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301 |
Utami P.D., Hadi U., Dachlan Y.P., Suryokusumo G., Loeki Enggar Fitri R., Yudo V. |
57221766908;55804160500;6602868510;57205444996;57226796443;57226798501; |
Protection against brain histopathological damage in experimental cerebral malaria models after exposure to hyperbaric oxigent |
2021 |
Research Journal of Pharmacy and Technology |
14 |
7 |
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3833 |
3838 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112730263&doi=10.52711%2f0974-360X.2021.00665&partnerID=40&md5=1e7f971b7e62fc8286374b6c4e534dd9 |
Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
Utami, P.D., Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Hadi, U., Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Dachlan, Y.P., Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Suryokusumo, G., Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Loeki Enggar Fitri, R., Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Yudo, V., Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
In this study, brain damage caused by cerebral malaria was induced by parasitized erythrocyte rupture and sequestration, which led to inflammation and blood vessel damage. Therefore, this research objective to determine the effect of oxygen administration on the histopathological features and sequestration of CD3 lymphocyte T cells on Plasmodium berghei ANKA/PbA-infected vascular endothelial brain tissue of mice. The study samples consisted of 39 C57BL/6 mice, which were divided into 3 groups: G1 contained normal mice; G2 contained PbA-infected mice; G3 were mice infected with PbA, and administered HBO 2.4 ATA for 10 days straight. Histopathological examination of the of brain tissue and CD3 lymphocyte T cell expression was carried out using immuno-histochemical at the end of the study. Therefore, the results of this study indicate that HBO administration can reduce the level of parasites, can improve the histopathological features of the brain, and can reduce the sequestration of CD3 cells in the brain's blood vessels. According to the results, it can be concluded that 10 sessions of HBO 2.4 ATA exposure can reduce the level of parasites, enhance the histopathological features of brain tissue and decrease the sequestration of CD3 lymphocyte T cells. © RJPT All right reserved. |
CD3 cells; Cerebral malaria; Endothel; Histopathological; Hyperbaric oxygen |
CD3 antigen; cytotoxic T lymphocyte antigen 4; ketamine; reactive oxygen metabolite; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; blood smear; blood vessel injury; brain damage; brain protection; brain tissue; CD4+ T lymphocyte; CD8+ T lymphocyte; cell adhesion; cerebral malaria; consciousness; controlled study; endothelium; endothelium cell; erythrocyte count; female; gene expression; hematological parameters; histochemistry; histopathology; hyperbaric oxygen therapy; immunohistochemistry; inflammation; leukocyte count; malaria; mortality rate; neutrophil lymphocyte ratio; nonhuman; oxygen therapy; parasitemia; phagocytosis; Plasmodium berghei ANKA; protein expression; T lymphocyte |
Research Journal of Pharmacy and Technology |
09743618 |
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Article |
Q3 |
225 |
17916 |
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303 |
Samara T., Wibowo H., Liem I., Prijanti A., Andrijono A. |
57208256339;57217690943;55802927800;57190863386;57208264133; |
Cullin 1 as a proangiogenic factor and its relationship with vascular endothelial growth factor and p21 are associated with the length of gestational age of pre-eclampsia |
2021 |
Journal of Natural Science, Biology and Medicine |
12 |
2 |
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140 |
144 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111296351&doi=10.4103%2fjnsbm.JNSBM-123-20&partnerID=40&md5=10efc582ba2ed72d7813100c2ebbc2d5 |
Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Samara, T., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Wibowo, H., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Liem, I., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Anatomy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Prijanti, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andrijono, A., Department of Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: Cullin 1 (CUL1), vascular endothelial growth factor (VEGF), and p21 are proteins that play a role in pregnancy. CUL1 and VEGF are proangiogenic factors, whereas p21 is an antiangiogenic factor. An imbalance between proangiogenic and antiangiogenic factors is one of the various factors that cause pre-eclampsia (PE). The aim of this study was to analyze CUL1 levels in the relationship with VEGF levels and p21 levels based on gestational age at delivery in PE. Materials and Methods: This was a cross-sectional study of 70 placentas from PE patients divided in two groups of gestational age at delivery: <34 weeks and ≥34 weeks. Levels of CUL1, VEGF, and p21 were examined by the enzyme-linked immunosorbent assay technique. Statistical analysis was assessed by Spearman correlation test and Chi-square test, with a significant P < 0.05. Results: Low levels of CUL1 and low levels of VEGF were related with <34 weeks of gestational age at delivery, whereas high levels of CUL1 and high levels VEGF were related with ≥34 weeks of gestational age at delivery. There was a negative correlation between the high ratios of p21/CUL1 and <34 weeks of gestational age at delivery in PE. Conclusions: Low levels of CUL1 and low levels VEGF and high ratios of p21/CUL1 were associated with <34 weeks of gestational age at delivery in PE. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Cullin 1; gestational age; p21; pre-eclampsia; vascular endothelial growth factor |
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Wolters Kluwer Medknow Publications |
09769668 |
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Article |
Q3 |
236 |
17374 |
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305 |
Firdaus M.D., Artanti N., Hanafi M., Rosmalena |
57226243708;14832374300;26644895300;56891769500; |
Phytochemical constituents, and in vitro antidiabetic and antioxidant properties of various extracts of kenikir (cosmos caudatus) leaves |
2021 |
Pharmacognosy Journal |
13 |
4 |
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890 |
895 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110937044&doi=10.5530%2fpj.2021.13.114&partnerID=40&md5=90452554ceab08be4e58b8af98f14dc7 |
Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia |
Firdaus, M.D., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Artanti, N., Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia; Hanafi, M., Research Center for Chemistry, Indonesian Institute of Sciences, Kawasan PUSPITEK, Serpong, Banten, South Tangerang, Indonesia; Rosmalena, Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Type 2 diabetes mellitus (T2DM) is one of the most common degenerative disorders. For therapeutic use, herbs are commonly used in Indonesia for T2DM treatment, one of them is (Cosmos caudatus) kenikir's leaves. In previous studies, kenikir's leaves have high antidiabetic and antioxidant activity. However, a comparison of antidiabetic activity from many extracts of kenikir's leave is remain unclear. This study will compare the antidiabetic and antioxidant properties of various kenikir's leave extract. Kenikir's leaves are extracted by maceration methods for three days using three different solvents: boiling water, 50% ethanol, dan ethanol 100%.Then, phenolic and flavonoid content will be measured, as well as antioxidant properties by DPPH radical scavenging activity assay, and antidiabetic properties by α-glucosidase inhibition assay, also LCMS/MS will be used to predict the compound from each extract. The result shows that 50% ethanol extract has highest phenolic and flavonoid content than others. It also has significantly higher antioxidant (p<0.05) and antidiabetic (p<0.05) properties than others. Meanwhile, LCMS/MS result of 50% ethanol extract predicts 6 chemical component, that quercetin is the most dominant compound. 50% ethanol extract of kenikir's leaves is superior from other extracts on phenolic and flavonoid content, antioxidant properties, and antidiabetic properties. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
α-Glucosidase |
1,1 diphenyl 2 picrylhydrazyl; 2 beta 3 beta dihydroxy nortropane; alcohol; alpha glucosidase; antidiabetic agent; antioxidant; Cosmos caudatus extract; delta humulene; digiprolactone; flavonoid; genistin; gentiatibetine; glucopyranoside; herbaceous agent; oroxin B; phenol; phenylproprionic acid; phytochemical; plant extract; quercetin; solvent; spathulenol; stearidonic acid; unclassified drug; valine; water; antidiabetic activity; antioxidant activity; Article; boiling point; controlled study; Cosmos (genus); DPPH radical scavenging assay; human; in vitro study; Kenikir leaf; liquid chromatography-mass spectrometry; nonhuman; plant leaf |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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306 |
Rosmalena, Widyastuti P.A., Yazid F., Ambarwati N.S.S., Ahmad I. |
56891769500;57226249984;57207890516;57193830343;57190669391; |
Phytochemicals and antioxidant activities evaluation of origanum vulgare (L.) stem bark extracts |
2021 |
Pharmacognosy Journal |
13 |
4 |
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965 |
970 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110932652&doi=10.5530%2fpj.2021.13.124&partnerID=40&md5=01f50c35c8a94d648081fcd99e50d8fa |
Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia |
Rosmalena, Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Widyastuti, P.A., Medical Student, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Yazid, F., Department of Medical Chemistry, Faculty of Medicine, Universitas Indonesia, South Jakarta, Jakarta, 10430, Indonesia; Ambarwati, N.S.S., Department of Cosmetology, Faculty of Engineering, Universitas Negeri Jakarta, East Jakarta, Jakarta, 13220, Indonesia; Ahmad, I., Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Mulawarman, East Kalimantan, Samarinda, 75119, Indonesia |
