck J., Tjagvad C., Torrens M., Twala J.M., Vadivel R., Volpicelli J.R., Weijs J., Wintoniw S.M., Wittayanookulluk A., Wojnar M., Yasir S., Yitayih Y., Zhao M., Zonoozi A.K., ISAM-PPIG Global Survey Consortium |
36019651400;55394697400;25631625900;57218203004;57218199674;57203060812;14622058700;6602323007;55912287400;57044778200;57221410258;7101818468;57196510693;7006591634;26632924600;6603786612;55021572500;57221605725;57221411272;56996118200;57223918710;57221411355;35749590300;55658200400;35463222300;8344788700;57221410448;18833291700;57219202850;55789741800;6603894892;15135243700;57189041459;7003868723;56816710600;57221410155;56400851700;7003818736;24176502200;26026739900;54936844000;57221594973;57221410761;6504408224;55604104700;57221409824;57203836122;6603422138;12768470700;57219674374;26767656700;55086535500;57191041815;57221411550;8871569800;12768168000;57221411410;57210375852;55578764500;36833820900;57205763778;27367905800;55487378900;55496109900;57221411047;7004422180;54892046900;36607951600;57216708013;57193806115;57221410095;37004580200;57207211289;57216621884;57207842636;15062725000;57188646762;57221411023;57225330134;24468101500;57023935300;57221410517;55928375400;55031071400;57202970264;57221410531;35420584800;57203155640;55644113100;8913859800;8600274900;57189340754;23019092700;57221410613;57223919852;57200792839;7003948428;6507438528;56527137000;57221410507;57221411329;56059054800;6506077151;57214574855;57197364393;57221410358;7202684194;57202980793;56272241600;57221410263;55666521300;57194102646;12144358600;7004198198;55376767200;57217227990;16234058300;57225265059;36114863900;57221411223;57205355338;57223921125;55735687800;57221410341;57221411320;35604346900;56783754400;56000939600;57221410809;56968163500;57205640157;7003524112;57191926633;57221411128;7006106435;26656074800;56400278400;36633076300;57221409908;24476669600;57219874143;57216762422;7005625709;7003465287;57221409902;57221409982;56616079200;57221410011;55802145800;57212685292;57188537200;57202041764;57221411350;57219874702;57209053124;57221410085;57221410695;55151590700;6701757799;57221410275;57204013732;55185317400;57218205554; |
Reorganization of Substance Use Treatment and Harm Reduction Services During the COVID-19 Pandemic: A Global Survey |
2021 |
Frontiers in Psychiatry |
12 |
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639393 |
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14 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106509698&doi=10.3389%2ffpsyt.2021.639393&partnerID=40&md5=1fea38b85d8c747702486edae8c470b9 |
Department of Neuroscience and Addiction, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran; Integrated Substance Abuse Programs Department, University of California, Los Angeles, Los Angeles, CA, United States; Behavioral Science Institute Radboud University, Nijmegen, Netherlands; Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Materials and Energy Research Center, Tehran, Iran; Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran; School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Surrey and Borders Partnership, NHS Foundation Trust, Leatherhead, United Kingdom; Turning Point, Eastern Health, Box Hill, VIC, Australia; Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; Rebirth Charity Society NGO, Tehran, Iran; Medical University of South Carolina, Charleston, SC, United States; Drug Prevention and Health Branch, Division for Operations, United States; Connecticut Council on Problem Gambling, Connecticut Mental Health Center, Yale School of Medicine, New Haven, CT, United States; Laureate Institute for Brain Research, Tulsa, OK, United States; School of Medicine, University of St Andrews, St Andrews, United Kingdom; Office on Drugs and Crime, Vienna, Austria; Prof. Dr. Matei Bals- Arena OMT Department, National Institute for Infectious Diseases, Bucharest, Romania; Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Alamal psychiatric hospital, Dubai, United Arab Emirates; Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Al Ahliyya Amman University, Amman, Jordan; Ministry of Health, Muscat, Oman; Department of Psychiatry and National Drug Dependence Treatment Center (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Faculty of Medicine, Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; State Drug Dependence Treatment Center, Institute of Mental Health, Pt BDS University of Health Sciences, Rohtak, India; Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria; Addiction medicine clinic, Amman, Jordan; Department of Psychiatry, Drug De-addiction & Treatment Center, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Addiction medicine clinic, Mila, Algeria; Center medical Marmottan, Paris, France; Réseau de Prévention des Addictions (RESPADD), Paris, France; Department of Psychiatry and Behavioral Neurosciences, Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Geneva University Hospitals, Geneva, Switzerland; CUNY School of Medicine, New York, NY, United States; AÄ¡enzija Sedqa, Santa Venera, Malta; United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Department of Medicine and Surgery, University