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Gde Putra Semara Jaya A.A., Tantri A.R., Heriwardito A., Mansjoer A. |
57352086800;57188933853;57195378515;24335647800; |
Single-centre, double-blind, randomised, parallel-group, superiority study to evaluate the effectiveness of general anaesthesia and ultrasound-guided transversus thoracis muscle plane block combination in adult cardiac surgery for reducing the surgical stress response: Clinical trial protocol |
2021 |
BMJ Open |
11 |
11 |
e051008 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119887424&doi=10.1136%2fbmjopen-2021-051008&partnerID=40&md5=0586982ad2f206c40847d8ac96911ca0 |
Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Indonesia |
Gde Putra Semara Jaya, A.A., Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Tantri, A.R., Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Heriwardito, A., Department of Anesthesiology and Intensive Care, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta Pusat, Indonesia; Mansjoer, A., Division of Cardiology, Department of Internal Medicine, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine Universitas Indonesia, Jakarta Pusat, Indonesia |
Introduction Adult open-heart surgery is a major surgery that causes surgical stress response and activation of the immune system, contributing further to postoperative complications. Transversus thoracis muscle plane block (TTPB) may potentially benefit in reducing the surgical stress response. This study aims to know the effectiveness of preoperative TTPB in adult open-heart surgery for reducing the surgical stress response. Methods and analysis This study is a prospective, double-blind, randomised control trial comparing the combination of general anaesthesia and TTPB versus general anaesthesia only in adult open-heart surgery. Forty-two eligible subjects will be randomly assigned to the TTPB group or control group. The primary outcomes are the difference between the two groups in the means of postoperative cortisol and interleukin-6 plasma levels at 24 hours and 48 hours after cardiac intensive care unit admission. The secondary outcomes are the difference between the two groups in the means of total 24-hour postoperative morphine consumption and time of first postoperative patient-controlled analgesia (PCA) dose. Ethics and dissemination The study protocol and informed consent forms have been reviewed and approved by the Ethics Committee of Faculty of Medicine Universitas Indonesia/Dr. Cipto Mangunkusumo Hospital. The result will be released to the medical community through presentation and publication in peer-reviewed journals. Trial registration number NCT04544254. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
adult anaesthesia; anaesthesia in cardiology; cardiothoracic surgery; pain management |
bupivacaine; fentanyl; hydrocortisone; interleukin 6; midazolam; morphine; paracetamol; rocuronium; sevoflurane; narcotic analgesic agent; adult; aged; Article; clinical article; comparative effectiveness; controlled study; coronary care unit; endotracheal intubation; enzyme linked immunosorbent assay; female; general anesthesia; heart surgery; hospital admission; human; male; nerve block; open heart surgery; oxygen therapy; patient controlled analgesia; postoperative period; protein blood level; randomized controlled trial (topic); surgical stress; transversus thoracis muscle plane block; double blind procedure; general anesthesia; interventional ultrasonography; muscle; postoperative pain; prospective study; Adult; Analgesics, Opioid; Anesthesia, General; Cardiac Surgical Procedures; Dou |
BMJ Publishing Group |
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34764171 |
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170 |
Nainggolan G., Soemarko D., Siregar P., Sutranto A.L., Bardosono S., Prijanti A.R., Aulia D. |
23498775400;57192889490;57205715021;57286411000;21933841000;57190863386;6602865986; |
Diagnostic role of urine specific gravity to detect kidney impairment on heat-exposed workers in a shoe factory in Indonesia: A cross-sectional study |
2021 |
BMJ Open |
11 |
9 |
e047328 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85116507527&doi=10.1136%2fbmjopen-2020-047328&partnerID=40&md5=b097275ffe1ee980cb242c3e4759fa0e |
Division of Nephrology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Division of Occupational Medicine, Department of Community Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Nainggolan, G., Division of Nephrology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Soemarko, D., Division of Occupational Medicine, Department of Community Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Siregar, P., Division of Nephrology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Sutranto, A.L., Division of Nephrology, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Prijanti, A.R., Department of Biochemistry and Molecular Biology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aulia, D., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Objectives Globally, there are increasing cases of chronic kidney disease of unknown origin among heat-exposed workers. We aimed to see the kidney damages of indoor heat-exposed workers and whether urine specific gravity can predict any kidney damages. Design A cross-sectional study. Setting