No records
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902 |
Bahtiar A., Miranda A.J., Arsianti A. |
35365874400;57221531432;36124567000; |
The effect of artocarpus altilis (parkinson) fosberg extract supplementation on kidney ischemia-reperfusion injury rat |
2021 |
Pharmacognosy Journal |
13 |
1 |
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150 |
154 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099365078&doi=10.5530%2fpj.2021.13.21&partnerID=40&md5=13b866767b1597a22566e8ac646a0b9f |
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Bahtiar, A., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Miranda, A.J., Department of Pharmacology and Toxicology, Faculty of Pharmacy, Universitas Indonesia, Kampus UI Depok, West Java, 16424, Indonesia; Arsianti, A., Department of Medicinal Chemistry, Faculty of Medicine, Universitas Indonesia, Kampus UI Salemba, Jakarta, Indonesia |
Background: Acute kidney injury (AKI) is a kidney disease resulting in high morbidity and mortality levels in humans. One of the disorders classified as AKI is ischemia-reperfusion injury (IRI), characterized by two phases. The first phase is Ischemia in the kidneys due to obstruction of the renal arteries or veins, followed by the second phase, which is the occurrence of reperfusion with blood flowing back in the renal arteries veins. The aim of this current research is to analyze the efficacy of Artocarpus altilis on Kidney ischemia-reperfusion model rats. Methods: To this end, first, we established Ischaemia-reperfusion kidney injury rat. We then evaluated the Artocarpus altilis extract on IRI model rats. A total of 36 rats have grouped into six groups. Group I is the Sham group, Group II is the negative control group, Group III is the positive control group (vitamin C 100 mg/kg BW), Group IV is Dose I of Artocarpus altilis extract 50 mg/kg BW), Group V is Dose II Artocarpus altilis extract 100 mg/kg BW), Group VI is Dose III Artocarpus altilis extract 200 mg/kg BW). The vitamin C and Artocarpus altilis extract administered 14 days before and after Ischemia-reperfusion treatment. At day 0, Ischemia was made by bilateral renal pedicle clamping method for 30 minutes, sacrificed 14 days after reperfusion. The blood and histology samples were collected on day 0, a day after reperfusion, at 24 hrs after reperfusion, at 48 hrs after reperfusion, and 14 days after treatment. Results: The clamping duration of 30 minutes leads to achieving the most representative clinical IRI conditions. It shows the most significant recovery of injury conditions within the 14-day reperfusion period in IRI animal models, making it ideal for IRI operations for the preliminary test. The administration of 100 mg/kg BW of Artocarpus altilis extract could reduce the malondialdehyde plasma compared with the sham group. The SOD and Catalase activity showed improvement after reperfusion. Conclusion: Artocarpus altilis extracts showed antioxidant activity to prevent the kidney from ischemia-reperfusion injury by modulated SOD and Catalase. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Acute kidney disease; Artocarpus altilis (Parkinson) Fosberg; Free radicals; Reperfusion injury; Sukun |
antiinflammatory agent; antioxidant; Artocarpus altilis extract; ascorbic acid; catalase; creatinine; malonaldehyde; nitrogen; plant extract; protective agent; superoxide dismutase; unclassified drug; urea; animal experiment; animal model; animal tissue; antiinflammatory activity; antioxidant activity; Article; blood sampling; controlled study; creatinine blood level; dose response; drug efficacy; enzyme activity; enzyme blood level; glomerulus filtration rate; histopathology; male; nonhuman; rat; renal ischemia reperfusion injury; renal protection; supplementation; treatment duration; urea nitrogen blood level |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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903 |
Kusmardi K., Wiyarta E., Estuningtyas A., Sahar N., Midoen Y.H., Tedjo A. |
56966625300;57221521342;55650360200;57212464367;57197805109;57189320451; |
Potential of phaleria macrocarpa leaves ethanol extract to upregulate the expression of caspase-3 in mouse distal colon after dextran sodium sulphate induction |
2021 |
Pharmacognosy Journal |
13 |
1 |
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23 |
29 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099343021&doi=10.5530%2fpj.2021.13.4&partnerID=40&md5=8dd1b8ac126d5a96f41668c2f3066c1f |
Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Department Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Kusmardi, K., Department of Anatomic Pathology, Drug Development Research Cluster, Human Cancer Research Center, IMERI, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Wiyarta, E., Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Estuningtyas, A., Department of Pharmacology and Therapeutic, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Sahar, N., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Midoen, Y.H., Department of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia; Tedjo, A., Department Medical Chemistry, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, Indonesia |
