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415 |
Moegni F., Hakim S., Hidayah G.N., Suskhan, Priyatini T., Meutia A.P., Santoso B.I. |
55450456100;57192276095;57222671850;57222669994;57192265423;57203368133;56653822500; |
Cervical elongation caused by big cervical fibroid resembling malignant cervical prolapse? Management via vaginal surgery |
2021 |
International Journal of Surgery Case Reports |
82 |
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105847 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103699159&doi=10.1016%2fj.ijscr.2021.105847&partnerID=40&md5=a743d245c32a335e6a80121129df706c |
Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Moegni, F., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hakim, S., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Hidayah, G.N., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suskhan, Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Priyatini, T., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Meutia, A.P., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Santoso, B.I., Urogynecology Division Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Cervical elongation could lead to cervical elongation thus worsen the descent of uterine prolapse. In certain cases, this hypertrophic and hyperplastic mass could have fragile surface with some bleeding and necrotic, resembling cervical cancer. As case of cervical elongation due to cervical fibroid is quite rare, such cases are valuable to be reported. We present two cases of cervical fibroid with cervical elongation resembling cervical malignancy. Presentation of case: First case was A 59-year-old lady with intractable vaginal mass since one day before admission. Bleeding from the mass was positive. We found a bulky vaginal mass exceeding hymenal ring, 14 × 7 × 6 cm sized, with some necrotic and discharge, foul smelling, and some bleeding area. Ultrasound evaluation revealed a cervical fibroid with differential diagnosis cervical malignancy. The second case was Mrs 53-year-old with vaginal mass since last year. For the last 7 months the mass has been bigger and could not be inserted into vagina, with some bleeding. We found globular vaginal mass 12 × 9 × 6 cm exceeding hymenal ring, with some necrotic and reddish surface, foul smelling, discharge, and some blood. Ultrasound evaluation revealed cervical mass on anterior lip with elongated cervices. Both cases have been menopaused. As the clinical presentation resembling malignancy, we did biopsy. The biopsy results were no evidence of malignancy, then we did Manchester fothergill, and colporaphy as needed. Discussion: Length between internal to external cervical ostium ≥ 5 cm correlated to cervical elongation. Growing cervical mass could drag the cervix, predisposing to cervical elongation and prolapse. Cervical fibroids protruded through vagina was usually pedunculated. But in our cases, the fibroids were not pedunculated but manifested as a bulky mass on the cervical tissue with some bleeding and necrotics, mimicking cervical malignancy. The most important initial management besides ultrasound evaluation was mass biopsy. Conclusion: In such cervical fibroids with cervical elongation resembling cervical malignancy, biopsy is compulsory to determine the diagnosis and to lead the management. © 2021 The Authors |
Cervical cancer; Cervical elongation; Fibroids; Manchester |
adult; anemia; anterior vaginal wall prolapse; case report; cervical elongation; cervical fibroid; cervical length; chronic inflammation; clinical article; clinical outcome; dissection; echography; emergency ward; endometrial thickness; endomyometritis; female; follow up; gynecologic surgery; histopathology; human; human tissue; incision; middle aged; necrosis; posterior vaginal wall prolapse; priority journal; Short Survey; surgical wound; tachycardia; uterine cervix biopsy; uterine cervix disease; vagina bleeding; vagina discharge (disease); vagina reconstruction; wound healing |
Elsevier Ltd |
22102612 |
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Short Survey |
Q3 |
232 |
17549 |
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416 |
Irawati Y., Fitri M.A.R., Natalia M.E.R., Atmodiwirjo P., Ramadan M.R., Triatmoko S.E. |
57201260313;57222671166;57222668119;57222670453;57222667572;57222671805; |
A case report of reconstruction of ocular and complete upper eyelid avulsion with severe facial soft tissue injuries using anterolateral thigh free flap |
2021 |
International Journal of Surgery Case Reports |
82 |
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105856 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103698401&doi=10.1016%2fj.ijscr.2021.105856&partnerID=40&md5=af73a4517bc594c3298dc3cd1272efe3 |
