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629 |
Kartika R.W., Alwi I., Reksodiputro M.H., Yunir E., Waspadji S., Immanuel S., Silalahi T., Sungkar S., Rachmat J., Bardosono S., Suyatna F.D. |
57223447932;15055173800;35090488800;36520254800;8678136400;57272979000;56275255400;57016857300;6507225348;21933841000;56039633100; |
Combination of Hyaluronic Acid with Advance-Platelet Rich Fibrin to Reduce Chronic Inflammation: a study in IL-6 and Granulation Index |
2021 |
Jordan Journal of Biological Sciences |
14 |
5 |
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983 |
989 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123993135&doi=10.54319%2fJJBS%2f140516&partnerID=40&md5=b5a893eb952c904c665bb27f1cef51cb |
Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia; Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Kartika, R.W., Department of Surgery, Faculty of Medical and Health Science, Krida Wacana Christian University, Jakarta, Indonesia, Doctoral Program in Medical, Science Faculty of Medicine Universitas, Indonesia; Alwi, I., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Reksodiputro, M.H., Facial Plastic Reconstructive Division, Department of Otorhinolaryngology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Yunir, E., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Waspadji, S., Department of Internal Medicine, Faculty of Medicine Universitas Indonesia — Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Immanuel, S., Department of Clinical Pathology, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Silalahi, T., Department of Internal Medicine, Krida Wacana Christian University, Jakarta, Indonesia; Sungkar, S., Department of Clinical Parasitology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rachmat, J., Department of Thoracic Cardiac and Vascular Surgery, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suyatna, F.D., Department of Clinical Pharmacology, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
BACKGROUND: Type-2 Diabetes mellitus patients have risk of diabetic foot ulcers (DFUs) ranging from 15% to 25% with morbidity of 5% in the first 12 months, and the mortality rate at 5 years is around 42%. AIM: This research was conducted to study the novelty of a combining Hyaluronic Acid (HA) with Advanced Platelet Rich Fibrin (A-PRF) to reduce inflammation in DFUs healing through raising granulation index. METHODS: The study used a randomized control trial design, done from July 2019-March 2020 at Gatot Soebroto Army Hospital and Koja District Hospital, Jakarta. Subjects were DFU wound area < 40 cm2. At the start of the study all subjects received the same treatment, debridement and standard wound care. Twenty subjects were recruited according to the rule of thumb and were randomly divided into two groups namely topical A-PRF + HA (n = 10) and NaCl 0.9% (control) groups (n = 10). A part of the sample was processed into lysate and stored in -80oC. The rest is applied as a topical therapy in DFU base on intervention (A-PRF+HA or NaCl as a control). We analyzed the inflammation use swab sampling in DFU and analyze use ELISA on day- 3 and day-7. We also measured the wound area by a digital photograph and analyzed using ImageJ at the same time. RESULT: From this research, it was obtained 20 DFU subjects with Wagner 2 classification. We also performed analysis of IL-6 from swab topical DFU. A-PRF+HA group was significantly lower than NaCl (control) from swab DFU on day -3 (p = 0,,049) and day-7 (p = 0.041). In A-PRF+HA group affected on increase epithelialization process/ decrease wound area on day-3 (p = 0.016), day-7 (p = 0.048), and day-14 (p= 0.03 CONSLUSION: With the homogeneous gel formation of A-PRF + HA, it will accelerate the formation of granulation tissue compared to conventional NaCl therapy through reduce inflammation by decrease IL-6 levels. In addition, the combination A-PRF + HA has the effect of accelerating the formation of epithelialization shown by decreasing wound area in intervention group. © 2021 Jordan Journal of Biological Sciences. All Rights Reserved. |
Diabetic Foot Ulcer- Advanced Platetelet Rich Fibrin- Hyaluronic Acid-Granulation |
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Hashemite University |
19956673 |
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Article |
Q3 |
216 |
18398 |
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630 |
Indrasari M., Kusdhany L.S., Maharani D.A., Ismail R.I. |
57193349086;55301180900;32867911000;55996895500; |
Development of the Indonesian version of the Oral Health Impact Profile in Edentulous Prosthodontic Patients |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1531 |
1536 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123868913&partnerID=40&md5=29207b68d1256bd93f9c88f61071a0dd |
Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Indrasari, M., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Kusdhany, L.S., Prosthodontics Department of, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Maharani, D.A., Preventive and Public Health Dentistry Department, Faculty of Dentistry, Universitas Indonesia, Jakarta, 10430, Indonesia; Ismail, R.I., Psychiatrics Department, Faculty of Medicine, Universitas Indonesia, Jakarta, 10430, Indonesia |
Oral Health Impact Profile in Edentulous (OHIP-EDENT) is an instrument that measures several aspects of oral health-related quality of life as it relates to edentulous patients. Numerous studies have shown that edentulous has an impact on an individual's quality of life. This instrument aids in detecting the impact of oral health on the quality of life of patients who wear prostheses. The purpose of this study was to develop the OHIP-EDENT in Indonesian version for edentulous patients. The questionnaire was translated into Indonesian, back-translated, pre-tested, and crossculturally adapted. The qualitative interviews were carried out of 12 subjects, 46-77 years old, with diverse levels of formal education. All subjects were undergoing complete or single complete denture treatments at Dental Hospital Faculty of Dentistry, Universitas Indonesia, Jakarta, Indonesia. Since an expert committee agreed upon the original version, the questionnaire was translated, back-translated, and the outcomes of the qualitative interviews were used to finalize the revised instrument. After the pretesting, the adapted Indonesian OHIP-EDENT can be used as an instrument that is easy to use by edentulous patients undergoing complete or single denture treatments. Further analyses of the questionnaire's psychometric properties are needed to confirm its validity and reliability in target settings. © 2021,Journal of International Dental and Medical Research.All Rights Reserved |
Complete denture; Cross-cultural adaptation; Edentulous; Oral health; Quality oflife |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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631 |
Siahaan P.E.A., Kusumawardhani A.A.A.A., Ismail R.I., Malik K. |
57435237600;14633768700;55996895500;57204114533; |
Effectiveness of the "Emotion Recognition" Music Therapy Module in Schizophrenia Patients: A Quasi Experimental Study |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1722 |
1726 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123861310&partnerID=40&md5=d39caa1cc0263ce0e3e32f24151e3bb2 |
Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
Siahaan, P.E.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Kusumawardhani, A.A.A.A., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Ismail, R.I., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia; Malik, K., Departement of Psychiatry, Medical Faculty, University of Indonesia, Jakarta, Indonesia |
One of the deficit domains of social cognition in schizophrenia patients is emotion recognition. Negative emotion recognition deficits, such as emotional deficits of fear, anger, and sadness already exist in the first episode of schizophrenia. Music as therapy is known to be beneficial for emotional improvement, as well as the emotional experience of patients with schizophrenia. This study was aimed to assess the validity and effectiveness of a music therapy module “emotion recognition” in improving recognition of basic emotions in patients with schizophrenia. This quasi experimental study was conducted at the adult outpatient clinic at Cipto Mangunkusumo Hospital. The research was conducted in 2 steps. The first step to assess the validity of the module by calculate the I-CVI, S-CVI, and CVR of validity test and the second step to implement the music therapy module to the patient. This study assessed 15 subjects of schizophrenic remission patients who attended music therapy for 10 sessions conducted from March 2020 to July 2020. Subjects were assessed pre and post music therapy test results to see the effectivity of the module as seen by improvements in recognition of 5 basic emotions (happy, sad, anger, fear, tender) using the Mcnemar statistical test. The results of the validity test of the module showed the I-CVI of 0.98, S-CVI of 0.95, and CVR of 0.97. There was a significant improvement in the emotional deficits of fear and anger, with an increase in the pre and post music therapy test scores with a p-value 0.016 in the anger emotion and 0.008 in fear emotion, but not significant in the happy, sad, and tender emotions (p-value> 0.05). The emotion recognition music therapy module has good content validity, and effectiveness in emotion recognition of some of the basic emotions of remission schizophrenia patients, especially the emotion recognition of fear and anger. © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Effectivity; Emotion recognition; Music therapy; Schizophrenia |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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632 |