A shoe-making factory in West Java, Indonesia. Participants 119 subjects were included. Minimum total sample size was 62. Subjects were indoor heat-exposed workers who were exposed to occupational wet-bulb globe temperature (WBGT) of 28°C-30°C for 8 hours daily with 1 hour break, 5 days a week. The inclusion criterion was healthy subjects according to the result from annual medical check-up in 2019. The exclusion criteria were subjects who were taking vitamins and/or supplements that might cause disturbance in urine specific gravity and/or hydration status, pregnant and fasting. Primary and secondary outcome measures Area under the curve (AUC), sensitivity and specificity of urine specific gravity for the detection of urinary nephrin and urinary kidney injury molecule-1 (KIM-1) were analysed. Estimated glomerular filtration rate (eGFR) and quantitative albuminuria were also measured. Results WBGT in the work area of the subject was 28°C-30°C. There were 15 (12.6%) subjects who had eGFR <90 mL/min, but ≥60 mL/min. High serum vasopressin levels were found in 79 subjects with a mean of 6.54 (95% CI 5.94 to 7.14) ng/mL. Most subjects had nephrinuria (87.4%) with preserved renal function (87.4%). Several subjects had elevated urinary KIM-1 (10.9%) and albuminuria (7.6%). AUC of urine specific gravity for increased urinary nephrin was 81.7% (95% CI 68.8% to 94.6%) and statistically significant (p<0.001). Cut-off value of ≥1.018 for urine specific gravity has sensitivity of 71.2% and specificity of 80% for detecting elevation of urinary nephrin levels. Conclusion Urine specific gravity with a cut-off value of ≥1.018 could be used to detect nephrinuria among heat-exposed workers. © |
clinical chemistry; nephrology; occupational & industrial medicine |
albumin; hepatitis A virus cellular receptor 1; nephrin; vasopressin; adult; albumin blood level; albuminuria; Article; cross-sectional study; estimated glomerular filtration rate; factory worker; fasting; female; human; hydration status; Indonesia; kidney function; kidney injury; major clinical study; medical examination; nephrinuria; occupational exposure; pregnancy; proteinuria; relative density; sensitivity and specificity; shoe industry; thermal exposure; urine; urine level; urine sampling; vasopressin blood level; wet bulb globe temperature; wet bulb temperature; adverse event; chronic kidney failure; heat; heat injury; kidney; occupational exposure; relative density; Cross-Sectional Studies; Heat Stress Disorders; Hot Temperature; Humans; Indonesia; Kidney; Occupational Exposure; Re |
BMJ Publishing Group |
20446055 |
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34588241 |
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174 |
Ambari A.M., Setianto B., Santoso A., Radi B., Dwiputra B., Susilowati E., Tulrahmi F., Wind A., Cramer M.J.M., Doevendans P. |
57189576921;57192893995;36905206100;6603494019;57195383994;57200092387;57210209635;57265425700;7102305152;7004918581; |
Randomised controlled trial into the role of ramipril in fibrosis reduction in rheumatic heart disease: The RamiRHeD trial protocol |
2021 |
BMJ Open |
11 |
9 |
e048016 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115217044&doi=10.1136%2fbmjopen-2020-048016&partnerID=40&md5=37438fc881ccc33516a8361ba43e3971 |
Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia; Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, West Jakarta Jakarta, Indonesia; Research Assistant of Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia; Department of Cardiology, University Medical Centre Utrecht, Utrecht, Netherlands; Central Military Hospital, Netherlands Heart Institute, Utrecht, Netherlands |
Ambari, A.M., Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, West Jakarta Jakarta, Indonesia; Setianto, B., Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, West Jakarta Jakarta, Indonesia; Santoso, A., Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, West Jakarta Jakarta, Indonesia; Radi, B., Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, West Jakarta Jakarta, Indonesia; Dwiputra, B., Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia, Department of Cardiology and Vascular Medicine, Faculty of Medicine, Universitas Indonesia, West Jakarta Jakarta, Indonesia; Susilowati, E., Research Assistant of Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia; Tulrahmi, F., Research Assistant of Department of Cardiovascular Prevention and Rehabilitation, National Cardiovascular Center Harapan Kita, West Jakarta Jakarta, Indonesia; Wind, A., Department of Cardiology, University Medical Centre Utrecht, Utrecht, Netherlands; Cramer, M.J.M., Department of Cardiology, University Medical Centre Utrecht, Utrecht, Netherlands; Doevendans, P., Department of Cardiology, University Medical Centre Utrecht, Utrecht, Netherlands, Central Military Hospital, Netherlands Heart Institute, Utrecht, Netherlands |