Plastic Reconstructive Surgery Division, Ophthalmology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Ophthalmology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Irawati, Y., Plastic Reconstructive Surgery Division, Ophthalmology Department, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Fitri, M.A.R., Ophthalmology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Natalia, M.E.R., Ophthalmology Department, Faculty of Medicine Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Atmodiwirjo, P., Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Ramadan, M.R., Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Triatmoko, S.E., Reconstructive Microsurgery Section, Division of Plastic Surgery, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Introduction and importance: Ocular injury is second mostly caused by motor vehicle accident (MVA) and often leads to severe ocular injury even to visual loss and various aesthetic problems. The outcome is determined by the magnitude of the initial damage and treatment availability. Treating ocular and facial injury due to MVA is challenging given the scope of the damage and may result in various outcomes. Case presentation: This case presented a 22-years old woman with a history of car accident assessed with total upper eyelid avulsion with corneal perforation and involvement of multiple facial fractures on the left side. The visual function is irreparable due to the extensive corneal defect from exposure and secondary infection, and possible optic nerve damage. Clinical discussion: This case presented a complete upper eyelid avulsion with severe facial tissue injury. Therefore, the reconstructive procedure main objectives are to maintain appropriate prosthetic position and to improve cosmetic function. This case used anterolateral thigh free flap as the reconstructive surgery method because it is convenient for large defects and the donor scar is not visible. After completing the surgery and several follow-up procedures, the patient recovered without any significant complications. Conclusion: Despite visual loss due to the extent damage of the eye, it is important to restore the facial damages. Visual function is as crucial as cosmetic function in determining the patient's quality of life. © 2021 |
Anterolateral thigh free flap; Case report; Ocular injury; Surgical intervention; Upper eyelid avulsion |
abscess; adult; anterolateral thigh flap; Article; avulsion injury; bulbar conjunctiva; canthopexy; case report; chemosis; clinical article; collaborative care team; computer assisted tomography; conjunctival hyperemia; convalescence; cornea perforation; corneal abscess; ectropion; esthetic surgery; esthetics; eye evisceration; eye examination; eye injury; eye surgery; eyelid disease; eyelid reconstruction; face fracture; face injury; female; hair transplantation; horizontal palpebral fissure; human; injury severity; keratitis; lagophthalmos; liposuction; multiple fracture; palpebral fissure; patient referral; patient safety; patient satisfaction; plastic surgeon; priority journal; pus; socialization; soft tissue injury; suture technique; three-dimensional imaging; tissue necrosis; total q |
Elsevier Ltd |
22102612 |
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Article |
Q3 |
232 |
17549 |
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420 |
Sunarno, Khariri, Muna F., Sariadji K., Rukminiati Y., Febriyana D., Febrianti T., Saraswati R.D., Susanti I., Puspandari N., Karuniawati A., Malik A., Soebandrio A. |
57222956230;57222528104;57218911032;57199654249;57214868942;57222530233;57222528085;57214871905;57222520009;56786591900;54886816200;35079198800;8602893200; |
New approach for the identification of potentially toxigenic Corynebacterium sp. using a multiplex PCR assay |
2021 |
Journal of Microbiological Methods |
184 |
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106198 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103000221&doi=10.1016%2fj.mimet.2021.106198&partnerID=40&md5=3183ff3090d2d560fdf7771ab93c7a66 |
Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Microbiology and Biotechnology Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Sunarno, Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Khariri, Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Muna, F., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Sariadji, K., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Rukminiati, Y., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Febriyana, D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Febrianti, T., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Saraswati, R.D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Susanti, I., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia; Karuniawati, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Malik, A., Division of Microbiology and Biotechnology Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, Indonesia; Soebandrio, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
