No records
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394 |
Abdullah M., Sudrajat D.G., Muzellina V.N., Kurniawan J., Rizka A., Utari A.P., Pribadi R.R., Idrus M.F., Yusra Y., Meilany S., Surandy A., Shatri H., Rinaldi I., Pitoyo C.W., Renaldi K. |
7103393434;54893136100;57223968527;57193251655;57203243658;57113585900;57194732282;57223976376;57220998367;57193709281;57223964417;28767986500;23475122400;26022606900;57190963547; |
The value of anal swab RT-PCR for COVID-19 diagnosis in adult Indonesian patients |
2021 |
BMJ Open Gastroenterology |
8 |
1 |
e000590 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85106611204&doi=10.1136%2fbmjgast-2020-000590&partnerID=40&md5=cc17ce689ac73f1e46021151c9319871 |
Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Abdullah, M., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia, Indonesia Medical Education and Research Institute - Human Cancer Research Center, University of Indonesia Faculty of Medicine, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Sudrajat, D.G., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Muzellina, V.N., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Kurniawan, J., Hepatobilliary Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Rizka, A., Geriatric Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Utari, A.P., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pribadi, R.R., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Idrus, M.F., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region Jakarta, Indonesia; Meilany, S., Research Center for Virology and Cancer Pathobiology, University of Indonesia Faculty of Medicine, Jakarta, Special Capital Region of Jakarta, Indonesia; Surandy, A., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Shatri, H., Psychosomatic and Palliative Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Special Capital Region of Jakarta, Central Jakarta, Indonesia; Rinaldi, I., Hematology and Medical Oncology Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Pitoyo, C.W., Respirology and Critical Care Division, Internal Medicine Department, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia; Renaldi, K., Gastroenterology, Pancreatobilliary, and Endoscopy Division, Internal Medicine Department, Rumah Sakit Umum Pusat Nasional Dr Cipto Mangunkusumo, Central Jakarta, Special Capital Region of Jakarta, Indonesia |
Objective This study will test the performance of the anal swab PCR test when compared with the nasopharyngeal swab PCR test as a diagnostic tool for COVID-19. Design An observational descriptive study which included hospitalised suspected, or probable cases of hopitalised COVID-19 patients, conducted in Dr. Cipto Mangunkusumo National Hospital, Ciputra Hospital, Mitra Keluarga Depok Hospital and Mitra Keluarga Kelapa Gading Hospital, Indonesia. Epidemiological, clinical, laboratory and radiology data were obtained. Nasopharyngeal and anal swabs specimens were collected for SARS-CoV-2 RNA detection. Results We analysed 136 subjects as part of this study. The clinical spectrum of COVID-19 manifesation in this study was typical of hospitalised patients, with 25% classified as mild cases, 14.7% in severe condition and 12.5% of subjects classified as having acute respiratory distress syndrome. When compared with nasopharyngeal swab as the standard specimen for reverse transcription polymerase chain reaction (RT-PCR) detection of SARS-CoV-2 antigen, the sensitivity and specificity of the anal swab was 36.7% and 93.8%, respectively. The positive and negative predictive value were 97.8% and 16.5 %, respectively. The performance of the anal swab remained similar when only the subgroup of patients with gastrointestinal symptoms (n=92, 67.6%) was analysed (sensitivity 40% and specificity 91.7%). Out of all the subjects included in analysis, 67.6% had gastrointestinal symptoms. Similarly, 73.3% of patients in the anal swab-positive group had gastrointestinal symptoms. The two most common gastrointestinal symptoms in the subjects' population were nausea and anorexia. Conclusion Anal swab specimen has low sensitivity (36.7%) but high specificity (93.8%) for detecting SARS-CoV-2 antigen by RT-PCR. Only one additional positive result was found by anal swab among the nasopharyngeal swab-negative group. Anal swab may not be needed as an additional test at the beginning of a patient's diagnostic investigation and nasopharyngeal swab RT-PCR remains as the standard diagnostic test for COVID-19. © 2020 American Society of Mechanical Engineers (ASME). All rights reserved. |
