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675 |
Anton J., Sudibio S., Handoko H., Permata T.B.M., Kodrat H., Nuryadi E., Sofyan H., Susanto E., Mulyadi R., Aman R.A., Gondhowiardjo S. |
57328462500;57283461500;57204105168;57197808751;57210639849;57197806814;57328366500;57204423225;56403164500;36848942500;6508327402; |
Overexpression of c-Met is Associated with Poor Prognosis in Glioblastoma Multiforme: A Systematic Review and Meta-Analyses |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
10 |
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3075 |
3080 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118768203&doi=10.31557%2fAPJCP.2021.22.10.3075&partnerID=40&md5=1f49d5bfee87f5293659fdc801e6d63a |
Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Anton, J., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sudibio, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Handoko, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Permata, T.B.M., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kodrat, H., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Nuryadi, E., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sofyan, H., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Susanto, E., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Pathology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Mulyadi, R., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Radiology, dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Aman, R.A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Department of Neurology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Gondhowiardjo, S., Department of Radiation Oncology, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: The aim of this study is to evaluate the association of c-Met overexpression with survival of glioblastoma multiforme (GBM) patients. Methods: A systematic review with meta-analyses was conducted on related articles from PubMed, EBSCOhost, Scopus, and Cochrane databases with last updated search on October 31, 2020. A total of 7 studies regarding c-Met overexpression and overall survival (OS) and/or progression free survival (PFS) are included in this study. Results: All studies used immunohistochemistry to examine the expression of c-Met protein. The results showed that the positive rate of c-Met overexpression was detected in approximately 33,9% - 60,5% of GBM patients. c-Met overexpression was related to worse OS (HR: 1,74; 95% CI: 1,482-2,043; Z=6,756; p<0,001) and PFS (HR: 1,66; 95% CI: 1,327-2,066; Z=4,464; p<0,001) in GBM patients. Low heterogeneity of subjects was found in both OS and PFS analyses, I2 values were 7,8% and 0,0%, respectively. Conclusion: In conclusion, c-Met overexpression is significantly related to shorter OS and PFS in GBM patients, so c-Met can be considered as a potential prognostic indicator in GBM. © 2021. All Rights Reserved. |
c-Met; glioblastoma multiforme; prognosis; survival |
MET protein, human; scatter factor receptor; brain tumor; glioblastoma; human; Kaplan Meier method; meta analysis; metabolism; mortality; prognosis; Brain Neoplasms; Glioblastoma; Humans; Kaplan-Meier Estimate; Prognosis; Progression-Free Survival; Proto-Oncogene Proteins c-met |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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34710981 |
Article |
Q2 |
512 |
9866 |
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860 |
Wuyung P.E., Rahadiati F.B., Tjahjadi H., Salinah S., Kusmardi K., Kodariah R., Wiweko B. |
57192889605;57222312428;57210953454;57222311659;56966625300;14010667100;43061741400; |
Histopathology and Arid1a Expression in Endometriosis-Associated Ovarian Carcinoma (EAOC) Carcinogenesis Model with Endometrial Autoimplantation and DMBA Induction |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
2 |
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553 |
558 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102225233&doi=10.31557%2fAPJCP.2021.22.2.553&partnerID=40&md5=0851ed3cc33bf297db42accf77d7988a |
Department of Anatomical Pathology, Medicine Universitas Indonesia; Animal Research Facilities, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia; Specialty Programme in Anatomical Pathology, Department of Anatomical Pathology, Medicine Universitas Indonesia; Department of Obstetrics and Gynecology, Medicine Universitas Indonesia; Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia |
Wuyung, P.E., Department of Anatomical Pathology, Medicine Universitas Indonesia, Animal Research Facilities, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia; Rahadiati, F.B., Specialty Programme in Anatomical Pathology, Department of Anatomical Pathology, Medicine Universitas Indonesia; Tjahjadi, H., Department of Anatomical Pathology, Medicine Universitas Indonesia; Salinah, S., Department of Anatomical Pathology, Medicine Universitas Indonesia; Kusmardi, K., Department of Anatomical Pathology, Medicine Universitas Indonesia; Kodariah, R., Department of Anatomical Pathology, Medicine Universitas Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Medicine Universitas Indonesia, Indonesian Medical Education and Research Institute, Medicine Universitas Indonesia |
