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651 |
Sudarma V., Hegar B., Hidayat A., Agustina R. |
55257657600;6506273944;7006069132;57214141404; |
Human Milk Oligosaccharides as a Missing Piece in Combating Nutritional Issues during Exclusive Breastfeeding |
2021 |
Pediatric Gastroenterology, Hepatology and Nutrition |
24 |
6 |
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501 |
509 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121005273&doi=10.5223%2fpghn.2021.24.6.501&partnerID=40&md5=55bd98613f1bc0613d5d9ff96f327b95 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Department of Child Health, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Public Health, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Human Nutrition Research Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Sudarma, V., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Department of Nutrition, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Hegar, B., Department of Child Health, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Hidayat, A., Department of Public Health, Faculty of Medicine, Trisakti University, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center, Indonesia Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Extensive studies have shown that breast milk is the best source of nutrition for infants, especially during the first six months, because it fulfills almost all of their nutritional needs. Among the many functional building blocks in breast milk, human milk oligosaccharides (HMOs) have been receiving more attention recently. Furthermore, it is the third most common group of compounds in human milk, and studies have demonstrated the health benefits it provides for infants, including improved nutritional status. HMOs were previously known as the ‘bifidus factor' due to their ‘bifidogenic' or prebiotic effects, which enabled the nourishment of the gastrointestinal microbiota. Healthy gastrointestinal microbiota are intestinal health substrates that increase nutrient absorption and reduce the incidence of diarrhea. In addition, HMOs, directly and indirectly, protect infants against infections and strengthen their immune system, leading to a positive energy balance and promoting normal growth. Non-modifiable factors, such as genetics, and modifiable factors (e.g., maternal health, diet, nutritional status, environment) can influence the HMO profile. This review provides an overview of the current understanding of how HMOs can contribute to the prevention and treatment of nutritional issues during exclusive breastfeeding. © 2021. The Korean Society of Pediatric Gastroenterology, Hepatology and Nutrition. All Rights Reserved. |
Breast feeding; Human milk; Nutritional status; Oligosaccharides |
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Korean Society of Pediartic Gastroenterology, Hepatology and Nutrition |
22348646 |
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Article |
Q3 |
440 |
11229 |
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657 |
Irawan C., Benbella L.G., Rachman A., Mansjoer A. |
28767651600;57357413600;15056701600;24335647800; |
Factors that Influence 2-Year Progression-Free Survival Among Head and Neck Cancer Patients |
2021 |
Journal of Epidemiology and Global Health |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120335157&doi=10.1007%2fs44197-021-00016-2&partnerID=40&md5=eae0237d32c525daedf560529a50ad64 |
Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jl. Diponegoro no. 71, Jakarta, 10430, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia; Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia |
Irawan, C., Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jl. Diponegoro no. 71, Jakarta, 10430, Indonesia; Benbella, L.G., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia; Rachman, A., Hematology and Medical Oncology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jl. Diponegoro no. 71, Jakarta, 10430, Indonesia; Mansjoer, A., Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia-Cipto Mangunkusumo National Central General Hospital (RSCM), Jakarta, Indonesia |