anal; COVID-19; diagnostic virology |
abdominal pain; adult; adult respiratory distress syndrome; anal swab; anorexia; Article; body mass; clinical laboratory; controlled study; coronavirus disease 2019; coughing; COVID-19 testing; current smoker; diagnostic test accuracy study; diarrhea; ex-smoker; female; fever; gastrointestinal symptom; headache; heart disease; hospital patient; human; hypertension; Indonesian; lung disease; major clinical study; malaise; male; mortality rate; nasopharyngeal swab; nausea; non insulin dependent diabetes mellitus; practice guideline; predictive value; priority journal; respiratory tract infection; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat |
BMJ Publishing Group |
20544774 |
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Article |
Q1 |
1240 |
3126 |
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No records
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56 |
Gunardi E.R., Surya R., Syafitri I., Pasidri Y. |
57192910998;56986345100;57195381844;57226151144; |
Impact of one-rod levonorgestrel implant on the blood chemistry profile |
2021 |
Scientific Reports |
11 |
1 |
20141 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116742568&doi=10.1038%2fs41598-021-99801-z&partnerID=40&md5=604f40cda19708636ac9b97fd82f17a7 |
Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
Gunardi, E.R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Surya, R., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Syafitri, I., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Pasidri, Y., Department of Obstetrics and Gynecology, Faculty of Medicine, University of Indonesia—Cipto Mangunkusumo General Hospital, Jakarta, Indonesia |
The aim of this study was to investigate the effect of a one-rod levonorgestrel implant on the blood chemistry profile, including random blood glucose (RBG), haemoglobin (Hb), alanine transferase (ALT), aspartate transferase (AST), and the lipid profile, including total cholesterol, high-density lipoprotein (HDL), low-density lipoprotein (LDL), and triglycerides. This prospective cohort study was conducted at Raden Saleh Clinic, Jakarta, from 2010 to 2012. The implants were inserted subdermally in 30 patients. The subjects were evaluated every 6 month up to 2 years. Bivariate analysis using t-test or Wilcoxon signed rank test was performed for all variables. p < 0.05 was considered a significant value. The Hb, RBG, AST, and lipid profile levels were significantly different before and 6 months after one-rod implant insertion (p < 0.05). However, for 24 months, all of the parameters were still within normal limits and did not differ clinically. One-rod levonorgestrel implant insertion has a minimal effect on all blood chemistry profiles. © 2021, The Author(s). |
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cholesterol; contraceptive agent; high density lipoprotein cholesterol; levonorgestrel; lipid; low density lipoprotein cholesterol; triacylglycerol; adult; blood; blood analysis; drug implant; female; human; phase 2 clinical trial (topic); procedures; prospective study; young adult; Adult; Blood Chemical Analysis; Cholesterol; Cholesterol, HDL; Cholesterol, LDL; Clinical Trials, Phase II as Topic; Contraceptive Agents, Female; Drug Implants; Female; Humans; Levonorgestrel; Lipids; Prospective Studies; Triglycerides; Young Adult |
Nature Research |
20452322 |
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34635768 |
Article |
Q1 |
1240 |
3130 |
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63 |
Irwinda R., Hiksas R., Siregar A.A., Saroyo Y.B., Wibowo N. |
57190855256;57226152029;57226157581;57164888400;15049026900; |
Long-chain polyunsaturated fatty acid (LC-PUFA) status in severe preeclampsia and preterm birth: a cross sectional study |
2021 |
Scientific Reports |
11 |
1 |
14701 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110662198&doi=10.1038%2fs41598-021-93846-w&partnerID=40&md5=f379da0f3a9e78e16af9cc0ca6bb9968 |
Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Irwinda, R., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Hiksas, R., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Siregar, A.A., Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Saroyo, Y.B., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia; Wibowo, N., Maternal Fetal Division, Department of Obstetrics and Gynaecology, Faculty of Medicine, Universitas Indonesia/Cipto-Mangunkusumo Hospital, Jakarta, Indonesia |
