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352 |
Kristin E., Endarti D., Khoe L.C., Taroeno-Hariadi K.W., Trijayanti C., Armansyah A., Sastroasmoro S. |
6504458442;56626162000;56586245200;37012289000;57203727260;57225098604;6507794136; |
Economic Evaluation of Adding Bevacizumab to Chemotherapy for Metastatic Colorectal Cancer (mCRC) Patients in Indonesia |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
6 |
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1921 |
1926 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109162811&doi=10.31557%2fAPJCP.2021.22.6.1921&partnerID=40&md5=8b230f77f7dbd1e3652b63db9226b4c0 |
Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Respira Hospital, Yogyakarta, Indonesia; Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kristin, E., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Endarti, D., Department of Pharmaceutics, Faculty of Pharmacy, Gadjah Mada University, Yogyakarta, Indonesia; Khoe, L.C., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Taroeno-Hariadi, K.W., Department of Pharmacology and Therapy, Faculty of Medicine Public Health and Nursing, Gadjah Mada University, Yogyakarta, Indonesia; Trijayanti, C., Respira Hospital, Yogyakarta, Indonesia; Armansyah, A., Center of Financing and Health Insurance, Ministry of Health, Government of Indonesia, Indonesia; Sastroasmoro, S., Department of Pediatrics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: Since 2016, bevacizumab has been widely used to treat metastatic colorectal cancer (mCRC) in Indonesia. Nevertheless, the high cost of bevacizumab has raised the question of whether the therapy is considered cost-effective and should be included in the national health insurance system. This study aimed to assess the cost-effectiveness of bevacizumab plus chemotherapy versus chemotherapy alone for the treatment of mCRC patients. Methods: A Markov model was applied using the perspective of the Indonesian healthcare system to assess cost-effectiveness. The health outcomes were expressed in terms of quality-adjusted life years (QALY) using the validated EuroQoL-5D-5L instrument. Data for medical costs were collected from hospital billings in four hospitals located in three different cities in Indonesia. Meanwhile, data for utility were obtained from interviewing 90 patients who came to the hospital. We compared those mCRC patients who received chemotherapy alone either with FOLFOX or FOLFIRI, versus patients who received the addition of bevacizumab. Results: With the perspective of societal, the incremental cost-effectiveness ratio (ICER) of adding bevacizumab was USD 49,312 per QALY gained using secondary data and USD 28,446 per QALY using real world data. Conclusion: Using either a healthcare or societal perspective, the addition of bevacizumab for mCRC treatment was considered not cost-effective. © 2021. All Rights Reserved. |
Metastatic colorectal cancer- bevacizumab- chemotherapy |
antineoplastic agent; bevacizumab; camptothecin; fluorouracil; folinic acid; platinum complex; colorectal tumor; cost benefit analysis; economics; human; Indonesia; Markov chain; metastasis; pathology; quality adjusted life year; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Camptothecin; Colorectal Neoplasms; Cost-Benefit Analysis; Fluorouracil; Humans; Indonesia; Leucovorin; Markov Chains; Neoplasm Metastasis; Organoplatinum Compounds; Quality-Adjusted Life Years |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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34181352 |
Article |
Q2 |
512 |
9866 |
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354 |
Wangsaputra V.K., Syarinta S., Louisa M. |
57215576000;57224977663;41461551400; |
Alpha-mangostin Reduces Cell Viability in Sorafenib-surviving Cells by Modulating Multiple Drug Transporters in Hepg2 Hepatocellular Carcinoma Cells |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
6 |
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105 |
110 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108813859&doi=10.7324%2fJAPS.2021.110612&partnerID=40&md5=eec4655af84852758d672bc24d8bc83b |
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Wangsaputra, V.K., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Syarinta, S., Department of Pharmacology, Faculty of Medicine, YARSI University, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
A previous study showed that alpha-mangostin (AM) showed benefit when given to sorafenib (SOR)-surviving cells. However, the mechanism was not fully understood. The present study aimed to understand the effect of AM on SOR-surviving cells and its agent concerning drug transporters. SOR-surviving cells were treated with SOR 10 μM. Surviving cells were divided into four groups of treatment, namely, vehicle only dimethyl sulfoxide (DMSO), SOR 10 μM, AM 20 μM, or combination of SOR 10 μM-AM 20 μM. As controls, HepG2 naïve cells were treated with DMSO only or AM 20 μM. Cell viability was counted using trypan blue exclusion assay. Simultaneously, the mRNA expressions of P-glycoprotein (P-gp), ABCG2, MRP2, MRP3, OCT1, and OATP1B3 drug transporters were examined with quantitative reverse transcriptase-polymerase chain reaction. Decreased mRNA expression of P-gp was found in SOR-surviving cells treated with SOR. In contrast, AM alone or SOR's combination caused a significant increase in both efflux and influx transporters, no difference in fold increase of all transporters evaluated in AM versus SOR-AM combinations. Generally, AM treatment increased the mRNA expression of all the drug transporters. © 2021 Vincent Kharisma Wangsaputra et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Alpha-mangostin; drug transporters; OCT1; P-glycoprotein; sorafenib resistance |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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356 |
Fadilah F., Erlina L., Paramita R.I., Istiadi K.A. |
56966708600;57190181680;54882436900;57224568113; |
Immunoinformatics Studies and Design of Breast Cancer Multiepitope Peptide Vaccines: Diversity Analysis Approach |
2021 |
Journal of Applied Pharmaceutical Science |
11 |
6 |
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035 |