Milan-Bicocca, Milan, Italy; University Psychiatric Hospital Vrapce, Zagreb, Croatia; Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, India; Addiction medicine clinic, Mexico City, Mexico; Addiction Crisis Solutions, Louisville, KY, United States; Department of Psychology, Indiana University Purdue University - Indianapolis, Indianapolis, IN, United States; SerT Lentini, ASP Siracusa, Syracuse, Italy; Serenity Vista Addiction Treatment Center, Jaramillo, Panama; Department of Psychiatry, ESIC Medical College, Hyderabad, India; National Institute of Mental Health, Klecany, Czech Republic; Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp University (UA), Antwerp, Belgium; Drug & Alcohol Clinical Services, Hunter New England Local Health District, New Lambton, NSW, Australia; Ain Shams University, Cairo, Egypt; Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Center for Research and Information on Substance Abuse, Jos, Nigeria; Addiction Medicine Clinic, Damascus, Syrian Arab Republic; European Monitoring Center for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal; 2nd Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece; Brown University and Lifespan Health System, Providence, RI, United States; Fuderanan Mental Health Clinic, Manila, Philippines; Georgian Harm Reduction Network, Tbilisi, Georgia; Organization Against Drugs, Primary Care Health Center, Veria, Greece; Addictions Services (Ser.D.), Department of Territorial Assistance, ASL Teramo, Teramo, Italy; Swansea University Medical School, Institute of Life Sciences 2, Sketty, United Kingdom; Hospital Borda, Universidad de Buenos Aires, Buenos Aires, Argentina; University of Sydney, Sydney, NSW, Australia; Institutes for Cognitive Science Studies (IRICSS), Brain and Cognition Clinic, Tehran, Iran; Tehran University of Medical Sciences, Tehran, Iran; Department of Anesthesiology, Yale University, New Haven, CT, United States; Drugs Rehabilitation Center, National Narcotics Board of Indonesia, East Jakarta, Indonesia; Department of Psychiatry, Universitas Padjadjaran, Bandung, Indonesia; Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; Univeristi Malaysia Sabah, Sabah, Malaysia; Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; National Center for Mental Health of Korea, Seoul, South Korea; Republican Center for Addictive Disorders, Vilnius, Lithuania; Addiction medicine clinic, Skopje, North Macedonia; Naufar Institute, Doha, Qatar; The Kantchelov Clinic, Sofia, Bulgaria; Mount Sinai Medical Center, New York, NY, United States; African Institute for Development Policy, Lilongwe, Malawi; Sobriety Centers of New Hampshire, Antrim, NH, United States; Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Department of Neuropsychiatry, Pusan National University Yangsan Hospital, Yangsan, South Korea; Chatham House, Washington, United States; Institute for Public Health of Split-Dalmatia County, Split, Croatia; Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, Indonesia; Scripps Mercy Hospital, San Diego, CA, United States; Department of Psychiatry, The Catholic University of Korea, Seoul, South Korea; Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania; Tel Aviv University, Tel Aviv, Israel; Israel Center on Addiction, Netanya, Israel; Community Health Work, Dar es Salaam, Tanzania; Hayat Center for Treatment and Psycho-social Rehabilitation, Khartoum, Sudan; University of Botswana, Gaborone, Botswana; V.P. Dole, Dual Disorder Unit, Santa Chiara University Hospital, University of Pisa, Pisa, Italy; CAS Girona, Department of Psychology, University of Girona, Girona, Spain; Community addiction team, Southern Health and Social Care Trust, Craigavon, United Kingdom; Priority Medical Clinic, Dublin, Ireland; Save the Children International, Yangon, Myanmar; Dirección de Investigaciones Epidemiológicas y Sociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico; Department of Psychiatry, Faculty of Medicine, Sir John Kotelawala Defense University, Colombo, Sri Lanka; Center for Addiction Medicine, NIMHANS, Bangalore, India; Kleopatra Kodric, Irena Nisic, Ljubljana, Slovenia; Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa; NIMHANS, Bangalore, India; Department of Psychiatry, Center for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India; Federal Neuropsychiatric Hospital, Calabar, Nigeria; Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, Iran; Institute of Psychiatry, WHO Collaborating Center for Mental Health, Rawalpindi, Pakistan; Brijder Addiction Care, Zaandam, Netherlands; Department of Clinical Neurosciences/DIMSC, Unit of Clinical Psychiatry, School of Medicine, Polytechnic University of Marche, Ancona, Italy; Koh Kong Provincial Hospital, Phoumin, Cambodia; Kaiser Permanente, Oakland, CA, United States; Psychiatric hospital Sveti Ivan, Zagreb, Croatia; Department of Psychiatry and mental health, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Universidad de El Salvador, San Salvador, El Salvador; AddiPsy, Lyon, France; Addiction medicine clinic, San José, Costa Rica; Novadic-Kentron Addiction Care Network, Vught, Netherlands; Phoenix Foundation