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Sperber A.D., Bangdiwala S.I., Drossman D.A., Ghoshal U.C., Simren M., Tack J., Whitehead W.E., Dumitrascu D.L., Fang X., Fukudo S., Kellow J., Okeke E., Quigley E.M.M., Schmulson M., Whorwell P., Archampong T., Adibi P., Andresen V., Benninga M.A., Bonaz B., Bor S., Fernandez L.B., Choi S.C., Corazziari E.S., Francisconi C., Hani A., Lazebnik L., Lee Y.Y., Mulak A., Rahman M.M., Santos J., Setshedi M., Syam A.F., Vanner S., Wong R.K., Lopez-Colombo A., Costa V., Dickman R., Kanazawa M., Keshteli A.H., Khatun R., Maleki I., Poitras P., Pratap N., Stefanyuk O., Thomson S., Zeevenhooven J., Palsson O.S. |
55222586700;57224646613;57189767321;7005966711;57202571330;7102745366;16154954100;7005124531;57220861049;57219719431;57204305024;6701372042;7103105068;55993764500;35243963700;56401993900;56229001100;13805283000;7003532912;7004197628;7004013649;6701734343;7408119608;7006168774;6603069136;57204159889;7005446863;56191149300;6603579531;57216556340;7402389020;36469259800;8443384400;7005049888;55499852700;6504805230;56435522900;35965540900;7202046963;15765371700;57212081425;18935849300;35944673000;35249230500;56657486600;7202276913;57191854958;6603768529; |
Worldwide Prevalence and Burden of Functional Gastrointestinal Disorders, Results of Rome Foundation Global Study |
2021 |
Gastroenterology |
160 |
1 |
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99 |
114.e3 |
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233 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097793980&doi=10.1053%2fj.gastro.2020.04.014&partnerID=40&md5=db0ef85211fc480b0dc645b05ce86665 |
Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada; Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, NC, United States; Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium; Center for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Discipline of Medicine, Northern Clinical School, University of Sydney, Sydney, Australia; Department of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Nigeria; Lynda K. and David M. Underwood Center for Digestive Disorder, Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, United States; Laboratory of Liver, Pancreas and Motility (HIPAM), Unit of Research in Experimental Medicine, Faculty of Medicine, Universidad Nacional Autónoma de Mexico (UNAM). Hospital General de México, Mexico City, Mexico; Neurogastroenterology Unit, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom; Department of Medicine, University of Ghana School of Medicine and Dentistry, Accra, Ghana; Integrative Functional Gastroenterology Research Center, Department of Internal Medicine, School of Medicine, Isfahan University of Medical SciencesIsfahan, Iran; Department of Medicine, Israelitic Hospital, Hamburg, Germany; Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Amsterdam, The Netherlands, Netherlands; Service d'Hépato-Gastroentérologie, CHU Grenoble Alpes, Grenoble, France; Ege University School of Medicine, Division of Gastroenterology, Bornova Izmir, Turkey; “Centro Medico Dr. Bustos Fernandez”, Buenos Aires, Argentina; Department of Gastroenterology, School of Medicine, Wonkwang University, Iksan, South Korea; Department of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Italy; Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Gastroenterology Unit, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia; Department of Outpatient Medicine, Faculty of Internal Medicine, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia; Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland; Dhaka Medical College & Hospital, Dhaka, Bangladesh; Department of Gastroenterology, University Hospital Vall d'Hebron, Autonomous University of Barcelona & Neuro-Inmuno-Gastroenterology Lab, Vall d'Hebron Research Institute, Barcelona, Spain; Department of Medicine, Division of Gastroenterology, University of Cape Town, Cape Town, South Africa; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gastrointestinal Diseases Research Unit, Kingston Health Science Centre, Queen's University, Kingston, ON, Canada; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore; UMAE Hospital de Especialidades C.M.N. Manuel Avila Camacho, Puebla Pue, Mexico; Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel-Aviv, Israel; CEGIIR-Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Gut and Liver Research Center, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran; CHUM, Université de Montréal, Montréal, QC, Canada; KIMS Hospitals, Secunderabad, India; Department of Biochemical Markers of Chronic Non-Communicable Diseases Research National Medical Research Centre for Preventive Medicine, Moscow, Russian Federation |