045 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108795156&doi=10.7324%2fJAPS.2021.110604&partnerID=40&md5=36bb41265fd86ae6763c0ce748625cb9 |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Fadilah, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Erlina, L., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Paramita, R.I., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Istiadi, K.A., Bioinformatics Core Facilities, Indonesian Medical Education and Research Institute IMERI, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Breast cancer is one of the most diagnosed cancers in women; the number of cases continues to rise. The high prevalence and increased incidence need more attention in developing effective therapy. Current passive therapy has several drawbacks that have not yet been resolved. Thus, an alternative and preventive therapy for cancer is needed by utilizing vaccines. Immunoinformatics approach is one of the promising methods predicting epitopes in vaccine research. This approach could accelerate the initial study process of vaccine development and reduce research costs. Epitope conservancy and vaccine coverage are important parameters in vaccine research due to addressing the variability and diversity of cancer genomics. This study will be carried out on the multiepitope characterization of potential T cells against the protein mechanism in breast cancer. Proteins used in this study are Mucin-4, Phosphatase And Tensin Homolog, and Receptor tyrosine-protein kinase erbB-2. CTL epitopes, antigenicity, immunogenicity, allergenicity, and toxicity were predicted for the peptide vaccine. Immunoinformatics analysis generates a multiepitope sequence consisting of seven epitopes: DPVALVAPF, SVAYRLGTL, SQINTLNTL, RFRELVSEF, VTSANIQEF, RPRFRELVS, and MYFEFPQPL by AAY linker. The docking and molecular dynamics analyses were conducted to confirm the interactions between the multiepitope vaccine molecule and TLR-4-MD. The multiepitope vaccine construct can be an appropriate choice for further experiments. © 2021 Fadilah Fadilah et al. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/). |
Breast cancer; immunoinformatics; multiepitope; peptide vaccine design; vaccine |
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Open Science Publishers LLP Inc. |
22313354 |
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Article |
Q2 |
286 |
15310 |
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358 |
Notonegoro C., Nareswari I. |
57224857889;57194336586; |
A Single Session of Acupuncture Therapy with Combination of Balance Method and Distal Point for the Treatment of Shoulder Calcific Tendinitis: A Case Report |
2021 |
Medical Acupuncture |
33 |
3 |
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240 |
245 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108429586&doi=10.1089%2facu.2020.1454&partnerID=40&md5=9462d25f59bc3264416a9e97290ac99e |
Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia; Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia |
Notonegoro, C., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia, Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia; Nareswari, I., Medical Acupuncture Specialist Program, Faculty of Medicine, Universitas Indonesia, Jakarta, 10440, Indonesia, Department of Medical Acupuncture, RSUPN Dr. Cipto Mangunkusumo, Jakarta, Indonesia |
Background: Tendinitis is a term that is often used to describe various regional musculoskeletal conditions that are common and often occur, which are described mainly by pain and disability at the affected site. In calcareous (or calcific) tendinitis (CT) of the shoulder, a calcified deposit (hydroxyapatite) is located within 1 or more of the rotator cuff tendons (commonly the supraspinatus). CT is found in 10%-42% of chronic shoulder pain. Conservative treatment is always the first line of treatment. Acupuncture has been widely accepted by patients who experience musculoskeletal pain compared with other nonsurgical modalities and it is a minimal risk intervention. Case: A 56-year-old woman was diagnosed with shoulder CT. Physical examination revealed limited range of motion (ROM) in abduction (78.6°) and lateral rotation (82.5°) of the right shoulder joint with a pain scale using numeric rating scale (NRS) assessment score of 5 (with diclofenac sodium 2 × 50 mg since 1 day ago). She received single session of acupuncture with balance method and distal point with a total of 10 needles, then all needles were retained for 45 minutes and the therapy was done only unilaterally. Then follow-up was made 2 days later. Results: After the session ended, NRS assessment score reduced from 5 to 2, ROM in abduction and lateral rotation of the right shoulder was improved, respectively, to 179.2° and 150.4°. In follow-up 2 days after, ROM in abduction and lateral rotation became 168.9° and 147.8°, respectively, and NRS was still 2. Conclusions: Acupuncture with the use of the balance method and distal point effectively relieved the pain and improved ROM of CT even after 2 days. © Copyright 2021, Mary Ann Liebert, Inc., publishers 2021. |
acupuncture; balance method; calcific tendinitis; shoulder pain |
analgesic agent; diclofenac; abduction; acupuncture; adult; Article; blood pressure; case report; clinical article; female; follow up; human; jianjing acupoint; middle aged; numeric rating scale; pain assessment; physical examination; range of motion; rotation; shoulder disease; shoulder pain; tendinitis |
Mary Ann Liebert Inc. |
19336586 |
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Article |
Q2 |
281 |
15498 |
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360 |
Yunir E., Tahapary D.L., Tarigan T.J.E., Harbuwono D.S., Oktavianda Y.D., Kristanti M., Iswati E., Sarumpaet A., Soewondo P. |
36520254800;55944492500;36057746500;36056341600;57224499358;57208222835;57224505254;57193017794;23475336100; |
Non-vascular contributing factors of diabetic foot ulcer severity in national referral hospital of Indonesia |
2021 |
Journal of Diabetes and Metabolic Disorders |
20 |
1 |
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805 |