for Research and Development, Lahore, Pakistan; Barwon Health, Geelong, VIC, Australia; Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand; University of the Sunshine Coast (USC), QueenslandQLD, Australia; Center for Interdisciplinary Addiction Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Drugs Rehabilitation Center, National Narcotics Board of Indonesia, East Jakarta, Indonesia; Department of Cognitive Psychology, Institute for Cognitive Science Studies, Tehran, Iran; Usher Institute, University of Edinburgh, Edinburgh, United Kingdom; Psychiatry Service, University of Salamanca Health Care Complex, School of Medicine, University of Salamanca, Salamanca, Spain; PGIMER, Chandigarh, India; Street Health Center, Kingston, ON, Canada; Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck, Innsbruck, Austria; Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Medical School, University of Cyprus, Cyprus; Clínica Psiquiátrica de la Facultad de Medicina, Uruguay; Center for Treatment of Drug addiction, University Psychiatric Clinic, Ljubljana, Slovenia; Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lagankhel, Nepal; Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China; Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Hokkaido, Japan; Department of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Health Professions Councils of Namibia, Windhoek, Namibia; Addiction medicine clinic, Montevideo, Uruguay; Republican Center for Addictive Disorders, Vilnius, Lithuania; Asociasion Programa Andres Argentina, Santa Fe, Argentina; Mazandaran University of Medical Sciences, Mazandaran, Iran; MRC/CSO SPHSU, University of Glasgow, Glasgow, United Kingdom; Gladsaxe Substance Use Disorder Treatment Center, Gladsaxe, Denmark; Institut de Neuropsiquiatria i Addiccions, IMIM-Hospital del Mar, Medical Research, Barcelona, Spain; NACADA, Nairobi, Kenya; Waikato District Health Board (WDHB) Hamilton, Hamilton, New Zealand; Institute of Addiction Medicine, Plymouth Meeting, PA, United States; Jellinek, Amsterdam, Netherlands; Addictions Foundation of Manitoba, Manitoba, Canada; Thanyarak Chiangmai hospital, Khilek, Thailand; Medical University of Warsaw, Warsaw, Poland; Jimma University, Jimma, Ethiopia; Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran |
Radfar, S.R., Department of Neuroscience and Addiction, School of Advanced Technologies in Medicine (SATiM), Tehran University of Medical Sciences, Tehran, Iran, Integrated Substance Abuse Programs Department, University of California, Los Angeles, Los Angeles, CA, United States; De Jong, C.A.J., Behavioral Science Institute Radboud University, Nijmegen, Netherlands; Farhoudian, A., Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Ebrahimi, M., Materials and Energy Research Center, Tehran, Iran, Iranian National Center for Addiction Studies, Tehran University of Medical Sciences, Tehran, Iran; Rafei, P., Department of Psychology, Faculty of Psychology and Education, University of Tehran, Tehran, Iran; Vahidi, M., Department of Psychiatry, Tehran University of Medical Sciences, Tehran, Iran; Yunesian, M., School of Public Health, Tehran University of Medical Sciences, Tehran, Iran; Kouimtsidis, C., Surrey and Borders Partnership, NHS Foundation Trust, Leatherhead, United Kingdom; Arunogiri, S., Turning Point, Eastern Health, Box Hill, VIC, Australia; Massah, O., Substance Abuse and Dependence Research Center, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran; Deylamizadeh, A., Rebirth Charity Society NGO, Tehran, Iran; Brady, K.T., Medical University of South Carolina, Charleston, SC, United States; Busse, A., Drug Prevention and Health Branch, Division for Operations, United States, Office on Drugs and Crime, Vienna, Austria; Potenza, M.N., Connecticut Council on Problem Gambling, Connecticut Mental Health Center, Yale School of Medicine, New Haven, CT, United States; Ekhtiari, H., Laureate Institute for Brain Research, Tulsa, OK, United States; Baldacchino, A.M., School of Medicine, University of St Andrews, St Andrews, United Kingdom; Abagiu, A.O., Prof. Dr. Matei Bals- Arena OMT Department, National Institute for Infectious Diseases, Bucharest, Romania; Abouna, F.D.N., Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon; Ahmed, M.H., Alamal psychiatric hospital, Dubai, United Arab Emirates; Al-ansari, B., Sydney Medical School, University of Sydney, Sydney, NSW, Australia; Mahmmoud Abu Al-khair, F., Al Ahliyya Amman University, Amman, Jordan; Almaqbali, M.H., Ministry of Health, Muscat, Oman; Ambekar, A., Department of Psychiatry and National Drug Dependence Treatment Center (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Ardabili, H.M., Faculty of Medicine, Psychiatry and Behavioral Sciences Research Center, Ibn-e-Sina Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; Arya, S., State Drug Dependence Treatment Center, Institute of Mental Health, Pt BDS University of Health Sciences, Rohtak, India; Lasebikan, V.O., Department of Psychiatry, College of Medicine, University of Ibadan, Ibadan, Nigeria; Ayasreh, M.A., Addiction medicine clinic, Amman, Jordan; Basu, D., Department