Introduction Rheumatic heart disease (RHD) is a major burden in developing countries and accounts for 80% of all people living with the disease, where it causes most cardiovascular morbidity and mortality in children and young adults. Chronic inflammation and fibrosis of heart valve tissue due to chronic inflammation in RHD will cause calcification and thickening of the impacted heart valves, especially the mitral valve. This fibrogenesis is enhanced by the production of angiotensin II by increased transforming growth factor β expression and later by the binding of interleukin-33, which is known to have antihypertrophic and antifibrotic effects, to soluble sST2. sST2 binding to this non-natural ligand worsens fibrosis. Therefore, we hypothesise that ACE inhibitors (ACEIs) would improve rheumatic mitral valve stenosis. Methods and analysis This is a single-centre, double-blind, placebo-controlled, randomised clinical trial with a pre-post test design. Patients with rheumatic mitral stenosis and valve dysfunction will be planned for cardiac valve replacement operation and will be given ramipril 5 mg or placebo for a minimum of 12 weeks before the surgery. The expression of ST2 in the mitral valve is considered to be representative of cardiac fibrosis. Mitral valve tissue will be stained by immunohistochemistry to ST2. Plasma ST2 will be measured by ELISA. This study is conducted in the Department of Cardiology and Vascular Medicine, Universitas Indonesia, National Cardiac Center Harapan Kita Hospital, Jakarta, Indonesia, starting on 27 June 2019. Ethics and dissemination The performance and dissemination of this study were approved by the ethics committee of National Cardiovascular Center Harapan Kita with ethical code LB.02.01/VII/286/KEP.009/2018. Trial registration number NCT03991910. © 2021 BMJ Publishing Group. All rights reserved. |
cardiology; cardiothoracic surgery; valvular heart disease |
interleukin 1 receptor like 1 protein; placebo; ramipril; ramipril; adult; Article; clinical trial protocol; controlled study; double blind procedure; enzyme linked immunosorbent assay; female; heart muscle fibrosis; human; human tissue; immunohistochemistry; Indonesia; male; mitral valve stenosis; pretest posttest design; protein blood level; protein expression; randomized controlled trial; rheumatic heart disease; child; fibrosis; heart surgery; mitral valve stenosis; randomized controlled trial (topic); young adult; Cardiac Surgical Procedures; Child; Fibrosis; Humans; Mitral Valve Stenosis; Ramipril; Randomized Controlled Trials as Topic; Rheumatic Heart Disease; Young Adult |
BMJ Publishing Group |
20446055 |
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34518254 |
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178 |
Yamada C., Siste K., Hanafi E., Ophinni Y., Beatrice E., Rafelia V., Alison P., Limawan A., Shinozaki T., Matsumoto T., Sakamoto R. |
57222342981;55644113100;56737010600;57198779809;57215769595;57253865100;57254672000;57202712511;55129157400;55624483618;23992806400; |
Relapse prevention group therapy via video-conferencing for substance use disorder: Protocol for a multicentre randomised controlled trial in Indonesia |
2021 |
BMJ Open |
11 |
9 |
e050259 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85114681155&doi=10.1136%2fbmjopen-2021-050259&partnerID=40&md5=f40f8485b5314829dcd4365ab57bf817 |
Department of Environmental Coexistence, Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan; Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ragon Institute of Mgh, Mit and Harvard, Cambridge, MA, United States; Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan; Department of Drug Dependence Research, National Center of Neurology and Psychiatry, Tokyo, Japan |
Yamada, C., Department of Environmental Coexistence, Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan; Siste, K., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hanafi, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Ophinni, Y., Ragon Institute of Mgh, Mit and Harvard, Cambridge, MA, United States; Beatrice, E., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Rafelia, V., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alison, P., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Limawan, A., Department of Psychiatry, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Shinozaki, T., Department of Information and Computer Technology, Faculty of Engineering, Tokyo University of Science, Tokyo, Japan; Matsumoto, T., Department of Drug Dependence Research, National Center of Neurology and Psychiatry, Tokyo, Japan; Sakamoto, R., Department of Environmental Coexistence, Center for Southeast Asian Studies, Kyoto University, Kyoto, Japan |
Background Substance use disorder (SUD) is a leading contributor to the global burden of disease. In Indonesia, the availability of formal treatment for SUD falls short of the targeted coverage. A standardised therapeutic option for SUD with potential for widespread implementation is required, yet evidence-based data in the country are scarce. In this study, we developed a cognitive behavioural therapy (CBT)-based group telemedicine model and will investigate effectiveness and implementability in a multicentre randomised controlled trial. Methods A total of 220 participants will be recruited from the social networks of eight sites in Indonesia: three hospitals, two primary healthcare centres and three rehabilitation centres. The intervention arm will participate in a relapse prevention programme called the Indonesia Drug Addiction Relapse Prevention Programme (Indo-DARPP), a newly developed 12-week module based on CBT and motivational interviewing constructed in the Indonesian context. The programme will be delivered by a