Ulcerative colitis (UC) is a part of incurable chronic inflammatory disease that has gained importance over the past few decades. A lot of research has been done to find effective treatments for UC, one of which is herbal medicine. Phaleria macrocarpa (PM), an Indonesian native plant, is thought to be an alternative therapy for UC because of its anti-inflammatory properties. Therefore, in this research, Phaleria macrocarpa Leaves Ethanol Extract (PMLEE) is used to assess its effect on UC by using Caspase-3 as apoptosis marker. PMLEE was made from dried material of PM that undergo maceration. Animals were separated into six groups: normal, negative control, positive control, and PMLEE groups (100, 200, 300 mg/kgBW). PMLEE was then injected to BALB/c mice that have been induced by dextran sodium sulphate (DSS) for 7 consecutive days. DSS is used to model UC in mice colon tissue. All animals were sacrificed and their colons were collected then stained with anti-Caspase-3. The stained sections were subsequently examined with ImageJ based on color intensity which generated H-Score as the results. Based on H-Score of each group, PMLEE 300mg has significantly upregulate the expression of Caspase-3 compare to the negative control (p=0.015). PMLEE also has a tendency to be dose dependent based on the significant difference between PMLEE doses. Therefore, it concludes that PMLEE is able to upregulate the expression of Caspase-3 in colon cells as in this study it was directly proportional. © 2021 Phcogj.Com. This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license. |
Apoptosis; Inflammation; Mahkota Dewa; Ulcerative colitis |
acetylsalicylic acid; alcohol; antiinflammatory agent; apoptotic protease activating factor 1; caspase 3; cytochrome c; dextran sulfate; Phaleria macrocarpa extract; plant extract; unclassified drug; animal cell; animal experiment; animal model; animal tissue; antiinflammatory activity; apoptosis; Article; cell death; cell proliferation; colon tissue; controlled study; descending colon; dysplasia; medicinal plant; mitochondrion; mouse; nonhuman; Phaleria macrocarpa; plant leaf; protein expression; ulcerative colitis; upregulation |
EManuscript Technologies |
09753575 |
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Article |
Q3 |
268 |
15961 |
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No records
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743 |
Soeroso N.N., Ananda F.R., Pradana A., Tarigan S.P., Syahruddin E., Noor D.R. |
57201670271;57201666959;57202578193;6602815057;6507688750;57214096801; |
The absence of mutations in the exon 2 kras gene in several ethnic groups in north sumatra may not the main factor for lung cancer |
2021 |
Acta Informatica Medica |
29 |
2 |
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108 |
112 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111477707&doi=10.5455%2fAIM.2021.29.108-112&partnerID=40&md5=4854ca99a072394cbd039b5f66172820 |
Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia |
Soeroso, N.N., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Ananda, F.R., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Pradana, A., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Tarigan, S.P., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Sumatera Utara, Indonesia; Syahruddin, E., Thoracic Oncology Division, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia; Noor, D.R., Human Cancer Research Center, Indonesian Medical Education and Research Institute, Universitas Indonesia, Indonesia |
Background: Rat Sarcoma (RAS) protein encoded Guanosine Triphosphate (GTP-ase) activity, known as a switch of cell proliferation. The mutation of this protein alters the early stage of carcinogenesis and along with the interaction with other oncogene drivers and environmental factors affect the clinical characteristics and prognosis in cancer patients, particularly lung cancer. Objective: This study aims to determine the Kristen Rat Sarcoma (KRAS) mutation in lung cancer patients in North Sumatera and evaluate factors that might contribute in the development of lung cancer in the absence of KRAS mutation. Methods: This was a retrospective cohort study enrolled 44 subjects age > 18 year with the diagnosis of lung cancer. Histopathology preparation was obtained from surgery, bronchoscopy, and percutaneus needle biopsy then formed as paraffin-block. KRAS mutation was analyzed using Polymerase Chain Reaction (PCR) method with specific primer of exon 2 for evaluating the expression of RAS protein then continued with Sanger Sequencing Method at 12th and 13th codon. Results: The majority of subjects were male, age > 40 years old, bataknese, heavy smoker, with Adenocarcinoma. Almost all the subjects showed the expression of exon 2 of RAS protein in PCR examinations. However, Sequencing analysis using Bioedit Software, BLASTs and Finch T showed GGT GGC as protein base 219-224 which represented 12th and 13th Codon 12 and 13. The results interpreted there was no mutations of exon 2 of KRAS in North Sumatera Population. Conclusion: The absence of KRAS mutation in exon 2 in several ethnics in North Sumatera populations was not the main factors of lung cancer. © 2021 Noni Novisari Soeroso, Fannie Rizki Ananda, Andika Pradana, Setia Putra Tarigan, Elisna Syahruddin, Dimas Ramadhian Noor |