Arozal W., Barinda A.J., Monayo E.R., Aulia R. |
32067462200;57196373933;56955565900;56955797500; |
Mangiferin Attenuates Doxorubicin-Induced Nephrotoxicity in Rats Through Reduction of Oxidative Stress |
2021 |
Journal of International Dental and Medical Research |
14 |
4 |
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1667 |
1674 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123841744&partnerID=40&md5=1da2ad818beb007235cddc77a1b487fe |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Arozal, W., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Barinda, A.J., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Monayo, E.R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia; Aulia, R., Magister Program Biomedical Science, Faculty of Medicine, Universitas Indonesia, Salemba Raya 6, Jakarta, 10430, Indonesia |
Doxorubicin (DOX) has been widely used in the clinical setting for malignancy treatment.However, it also induces toxicity in a vital organ such as the kidney. Several studies suggest theformation of an iron anthracycline complex which produces free radicals plays an important role innephrotoxicity.Mangiferin (MGF), a xanthone derivate, exhibits as an iron chelator and antioxidant activitythrough a free radical scavenger activity. We analyzed the effect of MGF to prevent DOX inducednephrotoxicity. Male Sprague-Dawley rats were administered MGF orally every day for five weeks,with 50 and 100 mg/kg BW together with DOX. Renal failure and dyslipidemia were detected in theDOX groups in association with increased malondialdehyde (MDA) levels in plasma and kidney anddecreased superoxide dismutase (SOD) and glutathione (GSH) levels in kidney. Of note, cotreatmentwith MGF improved renal dysfunction caused by doxorubicin as shown by theamelioration plasma albumin, urea and creatinine levels, and proteinuria. MGF also diminishedover-production of MDA levels, thus enhanced antioxidant activity such as SOD and GSH in thekidney.Our study opens the perspective to clinical studies for consideration of MGF as a potentialchemoprotectant nutraceutical in the combination chemotherapy with DOX to limit its nephrotoxicity © 2021, Journal of International Dental and Medical Research. All Rights Reserved. |
Doxorubicin; Kidney; Mangiferin; Toxicity |
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University of Dicle |
1309100X |
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Article |
Q3 |
259 |
16312 |
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635 |
Rahayu G.R., Findyartini A., Riskiyana R., Thadeus M.S., Meidianawaty V., Sari S.M., Puspadewi N., Bekti R.S., Hermasari B.K., Sudarso S., Utami A.E., Kusumawati W. |
56357905400;56543777300;57201674808;57226238484;57205473406;57428214600;57215214003;57195687179;57211539313;57195505857;57427895500;57160948400; |
Stakeholders’ Views and Confidence Towards Indonesian Medical Doctor National Competency Examination: A Qualitative Study |
2021 |
Journal of Multidisciplinary Healthcare |
14 |
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3411 |
3420 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85123507676&doi=10.2147%2fJMDH.S336965&partnerID=40&md5=95b31f286039f9e750174fa41df7c1f1 |
Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Rahayu, G.R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Findyartini, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Riskiyana, R., Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada, Yogyakarta, Indonesia; Thadeus, M.S., Faculty of Medicine, Universitas Pembangunan Nasional Veteran Jakarta, Jakarta, Indonesia; Meidianawaty, V., Faculty of Medicine, Universitas Swadaya Gunung Jati, Cirebon, Indonesia; Sari, S.M., Faculty of Medicine, Universitas Jenderal Achmad Yani, Cimahi, Indonesia; Puspadewi, N., School of Medicine and Health Sciences, Atma Jaya Catholic University of Indonesia, Jakarta, Indonesia; Bekti, R.S., Faculty of Medicine, Universitas Brawijaya, Malang, Indonesia; Hermasari, B.K., Faculty of Medicine, Universitas Sebelas Maret, Surakarta, Indonesia; Sudarso, S., Faculty of Medicine, Universitas Mulawarman, Samarinda, Indonesia; Utami, A.E., Ministry of Research, Technology, and Higher Education, Jakarta, Indonesia; Kusumawati, W., Faculty of Medicine and Health Science, Universitas Muhammadiyah Yogyakarta, Yogyakarta, Indonesia |