813 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107722068&doi=10.1007%2fs40200-021-00827-x&partnerID=40&md5=b307a628bc17237466c173d4d63b13aa |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harbuwono, D.S., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavianda, Y.D., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kristanti, M., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iswati, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sarumpaet, A., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: Diabetic foot ulcer (DFU) is a common chronic complication of type 2 diabetes mellitus (T2DM) in Indonesia, with a prevalence of 7.3%. However, the characteristics of these patients remain unclear. We investigated the characteristics of patients with DFU without peripheral arterial disease (PAD) and analyzed non-vascular factors related to severity of DFU in a tertiary care national referral hospital in Indonesia. Methods: This was a cross-sectional study including 123 hemodynamically stable DFU patients without PAD recruited from Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia from 2010–2015. Results: DFU patients were predominantly over 50 years old (75.6%) and diagnosed with T2DM for 5 years with poor glycemic control (82.7%) and peripheral neuropathy (91.3%). Most patients had anemia (86.7%), leukocytosis (84.6%), and were undernourished, as characterized by a low lipid profile (90.8%) and hypoalbuminemia (83.7%). Most had extensive size of ulcer at the initial visit, with a median size of 16.23 (2.92–60.16) cm2. Ulcers were mostly located of the forefoot (62.5%) and were caused by mechanical trauma (46.2%). Bivariate analysis revealed that significant factors for the development of DFU were related to DFU size, including duration of T2DM (p = 0.04), leukocyte levels (p = < 0.01), and thrombocyte levels (p = < 0.01). Multivariate analysis showed leucocyte (p = 0.03) and thrombocyte (p = 0.023) had significantly correlated with DFU severity. Conclusion: Leucocyte and thrombocyte may be the greatest contributing non-vascular factors for severity of DFU in Indonesia. © 2021, Springer Nature Switzerland AG. |
Diabetic foot ulcer; Leucocyte; Non-vascular factor; Thrombocyte |
adult; anemia; Article; clinical feature; controlled study; correlational study; cross-sectional study; diabetic foot; disease association; disease course; disease duration; disease severity; female; forefoot; glycemic control; hemodynamics; human; hypoalbuminemia; Indonesia; leukocyte count; leukocytosis; lipid analysis; major clinical study; male; malnutrition; non insulin dependent diabetes mellitus; peripheral neuropathy; platelet count; tertiary care center |
Springer Science and Business Media Deutschland GmbH |
22516581 |
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Article |
Q2 |
619 |
8164 |
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365 |
Duc N.T.M., Loc L.Q., Alhady S.T.M., Sabir D.M.E., Mai L.N., Dumre S.P., Hassan A.K., Giang T.V., Thach P.N., Truong L.V., Ravikulan R., Raut A., Dayyab F.M., Trang V.T.T., Huy N.T., Imoto A., Dumre R.B., Ranabhat K., Sharma G.N., Habaj N.A., Elnoamany S., Aziz J.M.A., Crispino K.T., Alsuwiyah S., Hussein R.M., Hama D.J., Morena G.J.V., Aritonang R.S., Rocha I.C.N., Pavlenko D., Kareem H.F.H., Antora R.J., Lopez A.S.E., Gubari M.I.M., Koonrungsesomboon N., Takuathung M.N., Ruengorn C., Nochaiwong S., Kanjanarat P., Elhassan S.M., Dzhemiliev A., Olvera B.P.G., Haque M.A., Ullah I., Dajti I., Kërpaçi J., Vrapi E., Venkatesh U., Hassan Z., Ahmed Z.S., Alrahman M.F., Khanh T.T., Qarawi A.T.A., Kudlatska-Tyshko I., Ali I., Ng S.J., Nghia P.T., Pavlenko M., Abbas K.S., Omran H.A.M., Rezq C.S., Ibrahim M.I.A., Ragheb M.S., Monib F.A., Said A.E., Ahmed S.F., Hamed Z.H., Nageh M.A., Sayed E., Shibani M., Ismail A.H., Alzabibi M.A., Sawaf B., Chuah J., Lim Y.L., Jee Y.S., Hamed A.H.M., Miranda A.V., Kubota K., Aoki K., Gyanwali P., Dhimal M., Koirala P., Adhikari K., Lucas F., Ordóñez J.N.P., Aburto J.T.O., Chong L.C., Younes B., Pavlenko R., Iqtadar S., Ghani U., Mumtaz S.U., Khan A.A., TMGH-Global COVID-19 Collaborative |
57199622107;57218120041;57224078312;57224082661;57224089160;35321918400;57220065688;57224091973;57224072368;57224082619;57224095725;57218407158;56580399700;57224073089;57209480434;56216340000;57224070842;56622984700;57225749183;57224068325;57223975589;57224097004;57224087649;57222960525;57224071699;57224073174;57224086154;57224080363;57223283646;57204158719;57224068925;57224089935;57224081202;57210795029;56288783600;57224077120;53878308600;57189848094;22992871700;57224069299;57220175050;57224091480;57218448682;57211152020;57218993911;57224092581;57221615805;57218892210;57215818914;57225670959;57224080553;57224086420;57224096129;57224087241;57223368799;57223195386;57224069007;57224069023;57223185385;57224095939;57224089287;57224086484;57224099028;57219123965;57222138764;57224098010;57224076675;57224090223;57224097163;57219773848;57224091545;57219774505;57195679503;57224073773;57224092806;57224072085;57224070356;57222664687;57201680054;57224094037;57194476849;54941157300;57224089702;56339701500;57224080691;57224090794;57224082163;57224092414;57224079470;56594973400;37661545300;57224097377;57224079051;57224093195; |
Psychological impacts and post-traumatic stress disorder among people under COVID-19 quarantine and isolation: A global survey |
2021 |
International Journal of Environmental Research and Public Health |
18 |
11 |
5719 |
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4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106936924&doi=10.3390%2fijerph18115719&partnerID=40&md5=843d98405f6225b81732a50db6f59ae0 |
Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Faculty of Medicine, University of Gezira, Wad Medani, Sudan; Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal; Faculty of Medicine, South Valley University, Qena, Egypt; Department of Infectious Disease, Hanoi Medical University, Hanoi, Viet Nam; Traditional Medicine Hospital, Ministry of the Public Security, Hanoi, Viet Nam; Southern Adelaide Local Health Network, Adelaide, Australia; Rajarshee Chhatrapati Shahu Maharaj Govt Medical College, Kolhapur, India; Infectious Disease Hospital, Kano, Nigeria; National Hospital of Traditional Medicine, Hanoi, Viet Nam; School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Ministry of Health and Population, Kathmandu, Nepal; Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; Faculty of medicine, University of Tours, Tours, France; Faculty of Medicine, Menoufia University, Menoufia, Egypt; Medical Laboratory Science, College of Health Sciences, University of Human Development, Sulaymaniyah, Kurdistan region, Iraq; Baxshin Research Center, Baxshin Hospital, Sulaymaniyah, Kurdistan Region, Iraq; Health Emergency Management Bureau, Department of Health, Manila, Philippines; Faculty of Medicine, University of Tripoli, Tripoli, Libyan Arab Jamahiriya; Baxshin Research Center, Baxshin Hospital, Sulaymaniyah, Kurdistan region, Iraq; Faculty of Medicine, Trisakti University, Jakarta, Indonesia; America Evangelical University, Los Angeles, CA, United States; Yadika General Hospital, Jakarta, Indonesia; School of Medicine, Centro Escolar University, Manila, Philippines; Department of Ophthalmology, Bogomolets National Medical University, Kyiv, Ukraine; Department of Psychiatry, Mental Health Center, Awesar Medical Building Sulaymaniyah, Kurdistan region, Iraq; Qilu Hospital, Shandong University, Jinan, Shandong, China; Faculty of Medicine, Pontificia Universidad Católica del Ecuador, Quito, Ecuador; Department of Family and Community Medicine, College of Medicine, University of Sulaimaniyah, Sulaimaniyah, Kurdistan Region, Iraq; Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand; Faculty of Medicine, Alneelain University, Khartoum, Sudan; Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine; Autonomous University of Mexico State, Toluca, Mexico; Department of Orthopedic Surgery, Yan an hospital affiliated to Kunming Medical University, Kunming, Yunnan, China; Kabir Medical College, Gandhara University, Peshawar, Pakistan; UHOG ‘Koço Gliozheni’, Tirana, Albania; Department of Community Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India; Cardiology department, Lady Reading Hospital, Peshawar, Pakistan; Faculty of Medicine, Cairo University, Egypt; University of Bakhat alruda, Ed Dueim, Sudan; Faculty of Medicine, School of Medicine and Pharmacy, Da Nang University, Da Nang City, Viet Nam; Lower Westchester Medical Associates, P.C., Mount Vernon, NY, United States; Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine; Paraplegic Center, Hayatabad Peshawar, Pakistan; Department of Medicine, Crozer-Chester Medical Center, Upland, PA, United States; Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam; Kyiv City Pediatric Diagnostic Center, Kyiv, Ukraine; Faculty of Medicine, Alexandria University, Alexandria, Egypt; Faculty of Medicine, Assiut University, Assiut, Egypt; Faculty of Medicine, Syrian Private University, Damascus, Syrian Arab Republic; School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; Faculty of Medicine, Cairo University, Cairo, Egypt; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Biostatistics, Yokohama City University, Yokohama, Japan; Graduate School of Nursing, Chiba University, Chiba, Japan; Nepal Health Research Council, Kathmandu, Nepal; Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Faculty of Medicine, Catholic University of Honduras, Honduras; Faculty of Medicine, Universidad de La Frontera, Temuco, Chile; School of Data Sciences, Perdana University, Kuala Lumpur, Malaysia; Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco; Bogomolets National Medical University, Kyiv, Ukraine; King Edward Medical University, Lahore, Pakistan; Directorate General Health Services, Lahore, Pakistan; North Medical Ward, KEMU/Mayo Hospital, Lahore, Pakistan; Khyber Teaching Hospital, Peshawar, Pakistan |
Duc, N.T.M., Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Loc, L.Q., Faculty of Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Alhady, S.T.M., Faculty of Medicine, University of Gezira, Wad Medani, Sudan; Sabir, D.M.E., Faculty of Medicine, University of Gezira, Wad Medani, Sudan; Mai, L.N., Department of Internal Medicine, University of Medicine and Pharmacy at Ho Chi Minh City, Ho Chi Minh City, Viet Nam; Dumre, S.P., Central Department of Microbiology, Tribhuvan University, Kathmandu, Nepal; Hassan, A.K., Faculty of Medicine, South Valley University, Qena, Egypt; Giang, T.V., Department of Infectious Disease, Hanoi Medical University, Hanoi, Viet Nam; Thach, P.N., Department of Infectious Disease, Hanoi Medical University, Hanoi, Viet Nam; Truong, L.V., Traditional Medicine Hospital, Ministry of the Public Security, Hanoi, Viet Nam; Ravikulan, R., Southern Adelaide Local Health Network, Adelaide, Australia; Raut, A., Rajarshee Chhatrapati Shahu Maharaj Govt Medical College, Kolhapur, India; Dayyab, F.M., Infectious Disease Hospital, Kano, Nigeria; Trang, V.T.T., National Hospital of Traditional Medicine, Hanoi, Viet Nam; Huy, N.T., School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Imoto, A., School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Dumre, R.B., School of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan; Ranabhat, K., Ministry of Health and Population, Kathmandu, Nepal, Institute of Medicine, Tribhuvan University, Kathmandu, Nepal; Sharma, G.N., Ministry of Health and Population, Kathmandu, Nepal; Habaj, N.A., Faculty of medicine, University of Tours, Tours, France; Elnoamany, S., Faculty of Medicine, Menoufia University, Menoufia, Egypt; Aziz, J.M.A., Medical Laboratory Science, College of Health Sciences, University of Human Development, Sulaymaniyah, Kurdistan region, Iraq, Baxshin Research Center, Baxshin Hospital, Sulaymaniyah, Kurdistan Region, Iraq; Crispino, K.T., Health Emergency Management Bureau, Department of Health, Manila, Philippines; Alsuwiyah, S., Faculty of Medicine, University of Tripoli, Tripoli, Libyan Arab Jamahiriya; Hussein, R.M., Baxshin Research Center, Baxshin Hospital, Sulaymaniyah, Kurdistan region, Iraq; Hama, D.J., Baxshin Research Center, Baxshin Hospital, Sulaymaniyah, Kurdistan region, Iraq; Morena, G.J.V., Faculty of Medicine, Trisakti University, Jakarta, Indonesia, America Evangelical University, Los Angeles, CA, United States; Aritonang, R.S., Faculty of Medicine, Trisakti University, Jakarta, Indonesia, Yadika General Hospital, Jakarta, Indonesia; Rocha, I.C.N., School of Medicine, Centro Escolar University, Manila, Philippines; Pavlenko, D., Department of Ophthalmology, Bogomolets National Medical University, Kyiv, Ukraine; Kareem, H.F.H., Department of Psychiatry, Mental Health Center, Awesar Medical Building