of Psychiatry, Drug De-addiction & Treatment Center, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Benmebarek, Z., Addiction medicine clinic, Mila, Algeria; Bhad, R., Department of Psychiatry and National Drug Dependence Treatment Center (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Blaise, M., Center medical Marmottan, Paris, France; Bonnet, N., Réseau de Prévention des Addictions (RESPADD), Paris, France; Brasch, J., Department of Psychiatry and Behavioral Neurosciences, Michael DeGroote School of Medicine, McMaster University, Hamilton, ON, Canada; Broers, B., Geneva University Hospitals, Geneva, Switzerland; Butner, J.L., CUNY School of Medicine, New York, NY, United States; Camilleri, M., AÄ¡enzija Sedqa, Santa Venera, Malta; Campello, G., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Carra, G., Department of Medicine and Surgery, University Milan-Bicocca, Milan, Italy; Celic, I., University Psychiatric Hospital Vrapce, Zagreb, Croatia; Chalabianloo, F., Department of Addiction Medicine, Haukeland University Hospital, Bergen, Norway; Chaturvedi, A., Department of Biochemistry, Melaka Manipal Medical College, Manipal Academy of Higher Education, Manipal, India; de Jesús Eduardo Noyola Cherpitel, J., Addiction medicine clinic, Mexico City, Mexico; Clark, K.J., Addiction Crisis Solutions, Louisville, KY, United States; Cyders, M.A., Department of Psychology, Indiana University Purdue University - Indianapolis, Indianapolis, IN, United States; de Bernardis, E., SerT Lentini, ASP Siracusa, Syracuse, Italy; Derry, J.E., Serenity Vista Addiction Treatment Center, Jaramillo, Panama; Dhagudu, N.K., Department of Psychiatry, ESIC Medical College, Hyderabad, India; Dolezalova, P., National Institute of Mental Health, Klecany, Czech Republic; Dom, G., Collaborative Antwerp Psychiatric Research Institute (CAPRI), Antwerp University (UA), Antwerp, Belgium; Dunlop, A.J., Drug & Alcohol Clinical Services, Hunter New England Local Health District, New Lambton, NSW, Australia; Elhabiby, M.M., Ain Shams University, Cairo, Egypt; Elkholy, H., Department of Neurology and Psychiatry, Faculty of Medicine, Ain Shams University, Cairo, Egypt; Essien, N.F., Center for Research and Information on Substance Abuse, Jos, Nigeria; Farah, G.I., Addiction Medicine Clinic, Damascus, Syrian Arab Republic; Ferri, M., European Monitoring Center for Drugs and Drug Addiction (EMCDDA), Lisbon, Portugal; Floros, G.D., 2nd Department of Psychiatry, Aristotle University of Thessaloniki, Thessaloniki, Greece; Friedman, C., Brown University and Lifespan Health System, Providence, RI, United States; Fuderanan, C.H., Fuderanan Mental Health Clinic, Manila, Philippines; Gerra, G., Geneva University Hospitals, Geneva, Switzerland; Ghosh, A., Department of Psychiatry, Drug De-addiction & Treatment Center, Postgraduate Institute of Medical Education & Research, Chandigarh, India; Gogia, M., Georgian Harm Reduction Network, Tbilisi, Georgia; Grammatikopoulos, I.A., Organization Against Drugs, Primary Care Health Center, Veria, Greece; Grandinetti, P., Addictions Services (Ser.D.), Department of Territorial Assistance, ASL Teramo, Teramo, Italy; Guirguis, A., Swansea University Medical School, Institute of Life Sciences 2, Sketty, United Kingdom; Gutnisky, D., Hospital Borda, Universidad de Buenos Aires, Buenos Aires, Argentina; Haber, P.S., University of Sydney, Sydney, NSW, Australia; Hassani-Abharian, P., Institutes for Cognitive Science Studies (IRICSS), Brain and Cognition Clinic, Tehran, Iran; Hooshyari, Z., Tehran University of Medical Sciences, Tehran, Iran; Ibrahim, I.I.M., Ain Shams University, Cairo, Egypt; Ieong, H., Department of Anesthesiology, Yale University, New Haven, CT, United States; Indradewi, R.N., Drugs Rehabilitation Center, National Narcotics Board of Indonesia, East Jakarta, Indonesia; Iskandar, S., Department of Psychiatry, Universitas Padjadjaran, Bandung, Indonesia; Jain, S., Department of Psychiatry, Heritage Institute of Medical Sciences (HIMS), Varanasi, India; James, S., Univeristi Malaysia Sabah, Sabah, Malaysia; Javadi, S.M.H., Department of Social Work, University of Social Welfare & Rehabilitation Sciences, Tehran, Iran; Joe, K.H., National Center for Mental Health of Korea, Seoul, South Korea; Jokubonis, D., Republican Center for Addictive Disorders, Vilnius, Lithuania; Jovanova, A.T., Addiction medicine clinic, Skopje, North Macedonia; Kamal, R.M., Naufar Institute, Doha, Qatar; Kantchelov, A.I., The Kantchelov Clinic, Sofia, Bulgaria; Kathiresan, P., Department of Psychiatry and National Drug Dependence Treatment Center (NDDTC), All India Institute of Medical Sciences (AIIMS), New Delhi, India; Katzman, G., Mount Sinai Medical Center, New York, NY, United States; Kawale, P., African Institute for Development Policy, Lilongwe, Malawi; Kern, A.M., Sobriety Centers of New Hampshire, Antrim, NH, United States; Kessler, F.H.P., Federal University of Rio Grande do Sul, Porto Alegre, Brazil; Kim, S., Department of Neuropsychiatry, Pusan National University Yangsan Hospital, Yangsan, South Korea; Kimball, A.M., Chatham House, Washington, United