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695 |
Adiarto S., Kurnianingsih N., Prasetya I., Nugroho F.W., Uberoi R. |
8603606800;57223044495;56725585200;57290221600;22136581000; |
Successful Primary PCI in Stanford Type A Aortic Dissection Complicated by Inferior ST-Elevation Myocardial Infarction: A Case in a Facility with No Surgical Backup |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116762000&doi=10.1055%2fs-0041-1735205&partnerID=40&md5=3716852a47a6df47d93b73adfb8623d6 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Harapan Kita National Cardiovascular Center, Jl. Letjen S. Parman Kav. 87 Slipi, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Department of Radiology, John Radcliffe Hospital, Headington, Oxford, United Kingdom |
Adiarto, S., Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, Harapan Kita National Cardiovascular Center, Jl. Letjen S. Parman Kav. 87 Slipi, Jakarta, 11420, Indonesia; Kurnianingsih, N., Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Prasetya, I., Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Nugroho, F.W., Department of Cardiology and Vascular Medicine, Faculty of Medicine Brawijaya University, Dr. Saiful Anwar Hospital, East Java, Malang, Indonesia; Uberoi, R., Department of Radiology, John Radcliffe Hospital, Headington, Oxford, United Kingdom |
Mortality of type A aortic dissection (TAAD) complicated with coronary malperfusion syndrome is very high even when emergency surgery is performed. Several reports suggested that primary percutaneous coronary intervention (PPCI) followed by immediate corrective surgery may reduce mortality. In many countries, immediate transfer to an aortic surgery center may not be possible. We report a case of TAAD complicated by coronary malperfusion successfully treated with PPCI followed by elective corrective surgery. A 48-year-old man was referred to emergency department with acute inferior ST-elevation myocardial infarction (STEMI) and underwent PPCI. During the procedure, we realized that the cause of STEMI was TAAD. We decided to continue because the patient experienced seizures and bradycardia. Subsequently, echocardiography and computed tomography confirmed the dissection. The patient was discharged and referred to the National Cardiovascular Center where he underwent successful elective surgery. In this patient, immediate revascularization was lifesaving and served as a bridging procedure before surgical correction. © 2021 Georg Thieme Verlag. All rights reserved. |
aortic dissection; coronary intervention; coronary malperfusion syndrome; malperfusion syndrome; primary PCI; STEMI; type A aortic dissection |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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696 |
Nugraha R.A., Muliawan H.S., Nugroho N.T., Ikhsan M., Adiarto S. |
57220785065;57203644653;57211452795;57291104400;8603606800; |
Catastrophic Concomitant Arterial and Venous Thrombosis in a Mild COVID-19-Positive Patient |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116737806&doi=10.1055%2fs-0041-1735200&partnerID=40&md5=35939b91c7ecfee83d98ad94c4b7e884 |
Department of General Medicine, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Prof Bahder Djohan, Pondok Cina, Beji, Depok, 16424, Indonesia; Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia Hospital, Depok, Indonesia; Department of Vascular and Endovascular Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia; Department of Internal Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia |
Nugraha, R.A., Department of General Medicine, Universitas Indonesia Hospital, Universitas Indonesia, Jl. Prof Bahder Djohan, Pondok Cina, Beji, Depok, 16424, Indonesia; Muliawan, H.S., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia Hospital, Depok, Indonesia; Nugroho, N.T., Department of Vascular and Endovascular Surgery, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia; Ikhsan, M., Department of Internal Medicine, Cipto Mangunkusumo Hospital, Universitas Indonesia Hospital, Depok, Indonesia; Adiarto, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Center Harapan Kita, Universitas Indonesia Hospital, Depok, Indonesia |
