No records
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304 |
Gunawan S., Aulia A., Soetikno V. |
57226331078;57201441066;36769252100; |
Development of rat metabolic syndrome models: A review |
2021 |
Veterinary World |
14 |
7 |
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1774 |
1783 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111179239&doi=10.14202%2fvetworld.2021.1774-1783&partnerID=40&md5=609e64dbfe9d6c9660d991f611abbd71 |
Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia; Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunawan, S., Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia, Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aulia, A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. © 2021 Veterinary World. All rights reserved. |
High-fat diet; High-fructose diet; High-sucrose diet; Metabolic syndrome; Rat models |
cholesterol; diacylglycerol; glucose; high density lipoprotein cholesterol; leptin receptor; low density lipoprotein cholesterol; triacylglycerol; abdominal circumference; abdominal obesity; animal model; bipolar disorder; body weight; bone metabolism; caloric intake; carbohydrate intake; cardiovascular disease; diastolic blood pressure; dyslipidemia; exercise; fat mass; food intake; gene; glucose blood level; glucose tolerance; high-fructose diet; human; hyperglycemia; insulin resistance; insulin sensitivity; insulin tolerance test; lipid diet; lipid metabolism; lipid storage; lipogenesis; major depression; male; mental disease; metabolic syndrome X; nonalcoholic fatty liver; nonhuman; osmotic stress; oxidative stress; pathogenesis; physical activity; prevalence; rat; Review; risk factor; |
Veterinary World |
09728988 |
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Review |
Q2 |
550 |
9187 |
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315 |
Purnomo G.A., Mitchell K.J., O’connor S., Kealy S., Taufik L., Schiller S., Rohrlach A., Cooper A., Llamas B., Sudoyo H., Teixeira J.C., Tobler R. |
56262110300;55937278100;57192065848;57016654100;57225108034;57225091129;56674549200;57225849511;8695218700;6603548824;56290678400;55780763900; |
Mitogenomes reveal two major influxes of papuan ancestry across wallacea following the last glacial maximum and austronesian contact |
2021 |
Genes |
12 |
7 |
965 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109185551&doi=10.3390%2fgenes12070965&partnerID=40&md5=046fa96fdfa7683fb4a23714ea942197 |
Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia; Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia; Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia; ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia; Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia; Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, Germany; Blue Sky Genetics, P.O. Box 287, Adelaide, 5137, Australia; South Australian Museum, Adelaide, 5000, Australia; Environment Institute, University of Adelaide, Adelaide, 5005, Australia; National Centre for Indigenous Genomics, Australian National University, Canberra, 2601, Australia; Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Sydney Medical School, University of Sydney, Sydney, 2050, Australia |
Purnomo, G.A., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; Mitchell, K.J., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia; O’connor, S., Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia; Kealy, S., Archaeology and Natural History, School of Culture, History and Language, College of Asia and the Pacific, Australian National University, Canberra, 2601, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, Australian National University, Canberra, 2601, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; Taufik, L., Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia; Schiller, S., ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia; Rohrlach, A., ARC Centre of Excellence for Mathematical and Statistical Frontiers, School of Mathematical Sciences, The University of Adelaide, Adelaide, 5005, Australia, Department of Archaeogenetics, Max Planck Institute for the Science of Human History, Jena, 07745, Germany; Cooper, A., Blue Sky Genetics, P.O. Box 287, Adelaide, 5137, Australia, South Australian Museum, Adelaide, 5000, Australia; Llamas, B., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Environment Institute, University of Adelaide, Adelaide, 5005, Australia, National Centre for Indigenous Genomics, Australian National University, Canberra, 2601, Australia; Sudoyo, H., Genome Diversity and Diseases Laboratory, Eijkman Institute of Molecular Biology, Jakarta, 10430, Indonesia, Department of Medical Biology, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia, Sydney Medical School, University of Sydney, Sydney, 2050, Australia; Teixeira, J.C., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia; Tobler, R., Australian Centre for Ancient DNA, School of Biological Sciences, University of Adelaide, Adelaide, 5005, Australia, ARC Centre of Excellence for Australian Biodiversity and Heritage, University of Adelaide, Adelaide, 5005, Australia, Evolution of Cultural Diversity Initiative, Australian National University, Canberra, 2601, Australia |
