No records
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94 |
Subahar R., Susanto L., Aidilla R., Aulia A.P., Yulhasri Y., Winita R., Lubis N.S., Sari I.P. |
6508197883;6507704130;57365800900;57366528800;57225180520;57220782528;57222661567;57197543698; |
In vitro experiments of Pediculus humanus capitis (Phthiraptera: Pediculidae) resistance to permethrin and 6-paradol in East Jakarta: Detoxification enzyme activity and electron microscopic changes in lice |
2021 |
Veterinary World |
14 |
11 |
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3065 |
3075 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120814548&doi=10.14202%2fvetworld.2021.3065-3075&partnerID=40&md5=1d1646983a8b7f7da98a7d4f5896e795 |
Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia |
Subahar, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Susanto, L., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Aidilla, R., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Aulia, A.P., Medical Doctor Program, Faculty of Medicine, University of Indonesia, Jl. Salemba 4, Jakarta, 10430, Indonesia; Yulhasri, Y., Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Indonesia, Jln. Salemba Raya 4, Jakarta, 10430, Indonesia; Winita, R., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Lubis, N.S., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia; Sari, I.P., Department of Parasitology, Faculty of Medicine, University of Indonesia, Jl. Salemba 6, Jakarta, 10430, Indonesia |
Background and Aim: Pediculus humanus capitis, the human head louse, remains a global health problem. This study evaluated the resistance of head lice to permethrin and 6-paradol mediated by in vitro detoxification enzyme activity experiments and to describe physical changes in the lice using scanning electron microscopy (SEM). Materials and Methods: The adult stages of P. h. capitis were collected from patients exposed to 1% permethrin and three different concentrations of 6-paradol (0.00005%, 0.0001%, and 0.00015%) using a filter paper diffusion bioassay. Healthy P. h. capitis adults served as the control. The in vitro bioassays were conducted after 10, 20, 30, and 60 min of exposure. The activities of acetylcholinesterase (AChE), glutathione S-transferase (GST), and oxidase were analyzed. Physical changes in the lice were analyzed using SEM. Results: Permethrin and 6-paradol exhibited low toxicity against the lice. At 60 min, 1% permethrin had killed 36.7% of the lice present, while 6-paradol had killed 66.7-86.7%. Permethrin induced significantly elevated AChE, GST, and oxidase activity; 6-paradol also caused significantly elevated AChE, GST, and oxidase activity. Permethrin did not cause any ultrastructural morphological changes on the lice, while 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. Conclusion: This in vitro experimental of P. h. capitis is the first study to report P. h. capitis in East Jakarta shows complete resistance to permethrin and 6-paradol, and to describe the associated increase in AChE, GST, and oxidase activity. It was observed that 6-paradol severely damaged the head, thorax, respiratory spiracles, and abdomen of the dead lice. © 2021 Veterinary World. All rights reserved. |
6-paradol; Detoxifying enzyme; Electron microscopy; Pediculus humanus capitis; Permethrin; Resistance |
6 paradol; acetylcholinesterase; chitin; glutathione transferase; oxidoreductase; permethrin; phenol derivative; unclassified drug; Article; bioassay; controlled study; detoxification; diffusion; enzyme activity; enzyme linked immunosorbent assay; hair loss; LT50; LT90; nonhuman; Pediculus humanus capitis; scanning electron microscopy; ultrastructure |
Veterinary World |
09728988 |
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Article |
Q2 |
550 |
9187 |
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99 |
Herawati F., Yulia R., Wiyono H., Massey F.K., Muliani N., Kantono K., Soemantri D., Andrajati R. |
57194722742;56768083700;57321279000;57321051400;57222261946;56580346400;36640659100;9940247700; |
Discordance to ashp therapeutic guidelines increases the risk of surgical site infection |
2021 |
Pharmaceuticals |
14 |
11 |
1088 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118387727&doi=10.3390%2fph14111088&partnerID=40&md5=f3621ba3decf103d84295afa3e55e549 |
Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia |
Herawati, F., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia, Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia; Yulia, R., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Wiyono, H., Faculty of Medicine, Universitas Surabaya, Surabaya, 60293, Indonesia; Massey, F.K., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Muliani, N., Department of Clinical and Community Pharmacy, Faculty of Pharmacy, Universitas Surabaya, Surabaya, 60293, Indonesia; Kantono, K., Department of Food Science, Auckland University of Technology, Private Bag 92006, Auckland, 1142, New Zealand; Soemantri, D., Department of Medical Education, Faculty of Medicine, Universitas Indonesia, Depok, 16424, Indonesia; Andrajati, R., Department of Pharmacology and Clinical Pharmacy, Faculty of Pharmacy, Universitas Indonesia, Depok, 16424, Indonesia |