Since its first discovery in late 2019, coronavirus disease 2019 (COVID-19) has been a global burden associated with significant morbidity and mortality. COVID-19 has been correlated with the development of hypercoagulable state that predisposes the patients to a higher risk of thromboembolism. Current evidence suggests higher incidence of thrombosis, particularly venous thrombosis, among hospitalized COVID-19 patients, mostly with critical illness. On the other hand, there is currently no data regarding the incidence of vivid thrombosis in ambulatory patients with mild COVID-19 and the incidence of concomitant arterial and venous thrombosis in COVID-19 is extremely rare. Herein, we describe catastrophic outcomes of concomitant lower limb arterial and venous thrombosis in a patient with mild COVID-19. This report highlights the occurrence of concomitant arterial and venous thrombosis in ambulatory setting and that this phenomenon resulted in catastrophic clinical consequences. © 2021 Georg Thieme Verlag. All rights reserved. |
acute limb ischemia; ambulatory; anticoagulation; deep vein thrombosis; ischemia-reperfusion injury; mild COVID-19; thrombectomy |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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704 |
Setiani R.U., Batubara E.A.D., Adiarto S., Siddiq T., Indriani S., Siahaan I.H. |
57277340700;57220786003;8603606800;57206239827;57213831064;57278163100; |
Successful Ovarian Vein Embolization of a Multiparous Woman with Pelvic Congestion Syndrome |
2021 |
International Journal of Angiology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115934784&doi=10.1055%2fs-0041-1731272&partnerID=40&md5=3d3e2b558ea0c0ec2f0afad82a5a9503 |
Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Department of Cardiology and Vascular Medicine, Persahabatan Public Hospital, Jakarta, Indonesia |
Setiani, R.U., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Batubara, E.A.D., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Adiarto, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Siddiq, T., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Indriani, S., Department of Cardiology and Vascular Medicine, National Cardiovascular Centre Harapan Kita, Faculty of Medicine, Universitas Indonesia, Jakarta, 11420, Indonesia; Siahaan, I.H., Department of Cardiology and Vascular Medicine, Persahabatan Public Hospital, Jakarta, Indonesia |
Pelvic congestion syndrome (PCS) is a clinical syndrome supported by specific findings, such as ovarian vein's dilatation, that cause pelvic vein congestion. Although many theories are explaining the pathophysiologies of this condition, the underlying cause remains unknown. The clinical manifestations of PCS are various including chronic pelvic pain (CPP), voiding disturbances, or ureteral obstruction. Imaging modality, such as ultrasonography, computed tomography (CT scan), magnetic resonance imaging (MRI), and venography, are needed to confirm and exclude the differential diagnosis. Currently, American venous forum guidelines recommended endovascular therapy which is percutaneous embolization as the first option therapy of PCS. Here, we reported a 35-year-old woman with PCS who underwent successful percutaneous embolization therapy. © 2021. International College of Angiology. All rights reserved. |
chronic pelvic pain; multiparous woman; pelvic congestion syndrome; percutaneous embolization; venography |
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Thieme Medical Publishers, Inc. |
10611711 |
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Article |
Q3 |
293 |
15070 |
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708 |
Fajar Marta K., Moegni F. |
57270493200;55450456100; |
Level of agreement and acceptance of the 20-Minute versus 60-Minute sanitary pad test as a method for measuring the severity of stress urinary incontinence: randomised crossover trial |
2021 |
Journal of Obstetrics and Gynaecology |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115614159&doi=10.1080%2f01443615.2021.1951689&partnerID=40&md5=937e03ea21fd672e116e87581915560c |
Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University/Sanglah Hospital, Denpasar, Indonesia; Reconstructive Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Fajar Marta, K., Department of Obstetrics and Gynecology, Faculty of Medicine Udayana University/Sanglah Hospital, Denpasar, Indonesia; Moegni, F., Reconstructive Urogynecology Division, Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia/Dr.Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