Introduction: Indonesia is a huge country consisting of 33 provinces with different characteristics. There are 83 medical schools across Indonesia with different accreditation statuses. The Indonesia Medical Doctor National Competency Examination (IMDNCE) has been established to control the quality of medical school graduates. The implementation of IMDNCE needed to be evaluated to determine its impact. To date, there has not been any research in Indonesia that explores the stakeholders’ perceptions toward IMDNCE. This study aimed to explore how the stakeholders in Indonesia perceived the impact of IMDNCE towards performances of medical school graduates in clinical practice. Methods and Study Participants: A qualitative study with phenomenological approach was conducted to investigate perceptions of stakeholders including representatives from consumer organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, employers (hospital and health center directors), clinical supervisors as well as patients across Indonesia. Data were obtained through focus group discussions (FGDs) and interviews. The study used thematic analysis methods to obtain the results. Results: A total of 90 study participants participated in the study including 10 representatives of consumer watchdog organizations, the National Health Coverage, the Ministry of Health, the Indonesian Medical Association, 31 employers, 32 professionals, and 17 patients. The study found three general themes which represent the perceptions of the stakeholders towards performances of medical school graduates in clinical practice: IMDNCE as an effort to standardize doctor graduates in Indonesia, the results of IMDNCE as a mean to reflect the quality of medical education in Indonesia, and IMDNCE as an effort to improve health services in Indonesia through the quality of graduates. Conclusion: In general, the stakeholders perceived that the IMDNCE was able to standardize medical school graduates from various medical schools across Indonesia. However, the IMDNCE needs to be further developed to maximize its potential in improving the competences of Indonesian medical students. © 2021 Rahayu et al. |
Medical education; Medical school graduates; National competency examination; Stakeholder view |
adult; article; clinical practice; consumer organization; employer; female; guard dog; health center; human; Indonesia; interview; major clinical study; male; medical education; medical school; medical society; medical student; nonhuman; perception; physician; public health; qualitative research; thematic analysis |
Dove Medical Press Ltd |
11782390 |
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Article |
Q1 |
650 |
7731 |
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637 |
Tjoa K., Kusmardi K., Midoen Y.H. |
57222366705;56966625300;57197805109; |
Effects of Industrial Waste Fish Oil Administration on Interleukin-6 (Il-6) Expression at Mice Colon being Induced by Azoxymethane (AOM) and Dextran Sodium Sulphate (DSS) |
2021 |
Biomedical and Pharmacology Journal |
14 |
4 |
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2227 |
2233 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85122824976&doi=10.13005%2fbpj%2f2321&partnerID=40&md5=bc79b4fdfe0aaabc3c89256150a440fb |
Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tjoa, K., Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Kusmardi, K., Departement of Anatomic Pathology, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Drug Development Research Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia, Human Cancer Research Center, Indonesian Medical Education and Research Institute, Faculty of Medicine, Universitas Indonesia, Jl Salemba Raya No 6, Senen, Jakarta, 10430, Indonesia; Midoen, Y.H., Departement of Medical Biology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Colorectal cancer (CRC) is the world's third most cancer and the second highest mortality rate. The searching for new anti-inflammation substances with less adverse effects than aspirin for chemoprevention and adjuvant chemotherapy of CRC is running. The most notable one is fish oil containing omega 3. Kusmardi, et al. studied that industrial waste fish oil omega-3 level comes close enough to conventional fish oil industry. Study aims to reducing the level IL-6 on mice colon tissue being induced CRC using AOM/DSS by fish oil administration. Thirty male Swiss Webster mice are grouped into six treatments: Positive control (aspirin), negative control (physiological saline), normal, high dose (fish oil 6mg/kgBW), medium dose (fish oil 3mg/kgBW), dan solvent control (corn oil). Colon tissue was stained using anti IL-6 antibody. Ten photos per slide were taken by microscope (400x), analyzed for the IL-6 expression by ImageJ®, and quantified for H-score. Data was analyzed using SPSS 24.0 (CI 95%) and p-value <0.05 is consider significant. Data are not normally distributed with median of 161.64 (119.4-260.67). Kruskal-Wallis test is significant in addition with Mann-Whitney test shows only high dose group has significant difference to negative control (p=0.008), medium dose (p=0.016) dan and solvent control (p=0.008). No significant difference reported between high dose and positive control group (p=0.69). High dose industrial waste fish oil can lower IL-6 expression in mice colon tissue induced CRC using AOM/DSS. © 2021 Oriental Scientific Publishing Company. |