healthcare provider and a peer counsellor in a group therapy setting via video-conferencing, as a supplement to participants' usual treatments. The control arm will continue treatment as usual. The primary outcome will be the percentage increase in days of abstinence from the primarily used substance in the past 28 days. Secondary outcomes will include addiction severity, quality of life, motivation to change, psychiatric symptoms, cognitive function, coping, and internalised stigma. Assessments will be performed at baseline (week 0), post-treatment (week 13), and 3 and 12 months post-treatment completion (weeks 24 and 60). Retention, participant satisfaction, and cost-effectiveness will be assessed as the implementation outcomes. Ethics and dissemination The study protocol was reviewed and approved by the Ethics Committees of Universitas Indonesia and Kyoto University. The results will be disseminated via academic journals and international conferences. Depending on trial outcomes, the treatment programme will be advocated for adoption as a formal healthcare-based approach for SUD. Trial registration number UMIN000042186. © 2021 BMJ Publishing Group. All rights reserved. |
clinical trials; psychiatry; substance misuse; telemedicine |
Article; benzodiazepine dependence; cannabis addiction; cognition; cognitive behavioral therapy; controlled study; coping behavior; cost effectiveness analysis; counselor; disease severity; drug dependence; drug withdrawal; group therapy; health care personnel; heroin dependence; human; Indonesia; major clinical study; mental disease; methamphetamine dependence; motivational interviewing; multicenter study; opiate addiction; outcome assessment; patient satisfaction; preventive health service; program effectiveness; quality of life; randomized controlled trial; relapse; stigma; teleconference; videoconferencing; cost benefit analysis; multicenter study (topic); randomized controlled trial (topic); secondary prevention; Cost-Benefit Analysis; Humans; Indonesia; Multicenter Studies as Topic; |
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Agustina R., Syam A.F., Wirawan F., Widyahening I.S., Rahyussalim A.J., Yusra Y., Rianda D., Burhan E., Salama N., Daulay R., Halim A.R.V., Shankar A.H. |
57214141404;8443384400;57205313463;54893154400;55212166100;57220998367;57214119630;36058554600;57219411020;57226811488;57226806443;7005442634; |
Integration of symptomatic, demographical and diet-related comorbidities data with SARS-CoV-2 antibody rapid diagnostic tests during epidemiological surveillance: A cross-sectional study in Jakarta, Indonesia |
2021 |
BMJ Open |
11 |
8 |
e047763 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112745267&doi=10.1136%2fbmjopen-2020-047763&partnerID=40&md5=1e972251c248b0cfbea89e8c34d44b24 |
Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Clinical Epidemiology and Evidence-Based Medicine Unit, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom; Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Agustina, R., Department of Nutrition, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia, Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Syam, A.F., Department of Internal Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Wirawan, F., Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Widyahening, I.S., Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Clinical Epidemiology and Evidence-Based Medicine Unit, Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Rahyussalim, A.J., Department of Orthopedic and Traumatology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Yusra, Y., Department of Clinical Pathology, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Rianda, D., Human Nutrition Research Center - Indonesian Medical Education and Research Institute (HNRC-IMERI), Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia - Dr. Cipto Mangunkusumo General Hospital, Jakarta, Indonesia; Salama, N., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Daulay, R., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Halim, A.R.V., Health Office, Government of DKI Jakarta Province, Jakarta, Indonesia; Shankar, A.H., Centre for Tropical Medicine and Global Health, Nuffield Department of Medicine, University of Oxford, Oxford, United Kingdom, Eijkman-Oxford Clinical Research Unit, Eijkman Institute for Molecular Biology, Jakarta, Indonesia |
Affordable options for COVID-19 epidemiological surveillance are needed. Virus detection by reverse transcription-PCR (RT-PCR) is sensitive but costly, and antigen-based rapid diagnostic tests (RDTs) are cheap but with reduced sensitivity; both detect current infection but not exposure. RDT-IgM/IgG antibodies to SARS-CoV-2 detect exposure but have poor sensitivity for current infection. We investigated if the integration of symptomatic, demographical and diet-related comorbidities data with antibody RDTs improves their potential to assess infection rates in addition to exposure, thereby broadening their utility for surveillance. We conducted a cross-sectional study using data from community surveillance for SARS-CoV-2. Health workers collected nasopharyngeal swabs for RT-PCR and RDT antigen assessments and venous blood for RDT-IgM/IgG from symptomatic and asymptomatic persons. Data on age, gender, contact history, symptoms (ie, fever, cough, runny nose, sore throat, headache, dyspnoea and diarrhoea), diet-related comorbidities (ie, diabetes and hypertension) and chest radiology were collected. High-risk communities in Jakarta, Indonesia, in May 2020. 