The tropical archipelago of Wallacea contains thousands of individual islands interspersed between mainland Asia and Near Oceania, and marks the location of a series of ancient oceanic voyages leading to the peopling of Sahul—i.e., the former continent that joined Australia and New Guinea at a time of lowered sea level—by 50,000 years ago. Despite the apparent deep antiquity of human presence in Wallacea, prior population history research in this region has been hampered by patchy archaeological and genetic records and is largely concentrated upon more recent history that follows the arrival of Austronesian seafarers ~3000–4000 years ago (3–4 ka). To shed light on the deeper history of Wallacea and its connections with New Guinea and Australia, we performed phylogeographic analyses on 656 whole mitogenomes from these three regions, including 186 new samples from eight Wallacean islands and three West Papuan populations. Our results point to a surprisingly dynamic population history in Wallacea, marked by two periods of extensive demographic change concentrated around the Last Glacial Maximum ~15 ka and post-Austronesian contact ~3 ka. These changes appear to have greatly diminished genetic signals informative about the original peopling of Sahul, and have important implications for our current understanding of the population history of the region. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Human migrations; Mitochondria; MtDNA; Phylogeography; Sahul |
mitochondrial DNA; ancestry group; Article; Asia; Australia; Austronesian people; biogeographic region; gene sequence; haplotype; human; last glacial maximum; migration; mitochondrial genome; Papua New Guinea; Philippines; phylogeny; phylogeography; polymerase chain reaction; population size; population structure; sailor; sequence alignment; simulation; Wallacea; animal; archeology; beetle; female; genetics; history; male; mitochondrial genome; Pacific islands; phylogeny; phylogeography; population genetics; Animals; Archaeology; Asia; Australia; Coleoptera; Female; Genetics, Population; Genome, Mitochondrial; Haplotypes; History, Ancient; Humans; Male; New Guinea; Oceania; Phylogeny; Phylogeography |
MDPI |
20734425 |
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34202821 |
Article |
Q2 |
1337 |
2737 |
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321 |
Kalaij A.G.I., Sugiyanto M., Ilham A.F. |
57223906853;57223907058;57223916865; |
Factors Associated With Vaccination Compliance in Southeast Asian Children: A Systematic Review |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
|
479 |
488 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106426931&doi=10.1177%2f10105395211014640&partnerID=40&md5=5913c1adcdd2be2c2d07170aba4e2029 |
Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kalaij, A.G.I., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiyanto, M., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ilham, A.F., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Although vaccination coverage has reached a peak of 86% globally, around 19.9 million infants and children are yet to receive routine vaccinations—with Asia holding the highest prevalence of noncompliance. This implies notable gaps in vaccination coverage among some regions in the world. This study aims to analyze the factors associated with compliance toward childhood vaccination in Southeast Asia. A systematic review of observational studies was conducted using the following databases: PubMed, Scopus, and Cochrane. Included studies analyze factors affecting compliance with childhood vaccination in Southeast Asia, and assessed with Joanna Briggs Institute (JBI) and Newcastle-Ottawa Scale’s criteria. Sixteen observational studies were included, with a total of 41 956 subjects, consisting of 15 cross-sectional studies and one case-control study. Our results suggested that parental personal–related, children and family status–related, socioeconomic, and health care–related factors strongly affected subjects’ compliance with immunization. Prominent determinants were older maternal age, higher economics groups, parents in government or health care sectors, and frequent antenatal care visits. On the other hand, noncompliance were associated with younger age, large quantity of family members, lower economic groups, lower education, and unemployed parents. We hope that this comprehensive assessment thoroughly addresses challenges and inform strategies to raise compliance toward childhood vaccination in Southeast Asia. © 2021 APJPH. |