Objectives: The majority of patients with head and neck cancer (HNC) come to the hospital at advanced stages. This research was conducted to determine the mortality, 2-year progression-free survival (PFS) and factors that influenced PFS of HNC patients. Methods: A retrospective cohort study was conducted among locally advanced HNC patients who underwent chemoradiation for the first time at RSCM from January 2015 to December 2017. Data were retrieved through medical records. Laboratory data were taken 2–4 weeks prior and 2–4 weeks after chemoradiation. PFS observation started from the first day of chemoradiation until disease progression or death. PFS data were recorded in two groups: ≤ 2 years and > 2 years. The Chi-square test was used for bivariate analysis with the Fischer-exact test as an alternative. Variables will be further tested using multivariate logistic regression tests. Results: Among 216 subjects, there were 103 (47.69%) patients who did not reach overall survival (OS) > 2 years. There were 108 (50%) patients who had PFS > 2 years. Based on the results of multivariate analysis, it was found that smoking, hemoglobin level ≤ 12 g/dl, ECOG (Eastern Cooperative Oncology Group) 1–2, and negative therapeutic response were associated with poor PFS. Hazard ratio (HR) for 2-year PFS for Brinkman index > 250 was 1.36 (95% CI 0.93–2.00; p = 0.02); HR for Hb ≤ 12 g/dl was 1.65 (95% CI 1.13–2.42; p = 0.01); HR for ECOG 1–2 was 4.05 (95% CI 1.49–11.00; p < 0.01); and HR for negative therapeutic response was 2.37 (95% CI 1.43–3.94; p < 0.01). Conclusion: Mortality of HNC patients within 2 years is 47.69%, with a 2-year PFS reaching 50%. Cigarette smoking, low hemoglobin levels, poor performance status, and negative therapeutic response (non-responders) negatively affect the 2-year PFS. © 2021, The Author(s). |
Factor; Head and neck cancer; Mortality; Progression-free survival |
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Atlantis Press |
22106006 |
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Article |
Q3 |
665 |
7531 |
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659 |
Dewi S., Yulhasri Y., Mulyawan W. |
57192904541;57225180520;57192910410; |
The Impact of Intermittent Hypobaric Hypoxia Exposures on Triacylglycerol Synthesis in Rat Liver |
2021 |
Reports of Biochemistry and Molecular Biology |
10 |
3 |
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437 |
444 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120058392&partnerID=40&md5=0ff2179c774f4a9d0d0a1c462ec80dc4 |
Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia |
Dewi, S., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mulyawan, W., Department of Aerophysiology, Lakespra Saryanto, Air Force Indonesian National Army, Jakarta, Indonesia |
Background: In a hypoxic state, fatty acid breakdown reaction may be inhibited due to a lack of oxygen. It is likely that the fatty acids will be stored as triacylglycerol. The aim of this study was to analyse triacylglycerol synthesis in the liver after intermittent hypobaric hypoxia (HH) exposures. Methods: Samples are liver tissues from 25 male Wistar rats were divided into 5 groups: controlgroup (normoxia), group I (once HH exposure), group II (twice HH exposures), group III (three-times HH exposures) and group IV (four-times HH exposures). The triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ were measured in rat liver from each group.Results: We demonstrated that triacylglycerol level, mRNA expression of HIF-1α and PPAR-γ is elevated in group I significantly compared to control group. In the intermittent HH groups (group II, III and IV), mRNA expression of HIF-1α and PPAR-γ tends to downregulate near to control group. However, the triacylglycerol level is still found increased in the intermittent HH exposures groups. Significant increasing of triacylglycerol level was found especially in group IV compared to control group.Conclusions: We conclude that intermittent HH exposures will increase the triacylglycerol level in rat liver, supported by the increasing of HIF-1α and PPAR-γ mRNA expression that act as transcription factor to promote triacylglycerol synthesis © 2021. Reports of Biochemistry & Molecular Biology. All Rights Reserved. |
HIF-1α; Hypoxia; Liver; PPAR-γ; Triacylglycerol |
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Varastegan Institute for Medical Sciences |
23223480 |
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Article |
Q3 |
467 |
10677 |
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661 |
Andreas A.M., Djuwita R., Helda H., Sekartni R., Suradijono S.H.R., Wiguna T., Tulaar A.B.M., Kristianto Y., Hendrik H. |
57356220700;56586138300;57195467249;57355240300;57209473358;57356086800;24330360800;57356220800;57355801600; |
Massage therapy can prevent the risk of autism spectrum disorders in children |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
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1556 |
1560 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120032396&doi=10.3889%2foamjms.2021.7436&partnerID=40&md5=ca9744bb24e561c7ddfc3916dd11ecc2 |
Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Department of Pediatrics and Development, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Developmental Psychology, Faculty of Psychology, University of Indonesia, Jakarta, Indonesia; Department of Child Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Medical Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Health Polytechnic, Ministry of Health Jakarta 1, Jakarta, Indonesia; Department of Physiotherapy, Health Polytechnic, Ministry of Health Makassar, Makassar, Indonesia |
Andreas, A.M., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Djuwita, R., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Helda, H., Faculty of Public Health, University of Indonesia, Jakarta, Indonesia; Sekartni, R., Department of Pediatrics and Development, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Suradijono, S.H.R., Department of Developmental Psychology, Faculty of Psychology, University of Indonesia, Jakarta, Indonesia; Wiguna, T., Department of Child Psychiatry, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Tulaar, A.B.M., Department of Medical Rehabilitation, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Kristianto, Y., Health Polytechnic, Ministry of Health Jakarta 1, Jakarta, Indonesia; Hendrik, H., Department of Physiotherapy, Health Polytechnic, Ministry of Health Makassar, Makassar, Indonesia |
BACKGROUND: The prevalence of human beings with autism spectrum issues in some parts of the world tends to make bigger, in Indonesia alone, accurate and complete data and information from human beings with autism spectrum disorders (ASD) are nonetheless missing, so it is feared that many children with risk symptoms of ASD do not get treatment early. AIM: This research aims to prevent the risk of ASD in children through making use of massage therapy remedies based on evaluation of the Modified Checklist for Autism in Toddler (modified Chat [M-Chat]) ratings. METHODS: This research is a quasi-experimental study with a time series design which was carried out from May 2019 to March 2020 at three health centers in the city of Jakarta. The analysis was carried out before and after the application of massage in a time series of four periods on ten children aged 18–36 months with M-Chat scores, and then analyzed by receiver operating characteristics to obtain a cutoff point to determine the risk status of ASD. RESULTS: The results showed that there was an effect of massage therapy on the M-Chat score of children with ASD risk p = 0.004 < 0.05 and changes in the M-Chat score of children with ASD risk experienced significant changes after massage in the third and fourth therapy periods with p = 0.005 and p = 0.007 < 0.05. CONCLUSION: The results show that massage therapy can prevent of autism spectrum issues in children based on the Modified Checklist for Autism in Toddler (M-Chat). © 2021 Andy Martahan Andreas, Ratna Djuwita, Helda Helda, Rini Sekartni, Sri Hartati R. Suradijono, Thjin Wiguna, Angela B. M. Tulaar, Yusuf Kristianto, Hendrik Hendrik. |
Autism spectrum disorders; Babies; Massage therapy; Modified checklist for autism in toddler |
Article; autism; cesarean section; checklist; child; chromosome aberration; female; health center; human; human experiment; Indonesia; male; massage; pH; predictive value; preschool child; prevalence; prospective study; QT interval; quasi experimental study; receiver operating characteristic; scoring system; sensitivity and specificity; time series analysis; toddler |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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666 |
Sukrisman L., Sinto R. |
8661764000;36099377100; |
Coagulation profile and correlation between D-dimer, inflammatory markers, and COVID-19 severity in an Indonesian national referral hospital |
2021 |
Journal of International Medical Research |
49 |
11 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119613636&doi=10.1177%2f03000605211059939&partnerID=40&md5=c946e5b0ffec2b5ef4b8bd521da19dbf |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Sukrisman, L., Division of Hematology and Medical Oncology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo National Hospital, Jakarta, Indonesia; Sinto, R., Division of Tropical and Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, University of Indonesia - Cipto Mangunkusumo National Hospital, Jakarta, Indonesia |