Long-Chain Polyunsaturated Fatty Acid (LCPUFA) is essential throughout pregnancy, since deficiency of LPUFA may linked to obstetrical complications. This study aimed to investigate LCPUFA status in severe preeclampsia and preterm birth. A cross sectional study was conducted in 104 pregnant women, which divided into normal pregnancy, severe preeclampsia and preterm birth groups. Serum percentage and concentration of total LCPUFA, omega-3, alpha-linolenic acid (ALA), eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), omega-6, linoleic acid (LA), and arachidonic acid (AA) were measured using gas chromatography/mass spectrometry. Receiver operating characteristic (ROC), bivariate and multivariate analysis were performed. Severe preeclampsia showed the highest concentration of total PUFA and the lowest DHA percentage, with significantly higher Omega-6/Omega-3 ratio (p = 0.004) and lower omega-3 index (p < 0.002) compared to control. Preterm birth showed the least omega-3 concentrations, with significantly low omega-6 derivates (LA (p = 0.014) and AA (p = 0.025)) compared to control. LCPUFA parameters have shown to increase the risk in both conditions, particularly ALA ≤ 53 µmol/L in preeclampsia with OR 5.44, 95%CI 1.16–25.42 and preterm birth with OR 4.68, 95%CI 1.52–14.38. These findings suggest that severe preeclampsia and preterm birth have an imbalance in LCPUFA status. © 2021, The Author(s). |
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unsaturated fatty acid; adult; blood; case control study; cross-sectional study; female; human; Indonesia; male; newborn; nutritional status; pathology; preeclampsia; pregnancy; prematurity; severity of illness index; young adult; Adult; Case-Control Studies; Cross-Sectional Studies; Fatty Acids, Unsaturated; Female; Humans; Indonesia; Infant, Newborn; Male; Nutritional Status; Pre-Eclampsia; Pregnancy; Premature Birth; Severity of Illness Index; Young Adult |
Nature Research |
20452322 |
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34282168 |
Article |
Q1 |
1240 |
3130 |
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65 |
Setiawan E.A., Rianda D., Kadim M., Meilianawati, Susanto F., Kok F.J., Shankar A.H., Agustina R. |
57214103232;57214119630;26644177600;57224214324;57224212671;56506613800;7005442634;57214141404; |
Tenth year reenrollment randomized trial investigating the effects of childhood probiotics and calcium supplementation on height and weight at adolescence |
2021 |
Scientific Reports |
11 |
1 |
11860 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107265110&doi=10.1038%2fs41598-021-88819-y&partnerID=40&md5=ffa4a369e5635d1edafff9d5559b7d3c |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Setiawan, E.A., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Rianda, D., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kadim, M., Department of Pediatric, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Meilianawati, Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Susanto, F., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia; Kok, F.J., Division of Human Nutrition and Health, Wageningen University, Wageningen, Netherlands; Shankar, A.H., Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jl. Salemba Raya No.6, Jakarta, 10430, Indonesia, Human Nutrition Research Center, Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Microbiota and its modification with specific probiotics in early life could provide long term health benefits. Probiotics and calcium strengthen intestinal integrity and may support linear growth. This study investigated the long-term effects of childhood probiotics and calcium supplementation on growth in adolescence. We re-enrolled 238 adolescents aged 11–18 years from 494 children 10-years after 6-months of supplementation with either low-lactose milk fortified with low levels of calcium (LC, ∼50 mg/day, n = 53/124), with regular levels of calcium (RC, ∼440 mg/day, n = 70/126), or with regular calcium + 5 x 108 CFU/day Lactobacillus reuteri DSM 17938 (Reuteri, n = 55/124), or regular calcium + 5 x 108 CFU/day L. casei CRL 431 (Casei, n = 60/120). Changes in height-for-age