Clean surgery without contamination does not require prophylactic antibiotics, but there are high-risk surgical procedures that may cause infection and/or involve vital organs such as the heart, brain, and lungs, and these indeed require the use of antibiotics. This study aimed to determine the quantity of antibiotic use based on the defined daily dose (DDD) per 100 bed days and the quality of antibiotic use based on the percentage of concordance with The American Society of Health-System Pharmacists (ASHP) therapeutic guidelines (i.e., route of administration, time of administration, selection, dose, and duration). This includes the profiles of surgical site infection (SSI) in surgical patients from January through June 2019. The study subjects were 487 surgical patients from two hospitals who met the inclusion criteria. There were 322 patients out of 487 patients who had a clean surgical procedure. Ceftriaxone (J01DD04) was the most used antibiotic, with a total DDD/100 bed days value in hospitals A and B, respectively: pre-surgery: 14.71, 77.65, during surgery: 22.57, 87.31, and postsurgery: 38.34, 93.65. In addition, 35% of antibiotics were given more than 120 min before incision. The lowest concordance to ASHP therapeutic guideline in hospital A (17.6%) and B (1.9%) was antibiotic selection. Two patients experienced SSI with bacterial growths of Proteus spp., Staphylococcus aureus, Staphylococcus epidermidis, and Escherichia coli. The usage of prophylactic antibiotics for surgical procedures was high and varied between hospitals. Hospital B had significantly lower concordance to antibiotic therapeutic guidelines, resulting to a higher infection rate, compared with hospital A. ASHP adherence components were then further investigated, after which antibiotic dosing interval and injection time was found to be a significant predictor for positive bacterial growth based on logit–logistic regression. Further interventions and strategies to implement antibiotic stewardship is needed to improve antibiotic prescriptions and their use. © 2021 by the authors. Licensee MDPI, Basel, Switzerland. |
Antibiotic stewardship; Defined daily dose; Hospital; Surgical site infection |
amoxicillin; amoxicillin plus clavulanic acid; ampicillin; antibiotic agent; beta lactamase inhibitor; cefadroxil; cefazolin; cefepime; cefixime; cefoperazone; cefotaxime; cefoxitin; ceftazidime; ceftriaxone; chloramphenicol; ciprofloxacin; clindamycin; cotrimoxazole; fosfomycin; gentamicin; levofloxacin; meropenem; metronidazole; moxifloxacin; norfloxacin; ofloxacin; oxacillin; sulbactam; sultamicillin; tetracycline; vancomycin; adult; aged; antibiotic sensitivity; antimicrobial stewardship; Article; bacterial growth; bacterium culture; drug choice; drug use; Escherichia coli; female; human; infection rate; infection risk; intraoperative period; length of stay; major clinical study; male; medical society; middle aged; observational study; postoperative period; practice guideline; preopera |
MDPI |
14248247 |
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Article |
Q1 |
1295 |
2918 |
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135 |
Pujianto D., Permatasari S. |
8745734300;57408686700; |
Mouse CD52 is predominantly expressed in the cauda epididymis, regulated by androgen and lumicrine factors |
2021 |
Journal of Human Reproductive Sciences |
14 |
4 |
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350 |
355 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122693572&doi=10.4103%2fjhrs.jhrs_29_21&partnerID=40&md5=442cc066428b3f1038737d1f1d81f1cc |
Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, 10430, Indonesia; Department of Biology, Faculty of Medicine, Universitas Palangka Raya, Indonesia |
Pujianto, D., Department of Biology, Faculty of Medicine, Universitas Indonesia, Jl. Salemba Raya 6, Jakarta, 10430, Indonesia; Permatasari, S., Department of Biology, Faculty of Medicine, Universitas Palangka Raya, Indonesia |