Sulaymaniyah, Kurdistan region, Iraq; Antora, R.J., Qilu Hospital, Shandong University, Jinan, Shandong, China; Lopez, A.S.E., Faculty of Medicine, Pontificia Universidad Católica del Ecuador, Quito, Ecuador; Gubari, M.I.M., Department of Family and Community Medicine, College of Medicine, University of Sulaimaniyah, Sulaimaniyah, Kurdistan Region, Iraq; Koonrungsesomboon, N., Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Takuathung, M.N., Department of Pharmacology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Ruengorn, C., Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand; Nochaiwong, S., Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand; Kanjanarat, P., Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Chiang Mai, Thailand; Elhassan, S.M., Faculty of Medicine, Alneelain University, Khartoum, Sudan; Dzhemiliev, A., Shalimov National Institute of Surgery and Transplantology, Kyiv, Ukraine; Olvera, B.P.G., Autonomous University of Mexico State, Toluca, Mexico; Haque, M.A., Department of Orthopedic Surgery, Yan an hospital affiliated to Kunming Medical University, Kunming, Yunnan, China; Ullah, I., Kabir Medical College, Gandhara University, Peshawar, Pakistan; Dajti, I., UHOG ‘Koço Gliozheni’, Tirana, Albania; Kërpaçi, J., UHOG ‘Koço Gliozheni’, Tirana, Albania; Vrapi, E., UHOG ‘Koço Gliozheni’, Tirana, Albania; Venkatesh, U., Department of Community Medicine, Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India; Hassan, Z., Cardiology department, Lady Reading Hospital, Peshawar, Pakistan; Ahmed, Z.S., Faculty of Medicine, Cairo University, Egypt; Alrahman, M.F., University of Bakhat alruda, Ed Dueim, Sudan; Khanh, T.T., Faculty of Medicine, School of Medicine and Pharmacy, Da Nang University, Da Nang City, Viet Nam; Qarawi, A.T.A., Lower Westchester Medical Associates, P.C., Mount Vernon, NY, United States; Kudlatska-Tyshko, I., Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine; Ali, I., Paraplegic Center, Hayatabad Peshawar, Pakistan; Ng, S.J., Department of Medicine, Crozer-Chester Medical Center, Upland, PA, United States; Nghia, P.T., Faculty of Medicine, Pham Ngoc Thach University of Medicine, Ho Chi Minh City, Viet Nam; Pavlenko, M., Kyiv City Pediatric Diagnostic Center, Kyiv, Ukraine; Abbas, K.S., Faculty of Medicine, Alexandria University, Alexandria, Egypt; Omran, H.A.M., Faculty of Medicine, Alexandria University, Alexandria, Egypt; Rezq, C.S., Faculty of Medicine, Alexandria University, Alexandria, Egypt; Ibrahim, M.I.A., Faculty of Medicine, Alexandria University, Alexandria, Egypt; Ragheb, M.S., Faculty of Medicine, Alexandria University, Alexandria, Egypt; Monib, F.A., Faculty of Medicine, Assiut University, Assiut, Egypt; Said, A.E., Faculty of Medicine, Assiut University, Assiut, Egypt; Ahmed, S.F., Faculty of Medicine, Assiut University, Assiut, Egypt; Hamed, Z.H., Faculty of Medicine, Assiut University, Assiut, Egypt; Nageh, M.A., Faculty of Medicine, Assiut University, Assiut, Egypt; Sayed, E., Faculty of Medicine, Assiut University, Assiut, Egypt; Shibani, M., Faculty of Medicine, Syrian Private University, Damascus, Syrian Arab Republic; Ismail, A.H., Faculty of Medicine, Syrian Private University, Damascus, Syrian Arab Republic; Alzabibi, M.A., Faculty of Medicine, Syrian Private University, Damascus, Syrian Arab Republic; Sawaf, B., Faculty of Medicine, Syrian Private University, Damascus, Syrian Arab Republic; Chuah, J., School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; Lim, Y.L., School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; Jee, Y.S., School of Medical Sciences, Universiti Sains Malaysia, Kelantan, Malaysia; Hamed, A.H.M., Faculty of Medicine, Cairo University, Cairo, Egypt; Miranda, A.V., Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kubota, K., Department of Biostatistics, Yokohama City University, Yokohama, Japan; Aoki, K., Graduate School of Nursing, Chiba University, Chiba, Japan; Gyanwali, P., Nepal Health Research Council, Kathmandu, Nepal; Dhimal, M., Nepal Health Research Council, Kathmandu, Nepal; Koirala, P., Nepal Health Research Council, Kathmandu, Nepal; Adhikari, K., Nepal Health Research Council, Kathmandu, Nepal; Lucas, F., Faculty of Medicine, University of Lisbon, Lisbon, Portugal; Ordóñez, J.N.P., Faculty of Medicine, Catholic University of Honduras, Honduras; Aburto, J.T.O., Faculty of Medicine, Universidad de La Frontera, Temuco, Chile; Chong, L.C., School of Data Sciences, Perdana University, Kuala Lumpur, Malaysia; Younes, B., Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakesh, Morocco; Pavlenko, R., Bogomolets National Medical University, Kyiv, Ukraine; Iqtadar, S., King Edward Medical University, Lahore, Pakistan; Ghani, U., Directorate General Health Services, Lahore, Pakistan; Mumtaz, S.U., North Medical Ward, KEMU/Mayo Hospital, Lahore, Pakistan; Khan, A.A., Khyber Teaching Hospital, Peshawar, Pakistan; TMGH-Global COVID-19 Collaborative |
Understanding the presence of post-traumatic stress disorder (PTSD) symptoms in quarantined/ isolated individuals is essential for decreasing morbidity and mortality caused by the COVID-19 pandemic. However, there is a paucity of evidence quantifying PTSD status globally during confinement in quarantine/isolation facilities during COVID-19. Therefore, we aimed to assess the PTSD status and factors contributing to PTSD development in quarantined/isolated people during pandemic. Using the Impact of Event Scale-Revised (IES-R) scale, our multicentre, multinational, and cross-sectional online survey assessed the psychological impacts on the quarantine/isolation experience of participants suspected or confirmed to have COVID-19, their PTSD status, and various correlates with developing PTSD. We had 944 (35.33%) valid responses (51.1% from females), mostly from Asian countries (635, 71.4%), and 33.9% were healthcare workers. The number of quarantine days in the PTSD symptoms group (using the IES-R cutoff of 24 for symptomatic or full PTSD) was significantly shorter compared to the non-PTSD group (14 (range 14-40) vs. 14 (14-23.75), p = 0.031). Lower rates of PTSD symptoms were observed in participants practicing Buddhist religion than in participants having no religion (OR: 0.30; 95% CI: 0.13-0.68; p = 0.005); individuals with vocational training had a higher risk of developing PTSD symptoms (OR: 2.28 (1.04-5.15); p = 0.043) compared to university graduates. Individuals forced to be quarantined/isolated had higher odds of developing PTSD symptoms than those voluntarily quarantined/isolated (OR: 2.92 (1.84-4.74); p < 0.001). We identified several PTSD correlations among individuals quarantined/isolated during the COVID-19 pandemic, including religious practice, reason for quarantine/isolation, education level, and being a case of the infection. These findings can inform worldwide policies to minimize the adverse effects of such social control measures. © 2021 by the author. |