Ethnic variation; Exon 2; Indonesian; KRAS mutation; Lung cancer |
K ras protein; adult; age; Article; bronchoscopy; cancer diagnosis; cancer patient; cancer surgery; clinical article; cohort analysis; controlled study; ethnic difference; female; gender; gene expression; gene mutation; histopathology; human; lung adenocarcinoma; lung cancer; male; needle biopsy; polymerase chain reaction; retrospective study; Sanger sequencing; smoking |
Avicena Publishing |
03538109 |
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Article |
Q3 |
267 |
15980 |
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No records
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516 |
Rosa B.A., Snowden C., Martin J., Fischer K., Kupritz J., Beshah E., Supali T., Gankpala L., Fischer P.U., Urban J.F., Jr., Mitreva M. |
15519661800;57215576664;56537265100;55807725800;57211116674;6506448106;6602742029;55801653400;23567680200;7202366458;6507392205; |
Whipworm-Associated Intestinal Microbiome Members Consistent Across Both Human and Mouse Hosts |
2021 |
Frontiers in Cellular and Infection Microbiology |
11 |
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637570 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103118895&doi=10.3389%2ffcimb.2021.637570&partnerID=40&md5=27cf0d3a842448c6a8e6d26ccd8dd43e |
Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD, United States; Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Public Health and Medical Research, National Public Health Institute of Liberia, Charlesville, Liberia; Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States; McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, United States |
Rosa, B.A., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Snowden, C., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Martin, J., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Fischer, K., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Kupritz, J., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Beshah, E., U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD, United States; Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Gankpala, L., Public Health and Medical Research, National Public Health Institute of Liberia, Charlesville, Liberia; Fischer, P.U., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Urban, J.F., Jr., U.S. Department of Agriculture, Agricultural Research Service, Beltsville Agricultural Research Center, Animal Parasitic Diseases Laboratory, Beltsville, MD, United States; Mitreva, M., Division of Infectious Diseases, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States, Department of Genetics, Washington University School of Medicine, St. Louis, MO, United States, McDonnell Genome Institute, Washington University in St. Louis, St. Louis, MO, United States |
The human whipworm Trichuris trichiura infects 289 million people worldwide, resulting in substantial morbidity. Whipworm infections are difficult to treat due to low cure rates and high reinfection rates. Interactions between whipworm and its host’s intestinal microbiome present a potential novel target for infection control or prevention but are very complicated and are identified using inconsistent methodology and sample types across the literature, limiting their potential usefulness. Here, we used a combined 16S rRNA gene OTU analysis approach (QIIME2) for samples from humans and mice infected with whipworm (T. trichiura and T. muris, respectively) to identify for the first time, bacterial taxa that were consistently associated with whipworm infection spanning host species and infection status using four independent comparisons (baseline infected vs uninfected and before vs after deworming for both humans and mice). Using these four comparisons, we identified significant positive associations for seven taxa including Escherichia, which has been identified to induce whipworm egg hatching, and Bacteroides, which has previously been identified as a major component of the whipworm internal microbiome. We additionally identified significant negative associations for five taxa including four members of the order Clostridiales, two from the family Lachnospiraceae, including Blautia which was previously identified as positively associated with whipworm in independent human and mouse studies. Using this approach, bacterial taxa of interest for future association and mechanistic studies were identified, and several were validated by RT-qPCR. We demonstrate the applicability of a mouse animal model for comparison to human whipworm infections with respect to whipworm-induced intestinal microbiome disruption and subsequent restoration following deworming. Overall, the novel cross-species analysis approach utilized here provides a valuable research tool for studies of the interaction between whipworm infection and the host intestinal microbiome. © Copyright © 2021 Rosa, Snowden, Martin, Fischer, Kupritz, Beshah, Supali, Gankpala, Fischer, Urban and Mitreva. |
animal model; helminth; intestinal microbiota; microbiome; whipworm |