childhood vaccination; compliance; factors; Southeast Asia |
case control study; child; childhood; controlled study; cross-sectional study; education; educational status; female; government; health care cost; human; human experiment; infant; male; maternal age; Medline; Newcastle-Ottawa scale; observational study; prenatal care; review; Scopus; Southeast Asia; Southeast Asian; systematic review; unemployment; vaccination; article |
SAGE Publications Inc. |
10105395 |
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34013786 |
Review |
Q2 |
572 |
8837 |
|
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322 |
Fuady A., Khoe L.C., Azzahra T.B., Lestari H.M., Sutanto R.L., Yo E.C., Suryoadji K.A., Sudarsono N.C., Findyartini A. |
37085331400;56586245200;57223601523;57223631169;57222060277;57213188908;57223633894;57201862518;56543777300; |
Good Knowledge but Poor Practice Toward COVID-19 Among Indonesian Youth |
2021 |
Asia-Pacific Journal of Public Health |
33 |
5 |
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605 |
607 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105912511&doi=10.1177%2f10105395211015048&partnerID=40&md5=eeb26dde9d980d4470234af3a533b0c1 |
Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Undergraduate Medical Program, Faculty of Medicine, Indonesia; Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Department of Medical Education, Faculty of Medicine, Indonesia |
Fuady, A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Azzahra, T.B., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Lestari, H.M., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sutanto, R.L., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Yo, E.C., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Suryoadji, K.A., Undergraduate Medical Program, Faculty of Medicine, Indonesia, Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia; Sudarsono, N.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Center for Sports and Exercise Studies, Indonesia Medical Education and Research Institute (IMERI), Faculty of Medicine Universitas Indonesia, Indonesia; Findyartini, A., Medical Education Center, Indonesia Medical Education Research Institute (IMERI), Faculty of Medicine, Universitas Indonesia, Indonesia, Department of Medical Education, Faculty of Medicine, Indonesia |
[No abstract available] |
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SAGE Publications Inc. |
10105395 |
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33998316 |
Article |
Q2 |
572 |
8837 |
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327 |
Pranata R., Vania A., Vania R., Victor A.A. |
57201973901;57215722420;57208328436;57191055282; |
Intravitreal ranibizumab versus dexamethasone implant in macular edema due to branch retinal vein occlusion: Systematic review and meta-analysis |
2021 |
European Journal of Ophthalmology |
31 |
4 |
|
1907 |
1914 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85089198137&doi=10.1177%2f1120672120947595&partnerID=40&md5=2317b4b6003baf17ce61244daa301bb4 |
Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Universitas Kristen Krida WacanaWest Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, National General Hospital, Jakarta, Daerah Istimewa Jakarta, Indonesia |
Pranata, R., Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Vania, A., Universitas Kristen Krida WacanaWest Jakarta, Indonesia; Vania, R., Universitas Pelita Harapan, Tangerang, Banten, Indonesia; Victor, A.A., Department of Ophthalmology, Faculty of Medicine, Universitas Indonesia, National General Hospital, Jakarta, Daerah Istimewa Jakarta, Indonesia |