Background: Ovarian carcinoma is one of the most deadly malignancies in the gynecologic field. The cause is not yet known, and the clinical symptoms are not specific. Endometrioid carcinoma and ovarian clear cell carcinoma can originate from endometriosis and are known as endometriosis-related ovarian carcinoma (EAOC). Development of EAOC experimental animal models is needed for basic research and clinical preparation of human tissue tests. This study aimed to determine the role of the Arid1a gene mutation in the carcinogenetic process of EAOC in experimental animal models induced with DMBA. Methods: In this study, the EAOC experimental model was developed using the autoimplantation technique and DMBA induction. This study involved placebo surgery mice (sham), endometrial autoimplantation, and a combination of endometrial autoimplantation and DMBA induction, which were sacrificed at weeks 5, 10, and 20, respectively. Histopathological assessment and immunohistochemical Arid1a staining with an assessment of positive percentages were carried out on 200 cells. Results: This study produced 1 (20%) atypical endometriosis and 1 (20%) clear cell carcinoma at implantation and after 10 weeks of DMBA induction, and 100% endometrioid carcinoma in the DMBA-induced group. Arid1a staining did not show any significant difference (p = 0.313) in all groups. Conclusion: The combination of endometrial autoimplantation techniques and DMBA induction in the ovary produced atypical endometriosis, clear cell carcinoma, and endometrioid carcinoma, where time is an important factor. There was no significant difference in Arid1a expression between the treatment and control groups. © 2021. All Rights Reserved. |
Arid1a; DMBA; EAOC; Endometriosis; experimental animal model |
ARID1A protein, human; DNA binding protein; transcription factor; animal; autotransplantation; carcinoma; complication; disease model; endometriosis; endometrium; female; metabolism; ovary tumor; pathology; rat; transplantation; Animals; Carcinoma; Disease Models, Animal; DNA-Binding Proteins; Endometriosis; Endometrium; Female; Ovarian Neoplasms; Rats; Transcription Factors; Transplantation, Autologous |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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33639673 |
Article |
Q2 |
512 |
9866 |
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862 |
Putri M.I.A., Panigoro S.S., Harahap A.S., Pakasi T.A., Brahma B. |
57222261965;56790104300;57218511857;23980778600;55675752700; |
Acetic Acid and Iodine Staining for Determining Malignancy in Solid Tumors |
2021 |
Asian Pacific Journal of Cancer Prevention |
22 |
2 |
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463 |
469 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102041256&doi=10.31557%2fAPJCP.2021.22.2.463&partnerID=40&md5=a2eb3a6ba0cc657be963217a4e5d6cce |
Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Surgical Oncology, Dharmais Cancer Hospital, National Cancer Center, Jakarta, Indonesia |
Putri, M.I.A., Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Panigoro, S.S., Surgical Oncology Division, Department of Surgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Harahap, A.S., Department of Anatomical Pathology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Pakasi, T.A., Department of Community Medicine, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Brahma, B., Department of Surgical Oncology, Dharmais Cancer Hospital, National Cancer Center, Jakarta, Indonesia |
Objective: Surgical margin is an important prognostic factor in solid cancer surgery. Frozen section (FS), the gold standard for intraoperative surgical margin evaluation, requires extensive waiting time and expensive FS devices. The purpose of this diagnostic study was to verify whether multi-staining (MS) method with acetic acid and iodine could be used to differentiate malignant and non-malignant lesions of solid tumor. Methods: The study was conducted on patients with solid tumor who underwent surgery in the Surgical Oncology Division of Dr. Cipto Mangunkusumo General Hospital from December 2017 to April 2018. Samples measuring less than 5 mm, necrotic tissue sample, and patients who did not agree to participate in the study were excluded. Every specimen was divided into two, one side as unstained control and the other side as MS samples. MS samples were sprayed with 10% acetic acid combined with iodine. MS samples and unstained controls were sent for histopathologic results and the pathologist was blinded to group assignment. Acetowhitening reaction in the sample was an indication of a positive MS result, and the presence of malignant foci in the histopathology examination was classified as positive pathological results. Results: Five-hundredand-twenty samples were obtained