343 community members’ data were included. RDT-IgM/IgG sensitivity, specificity and predictive values and area under receiver operating characteristic curve for RT-PCR positivity using RDT results alone and in combination with other predictors, including symptom components derived from principal component analysis. There were 24 PCR-confirmed infections. RDT-IgM/IgG-positive tests were associated with infection (OR 10.8, 95% CI 4.43 to 26.4, p<0.001) with an area under the curve (AUC) of 0.708% and 50% sensitivity, 91.5% specificity, 30.8% positive predictive value (PPV) and 96.1% negative predictive value (NPV). RDT results combined with age, gender, contact history, symptoms and comorbidities increased the AUC to 0.787 and yielded 62.5% sensitivity, 87.0% specificity, 26.6% PPV and 96.9% NPV. SARS-CoV-2 RDT-IgM/IgG results integrated with other predictors may be an affordable tool for epidemiological surveillance for population-based COVID-19 exposure and current infection, especially in groups with outbreaks or high transmission. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
COVID-19; epidemiology; public health |
immunoglobulin G; immunoglobulin M; SARS-CoV-2 antibody; virus antibody; adolescent; adult; aged; area under the curve; Article; child; community; comorbidity; coronavirus disease 2019; coughing; cross-sectional study; demography; diagnostic test; diagnostic test accuracy study; diet; female; health care personnel; human; Indonesia; major clinical study; male; nasopharyngeal swab; predictive value; receiver operating characteristic; reverse transcription polymerase chain reaction; sensitivity and specificity; sore throat; thorax radiography; diagnostic test; diet; epidemiology; Antibodies, Viral; COVID-19; Cross-Sectional Studies; Diagnostic Tests, Routine; Diet; Humans; Indonesia; SARS-CoV-2; Sensitivity and Specificity |
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Wente-Schulz S., Aksenova M., Awan A., Ambarsari C.G., Becherucci F., Emma F., Fila M., Francisco T., Gokce I., Gülhan B., Hansen M., Jahnukainen T., Kallash M., Kamperis K., Mason S., Mastrangelo A., Mencarelli F., Niwinska-Faryna B., Riordan M., Rus R.R., Saygili S., Serdaroglu E., Taner S., Topaloglu R., Vidal E., Woroniecki R., Yel S., Zieg J., Pape L., Boyer O., Buder K., Bulut Ä°.K., Cornelissen E.A.M., del Mar Espino Hernández M., Hooman N., Kemper M., Maquet J., Santos F., Walden U., The international TIN study group |
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Aetiology, course and treatment of acute tubulointerstitial nephritis in paediatric patients: A cross-sectional web-based survey |
2021 |
BMJ Open |
11 |
5 |
e047059 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107244372&doi=10.1136%2fbmjopen-2020-047059&partnerID=40&md5=8b9d8549b7d6c5d3a71a823dffc235d5 |
Department of Pediatric Nephrology, MHH, Hannover, Germany; Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Department of Pediatrics II, University Hospital Essen, Essen, Germany; Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Ege University Faculty of Medicine, Izmir, Turkey; Radboud University Medical Center, Nijmegen, Netherlands; Hospital Universitario 12 de Octubre, Madrid, Spain; Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Asklepios Medical School, Hamburg, Germany; CHC Liège, Belgium; Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Universitätsklinikum Kinderklinik Augsburg, Germany |
Wente-Schulz, S., Department of Pediatric Nephrology, MHH, Hannover, Germany; Aksenova, M., Department of Pediatric Nephrology, Veltischev Research and Clinical Institute for Pediatrics, The Pirogov Russian National Research Medical University, Moskva, Russian Federation; Awan, A., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Ambarsari, C.G., Department of Pediatric Nephrology, Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Central Jakarta, Indonesia; Becherucci, F., Department of Pediatric Nephrology, Meyer Children's Hospital, Florence, Italy; Emma, F., Department of Pediatric Nephrology, Bambino Gesù Children's Hospital, Roma, Italy; Fila, M., Department of Pediatric Nephrology, Montpellier University, Arnaud de Villeneuve Hospital, Montpellier, France; Francisco, T., Department of Pediatric Nephrology, Dona Estefânia Hospital, Lisboa, Portugal; Gokce, I., Department of Pediatric Nephrology, Faculty of Medicine, Marmara University, Istanbul, Turkey; Gülhan, B., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Hansen, M., KfH Centre of Pediatric Nephrology, Clementine Kinderhospital, Frankfurt am Main, Germany; Jahnukainen, T., Department of Pediatric Nephrology and Transplantation, New Children's Hospital, Helsinki University Hospital, Helsinki, Finland; Kallash, M., Department of Pediatric Nephrology, Nationwide Children's Hospital, Columbus, OH, United States; Kamperis, K., Department of Pediatric Nephrology, Aarhus University Hospital, Aarhus, Denmark; Mason, S., Department of Pediatric Nephrology, Connecticut Children's Medical Center, Hartford, CT, United States; Mastrangelo, A., Department of Pediatric