Background: Coagulopathy and inflammation are associated with coronavirus disease 2019 (COVID-19) severity. This study assessed D-dimer concentration and its correlation with inflammatory markers and COVID-19 severity. Methods: This was a retrospective cross-sectional study involving 194 COVID-19 cases, with the severity of infection graded in accordance with the World Health Organization (WHO) guidelines. We measured D-dimer, C-reactive protein (CRP), and ferritin on admission and determined the cutoff values for D-dimer and CRP and evaluated the correlation between D-dimer and CRP and ferritin. Results: Median D-dimer, CRP, and ferritin concentrations were 2240 µg/L, 73.2 mg/L, and 1173.8 µg/mL, respectively. The highest median D-dimer value was seen in mild and moderate acute respiratory distress syndrome (ARDS). The highest ferritin concentration was seen in severe ARDS. There was a significant correlation between D-dimer value and CRP (r = 0.327), but no significant correlation between D-dimer and ferritin (r = 0.101). The area under the receiver operating characteristic curve (AUC) for the combination of CRP ≥72.65 mg/L and D-dimer ≥1250 µg/L as a marker of COVID-19 severity was 0.722 (95% confidence interval (CI): 0.615–0.781). Conclusion: The combination of CRP ≥72.65 mg/L and D-dimer ≥1250 µg/L can be used as marker of COVID-19 severity, with moderate accuracy. © The Author(s) 2021. |
acute respiratory distress syndrome; C-reactive protein; Coronavirus disease 2019; correlation; D-dimer; ferritin; inflammation; severity |
biological marker; fibrin degradation product; fibrin fragment D; cross-sectional study; hospital; human; Indonesia; patient referral; retrospective study; severity of illness index; Biomarkers; COVID-19; Cross-Sectional Studies; Fibrin Fibrinogen Degradation Products; Hospitals; Humans; Indonesia; Referral and Consultation; Retrospective Studies; SARS-CoV-2; Severity of Illness Index |
SAGE Publications Ltd |
03000605 |
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34796762 |
Article |
Q3 |
421 |
11626 |
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670 |
Mustika R., Yo E.C., Faruqi M., Zhuhra R.T. |
57220273147;57213188908;57339401900;57220591134; |
Evaluating the relationship between online learning environment and medical students’ wellbeing during covid-19 pandemic |
2021 |
Malaysian Journal of Medical Sciences |
28 |
5 |
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108 |
117 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119154731&doi=10.21315%2fmjms2021.28.5.11&partnerID=40&md5=d5595e080d252a1b132526ffc8da06b5 |
Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Mustika, R., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Medical Education Collaboration Cluster, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia, Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yo, E.C., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Faruqi, M., Medical Education Center, Indonesian Medical Education and Research Institute (IMERI), Universitas Indonesia, Jakarta, Indonesia; Zhuhra, R.T., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background: The coronavirus disease 2019 (COVID-19) pandemic has been found to negatively affect medical students’ wellbeing. This finding may be related to how medical education is being conducted at present, with online learning replacing face-to-face teaching in many countries. This cross-sectional study aims to assess how the online learning environment is connected to medical students’ wellbeing. Methods: A self-administered online questionnaire was distributed to undergraduate medical students at Universitas Indonesia. The study was conducted from September 2020 to February 2021. The questionnaire included a modified version of the Online Learning Environment Scale (OLES) and the Positive Emotion, Engagement, Relationships, Meaning and Accomplishment (PERMA) profiler. The OLES was used to evaluate students’ perceptions of the online learning environment, whereas the PERMA Profiler was used to evaluate students’ wellbeing. We validated the questionnaire before distribution. The content validity index was 1.0, with internal consistency coefficients of 0.87 and 0.89, respectively. Regression analyses were performed to evaluate the relationship between OLES and PERMA scores. Results: The questionnaire was completed by 274 undergraduate medical students. Students reported moderate to high degrees of positive perception towards online learning, high levels of positive emotions and moderate levels of negative emotions. Statistically significant differences were found across groups based on students’ gender, year of study and academic programme. Almost all aspects of the online learning environment were significantly predictive of students’ wellbeing, with personal relevance and evaluation and assessment being the two most important predictors (R2 = 0.201; P < 0.001). Conclusion: Medical students generally enjoyed online learning, although some challenges were presented. The online learning environment was positively associated with students’ wellbeing; however, some students expressed negative emotions including loneliness, anxiety, anger and sadness. © 2021, Penerbit Universiti Sains Malaysia. All rights reserved. |