Sperber, A.D., Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel; Bangdiwala, S.I., Department of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada, Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Drossman, D.A., Center for Functional GI & Motility Disorders, University of North Carolina, Center for Education and Practice of Biopsychosocial Care, and Drossman Gastroenterology, Chapel Hill, NC, United States; Ghoshal, U.C., Department of Gastroenterology, Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI), Lucknow, India; Simren, M., Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden; Tack, J., Translational Research Center for Gastrointestinal Disorders (TARGID), University of Leuven, Leuven, Belgium; Whitehead, W.E., Center for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States; Dumitrascu, D.L., Iuliu Hatieganu University of Medicine and Pharmacy, Cluj-Napoca, Romania; Fang, X., Department of Gastroenterology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Fukudo, S., Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Kellow, J., Discipline of Medicine, Northern Clinical School, University of Sydney, Sydney, Australia; Okeke, E., Department of Medicine, University of Jos, Jos University Teaching Hospital, Jos, Nigeria; Quigley, E.M.M., Lynda K. and David M. Underwood Center for Digestive Disorder, Gastroenterology and Hepatology, Houston Methodist Hospital and Weill Cornell Medical College, Houston, TX, United States; Schmulson, M., Laboratory of Liver, Pancreas and Motility (HIPAM), Unit of Research in Experimental Medicine, Faculty of Medicine, Universidad Nacional Autónoma de Mexico (UNAM). Hospital General de México, Mexico City, Mexico; Whorwell, P., Neurogastroenterology Unit, Manchester University NHS Foundation Trust, Wythenshawe Hospital, Manchester, United Kingdom; Archampong, T., Department of Medicine, University of Ghana School of Medicine and Dentistry, Accra, Ghana; Adibi, P., Integrative Functional Gastroenterology Research Center, Department of Internal Medicine, School of Medicine, Isfahan University of Medical SciencesIsfahan, Iran; Andresen, V., Department of Medicine, Israelitic Hospital, Hamburg, Germany; Benninga, M.A., Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Amsterdam, The Netherlands, Netherlands; Bonaz, B., Service d'Hépato-Gastroentérologie, CHU Grenoble Alpes, Grenoble, France; Bor, S., Ege University School of Medicine, Division of Gastroenterology, Bornova Izmir, Turkey; Fernandez, L.B., “Centro Medico Dr. Bustos Fernandez”, Buenos Aires, Argentina; Choi, S.C., Department of Gastroenterology, School of Medicine, Wonkwang University, Iksan, South Korea; Corazziari, E.S., Department of Gastroenterology, Istituto Clinico Humanitas, Rozzano, Italy; Francisconi, C., Department of Internal Medicine, Universidade Federal do Rio Grande do Sul, Gastroenterology Division, Hospital de Clínicas de Porto Alegre, Porto Alegre, Rio Grande do Sul, Brazil; Hani, A., Gastroenterology Unit, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia; Lazebnik, L., Department of Outpatient Medicine, Faculty of Internal Medicine, Moscow State University of Medicine and Dentistry, Moscow, Russian Federation; Lee, Y.Y., School of Medical Sciences, Universiti Sains Malaysia, Kota Bharu, Kelantan, Malaysia; Mulak, A., Department of Gastroenterology and Hepatology, Wroclaw Medical University, Wroclaw, Poland; Rahman, M.M., Dhaka Medical College & Hospital, Dhaka, Bangladesh; Santos, J., Department of Gastroenterology, University Hospital Vall d'Hebron, Autonomous University of Barcelona & Neuro-Inmuno-Gastroenterology Lab, Vall d'Hebron Research Institute, Barcelona, Spain; Setshedi, M., Department of Medicine, Division of Gastroenterology, University of Cape Town, Cape Town, South Africa; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Vanner, S., Gastrointestinal Diseases Research Unit, Kingston Health Science Centre, Queen's University, Kingston, ON, Canada; Wong, R.K., Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore; Lopez-Colombo, A., UMAE Hospital de Especialidades C.M.N. Manuel Avila Camacho, Puebla Pue, Mexico; Costa, V., Gastroenterology Unit, Hospital Universitario San Ignacio, Pontificia Universidad Javeriana, Bogotá, Colombia; Dickman, R., Division of Gastroenterology, Rabin Medical Center, Sackler School of Medicine, Tel-Aviv, Israel; Kanazawa, M., Department of Behavioral Medicine, Tohoku University Graduate School of Medicine, Sendai, Japan; Keshteli, A.H., CEGIIR-Division of Gastroenterology, Department of Medicine, University of Alberta, Edmonton, AB, Canada; Khatun, R., Population Health Research Institute, McMaster University, Hamilton, ON, Canada; Maleki, I., Gut and Liver Research Center, Department of Internal Medicine, Mazandaran University of Medical Sciences, Sari, Iran; Poitras, P., CHUM, Université de Montréal, Montréal, QC, Canada; Pratap, N., KIMS Hospitals, Secunderabad, India; Stefanyuk, O., Department of Biochemical Markers of Chronic Non-Communicable Diseases Research National Medical Research Centre for Preventive Medicine, Moscow, Russian Federation; Thomson, S., Department of Medicine, Division of Gastroenterology, University of Cape Town, Cape Town, South Africa; Zeevenhooven, J., Emma Children's Hospital, Amsterdam UMC, University of Amsterdam, Pediatric Gastroenterology, Amsterdam, The Netherlands, Netherlands; Palsson, O.S., Center for Functional GI & Motility Disorders, University of North Carolina-Chapel Hill, Chapel Hill, NC, United States |