z-score (HAZ) and body mass index-for-age z-score (BMIZ) were determined from the end of intervention to re-enrollment. General linear models were used to assess the effects on HAZ and BMIZ of group, gender, living area, maternal education, family income, physical activity, diet quality, nutritional status, and gut integrity as determined by urinary lactulose/mannitol ratio (L:M). Adolescent mean age was 15.3 years, mean HAZ was − 1.11, mean BMIZ was − 0.2 and median L:M (n = 155) was 0.23. Changes in HAZ and BMIZ were not significantly different between Casei, Reuteri, LC compared to RC. However, a significant decrease in BMIZ was observed among female adolescents in the Casei compared to RC group (− 0.5 SD, 95% CI − 0.8 to − 0.003, p = 0.048). Childhood probiotic and calcium supplementation may therefore selectively affect female adolescents. Clinical trial registration: This follow-up study has been registered at www.clinicaltrials.gov, Registry name: Rina Agustina, Registration number: NCT04046289, First Registration Date 06/08/19. web link: https://www.clinicaltrials.gov/ct2/show/NCT04046289. © 2021, The Author(s). |
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lactulose; mannitol; probiotic agent; administration and dosage; adolescent; body height; body mass; body weight; calcium intake; controlled study; diet therapy; dietary supplement; double blind procedure; epidemiology; female; follow up; fortified food; health auxiliary; human; Indonesia; Lactobacillus casei; Lactobacillus reuteri; male; nutritional status; randomized controlled trial; risk factor; statistical model; Adolescent; Body Height; Body Mass Index; Body Weight; Calcium, Dietary; Community Health Workers; Dietary Supplements; Double-Blind Method; Female; Follow-Up Studies; Food, Fortified; Humans; Indonesia; Lactobacillus casei; Lactobacillus reuteri; Lactulose; Linear Models; Male; Mannitol; Nutrition Therapy; Nutritional Status; Probiotics; Risk Factors |
Nature Research |
20452322 |
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34088920 |
Article |
Q1 |
1240 |
3130 |
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74 |
Darmadi J., Batubara R.R., Himawan S., Azizah N.N., Audah H.K., Arsianti A., Kurniawaty E., Ismail I.S., Batubara I., Audah K.A. |
57222431230;57220745212;57222422725;57191927056;57222432027;36124567000;57214889313;7103005751;26031903000;15119028200; |
Evaluation of Indonesian mangrove Xylocarpus granatum leaves ethyl acetate extract as potential anticancer drug |
2021 |
Scientific Reports |
11 |
1 |
6080 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102715983&doi=10.1038%2fs41598-021-85383-3&partnerID=40&md5=0ea6644166c67e4defd273cae7f6aa43 |
Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia; Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Darmadi, J., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Batubara, R.R., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Himawan, S., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Azizah, N.N., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia; Audah, H.K., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia; Arsianti, A., Drug Development Research Center, IMERI, University of Indonesia, Jakarta, 10430, Indonesia, Department of Medical Chemistry, University of Indonesia, Jakarta, 10430, Indonesia; Kurniawaty, E., Faculty of Medicine, University of Lampung, Bandar Lampung, 35145, Indonesia; Ismail, I.S., Institute of Bioscience, Universiti Putra Malaysia, Serdang, 43400, Malaysia; Batubara, I., Biopharmaca Tropica Research Center, IPB University, Bogor, 16680, Indonesia, Department of Chemistry, IPB University, Bogor, 16680, Indonesia; Audah, K.A., Department of Biomedical Engineering, Swiss German University, Tangerang, 15143, Indonesia, Directorate of Academic Research and Community Service, Swiss German University, Tangerang, 15143, Indonesia |