albendazole; ivermectin; mebendazole; RNA 16S; RNA 16S; adult; ancylostomiasis; Article; Bacteroides; Blautia; child; Clostridiales; DNA extraction; Escherichia; feces analysis; female; gene sequence; human; infection control; intestine flora; Lachnospiraceae; male; molecular genetics; morbidity; nonhuman; polymerase chain reaction; real time polymerase chain reaction; reverse transcription polymerase chain reaction; taxonomy; trichuriasis; Trichuris muris; Trichuris trichiura; animal; genetics; microflora; mouse; trichuriasis; Trichuris; Animals; Gastrointestinal Microbiome; Humans; Mice; Microbiota; RNA, Ribosomal, 16S; Trichuriasis; Trichuris |
Frontiers Media S.A. |
22352988 |
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33777847 |
Article |
Q1 |
1812 |
1607 |
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No records
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630 |
Indrasari M., Kusdhany L.S., Maharani D.A., Ismail R.I. |
57193349086;55301180900;32867911000;55996895500; |
Development of the Indonesian version of the Oral Health Impact Profile in Edentulous Prosthodontic Patients |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1531 |
1536 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123868913&partnerID=40&md5=29207b68d1256bd93f9c88f61071a0dd |
Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Indrasari, M., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusdhany, L.S., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Maharani, D.A., Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Oral Health Impact Profile in Edentulous (OHIP-EDENT) is an instrument that measures several aspects of oral health-related quality of life as it relates to edentulous patients. Numerous studies have shown that edentulous has an impact on an individual's quality of life. This instrument aids in detecting the impact of oral health on the quality of life of patients who wear prostheses. The purpose of this study was to develop the OHIP-EDENT in Indonesian version for edentulous patients. The questionnaire was translated into Indonesian, back-translated, pre-tested, and crossculturally adapted. The qualitative interviews were carried out of 12 subjects, 46-77 years old, with diverse levels of formal education. All subjects were undergoing complete or single complete denture treatments at Dental Hospital Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. Since an expert committee agreed upon the original version, the questionnaire was translated, back-translated, and the outcomes of the qualitative interviews were used to finalize the revised instrument. After the pretesting, the adapted Indonesian OHIP-EDENT can be used as an instrument that is easy to use by edentulous patients undergoing complete or single denture treatments. Further analyses of the questionnaire's psychometric properties are needed to confirm its validity and reliability in target settings. © 2021,Journal of International Dental and Medical Research.All Rights Reserved |
Complete denture; Cross-cultural adaptation; Edentulous; Oral health; Quality oflife |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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631 |
Siahaan P.E.A., Kusumawardhani A.A.A.A., Ismail R.I., Malik K. |
57435237600;14633768700;55996895500;57204114533; |
Effectiveness of the "Emotion Recognition" Music Therapy Module in Schizophrenia Patients: A Quasi Experimental Study |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1722 |
1726 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123861310&partnerID=40&md5=d39caa1cc0263ce0e3e32f24151e3bb2 |
Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
Siahaan, P.E.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Kusumawardhani, A.A.A.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Ismail, R.I., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Malik, K., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
One of the deficit domains of social cognition in schizophrenia patients is emotion recognition. Negative emotion recognition deficits, such as emotional deficits of fear, anger, and sadness already exist in the first episode of schizophrenia. Music as therapy is known to be beneficial for emotional improvement, as well as the emotional experience of patients with schizophrenia. This study was aimed to assess the validity and effectiveness of a music therapy module “emotion recognition” in improving recognition of basic emotions in patients with schizophrenia. This quasi experimental study was conducted at the adult outpatient clinic at Cipto Mangunkusumo Hospital. The research was conducted in 2 steps. The first step to assess the validity of the module by calculate the I-CVI, S-CVI, and CVR of validity test and the second step to implement the music therapy module to the patient. This study assessed 15 subjects of schizophrenic remission patients who attended music therapy for 10 sessions conducted from March 2020 to July 2020. Subjects were assessed pre and post music therapy test results to see the effectivity of the module as seen by improvements in recognition of 5 basic emotions (happy, sad, anger, fear, tender) using the Mcnemar statistical test. The results of the validity test of the module showed the I-CVI of 0.98, S-CVI of 0.95, and CVR of 0.97. There was a significant improvement in the emotional deficits of fear and anger, with an increase in the pre and post music therapy test scores with a p-value 0.016 in the anger emotion and 0.008 in fear emotion, but not significant in the happy, sad, and tender emotions (p-value> 0.05). The emotion recognition music therapy module has good content validity, and effectiveness in emotion recognition of some of the basic emotions of remission schizophrenia patients, especially the emotion recognition of fear and anger. © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Effectivity; Emotion recognition; Music therapy; Schizophrenia |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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632 |