Background & Aims: Although functional gastrointestinal disorders (FGIDs), now called disorders of gut-brain interaction, have major economic effects on health care systems and adversely affect quality of life, little is known about their global prevalence and distribution. We investigated the prevalence of and factors associated with 22 FGIDs, in 33 countries on 6 continents. Methods: Data were collected via the Internet in 24 countries, personal interviews in 7 countries, and both in 2 countries, using the Rome IV diagnostic questionnaire, Rome III irritable bowel syndrome questions, and 80 items to identify variables associated with FGIDs. Data collection methods differed for Internet and household groups, so data analyses were conducted and reported separately. Results: Among the 73,076 adult respondents (49.5% women), diagnostic criteria were met for at least 1 FGID by 40.3% persons who completed the Internet surveys (95% confidence interval [CI], 39.9–40.7) and 20.7% of persons who completed the household surveys (95% CI, 20.2–21.3). FGIDs were more prevalent among women than men, based on responses to the Internet survey (odds ratio, 1.7; 95% CI, 1.6–1.7) and household survey (odds ratio, 1.3; 95% CI, 1.3–1.4). FGIDs were associated with lower quality of life and more frequent doctor visits. Proportions of subjects with irritable bowel syndrome were lower when the Rome IV criteria were used, compared with the Rome III criteria, in the Internet survey (4.1% vs 10.1%) and household survey (1.5% vs 3.5%). Conclusions: In a large-scale multinational study, we found that more than 40% of persons worldwide have FGIDs, which affect quality of life and health care use. Although the absolute prevalence was higher among Internet respondents, similar trends and relative distributions were found in people who completed Internet vs personal interviews. © 2021 The Authors |
DGBI; epidemiology; IBS |
abdominal pain; adult; anorectal disease; Article; biliary tract pain; comparative study; confidence interval; data analysis; descriptive research; digestive system function disorder; disease burden; duodenum disease; esophagus disease; female; gastrointestinal disease; human; information processing; Internet; irritable colon; Italy; major clinical study; male; prevalence; priority journal; quality of life; questionnaire; Research Diagnostic Criteria; adolescent; age distribution; aged; gastrointestinal disease; global health; middle aged; sex ratio; young adult; Adolescent; Adult; Age Distribution; Aged; Female; Gastrointestinal Diseases; Global Health; Humans; Male; Middle Aged; Prevalence; Sex Distribution; Surveys and Questionnaires; Young Adult |
W.B. Saunders |
00165085 |
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32294476 |
Article |
Q1 |
7828 |
131 |
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915 |
Arozal W., Louisa M., Rahmat D., Chendrana P., Sandhiutami N.M.D. |
32067462200;41461551400;36673726800;57220117465;56692904000; |
Development, characterization and pharmacokinetic profile of chitosan-sodium tripolyphosphate nanoparticles based drug delivery systems for curcumin |
2021 |
Advanced Pharmaceutical Bulletin |
11 |
1 |
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77 |
85 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096977127&doi=10.34172%2fapb.2021.008&partnerID=40&md5=8dc05f691c7524d3d33c6f2b7b701019 |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rahmat, D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Chendrana, P., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia; Sandhiutami, N.M.D., Faculty of Pharmacy, University of Pancasila, Jakarta, Indonesia, Doctoral Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: This study aimed to provide the method of preparation, characterization of curcumin-loaded chitosan-sodium tripolyphosphate (NaTPP) nanoparticle, and evaluate its pharmacokinetic profiles. Methods: Curcumin-loaded chitosan-NaTPP nanoparticles were synthesized using ionic gelation methods. Curcumin was dissolved using surfactants and cosurfactants. Chitosan polymer was then mixed in the curcumin solution and dripped with NaTPP solution until nanoparticle formation. The mucoadhesive study was evaluated by measuring the fluorescence of curcumin within the prepared nanoparticles. The pharmacokinetic profiles of curcumin particles and nanoparticles were then assessed in rats by administering a single oral dose of 100 mg/kg BW. Blood samples were taken from nine predetermined time points, and curcumin plasma concentrations were then analyzed using UPLC-MS/MS. Results: The particle size of the curcumin nanoparticles obtained were 11.5 nm. Entrapment efficiency (EE) of curcumin nanoparticles were exceeding 99.97%, and drug loading capacity (DLC) was 11.34%. The mucoadhesive properties of the nanoparticles were superior to that of curcumin particles. Pharmacokinetic evaluation in rats revealed that curcumin nanoparticles resulted in an increase of area under the curve (AUC), maximum concentration (Cmax), earlier time to reach maximum concentration (Tmax), and lower clearance (CL). Conclusion: Curcumin-loaded chitosan-NaTPP nanoparticles is an effective formulation to improve curcumin plasma concentrations. Thus, enable its applications for the treatment of various diseases. © 2021 The Author(s). |
Chitosan; Curcumin; Mucoadhesive; Nanoparticles; Pharmacokinetics |
chitosan; cosurfactant; curcumin; nanoparticle; polymer; surfactant; tripolyphosphate; animal experiment; animal tissue; area under the curve; Article; blood sampling; controlled study; drug delivery system; female; fluorescence; gelation; human; maximum concentration; mucoadhesion; nonhuman; particle size; pharmacokinetic parameters; plasma concentration-time curve; rat; tandem mass spectrometry; ultra performance liquid chromatography; zeta potential |
Tabriz University of Medical Sciences |
22285881 |
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Article |
Q1 |
773 |
6281 |
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916 |