Local Xylocarpus granatum leaves were extracted by ethyl acetate solvent and characterized by TLC fingerprinting and 2D 1H NMR spectroscopy to contain phenolic compounds as well as several organic and amino acids as metabolic byproducts, such as succinic acid and acetic acid. Traces of flavonoids and other non-categorized phenolic compounds exhibited intermediate antioxidant activity (antioxidant IC50 84.93 ppm) as well as anticancer activity against HeLa, T47D, and HT-29 cell lines; which the latter being most effective against HT-29 with Fraction 5 contained the strongest activity (anticancer IC50 23.12 ppm). Extracts also behaved as a natural growth factor and nonlethal towards brine shrimps as well as human adipose-derived stem cell hADSC due to antioxidative properties. A stability test was performed to examine how storage conditions factored in bioactivity and phytochemical structure. Extracts were compared with several studies about X. granatum leaves extracts to evaluate how ethnogeography and ecosystem factored on biologically active compounds. Further research on anticancer or antioxidant mechanism on cancer cells is needed to determine whether the extract is suitable as a candidate for an anticancer drug. © 2021, The Author(s). |
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acetic acid; antineoplastic agent; plant extract; adipose tissue; animal; Artemia; chemistry; drug screening; HeLa cell line; HT-29 cell line; human; MCF-7 cell line; Meliaceae; metabolism; neoplasm; plant leaf; stem cell; Acetates; Adipose Tissue; Animals; Antineoplastic Agents, Phytogenic; Artemia; Drug Screening Assays, Antitumor; HeLa Cells; HT29 Cells; Humans; MCF-7 Cells; Meliaceae; Neoplasms; Plant Extracts; Plant Leaves; Stem Cells |
Nature Research |
20452322 |
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33727582 |
Article |
Q1 |
1240 |
3130 |
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No records
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418 |
Ariyanto I.A., Lee S., Estiasari R., Edmands J., Bela B., Soebandrio A., Price P. |
57193538110;56272877300;55240204000;57207355582;24723637900;8602893200;57201814264; |
Understanding the effects of CMV on γδ T-cell populations in HIV patients starting antiretroviral therapy |
2021 |
Clinical Immunology |
226 |
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108696 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103343868&doi=10.1016%2fj.clim.2021.108696&partnerID=40&md5=537b6ce49573252250340726edc3d07d |
Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia; School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Ariyanto, I.A., Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lee, S., Department of Microbiology, Pathwest Laboratory Medicine, Perth, Australia, School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Estiasari, R., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Edmands, J., School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia; Bela, B., Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soebandrio, A., Eijkman Institute for Molecular Biology, Jakarta, Indonesia; Price, P., Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, School of Pharmacy & Biomedical Science, Curtin University, Perth, Australia |
Cytomegalovirus (CMV) affects γδ T-cell profiles in healthy individuals and transplant recipients, but the effects of HIV and CMV have not been distinguished in HIV patients. CMV-seropositive Indonesian HIV patients (n = 40) were studied before ART and after six months, alongside healthy controls (n = 20). 50% of patients started ART with detectable CMV DNA. Proportions of Vδ2− γδ T-cells were high in patients and declined on ART, whilst proportions of Vδ2+ γδ T-cells were uniformly low, and correlated inversely with levels of CMV DNA and CMV-reactive antibody. Residual Vδ2+ cells were enriched for markers of terminal differentiation, but this did not associate with CMV metrics. Patients with CMV DNA at baseline showed a direct correlation between CMV reactive-antibody and CD8+ γδ T-cells. Our data are consistent with a role for CMV in the depletion of Vδ2+ γδ T-cells in HIV patients beginning ART, with no consistent evidence of a role for CMV in γδ T-cell activation or differentiation. © 2021 |
Antiretroviral therapy; CMV; HIV; γδ T-cells |
adult; antiretroviral therapy; article; cell population; clinical article; controlled study; Cytomegalovirus; female; gamma delta T lymphocyte; human; human cell; Human immunodeficiency virus infected patient; male; nonhuman; T lymphocyte activation; adolescent; Cytomegalovirus; cytomegalovirus infection; graft recipient; Human immunodeficiency virus infection; immunology; intraepithelial lymphocyte; lymphocyte activation; middle aged; young adult; antiretrovirus agent; lymphocyte antigen receptor; virus antibody; Adolescent; Adult; Anti-Retroviral Agents; Antibodies, Viral; Cytomegalovirus; Cytomegalovirus Infections; Female; HIV Infections; Humans; Intraepithelial Lymphocytes; Lymphocyte Activation; Male; Middle Aged; Receptors, Antigen, T-Cell, gamma-delta; Transplant Recipients; Young |