Arozal W., Barinda A.J., Monayo E.R., Aulia R. |
32067462200;57196373933;56955565900;56955797500; |
Mangiferin Attenuates Doxorubicin-Induced Nephrotoxicity in Rats Through Reduction of Oxidative Stress |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1667 |
1674 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123841744&partnerID=40&md5=1da2ad818beb007235cddc77a1b487fe |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Barinda, A.J., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Monayo, E.R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Aulia, R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Doxorubicin (DOX) has been widely used in the clinical setting for malignancy treatment.However, it also induces toxicity in a vital organ such as the kidney. Several studies suggest theformation of an iron anthracycline complex which produces free radicals plays an important role innephrotoxicity.Mangiferin (MGF), a xanthone derivate, exhibits as an iron chelator and antioxidant activitythrough a free radical scavenger activity. We analyzed the effect of MGF to prevent DOX inducednephrotoxicity. Male Sprague-Dawley rats were administered MGF orally every day for five weeks,with 50 and 100 mg/kg BW together with DOX. Renal failure and dyslipidemia were detected in theDOX groups in association with increased malondialdehyde (MDA) levels in plasma and kidney anddecreased superoxide dismutase (SOD) and glutathione (GSH) levels in kidney. Of note, cotreatmentwith MGF improved renal dysfunction caused by doxorubicin as shown by theamelioration plasma albumin, urea and creatinine levels, and proteinuria. MGF also diminishedover-production of MDA levels, thus enhanced antioxidant activity such as SOD and GSH in thekidney.Our study opens the perspective to clinical studies for consideration of MGF as a potentialchemoprotectant nutraceutical in the combination chemotherapy with DOX to limit its nephrotoxicity © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Doxorubicin; Kidney; Mangiferin; Toxicity |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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691 |
Wulandari P., Kusdhany L.S., Masulili S.L.C., Puspitadewi S.R., Baziad A. |
57201898722;55301180900;55855884100;57203025561;6506424401; |
The Relationship between Tooth Loss and Gingival Status with Oral Hygiene in Postmenopausal Women |
2021 |
Journal of International Dental and Medical Research |
14 |
3 |
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1057 |
1063 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116900014&partnerID=40&md5=2c741b2f8115ddf2d39627ed1a432c91 |
Department of Periodontics, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Department of Prosthodontics, Faculty of Dentistry, Universitas Prof. Dr.Moestopo, Jakarta, Indonesia; Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Wulandari, P., Department of Periodontics, Faculty of Dentistry, Universitas Sumatera Utara, Medan, Indonesia; Kusdhany, L.S., Department of Prosthodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Masulili, S.L.C., Department of Periodontics, Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia; Puspitadewi, S.R., Department of Prosthodontics, Faculty of Dentistry, Universitas Prof. Dr.Moestopo, Jakarta, Indonesia; Baziad, A., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Poor oral hygiene can lead to further periodontal damage, especially in the postmenopausal pre-elderly who are deficient in estrogen. This study aimed to analyze the relationship between socio-demographic factors, tooth loss and gingival status on oral hygiene in postmenopausal women aged 45 until 59 years old. This study was a cross-sectional study of postmenopausal women aged 45 until 59 years old with periodontitis in Jakarta Indonesia Information about age, education level and duration of menopause were obtained through interviews and history taking. Clinical examination was performed to check the oral hygiene index, the number of tooth loss and gingival status, namely the plaque index, papillary bleeding index. The results of this study showed that subjects who lost their teeth ≥4 (57.10%) had poor oral hygiene compared to <4 (42.90%) however, the Spearman correlation test showed that there was no significant relationship between the number of tooth losses (p = 0.907) with oral hygiene index. Pearson correlation test showed that there was a significant relationship between gingival status as measured by plaque index and papillary bleeding index (p=0.001) with the oral hygiene index. The conclusion of this study, postmenopausal women are prone to experience problems in the oral cavity, especially periodontal tissue. Socio-demographic factors such as age, level of education and also the length of menopause were not significantly associated with oral hygiene; however, there was a significant relationship between gingival status and oral hygiene in postmenopausal women aged 45 until 59 years old © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Estrogen; Oral hygiene index; Periodontal; Postmenopausal; Tooth loss |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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693 |
