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551 |
Turana Y., Tengkawan J., Chia Y.C., Shin J., Chen C.-H., Park S., Tsoi K., Buranakitjaroen P., Soenarta A.A., Siddique S., Cheng H.-M., Tay J.C., Teo B.W., Wang T.-D., Kario K. |
56083326000;57201472878;57204080905;54791393300;7501963868;8556278400;16065259000;6603376248;6507634613;57210091066;57026688600;24330212600;23570166200;7405566618;7102633390; |
Mental health problems and hypertension in the elderly: Review from the HOPE Asia Network |
2021 |
Journal of Clinical Hypertension |
23 |
3 |
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504 |
512 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097219445&doi=10.1111%2fjch.14121&partnerID=40&md5=67d4846f474282e2b6bd32d52a692db9 |
School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia; Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Jakarta, Indonesia; Punjab Medical Center, Lahore, Pakistan; Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; Center for Evidence-Based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Department of Internal Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
Turana, Y., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Tengkawan, J., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Chia, Y.C., Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Shin, J., Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Chen, C.-H., Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Park, S., Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; Tsoi, K., JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong; Buranakitjaroen, P., Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Soenarta, A.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Jakarta, Indonesia; Siddique, S., Punjab Medical Center, Lahore, Pakistan; Cheng, H.-M., Faculty of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan, Center for Evidence-Based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Public Health, National Yang-Ming University School of Medicine, Taipei, Taiwan; Tay, J.C., Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Teo, B.W., Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Wang, T.-D., Department of Internal Medicine, National Taiwan University College of Medicine, Taipei City, Taiwan; Kario, K., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
The “triple burden” of aging population, hypertension, and mental health problems making elderly in Asia is more vulnerable. There is evidence of a bidirectional relationship between mental health and hypertension, which results in lower quality of life, lower rate of treatment adherence, and higher mortality among elderly individuals. It is essential to overcome known barriers and care for the elderly with high-risk factors in order to address these burdens. This review revealed that elderly with hypertension were more likely to suffer from depression and anxiety. Therefore, debunking myths, creating awareness regarding mental health, and increasing access to mental health resources through holistic community-based programs would greatly reduce such problems and optimize the chances of success in controlling hypertension-related problems. © 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC |
Asia; elderly; hypertension; mental health |
antihypertensive agent; aged; anxiety; Asia; cardiovascular disease; cerebrovascular disease; community mental health service; comorbidity; depression; disease association; disease burden; elderly care; health care access; high risk population; human; hypertension; late life depression; life stress; loneliness; medication compliance; mental disease; mental health; motivation; patient compliance; Review; anxiety disorder; hypertension; mental health; quality of life; Aged; Anxiety Disorders; Asia; Humans; Hypertension; Mental Health; Quality of Life |
John Wiley and Sons Inc |
15246175 |
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33283971 |
Review |
Q2 |
909 |
5078 |
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552 |
Chang H.-C., Cheng H.-M., Chen C.-H., Wang T.-D., Soenarta A.A., Turana Y., Teo B.W., Tay J.C., Tsoi K., Wang J.-G., Kario K. |
57208131716;57026688600;7501963868;7405566618;6507634613;56083326000;23570166200;24330212600;16065259000;57211730247;7102633390; |
Dietary intervention for the management of hypertension in Asia |
2021 |
Journal of Clinical Hypertension |
23 |
3 |
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538 |
544 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85097029615&doi=10.1111%2fjch.14116&partnerID=40&md5=dd0dddd11a11196e4a83b9fd85ea06f2 |
Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan; Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan; Department of Medical Education, Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan; Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong; Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