COVID-19; Medical students; Online learning environment; Wellbeing |
adult; anger; anxiety; Article; behavioral synchrony; coronavirus disease 2019; cross-sectional study; demography; e-learning; emotion; female; health equity; human; human experiment; learning; learning environment; loneliness; male; medical education; medical student; normal human; pandemic; patient engagement; psychological well-being; questionnaire; sadness; social interaction; undergraduate student; validation study; wellbeing |
Penerbit Universiti Sains Malaysia |
1394195X |
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Article |
Q3 |
394 |
12287 |
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680 |
Sandora N., Putra M.A., Nurhayati R.W., Suwarti, Nauli R., Kusuma T.R., Fitria N.A., Ardiansyah, Muttaqin C., Makdinata W., Alwi I. |
57204103434;57215605850;55748436600;57212462722;57212478305;57222897694;57148498800;57223036386;57226442135;57223405655;15055173800; |
Characterisation of the single-cell human cardiomyocytes taken from the excess heart tissue of the right ventricular outlet in congenital heart disease |
2021 |
Cell and Tissue Banking |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118214107&doi=10.1007%2fs10561-021-09970-4&partnerID=40&md5=2c4fad90958206777aa1ef5e9ea1e5ec |
Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia; Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Sandora, N., Faculty of Medicine, Universitas Riau, Pekanbaru, 28293, Indonesia, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Putra, M.A., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Nurhayati, R.W., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Suwarti, Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Nauli, R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Kusuma, T.R., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Fitria, N.A., Indonesia Medical Education and Research Institute, Jakarta, 10430, Indonesia; Ardiansyah, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Muttaqin, C., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Makdinata, W., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia; Alwi, I., Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Cardiovascular disease is the second highest cause of death across the globe. Myocardial infarction is one of the heart diseases that cause permanent impairment of the heart wall leads to heart failure. Cellular therapy might give hope to regenerate the damaged myocardium. Single cells isolated from an excess heart tissue obtained from the correction of the right ventricular hypertrophy in patients with Tetralogy of Fallot for future heart study were investigated. Methods: Once resected, the heart tissues were transported at 37 °C, in Dulbecco's Modified Eagle's medium/ DMEM (4.5 g.L−1, antibiotic–antimycotic 3x, PRP10% (v/v)), to reach the lab within 30 min, weighted and grouped into less than 500 mg and more than 1000 mg (n = 4). Each sample was digested with 250 U.mL−1 Collagenase type V and 4U.mL−1 Proteinase XXIV in the MACS™ C-tube (Milltenyi, Germany), then dissociated using the MACS™ Octo Dissociator with Heater (Milltenyi, Germany) for 60 min at 37 °C. Results: All cells isolated were rod-shaped cells; viability was up to 90%. The cell density obtained from the 500 mg group were 4,867 ± 899 cells.mg−1 tissue weight, significantly higher compared to the 1,000 mg group; had 557 ± 490 cells.mg−1 tissue weight (mean of (n = 3) ± 95% C.l). The isolated cells were analyzed using FACs BD Flowcytometer, expressed cTnT + 13.38%, PECAM-1 + /VCAM-1- 32.25%, cKit + 7.85%, ICAM + 85.53%, indicating the cardiomyocyte progenitor cells. Conclusion: Cardiomyocytes taken from the wasted heart tissue might be a candidate of cardiomyocytes source to study interventions to the heart as it contained up to 13.38% cardiomyocytes, and 32.25% of cardiac progenitor cells. Moreover, perhaps when cardiac cell therapy needs autologous cardiomyocytes, less than 500 mg tissue weight can be considered as sufficient. © 2021, The Author(s), under exclusive licence to Springer Nature B.V. |
Cardiac progenitor cells; Cardiomyocyte isolation; Right ventricular resection; Tetralogy of fallot; Waste heart tissue |
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Springer Science and Business Media B.V. |
13899333 |
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Article |
Q3 |
397 |
12196 |
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681 |
Purbadi S., Tjahjadi H., Purwoto G., Kusuma F., Winarto H., Utami T.W., Indarti J., Sotarduga G.E. |
6505677307;57210953454;14720170400;57192911548;54080645300;57195720528;39161587400;57226332860; |