COVID-19; Global survey; Impact of event-scale; Isolation; Mental health; Pandemic; PTSD; Quarantine |
COVID-19; developing world; epidemiology; health worker; mental disorder; psychology; religion; survey method; adult; Article; Asian; controlled study; coronavirus disease 2019; cross-sectional study; female; health care personnel; health survey; human; Impact of Events Scale; major clinical study; male; mental health; multicenter study; pandemic; patient isolation; posttraumatic stress disorder; psychological aspect; quarantine; questionnaire; religion; symptom; vocational education |
MDPI |
16617827 |
|
34073524 |
Article |
Q2 |
747 |
6560 |
|
|
369 |
Yugo D., Lo L.-W., Wu Y.-H., Chung F.-P., Lin Y.-J., Chang S.-L., Hu Y.-F., Chao T.-F., Liao J.-N., Chang T.-Y., Lin C.-Y., Tuan T.-C., Kuo L., Wu C.-I., Liu C.-M., Liu S.-H., Cheng W.-H., Lugtu I.C., Jain A., Chen S.-A. |
57215499689;25224685100;57150405500;40560956700;56512618600;57154909400;57219519883;35335897300;55179923000;56763173800;56469967500;7005704090;57193883698;56320807100;57202736753;57191375309;26025932500;57212467736;57216788165;57211727582; |
Case series on stereotactic body radiation therapy in non-ischemic cardiomyopathy patients with recurrent ventricular tachycardia |
2021 |
PACE - Pacing and Clinical Electrophysiology |
44 |
6 |
|
1085 |
1093 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105961876&doi=10.1111%2fpace.14254&partnerID=40&md5=d3ccf6f5cafcbd0b6064e6a5a180d5ce |
Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia; Arrhythmia Division, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan; Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Heart Institute, Chinese General Hospital and Medical Center, Metro Manila, Philippines; Department of Cardiology, Vardhman Mahavir Medical College, New Delhi, India; Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
Yugo, D., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Cardiology and Vascular Medicine, Faculty of Medicine University of Indonesia, Jakarta, Indonesia, Arrhythmia Division, Pusat Jantung Nasional Harapan Kita, Jakarta, Indonesia; Lo, L.-W., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Wu, Y.-H., Division of Radiation Oncology, Department of Oncology, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Department of Biomedical Imaging and Radiological Sciences, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chung, F.-P., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lin, Y.-J., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chang, S.-L., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Hu, Y.-F., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chao, T.-F., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liao, J.-N., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Chang, T.-Y., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lin, C.-Y., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Tuan, T.-C., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Kuo, L., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Wu, C.-I., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liu, C.-M., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Liu, S.-H., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Cheng, W.-H., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan; Lugtu, I.C., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Heart Institute, Chinese General Hospital and Medical Center, Metro Manila, Philippines; Jain, A., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Department of Cardiology, Vardhman Mahavir Medical College, New Delhi, India; Chen, S.-A., Heart Rhythm Center, Division of Cardiology, Department of Internal Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Faculty of Medicine and Institute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, Cardiovascular Center, Taichung Veterans General Hospital, Taichung, Taiwan |
Introduction: The efficacy of stereotactic body radiation therapy (SBRT) as an alternative treatment for recurrent ventricular tachycardia (VT) is still unclear. This study aimed to report the outcome of SBRT in VT patients with nonischemic cardiomyopathy (NICM). Methods: The determination of the target substrate for radiation was based on the combination of CMR results and electroanatomical mapping merged with the real-time CT scan image. Radiation therapy was performed by Flattening-filter-free (Truebeam) system, and afterward, patients were followed up for 13.5 ± 2.8 months. We analyzed the outcome of death, incidence of recurrent VT, ICD shocks, anti-tachycardia pacing (ATP) sequences, and possible irradiation side-effects. Results: A total of three cases of NICM patients with anteroseptal scar detected by CMR. SBRT was successfully performed in all patients. During the follow-up, we found that VT recurrences occurred in all patients. In one patient, it happened during a 6-week blanking period, while the others happened afterward. Re-hospitalization due to VT only appeared in one patient. Through ICD interrogation, we found that all patients have reduced VT burden and ATP therapies. All of the patients died during the follow-up period. Radiotherapy-related adverse events did not occur in all patients. Conclusions: SBRT therapy reduces the number of VT burden and ATP sequence therapy in NICM patients with VT, which had a failed previous catheter ablation. However, the efficacy and safety aspects, especially in NICM cases, remained unclear. © 2021 Wiley Periodicals LLC |
radio-ablation; stereotactic; ventricular tachycardia |