States; Kljucevic, Z., Institute for Public Health of Split-Dalmatia County, Split, Croatia; Siste, K., Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital, Jakarta, Indonesia; Lev, R., Scripps Mercy Hospital, San Diego, CA, United States; Lee, H.K., Department of Psychiatry, The Catholic University of Korea, Seoul, South Korea; Lengvenyte, A., Faculty of Medicine, Institute of Clinical Medicine, Psychiatric Clinic, Vilnius University, Vilnius, Lithuania; Lev-ran, S., Tel Aviv University, Tel Aviv, Israel, Israel Center on Addiction, Netanya, Israel; Mabelya, G.S., Community Health Work, Dar es Salaam, Tanzania; Mahi, M.A.E., Hayat Center for Treatment and Psycho-social Rehabilitation, Khartoum, Sudan; Maphisa, J., University of Botswana, Gaborone, Botswana; Maremmani, I., V.P. Dole, Dual Disorder Unit, Santa Chiara University Hospital, University of Pisa, Pisa, Italy; Masferrer, L., CAS Girona, Department of Psychology, University of Girona, Girona, Spain; McCambridge, O., Community addiction team, Southern Health and Social Care Trust, Craigavon, United Kingdom; McGovern, G.G., Priority Medical Clinic, Dublin, Ireland; Min, A.K., Save the Children International, Yangon, Myanmar; Moghanibashi-Mansourieh, A., National Center for Mental Health of Korea, Seoul, South Korea; Mora-Rios, J., Dirección de Investigaciones Epidemiológicas y Sociales, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Mexico City, Mexico; Mudalige, I.U.K., Department of Psychiatry, Faculty of Medicine, Sir John Kotelawala Defense University, Colombo, Sri Lanka; Mukherjee, D., Center for Addiction Medicine, NIMHANS, Bangalore, India; Munira, P.M., Kleopatra Kodric, Irena Nisic, Ljubljana, Slovenia; Myers, B., Alcohol Tobacco and Other Drug Research Unit, South African Medical Research Council, Cape Town, South Africa; Menon T N, J., NIMHANS, Bangalore, India; Narasimha, V.L., Department of Psychiatry, Center for Addiction Medicine, National Institute of Mental Health and Neurosciences, Bengaluru, India; Ndionuka, N., Federal Neuropsychiatric Hospital, Calabar, Nigeria; Nejatisafa, A., Department of Psychiatry, Psychosomatic Research Center, Tehran University of Medical Sciences, Tehran, Iran; Niaz, K., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Nizami, A.T., Institute of Psychiatry, WHO Collaborating Center for Mental Health, Rawalpindi, Pakistan; Nuijens, J.H., Brijder Addiction Care, Zaandam, Netherlands; Orsolini, L., Department of Clinical Neurosciences/DIMSC, Unit of Clinical Psychiatry, School of Medicine, Polytechnic University of Marche, Ancona, Italy; Oum, V., Koh Kong Provincial Hospital, Phoumin, Cambodia; Oyemade, A.A., Kaiser Permanente, Oakland, CA, United States; Palavra, I.R., Psychiatric hospital Sveti Ivan, Zagreb, Croatia; Pant, S.B., Department of Psychiatry and mental health, Institute of Medicine, Tribhuvan University, Kirtipur, Nepal; Paredes, J., Universidad de El Salvador, San Salvador, El Salvador; Peyron, E., AddiPsy, Lyon, France; Alberto Quirós, R., Addiction medicine clinic, San José, Costa Rica; Qurishi, R., Novadic-Kentron Addiction Care Network, Vught, Netherlands; Rafiq, N.U.Z., Phoenix Foundation for Research and Development, Lahore, Pakistan; Rao, R.R., Barwon Health, Geelong, VIC, Australia; Ratta-apha, W., Faculty of Medicine Siriraj Hospital, Mahidol University, Salaya, Thailand; Raymond, K., University of the Sunshine Coast (USC), QueenslandQLD, Australia; Reimer, J., Center for Interdisciplinary Addiction Research, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; Renaldo, E., Drugs Rehabilitation Center, National Narcotics Board of Indonesia, East Jakarta, Indonesia; Rezapour, T., Department of Cognitive Psychology, Institute for Cognitive Science Studies, Tehran, Iran; Robertson, J.R., Usher Institute, University of Edinburgh, Edinburgh, United Kingdom; Roncero, C., Psychiatry Service, University of Salamanca Health Care Complex, School of Medicine, University of Salamanca, Salamanca, Spain; Roub, F., PGIMER, Chandigarh, India; Rubenstein, E.J., Street Health Center, Kingston, ON, Canada; Rupp, C.I., Department of Psychiatry, Psychotherapy, and Psychosomatics, Medical University Innsbruck, Innsbruck, Austria; Saenz, E., United Nations Office on Drugs and Crime (UNODC), Vienna, Austria; Salehi, M., Department of Neurosciences and Addiction Studies, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Samartzis, L., Medical School, University of Cyprus, Cyprus; Sarubbo, L.B., Clínica Psiquiátrica de la Facultad de Medicina, Uruguay; Segrec, N., Center for Treatment of Drug addiction, University Psychiatric Clinic, Ljubljana, Slovenia; Shah, B., Department of Psychiatry, Patan Academy of Health Sciences, School of Medicine, Lagankhel, Nepal; Shen, H., Department of Psychiatry, Second Xiangya Hospital, Central South University, Changsha, China; Shirasaka, T., Department of Psychiatry, Teine Keijinkai Medical Center, Sapporo, Hokkaido, Japan; Shoptaw, S., Department of Family Medicine, David Geffen School of Medicine at UCLA, Los Angeles, CA, United States; Sintango, F.M., Health Professions Councils of