The present study aimed to evaluate phytochemical and antioxidant activity (in vitro and in vivo) of Origanum vulgare (L.) ethanolic extract. The phytochemical test was assessed using the Clule method in ethanol, ethyl acetate, and hexane. In vitro evaluation of antioxidant activity was determined by radical scavenging assay using DPPH (2,2-diphenyl-1-picrylhydrazyl) as an artificial free radical activity. In vivo test was conducted to evaluate the effect of malondialdehyde (MDA) level in blood plasma during maximum physical activity treatment. In vivo test was done using 25 male Sprague Dawley rats in pre and post-test control group design. The phytochemical test of O. vulgare ethanol extract was showed some compounds, such as a flavonoid, alkaloid, triterpenoid/steroid, essential oil, and tannin, then in ethyl acetate and hexane. In vitro assay showed that O. vulgare extract has strong antioxidant activity with an IC50 value of 133.47 µg/mL. While in the in vivo test, the most effective dosage is 20 mg/200 gr B.W., represented by a significant decrease of MDA level (0.509 nmol/mL) before and after treatment. So, the ethanolic extract of clove has potency as an herbal antioxidant because of the low level of IC50 and can decrease the MDA level. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
2; 2-diphenyl-1-picrylhydrazyl; Antioxidant activity; Malondialdehyde; Origanum vulgare (L.); Phytochemical |
1,1 diphenyl 2 picrylhydrazyl; acetic acid ethyl ester; alcohol; alkaloid; antioxidant; ascorbic acid; essential oil; flavonoid; free radical; hexane; malonaldehyde; Origanum vulgare ethanolic extract; phytochemical; plant extract; saponin; steroid; tannin; triterpenoid; unclassified drug; animal experiment; animal tissue; antioxidant activity; Article; bark; blood sampling; clove; controlled study; DPPH radical scavenging assay; drug potency; in vitro study; in vivo study; male; nonhuman; physical activity; pretest posttest design; rat; Sprague Dawley rat |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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310 |
Situmorang H., Hestiantoro A., Purbadi S., Flamandita D., Sahlan M. |
57195939562;8743255100;6505677307;57216766308;57189182661; |
IN-SILICO dynamic analysis of Sulawesi propolis as anti-endometriosis drug: Interaction study with TNF alpha receptor, NF-kB, estrogen receptor, progesterone receptor and prostaglandin receptor |
2021 |
Annals of Medicine and Surgery |
67 |
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102459 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109547312&doi=10.1016%2fj.amsu.2021.102459&partnerID=40&md5=0f7d6fdeda084de97c22a80f60f7b2a7 |
Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Situmorang, H., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Hestiantoro, A., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Purbadi, S., Department of Obstetrics and Gynecology Faculty of Medicine Universitas Indonesia – Dr Cipto Mangunkusumo National Referral Hospital, Jl. Salemba Raya No. 6, Central Jakarta, Jakarta Capital Special Region 10430, Indonesia; Flamandita, D., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia; Sahlan, M., Department of Chemical Engineering, Faculty of Engineering, Universitas Indonesia, Jl. Fuad Hasan, Pancoran MAS, Kukusan, Beji, Depok City, West Java 16424, Indonesia |
Introduction: Endometriosis is a disease that impacts around 10% of all women in reproductive age, with pelvic pain and infertility as its main clinical features. Current medical treatment targeting lowering estrogen activity has not shown sufficient result due its side effects and reproductive function suppression. Propolis has been widely studied, showing anti inflammation and pro-apoptosis property, that could potentially be used in the treatment of endometriosis. This study investigates the interaction between Sulawesi Propolis’ active components and receptors and protein related to endometriosis pathogenesis. Methods: Active components of Sulawesi Propolis were initially identified with their targeted protein receptors. Lipinski rules were used to screen potential components. The ligands and proteins were tested using Autodock program to predict the most active compound and possible binding sites between propolis and some target proteins associated with inflammatory and apoptotic activity in endometriosis models. Receptor modelling is then performed using Swiss-Model. Results: These active components of Sulawesi Propolis showed a strong binding potential towards TNF- α, NF-kb, Estrogen-α, Estrogen-β, progesterone B, PGE2 EP2 and EP3 subtype respectively: Sanggenon C, Sanggenon H, Epicryptoacetalide, Chrysin-7-O-β-D-glucopyranodside, Irilone, Polydatin and Epicryptoacetalide. Compared to its negative ligand, Sulawesi Propolis displayed a stronger binding capacity to TNF-α, Estrogen-α, and Progesterone B receptors. Conclusion: Sulawesi Propolis has the ability to interact with receptors related to reproductive function, apoptotic reactions and inflammatory processes, a significant factor associated with the pathogenesis of endometriosis. © 2021 |