We aimed to measure the level of agreement and acceptance ratio of the 20-minute versus 60-minute sanitary pad test in female patients with stress urinary incontinence (SUI). This is one-sample cross-experimental design. SUI patients at the Urogynecology Outpatient Clinic at Cipto Mangunkusumo Hospital in Jakarta, Indonesia were consecutively enrolled as participants. We first administered the 20-minute test, followed by the 60-minute test, or vice versa, within 1 week. The participants did not know the type of test performed or asked during the interview. Random Number Generator software by stattrek.com was used to determine which test was performed first for each participant. Participants were interviewed using a questionnaire at the end of each test. The 20-minute sanitary pad test exhibited a good level of agreement with the 60-minute sanitary pad test (kappa R = 0.84). Forty-two respondents (84.0%) reported that they were “satisfied” with the 20-minute sanitary pad test and eight respondents (16.0%) reported that they were “very satisfied”. There was a good agreement between the 20-minute and 60-minute sanitary pad test for assessing the severity of SUI. The 20-minute sanitary pad test achieved a relatively higher level of participant satisfaction.Impact statementWhat is already known on this subject? Patients at the Urogynecology Outpatient Clinic at Cipto Mangunkusumo Hospital have a positive acceptance in the 20-minute and 60-minute sanitary pad test for assessing the severity of SUI. What do the results of this study add? From this result, the authors considered that this method can help in assessing the severity of SUI, especially in Indonesia. What are the implications of these findings for clinical practice and/or further research? As these findings, the authors think that they might be useful as a standard of assessed the severity of SUI. This method does not harmful and easy to apply for every patient with SUI. © 2021 Informa UK Limited, trading as Taylor & Francis Group. |
agreement; Pad test; satisfaction; stress urinary incontinence |
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Taylor and Francis Ltd. |
01443615 |
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Article |
Q3 |
390 |
12371 |
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711 |
Atmakusuma T.D., Tenggara J.B. |
57216961785;26028154300; |
Correlation of transferrin saturation and serum ferritin with bone mass density in adult transfusion dependent beta-thalassemia patients |
2021 |
Journal of Blood Medicine |
12 |
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827 |
832 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115292368&doi=10.2147%2fJBM.S328547&partnerID=40&md5=136e30d4eafe0cf460ffe633d41e4fd8 |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tenggara, J.B., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Division of Hematology-Medical Oncology, Department of Internal Medicine, MRCCC Siloam Hospital Jakarta, Jakarta, Indonesia |
Background: The use of regular blood transfusions and iron chelation therapy to treat thalassemia has improved survival and increased the incidence of osteoporosis. Moreover, iron toxicity is one of the contributing factors that reduce bone mass density in adult transfusion-dependent beta-thalassemia patients. Therefore, this study aims to determine the proportion of low bone mass density in adult thalassemia patients and transferrin saturation, as well as serum ferritin, which correlates to the skeletal condition. Methods: This is a cross-sectional study conducted in Thalassemia and Hematology Medical Oncology Clinics of Cipto Mangunkusumo Hospital in March 2016. The anthropo-metric data and hemoglobin levels were obtained before transfusion. Subsequently, the average ferritin levels, bone mineral density, and radiographic results were obtained. Results: The percentage of adult thalassemia major and intermedia patients with low bone mass density was 68%. Also, there was a weak inverse correlation between bone mass density and transferrin saturation (r = −0.329, p = 0.01), while no correlation was shown between bone mass density and ferritin (r = −0.088, p = 0.504). The transferrin saturation cutoff point value used to distinguish the incidence of low and normal bone density in patients with transfusion-dependent beta-thalassemia was 89.5%. In addition, there was weak correlation between Singh index and bone mass density (r = 0.273, p = 0.038). Conclusion: Among the transfusion-dependent beta-thalassemia patients, 68% had low bone mass density, which inversely correlated to transferrin saturation. Furthermore, the cutoff value of transferrin saturation to differentiate the incidence of low and normal bone density in thalassemia major compared to thalassemia intermedia was 89.5%. Singh Index correlates weakly with bone mass density and might be used to detect low bone mass density in remote healthcare facilities. © 2021 Atmakusuma and Tenggara. |