Chang, H.-C., Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan; Cheng, H.-M., Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, Department of Medical Education, Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Chen, C.-H., Department of Medicine, Taipei Veterans General Hospital Su-Ao and Yuan-Shan Branch, Yilan, Taiwan, Faculty of Medicine, National Yang-Ming University School of Medicine, Taipei, Taiwan, Department of Medical Education, Center for Evidence-based Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, Institute of Public Health and Community Medicine Research Center, National Yang-Ming University School of Medicine, Taipei, Taiwan; Wang, T.-D., Division of Cardiology, National Taiwan University Hospital, Taipei, Taiwan; Soenarta, A.A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Turana, Y., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Teo, B.W., Division of Nephrology Department of Medicine, Yong Loo Lin School of Medicine, Singapore, Singapore; Tay, J.C., Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Tsoi, K., JC School of Public Health and Primary Care, The Chinese University of Hong Kong, Shatin, Hong Kong; Wang, J.-G., Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, the Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Kario, K., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan |
Hypertension is among the leading global risks for premature death. As the risks substantially increase along with the elevated blood pressure, a small reduction of blood pressure could have prevented numerous cardiovascular events in general population. Evidence has shown that dietary intervention is a cost-effective strategy that has been broadly advocated in the published guidelines. However, the implementation could be limited by different food cultures. This review details the mechanisms of each dietary intervention approach, evidence, and the implications in Asian populations, and the perspective of future research. © 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC |
dietary intervention; hypertension |
aldosterone; calcium; catecholamine; magnesium; potassium; renin; Asia; blood pressure regulation; body weight loss; calcium blood level; caloric restriction; cardiovascular risk factor; cost effectiveness analysis; cultural anthropology; DASH diet; diastolic blood pressure; diet supplementation; diet therapy; dietary pattern; disease association; electrolyte intake; evidence based medicine; fluid retention; food security; human; hyperinsulinemia; hypertension; ideal body weight; insulin resistance; lifestyle modification; magnesium blood level; Mediterranean diet; mortality; obesity; potassium blood level; potassium intake; practice guideline; renin angiotensin aldosterone system; Review; sodium restriction; sodium retention; sodium transport; sodium urine level; systolic blood pressure; |
John Wiley and Sons Inc |
15246175 |
|
33274585 |
Review |
Q2 |
909 |
5078 |
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553 |
Turana Y., Tengkawan J., Chia Y.C., Nathaniel M., Wang J.-G., Sukonthasarn A., Chen C.-H., Minh H.V., Buranakitjaroen P., Shin J., Siddique S., Nailes J.M., Park S., Teo B.W., Sison J., Ann Soenarta A., Hoshide S., Tay J.C., Prasad Sogunuru G., Zhang Y., Verma N., Wang T.-D., Kario K., the HOPE Asia Network |
56083326000;57201472878;57204080905;57220063330;57211730247;12793132900;7501963868;57211946145;6603376248;54791393300;57210091066;57204676117;8556278400;23570166200;36764809200;56545726300;6603859769;24330212600;57220061819;56183109800;7102496979;7405566618;7102633390; |
Hypertension and stroke in Asia: A comprehensive review from HOPE Asia |
2021 |
Journal of Clinical Hypertension |
23 |
3 |
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513 |
521 |
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5 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85096667710&doi=10.1111%2fjch.14099&partnerID=40&md5=85c747eb49b66c56895a7650e9a82984 |
School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia; Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Department of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Department of Cardiology, Hue University Hospital, Hue University, Hue City, Viet Nam; Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Punjab Medical Center, Lahore, Pakistan; University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines; Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; Division of Nephrology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore; Division of Nephrology, Department of Medicine, National University Health System, Singapore City, Singapore; Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines; Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; MIOT International Hospital, Chennai, India; College of Medical Sciences, Kathmandu University, Bharatpur, Nepal; Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Department of Physiology, King George's Medical University, Lucknow, India; Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan |
Turana, Y., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Tengkawan, J., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Chia, Y.C., Department of Medical Sciences, School of Healthcare and Medical Sciences, Sunway University, Bandar Sunway, Malaysia, Department of Primary Care Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia; Nathaniel, M., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Wang, J.-G., Department of Hypertension, Centre for Epidemiological Studies and Clinical Trials, The Shanghai Institute of Hypertension, Shanghai Key Laboratory of Hypertension, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Sukonthasarn, A., Cardiology Division, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand; Chen, C.-H., Department of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan; Minh, H.V., Department of Cardiology, Hue University Hospital, Hue University, Hue City, Viet Nam; Buranakitjaroen, P., Division of Hypertension, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand; Shin, J., Faculty of Cardiology Service, Hanyang University Medical Center, Seoul, South Korea; Siddique, S., Punjab Medical Center, Lahore, Pakistan; Nailes, J.M., University of the East Ramon Magsaysay Memorial Medical Center Inc., Quezon City, Philippines; Park, S., Division of Cardiology, Cardiovascular Hospital, Yonsei Health System, Seoul, South Korea; Teo, B.W., Division of Nephrology, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore, Division of Nephrology, Department of Medicine, National University Health System, Singapore City, Singapore; Sison, J., Section of Cardiology, Department of Medicine, Medical Center Manila, Manila, Philippines; Ann Soenarta, A., Department of Cardiology and Vascular Medicine, Faculty of Medicine, University of Indonesia-National Cardiovascular Center, Harapan Kita, Jakarta, Indonesia; Hoshide, S., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; Tay, J.C., Department of General Medicine, Tan Tock Seng Hospital, Singapore, Singapore; Prasad Sogunuru, G., MIOT International Hospital, Chennai, India, College of Medical Sciences, Kathmandu University, Bharatpur, Nepal; Zhang, Y., Divisions of Hypertension and Heart Failure, Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Verma, N., Department of Physiology, King George's Medical University, Lucknow, India; Wang, T.-D., Cardiovascular Center and Division of Cardiology, Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei City, Taiwan; Kario, K., Division of Cardiovascular Medicine, Department of Medicine, Jichi Medical University School of Medicine, Tochigi, Japan; the HOPE Asia Network |
Stroke is the primary cause of disability and vascular death worldwide, including Asia. Asian characteristics that differ from the West lead to higher stroke incidence. Stroke epidemiology studies in Asia have shown varying levels of mortality, incidence, prevalence, and burden of disease. Hypertension is the most prevalent risk factor found in Asia. Besides ethnicity that is associated with stroke incidence, both systolic blood pressure, diastolic blood pressure, and blood pressure variability are positively correlated with stroke incidence. Post-stroke cognitive impairment is one of the sequelae that affect one-third of stroke survivors and has become a significant public health concern that is often neglected despite its increasing prevalence. Therefore, it is very important to prevent recurrence by treating stroke optimally and effectively. Increasing awareness and treatment adherence to hypertension, the leading risk factor for stroke, became the main goal in several countries in Asia. © 2020 The Authors. The Journal of Clinical Hypertension published by Wiley Periodicals LLC. |
Asia; hypertension; stroke |
Asia; awareness; blood pressure variability; cerebrovascular accident; clinical effectiveness; dementia; diastolic blood pressure; disease burden; global health; human; hypertension; incidence; medication compliance; mortality rate; post stroke dementia; prevalence; recurrent disease; Review; risk factor; systolic blood pressure; blood pressure; cerebrovascular accident; hypertension; Asia; Blood Pressure; Humans; Hypertension; Incidence; Risk Factors; Stroke |
John Wiley and Sons Inc |
15246175 |
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33190399 |
Review |
Q2 |
909 |
5078 |
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No records
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409 |
Elhidsi M., Rasmin M., Prasenohadi |
57203157152;15754578700;55758911100; |
In-hospital mortality of pulmonary tuberculosis with acute respiratory failure and related clinical risk factors |
2021 |
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
23 |
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100236 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104769874&doi=10.1016%2fj.jctube.2021.100236&partnerID=40&md5=9a5aabc171edcb9f93c20e1128bf350e |
Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Elhidsi, M., Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Rasmin, M., Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia; Prasenohadi, Department of Pulmonology and Respiratory Medicine Faculty of Medicine, Universitas Indonesia – Persahabatan National Respiratory Referral Hospital, Jakarta, Indonesia |