from 150 patients. MS method was found to have sensitivity and specificity of 82%, and 63.5%, respectively. In subgroup analysis, we found that MS method has a sensitivity and specificity of 100% and 79.3%, respectively for epithelial breast tumor; 65.7% and 83.3%, respectively for thyroid nodules; and 94.1% and 33.3%, respectively for oral cavity tumors. MS method reacts positively to solid malignant tumor and negatively to benign tumor and normal tissue (from margin samples). Highest sensitivity was found for breast and oral cavity malignancy, and high specificity was found for thyroid cancers. Conclusion: This study provided an alternative staining method for intraoperative macroscopic surgical margin evaluation, especially for rural areas without frozen section facilities. © This work is licensed under a Creative Commons Attribution-Non Commercial 4.0 International License. |
Acetic acid; breast cancer; frozen section; iodine; oral cancer; solid tumor; thyroid cancer; vital staining |
acetic acid; coloring agent; dyes, reagents, indicators, markers and buffers; iodide; Lugol's solution; adolescent; adult; aged; child; cross-sectional study; female; frozen section; human; male; middle aged; neoplasm; pathology; sensitivity and specificity; staining; surgical margin; young adult; Acetic Acid; Adolescent; Adult; Aged; Child; Coloring Agents; Cross-Sectional Studies; Female; Frozen Sections; Humans; Indicators and Reagents; Iodides; Male; Margins of Excision; Middle Aged; Neoplasms; Sensitivity and Specificity; Staining and Labeling; Young Adult |
Asian Pacific Organization for Cancer Prevention |
15137368 |
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33639661 |
Article |
Q2 |
512 |
9866 |
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No records
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20 |
Kartika R.W., Alwi I., Yunir E., Waspadji S., Bardosono S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Suyatna F.D., Reksodiputro M.H. |
57223447932;15055173800;36520254800;8678136400;21933841000;57272979000;56275255400;57016857300;6507225348;56039633100;35090488800; |
A new innovation in topical diabetic foot ulcer; hyaluronic acid platelet-rich fibrin (HAPRF) gel - a study in inflammation and angiogenesis |
2021 |
Bali Medical Journal |
10 |
3 |
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901 |
908 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123104761&doi=10.15562%2fbmj.v10i3.2317&partnerID=40&md5=60a98c7a6392eaa4cf35d6bc5c895812 |
Medical Science Faculty of Medicine, Universitas Indonesia, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Departement Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kartika, R.W., Medical Science Faculty of Medicine, Universitas Indonesia, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia-Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Reksodiputro, M.H., Departement Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Background: Indonesia ranks 6th out of ten countries with the highest number of diabetes patients. An increase followed this condition in the prevalence of diabetic foot ulcers by around 15%. This study demonstrated the ability of combination of Platelet Rich Fibrin (PRF) and Hyaluronic Acid (HA) to reduce inflammation in diabetic foot ulcer (DFU) healing. Methods: In the baseline, all patients received the same treatment including wound debridement. There were 20 subjects divided into two groups; HAPRF and PRF. A part of sample was processed into lysate and stored in -80oC. The rest is applied as a topical therapy in DFU base on intervention. We analyzed the inflammation using two methods; swab in DFU and fibrin gel of HAPRF or PRF and ELISA on day-3 and day-7. We also measure the granulation index by digital photograph and analyze use ImageJ at the same time. Result: There were 20 diabetic patients with DFUs, performed analysis of IL-6 lysate gel HAPRF decrease significantly compare with PRF on day 3 (p= 0.038) and day-7 (p = 0.034). Granulation index evaluation, in HAPRF increase on day-3 (p = 0.043), day-7 (p = 0.049), and day-14 (p = 0.041). Conclusion: A-PRF +HA administration leads to reduce IL-6 levels, and accelerated wound healing of DFUs patients. HAPRF directly aids epithelialization and granulation index. © 2021, Sanglah General Hospital. All rights reserved. |
Diabetic foot ulcer; Fibrin; Granulation index; Hyaluronic acid; Inflammation; Platelet |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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#N/A |
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29 |
Ariwicaksono S.T.C., Rahardjo H.E. |
57212582959;37762030000; |
The comparison of intravesical hyaluronic acid and other modalities for the improvement of interstitial cystitis symptoms: A systematic reviews and meta-analysis |
2021 |
Bali Medical Journal |
10 |
3 |
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970 |
974 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121978362&doi=10.15562%2fbmj.v10i3.2510&partnerID=40&md5=0ddadc212b9221f4fe1b9ed43099c7b2 |
Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Ariwicaksono, S.T.C., Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia; Rahardjo, H.E., Department of Urology, Cipto Mangunkusumo National Hospital, Faculty of Medicine, Universitas Indonesia, Indonesia |
Background: Interstitial cystitis (IC) is a chronic inflammation of the bladder which causes unpleasant sensations. This condition considerably reduces patients’ quality of life. Intravesical hyaluronic acid is one of the new interventions for interstitial cystitis management, in which a thorough review and meta-analysis regarding this topic are still limited. This study aimed to compare the efficacy of intravesical hyaluronic acid with other intravesical treatment modalities available to treat interstitial cystitis. Method: Systematic literature searching with the main keywords of “interstitial cystitis” or “bladder pain syndrome” and “intravesical hyaluronic acid” was conducted. The main outcome of this study was pain assessment using a visual analogue scale (VAS) and Interstitial Cystitis Symptoms Index (ICSI), and problem index (ICPI). Meta-analysis was carried out when comparative studies were available. Eleven studies were obtained to assess intravesical hyaluronic acid’s effects, including three in the meta-analysis. The intravesical treatments found as a comparison were heparin and chondroitin sulphate. Result: There was significant heterogeneity among studies included in all parameters. The pooled analysis showed no significant difference in VAS reduction, improvement of ICSI and ICPI score (p = 0.11, p = 0.35, and p = 0.28, respectively) between hyaluronic acid and other intravesical treatments. Conclusion: There was no significant difference between hyaluronic acid and other intravesical treatments. However, further research with a larger sample is needed to confirm the best modalities in interstitial cystitis. © 2021, Sanglah General Hospital. All rights reserved. |
Hyaluronic acid; ICPI; ICSI; Interstitial cystitis; Pain; Symptoms; VAS |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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30 |
Alinda M.D., Christopher P.M., Listiawan M.Y., Endaryanto A., Suroto H., Rantam F.A., Hendradi E., Notobroto H.B., Menaldi S.L.S.W., Prakoeswa C.R.S. |
57202009260;57222755186;57202006621;55043187100;57148243900;6506692524;6507663471;56444366000;57192918198;57189894608; |
Comparative efficacy of topical adipocyte-derived mesenchymal stem cells-conditioned medium (Admsc-cm) and amniotic membrane mesenchymal stem cells-conditioned medium (amsc-cm) on chronic plantar ulcers in leprosy: A randomized controlled trial |
2021 |
Bali Medical Journal |
10 |
3 |
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958 |
963 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85121976659&doi=10.15562%2fbmj.v10i3.2747&partnerID=40&md5=2cb312268e5b8b08565af75e187acace |
Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia; Universitas Airlangga Teaching Hospital, Surabaya, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Banten, Tangerang, Indonesia; Department of Pediatric, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Cell and Tissue Bank, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Department of Orthopaedic & Traumatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Stem Cell Research and Development Center, Universitas Airlangga, East Java, Surabaya, Indonesia; Faculty of Pharmacy, Universitas Airlangga, East Java, Surabaya, Indonesia; Faculty of Public Health, Universitas Airlangga, East Java, Surabaya, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia |
Alinda, M.D., Post Graduate Doctoral Program, Faculty of Medicine, Universitas Airlangga, East Java, Surabaya, Indonesia, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia, Universitas Airlangga Teaching Hospital, Surabaya, Indonesia; Christopher, P.M., Faculty of Medicine, Universitas Pelita Harapan, Banten, Tangerang, Indonesia; Listiawan, M.Y., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia; Endaryanto, A., Department of Pediatric, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Suroto, H., Cell and Tissue Bank, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Department of Orthopaedic & Traumatology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia; Rantam, F.A., Stem Cell Research and Development Center, Universitas Airlangga, East Java, Surabaya, Indonesia; Hendradi, E., Faculty of Pharmacy, Universitas Airlangga, East Java, Surabaya, Indonesia; Notobroto, H.B., Faculty of Public Health, Universitas Airlangga, East Java, Surabaya, Indonesia; Menaldi, S.L.S.W., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National Central Public Hospital, Jakarta, Indonesia; Prakoeswa, C.R.S., Department of Dermatology and Venereology, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Academic Hospital, East Java, Surabaya, Indonesia, Leprosy Study Group, Institute of Tropical Diseases, Universitas Airlangga, Surabaya, Indonesia |