Namibia, Windhoek, Namibia; Sosa, V.A., Addiction medicine clinic, Montevideo, Uruguay; Subata, E., Republican Center for Addictive Disorders, Vilnius, Lithuania; Sztycberg, N., Asociasion Programa Andres Argentina, Santa Fe, Argentina; Taghizadeh, F., Mazandaran University of Medical Sciences, Mazandaran, Iran; Teck, J., MRC/CSO SPHSU, University of Glasgow, Glasgow, United Kingdom; Tjagvad, C., Gladsaxe Substance Use Disorder Treatment Center, Gladsaxe, Denmark; Torrens, M., Institut de Neuropsiquiatria i Addiccions, IMIM-Hospital del Mar, Medical Research, Barcelona, Spain; Twala, J.M., NACADA, Nairobi, Kenya; Vadivel, R., Waikato District Health Board (WDHB) Hamilton, Hamilton, New Zealand; Volpicelli, J.R., Institute of Addiction Medicine, Plymouth Meeting, PA, United States; Weijs, J., Jellinek, Amsterdam, Netherlands; Wintoniw, S.M., Addictions Foundation of Manitoba, Manitoba, Canada; Wittayanookulluk, A., Thanyarak Chiangmai hospital, Khilek, Thailand; Wojnar, M., Medical University of Warsaw, Warsaw, Poland; Yasir, S., Institute of Psychiatry, WHO Collaborating Center for Mental Health, Rawalpindi, Pakistan; Yitayih, Y., Jimma University, Jimma, Ethiopia; Zhao, M., Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Zonoozi, A.K., Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; ISAM-PPIG Global Survey Consortium |
Background: The coronavirus disease 2019 (COVID-19) pandemic has impacted people with substance use disorders (SUDs) worldwide, and healthcare systems have reorganized their services in response to the pandemic. Methods: One week after the announcement of the COVID-19 as a pandemic, in a global survey, 177 addiction medicine professionals described COVID-19-related health responses in their own 77 countries in terms of SUD treatment and harm reduction services. The health responses were categorized around (1) managerial measures and systems, (2) logistics, (3) service providers, and (4) vulnerable groups. Results: Respondents from over 88% of countries reported that core medical and psychiatric care for SUDs had continued; however, only 56% of countries reported having had any business continuity plan, and 37.5% of countries reported shortages of methadone or buprenorphine supplies. Participants of 41% of countries reported partial discontinuation of harm-reduction services such as needle and syringe programs and condom distribution. Fifty-seven percent of overdose prevention interventions and 81% of outreach services were also negatively impacted. Conclusions: Participants reported that SUD treatment and harm-reduction services had been significantly impacted globally early during the COVID-19 pandemic. Based on our findings, we highlight several issues and complications resulting from the pandemic concerning people with SUDs that should be tackled more efficiently during the future waves or similar pandemics. The issues and potential strategies comprise the following: (1) helping policymakers to generate business continuity plans, (2) maintaining the use of evidence-based interventions for people with SUDs, (3) being prepared for adequate medication supplies, (4) integrating harm reduction programs with other treatment modalities, and (5) having specific considerations for vulnerable groups such as immigrants and refugees. © Copyright © 2021 Radfar, De Jong, Farhoudian, Ebrahimi, Rafei, Vahidi, Yunesian, Kouimtsidis, Arunogiri, Massah, Deylamizadeh, Brady, Busse, ISAM-PPIG Global Survey Consortium, Potenza, Ekhtiari and Baldacchino. |
addiction services; COVID-19 pandemic; drug policy; harm reduction; opioid agonist treatment; public health; substance use disorder |
buprenorphine; methadone; adult; Article; commercial phenomena; controlled study; coronavirus disease 2019; drug dependence; drug dependence treatment; drug shortage; female; geographic distribution; harm reduction; health care access; health care management; health care personnel; health care policy; health care system; health program; high income country; human; immigrant; low income country; male; mental health care; mental health service; middle aged; middle income country; pandemic; questionnaire; refugee |
Frontiers Media S.A. |
16640640 |
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Article |
Q1 |
1363 |
2668 |
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427 |
Setiati S., Soejono C.H., Harimurti K., Dwimartutie N., Aryana I.G.P.S., Sunarti S., Budiningsih F., Mulyana R., Dwipa L., Sudarso A., Rensa R., Istanti R., Azwar M.K., Marsigit J. |
14325991900;24472241900;23473513200;37067234900;37062993600;57215563311;56483278600;57203246879;55321762700;57223602321;6504343309;23496653300;57202798959;57218912589; |
Frailty and Its Associated Risk Factors: First Phase Analysis of Multicentre Indonesia Longitudinal Aging Study |
2021 |
Frontiers in Medicine |
8 |
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658580 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105939470&doi=10.3389%2ffmed.2021.658580&partnerID=40&md5=b2d32afefa94ab6754eec53482b82d31 |
Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia |
Setiati, S., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Soejono, C.H., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Harimurti, K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Dwimartutie, N., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Aryana, I.G.P.S., Department of Internal Medicine, Faculty of Medicine, Universitas Udayana, Bali, Indonesia; Sunarti, S., Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Budiningsih, F., Department of Internal Medicine, Faculty of Medicine, Universitas Sebelas Maret, Solo, Indonesia; Mulyana, R., Department of Internal Medicine, Faculty of Medicine, Universitas Andalas, Padang, Indonesia; Dwipa, L., Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Bandung, Indonesia; Sudarso, A., Department of Internal Medicine, Faculty of Medicine, Universitas Hasanuddin, Makasar, Indonesia; Rensa, R., Department of Internal Medicine, Faculty of Medicine, Universitas Atma Jaya, Jakarta, Indonesia; Istanti, R., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Azwar, M.K., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia; Marsigit, J., Division of Geriatrics, Department of Internal Medicine, Faculty of Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia, Jakarta, Indonesia |
Background: National long-term care development requires updated epidemiological data related to frailty. We aimed to find the prevalence of frailty and its associated factors among Indonesian elderly. Methods: We conducted first-phase cross-sectional analysis of Indonesia Longitudinal Aging Study (INALAS) data collected from community-dwelling outpatients aged 60 years and older without acute illness in nine geriatric service care centres. Descriptive, bivariate and multivariate analyses were conducted. Results: Among 908 elderly in this study, 15.10% were robust, 66.20% were pre-frail, and 18.70% were frail. Functional dependence was associated with frailty among Indonesian elderly (OR 5.97, 95% CI 4.04–8.80). Being depressed and at risk for malnutrition were also associated with frailty with OR 2.54, 95% CI 1.56–4.12, and OR 2.56, 95% CI 1.68–3.90, respectively. Prior history of fall (OR 1.77, 95% CI 1.16–2.72) and hospitalization (OR 1.46, 95% CI 0.97–2.20) in the previous 12 months were associated with frailty. There is also significant association between poly pharmacy and frailty (OR 2.42, 95% CI 1.50–3.91). Conclusion: Approximately one in five Indonesian community-dwelling elderly was frail. Frailty is associated with functional dependence, being at risk for malnutrition or being malnourished, depression, history of fall, history of hospitalization, and poly pharmacy. There may be bidirectional relationships between the risk factors and frailty. The development of long-term care in Indonesia should be considered, without forcing the elderly who need it. © Copyright © 2021 Setiati, Soejono, Harimurti, Dwimartutie, Aryana, Sunarti, Budiningsih, Mulyana, Dwipa, Sudarso, Rensa, Istanti, Azwar and Marsigit. |
community-dwelling elderly; frailty; Indonesia; long-term care; prevalence; risk factors |
adult; aged; aging; Article; community dwelling person; cross-sectional study; depression; falling; female; frailty; functional status; high risk population; hospitalization; human; Indonesian; longitudinal study; major clinical study; male; malnutrition; medical history; outpatient; polypharmacy; prevalence; risk factor |
Frontiers Media S.A. |
2296858X |
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Article |
Q1 |
1388 |
2608 |
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432 |
Aitken R.J., Curry B.J., Shokri S., Pujianto D.A., Gavriliouk D., Gibb Z., Whiting S., Connaughton H.S., Nixon B., Salamonsen L.A., Baker M.A. |
7201959888;56908506100;8856710600;8745734300;56926729700;36650800200;55363694400;55488741500;34571659200;7005800278;57201355280; |
Evidence that extrapancreatic insulin production is involved in the mediation of sperm survival |
2021 |
Molecular and Cellular Endocrinology |
526 |
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111193 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101239641&doi=10.1016%2fj.mce.2021.111193&partnerID=40&md5=dd3268ec7434c8487b5f42a0d81d0e4a |
Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia |
Aitken, R.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Curry, B.J., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Shokri, S., Department of Anatomical Sciences, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran; Pujianto, D.A., Department of Biology, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Gavriliouk, D., Family Fertility Centre, Ashford Specialist CentreSA 5035, Australia; Gibb, Z., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Whiting, S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Connaughton, H.S., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia; Nixon, B., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia; Salamonsen, L.A., Hudson Institute of Medical Research, Centre for Reproductive Health, Monash UniversityVIC 3168, Australia; Baker, M.A., Priority Research Centre for Reproductive Science, Faculty of Science and Faculty of Health and Medicine, University of Newcastle, Callaghan, NSW 2308, Australia, Hunter Medical Research Institute, New Lambton HeightsNSW 2305, Australia |