Background: Sperm maturation takes place through contact between sperm and proteins produced in the epididymal lumen. CD52 had been characterised in the sperm; however, the expression and its regulation in the epididymis are mostly unknown. Aim: This study aimed to analyse the expression and regulation of CD52 in the mouse epididymis. Setting and Design: Experimental design was used in this study. Materials and Methods: Epididymis tissues from mice strain Deutch Democratic Yokohama were used as sources of total RNA. Bioinformatic tool was used to predict signal peptides. Quantitative real-Time reverse transcription-polymerase chain reaction was used to analyse tissue distribution, androgen, testicular factors dependency and postnatal development. Statistical Analysis: One-way analysis of variance was used to analyse differences between treatment and control untreated group. P < 0.05 was determined as a significant difference. Results: CD52 amino acid sequence contains a signal peptide, indicating it is a secretory protein. CD52 exhibited region-specific expression in the epididymis, with the highest level being in the cauda. CD52 expression was regulated by androgen indicated by a significant downregulation at day 1 and day 3 following a castration (P < 0.05). Dependency on androgen was confirmed by injection of exogenous testosterone which prevented downregulation by 50%. Moreover, lumicrine factors also influenced CD52 expression indicated by ligation of efferent duct which also reduced expression at day 1 to day 5 following the ligation (P < 0.05). CD52 expression was developmentally regulated. This was shown by increase in the level of expression starting at day 15 postnatally. Conclusion: CD52 shows characteristics of genes involved in sperm maturation in the epididymis. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Androgen; CD52; Epididymis; Lumicrine; Sperm maturation |
androgen; bromethol; CD52 antigen; hormone; lumicrine; RNA; signal peptide; testosterone; unclassified drug; amino acid sequence; androgen therapy; animal experiment; animal tissue; antigen expression; Article; castration; cauda epididymis; controlled study; down regulation; epididymis; male; mouse; nonhuman; postnatal development; quantitative analysis; real time reverse transcription polymerase chain reaction; spermatozoon maturation; tissue distribution |
Wolters Kluwer Medknow Publications |
09741208 |
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Article |
Q3 |
484 |
10359 |
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198 |
Kartika R.W., Alwi I., Yunir E., Waspadji S., Suyatna F.D., Bardosono S., Immanuel S., Sungkar S., Rachmat J., Silalahi T., Reksodiputro M.H. |
57223447932;15055173800;36520254800;8678136400;56039633100;21933841000;57272979000;57016857300;6507225348;56275255400;35090488800; |
Efficacy of Combining Hyaluronic Acid and Platelet-Rich Fibrin in Diabetic Foot Ulcer |
2021 |
Jordan Journal of Biological Sciences |
14 |
3 |
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607 |
611 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85115791952&partnerID=40&md5=76c1dc1bbdde331f901d412f6b6a83ba |
Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Kartika, R.W., Doctoral Program in Medical Science Faculty of Medicine Universitas Indonesia, Department of Thoracic, Cardiac and Vascular Surgery, Faculty of Medicine Krida Wacana Christian University, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Indonesia; Bardosono, S., Department of Clinical Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia – Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Sungkar, S., Department of Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Faculty of Medicine Krida Wacana Christian University, Jakarta, Indonesia; Reksodiputro, M.H., Department of Otorhinolaryngology, Facial Plastic Reconstructive Division, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Objectives: A chronic complication of type-2 diabetes mellitus (DMT-2) is Diabetic Foot Ulcer (DFU). The main treatment used in DFU is wound cleansing, followed by dressing the wound as a local control to increase tissue granulation and epithelialization. This study aims to compare the efficacy of the combination of Hyaluronic Acid with Platelet Rich Fibrin (HAPRF) and Platelet Rich Fibrin alone in DFU. Methods: We conducted a randomized controlled trial from July 2019 to April 2020. The study was approved by the Ethics Committee of the Faculty of Medicine of Universitas Indonesia ID 0855 / UN2.F1 / ETIK / 2018. Informed consent was obtained from the patients. This was a randomized clinical study to compare the efficacy of HAPRF and PRF in DFU one week post debridement. Twenty DFU samples were collected divided into 2 treatment groups: topical treatment using HAPRF compare with PRF alone. Assessment for wounds improvement was recorded using a digital camera 48 mega pixel with an accuracy of 0.1% on day-0, 3, 7, and 14. The results of the wound photographs were processed using ImageJ software. The granulation area (GA) and wound area (WA) were evaluated by IBM SPSS software v.20. The general data description was presented in median (range) value and parameter’s differences were conducted using Mann–Whitney test