Introduction: Chronic Plantar Ulcer of Leprosy (CPUL), one of the debilitating disabilities and complications, poses a treatment challenge. Utilization of stem cells, specifically adipocyte-derived mesenchymal stem cells-conditioned medium (ADMSC-CM) and amniotic membrane mesenchymal stem cells-conditioned medium (AMSC-CM), may serve as a novel therapeutic option. This study aims to compare the efficacy of topical ADMSC-CM, topical AMSC-CM, and farmazertin gauze dressing (FGD) only on the healing of CPUL. Methods: In this randomized controlled trial, our study recruited 54 subjects with CPUL. Subjects were randomly assigned to topical ADMSC-CM (n = 16), topical AMSC-CM (n = 22), or FGD (n = 16) applied every three days for up to 8 weeks. Data were analyzed using SPSS version 20 for Windows. Results: Healing percentage increased each week in all groups. Statistic differences between groups (p <0.05) were observed for ulcer mean size and depth reduction from week three onwards. No adverse reactions or complications were reported. At the end of the study, based on clinically improved ulcers, topical ADMSC-CM (100.0%) were superior in improving the healing of CPULs compared to topical AMSC-CM (54.55%) and FGD only (50.0%). Conclusion: ADMSC-CM and AMSC-CM are potential therapeutic agents in the management of CPUL, with ADMSC-CM being superior in overall ulcer improvement. © 2021, Sanglah General Hospital. All rights reserved. |
ADMSC-CM; AMSC-CM; CPUL; Leprosy; Tropical Disease |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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#N/A |
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246 |
Ichwan S., Ningsih H.L., Aman R.A., Tandian D., Ashari S., Gunawan K., Nugroho S.W. |
57192906639;57226696258;36848942500;57192891173;57195942105;57195935319;57460519700; |
O6-methylguanine-dna methyltransferase (Mgmt) promoter methylation status of high-grade and low-grade gliomas |
2021 |
Bali Medical Journal |
10 |
2 |
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644 |
647 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112380308&doi=10.15562%2fbmj.v10i2.2316&partnerID=40&md5=c8e8a17690a11b9cc2f1729ff7a40de8 |
Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Ichwan, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ningsih, H.L., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Aman, R.A., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Tandian, D., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Ashari, S., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Gunawan, K., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia; Nugroho, S.W., Department of Neurosurgery, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia |
Background: O6-methylguanine-DNA methyltransferase (MGMT) is a DNA-repair enzyme that correlates with tumor resistance mechanism to chemotherapy. Methylation of the MGMT promoter inhibits the cells from producing MGMT and is useful to predict chemotherapy’s effectiveness with alkylating agents. This study aims to evaluate the MGMT promoter methylation of low-grade and high-grade glioma in the Neurosurgery Department of Cipto Mangunkusumo National General Hospital. Methods: We evaluated MGMT promoter methylation status using methylation-specific polymerase chain reaction in low and high-grade glioma patients who underwent surgical resection in the Neurosurgery Department of Cipto Mangunkusomo Hospital Jakarta. The result then correlated with age, sex, Karnofsky Performance Scale (KPS), and glioma grading. Data were analyzed using SPSS version 20 for Windows. Results: MGMT promoter methylation was observed more often in patients diagnosed with age more than 40 years old than in patients less than 40 years old (85.7% vs. 50.0%), also more in men than women (77.7% vs. 50.0%). In patients with KPS more than 70 and KPS 70 or less, methylation of MGMT promoter was observed in 70.0% and 57.1%, respectively. Based on tumor grading, MGMT promoter methylation was observed more often in low-grade gliomas (WHO grade II) than high-grade gliomas (WHO grade II and IV) (85.7% vs. 50.0%). There was no significant relationship between gender, age, KPS, malignancy degree, and Overall Survival (OS) to the MGMT promoter methylation (p>0.05). Conclusion: MGMT promoter methylation was observed less in the higher grade of tumors (grade IV), lower KPS, younger age at the time of diagnosis, and female patients, although the differences were not statistically significant. MGMT promoter methylation was observed more often in gliomas with oligodendroglioma components. © 2021, Sanglah General Hospital. All rights reserved. |
High-grade glioma; Low-grade glioma; Methylation; MGMT; Promoter |
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Sanglah General Hospital |
20891180 |
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Article |
#N/A |
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