Purpose: Intravitreal ranibizumab (RNB) and dexamethasone intravitreal implant (DII) were developed in the recent past and has been widely used for macular edema secondary to BRVO. We aimed to assess the efficacy and safety of intravitreal ranibizumab (RNB) compared to dexamethasone intravitreal implant (DII) in patients with macular edema secondary to branch retinal vein occlusion (BRVO). Methods: We performed a comprehensive search on topics that assess RNB and DII in patients with macular edema secondary to BRVO from several electronic databases. Results: There were 678 subjects from five studies. Ranibizumab was associated with a greater increase in best-corrected visual acuity (BCVA; mean difference 9.13, I2: 0%) compared to DII. Ranibizumab also demonstrated a greater ⩾10 (OR 2.76, I2: 0%) and ⩾15 letters (OR 2.78, I2: 0%) gain. RNB has better BCVA (logMAR scale) improvement at 6 months’ follow up (mean difference −0.15, I2: 64%) in favor of RNB. Higher IOP was found in DII group on follow-up (mean difference −2.92, I2: 89%) and RNB has lesser IOP ⩾10 mmHg increase compared to DII (OR 0.08, I2: 0%). Cataract formation and/or progression was less in RNB (OR 0.53, I2: 75%). The need for rescue laser was similar the two groups. Conclusion: Intravitreal RNB was more effective with less pronounced effect on IOP and cataract formation and/or progression compared to DII for patients with macular edema secondary to BRVO. © The Author(s) 2020. |
branch retinal vein occlusion; dexamethasone; Intravitreal; macular edema; ranibizumab |
dexamethasone; ranibizumab; angiogenesis inhibitor; dexamethasone; glucocorticoid; ranibizumab; Article; best corrected visual acuity; branch retinal vein occlusion; cataract extraction; central retinal thickness; comparative effectiveness; controlled study; cost effectiveness analysis; disease exacerbation; drug safety; Early Treatment Diabetic Retinopathy Study; follow up; human; intervention study; intraocular pressure; macular edema; meta analysis; qualitative analysis; quality control; randomized controlled trial (topic); retina vein occlusion; retinal thickness; sensitivity analysis; systematic review; visual acuity; complication; intravitreal drug administration; macular edema; retina vein occlusion; treatment outcome; Angiogenesis Inhibitors; Dexamethasone; Glucocorticoids; Humans; |
SAGE Publications Ltd |
11206721 |
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32757629 |
Article |
Q2 |
790 |
6120 |
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328 |
Sihotang R.C., Alvonico T., Taher A., Birowo P., Rasyid N., Atmoko W. |
57216755881;57216743520;7005269743;6504153311;56245069300;57193125664; |
Premature ejaculation in patients with lower urinary tract symptoms: a systematic review |
2021 |
International Journal of Impotence Research |
33 |
5 |
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516 |
524 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85084492871&doi=10.1038%2fs41443-020-0298-5&partnerID=40&md5=243ef2c5fa8e96c70ec2e3eb9ca5b534 |
Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Sihotang, R.C., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Alvonico, T., Faculty of Medicine, Universitas Indonesia, No. 6, Salemba Raya Road, DKI Jakarta, 10430, Indonesia; Taher, A., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Birowo, P., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Rasyid, N., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia; Atmoko, W., Department of Urology, Cipto Mangunkusumo National Hospital, Diponegoro Road, DKI Jakarta, 10430, Indonesia |
Lower urinary tract symptoms (LUTS) refer to a group of symptoms related to bladder, prostate, and urethra. LUTS are common in men and the severity increases with age. LUTS are frequently associated with sexual dysfunction, such as premature ejaculation (PE), standing as the most common sexual dysfunction in men. Both LUTS and PE cause distress and dissatisfaction for the patient and his partner. This systematic review aims to determine the relationship between LUTS and PE in men. Two reviewers independently conduct a literature search in five online databases (PubMed, Scopus, Proquest, ClinicalKey, and ScienceDirect). In addition, reviewers also reviewed the reference list of chosen articles to identify additional relevant studies. Twelve articles were included in this systematic review that consists of one cohort study and 11 cross-sectional studies. The total scores of each identified study ranged from “poor” to “good.” The prevalence of PE in LUTS ranged from 12 to 77%. Most of the studies showed a significant relationship between LUTS and PE. PE is more common in older age with the peak prevalence in age of 60–69 years old. There is a possible association between PE and LUTS. Further research using cohort or case-control study design on this topic is needed. © 2020, The Author(s), under exclusive licence to Springer Nature Limited. |