Academic Press Inc. |
15216616 |
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33621667 |
Article |
Q2 |
1236 |
3138 |
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No records
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47 |
Craddock N., Garbett K.M., Haywood S., Nasution K., White P., Saraswati L.A., Rizkiah C., Medise B.E., Diedrichs P.C. |
57204036842;56901034200;57339654700;57339654800;55730025700;55842541900;57339370700;57194679894;6504448191; |
‘Dove Confident Me Indonesia: Single Session’: study protocol for a randomised controlled trial to evaluate a school-based body image intervention among Indonesian adolescents |
2021 |
BMC Public Health |
21 |
1 |
2102 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119148188&doi=10.1186%2fs12889-021-11770-0&partnerID=40&md5=081ebeb058ffd74b7c5312132c820642 |
Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; University of Hawaiʻi at Mānoa, Honolulu, United States; Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia |
Craddock, N., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Garbett, K.M., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Haywood, S., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Nasution, K., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; White, P., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom; Saraswati, L.A., University of Hawaiʻi at Mānoa, Honolulu, United States; Rizkiah, C., Lazuardi Al Falah Depok Junior High School Indonesia, Kota Depok, Indonesia; Medise, B.E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Diedrichs, P.C., Centre for Appearance Research, University of the West of England, Coldharbour Lane, Bristol, BS16 1QY, United Kingdom |
Background: Due to the prevalence and associated adverse health consequences of negative body image among adolescents globally, there is a need to develop acceptable, effective, and scalable interventions. School-based body image interventions delivered by trained teachers show promise in reducing negative body image in adolescents. However, there is currently a lack of evidenced-based body image interventions for use in low- and middle-income countries (LMICs). This paper outlines a protocol for the development and evaluation of Dove Confident Me Indonesia: Single Session, a single-session, teacher-led body image intervention for Indonesian adolescents. Method: The effectiveness of the intervention will be evaluated using a cluster randomised controlled trial design. Due to the COVID-19 pandemic, the trial will be conducted online. Trained teachers or school guidance counsellors will deliver the intervention. Self-report questionnaires will be collected at three time points: baseline, post-intervention, and two-month follow-up. The primary outcome is body esteem. Secondary outcomes are internalisation of appearance ideals, mood, engagement in life activities, tendency to engage in appearance comparisons, and skin shade satisfaction. A minimum of 1000 participants will provide 95% power to detect small-to-medium intervention effects. To account for attrition and potential internet issues, the sample will comprise of 2000 Indonesian adolescents in grades 7–9, attending state junior high schools in Surabaya, East Java. Quantitative and qualitative data on acceptability of the intervention will also be collected from teachers and students. Additionally, fidelity of lesson implementation will be assessed. This project received ethical approval from the Universitas Indonesia and the University of the West of England. The intervention will be disseminated in junior high schools throughout Indonesia via UNICEF’s Life Skills Education (LSE) programme, which will be freely available for teachers to download. Discussion: This paper presents Dove Confident Me Indonesia: Single Session, a culturally adapted school-based intervention designed to improve Indonesian adolescents’ body image. It details the plan for evaluation, highlighting the strengths and limitations of the proposed study design. It will be informative for others aiming to adapt evidence-based school curricula to promote well-being among adolescents in LMICs. Trial registration: NCT04665557. Registered 11th December 2020. © 2021, The Author(s). |