Evidence is presented for expression of the insulin receptor on the surface of mammalian spermatozoa as well as transcripts for the receptor substrate adaptor proteins (IRS1-4) needed to mediate insulin action. Exposure to this hormone resulted in insulin receptor phosphorylation (pTyr972), activation of AKT (pSer473) and the stimulation of sperm motility. Intriguingly, the male germ line is also shown to be capable of generating insulin, possessing the relevant mRNA transcript and expressing strong immunocytochemical signals for both insulin and C-peptide. Insulin could be released from the spermatozoa by sonication in a concentration-dependent manner but was not secreted in response to glucose, fructose or stimulation with progesterone. However, insulin release could be induced by factors present in human uterine lavages. Furthermore, the endometrium was also shown to possess the machinery for insulin production and action (mRNA, insulin, C-peptide, proprotein convertase and insulin receptor), releasing insulin into the uterine lumen prior to ovulation. These studies emphasize the fundamental importance of extra-pancreatic insulin in regulating the reproductive process, particularly in the support of spermatozoa on their perilous voyage to the site of fertilization. © 2021 Elsevier B.V. |
AKT-1; Apoptosis; Insulin; Motility; Spermatozoa |
C peptide; fructose; glucose; insulin; insulin receptor; messenger RNA; progesterone; proprotein convertase 1; proprotein convertase 3; protein kinase B; serine proteinase; unclassified drug; C peptide; insulin; insulin receptor; insulin receptor substrate; isoprotein; adult; animal tissue; Article; controlled study; enzyme activation; female; fertilization; human; immunocytochemistry; insulin release; male; mouse; nested polymerase chain reaction; nonhuman; ovulation; protein function; protein phosphorylation; protein RNA binding; real time polymerase chain reaction; spermatozoon motility; animal; biosynthesis; cell survival; cytology; endometrium; epithelium; germ cell; mammal; metabolism; pancreas; rat; spermatozoon; uterus; Animals; C-Peptide; Cell Survival; Endometrium; Epithelium; Fe |
Elsevier Ireland Ltd |
03037207 |
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33610643 |
Article |
Q1 |
1296 |
2909 |
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454 |
Siste K., Hanafi E., Sen L.T., Wahjoepramono P.O.P., Kurniawan A., Yudistiro R. |
55644113100;56737010600;57219034101;57216247534;56521213900;57041205200; |
Erratum: Potential correlates of internet gaming disorder among Indonesian medical students: Cross-sectional study (Journal of Medical Internet Research (2021) 23:4 (e25468) DOI: 10.2196/25468) |
2021 |
Journal of Medical Internet Research |
23 |
4 |
e29790 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105627812&doi=10.2196%2f29790&partnerID=40&md5=81d33d24852e7aee04557d088a3802cd |
Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospital, Tangerang, Indonesia |
Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Sen, L.T., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wahjoepramono, P.O.P., Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia; Kurniawan, A., Department of Internal Medicine, Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospital, Tangerang, Indonesia; Yudistiro, R., Faculty of Medicine, Universitas Pelita Harapan, Siloam Hospitals, Tangerang, Indonesia |
In “Potential Correlates of Internet Gaming Disorder Among Indonesian Medical Students: Cross-sectional Study” (J Med Internet Res 2021;23(4):e25468) the authors noted two errors. Due to a system error, the name of one author, Andree Kurniawan, was replaced with the name of another author on the paper, Ryan Yudistiro. In the originally published paper, the order of authors was listed as follows: Kristiana Siste; Enjeline Hanafi; Lee Thung Sen; Petra Octavian Perdana Wahjoepramono; Ryan Yudistiro; Ryan Yudistiro This has been corrected to: Kristiana Siste; Enjeline Hanafi; Lee Thung Sen; Petra Octavian Perdana Wahjoepramono; Andree Kurniawan; Ryan Yudistiro In the originally published paper, the ORCID number of author Ryan Yudistiro was incorrectly published as follows: 0000-0002-5219-9029 This has been corrected to: 0000-0003-1418-2661 The correction will appear in the online version of the paper on the JMIR Publications website on April 21, 2021, together with the publication of this correction notice. Because this was made after submission to PubMed, PubMed Central, and other full-text repositories, the corrected article has also been resubmitted to those repositories. © Kristiana Siste, Enjeline Hanafi, Lee Thung Sen, Petra Octavian Perdana Wahjoepramono, Andree Kurniawan, Ryan Yudistiro. |
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erratum |
JMIR Publications Inc. |
14388871 |
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33882024 |
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1446 |
2408 |
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