Nephrology, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy; Mencarelli, F., Department of Pediatric Nephrology, Azienda Ospedaliero-Universitaria di Bologna, Ospedale S. Orsola-Malpighi, Bologna, Italy; Niwinska-Faryna, B., Department of Pediatric Nephrology, Karolinska University Hospital, Stockholm, Sweden; Riordan, M., Department of Pediatric Nephrology, Temple Street Children's University Hospital, Dublin, Ireland; Rus, R.R., Department of Pediatric Nephrology, University Children's Hospital, Ljubljana, Slovenia; Saygili, S., Department of Pediatric Nephrology, Faculty of Medicine, Istanbul University-Cerrahpasa, Istanbul, Turkey; Serdaroglu, E., Department of Pediatric Nephrology, Dr Behcet Uz Children Hospital, Izmir, Turkey; Taner, S., Department of Pediatric Nephrology, Faculty of Medicine, Ege University, Izmir, Turkey; Topaloglu, R., Department of Pediatric Nephrology, Faculty of Medicine, Hacettepe University, Ankara, Turkey; Vidal, E., Department of Pediatric Nephrology, University Hospital of Padova, Padova, Italy; Woroniecki, R., Department of Pediatric Nephrology, Stony Brook Children's Hospital, Stony Brook, NY, United States; Yel, S., Department of Pediatric Nephrology, Faculty of Medicine, Erciyes University, Kayseri, Turkey; Zieg, J., Department of Pediatric Nephrology, 2nf Faculty of Medicine, University Hospital Motol, Charles University, Praha, Czech Republic; Pape, L., Department of Pediatrics II, University Hospital Essen, Essen, Germany; Boyer, O., Hôpital Necker-Enfants malades, MARHEA, Institut Imagine, Université de Paris, Paris, France; Buder, K., Pediatric Department, University Hospital Carl Gustav Carus, Technical University, Dresden, Germany; Bulut, Ä°.K., Ege University Faculty of Medicine, Izmir, Turkey; Cornelissen, E.A.M., Radboud University Medical Center, Nijmegen, Netherlands; del Mar Espino Hernández, M., Hospital Universitario 12 de Octubre, Madrid, Spain; Hooman, N., Ali-Asghar Clinical Research Development Center, Iran University of Medical Sciences, Tehran, Iran; Kemper, M., Asklepios Medical School, Hamburg, Germany; Maquet, J., CHC Liège, Belgium; Santos, F., Pediatric Nephrology, Hospital Universitario Central de Asturias, University of Oviedo, Spain; Walden, U., Universitätsklinikum Kinderklinik Augsburg, Germany; The international TIN study group |
Background Acute tubulointerstitial nephritis (TIN) is a significant cause of acute renal failure in paediatric and adult patients. There are no large paediatric series focusing on the aetiology, treatment and courses of acute TIN. Patients, design and setting We collected retrospective clinical data from paediatric patients with acute biopsy-proven TIN by means of an online survey. Members of four professional societies were invited to participate. Results Thirty-nine physicians from 18 countries responded. 171 patients with acute TIN were included (54% female, median age 12 years). The most frequent causes were tubulointerstitial nephritis and uveitis syndrome in 31% and drug-induced TIN in 30% (the majority of these caused by non-steroidal anti-inflammatory drugs). In 28% of patients, no initiating noxae were identified (idiopathic TIN). Median estimated glomerular filtration rate (eGFR) rose significantly from 31 at time of renal biopsy to 86 mL/ min/1.73 m2 3-6 months later (p<0.001). After 3-6 months, eGFR normalised in 41% of patients (eGFR ≥90 mL/ min/1.73 m2), with only 3% having severe or end-stage impairment of renal function (<30 mL/min/1.73 m2). 80% of patients received corticosteroid therapy. Median eGFR after 3-6 months did not differ between steroid-treated and steroid-untreated patients. Other immunosuppressants were used in 18% (n=31) of patients, 21 of whom received mycophenolate mofetil. Conclusions Despite different aetiologies, acute paediatric TIN had a favourable outcome overall with 88% of patients showing no or mild impairment of eGFR after 3-6 months. Prospective randomised controlled trials are needed to evaluate the efficacy of glucocorticoid treatment in paediatric patients with acute TIN. © Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. |
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aciclovir; amoxicillin plus clavulanic acid; antiinfective agent; bee venom; chlorpheniramine maleate; corticosteroid; cotrimoxazole; flurbiprofen; herbaceous agent; hydrochlorothiazide; ibuprofen; immunosuppressive agent; ketoprofen; levetiracetam; mesalazine; methylprednisolone; midecamycin; morniflumate; mycophenolate mofetil; nonsteroid antiinflammatory agent; oxcarbazepine; paracetamol; penicillin G potassium; prednisolone; prednisone; toxic substance; anuria; arthralgia; Article; child; clinical feature; cohort analysis; controlled study; corticosteroid therapy; cross-sectional study; disease course; end stage renal disease; enuresis; estimated glomerular filtration rate; eye disease; fatigue; female; fever; flank pain; glucosuria; headache; health care survey; hematuria; human; huma |
BMJ Publishing Group |
20446055 |
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34049919 |
Article |
Q1 |
1132 |
3624 |
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No records
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225 |
Tandaju J.R., Ii W., Barati-Boldaji R., Raeisi-Dehkordi H. |
57222662533;57226738113;57204935735;57195065694; |