Results: The two treatment groups showed insignificant difference in characteristics between both group before intervention. The mean granulation width after two weeks of use HAPRF was 97.4% and PRF was 81.9%. Statistical analysis using Mann Whitney test showed granulation area of HAPRF group was significantly different compared with PRF group on day-3(p=0.047), day-7 ( p = 0.004) and day-14 ( p < 0.001). At the end of the wound healing process, the HAPRF group was significantly different compared with PRF group on Δ day 0−3 ( p=0.048), Δ day 0−7 ( p = 0.039), and Δ day 0−14 ( p = 0.023). Conclusions: HAPRF improves wound healing rate through increasing granulation tissue and epithelialization compared with PRF only in diabetic foot ulcer after 2 weeks post debridement compared to PRF. © 2021, Jordan Journal of Biological Sciences. All Rights Reserved. |
Delta Wound Area; Diabetic ulcer; Granulation Area; Hyaluronic Acid; Platelet Rich Fibrin |
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Hashemite University |
19956673 |
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Article |
Q3 |
216 |
18398 |
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233 |
Sunarno S., Puspandari N., Sariadji K., Febriyana D., Saraswati T.F.R.D., Maha M.S., Handayani S., Lestari C.S.W., Fitriana V.S.F., Yuniar Y., Pracoyo N.E., Pradono J., Siswanto S., Multihartina P., Anggraeni N.D., Hidayati L.N., Sukandar A., Safaat H., Karyanti M.R. |
57441531200;56786591900;57199654249;57222530233;57462625600;6603127192;26023188400;57194534757;57462459800;57219339473;57273150400;57462947000;56613530000;56708801900;57218324975;57463104500;57463428900;57462459900;56290680800; |
Microbiological and Clinical Aspects of Diphtheria-Confirmed Cases from Capital City of Indonesia, Jakarta, and Surrounding Areas in 2017 |
2021 |
Jundishapur Journal of Microbiology |
14 |
8 |
e118751 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85125038649&doi=10.5812%2fJJM.118751&partnerID=40&md5=cd6599282018ea61a451d60e8fe3eb1a |
Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; World Health Organization, South-East Asia Regional Office, New Delhi, India; Jakarta Provincial Health Office, Jakarta, Indonesia; West Java Provincial Health Office, Bandung, Indonesia; Banten Provincial Health Office, Serang, Indonesia; Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia |
Sunarno, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Puspandari, N., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Sariadji, K., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Febriyana, D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Saraswati, T.F.R.D., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Maha, M.S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Handayani, S., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Lestari, C.S.W., Centre for Research and Development of Biomedical and Basic Health Technology, National Institute of Health Research and Development, Jakarta, Indonesia; Fitriana, V.S.F., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Yuniar, Y., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Pracoyo, N.E., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Pradono, J., Centre for Research and Development of Public Health Efforts, Jakarta, Indonesia; Siswanto, S., World Health Organization, South-East Asia Regional Office, New Delhi, India; Multihartina, P., Centre for Research and Development of Human Resourches and Health Services, Jakarta, Indonesia; Anggraeni, N.D., Coordinating Ministry of Human Development and Cultural, Jakarta, Indonesia; Hidayati, L.N., Jakarta Provincial Health Office, Jakarta, Indonesia; Sukandar, A., West Java Provincial Health Office, Bandung, Indonesia; Safaat, H., Banten Provincial Health Office, Serang, Indonesia; Karyanti, M.R., Department of Pediatric, Faculty of Medicine, University of Indonesia, Jawa Barat, Indonesia |
Background: The World Health Organization reported Indonesia as one of the countries with the most prevalent cases of diphtheria worldwide. The microbiological aspects of diphtheria-inducing bacteria are of great significance in tracing disease transmission and case management. However, clinical aspects are critical for updating clinical features and case management in the field, which may sometimes differ from theoretical foundations. Objectives: This study aimed to identify the microbiological and clinical aspects, including molecular typing and case fatality rates, in diphtheria-confirmed cases from the capital city of Indonesia, Jakarta, and surrounding areas in 2017. Methods: The microbiological aspect of 40 diphtheria-confirmed cases were obtained by re-identify diphtheria-inducing bacteria isolated from the samples, while the clinical aspects of the cases were obtained from the medical