Docking; Endometriosis; Estrogen receptor; In silico; NF-kB; Progesterone receptor; Propolis; Prostaglandin receptor; TNF alpha Receptor |
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Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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312 |
Mantiri B.J., Sigumonrong Y. |
57211646737;57209291346; |
Bilateral adrenal tumor: A case report and current challenges |
2021 |
International Journal of Surgery Case Reports |
84 |
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106134 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109442036&doi=10.1016%2fj.ijscr.2021.106134&partnerID=40&md5=6e73ca95877115564bd2d8829933ec42 |
Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Mantiri, B.J., Urology Resident of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia; Sigumonrong, Y., Urology Consultant of Urology Department, Faculty of Medicine, Universitas Indonesia - H. Adam Malik Hospital, Medan, Indonesia |
Introduction: A bilateral adrenal tumor is a rare case. It differs significantly from unilateral adrenal mass since it is related strongly to genetic and family history. Adrenocortical Carcinoma might cause related hormonal syndromes such as Cushing syndrome, Conn syndrome, and virilization. Aim: This study aims to report an uncommon presentation of a 15-year-old female with bilateral Adrenal Tumor since an early age with virilization as the main symptoms. Case presentation: The patient is a 15-year-old girl with female genitalia presentation. She complained of a bulging mass on her right flank with pain four years ago. The mass size grew progressively and initially painless. However, the patient started to feel pain a year ago. Since she was six years old, the mass started to appear on the left flank, and then it also started to appear on the right side. The mass appearance is simultaneous with virilization symptom development, such as the emergence of facial hair, mustache, and sideburns. In 2020, MRI showed a lesion on the right suprarenal with contrast enhancement with 14.5 × 11.5 cm in size, and a 5.6 × 4 cm recurrent left suprarenal lesion. The patient underwent right adrenalectomy resection surgery on January 21st, 2021. The immunohistochemistry examination suggested Adrenocortical Carcinoma. Conclusion: Adrenocortical Carcinoma is a hormone-secreting tumor that might affect the patient's condition systematically. Neglected cases of adrenal cortical carcinoma might affect secondary sexual organ development in the long term. Thus, an early diagnosis and treatment are paramount for this case. © 2021 |
Adrenalectomy; Bilateral adrenocortical carcinoma; Virilization |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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313 |
Rahayatri T.H., Amaliah R., Putri N.M., Puspaningtyas N.W., Karyanti M.R., Hendarto A. |
57188549965;57224001785;57192904294;57223288515;56290680800;57204142249; |
Omphalopagus conjoined twins separation during coronavirus disease-19 pandemic era: A case report |
2021 |
International Journal of Surgery Case Reports |
84 |
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106150 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109424878&doi=10.1016%2fj.ijscr.2021.106150&partnerID=40&md5=a376a2af0ee2eeb9a9da557e67166686 |
Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Plastic Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Intensive Care Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Infectious and Tropical Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Pediatric Nutrition and Metabolic Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Rahayatri, T.H., Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Amaliah, R., Faculty of Medicine, Universitas Indonesia, Pediatric Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Putri, N.M., Faculty of Medicine, Universitas Indonesia, Plastic Surgery Division, Department of Surgery, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Puspaningtyas, N.W., Faculty of Medicine, Universitas Indonesia, Pediatric Intensive Care Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Karyanti, M.R., Faculty of Medicine, Universitas Indonesia, Pediatric Infectious and Tropical Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hendarto, A., Faculty of Medicine, Universitas Indonesia, Pediatric Nutrition and Metabolic Disease Division, Department of Child Health, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction and importance: Conjoined twin is a rare congenital anomaly characterized by a fusion of certain anatomical structures. Coronavirus-19 (COVID-19) is a new emerging infectious respiratory disease affecting worldwide and potentially leads to acute respiratory distress (ARDS) in children. COVID-19 has reconstructed the healthcare system, including surgical care