Early gestational age placenta accreta case report: Can we avoid missed diagnosis? |
2021 |
American Journal of Case Reports |
22 |
1 |
e934168 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118201241&doi=10.12659%2fAJCR.934168&partnerID=40&md5=ad11e65742808074c47abe298cdbe9f7 |
Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Pathology and Anatomy, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Obstetrics and Gynecology, University of Indonesia Dr. Cipto Mangunkusumo National Referral Hospital Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Purbadi, S., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Tjahjadi, H., Department of Pathology and Anatomy, Faculty of Medicine, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Purwoto, G., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Kusuma, F., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Winarto, H., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Utami, T.W., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Indarti, J., Department of Obstetrics and Gynecology, University of Indonesia Dr. Cipto Mangunkusumo National Referral Hospital Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Sotarduga, G.E., Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Objective: Background: Case Reports: Conclusions: Mistake in diagnosis Placenta accreta is an abnormal invasive placenta that can be life-threatening because of the risk of hemorrhage. Its incidence has increased due to high cesarean delivery rates. Early gestational age placenta accreta is difficult to diagnose and misdiagnosis can lead to inappropriate treatment. Patient 1, a 34-year-old woman (para 2 abortus 1) with 2 previous cesarean deliveries, was referred to our department for vaginal bleeding and abdominal pain. She received 2 curettages for blighted ovum; then, ultrasound examination found uterus perforation and fluid in the Douglas cavity. Exploratory laparotomy confirmed uterine perforation, and a hysterectomy was performed. Histopathological examination revealed placenta accreta. Patient 2, a 35-year-old woman (para 3) with 3 previous cesarean deliveries, was treated at a previous hospital for vaginal bleeding and stomach enlargement. She received serial chemotherapy for gestational trophoblastic neoplasia. Ultrasound examination showed a nonhomogeneous opacity in the lower uterine corpus with color score 4. Total abdominal hysterectomy was performed, and histopathological examination revealed placenta accreta. Patient 3, a 32-year-old woman (para 2) with 2 previous cesarean deliveries, had irregular vaginal bleeding suspected as gestational trophoblastic neoplasia due to ultrasound examination and positive beta-human chorionic gonadotropin. Ultrasound and MRI examination showed enlargement with nonhomogeneous opacity, color score 4, and bridging vessels. Due to our previous experience, we suspected it was a placenta accreta and performed a hysterectomy. The histopathology result indicated placenta accreta. The key point in diagnosing placenta accreta properly is to evaluate the morphometric changes based on the structure using imaging like ultrasound. Collection and analysis of these data enables precise diagnosis in early gestational age placenta accreta. © 2021, International Scientific Information, Inc.. All rights reserved. |
Cesarean section; Diagnostic techniques, obstetrical and gynecological; Placenta accreta |
analgesic agent; antibiotic agent; methotrexate; abdominal hysterectomy; abdominal pain; abdominal swelling; adult; Article; blighted ovum; cancer chemotherapy; case report; cesarean section; choriocarcinoma; clinical article; diagnostic error; dilatation and curettage; Doppler flowmetry; echography; emergency ward; female; fever; follow up; gestational age; histopathology; hospital admission; hospital discharge; human; hypovolemic shock; hysterectomy; laparotomy; missed abortion; nuclear magnetic resonance imaging; patient referral; pelvic inflammatory disease; placenta accreta; rectouterine pouch; spontaneous abortion; spotting; treatment duration; trophoblastic tumor; uterus disease; uterus perforation; vagina bleeding; diagnostic imaging; gestational age; placenta; placenta accreta; pr |
International Scientific Information, Inc. |
19415923 |
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34719664 |
Article |
Q3 |
247 |
16822 |
|
|
691 |
Wulandari P., Kusdhany L.S., Masulili S.L.C., Puspitadewi S.R., Baziad A. |
57201898722;55301180900;55855884100;57203025561;6506424401; |
The Relationship between Tooth Loss and Gingival Status with Oral Hygiene in Postmenopausal Women |
2021 |
Journal of International Dental and Medical Research |
14 |
3 |
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1057 |