Bone mass density; Ferritin; Thalassemia; Transferrin; Transfusion dependent beta |
C reactive protein; calcium; chloride; magnesium; phosphate; potassium; sodium; adult; aged; anthropometry; Article; beta thalassemia; blood transfusion; bone densitometry; bone density; correlational study; cross-sectional study; dual energy X ray absorptiometry; female; ferritin blood level; hemoglobin blood level; human; major clinical study; male; radiography; receiver operating characteristic; scoring system; sensitivity and specificity; singh index; transferrin saturation |
Dove Medical Press Ltd |
11792736 |
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Article |
Q3 |
676 |
7401 |
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714 |
S. Sitohang I.B., Legiawati L., Suseno L.S., Safira F.D. |
56734569200;57202804484;57202804092;57261863100; |
Trichloroacetic Acid Peeling for Treating Photoaging: A Systematic Review |
2021 |
Dermatology Research and Practice |
2021 |
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3085670 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115103407&doi=10.1155%2f2021%2f3085670&partnerID=40&md5=9d2fa9a3d858b06aaf4bba3cc0802e10 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
S. Sitohang, I.B., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Legiawati, L., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suseno, L.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Safira, F.D., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Photoaging can significantly contribute to lower quality of life. Medium-deep peeling using trichloroacetic acid allows controlled keratocoagulation through the dermis and into the dermal papillary layer that is effective for skin rejuvenation. The purpose of this article is to give updates regarding the efficacy, possible adverse events, and patient satisfaction of trichloroacetic acid (TCA) peeling for skin rejuvenation by assessing various photoaging parameters. A systematic review of prospective trial articles collected from PubMed, MEDLINE, EMBASE, Cochrane, and Scopus databases was conducted on November 2, 2020. Treatment efficacy was assessed based on the photoaging parameters used by each study. Adverse events and patient satisfaction as the secondary outcome were assessed based on patients-perceived improvements. Five studies included three randomized comparison studies and two prospective cohort studies. These studies show that TCA peeling significantly improve the cosmesis of photoaged facial skin. Low concentration is effective for superficial sun damage. Medium-depth peels using a higher concentration of TCA or as combination therapy are effective as skin resurfacing agents to reduce wrinkles. Some adverse effects may occur but usually resolve within weeks. Overall patients were satisfied with the treatment result. An equivalent basic skin preparation such as topical retinoic acid skin priming prior to intervention is necessary for more objective comparison. Further research studies with a larger sample size and longer follow-up period are required. This evidence suggests that TCA peeling is effective in photoaging treatment, either as monotherapy or as combination therapy with other modalities. © 2021 Irma Bernadette S. Sitohang et al. |
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melanin; trichloroacetic acid; actinic keratosis; adult; bacterial superinfection; burning sensation; chemexfoliation; cohort analysis; edema; erythema; female; human; hydration status; hyperpigmentation; hypopigmentation; male; monotherapy; outcome assessment; pain; patient satisfaction; photoaging; quality of life; randomized controlled trial (topic); Review; systematic review; treatment outcome; wrinkle |
Hindawi Limited |
16876113 |
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Review |
Q3 |
456 |
10893 |
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717 |
Kadharusman M.M., Antarianto R.D., Hardiany N.S. |
57222724597;57190862806;57192910605; |
A review of the impact of calorie restriction on stem cell potency |
2021 |
Malaysian Journal of Medical Sciences |
28 |
4 |
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5 |
13 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114744628&doi=10.21315%2fmjms2021.28.4.2&partnerID=40&md5=f082ca9d61a167cf3fec646a0e6012b7 |
Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Kadharusman, M.M., Undergraduate Program in Medical Sciences, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Antarianto, R.D., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hardiany, N.S., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Calorie restriction (CR) prolongs lifespan in various species and also minimises pathologies caused by aging. One of the characteristics seen in age-related pathologies is stem cell exhaustion. Here, we review the various impacts of CR on mammalian health mediated through stem cell potency in various tissues. This study comprised of a literature search through NCBI, Science Direct, Google Scholar and PubMed, focusing on the impact of CR on pluripotency. In the skeletal muscle, CR acts as an anti-inflammatory agent and increases the presence of satellite cells endogenously to improve regeneration, thus causing a metabolic shift to oxidation to meet oxygen demand. In the intestinal epithelium, CR suppresses the mechanistic target of rapamycin complex 1 (mTORC1) signalling in Paneth cells to shift the stem cell equilibrium towards self-renewal at the cost of differentiation. In haematopoiesis, CR prevents deterioration or maintains the function of haematopoietic stem cells (HSCs) depending on the genetic variation of the mice. In skin and hair follicles, CR increases the thickness of the epidermis and hair growth and improves hair retention through stem cells. CR mediates the proliferation and self-renewal of stem cells in various tissues, thus increasing its regenerative ability. © Penerbit Universiti Sains Malaysia, 2021. |
Calorie restriction; Pluripotency; Stem cell |
apoptosis; caloric restriction; cell differentiation; cell proliferation; deterioration; epidermis; fluorescence activated cell sorting; gene expression; genetic variation; hair follicle; hematopoietic stem cell; insulin sensitivity; intestine epithelium; microenvironment; nonhuman; oxidative phosphorylation; oxidative stress; oxygen consumption; physical activity; regenerative ability; Review; signal transduction; skeletal muscle; stem cell; thermal conductivity; upregulation |
Penerbit Universiti Sains Malaysia |
1394195X |
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Review |
Q3 |
394 |
12287 |
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719 |
Habiburrahman M., Ariq H., Yusharyahya S.N. |
57204537114;57252668400;57211780941; |
The role of lipid and the benefit of statin in augmenting rifampicin effectivity for a better leprosy treatment |
2021 |
Open Access Macedonian Journal of Medical Sciences |
9 |
F |
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246 |
259 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114611520&doi=10.3889%2foamjms.2021.6263&partnerID=40&md5=1f7a547ae466b610bf3ce7e833b58a56 |
Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
Habiburrahman, M., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Ariq, H., Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia; Yusharyahya, S.N., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Referral Hospital, Jakarta, Indonesia |
BACKGROUND: Although leprosy remains as a serious disease of the skin and nervous system, the current treatment is still lacking in its effectiveness. AIM: This literature review will explore the association of lipid and leprosy, as well as the potential of statin and other lipid-lowering agents as adjunctive drugs to combat leprosy. MATERIALS AND METHODS: Articles were searched through the PubMed, EBSCOhost, and Google Scholar with the keywords: immunomodulation, lipid-body, lipids, leprosy, Mycobacterium leprae, pathogenesis, rifampin or rifampicin, and statins. A manual searching is also carried out to find an additional relevant information to make this literature review more comprehensive. RESULTS: The literatures showed that lipids are highly correlated with leprosy through alterations in serum lipid profile, metabolism, pathogenesis, and producing oxidative stress. Statins can diminish lipid utilization in the pathogenesis of leprosy and show a mycobactericidal effect by increasing the effectiveness of rifampicin and recover the function of macrophages. In addition, Statins have anti-inflammatory properties which may aid in preventing type I and II reactions in leprosy. Standard multidrug therapy might reduce the efficacy of statins, but the effect is not clinically significant. The statin dose-response curve also allows therapeutic response to be achieved with minimal dose. CONCLUSION: The various pleiotropic effects of statins make it a potential adjunct to standard treatment for leprosy in the future. © 2021 Muhammad Habiburrahman, Haekal Ariq, Shannaz Nadia Yusharyahya. |
Anti-inflammatory; Bactericidal; Leprosy; Lipids; Rifampicin; Statins |