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age; human; International Prostate Symptom Score; male; outcome assessment; premature ejaculation; prevalence; prostatectomy; Review; systematic review; urinary tract infection; aged; case control study; cohort analysis; complication; cross-sectional study; ejaculation; lower urinary tract symptom; middle aged; premature ejaculation; Aged; Case-Control Studies; Cohort Studies; Cross-Sectional Studies; Ejaculation; Humans; Lower Urinary Tract Symptoms; Male; Middle Aged; Premature Ejaculation |
Springer Nature |
09559930 |
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32393845 |
Review |
Q2 |
508 |
9947 |
|
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338 |
SITOHANG I.B.S., SOEBARYO R.W., KANOKO M. |
56734569200;6506868173;6507911148; |
Acne lesion extraction versus oral doxycycline for moderate acne vulgaris: A randomized clinical trial |
2021 |
Journal of Clinical and Aesthetic Dermatology |
14 |
6 |
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E61 |
E65 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113565099&partnerID=40&md5=84d3ad669270477356a8236dc4266b13 |
Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
SITOHANG, I.B.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; SOEBARYO, R.W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; KANOKO, M., Department of Pathological Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Acne vulgaris is a polymorphic skin condition comprising inflamed and noninflamed lesions. In addition to topical retinoids, systemic antibiotics play a role as a main therapy for acne with inflamed papules and cysts. However, due to the increasing tendency for bacterial resistance, alternatives to antibiotics are needed. OBJECTIVE: The aim of this study was to evaluate the effectiveness of acne lesion extraction compared to oral doxycycline for moderate acne vulgaris and to explore the impact of both treatments on Hypoxia-inducible factor (HIF)-1 alpha. METHODS: This randomized clinical trial was conducted in two teaching hospitals in 2016. Subjects with moderate acne vulgaris (N=140) were divided into two groups. Each subject in both groups received 0.05% tretinoin cream, applied to the entire face each night, and 2.5% benzoyl peroxide gel, applied to the acne lesions in the morning and afternoon. One group was also treated with oral doxycycline 100mg once daily and the other was treated with acne lesion extraction performed on all facial lesions every two weeks; the patients were evaluated via patient-reported self-assessment and lesion counts every two weeks for six weeks. HIF-1 alpha expression of the biopsied lessions was examined via immunohistochemistry. RESULTS: 128 subjects completed the study. Among these 128 subjects there was a prominent decrease in inflamed lesions at Week 6 in the lesion extraction group compared to the oral doxycycline group (p<0.05). HIF-1 alpha expression of the biopsied lesions was found in 7 of 9 samples taken from the oral doxycycline group, while 3 of 4 samples in the lesion extraction group were found negative. CONCLUSION: According to our results, acne lesion extraction appeared to be more effective than oral doxycycline in treating this sample of patients with moderate acne vulgaris. Additionally, HIF-1 alpha expression appeared to be decreased after acne lesion extraction. © 2021 Matrix Medical Communications. All rights reserved. |
Acne lesion extraction; Hypoxia-inducible factor-1 alpha; Moderate acne vulgaris; Oral doxycycline |
benzoyl peroxide; doxycycline; hypoxia inducible factor 1alpha; retinoic acid; acne vulgaris; adult; Article; clinical evaluation; comparative effectiveness; controlled study; disease severity; extraction; face; female; histopathology; human; human tissue; immunohistochemistry; major clinical study; male; night; protein expression; randomized controlled trial; self evaluation |
Matrix Medical Communications |
19412789 |
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Article |
Q2 |
600 |
8425 |
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341 |
Rustamadji P., Wiyarta E., Bethania K.A., Kusmardi K. |
55321572200;57221521342;57226320454;56966625300; |
Potential of AKT2 expression as a predictor of lymph-node metastasis in invasive breast carcinoma of no special type |
2021 |
Journal of Pathology and Translational Medicine |
51 |
3 |
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271 |
278 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111106383&doi=10.4132%2fjptm.2021.04.26&partnerID=40&md5=25c257f935b27c34728f8cc05fdeca15 |
Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rustamadji, P., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bethania, K.A., Department of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Invasive breast carcinoma of no special type (IBC-NST) is the most common type of breast cancer and mainly causes regional lymph-node metastasis (LNM). We investigated the potential for AKT2 expression as a predictive biomarker for LNM in IBC-NST. Methods: Forty-eight paraffin blocks containing IBC-NST primary tumors were divided into two groups based on presence or absence of LNM. Age, tumor grade, tumor size, lymphovascular invasion (LVI), and AKT expression were assessed. AKT2 expression was assessed based on immunohistochemical staining, while other data were collected from archives. Results: Multiple logistic regression results showed that AKT2 expression and LVI were significantly associated with LNM (odds ratio [OR], 5.32; 95% confidence interval [CI], 1.42 to 19.93 and OR, 4.46; 95% CI, 1.17 to 16.97, respectively). AKT2 expression was able to discriminate against LNM (area under the receiver operating characteristic, 0.799 ± 0.063; 95% CI, 0.676 to 0.921) at an H-score cutoff of 104.62 (83.3% sensitivity, 62.5% specificity). Conclusions: AKT2 expression has potential as a predictor of LNM in IBC-NST. The H-score cutoff for AKT2 expression can be used as a classification guide in future studies. © 2021 The Korean Society of Pathologists/The Korean Society for Cytopathology. |
AKT2; Breast neoplasms; Immunohistochemistry; Metastasis |
biological marker; protein kinase B beta; adult; aged; Article; breast carcinoma; cancer grading; clinical article; confidence interval; controlled study; female; human; human tissue; immunohistochemistry; lymph vessel metastasis; multivariate logistic regression analysis; odds ratio; predictive value; protein expression; receiver operating characteristic; sensitivity and specificity; tumor invasion; tumor volume |
Seoul National University |
23837837 |
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Article |
Q2 |
684 |
7312 |
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349 |
Shukla A., Shreshtha A., Mukund A., Bihari C., Eapen C.E., Han G., Deshmukh H., Cua I.H.Y., Lesmana C.R.A., Al Meshtab M., Kage M., Chaiteeraki R., Treeprasertsuk S., Giri S., Punamiya S., Paradis V., Qi X., Sugawara Y., Abbas Z., Sarin S.K. |
36652088000;57225888142;15071187800;49860931800;7003684081;24741087200;7003527959;7801457234;8977683000;57225918379;57225886245;57225920095;57077082800;57221051314;23670642900;57195572516;35339923000;57197741618;35572268700;57220191468; |
Budd-Chiari syndrome: consensus guidance of the Asian Pacific Association for the study of the liver (APASL) |
2021 |
Hepatology International |
15 |
3 |
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531 |
567 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109622410&doi=10.1007%2fs12072-021-10189-4&partnerID=40&md5=727d2318980fa73306867439390cc762 |
Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Alka Hospital, Kathmandu, Nepal; Institute of Liver and Biliary Sciences, New Delhi, India; Christian Medical College, Vellore, India; Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan |
Shukla, A., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Shreshtha, A., Alka Hospital, Kathmandu, Nepal; Mukund, A., Institute of Liver and Biliary Sciences, New Delhi, India; Bihari, C., Institute of Liver and Biliary Sciences, New Delhi, India; Eapen, C.E., Christian Medical College, Vellore, India; Han, G., Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Deshmukh, H., Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Cua, I.H.Y., Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Lesmana, C.R.A., Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Al Meshtab, M., Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Kage, M., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Chaiteeraki, R., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Treeprasertsuk, S., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Giri, S., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Punamiya, S., Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Paradis, V., Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; Qi, X., General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Sugawara, Y., Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Abbas, Z., Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan; Sarin, S.K., Institute of Liver and Biliary Sciences, New Delhi, India |