Background/objective: Data on acute respiratory failure (ARF) in pulmonary tuberculosis (PTB) patients is limited. This study aims to investigate in-hospital mortality, its clinical risk factors and the accuracy of the existing scoring system in predicting in-hospital mortality. Methods: An observational prospective cohort study involving PTB patients with ARF in tertiary hospital, between January 2017 and December 2018, was conducted. The in-hospital mortality was predicted using the National Early Warning Score 2 (NEWS2), quick Sequential Organ Failure Assessment (qSOFA) and CRB-65. Regression models were run to analyze the clinical risk factors for in-hospital Mortality. Sensitivity and specificity of scoring systems were calculated using a Wilson score interval. Results: A total of 111 subjects were included. Most of subjects were hypoxemic type respiratory failure (68.5%), advanced lesions (62.2%), new cases (70.3%) and pneumonia co-infection (72.1%) patients. Invasive mechanical ventilation was utilized for 29.73% of cases. There were 53 (47.75%) in-hospital mortality cases and its risk factors were intensive phase treatment (3.34 OR; CI95% 1.27–8.78), P/F ratio < 100 (OR 4.30; CI 95% 1.75–10.59) and renal insufficiency (4.09 OR; CI95% 1.46–11.49). The sensitivity and specificity of NEWS2 ≥ 6, qSOFA ≥ 2 and CRB-65 ≥ 2 were 62.26% and 67.24%; 60.38% and 72.41%; 41.51% and 84.48% respectively. Conclusions: Most of PTB with ARF were new cases, advanced lesion and hypoxemic type respiratory failure. Intensive phase treatment, severe hypoxemia and renal insufficiency are independent predictors of in-hospital mortality in PTB patients with ARF. NEWS2, qSOFA and CRB-65 scores were poor to predict the in-hospital mortality. © 2021 The Author(s) |
Acute respiratory failure; In-hospital mortality; Pulmonary tuberculosis; Tuberculosis |
steroid; tuberculostatic agent; acute respiratory failure; adult; aged; Article; cohort analysis; coinfection; confidence interval; controlled study; CRB-65 score; diagnostic test accuracy study; female; human; in-hospital mortality; invasive ventilation; kidney failure; lung tuberculosis; major clinical study; male; National Early Warning Score 2; observational study; odds ratio; pneumonia; prospective study; quick Sequential Organ Failure Assessment Score; regression analysis; risk assessment; risk factor; scoring system; sensitivity and specificity; tertiary care center |
Elsevier Ltd |
24055794 |
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Article |
Q3 |
585 |
8643 |
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422 |
Putra M.D., Rahyussalim A.J., Jusman S.W.A., Iswanti F.C., Sadikin M. |
57221617403;55212166100;36518792100;57192920851;36981411100; |
Phagocytosis and the antigen-processing abilities of macrophages derived from monocytes in spinal tuberculosis patients |
2021 |
Journal of Clinical Tuberculosis and Other Mycobacterial Diseases |
23 |
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100215 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099630069&doi=10.1016%2fj.jctube.2021.100215&partnerID=40&md5=2548fbe746aaf9e6e815fb1375351254 |
Master's Program in Biomedical Science, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia10430, Indonesia; Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta15419, Indonesia; Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia; Center of Hypoxia and Oxidative Stress Studies, Indonesia |
Putra, M.D., Master's Program in Biomedical Science, Master's Programme in Biomedical Sciences, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Faculty of Medicine and Health, Universitas Muhammadiyah Jakarta15419, Indonesia; Rahyussalim, A.J., Department of Orthopedics and Traumatology, Faculty of Medicine, Universitas Indonesia-Ciptomangunkusumo Hospital10430, Indonesia; Jusman, S.W.A., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia; Iswanti, F.C., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia; Sadikin, M., Department of Biochemistry and Molecular Biology, Faculty of Medicine, Universitas Indonesia10430, Indonesia, Center of Hypoxia and Oxidative Stress Studies, Indonesia |