Meta-analysis of statin and outcomes of coronavirus disease 2019 (COVID-19): Reconsideration is needed |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
9 |
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2737 |
2739 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112531675&doi=10.1016%2fj.numecd.2021.06.009&partnerID=40&md5=51cf1abe5238935b3bcbca2d4b7a9969 |
Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
Tandaju, J.R., Faculty of Medicine Universitas Indonesia Dr. Cipto Mangunkusumo National General Central Hospital, Jakarta, Indonesia; Ii, W., The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China; Barati-Boldaji, R., Nutrition Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Raeisi-Dehkordi, H., Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran |
[No abstract available] |
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hydroxymethylglutaryl coenzyme A reductase inhibitor; human; COVID-19; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; SARS-CoV-2 |
Elsevier B.V. |
09394753 |
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34366177 |
Letter |
Q1 |
1127 |
3665 |
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277 |
Sigit F.S., Trompet S., Tahapary D.L., Sartono E., Willems van Dijk K., Yazdanbakhsh M., Supali T., Smit J.W.A., Rosendaal F.R., de Mutsert R. |
57213595986;22954837300;55944492500;6701506022;57202571815;7006269286;6602742029;24577861400;7004174530;16042051400; |
The associations of leptin and adiponectin with the metabolic syndrome in an Indonesian and a Dutch population |
2021 |
Nutrition, Metabolism and Cardiovascular Diseases |
31 |
8 |
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2426 |
2435 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108275064&doi=10.1016%2fj.numecd.2021.05.012&partnerID=40&md5=b98f561673afb80c486c693b20480984 |
Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands |
Sigit, F.S., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Trompet, S., Department of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Tahapary, D.L., Metabolic, Cardiovascular, and Aging Cluster, The Indonesian Medical Education and Research Institute, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Sartono, E., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Willems van Dijk, K., Department of Human Genetics, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Yazdanbakhsh, M., Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; Supali, T., Department of Parasitology, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine – Universitas Indonesia, Jalan Salemba Raya No 6, Jakarta, 10430, Indonesia; Smit, J.W.A., Department of Internal Medicine, Section of Endocrinology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands, Department of Internal Medicine, Radboud University Medical Center, Nijmegen, Netherlands; Rosendaal, F.R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands; de Mutsert, R., Department of Clinical Epidemiology, Leiden University Medical Center, Albinusdreef 2, Leiden, 2333 ZA, Netherlands |
Background and aims: At the same BMI, Asian populations develop cardiometabolic complications earlier than Western populations. We hypothesized that a different secretion of the adipocyte-derived hormones leptin and adiponectin plays a role and investigated the associations of the two hormones with the metabolic syndrome (MetS) in an Indonesian and a Dutch population. Methods and results: We performed cross-sectional analyses of the Netherlands Epidemiology of Obesity Study (n = 6602) and the SUGAR Scientific Programme Indonesia–Netherlands Study (n = 1461). We examined sex-stratified associations of leptin and adiponectin with MetS, using multivariate logistic regression including adjustment for total body fat. The mean (SD) leptin (mcg/L) were 4.7 (6.0) in Indonesian men, 18.6 (12.0) in Indonesian women, 9.1 (7.7) in Dutch men, and 23.4 (17.4) in Dutch women. The mean (SD) adiponectin (mg/L) were 5.7 (5.4), 7.5 (7.1), 6.6 (3.3), and 11.3 (4.9), respectively. Within the same BMI category, leptin concentrations were similar in the two populations, whereas adiponectin was lower in the Indonesian population. Per SD of leptin, adjusted prevalence odds ratios (ORs, 95%CI) of MetS were 0.9 (0.6–1.2) in Indonesian men, 1.1 (0.9–1.4) in Indonesian women, 2.2 (1.6–2.8) in Dutch men, and 1.2 (1.0–1.5) in Dutch women. Per SD of adiponectin, the ORs were 0.9 (0.7–1.2), 0.8 (0.7–1.0), 0.6 (0.6–0.8), and 0.4 (0.4–0.5), respectively. Conclusions: Despite lower adiponectin levels, adiponectin was not related to the MetS in the Indonesian population and can not explain their increased cardiometabolic risk at the same BMI. © 2021 The Author(s) |
Adiponectin; Asian; Leptin; The metabolic syndrome (MetS); Total body fat; Western |
adiponectin; ADIPOQ protein, human; biological marker; LEP protein, human; leptin; adolescent; adult; aged; blood; body mass; clinical trial; comparative study; cross-sectional study; female; human; Indonesia; male; metabolic syndrome X; middle aged; multicenter study; Netherlands; obesity; prevalence; randomized controlled trial (topic); risk assessment; sex factor; very elderly; young adult; Adiponectin; Adiposity; Adolescent; Adult; Aged; Aged, 80 and over; Biomarkers; Body Mass Index; Cardiometabolic Risk Factors; Cross-Sectional Studies; Female; Humans; Indonesia; Leptin; Male; Metabolic Syndrome; Middle Aged; Netherlands; Prevalence; Randomized Controlled Trials as Topic; Risk Assessment; Sex Factors; Young Adult |