records and epidemiological data. The chi-square test was used to examine the correlation between fatal cases and myocarditis and diphtheria antitoxin administra-tion delay. In this study, P ≤ 0.05 was set as the significance level. Results: All 40 diphtheria confirmed cases were induced by toxigenic Corynebacterium diphtheriae with two biotypes, namely inter-medius (60.0%) and mitis (40.0%). There are six sequence types of bacteria with two main sequence types, ie, ST534 (46.4%) and ST377 (35.7%). The proportions of cases that had a fever and sore throat were 72.5% and 77.5%, respectively; however, the prevalence rates of the cases with pseudomembrane and bull neck were 100% and 47%, respectively. Most cases were administered a combination of penicillin or erythromycin with other antibiotics (40%), and 22.5% of the cases only received penicillin. Myocarditis was noticed in three fatal cases, and their relationship was statistically significant (P = 0.000). All five fatal cases (12.5% of cases) received diphtheria antitoxin (DAT) lately or had not received it yet. Conclusions: Toxigenic C. diphtheriae with two biotypes (namely mitis and intermedius) and two main sequence types (ie, ST534 and ST377) was the causative agent of diphtheria-confirmed cases from Jakarta and surrounding areas in 2017. It was also concluded that those fatal cases were correlated with myocarditis complications. © 2021, Author(s). |
Corynebacterium diphtheriae; Diphtheria; Indonesia; Jakarta |
antibiotic agent; antitoxin; erythromycin; glycerol; penicillin G; adolescent; airway obstruction; Article; bacterium identification; bull neck; case fatality rate; child; clinical assessment; clinical feature; conceptual framework; controlled study; correlation analysis; Corynebacterium diphtheriae; Corynebacterium pseudotuberculosis; descriptive research; diphtheria; disease transmission; female; fever; headache; human; Indonesia; intermedius; major clinical study; male; medical record; microbiology; microscopy; mitis; molecular typing; multilocus sequence typing; polymerase chain reaction; preschool child; pseudomembrane; school child; sequence analysis; sore throat; toxicity testing; vaccination; World Health Organization |
Kowsar Medical Institute |
20083645 |
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Article |
Q3 |
281 |
15495 |
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264 |
Lesmana C.R.A., Mandasari B.K.D. |
8977683000;57223222627; |
The new era of endoscopic ultrasound in biliary disorders |
2021 |
Clinical Journal of Gastroenterology |
14 |
4 |
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923 |
931 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105339459&doi=10.1007%2fs12328-021-01419-1&partnerID=40&md5=e46386a86669ce1318bf2c07a7eeb843 |
Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia; Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia |
Lesmana, C.R.A., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia, Digestive Disease & GI Oncology Centre, Medistra Hospital, Jakarta, Indonesia; Mandasari, B.K.D., Division of Hepatobiliary, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Medical Faculty Universitas Indonesia, JL. Diponegoro 71, Jakarta, DKI Jakarta 10430, Indonesia |
Biliary obstruction is one of challenging biliary disorders in gastroenterology field, where this long-standing condition can also lead to portal hypertension and multi-disciplinary teamwork is usually needed to manage this problem. Biliary drainage is the primary management to prevent prolonged cholestasis. Biliary system with its thin-walled and tubular structure sometimes makes the diagnosis and therapeutic not easy to approach. Over the past 3 decades, numerous new and modern diagnostic and therapeutic modalities have been developed to manage the complex biliary problems. It is well known that endoscopic retrograde cholangiopancreatography (ERCP), percutaneous transhepatic biliary drainage (PTBD), and surgical procedure are common procedures in managing biliary disorders. However, surgical therapy and ERCP are not always easy to perform due to several contraindications. Because of difficulty in performing these procedures or unavailability of these procedures in the facility, PTBD, as the primary non-surgical procedure of choice, has been popular due to its easy technique. Endoscopic ultrasound (EUS) has evolved significantly not only as a diagnostic tool for identification and staging, but also for interventional approaches, especially in management of biliary malignancy. Recently, EUS-guided biliary drainage (EUS-BD) and EUS-guided gallbladder drainage (EUS-GBD) are developed for managing biliary disorders. Whether EUS can be useful for managing biliary obstruction as a primary procedure is still controversial. Hence, a large number of further studies are required to validate. © 2021, Japanese Society of Gastroenterology. |