In diphtheria laboratory examinations, the PCR test can be applied to isolates and clinical specimens. This study aimed to develop a PCR assay to identify the species and toxigenicity of diphtheria-causing bacteria, including the prediction of some NTTB types. Seven reference isolates, four synthetic DNA samples, 36 stored isolates, and 487 clinical samples used for PCR optimization. The PCR results was confirmed by DNA sequence analysis. The results of the PCR examination of the 7 reference isolates and 36 stored isolates were similar to the results obtained using conventional methods as gold standard, both for diphtheria-causing and non-diphtheria-causing bacteria. The validation of the PCR results using DNA sequence analysis showed that there was no mispriming or misamplification. The multiplex PCR assay developed in this study could correctly identify the species and toxigenicity of diphtheria-causing bacteria, including the prediction of some NTTB types not yet covered by established PCR methods. © 2021 Elsevier B.V. |
Diphtheria; dtxR gene; PCR; Potentially toxigenic Corynebacterium |
Article; bacterial gene; bacterium identification; controlled study; Corynebacterium; diphtheria; DNA sequence; dtxR gene; gold standard; multiplex polymerase chain reaction; nonhuman; priority journal; bacterium identification; classification; Corynebacterium; Corynebacterium infection; genetics; human; isolation and purification; microbiology; multiplex polymerase chain reaction; procedures; bacterial protein; primer DNA; Bacterial Proteins; Bacterial Typing Techniques; Corynebacterium; Corynebacterium Infections; Diphtheria; DNA Primers; Humans; Multiplex Polymerase Chain Reaction |
Elsevier B.V. |
01677012 |
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33713727 |
Article |
Q3 |
629 |
8028 |
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422 |
Putra M.D., Rahyussalim A.J., Jusman S.W.A., Iswanti F.C., Sadikin M. |
57221617403;55212166100;36518792100;57192920851;36981411100; |
Phagocytosis and the antigen-processing abilities of macrophages derived from monocytes in spinal tuberculosis patients |
2021 |
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
23 |
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100215 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099630069&doi=10.1016%2fj.jctube.2021.100215&partnerID=40&md5=2548fbe746aaf9e6e815fb1375351254 |
Master's Program in Biomedical Science, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia10430, Indonesia; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta15419, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Indonesia |
Putra, M.D., Master's Program in Biomedical Science, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta15419, Indonesia; Rahyussalim, A.J., Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital10430, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia; Iswanti, F.C., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia |
This study examined the hypothesis that there is an impairment of macrophageal function in spinal TB. We examined macrophageal functions in spinal TB patients. Monocytes were isolated from peripheral blood mononuclear cells (PBMCs) of five spinal TB patients and five healthy persons as control. The isolated monocytes were cultured with stimulation of macrophage colony-stimulating factor (M-CSF) for seven days for maturation. The phagocytic ability of the macrophages derived from monocytes was measured. Also, nitric oxide (NO), myeloperoxidase (MPO), beta-glucuronide, and acid phosphatase activity was investigated. We found that the monocytes collected from patient PBMCs were significantly fewer than those of the control group (2992.103 vs. 6474.103 (cells/mL)). There were also fewer macrophages that had adhered to sheep red blood cells (SRBC) (598.103 vs. 264.103 (cells/mL)). However, NO production (2346 vs. 325.17 (µmol/gram of protein)), and the MPO (570.7 vs. 17.4 (unit/mg), beta-glucuronide (0.149 vs. 0.123 (μmol/hour/100 mg of protein)), and acid phosphatase activities (1776.9 vs. 287.9 (μmol/hour/100 mg of protein)) of the macrophages in the spinal TB group were markedly higher than in the healthy group. Despite the low adhesion to foreign bodies, the intracellular processing of TB macrophages, including oxidative activity and lysosome function, was significantly high. These results suggested the impairment of macrophageal function in spinal TB. Possibly, there is a dominance of innate non-specific immunity in spinal TB infection. © 2021 The Author(s) |