1063 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116900014&partnerID=40&md5=2c741b2f8115ddf2d39627ed1a432c91 |
Department of Periodontics, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas Prof. Dr.Moestopo, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wulandari, P., Department of Periodontics, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia; Kusdhany, L.S., Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Masulili, S.L.C., Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Puspitadewi, S.R., Department of Prosthodontics, Faculty of Dentistry, Universitas Prof. Dr.Moestopo, Jakarta, Indonesia; Baziad, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Poor oral hygiene can lead to further periodontal damage, especially in the postmenopausal pre-elderly who are deficient in estrogen. This study aimed to analyze the relationship between socio-demographic factors, tooth loss and gingival status on oral hygiene in postmenopausal women aged 45 until 59 years old. This study was a cross-sectional study of postmenopausal women aged 45 until 59 years old with periodontitis in Jakarta Indonesia Information about age, education level and duration of menopause were obtained through interviews and history taking. Clinical examination was performed to check the oral hygiene index, the number of tooth loss and gingival status, namely the plaque index, papillary bleeding index. The results of this study showed that subjects who lost their teeth ≥4 (57.10%) had poor oral hygiene compared to <4 (42.90%) however, the Spearman correlation test showed that there was no significant relationship between the number of tooth losses (p = 0.907) with oral hygiene index. Pearson correlation test showed that there was a significant relationship between gingival status as measured by plaque index and papillary bleeding index (p=0.001) with the oral hygiene index. The conclusion of this study, postmenopausal women are prone to experience problems in the oral cavity, especially periodontal tissue. Socio-demographic factors such as age, level of education and also the length of menopause were not significantly associated with oral hygiene; however, there was a significant relationship between gingival status and oral hygiene in postmenopausal women aged 45 until 59 years old © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Estrogen; Oral hygiene index; Periodontal; Postmenopausal; Tooth loss |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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693 |
Hardiany N.S., Kirana A.N., Prafiantini E. |
57192910605;57222361321;57193088368; |
Oxidative Stress in the Elderly with Hypertension: A Cross-Sectional Study |
2021 |
Journal of International Dental and Medical Research |
14 |
3 |
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1246 |
1250 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116866069&partnerID=40&md5=3e8984a3a06a6eef33f0305c742b648f |
Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Hardiany, N.S., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kirana, A.N., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Hypertension is a major health problem, especially in the elderly, because it serves as a risk I factor for cardio- and cerebrovascular diseases. The involvement of oxidative stress in hypertension I has been shown in animal studies. However, the data about oxidative stress in humans with I hypertension, especially in the elderly, are still limited. The aim of this study is to analyze oxidative stress by measuring carbonyl and superoxide I dismutase (SOD) in hypertensive elderly. It was a cross-sectional study conducted on 70 elderly I subjects, 35 subjects with hypertension and 35 subjects with normotension, in Jakarta, Indonesia. I Subjects were classified into the hypertensive group if their systolic blood pressure was > 130 I mmHg or their diastolic blood pressure was > 80 mmHg according to American guidelines. Plasma I carbonyl and SOD were measured using a spectrophotometer. Correlation analysis and I Independent T-test were used for statistical analysis. Carbonyl was significantly higher, while SOD I was significantly lower in hypertensive elderly compared to the control. There was a negative I correlation between SOD and systolic blood pressure, as well as a weak positive correlation I between carbonyl and mean arterial pressure. In conclusion, a significant increase of carbonyl and decrease of SOD were detected in I hypertensive elderly, reflecting oxidative stress. © 2021. All Rights Reserved. |
Carbonyl; elderly; hypertension; superoxide dismutase |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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