Hardiany N.S., Kirana A.N., Prafiantini E. |
57192910605;57222361321;57193088368; |
Oxidative Stress in the Elderly with Hypertension: A Cross-Sectional Study |
2021 |
Journal of International Dental and Medical Research |
14 |
3 |
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1246 |
1250 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116866069&partnerID=40&md5=3e8984a3a06a6eef33f0305c742b648f |
Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Hardiany, N.S., Department of Biochemistry & Molecular Biology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Center of Hypoxia & Oxidative Stress Studies, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kirana, A.N., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Prafiantini, E., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Hypertension is a major health problem, especially in the elderly, because it serves as a risk I factor for cardio- and cerebrovascular diseases. The involvement of oxidative stress in hypertension I has been shown in animal studies. However, the data about oxidative stress in humans with I hypertension, especially in the elderly, are still limited. The aim of this study is to analyze oxidative stress by measuring carbonyl and superoxide I dismutase (SOD) in hypertensive elderly. It was a cross-sectional study conducted on 70 elderly I subjects, 35 subjects with hypertension and 35 subjects with normotension, in Jakarta, Indonesia. I Subjects were classified into the hypertensive group if their systolic blood pressure was > 130 I mmHg or their diastolic blood pressure was > 80 mmHg according to American guidelines. Plasma I carbonyl and SOD were measured using a spectrophotometer. Correlation analysis and I Independent T-test were used for statistical analysis. Carbonyl was significantly higher, while SOD I was significantly lower in hypertensive elderly compared to the control. There was a negative I correlation between SOD and systolic blood pressure, as well as a weak positive correlation I between carbonyl and mean arterial pressure. In conclusion, a significant increase of carbonyl and decrease of SOD were detected in I hypertensive elderly, reflecting oxidative stress. © 2021. All Rights Reserved. |
Carbonyl; elderly; hypertension; superoxide dismutase |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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754 |
Setyarini I.B., Manikam N.R.M., Mudjihartini N. |
57226147050;56681219300;57191055759; |
The Effect Vitamin D Supplementation on Severity and Mortality Risk of COVID-19: A Systematic Review |
2021 |
Journal of International Dental and Medical Research |
14 |
2 |
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797 |
805 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110570730&partnerID=40&md5=9bb929e2eeee929828209a53a372f352 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Biochemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Setyarini, I.B., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Manikam, N.R.M., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Mudjihartini, N., Department of Biochemistry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Vitamin D levels are associated with improved immunity dysregulation to prevent worsening of COVID-19 patients. However, studies regarding the effects of vitamin D on COVID-19 patients are still inconsistent. This study aimed to analyze vitamin D supplementation's effect on the severity and mortality risk of COVID-19 patients. Search was conducted in seven databases on September 2020. Studies assessing the topic were included without study design restrictions. Four studies were included in this study. All reported risk of mortality, and three reported of severity degree. Two of the three found patients with vitamin D supplementation had a significantly lower risk of disease. One other found no significant difference, although a higher proportion of severe COVID-19 was recorded in the group without supplementation. Three of the four reported supplementation as a protective factor against mortality in COVID-19 patients. One study reported that vitamin D supplementation group had a higher mortality than the group without, although it has low validity and high risk of bias. In conclusion, there were differences in the severity and mortality risk between COVID-19 patients given vitamin D supplementation and control patients. Vitamin D supplementation is a protective factor in the severity and mortality risk of COVID-19 patients. © 2021, Journal of International Dental and Medical Research, All Rights Reserved. |
COVID-19; Mortality; patients; Vitamin D |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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