Acid phosphatase; Beta-glucuronidase; Macrophage; Myeloperoxidase; Nitric oxide; Spinal tuberculosis |
acid phosphatase; beta glucuronidase; colony stimulating factor 1; glucuronide; myeloperoxidase; nitric oxide; adult; antigen presentation; Article; cell adhesion; cell maturation; clinical article; controlled study; enzyme activity; female; foreign body; human; human cell; lysosome; macrophage; macrophage culture; macrophage function; male; monocyte; oxidation; phagocytosis; priority journal; sheep erythrocyte; tuberculous spondylitis |
Elsevier Ltd |
24055794 |
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Article |
Q3 |
585 |
8643 |
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424 |
Satjakoesoemah A.I., Situmorang G.R., Wahyudi I., Rodjani A. |
57189614677;57190001213;36341995300;6504653529; |
Single-stage urethroplasty: An eight-year single-centre experience and its associated factors for urethrocutaneous fistula |
2021 |
Journal of Clinical Urology |
14 |
3 |
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190 |
195 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85088243456&doi=10.1177%2f2051415820941746&partnerID=40&md5=9a30aabea7f642db31b4abbbd426894e |
Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Satjakoesoemah, A.I., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Situmorang, G.R., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Wahyudi, I., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rodjani, A., Department of Urology, Cipto Mangunkusumo General Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Introduction: This study aimed to describe single-stage urethroplasty and to determine factors associated with urethrocutaneous fistula after the procedure at our institution. Methods: All hypospadias patients without any prior surgery who underwent single-stage urethroplasty from July 2010 to January 2018 were included. In total, 179 patients were followed for at least one year postoperatively. Information on types of hypospadias, operation techniques, chordee degree, preoperative pyuria (urine white blood cell count >5/HPF), urethral defect length and urethrocutaneous fistula formation was collected. Results: We obtained 103 cases of posterior (57.5%), middle (57 cases) and anterior (19 cases) hypospadias on whom onlay preputial island flap (71 cases), tubularized incised plate (46 cases) and Duckett’s transverse preputial island flap (35 cases) were conducted. After 47.1±25.8 months of follow-up, urethrocutaneous fistula were found in 23 (12.8%) patients associated with posterior hypospadias occurrence (p=0.025), longer urethral defect (p=0.007) and preoperative pyuria (p<0.001). Chordee degree (p=0.886) and age (p=0.187) were not significant factors associated with urethrocutaneous fistula formation. Conclusion: Single-stage urethroplasty is a versatile procedure for various hypospadias cases, with a urethrocutaneous fistula rate of 12.8%. Posterior hypospadias, preoperative pyuria and longer urethral defect were associated with urethrocutaneous fistula formation. Level of evidence: Level 2B. © British Association of Urological Surgeons 2020. |
hypospadias; risk factors; Single stage; single-centre experience; urethrocutaneous fistula; urethroplasty |
cefoperazone; cefotaxime; chloramphenicol; adolescent; adult; Article; child; chordee; cohort analysis; cystostomy; follow up; human; hypospadias; infant; island flap; leukocyturia; major clinical study; male; operation duration; preoperative evaluation; pyuria; renal system parameters; retrospective study; skin fistula; ureter fistula; urethral defect length; urethroplasty; urinary tract infection |
SAGE Publications Ltd |
20514158 |
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Article |
Q3 |
192 |
19868 |
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430 |
Mariati N.M.A.S., Sugiarto A., Endriani E., Lestari R., Anindita K. |
57223228784;57189612291;57222314378;57223220725;57192903786; |
High flow nasal cannula to prevent intubation in obese patient with COVID-19 induced ARDS: a case report |
2021 |
Anaesthesia, Pain and Intensive Care |
25 |
2 |
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212 |
216 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105281913&doi=10.35975%2fAPIC.V25I2.1473&partnerID=40&md5=2108db369e86e24a12b1ed89d9a0970b |
Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Mariati, N.M.A.S., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sugiarto, A., Department of Anesthesiology & Intensive Care, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Endriani, E., Department of Anesthesiology & Intensive Care, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Lestari, R., Pulmonology Department, Faculty of Medicine, University of Mataram-West Nusa Tenggara General Hospital, Lombok, Indonesia; Anindita, K., Department of Internal Medicine, Siloam Hospitals Mataram, Jl. Majapahit, Pagesangan, Kec. Mataram, Kota Mataram, Nusa Tenggara Bar, 83115, Indonesia |