aged; Article; cardiovascular magnetic resonance; case report; clinical article; clinical effectiveness; clinical outcome; computer assisted tomography; death; disease burden; female; follow up; heart pacing; heart ventricle tachycardia; hospital readmission; human; incidence; male; nonischemic cardiomyopathy; recurrent disease; stereotactic body radiation therapy; very elderly; cardiomyopathy; diagnostic imaging; epicardium mapping; heart ventricle tachycardia; procedures; radiosurgery; radiotherapy dosage; scar; x-ray computed tomography; Aged; Aged, 80 and over; Cardiomyopathies; Cicatrix; Epicardial Mapping; Female; Humans; Male; Radiosurgery; Radiotherapy Dosage; Tachycardia, Ventricular; Tomography, X-Ray Computed |
John Wiley and Sons Inc |
01478389 |
|
33932305 |
Article |
Q2 |
686 |
7284 |
|
|
376 |
Dewiasty E., Setiati S., Agustina R., Roosheroe A.G., Abdullah M., Istanti R., de Groot L.C. |
55257705500;14325991900;57214141404;28767975000;7103393434;23496653300;57213769769; |
Prevalence of lactose intolerance and nutrients intake in an older population regarded as lactase non-persistent |
2021 |
Clinical Nutrition ESPEN |
43 |
|
|
317 |
321 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104952533&doi=10.1016%2fj.clnesp.2021.03.033&partnerID=40&md5=afacacb3695eb5029eae5ee3bb8270ab |
Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 176700, Wageningen, AA, Netherlands; Center of Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta Indonesia, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Jl., Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia |
Dewiasty, E., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia, Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 176700, Wageningen, AA, Netherlands; Setiati, S., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia, Center of Clinical Epidemiology and Evidence-Based Medicine, Faculty of Medicine Universitas Indonesia – Dr. Cipto Mangunkusumo Hospital, Jakarta Indonesia, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Jl., Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine Universitas Indonesia, Jl. Salemba Raya No. 6, Jakarta Pusat, DKI Jakarta 10430, Indonesia; Roosheroe, A.G., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Abdullah, M., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; Istanti, R., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Pangeran Diponegoro No 71, Kenari, Senen, Jakarta PusatDKI Jakarta 10430, Indonesia; de Groot, L.C., Division of Human Nutrition and Health, Wageningen University and Research, P.O. Box 176700, Wageningen, AA, Netherlands |
Background and aims: Energy and nutrient intakes of community-dwelling older adults in Indonesia are inadequate whereby milk consumption is among the lowest in the world. Lactose intolerance is probably one of the reasons for such low milk consumption, but information on the burden of this problem and its consequences for dietary intake is lacking. We obtained data on the prevalence of lactose intolerance and dietary intakes in Indonesian older outpatients, thereby comparing dairy users and non-dairy users. Methods: A cross-sectional study was conducted in 2019 involving 103 community-dwelling older adults in the outpatient geriatric clinic, Dr. Cipto Mangunkusumo Hospital, Jakarta. A structured questionnaire was used to categorize participants as dairy- or non-dairy users. Food records were collected to assess nutrients intake from the diet. The prevalence of lactose intolerance (LI) was estimated based on the results of the hydrogen breath test (HBT) and on symptoms of lactose malabsorption. The difference in LI prevalence between dairy- and non-dairy user group was presented as a prevalence ratio (with 95% confidence interval). Chi-square tests, t-test, and Mann–Whitney tests were used to evaluate differences in demographic and clinical characteristics, as well as in nutrient intake profiles between dairy and non-dairy users. Results: The prevalence of lactose intolerance amounted to 66% (57–75%), 54% (37–70%), and 73% (61–84%) in the total population, dairy- and non-dairy users, respectively. Lactose intolerance tended to be higher among non-dairy users (PR 1.36 95% CI 0.99–1.89). On the other hand, we found no pronounced differences in symptoms of lactose intolerance between dairy and non-dairy users. The overall mean protein, calcium, vitamin D, and vitamin B12 intakes of the older adults were low. Intakes of protein, calcium, vitamin D and vitamin B12 were higher among dairy than among non-dairy users. Conclusions: This study uncovered the large size of the lactose intolerance problem in Indonesian older adults. Especially in non-dairy users, the intakes of proteins and some micronutrients are a concern. Strategies to tackle lactose intolerance are most relevant as to open the door for more nutrient-dense foods in the diet of Indonesian older adults. © 2021 European Society for Clinical Nutrition and Metabolism |
Indonesia; Lactase non-persistent; Lactose intolerance; Nutrients intake; Older adults |
calcium; cyanocobalamin; lactase; vitamin D; adult; aged; Article; cross-sectional study; dietary intake; female; human; hydrogen breath test; lactose intolerance; male; middle aged; Mini-Nutritional Assessment; nutrient intake; nutritional assessment; nutritional status; prevalence; structured questionnaire; vitamin intake |
Elsevier Ltd |
24054577 |
|
34024534 |
Article |
Q2 |
659 |
7601 |
|
|
379 |
Pranata R., Lim M.A., Huang I., Yonas E., Henrina J., Vania R., Lukito A.A., Nasution S.A., Alwi I., Siswanto B.B. |
57201973901;57216039756;57208576645;57201987097;57218482646;57208328436;57213835420;57189373134;15055173800;14422648800; |
Visceral adiposity, subcutaneous adiposity, and severe coronavirus disease-2019 (COVID-19): Systematic review and meta-analysis |
2021 |
Clinical Nutrition ESPEN |
43 |
|
|
163 |
168 |
|
9 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104309308&doi=10.1016%2fj.clnesp.2021.04.001&partnerID=40&md5=e8122f7c8b69f82d927a6b4a78d83d7a |
Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia; Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Huang, I., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Hasan Sadikin General Hospital, Bandung, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Udayana University, Sanglah General Hospital, Bali, Indonesia; Lukito, A.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Department of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia; Nasution, S.A., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Alwi, I., Division of Cardiology, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia/ Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siswanto, B.B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia |
Background and aims: Body mass index (BMI) has previously been shown to increase mortality and disease severity in patients with COVID-19, but the pooled effect estimate was heterogeneous. Although BMI is widely used as an indicator, it cannot distinguish visceral from subcutaneous fat. This systematic review and meta-analysis aimed to investigate the association between visceral adiposity, subcutaneous fat, and severe COVID-19. Methods: We performed a systematic literature search using the databases: PubMed, Embase, and EuropePMC. Data on visceral fat area (VTA), subcutaneous fat area (SFA), and total fat area (TFA) were collected. The outcome of interest was severe COVID-19. We used a REML random-effects model to pool the mean differences and odds ratio (OR). Results: There were 5 studies comprising of 539 patients. Patients with severe COVID-19 have a higher VTA (mean difference 41.7 cm2 [27.0, 56.4], p < 0.001; I2: 0%) and TFA (mean difference 64.6 cm2 [26.2, 103.1], p = 0.001; I2: 0%). There was no significant difference in terms of SFA between patients with severe and non-severe COVID-19 (mean difference 9.3 cm2 [-4.9, 23.4], p = 0.199; I2: 1.2%). Pooled ORs showed that VTA was associated with severe COVID-19 (OR 1.9 [1.1, 2.2], p = 0.002; I2: 49.3%). Conclusion: Visceral adiposity was associated with increased COVID-19 severity, while subcutaneous adiposity was not. Prospero id: CRD42020215876. © 2021 European Society for Clinical Nutrition and Metabolism |
Adiposity; Coronavirus; Obesity; Visceral fat; Visceral fat area |
Article; artificial ventilation; body composition; body mass; cardiovascular disease; coronavirus disease 2019; critical illness; diabetes mellitus; disease exacerbation; disease severity; human; hypertension; intensive care unit; intra-abdominal fat; meta analysis; mortality; Newcastle-Ottawa scale; nonhuman; obesity; observational study; respiratory tract intubation; Severe acute respiratory syndrome coronavirus 2; shock; subcutaneous fat; systematic review; abdominal obesity; aged; body mass; comorbidity; complication; female; intra-abdominal fat; male; metabolism; middle aged; severity of illness index; subcutaneous fat; Adiposity; Aged; Body Mass Index; Comorbidity; COVID-19; Female; Humans; Intra-Abdominal Fat; Male; Middle Aged; Obesity; Obesity, Abdominal; SARS-CoV-2; Severity of I |
Elsevier Ltd |
24054577 |
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34024509 |
Article |
Q2 |
659 |
7601 |
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|
386 |
Oike T., Uchihara Y., Permata T.B.M., Gondhowiardjo S., Ohno T., Shibata A. |
36453136000;57221723636;57197808751;6508327402;35395665700;8323572900; |
Quantitative volumetric analysis of the Golgi apparatus following X-ray irradiation by super-resolution 3D-SIM microscopy |
2021 |
Medical Molecular Morphology |
54 |
2 |
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166 |
172 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099941107&doi=10.1007%2fs00795-020-00277-z&partnerID=40&md5=67d2ba3ce4cc88d92e3e071747ee2f42 |
Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia |
Oike, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Uchihara, Y., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Permata, T.B.M., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Faculty of Medicine Universitas Indonesia-Dr. Cipto Mangunkusumo Hospital, Jl. P. Diponegoro No. 71, Jakarta, 10430, Indonesia; Ohno, T., Department of Radiation Oncology, Gunma University Graduate School of Medicine, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan, Gunma University Heavy Ion Medical Center, 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan; Shibata, A., Signal Transduction Program, Gunma University Initiative for Advanced Research (GIAR), 3-39-22, Showa-machi, Maebashi, Gunma 371-8511, Japan |
To obtain quantitative volumetric data for the Golgi apparatus after ionizing radiation (IR) using super-resolution three-dimensional structured illumination (3D-SIM) microscopy. Normal human retinal pigment epithelial (RPE) cells were irradiated with X-rays (10 Gy), followed by immunofluorescence staining of the Golgi marker RCAS1. 3D-SIM imaging was performed using DeltaVision OMX version 4 and SoftWoRx 6.1. Polygon rendering and spot signal identification were performed using Imaris 8.1.2. Differences between groups were assessed by Welch’s t test. RCAS1 signals in untreated cells were located adjacent to nuclei and showed a reticular morphology. Upon IR, the area of RCAS1 signals expanded while retaining the reticular morphology. Polygon rendering imaging revealed that the volume of RCAS1 at 48 h post-IR was greater than that for unirradiated cells (93.7 ± 19.0 μm3 vs. 33.0 ± 4.2 μm3, respectively; P < 0.001): a 2.8-fold increase. Spot signal imaging showed that the number of RCAS1 spot signals post-IR was greater than that for unirradiated cells [3.4 ± 0.8 (× 103) versus 1.3 ± 0.2 (× 103), respectively; P < 0.001]: a 2.7-fold increase. This is the first study to report quantitative volumetric data of the Golgi apparatus in response to IR using super-resolution 3D-SIM microscopy. © 2021, The Author(s). |
3D-SIM; Golgi; Ionizing radiation; RCAS1; Super-resolution microscopy |
article; controlled study; Golgi complex; human; human experiment; immunofluorescence; ionizing radiation; microscopy; quantitative analysis; retina pigment cell; signal transduction; vision; X irradiation; X ray; cell culture technique; epithelium cell; fluorescence microscopy; Golgi complex; procedures; radiation response; retina; three-dimensional imaging; ultrastructure; X ray; Cell Culture Techniques; Epithelial Cells; Golgi Apparatus; Humans; Imaging, Three-Dimensional; Microscopy, Fluorescence; Retina; X-Rays |
Springer Japan |
18601480 |
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33501611 |
Article |
Q2 |
650 |
7736 |
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