Adolescent mental health; Body image; Indonesia; Life skills education; Low- and middle-income countries; Randomised controlled trial; School-based intervention; Single-session intervention; Southeast Asia; Study protocol |
adolescent; body image; human; Indonesia; pandemic; randomized controlled trial (topic); school; school health service; Adolescent; Body Image; COVID-19; Humans; Indonesia; Pandemics; Randomized Controlled Trials as Topic; SARS-CoV-2; School Health Services; Schools |
BioMed Central Ltd |
14712458 |
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34784916 |
Article |
Q1 |
1230 |
3166 |
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55 |
Mansyur M., Sagitasari R., Wangge G., Sulistomo A.B., Kekalih A. |
37085506800;57290722900;36497482500;57024018500;55633562200; |
Long working hours, poor sleep quality, and work-family conflict: determinant factors of fatigue among Indonesian tugboat crewmembers |
2021 |
BMC Public Health |
21 |
1 |
1832 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116761265&doi=10.1186%2fs12889-021-11883-6&partnerID=40&md5=4563534bbfe5b850aae54955a11550c5 |
Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Mansyur, M., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sagitasari, R., Occupational Medicine Post Graduate Study Program, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wangge, G., South East Asian Ministers Education Organization, Regional Center for Food and Nutrition/SEAMEO-RECFON, Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Sulistomo, A.B., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kekalih, A., Occupational Medicine Division, Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Tugboat crewmembers are susceptible to fatigue during their 24-h work shifts, despite the availability of rest time. The fatigue experienced by seafarers contributes to marine accidents and metabolic and cardiovascular diseases, which have long-term effects. This study aimed to analyse the association between working hours and fatigue and other possibly related factors in tugboat crewmembers. Method: This comparative cross-sectional study included 127 tugboat crew members from 15 randomly chosen tugboats in Samarinda Harbor, Indonesia. Their fatigue levels while at work were measured using a reaction timer and standardised questionnaire. Personal and occupational data of crewmembers, including age, marital status, rating (job ranking), duration on board, length of seafaring experience, watch system, smoking status, coffee and alcohol consumption, and working hours, were collected. Moreover, sleep quality and stress levels related to work-family conflict were measured and analysed using the Pittsburgh Sleep Quality Index (PSQI) and Work-Family Conflict Scale (WCFS), respectively. Results: The study found that 40.2% of the subjects were classified as having fatigue. The determinant factors were long working hours (> 72 h/week), poor sleep quality, and work-family conflict [adj. OR = 13.32; 95%-CI (4.78–31.23)] and p < 0.001, [adj. OR = 4.49 (1.39–14.52)] and p = 0.012, [adj. OR = 2.87 (1.12–7.33)] and p = 0.028, respectively. However, personal and occupational factors, including age, marital status, duration on board, length of seafaring experience, smoking status, and coffee and alcohol consumption, were not significantly associated with crewmember fatigue. Conclusion: The incidence of fatigue among Indonesian tugboat crewmembers operating on the Mahakam River was considerably high. Working hours, sleep quality, and work-family conflict were strongly associated with fatigue in tugboat crewmembers; therefore, the working hours of tugboat crewmembers need to be improved. Crewmember lifestyle variables need to be studied further. © 2021, The Author(s). |
Fatigue; Seafarer; Sleep quality; Tugboat crewmembers; Work-family conflict; Working hours |
cross-sectional study; family conflict; fatigue; human; Indonesia; sleep; work schedule; Cross-Sectional Studies; Family Conflict; Fatigue; Humans; Indonesia; Sleep; Work Schedule Tolerance |
BioMed Central Ltd |
14712458 |
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34627227 |
Article |
Q1 |
1230 |
3166 |
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67 |
Liem J.F., Mansyur M., Soemarko D.S., Kekalih A., Subekti I., Suyatna F.D., Suryandari D.A., Malik S.G., Pangaribuan B. |