Obese patients have been identified to have a poor prognosis and a higher risk of death from coronavirus disease-2019 (COVID-19). We present reports of two obese patients infected with COVID-19 with acute respiratory distress syndrome (ARDS) who showed improvement with high flow nasal cannula (HFNC). HFNC is a noninvasive oxygen delivery device which is capable of delivering a high concentration of oxygen that can reduce the requirement for tracheal intubation. HFNC is convenient to use, can reduce dyspnea without effecting the length of stay in ICU in these cases; and has a high merit to be used in selected patients requiring oxygen before attempting intubation and mechanical ventilation. © the authors. |
ARDS; COVID-19; HFNC; High flow nasal cannula; Obese |
alanine aminotransferase; antiarrhythmic agent; ascorbic acid; aspartate aminotransferase; azithromycin; C reactive protein; chloroquine; dexamethasone; famotidine; heparin; hypertensive factor; levofloxacin; low molecular weight heparin; methylprednisolone; micafungin; oseltamivir; remdesivir; SARS-CoV-2 convalescent plasma; vancomycin; adult; adult respiratory distress syndrome; ageusia; alanine aminotransferase blood level; anosmia; Article; artificial ventilation; aspartate aminotransferase blood level; case report; clinical article; coronavirus disease 2019; coughing; COVID-19 testing; crackle; diarrhea; drug withdrawal; dyspnea; endotracheal intubation; fever; heart arrhythmia; high flow nasal cannula therapy; hospital admission; human; hypotension; hypoxemia; intensive care unit; le |
Faculty of Anaesthesia, Pain and Intensive Care, AFMS |
16078322 |
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Article |
Q3 |
170 |
21404 |
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431 |
Marzuki N.S., Idris F.P., Kartapradja H., Renata S., Harahap A., Latief Batubara J.R. |
37111053300;57224096699;6504373157;57224098534;6507325543;57224097014; |
Accuracy of urinary etiocholanolone/androsterone ratio as alternative to serum testosterone/dihydrotestosterone ratio for diagnosis of 5 alpha-reductase type 2 deficiency patients and carriers in Indonesia |
2021 |
International Journal of Endocrinology and Metabolism |
19 |
2 |
e109510 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106858176&doi=10.5812%2fIJEM.109510&partnerID=40&md5=262ad88d94d397f7bc55e0ace31050be |
Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Marzuki, N.S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Idris, F.P., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Kartapradja, H., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Renata, S., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Harahap, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Latief Batubara, J.R., Department of Child Health, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The 5 Alpha-reductase type 2 deficiency (5ARD2) is an inherited condition, which clinically presents as variable degrees of under virilization in affected 46,XY individuals. In the diagnostic pathway of 5ARD2, the testosterone/dihydrotestosterone (T/DHT) ratio is broadly employed before molecular analysis of the SRD5A2 gene. However, due to cost-benefit considerations, the DHT test in our country is routinely lacking in clinical settings; therefore, we considered applying the urinary etiocholanolone/androsterone (Et/An) ratio as an alternative test. Objectives: We aimed to determine the diagnostic value of the urinary Et/An ratio versus the T/DHT ratio in diagnosing 5ARD2 patients and carriers. Methods: Sixty-six suspected 5ARD2 46,XY disorders of sex development (DSD) individuals and 95 family members were recruited in the study. Their clinical manifestations, T/DHT and urinary Et/An ratios, and SRD5A2 genes were analyzed. Using molecular analysis of the SRD5A2 gene as the gold standard, we compared the accuracy of both ratios in diagnosing 5ARD2 patients and carriers with receiver operating characteristic (ROC) curve analysis. Results: Thirty-seven patients were confirmed molecularly to have 5ARD2, and the rest (n = 29) were assessed as normal controls, while in the carrier group, 53 were molecularly confirmed as carriers and 42 as controls. The AUCs (areas under the curve) of the T/DHT and urinary Et/An ratios were 57.7% (95% CI 43.0 - 72.4%, P > 0.05) and 79.7% (95% CI 69.0 - 90.4%, P < 0.001), respectively, in diagnosing 5ARD2 patients and 54.1% (95% CI 42.4 - 65.8%, P > 0.05) and 75.1% (95% CI 65.1 - 85.1%, P < 0.001), respectively, in diagnosing carriers. The cutoff value of the urinary Et/An ratio was set at ≥ 0.95 for detecting 5ARD2 patients and ≥ 0.99 for detecting carriers. Conclusions: The testosterone/DHT ratio was inaccurate in diagnosing 5ARD2 patients. When molecular analysis for the SRD5A2 gene is lacking, the urinary Et/An ratio may be a useful test to diagnose 5ARD2 patients and carriers. Copyright © 2021, International Journal of Endocrinology and Metabolism. |