Elsevier B.V. |
09394753 |
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34154890 |
Article |
Q1 |
1127 |
3665 |
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No records
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778 |
Miftahussurur M., Windia A., Syam A.F., Nusi I.A., Alfaray R.I., Fauzia K.A., Kahar H., Purbayu H., Sugihartono T., Setiawan P.B., Maimunah U., Kholili U., Thamrin H., Vidyani A., Doohan D., Waskito L.A., Rezkitha Y.A.A., Siregar G.A., Yamaoka Y. |
56323903000;57224923195;8443384400;56543515200;57215962996;57204649404;57218903823;57194162048;57194156387;6507682592;56543645400;57209663659;57204648560;57211316314;57204644036;57192177367;56543533600;56483277100;55183784100; |
Diagnostic value of 14C urea breath test for Helicobacter pylori detection compared by histopathology in indonesian dyspeptic patients |
2021 |
Clinical and Experimental Gastroenterology |
14 |
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291 |
296 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85108652378&doi=10.2147%2fCEG.S306626&partnerID=40&md5=ed8411e8e8e3e089aef5e0d750c1da27 |
Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia |
Miftahussurur, M., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Windia, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Syam, A.F., Division of Gastroenterology, Department of Internal Medicine, Faculty of Medicine, University of Indonesia, Jakarta, 10430, Indonesia; Nusi, I.A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Alfaray, R.I., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Fauzia, K.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan; Kahar, H., Department of Clinical Pathology, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Purbayu, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Sugihartono, T., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Setiawan, P.B., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Maimunah, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Kholili, U., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Thamrin, H., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Vidyani, A., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia; Doohan, D., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Waskito, L.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia; Rezkitha, Y.A.A., Institute of Tropical Disease, Universitas Airlangga, East Java, Surabaya, 60115, Indonesia, Faculty of Medicine, University of Muhammadiyah Surabaya, East Java, Surabaya, 60113, Indonesia; Siregar, G.A., Division of Gastroentero-Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Sumatra Utara, Medan, 20155, Indonesia; Yamaoka, Y., Gastroentero-Hepatology Division, Department of Internal Medicine, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, 60286, Indonesia, Department of Environmental and Preventive Medicine, Oita University, Faculty of Medicine, Yufu, 879-5593, Japan |
Purpose: Histopathology method is often used as a gold standard diagnostic for Helicobacter pylori infection in Indonesia. However, it requires an endoscopic procedure which is limited in Indonesia. A non-invasive method, such as14C Urea Breath Test (UBT), is more favorable; however, this particular method has not been validated yet. Patients and Methods: A total of 55 dyspeptic patients underwent gastroscopy and14C-UBT test. We used Heliprobe® UBT for UBT test. As for the histology, May-Giemsa staining of two gastric biopsies (from the antrum and corpus) were evaluated following the Updated Sydney System. Results: The Receiver Operating Characteristics analysis showed that the optimum cut-off value was 57 with excellence Area under Curve = 0.955 (95% CI = 0.861–1.000). By applying the optimum cut-off value, Heliprobe® UBT showed 92.31% for sensitivity, 97.62% for specificity, 92.31% for positive predictive value, 97.62% for negative predictive value, 38.77 for positive likelihood ratio, 0.0788 for negative likelihood ratio, and 96.36% for the accuracy. Conclusion: The14C-UBT is an accurate test for H. pylori diagnosis with excellent sensitivity, specificity, and accuracy. The different optimum cut-off points suggested that a validation is absolutely necessary for new test prior application to the new population. © 2021 Miftahussurur et al. |
Diagnostic; Helicobacter pylori; Infectious disease; UBT |
urea c 14; adult; Article; bacterium identification; controlled study; cross-sectional study; diagnostic accuracy; diagnostic value; dyspepsia; female; gastroscopy; Helicobacter infection; Helicobacter pylori; histopathology; human; human tissue; Indonesian; intermethod comparison; major clinical study; male; May Giemsa staining; middle aged; negative likelihood ratio; nonhuman; positive likelihood ratio; predictive value; receiver operating characteristic; sensitivity and specificity; statistical analysis; stomach antrum; stomach biopsy; stomach corpus; urea breath test; validation study |
Dove Medical Press Ltd |
11787023 |
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Article |
Q2 |
1113 |
3723 |
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