Colitis Associated Cancer; Colorectal cancer; Interleukin-6; Omega-3 Fish Oil |
acetylsalicylic acid; CD34 antigen; cytochrome P450 2E1; fish oil; interleukin 6; microRNA; nonsteroid antiinflammatory agent; octamer transcription factor 4; probiotic agent; adjuvant chemotherapy; animal experiment; animal model; animal tissue; antiinflammatory activity; Article; azoxymethane-induced colon carcinogenesis; carcinogenesis; cardiovascular disease; cell proliferation; chemoprophylaxis; colon cancer; colon tissue; colorectal cancer; controlled study; dextran sulfate sodium-induced colitis; DNA methylation; drug megadose; fat intake; genomic instability; histone modification; immunohistochemistry; industrial waste; male; mortality rate; mouse; nonhuman; obesity; peritoneum adhesion; protein expression; quantitative analysis; rheumatoid arthritis; ulcerative colitis |
Oriental Scientific Publishing Company |
09746242 |
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Article |
Q4 |
191 |
19920 |
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653 |
Atmakusuma T.D., Saragih E.Y.P., Rajabto W. |
57216961785;57366253000;36519576100; |
Achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta thalassemia: Associated factors and relationship to reduction of spleen enlargement |
2021 |
International Journal of General Medicine |
14 |
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7515 |
7521 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85120785623&doi=10.2147%2fIJGM.S338114&partnerID=40&md5=2c1002de475a8646609051daf96840ae |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Tangerang Regional Public Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Saragih, E.Y.P., Division of Hematology-Medical Oncology, Department of Internal Medicine, Tangerang Regional Public Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rajabto, W., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: The achievement of blood transfusion hemoglobin targets in transfusiondependent beta-thalassemia patients is influenced by several factors such as genotype, hypersplenism, blood compatibility, donor blood adequacy, and transfusion interval. Failure to achieve these targets leads to an increase in the size of the spleen. Meanwhile, the post-transfusion hemoglobin of thalassemia patients that is not regularly evaluated has made it difficult to determine donor adequacy. Therefore, this study aims to determine the proportion of patients who achieve optimal pre-and post-transfusion hemoglobin levels, determine the factors involved, and the relationship between achieving hemoglobin levels with spleen enlargement in adult transfusion-dependent betathalassemia patients. Methods: This retrospective cohort study was conducted using total sampling of adult thalassemia transfusion-dependent patients at Cipto Mangunkusumo Hospital. Data were obtained through medical records. Results: A hundred and ten study subjects fulfilled inclusion criteria. The results showed that the blood transfusion deficit <30 mL/kg/year was associated with achieving pre-and post-transfusion hemoglobin targets (p = 0.008). Furthermore, there were significant differences between the groups that achieved the pre-and post-transfusion target hemoglobin levels on the reduction of spleen enlargement in centimeters (p < 0.001). However, thalassemia genotype, blood compatibility, and transfusion interval did not correlate with the achievement of pre-and post-transfusion hemoglobin. Conclusion: The achievement of pre-and post-transfusion hemoglobin levels in adult transfusion-dependent beta-thalassemia patients significantly reduced spleen enlargement and contributed to better patient outcomes. © 2021 Atmakusuma et al. This work is published and licensed by Dove Medical Press Limited. |
Risk factors; Spleen enlargement; Target hemoglobin level; Transfusion-dependent beta-thalassemia |
hemoglobin; adult; Article; beta thalassemia; blood compatibility; blood transfusion; cohort analysis; correlation analysis; educational status; employment status; female; genotype; hemoglobin blood level; human; hypersplenism; Indonesia; leukopenia; major clinical study; male; medical record review; retrospective study; spleen size; splenomegaly; thrombocytopenia; treatment outcome; young adult |
Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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665 |
Atmakusuma T.D., Nasution I.R., Sutandyo N. |