46; 5 Alpha-reductase 2 deficiency; Androsterone; Dihydrotestosterone; Etiocholanolone; SRD5A2; Testosterone; XY DSD |
androstanolone; androsterone; chorionic gonadotropin; etiocholanolone; genomic DNA; steroid; steroid 5alpha reductase 2; testosterone; 5 alpha reductase deficiency; adolescent; adult; analytical parameters; area under the curve; Article; child; clinical article; clinical assessment; clinical feature; competitive ELISA; controlled study; cost benefit analysis; diagnostic accuracy; diagnostic value; disorder of sex development; female; genetic analysis; hormone urine level; human; human tissue; Indonesia; infant; male; molecular biology; neutrophil lymphocyte ratio; newborn; receiver operating characteristic; serum testosterone dihydrotestosterone ratio; testosterone blood level; urinary etiocholanolone androsterone ratio |
Kowsar Medical Institute |
1726913X |
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Article |
Q3 |
652 |
7699 |
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443 |
Shatri H., Putranto R., Faisal E., Fitrianti F., Adhiatma K., Zulmiyusrini P., Diba S.F., Lukman P.R. |
28767986500;56074051000;57218497073;57226626294;57226627483;57208105781;57226627082;55981460300; |
Psychotherapy for Healthcare Provider During COVID-19 Pandemic: An Evidence Based Clinical Review |
2021 |
Acta medica Indonesiana |
53 |
2 |
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225 |
232 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112125259&partnerID=40&md5=67ed7e7351b78d9ad3f635d4564bfa25 |
1. Division of Psychosomatic and Palliative, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia |
Shatri, H., 1. Division of Psychosomatic and Palliative, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital Jakarta, Indonesia. 2. Clinical Epidemiology Unit, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo HospitalJakarta, Indonesia; Putranto, R.; Faisal, E.; Fitrianti, F.; Adhiatma, K.; Zulmiyusrini, P.; Diba, S.F.; Lukman, P.R. |
BACKGROUND: health workers are one of the groups affected physically as well as psychologically from the pandemic. Recent studies showed many of the health workers reported experiencing anxiety, depression, and insomnia. This study aims to identify psychotherapy as a psychological health intervention, for healthcare workers during the COVID-19 pandemic. METHODS: an evidence based clinical review of psychotherapy as a psychological health intervention, reported in the literature, which is developed for healthcare workers during the COVID-19 pandemic. The review was conducted following set out for Evidence-based clinical review by searching the following digital libraries: PubMed, ProQuest, Cochrane, and Google Scholar. RESULTS: six publications were selected. The identified psychotherapy used as a mental or psychological intervention for healthcare workers during COVID-19 consists of supportive psychotherapy, psychoeducation, social support, and music therapy. Overall, it shows that psychotherapy, especially supportive psychotherapy, can reduce anxiety, depression, and insomnia. CONCLUSION: the physiological condition of health workers needs to get attention during the COVID-19 pandemic. Although there is no standard of therapy yet, psychotherapy could be an option as it is proven to be able to reduce anxiety, depression, and insomnia. |
COVID-19; healthcare workers; internal medicine; medical journal; psychosomatic; psychotherapy |
epidemiology; evidence based medicine; health care personnel; human; pandemic; psychology; psychotherapy; COVID-19; Evidence-Based Medicine; Health Personnel; Humans; Pandemics; Psychotherapy; SARS-CoV-2 |
NLM (Medline) |
01259326 |
|
34251353 |
Review |
Q3 |
321 |
14162 |
|
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444 |
Wardoyo E.Y., Nainggolan G., Hustrini N.M., Setiati S. |
57219411333;23498775400;57200424892;14325991900; |
Factors Associated with Arterial Stiffness in Chronic Hemodialysis Patients in Jakarta: The Role of Hemodialysis Frequency and Pentraxin 3 |
2021 |
Acta medica Indonesiana |
53 |
2 |
|
177 |
183 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111583410&partnerID=40&md5=48c271443cfc8fc3a9b8370bf863e403 |
Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia |
Wardoyo, E.Y., Department of Internal Medicine, Faculty of Medicine Universitas IndonesiaJakarta, Indonesia; Nainggolan, G.; Hustrini, N.M.; Setiati, S. |
BACKGROUND: arterial stiffness is a mortality predictor in hemodialysis patients, hemodialysis induces inflammation, marked by an intradialysis increase in the inflammatory marker pentraxin 3 (PTX3). Arterial stiffness in twice-weekly hemodialysis patients in Indonesia is lower than has been found in studies of thrice-weekly patients. This study therefore aims to determine the factors associated with arterial stiffness, focusing on the role of hemodialysis frequency and PTX3. METHODS: a cross-sectional study was conducted at Cipto Mangunkusumo Hospital, Fatmawati Hospital, and Medistra Hospital involving patients with twice- and thrice-weekly hemodialysis. Arterial stiffness was measured by carotid-femoral pulse wave velocity after hemodialysis, and blood samples for PTX3 testing were taken before hemodialysis. Bivariate and multivariate analyses were performed using chi-squared tests and logistic regression. RESULTS: out of 122 subjects, 82 underwent twice-weekly hemodialysis. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. In bivariate analysis, PTX3, cardiovascular disease, dialysis vintage had p values of <0.05, while the subsequent multivariate analysis showed that PTX3>2.3 ng/ml was associated with arterial stiffness (adjusted OR 5.18; 95% CI 1.07-24.91), as well as cardiovascular disease (adjusted OR 3.67; 95% CI 1.40-10.55), LDL (adjusted OR 3.10; 95% CI 1.04-9.24), and dialysis vintage (adjusted OR 2.72; 95% CI 1.001-7.38). CONCLUSION: predialysis PTX3 levels above 2.3 ng/ml were associated with arterial stiffness. There was no difference in arterial stiffness between patients with twice- and thrice-weekly hemodialysis. |
arterial stiffness; hemodialysis frequency; pentraxin 3; pulse wave velocity |
biological marker; C reactive protein; pentraxin 3; serum amyloid P; adult; aged; arterial stiffness; blood; blood flow velocity; chronic kidney failure; clinical trial; cross-sectional study; female; hemodialysis; human; Indonesia; male; metabolism; middle aged; multicenter study; multivariate analysis; physiology; pulse wave; statistical model; Adult; Aged; Biomarkers; Blood Flow Velocity; C-Reactive Protein; Cross-Sectional Studies; Female; Humans; Indonesia; Kidney Failure, Chronic; Logistic Models; Male; Middle Aged; Multivariate Analysis; Pulse Wave Analysis; Renal Dialysis; Serum Amyloid P-Component; Vascular Stiffness |
NLM (Medline) |
01259326 |
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34251346 |
Article |
Q3 |
321 |
14162 |
|
|
445 |
Pramono L.A., Yunir E., Tarigan T.J.E., Nusanti S., Aman R.A., Suroyo I. |
37063602400;36520254800;36057746500;57189727162;57226434769;57204106272; |
Giant Recurrence Pituitary Adenoma After Three Times Transphenoidal Removal Surgery, One Craniotomy Procedure, and 30 Doses of External Radiotherapy |
2021 |
Acta medica Indonesiana |
53 |
2 |
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221 |
224 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111572434&partnerID=40&md5=3fbf4691ce27b57e71d3a91134445173 |
1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia |
Pramono, L.A., 1. Department of Internal Medicine, Faculty of Medicine Universitas Indonesia - Cipto Mangunkusumo Hospital, Indonesia. 2. Department of Public Health and Nutrition, School of Medicine and Health Sciences Universitas Katolik Indonesia Atma Jaya - Department of Internal Medicine St Carolus HospitalJakarta, Indonesia; Yunir, E.; Tarigan, T.J.E.; Nusanti, S.; Aman, R.A.; Suroyo, I. |
This is a case of 42nd year-old woman with history of sight loss in her both eyes. She experienced headache and visual field decrease gradually since 2014. After several laboratory and imaging examinations, from her dynamic pituitary magnetic resonance imaging (MRI), it is concluded that she had a giant adenoma of the pituitary gland which compressed to her optic chiasm. From her pituitary laboratory hormone panel, it is revealed that the tumor is a non-functioning pituitary adenoma. From the neuro-ophthalmology (campimetry) examinations, she had papillae atrophy in her both eyes and also bilateral temporal hemianopia. |
Giant Recurrence Pituitary Adenoma; Radiotherapy; Transphenoidal Removal Surgery |
adenoma; adult; case report; craniotomy; female; hemianopia; human; hypophysis tumor; nuclear magnetic resonance imaging; optic nerve; pathology; tumor recurrence; Adenoma; Adult; Craniotomy; Female; Hemianopsia; Humans; Magnetic Resonance Imaging; Neoplasm Recurrence, Local; Optic Nerve; Pituitary Neoplasms |
NLM (Medline) |
01259326 |
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34251352 |
Article |
Q3 |
321 |
14162 |
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