This study examined the hypothesis that there is an impairment of macrophageal function in spinal TB. We examined macrophageal functions in spinal TB patients. Monocytes were isolated from peripheral blood mononuclear cells (PBMCs) of five spinal TB patients and five healthy persons as control. The isolated monocytes were cultured with stimulation of macrophage colony-stimulating factor (M-CSF) for seven days for maturation. The phagocytic ability of the macrophages derived from monocytes was measured. Also, nitric oxide (NO), myeloperoxidase (MPO), beta-glucuronide, and acid phosphatase activity was investigated. We found that the monocytes collected from patient PBMCs were significantly fewer than those of the control group (2992.103 vs. 6474.103 (cells/mL)). There were also fewer macrophages that had adhered to sheep red blood cells (SRBC) (598.103 vs. 264.103 (cells/mL)). However, NO production (2346 vs. 325.17 (µmol/gram of protein)), and the MPO (570.7 vs. 17.4 (unit/mg), beta-glucuronide (0.149 vs. 0.123 (μmol/hour/100 mg of protein)), and acid phosphatase activities (1776.9 vs. 287.9 (μmol/hour/100 mg of protein)) of the macrophages in the spinal TB group were markedly higher than in the healthy group. Despite the low adhesion to foreign bodies, the intracellular processing of TB macrophages, including oxidative activity and lysosome function, was significantly high. These results suggested the impairment of macrophageal function in spinal TB. Possibly, there is a dominance of innate non-specific immunity in spinal TB infection. © 2021 The Author(s) |
Acid phosphatase; Beta-glucuronidase; Macrophage; Myeloperoxidase; Nitric oxide; Spinal tuberculosis |
acid phosphatase; beta glucuronidase; colony stimulating factor 1; glucuronide; myeloperoxidase; nitric oxide; adult; antigen presentation; Article; cell adhesion; cell maturation; clinical article; controlled study; enzyme activity; female; foreign body; human; human cell; lysosome; macrophage; macrophage culture; macrophage function; male; monocyte; oxidation; phagocytosis; priority journal; sheep erythrocyte; tuberculous spondylitis |
Elsevier Ltd |
24055794 |
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Article |
Q3 |
585 |
8643 |
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No records
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360 |
Yunir E., Tahapary D.L., Tarigan T.J.E., Harbuwono D.S., Oktavianda Y.D., Kristanti M., Iswati E., Sarumpaet A., Soewondo P. |
36520254800;55944492500;36057746500;36056341600;57224499358;57208222835;57224505254;57193017794;23475336100; |
Non-vascular contributing factors of diabetic foot ulcer severity in national referral hospital of Indonesia |
2021 |
Journal of Diabetes and Metabolic Disorders |
20 |
1 |
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805 |
813 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85107722068&doi=10.1007%2fs40200-021-00827-x&partnerID=40&md5=b307a628bc17237466c173d4d63b13aa |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tahapary, D.L., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Harbuwono, D.S., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Oktavianda, Y.D., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Kristanti, M., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iswati, E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sarumpaet, A., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: Diabetic foot ulcer (DFU) is a common chronic complication of type 2 diabetes mellitus (T2DM) in Indonesia, with a prevalence of 7.3%. However, the characteristics of these patients remain unclear. We investigated the characteristics of patients with DFU without peripheral arterial disease (PAD) and analyzed non-vascular factors related to severity of DFU in a tertiary care national referral hospital in Indonesia. Methods: This was a cross-sectional study including 123 hemodynamically stable DFU patients without PAD recruited from Dr. Cipto Mangunkusumo National General Hospital, Jakarta, Indonesia from 2010–2015. Results: DFU patients were predominantly over 50 years old (75.6%) and diagnosed with T2DM for 5 years with poor glycemic control (82.7%) and peripheral neuropathy (91.3%). Most patients had anemia (86.7%), leukocytosis (84.6%), and were undernourished, as characterized by a low lipid profile (90.8%) and hypoalbuminemia (83.7%). Most had extensive size of ulcer at the initial visit, with a median size of 16.23 (2.92–60.16) cm2. Ulcers were mostly located of the forefoot (62.5%) and were caused by mechanical trauma (46.2%). Bivariate analysis revealed that significant factors for the development of DFU were related to DFU size, including duration of T2DM (p = 0.04), leukocyte levels (p = < 0.01), and thrombocyte levels (p = < 0.01). Multivariate analysis showed leucocyte (p = 0.03) and thrombocyte (p = 0.023) had significantly correlated with DFU severity. Conclusion: Leucocyte and thrombocyte may be the greatest contributing non-vascular factors for severity of DFU in Indonesia. © 2021, Springer Nature Switzerland AG. |
Diabetic foot ulcer; Leucocyte; Non-vascular factor; Thrombocyte |
adult; anemia; Article; clinical feature; controlled study; correlational study; cross-sectional study; diabetic foot; disease association; disease course; disease duration; disease severity; female; forefoot; glycemic control; hemodynamics; human; hypoalbuminemia; Indonesia; leukocyte count; leukocytosis; lipid analysis; major clinical study; male; malnutrition; non insulin dependent diabetes mellitus; peripheral neuropathy; platelet count; tertiary care center |
Springer Science and Business Media Deutschland GmbH |
22516581 |
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619 |
8164 |
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