Budd Chiari syndrome (BCS) is a diverse disease with regard to the site of obstruction, the predisposing thrombophilic disorders and clinical presentation across the Asia-Pacific region. The hepatic vein ostial stenosis and short segment thrombosis are common in some parts of Asia-Pacific region, while membranous obstruction of the vena cava is common in some and complete thrombosis of hepatic veins in others. Prevalence of myeloproliferative neoplasms and other thrombophilic disorders in BCS varies from region to region and with different sites of obstruction. This heterogeneity also raises several issues and dilemmas in evaluation and approach to management of a patient with BCS. The opportunity to recanalize hepatic vein in patients with hepatic vein ostial stenosis or inferior vena cava stenting or pasty among those membranous obstruction of the vena cava is a unique opportunity in the Asia–Pacific region to restore hepatic outflow closely mimicking physiology. In order to address these issues arising out of the diversity as well as the unique features in the region, the Asia Pacific Association for Study of Liver has formulated these guidelines for clinicians. © 2021, Asian Pacific Association for the Study of the Liver. |
Ascites; Budd Chiari syndrome; Hepatic vein stenting; Hepatocellular carcinoma; HVOTO; Liver biopsy; Liver transplant; MOVC; Portal hypertension; TIPS |
calreticulin; low molecular weight heparin; acute liver failure; acute on chronic liver failure; angioplasty; anticoagulant therapy; Article; Asia; blood clot lysis; blood clotting; Budd Chiari syndrome; cancer chemotherapy; chemoembolization; clinical feature; computer assisted tomography; Doppler flowmetry; female fertility; follow up; groups by age; hepatocellular adenoma; human; hyperhomocysteinemia; incidence; inferior cava vein; liver adenoma; liver cell carcinoma; liver nodule; liver transplantation; liver vein; nodular hyperplasia; nuclear magnetic resonance imaging; pathogenesis; postoperative complication; practice guideline; pregnancy; preoperative evaluation; prognosis; recanalization; risk factor; stent thrombosis; survival factor; thrombophilia; transjugular intrahepatic port |
Springer |
19360533 |
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34240318 |
Article |
Q2 |
1304 |
2874 |
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351 |
Wijaya A.N., Margiana R., Kusumaningtyas S., Furqonita D. |
57225105688;56685900600;57193925307;57191057597; |
Comparison of decomposition rate of hind limbs of preserved mice with ethanol-glycerin and formaldehyde of advanced fixative solution |
2021 |
Anatomy and Cell Biology |
54 |
2 |
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225 |
231 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109181614&doi=10.5115%2facb.20.314&partnerID=40&md5=b084cc2abbf0ad3096da22401b79fe9b |
Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wijaya, A.N., Undergraduate Program of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Margiana, R., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kusumaningtyas, S., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Furqonita, D., Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Learning anatomy in medical school is still closely based on the use of cadavers. The burial of preserved cadaver poses a problem, specifically, it contaminates the soil with formalin. Many studies have been conducted to find an alternative fixative to update or modify formalin usage. One of them is ethanol-glycerin (EG), which suggests promising results. Despite that fact, there has yet to be any research comparing the decomposition rate between EG and formalin. This study is conducted to compare the rate of decomposition between the two fixative solutions, EG and 4% formalin on the hind limb of mice. The mice were first preserved using a standard primary fixative solution which is 10% formalin, following that procedure is preservation using advanced fixative solution, EG or 4% formalin. Upon completing the preservation steps, the mice were buried for 6 weeks and observed weekly. The stages of decomposition were assessed semi-quantitatively depending on its appearance. The hind limbs of mice that were fixed with EG solution managed to reach the last stage of decomposition, dry & remains, while the 4% formalin group of mice still remained in the previous stage, advanced decay. It is concluded that the mice hind limbs that have been previously preserved with EG advanced fixative solution has a faster decomposition rate compared to 4% formalin. Copyright © 2021. Anatomy & Cell Biology |
Burial; Glycerol; Mice; Preservation |
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Korean Association of Anatomists |
20933665 |
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Article |
Q2 |
366 |
12934 |
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