hydroxymethylglutaryl coenzyme A reductase inhibitor; interleukin 10; mevalonic acid; rifampicin; Article; human; immunomodulation; inflammation; lepromatous leprosy; leprosy; lipid metabolism; macrophage; macrophage function; Mycobacterium leprae; oxidative stress; phagocytosis; physiological stress; pleiotropy; polypharmacy; sensitivity and specificity; systematic review; treatment response; tuberculoid leprosy |
Scientific Foundation SPIROSKI |
18579655 |
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Article |
Q3 |
288 |
15252 |
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720 |
Hariyanto A.D., Permata T.B.M., Gondhowiardjo S.A. |
57253039400;57197808751;6508327402; |
Role of CD4+CD25+FOXP3+ TReg cells on tumor immunity |
2021 |
Immunological Medicine |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114605951&doi=10.1080%2f25785826.2021.1975228&partnerID=40&md5=dee345614c66584e8dcc9d94211b7f1f |
Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Hariyanto, A.D., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Permata, T.B.M., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gondhowiardjo, S.A., Faculty of Medicine, Department of Radiotherapy, Universitas Indonesia/Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Not all T cells are effector cells of the anti-tumor immune system. One of the subpopulations of CD4+ T cells that express CD25+ and the transcription factor FOXP3, known as Regulator T cells (TReg), plays an essential role in maintaining tolerance and immune homeostasis preventing autoimmune diseases, minimalize chronic inflammatory diseases by enlisting various immunoregulatory mechanisms. The balance between effector T cells (Teff) and regulator T cells is crucial in determining the outcome of an immune response. Regarding tumors, activation or expansion of TReg cells reduces anti-tumor immunity. TReg cells inhibit the activation of CD4+ and CD8+ T cells and suppress anti-tumor activity in the tumor microenvironment. In addition, TReg cells also promote tumor angiogenesis both directly and indirectly to ensure oxygen and nutrient transport to the tumor. There is accumulating evidence showing a positive result that removing or suppressing TReg cells increases anti-tumor immune response. However, depletion of TReg cells will cause autoimmunity. One strategy to improve or restore tumor immunity is targeted therapy on the dominant effector TReg cells in tumor tissue. Various molecules such as CTLA-4, CD4, CD25, GITR, PD-1, OX40, ICOS are in clinical trials to assess their role in attenuating TReg cells’ function. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of the Japanese Society of Clinical Immunology. |
anti-tumor immunity; immunotherapy; regulatory T cells; TReg; TReg-targeting therapy |
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Taylor and Francis Ltd. |
25785826 |
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Review |
Q3 |
419 |
11666 |
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722 |
Haifa G.Z., Wardoyo S. |
57249982200;57211106608; |
Surgical management in tetralogy of Fallot with rare unilateral pulmonary anomalies: A literature review |
2021 |
Asian Cardiovascular and Thoracic Annals |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114401204&doi=10.1177%2f02184923211039732&partnerID=40&md5=777078337b7532f398e346223b7685f6 |
Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Haifa, G.Z., Training Program of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia; Wardoyo, S., Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo General Hospital, Indonesia |
Tetralogy of Fallot with unilateral pulmonary anomalies such as the unilateral absence of pulmonary artery or unilateral pulmonary agenesis is an extremely rare complex congenital heart anomaly. There is no established surgical algorithm for tetralogy of Fallot with concomitant unilateral pulmonary anomalies. This condition is still challenging, especially in the surgical field. In this review we also present our experiences in our center, Dr Cipto Mangunkusumo General Hospital, Jakarta, Indonesia. This literature review aimed to discuss systematic treatment options and hoped to help the decision-making process when surgeons face these rare anomalies. © The Author(s) 2021. |
Tertralogy of Fallot; unilateral absence of pulmonary artery; unilateral pulmonary agenesis; unilateral pulmonary anomalies |
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SAGE Publications Inc. |
02184923 |
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Review |
Q3 |
203 |
19132 |
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