Coughlin C.R., II, Tseng L.A., Abdenur J.E., Ashmore C., Boemer F., Bok L.A., Boyer M., Buhas D., Clayton P.T., Das A., Dekker H., Evangeliou A., Feillet F., Footitt E.J., Gospe S.M., Jr., Hartmann H., Kara M., Kristensen E., Lee J., Lilje R., Longo N., Lunsing R.J., Mills P., Papadopoulou M.T., Pearl P.L., Piazzon F., Plecko B., Saini A.G., Santra S., Sjarif D.R., Stockler-Ipsiroglu S., Striano P., Van Hove J.L.K., Verhoeven-Duif N.M., Wijburg F.A., Zuberi S.M., van Karnebeek C.D.M. |
57203153211;57193113158;6602690660;55329181300;22133268100;18433647100;56442108100;54415352400;26643542700;7403597535;57072925500;6601972696;6701669931;24066333000;7004867097;19234327400;55964701800;57218823969;57219907275;6507651491;7004663930;7801612204;57202556029;57213632266;7003948257;54950108600;55990557800;37087697200;24172569400;6506242684;55930268500;6701766775;7005706056;35747586800;7003454408;7005936517;6506453512; |
Consensus guidelines for the diagnosis and management of pyridoxine-dependent epilepsy due to α-aminoadipic semialdehyde dehydrogenase deficiency |
2021 |
Journal of Inherited Metabolic Disease |
44 |
1 |
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178 |
192 |
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9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096935873&doi=10.1002%2fjimd.12332&partnerID=40&md5=519c5479b1e22e3b77f1890b9b382e4d |
Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, United States; Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom; Department of Human Genetics, Centre Hospitalier Universitaire Sart-Tilman, Liège, Belgium; Department of Pediatrics and Neonatology, Máxima Medical Center, Veldhoven, Netherlands; Division of Medical Genetics, Department of Specialized Medicine, Montreal Children's Hospital, McGill University Health Centre, Québec, Canada; Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Clinic for Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany; VKS: Dutch Patient Organization for Metabolic Diseases, Zwolle, Netherlands; Division of Child Neurology and Inherited Metabolic Disorders, 4th Department of Pediatrics, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece; Reference Center for Inborn Errors of Metabolism, Pediatric Unit, University Hospital of Nancy, Nancy, France; INSERM UMR S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, University of Lorraine, Nancy, France; Department of Metabolic Paediatrics, Great Ormond Street Hospital, London, United Kingdom; Division of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Washington, Seattle, WA, United States; Department of Pediatrics, Duke University, Durham, NC, United States; Department of Pediatrics, University of Tripoli, Tripoli, Libyan Arab Jamahiriya; National Management of Newborn Screening and Advanced Laboratory Diagnostics in Inborn Errors of Metabolism, Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Department of Metabolic Medicine, The Royal Children's Hospital, Melbourne, VIC, Australia; Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT, United States; Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Neurometabolic Clinic, Children's Institute, University of Sao Paulo, Brazil; Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Biochemical Genetics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada; Pediatric Neurology and Muscular Diseases Unit, IRCCS “G. Gaslini” Institute, Genoa, Italy; Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genoa, Italy; Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands; Paediatric Neurosciences Research Group, Royal Hospital for Children & School of Medicine, University of Glasgow, Glasgow, United Kingdom; Department of Pediatrics, Amalia Children's Hospital, Radboud Centre for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Coughlin, C.R., II, Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Tseng, L.A., Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Abdenur, J.E., Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, United States; Ashmore, C., Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom; Boemer, F., Department of Human Genetics, Centre Hospitalier Universitaire Sart-Tilman, Liège, Belgium; Bok, L.A., Department of Pediatrics and Neonatology, Máxima Medical Center, Veldhoven, Netherlands; Boyer, M., Division of Metabolic Disorders, CHOC Children's Hospital, Orange, CA, United States; Buhas, D., Division of Medical Genetics, Department of Specialized Medicine, Montreal Children's Hospital, McGill University Health Centre, Québec, Canada; Clayton, P.T., Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Das, A., Clinic for Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany; Dekker, H., VKS: Dutch Patient Organization for Metabolic Diseases, Zwolle, Netherlands; Evangeliou, A., Division of Child Neurology and Inherited Metabolic Disorders, 4th Department of Pediatrics, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece; Feillet, F., Reference Center for Inborn Errors of Metabolism, Pediatric Unit, University Hospital of Nancy, Nancy, France, INSERM UMR S 1256, Nutrition, Genetics, and Environmental Risk Exposure (NGERE), Faculty of Medicine of Nancy, University of Lorraine, Nancy, France; Footitt, E.J., Department of Metabolic Paediatrics, Great Ormond Street Hospital, London, United Kingdom; Gospe, S.M., Jr., Division of Pediatric Neurology, Departments of Neurology and Pediatrics, University of Washington, Seattle, WA, United States, Department of Pediatrics, Duke University, Durham, NC, United