and decision-making. Case presentation: Herein we describe a surgical separation of 2.5 months old omphalopagus conjoined twins, with one of them (Baby A) presenting COVID-19-associated respiratory distress, as well as the challenges faced during the preparation and the execution of the complex surgical procedure. Clinical discussion: Baby A underwent antiviral therapy, oxygen supplementation, and ventilation in the ICU, while baby B remained stable and confirmed negative for SARS-CoV-2. The separation surgery was conducted after baby A had become clinically stable. Defect closure and reconstruction were accomplished. At one week follow-up, Baby A died of lung infection, while baby B remained well after one year. Conclusion: The complexity of surgical separation requires careful planning by a multidisciplinary team. Surgical separation of conjoined twins during the pandemic era has not been reported much in the literature, more reports are required to provide further insight. © 2021 The Authors |
Case report; Children; Conjoined twins separation; COVID-19; Omphalopagus conjoined twins |
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Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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314 |
Kreshanti P., Putri N.T., Martin V.J., Sukasah C.L. |
36192866200;57192904294;57221635093;57218391534; |
The effectiveness of oral propranolol for infantile hemangioma on the head and neck region: A case series |
2021 |
International Journal of Surgery Case Reports |
84 |
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106120 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109354279&doi=10.1016%2fj.ijscr.2021.106120&partnerID=40&md5=d7e0ac8c9d5ad4046f2b8c78dc622412 |
Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kreshanti, P., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Putri, N.T., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Martin, V.J., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sukasah, C.L., Plastic Reconstructive and Aesthetic Surgery Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Introduction: Infantile hemangioma is the most common tumor in infancy, with 60% occurring on the face and neck. A large tumor involving the facial region will cause significant aesthetic and functional impairment and isn't always easy to treat surgically. A non-invasive treatment is needed for this condition. Propranolol has recently been used as a choice of treatment in infantile hemangioma. Presentation of case: We presented two cases of large problematic infantile hemangioma that were successfully managed with oral propranolol. Discussion: Large problematic lesions that ulcerate and bleed often need surgery; however, a substantial defect resulting from surgery is tricky to reconstruct and can cause significant scar. Propranolol is used because of its efficacy and low risk characteristics. Conclusion: Propranolol is an effective treatment to reduce the need of surgical intervention in problematic hemangioma. © 2021 The Authors |
Case report; Infantile hemangioma; Propranolol; Surgery |
eye ointment; gentamicin; propranolol; blood pressure monitoring; capillary hemangioma; case report; cheek; child; clinical article; clinical effectiveness; clinical feature; dermatologist; drug dose increase; drug efficacy; ecchymosis; eye protection; eyelid; female; head and neck disease; heart rate measurement; human; lung function test; male; neoplasm; ophthalmologist; palpation; patient referral; preschool child; risk; Short Survey; skin color; skin ulcer; tumor volume |
Elsevier Ltd |
22102612 |
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Short Survey |
Q3 |
232 |
17549 |
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316 |
Widodo D.W., Dewi D.J., Ranakusuma R.W., Irawati Y. |
56644646600;57219323765;57189729404;57201260313; |
Evaluation of 3 and 2-point internal fixation in the management of zygomaticomaxillary complex fractures: Case report |
2021 |
Annals of Medicine and Surgery |
67 |
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102539 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109176909&doi=10.1016%2fj.amsu.2021.102539&partnerID=40&md5=aa5581548a2394f973a5958f289f0999 |
Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Widodo, D.W., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Dewi, D.J., Department of Otorhinolaryngology, Head and Neck Surgery, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ranakusuma, R.W., Clinical Epidemiology and Evidence-Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Irawati, Y., Department of Ophthalmology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: The ZMC has a prominent shape compared to other parts in the midfacial region, thus small injuries will generate fractures in the ZMC. The management of ZMC fracture depends on the fracture deformity and the surgeon's considerations. Various studies have revealed the success of ZMC reconstruction with one fixation point to 4 fixation points fitting to the tetrapod shape. Case