Biliary obstruction; Endoscopic ultrasound (EUS); EUS-guided biliary drainage (EUS-BD); EUS-guided gallbladder drainage (EUS-GBD); Portal hypertension |
biliary tract disease; biliary tract drainage; cholestasis; endoscopic retrograde cholangiopancreatography; endoscopic ultrasonography; examination; gallbladder drainage; history of medicine; human; interventional ultrasonography; nonhuman; percutaneous transhepatic drainage; portal hypertension; Review; screening; biliary tract tumor; cholestasis; diagnostic imaging; endoscopic ultrasonography; Biliary Tract Neoplasms; Cholangiopancreatography, Endoscopic Retrograde; Cholestasis; Drainage; Endosonography; Humans |
Springer Japan |
18657257 |
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33895970 |
Review |
Q3 |
414 |
11779 |
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278 |
Saroyo Y.B., Harzif A.K., Anisa B.M., Charilda F.E. |
57164888400;57191493435;57195936232;57222329284; |
Thyroid storm in the second stage of labour: A case report |
2021 |
BMJ Case Reports |
14 |
7 |
e243159 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111078258&doi=10.1136%2fbcr-2021-243159&partnerID=40&md5=e3ec18b255c13bcad0e9401bfa44b499 |
Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
Saroyo, Y.B., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Harzif, A.K., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Anisa, B.M., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia; Charilda, F.E., Department of Obstetrics and Gynecology, Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo General Hospital, Jakarta Pusat, Indonesia |
A thyroid storm (or thyroid crisis) is an emergency in endocrinology. It is a form of complication of hyperthyroidism that can be life-threatening. Inadequate control of hyperthyroidism in pregnancy could develop into thyroid storm, especially in the peripartum period. We present a woman came in the second stage of labour, with thyroid storm, superimposed pre-eclampsia, acute lung oedema and impending respiratory failure. Treatment for thyroid storm, pre-eclampsia protocol and corticosteroid was delivered. The baby was born uneventfully, while the mother was discharged after 5 days of hospitalisation. Delivery is an important precipitant in the development of thyroid storm in uncontrolled hyperthyroidism in pregnancy. Although very rare, it can cause severe consequences. Diagnosis and treatment guidelines for thyroid storm were available and should be done aggressively and immediately. Uncontrolled hyperthyroidism should be prevented by adequate control in thyroid hormone levels, especially before the peripartum period. © |
endocrinology; obstetrics and gynaecology; thyroid disease |
alanine aminotransferase; aspartate aminotransferase; bicarbonate; corticosteroid; creatinine; dexamethasone; lactate dehydrogenase; lugol; magnesium sulfate; nifedipine; propranolol; propylthiouracil; thyroid hormone; thyrotropin; thyroxine; adult; alanine aminotransferase blood level; ambient air; amnion fluid; Apgar score; Article; aspartate aminotransferase blood level; auscultation; birth length; birth weight; bleeding; blood carbon dioxide tension; blood gas analysis; blood pressure; body temperature; breathing rate; case report; clinical article; clinical examination; clinical feature; consciousness level; continuous positive airway pressure; coronavirus disease 2019; creatinine blood level; diagnostic procedure; disease course; disease duration; disease severity; electrography; epi |
BMJ Publishing Group |
1757790X |
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34290023 |
Article |
Q4 |
231 |
17583 |
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299 |
SITOHANG I.B.S., ANWAR A.I., JUSUF N.K., ARIMUKO A., NORAWATI L., VERONICA S. |
56734569200;57205655192;57188840371;57222706279;57217009388;57217003979; |
Evaluating oral glutathione plus ascorbic acid, alpha-lipoic acid, and zinc aspartate as a skin-lightening agent: An indonesian multicenter, randomized, controlled trial |
2021 |
Journal of Clinical and Aesthetic Dermatology |
14 |
7 |
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E53 |
E58 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85113537297&partnerID=40&md5=f7d6f0bdd3408b798182f7ccc399f039 |
Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Dermatology and Venereology, Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara-Universitas Sumatera Utara Hospital, Medan, Indonesia; Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia |
SITOHANG, I.B.S., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Indonesia Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia; ANWAR, A.I., Department of Dermatology and Venereology, Faculty of Medicine Universitas Hasanuddin Dr. Wahidin Sudirohusodo Hospital, Makassar, Indonesia; JUSUF, N.K., Division of Cosmetic Dermatology, Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sumatera Utara-Universitas Sumatera Utara Hospital, Medan, Indonesia; ARIMUKO, A., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia; NORAWATI, L., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia; VERONICA, S., Department of Dermatology and Venereology, Presidential-Army Central Hospital Gatot Soebroto, Jakarta, Indonesia |
CLINICALTRIALS.GOV IDENTIFIER: NCT04105504. BACKGROUND: For Asians, especially women with darker skin tones (Fitzpatrick Skin Types IV and V), clear, bright skin is considered highly desirable, and various topical, oral, or injection-based cosmetic skin-lightening agents with different mechanisms of action are widely available across Asia. OBJECTIVE: We sought to investigate the effcacy and safety of an oral glutathione supplement comprising L-glutathione (fermentation), ascorbic acid, alpha-lipoic acid, and zinc (as zinc aspartate) as a skin-lightening agent. METHODS: This randomized, double-blind, controlled clinical trial was carried out at three teaching hospital-based dermatovenereology clinics in Indonesia. Participants were randomized to receive either the glutathione supplement or placebo capsules and were evaluated every four weeks over a 12-week study period. Total reduction in spot ultraviolet, spot polarization, and skin tone were measured and recorded using a Janus Facial Analysis System® (PIE Co., Ltd, Suwon-si, Gyeonggido, Korea). RESULTS: Eighty-three participants, aged between 33 and 50 years, completed the study. Reductions in spot ultraviolet in certain subgroups, spot polarization, and skin tone were greater in the glutathione supplement group than in the placebo group, but the difference was not statistically significant. Both the glutathione supplement and placebo groups experienced only mild side effects in the first four weeks. CONCLUSION: The oral glutathione supplement was slightly beneficial for skin lightening in particular subgroups, but the results were not statistically significant. Mild and temporary side effects were reported. Further research is required to more fully evaluate the effcacy of this glutathione supplement as a skin-lightening agent. © 2021 Matrix Medical Communications. All rights reserved. |
Glutathione plus; Skin tone; Skin-lightening agent; Spot polarization; Spot ultraviolet |
ascorbic acid; depigmenting agent; gelatin; glucose; glutathione; keratin; lynae mazthione; placebo; porphyrin; sunscreen; thioctic acid; zinc aspartate; acne; adult; Article; cheek; combination drug therapy; comedo; controlled clinical trial; controlled study; double blind procedure; drug capsule; drug efficacy; drug safety; epigastric pain; eye; female; follow up; forehead; human; Indonesia; major clinical study; melanogenesis; multicenter study; nausea; nose; outcome assessment; pigmentation; pruritus; randomized controlled trial; sebum; side effect; skin bump; skin disease; sun exposure; supplementation; teaching hospital; treatment duration; ultraviolet radiation; wrinkle |
Matrix Medical Communications |
19412789 |
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Article |
Q2 |
600 |
8425 |
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301 |
Utami P.D., Hadi U., Dachlan Y.P., Suryokusumo G., Loeki Enggar Fitri R., Yudo V. |
57221766908;55804160500;6602868510;57205444996;57226796443;57226798501; |
Protection against brain histopathological damage in experimental cerebral malaria models after exposure to hyperbaric oxigent |
2021 |
Research Journal of Pharmacy and Technology |
14 |
7 |
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3833 |
3838 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85112730263&doi=10.52711%2f0974-360X.2021.00665&partnerID=40&md5=1e7f971b7e62fc8286374b6c4e534dd9 |
Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
Utami, P.D., Department of Parasitology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia; Hadi, U., Department of Internal Medicine, Dr. Soetomo Hospital, Universitas Airlangga, Surabaya, Indonesia; Dachlan, Y.P., Department of Parasitology, Faculty of Medicine, Universitas Airlangga, Surabaya, Indonesia; Suryokusumo, G., Department of Occupational Health, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Loeki Enggar Fitri, R., Department of Parasitology, Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Yudo, V., Department of Microbiology, Faculty of Medicine, Hang Tuah University, Surabaya, Indonesia |