57224169741;37085506800;57192889490;55633562200;24336854300;56039633100;6505763338;7402973374;54785015100; |
Cumulative exposure characteristics of vegetable farmers exposed to Chlorpyrifos in Central Java – Indonesia; a cross-sectional study |
2021 |
BMC Public Health |
21 |
1 |
1066 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107125504&doi=10.1186%2fs12889-021-11161-5&partnerID=40&md5=9fb7a1aa16134c6ee9e3e23e6280115f |
Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Liem, J.F., Doctoral Program, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia, Department of Occupational Health and Safety, Faculty of Medicine and Health Science Universitas Kristen Krida Wacana, Jakarta, 11510, Indonesia; Mansyur, M., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Soemarko, D.S., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Kekalih, A., Community Medicine Department, Faculty of Medicine Universitas Indonesia, Jakarta, 10320, Indonesia; Subekti, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suyatna, F.D., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Suryandari, D.A., Department of Biology, Faculty of Medicine Universitas Indonesia, Jakarta, 10430, Indonesia; Malik, S.G., Eijkman Institute for Molecular Biology, National Research and Innovation Agency, Jalan Diponegoro No. 69, Kota Jakarta Pusat, Jakarta, Indonesia; Pangaribuan, B., Prodia Occupational Health Institute International, Jakarta, 10430, Indonesia |
Background: Agriculture is a major economic sector in Indonesia. Chemical pesticides are widely being used in agriculture for controlling pest. There is a growing concern that pesticide exposure, particularly chlorpyrifos (CPF) exposure, combined with other occupational characteristics that determine the level of exposure, can lead to further health impacts for farmers. Our objective was to evaluate the cumulative exposure characteristics among farmers exposed to CPF by using a validated algorithm. Methods: We conducted a cross-sectional study of 152 vegetable farmers aged 18–65 who actively used CPF for at least 1 year in Central Java, Indonesia. Subject characteristics were obtained using a structured interviewer-administered questionnaire, addressed for sociodemographic and work-related characteristics. The cumulative exposure level (CEL) was estimated as a function of the intensity level of pesticide exposure (IL), lifetime years of pesticide use and the number of days spraying per year. CEL was subsequently classified into two groups, high and low exposure groups. The difference in characteristics of the study population was measured using Chi-square, independent-t or Mann-Whitney test. Association between CEL and its characteristics variables were performed by multiple linear regression. Results: Seventy-one subjects (46.7%) were classified as the high exposure group. The use of multiple pesticide mixtures was common among our study population, with 94% of them using 2 or more pesticides. 73% reported direct contact with concentrated pesticides product, and over 80% reported being splashed or spilt during preparation or spraying activity. However, we found that the proportion of proper personal protective equipment (PPE) use in our subjects was low. Higher volume of mixture applied (p < 0.001) and broader acres of land (p = 0.001) were associated with higher cumulative exposure level, while using long-sleeved clothes and long pants (p < 0.05) during pesticide spraying were associated with lower cumulative exposure after adjusted for age and gender. Conclusions: These findings indicate an inadequate knowledge of using pesticides properly. Thus, we recommend comprehensive training on pesticide usage and encourage proper PPE to reduce the exposure level. © 2021, The Author(s). |
Exposure assessment; Exposure reduction; Occupational characteristics; Pesticide cumulative exposure; Work practices |
chlorpyrifos; pesticide; adverse event; agricultural worker; agriculture; cross-sectional study; epidemiology; human; Indonesia; occupational exposure; vegetable; Agriculture; Chlorpyrifos; Cross-Sectional Studies; Farmers; Humans; Indonesia; Occupational Exposure; Pesticides; Vegetables |
BioMed Central Ltd |
14712458 |
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34090393 |
Article |
Q1 |
1230 |
3166 |
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