States; Hartmann, H., Clinic for Paediatric Kidney, Liver, and Metabolic Diseases, Hannover Medical School, Hannover, Germany; Kara, M., Department of Pediatrics, University of Tripoli, Tripoli, Libyan Arab Jamahiriya; Kristensen, E., National Management of Newborn Screening and Advanced Laboratory Diagnostics in Inborn Errors of Metabolism, Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Lee, J., Department of Metabolic Medicine, The Royal Children's Hospital, Melbourne, VIC, Australia; Lilje, R., Department of Children and Adolescent Medicine, Oslo University Hospital, Oslo, Norway; Longo, N., Division of Medical Genetics, Department of Pediatrics, University of Utah, Salt Lake City, UT, United States; Lunsing, R.J., Department of Neurology, University Medical Center Groningen, University of Groningen, Groningen, Netherlands; Mills, P., Genetics and Genomic Medicine, UCL Great Ormond Street Institute of Child Health, London, United Kingdom; Papadopoulou, M.T., Division of Child Neurology and Inherited Metabolic Disorders, 4th Department of Pediatrics, Aristotle University of Thessaloniki, General Hospital Papageorgiou, Thessaloniki, Greece; Pearl, P.L., Division of Epilepsy and Clinical Neurophysiology, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, MA, United States; Piazzon, F., Neurometabolic Clinic, Children's Institute, University of Sao Paulo, Brazil; Plecko, B., Division of General Pediatrics, Department of Pediatrics and Adolescent Medicine, Medical University of Graz, Graz, Austria; Saini, A.G., Pediatric Neurology Unit, Department of Pediatrics, Postgraduate Institute of Medical Education and Research, Chandigarh, India; Santra, S., Birmingham Women's and Children's NHS Foundation Trust, Birmingham, United Kingdom; Sjarif, D.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stockler-Ipsiroglu, S., Division of Biochemical Genetics, BC Children's Hospital, University of British Columbia, Vancouver, BC, Canada; Striano, P., Pediatric Neurology and Muscular Diseases Unit, IRCCS “G. Gaslini” Institute, Genoa, Italy, Department of Neurosciences, Rehabilitation, Ophthalmology, Genetics, Maternal and Child Health, University of Genova, Genoa, Italy; Van Hove, J.L.K., Section of Clinical Genetics and Metabolism, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, United States; Verhoeven-Duif, N.M., Department of Genetics, University Medical Center Utrecht, Utrecht, Netherlands; Wijburg, F.A., Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands; Zuberi, S.M., Paediatric Neurosciences Research Group, Royal Hospital for Children & School of Medicine, University of Glasgow, Glasgow, United Kingdom; van Karnebeek, C.D.M., Department of Pediatrics Emma Children's Hospital, Amsterdam University Medical Centre, Amsterdam, Netherlands, Department of Pediatrics, Amalia Children's Hospital, Radboud Centre for Mitochondrial Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Pyridoxine-dependent epilepsy (PDE-ALDH7A1) is an autosomal recessive condition due to a deficiency of α-aminoadipic semialdehyde dehydrogenase, which is a key enzyme in lysine oxidation. PDE-ALDH7A1 is a developmental and epileptic encephalopathy that was historically and empirically treated with pharmacologic doses of pyridoxine. Despite adequate seizure control, most patients with PDE-ALDH7A1 were reported to have developmental delay and intellectual disability. To improve outcome, a lysine-restricted diet and competitive inhibition of lysine transport through the use of pharmacologic doses of arginine have been recommended as an adjunct therapy. These lysine-reduction therapies have resulted in improved biochemical parameters and cognitive development in many but not all patients. The goal of these consensus guidelines is to re-evaluate and update the two previously published recommendations for diagnosis, treatment, and follow-up of patients with PDE-ALDH7A1. Members of the International PDE Consortium initiated evidence and consensus-based process to review previous recommendations, new research findings, and relevant clinical aspects of PDE-ALDH7A1. The guideline development group included pediatric neurologists, biochemical geneticists, clinical geneticists, laboratory scientists, and metabolic dieticians representing 29 institutions from 16 countries. Consensus guidelines for the diagnosis and management of patients with PDE-ALDH7A1 are provided. © 2020 SSIEM |
ALDH7A1; alpha aminoadipic semialdehyde; consensus guidelines; pyridoxine-dependent epilepsy; pyridoxine-responsive seizures |
aminoadipate semialdehyde dehydrogenase; arginine; pipecolic acid; pyridoxine; aldehyde dehydrogenase; arginine; lysine; pyridoxine; ALDH7A1 gene; apnea; Article; autosomal recessive disorder; coma; developmental delay; developmental screening; diet restriction; diet supplementation; epilepsy; gene; gene mutation; genetic screening; heterozygote detection; homocystinuria; human; hyperargininemia; incidence; infantile spasm; intellectual impairment; lumbar puncture; lysine restricted diet; MELAS syndrome; peripheral neuropathy; prenatal diagnosis; protein restriction; pyridoxine dependent epilepsy; recommended drug dose; sensory neuropathy; urea cycle disorder; consensus; dietary supplement; epilepsy; international cooperation; practice guideline; Aldehyde Dehydrogenase; Arginine; Consensus |
John Wiley and Sons Inc |
01418955 |
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33200442 |
Article |