In this study, brain damage caused by cerebral malaria was induced by parasitized erythrocyte rupture and sequestration, which led to inflammation and blood vessel damage. Therefore, this research objective to determine the effect of oxygen administration on the histopathological features and sequestration of CD3 lymphocyte T cells on Plasmodium berghei ANKA/PbA-infected vascular endothelial brain tissue of mice. The study samples consisted of 39 C57BL/6 mice, which were divided into 3 groups: G1 contained normal mice; G2 contained PbA-infected mice; G3 were mice infected with PbA, and administered HBO 2.4 ATA for 10 days straight. Histopathological examination of the of brain tissue and CD3 lymphocyte T cell expression was carried out using immuno-histochemical at the end of the study. Therefore, the results of this study indicate that HBO administration can reduce the level of parasites, can improve the histopathological features of the brain, and can reduce the sequestration of CD3 cells in the brain's blood vessels. According to the results, it can be concluded that 10 sessions of HBO 2.4 ATA exposure can reduce the level of parasites, enhance the histopathological features of brain tissue and decrease the sequestration of CD3 lymphocyte T cells. © RJPT All right reserved. |
CD3 cells; Cerebral malaria; Endothel; Histopathological; Hyperbaric oxygen |
CD3 antigen; cytotoxic T lymphocyte antigen 4; ketamine; reactive oxygen metabolite; tumor necrosis factor; animal cell; animal experiment; animal model; animal tissue; Article; blood brain barrier; blood smear; blood vessel injury; brain damage; brain protection; brain tissue; CD4+ T lymphocyte; CD8+ T lymphocyte; cell adhesion; cerebral malaria; consciousness; controlled study; endothelium; endothelium cell; erythrocyte count; female; gene expression; hematological parameters; histochemistry; histopathology; hyperbaric oxygen therapy; immunohistochemistry; inflammation; leukocyte count; malaria; mortality rate; neutrophil lymphocyte ratio; nonhuman; oxygen therapy; parasitemia; phagocytosis; Plasmodium berghei ANKA; protein expression; T lymphocyte |
Research Journal of Pharmacy and Technology |
09743618 |
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Article |
Q3 |
225 |
17916 |
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304 |
Gunawan S., Aulia A., Soetikno V. |
57226331078;57201441066;36769252100; |
Development of rat metabolic syndrome models: A review |
2021 |
Veterinary World |
14 |
7 |
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1774 |
1783 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85111179239&doi=10.14202%2fvetworld.2021.1774-1783&partnerID=40&md5=609e64dbfe9d6c9660d991f611abbd71 |
Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia; Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Gunawan, S., Department of Pharmacology, Faculty of Medicine, Universitas Tarumanagara, Jakarta, Indonesia, Doctoral Programme in Biomedical Science, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Aulia, A., Department of Histology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Metabolic syndrome (MetS) has become a global problem. With the increasing prevalence of MetS worldwide, understanding its pathogenesis and treatment modalities are essential. Animal models should allow an appropriate representation of the clinical manifestations of human conditions. Rats are the most commonly used experimental animals for the study. The development of a proper MetS model using rats will contribute to the successful application of research findings to the clinical setting. Various intervention methods are used to induce MetS through diet induction with various compositions, chemicals, or a combination of both. This review will provide a comprehensive overview of several studies on the development of rat MetS models, along with the characteristics of the clinical manifestations resulting from each study. © 2021 Veterinary World. All rights reserved. |
High-fat diet; High-fructose diet; High-sucrose diet; Metabolic syndrome; Rat models |
cholesterol; diacylglycerol; glucose; high density lipoprotein cholesterol; leptin receptor; low density lipoprotein cholesterol; triacylglycerol; abdominal circumference; abdominal obesity; animal model; bipolar disorder; body weight; bone metabolism; caloric intake; carbohydrate intake; cardiovascular disease; diastolic blood pressure; dyslipidemia; exercise; fat mass; food intake; gene; glucose blood level; glucose tolerance; high-fructose diet; human; hyperglycemia; insulin resistance; insulin sensitivity; insulin tolerance test; lipid diet; lipid metabolism; lipid storage; lipogenesis; major depression; male; mental disease; metabolic syndrome X; nonalcoholic fatty liver; nonhuman; osmotic stress; oxidative stress; pathogenesis; physical activity; prevalence; rat; Review; risk factor; |
Veterinary World |
09728988 |
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Review |
Q2 |
550 |
9187 |
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