report: We report two cases of ZMC fractures which comparing the efficacy of 3- and 2-point internal fixations for improving clinical outcomes The first patient underwent ORIF which placed at 2 fixation points, the first point in the left ZF suture and the second point in the left ZMB. The second patient underwent ORIF reconstruction at 3 fixation points, the first point in the right inferior orbital rim, the second point in the right ZF suture, and the third point in the right ZMB. Discussion: The most common surgical approach for ZMC fractures is through a gingivobuccal groin incision. This approach is for body exposure of the ZMB, which is the main buttress. The 3-point internal fixation improved the postoperative clinical outcome of fracture fragment stability compared to two-point fixation, but the mean malar height projection, vertical dystopia, and enophthalmos were not different between the two fixation methods. Conclusion: Three-point internal fixation can improve the clinical outcome of fracture fragment stability compared to 2-point fixation; however, it has a mean operative duration 22.2 minutes longer than 2-point fixation, so its application must be considered during the COVID-19 pandemic. © 2021 The Authors |
Case report; Internal fixation; Zygomatic fracture; Zygomaticomaxillary fracture |
adult; Article; cartilage graft; case report; clinical article; comparative effectiveness; computer assisted tomography; coronavirus disease 2019; endotracheal intubation; enophthalmos; female; general anesthesia; heterotopia; human; inguinal region; maxilla fracture; maxillofacial surgery; nose cavity; open fracture reduction; osteosynthesis; pandemic; physical examination; visual acuity; zygoma arch fracture |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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317 |
Hutauruk S.M., Hermani B., Monasari P. |
57205105620;14325051100;57224812004; |
Role of chlorhexidine on tracheostomy cannula decontamination in relation to the growth of Biofilm-Forming Bacteria Colony- a randomized controlled trial study |
2021 |
Annals of Medicine and Surgery |
67 |
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102491 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108345034&doi=10.1016%2fj.amsu.2021.102491&partnerID=40&md5=a3d916bc24eff149d6342e51ea55083d |
ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Hutauruk, S.M., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Hermani, B., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia; Monasari, P., ENT-Head and Neck Department, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Hospital, Jalan Diponegoro No. 71, Jakarta Pusat, Jakarta, 10430, Indonesia |
Background: Regular cleaning of the cannula in the trachea is very important for infection prevention. How to wash the tracheal cannula which is good to reduce the possibility of colonies of biofilm-forming bacteria and the growth of bacterial and the pattern of bacterial on the tracheal cannula is still unknown. This study aims to evaluate the efficacy of decontamination of the tracheal cannula using chlorhexidine and NaCl 0.9% in patients using the tracheal cannula to decrease biofilm-forming bacterial colony. Methods: 40 subjects were grouped into 20 subjects in the control group washing the cannula using 0.9% NaCl and the interventional group washing cannula using and with 2.5% chlorhexidine solution and 0.9% NaCl. This study used a parallel randomized controlled trial of 2 groups with a single blinded. Results: 40 subjects studied, 17 subjects (85%) each group produced biofilm-forming bacteria prior to intervention. After intervention in the study group, 15 subjects were biofilm negative and 5 biofilm positive subjects p = 0.001. The most common bacteria found in the control group is Pseudomonas aeruginosa, while in the study group some bacteria such as Acinetobacter sp. and Proteus mirabilis. Amoxicilin-Clavulanate had the highest resistance to biofilm forming bacteria in both groups. Piperacillin, ceftazidime, ciprofloxacin and meropenem have the highest sensitivity to biofilm-forming bacteria. Conclusion: There was a significant decrease in the number of colonies that produced biofilm in the tracheal cannula in the study group compared to the control group in tracheal cannula washing. © 2021 The Authors |
Bacteria colony; Biofilms; Chlorhexidine; Tracheostomy cannulae |
amoxicillin plus clavulanic acid; ceftazidime; chlorhexidine; ciprofloxacin; meropenem; piperacillin; sultamicillin; adult; aged; antibacterial activity; antibiotic resistance; Article; bacterial growth; bacterium colony; biofilm; clinical article; controlled study; decontamination; diabetes mellitus; Escherichia coli; human; hypertension; malnutrition; Proteus mirabilis; Pseudomonas aeruginosa; randomized controlled trial; single blind procedure; Staphylococcus aureus; tracheostomy |
Elsevier Ltd |
20490801 |
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Article |
Q3 |
391 |
12334 |
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