Q1 |
1462 |
2367 |
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918 |
Ramani S., McKimm J., Findyartini A., Nadarajah V.D., Hays R., Chisolm M.S., Filipe H.P., Fornari A., Kachur E.K., Kusurkar R.A., Thampy H., Wilson K.W. |
56186462600;26433565200;56543777300;14048599600;7202509928;25957566100;36657108400;6701517660;6603938626;6603461994;55349958700;56926010000; |
Twelve tips for developing a global community of scholars in health professions education |
2021 |
Medical Teacher |
43 |
8 |
|
966 |
971 |
|
3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85094560355&doi=10.1080%2f0142159X.2020.1839034&partnerID=40&md5=5cfe14caf9b8e1e02d7e63fd250a2375 |
Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; Swansea University Medical School, United Kingdom; Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; International Medical University, Kuala Lumpur, Malaysia; James Cook University, Townesville, QLD, Australia; Johns Hopkins University School of Medicine, Baltimore, MD, United States; University of Lisbon, Lisbon, Portugal; Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States; Medical Education Development, Global Consulting, New York, NY, United States; Faculty of Medicine, Vrije Universiteit Amsterdam, Netherlands; Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Dalhousie University, Halifax, NS, Canada |
Ramani, S., Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, United States; McKimm, J., Swansea University Medical School, United Kingdom; Findyartini, A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nadarajah, V.D., International Medical University, Kuala Lumpur, Malaysia; Hays, R., James Cook University, Townesville, QLD, Australia; Chisolm, M.S., Johns Hopkins University School of Medicine, Baltimore, MD, United States; Filipe, H.P., University of Lisbon, Lisbon, Portugal; Fornari, A., Donald and Barbara Zucker SOM at Hofstra/Northwell, Hempstead, NY, United States; Kachur, E.K., Medical Education Development, Global Consulting, New York, NY, United States; Kusurkar, R.A., Faculty of Medicine, Vrije Universiteit Amsterdam, Netherlands; Thampy, H., Faculty of Biology, Medicine and Health, University of Manchester, Manchester, United Kingdom; Wilson, K.W., Dalhousie University, Halifax, NS, Canada |
Scholarship in Health Professions Education is not just original research, it also includes study of educational processes, and application of new knowledge to practice. The pathways to successful scholarship are not always clear to novice educators. In this article, we describe strategies to establish a Community of Scholars (CoS), where more experienced and senior members guide junior members in scholarship to advance the field. Drawing on Lave and Wenger’s concepts of Communities of Practice (CoP), we describe twelve practical tips, which include generation of a shared vision, formation of a global community of scholars, engagement in scholarly initiatives, and development of a professional identity, categorised under three major steps: establish, grow, and sustain the community. The tips embrace inclusivity for diverse cultural contexts which further provide opportunities for Health Professions Educators, interested in forming communities of practice, to work on scholarly outputs and add value to the professional arena. © 2020 Informa UK Limited, trading as Taylor & Francis Group. |
continuing; Leadership; mentoring; staff development |
article; drawing; human; human experiment; leadership; mentoring; occupation; personnel management; vision; medical education; medical profession; Fellowships and Scholarships; Health Occupations; Humans |
Taylor and Francis Ltd. |
0142159X |
|
33108740 |
Article |
Q1 |
1355 |
2689 |
|
|
922 |
Aman A.T., Wibawa T., Kosasih H., Asdie R.H., Safitri I., Intansari U.S., Mawarti Y., Sudarmono P., Arif M., Puspitasari D., Alisjahbana B., Parwati K.T.M., Gasem M.H., Lokida D., Lukman N., Hartono T.S., Mardian Y., Liang C.J., Siddiqui S., Karyana M., Lau C.-Y. |
6701594071;6507271804;6507043017;23494913500;26647011700;55326687600;57194392139;6507855437;56740206600;37001098000;6506944516;57211545843;6508371601;57190663838;57190737414;57210165041;57196189278;57201642191;8707129300;24449083500;16245242000; |
Etiologies of severe acute respiratory infection (SARI) and misdiagnosis of influenza in Indonesia, 2013-2016 |
2021 |
Influenza and other Respiratory Viruses |
15 |
1 |
|
34 |
44 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087868865&doi=10.1111%2firv.12781&partnerID=40&md5=d277f265cec13ab0a49fac5153d6d8ed |
Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Hasanudin / Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; Dr. Soetomo Academic General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Faculty of Medicine, Universitas Padjadjaran / Dr. Hasan Sadikin Hospital, Sumedang, Indonesia; Medical Faculty, Udayana University and Sanglah General Hospital, Denpasar, Indonesia; Dr. Kariadi Hospital / Diponegoro University, Semarang, Indonesia; Tangerang District Hospital, Tangerang, Indonesia; Sulianti Saroso Hospital, Jakarta, Indonesia; National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States; National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia |
Aman, A.T., Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia, Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Wibawa, T., Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia, Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Kosasih, H., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Asdie, R.H., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Department of Internal Medicine, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Safitri, I., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Department of Pediatric, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Intansari, U.S., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Department of Clinical Pathology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia; Mawarti, Y., Department of Microbiology, Faculty of Medicine, Public Health, and Nursing, Universitas Gadjah Mada / Dr. Sardjito Hospital, Yogyakarta, Indonesia, Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Sudarmono, P., Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arif, M., Faculty of Medicine, Universitas Hasanudin / Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; Puspitasari, D., Dr. Soetomo Academic General Hospital, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Alisjahbana, B., Faculty of Medicine, Universitas Padjadjaran / Dr. Hasan Sadikin Hospital, Sumedang, Indonesia; Parwati, K.T.M., Medical Faculty, Udayana University and Sanglah General Hospital, Denpasar, Indonesia; Gasem, M.H., Dr. Kariadi Hospital / Diponegoro University, Semarang, Indonesia; Lokida, D., Tangerang District Hospital, Tangerang, Indonesia; Lukman, N., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Hartono, T.S., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, Sulianti Saroso Hospital, Jakarta, Indonesia; Mardian, Y., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia; Liang, C.J., National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States; Siddiqui, S., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States; Karyana, M., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, National Institute of Health Research and Development (NIHRD), Ministry of Health, Jakarta, Indonesia; Lau, C.-Y., Indonesia Research Partnership on Infectious Diseases (INA-RESPOND), Jakarta, Indonesia, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD, United States |
Background: Severe acute respiratory infection (SARI) accounts for a large burden of illness in Indonesia. However, epidemiology of SARI in tertiary hospitals in Indonesia is unknown. This study sought to assess the burden, clinical characteristics, and etiologies of SARI and concordance of clinical diagnosis with confirmed etiology. Methods: Data and samples were collected from subjects presenting with SARI as part of the acute febrile Illness requiring hospitalization study (AFIRE). In tertiary hospitals, clinical diagnosis was ascertained from chart review. Samples were analyzed to determine the “true” etiology of SARI at hospitals and Indonesia Research Partnership on Infectious Diseases (INA-RESPOND) laboratory. Distribution and characteristics of SARI by true etiology and accuracy of clinical diagnosis were assessed. Results: Four hundred and twenty of 1464 AFIRE subjects presented with SARI; etiology was identified in 242 (57.6%), including 121 (28.8%) viruses and bacteria associated with systemic infections, 70 (16.7%) respiratory bacteria and viruses other than influenza virus, and 51 (12.1%) influenza virus cases. None of these influenza patients were accurately diagnosed as having influenza during hospitalization. Conclusions: Influenza was misdiagnosed among all patients presenting with SARI to Indonesian tertiary hospitals in the AFIRE study. Diagnostic approaches and empiric management should be guided by known epidemiology. Public health strategies to address the high burden of influenza should include broad implementation of SARI screening, vaccination programs, clinician education and awareness campaigns, improved diagnostic capacity, and support for effective point-of-care tests. © 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd. |
diagnostic accuracy; etiology; Indonesia; influenza; severe acute respiratory infection |
adolescent; adult; Article; child; demography; diagnostic accuracy; diagnostic error; disease burden; female; hospitalization; human; Indonesia; influenza; information processing; major clinical study; male; measurement accuracy; medical record review; middle aged; priority journal; severe acute respiratory syndrome; tertiary care center; diagnostic error; infant; influenza; Orthomyxoviridae; respiratory tract infection; Diagnostic Errors; Hospitalization; Humans; Indonesia; Infant; Influenza, Human; Orthomyxoviridae; Respiratory Tract Infections |
Blackwell Publishing Ltd |
17502640 |
|
32666619 |
Article |
Q1 |
1743 |
1724 |
|
|
923 |
Hidayati E.L., Utami M.D., Rohsiswatmo R., Tridjaja B. |
57200542624;57217291921;55533574600;6504507193; |
Cystatin C compared to serum creatinine as a marker of acute kidney injury in critically ill neonates |
2021 |
Pediatric Nephrology |
36 |
1 |
|
181 |
186 |
|
3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087002032&doi=10.1007%2fs00467-020-04668-3&partnerID=40&md5=45ca525dfa7a5bd6f6f0c1d995fe7930 |
Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Hidayati, E.L., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Utami, M.D., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Rohsiswatmo, R., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Tridjaja, B., Department of Child Health, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is one of the most common causes of neonatal morbidity and mortality. Diagnosing AKI in neonates is challenging as it lacks specific signs, symptoms, and biomarkers. However, detecting AKI in critically ill neonates is crucial to determine appropriate management and prevent complications. Cystatin C (CysC) has been recognized as a superior kidney biomarker reflecting kidney function in neonates. The objective of this study is to evaluate the diagnostic value of CysC as an AKI biomarker in critically ill neonates. Methods: We performed a diagnostic test between cystatin C-based estimated glomerular filtration rate (eGFR-CysC) and serum creatinine-based estimated glomerular filtration rate (eGFR-SCr) as the gold standard to diagnose AKI in 135 critically ill neonates treated in Cipto Mangunkusumo National Hospital from July 2017 to January 2018. Results: Prevalence of AKI was 23.7% predominantly in neonates with a very preterm gestational age, low birthweight, probable sepsis, and those receiving invasive oxygen therapy or nephrotoxic drugs. The proportion of AKI based on neonate RIFLE criteria was 72.7% risk, 18.9% injury, and 9% failure. eGFR-CysC had the following parameters: sensitivity, 84.8%; specificity, 61.8%; PPV, 41.8%; NPV, 89.7%; LR(+), 2.2; LR(−), 0.24; and accuracy, 67.4%. The AUROC for CysC was 84.9%. The optimal cut-off value for CysC was 1.605 mg/l. Conclusions: CysC may be used as a screening biomarker of AKI in critically ill neonates; yet, it was not superior to serum creatinine. [Figure not available: see fulltext.]. © 2020, IPNA. |
Acute kidney injury; Critically ill neonates; Cystatin C; Serum creatinine |
creatinine; cystatin C; biological marker; creatinine; cystatin C; epidermal growth factor receptor; acute kidney failure; area under the curve; Article; controlled study; creatinine blood level; critically ill patient; diagnostic accuracy; diagnostic test; diagnostic test accuracy study; diagnostic value; estimated glomerular filtration rate; extremely low birth weight; female; gestational age; human; low birth weight; major clinical study; male; negative likelihood ratio; newborn; oxygen therapy; positive likelihood ratio; predictive value; prematurity; prevalence; priority journal; receiver operating characteristic; sensitivity and specificity; sepsis; very low birth weight; acute kidney failure; critical illness; prospective study; Acute Kidney Injury; Biomarkers; Creatinine; Critical |
Springer Science and Business Media Deutschland GmbH |
0931041X |
|
32594242 |
Article |
Q1 |
831 |
5739 |
|
|
925 |
Surja S.S., Adawiyah R., Houbraken J., Rozaliyani A., Sjam R., Yunihastuti E., Wahyuningsih R. |
57209258108;57208658742;12770401000;57203065912;23398458200;57221273925;6507268400; |
Talaromyces atroroseus in HIV and non-HIV patient: A first report from Indonesia |
2021 |
Medical Mycology |
58 |
4 |
|
560 |
563 |
|
3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085715396&doi=10.1093%2fMMY%2fMYZ090&partnerID=40&md5=9fec23d3506804c0bc622f42e14314ff |
Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Westerdijk Fungal Biodiversity Institute, Netherlands; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
Surja, S.S., Master Program in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, School of Medicine and Health Sciences, Universitas Katolik Indonesia, Atma Jaya, Indonesia; Adawiyah, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Houbraken, J., Westerdijk Fungal Biodiversity Institute, Netherlands; Rozaliyani, A., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Sjam, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia; Yunihastuti, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia; Wahyuningsih, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Kristen Indonesia, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Indonesia |
We performed morphology, molecular study and antifungal susceptibility test on 10 Talaromyces sp. isolates: eight clinical isolates (human immunodeficiency virus (HIV) and non-HIV-patient) and two isolates from rats. All strains produced red soluble pigment and microscopically showed Penicillium-like structure in room temperature and yeast-like structure in 37â—¦C. Based on molecular analysis, nine isolates were identified as Talaromyces atroroseus (including the isolates from rats) and one as T. marneffei. Our susceptibility result of T. marneffei supports the use of amphotericin B, itraconazole for talaromycosis marneffei management. Talaromyces atroroseus showed variable MIC to echinocandin, azole derivatives, 5-flucytosine and amphotericin B. © The Author(s) 2019. |
BenA; Indonesia; ITS; Talaromyces atroroseus; Talaromyces marneffei |
amphotericin B; anidulafungin; caspofungin; echinocandin; fluconazole; flucytosine; itraconazole; micafungin; posaconazole; pyrrole derivative; voriconazole; antifungal agent; antifungal susceptibility; Article; fungus isolation; human; Human immunodeficiency virus infected patient; Indonesia; mycosis; nonhuman; room temperature; Talaromyces; Talaromyces atroroseus; Talaromyces marneffei; talaromycosis; animal; classification; drug effect; genetics; Human immunodeficiency virus infection; Indonesia; isolation and purification; microbial sensitivity test; microbiology; pigmentation; rat; Talaromyces; Animals; Antifungal Agents; HIV Infections; Humans; Indonesia; Microbial Sensitivity Tests; Mycoses; Pigmentation; Rats; Talaromyces |
Oxford University Press |
13693786 |
|
31504774 |
Article |
Q1 |
1004 |
4362 |
|
|