57216961785;8259214700;26028099200; |
Oxidative stress (Malondialdehyde) in adults beta-thalassemia major and intermedia: Comparison between before and after blood transfusion and its correlation with iron overload |
2021 |
International Journal of General Medicine |
14 |
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6455 |
6462 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85119614825&doi=10.2147%2fIJGM.S336805&partnerID=40&md5=31da8ca15b655debd14557088a36df4a |
Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Gatot Soebroto Army Hospital Jakarta/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology-Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital Jakarta/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Atmakusuma, T.D., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Nasution, I.R., Division of Hematology-Medical Oncology, Department of Internal Medicine, Gatot Soebroto Army Hospital Jakarta/Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sutandyo, N., Division of Hematology-Medical Oncology, Department of Internal Medicine, Dharmais National Cancer Hospital Jakarta/Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Background: Iron overload is a major problem in both transfusion-dependent (TDT) and non-transfusion-dependent thalassemia (NTDT). It has been known to increase oxidative stress. Meanwhile, blood transfusion as main therapy for thalassemia increases iron overload. One of the markers of oxidative stress is malondialdehyde (MDA). This study aims to provide data on MDA levels in adult thalassemia patients, and to compare the levels before and after transfusion in patients with TDT and NTDT. Methods: This is a cross-sectional, pre-post study in adult patients with thalassemia major and intermedia that received blood transfusion with or without iron-chelating agents in Cipto Mangunkusumo Hospital. Blood samples were taken immediately before the transfusion and one day after. Serum ferritin (SF) assays were conducted by electrochemiluminescence immunoassay method, while transferrin saturation (TS) was calculated by dividing serum iron by the binding capacity. Subsequently, plasma MDA levels assays were performed using the Wills method, and data analysis was conducted using the t-test/Mann–Whitney and Pearson/Spearman correlation test, depending on the data distribution. Results: The 63 respondents recruited consist of 51 TDT and 12 NTDT patients, and their median plasma MDA level before and after transfusion was 0.49 µmol/L and 0.45 µmol/L, respectively. Before transfusion, there was no correlation between SF and MDA, and TS and MDA levels. After the transfusion, there was no correlation between, SF and MDA, or TS and MDA levels. Conclusion: There is no significant difference in MDA levels before and after transfusion. Although blood transfusion increases the iron load in thalassemia patients, there was no increase in median MDA level after transfusion. Meanwhile, there was no correlation between markers of iron overload and MDA level in thalassemia patients both before and after transfusion. © 2021 Atmakusuma et al. This work is published and licensed by Dove Medical Press Limited. |
Iron overload; Malondialdehyde; Non-transfusion dependent thalassemia; Oxidative stress; Transfusion-dependent thalassemia |
deferasirox; deferiprone; deferoxamine; ferritin; malonaldehyde; adult; aged; Article; blood transfusion; controlled study; cross-sectional study; female; ferritin blood level; hemoglobin E-beta thalassemia; human; Indonesia; iron chelation; iron overload; major clinical study; male; non transfusion dependent thalassemia; oxidative stress; thalassemia major; transferrin saturation; transfusion dependent thalassemia |
Dove Medical Press Ltd |
11787074 |
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722 |
6874 |
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677 |
Vandenplas Y., Brough H.A., Fiocchi A., Miqdady M., Munasir Z., Salvatore S., Thapar N., Venter C., Vieira M.C., Meyer R. |
57223670656;37064383600;7006595735;26664817800;7801694370;55390678300;8337607800;35944268900;8270521000;7404078956; |
Current guidelines and future strategies for the management of cow’s milk allergy |
2021 |
Journal of Asthma and Allergy |
14 |
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1244 |
1256 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85118723222&doi=10.2147%2fJAA.S276992&partnerID=40&md5=2b3b3cbc9500f0760551157f099bf4c4 |
Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Brussels, Belgium; Department Women and Children’s Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom; Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom; Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St, Thomas’s NHS Foundation Trust, London, United Kingdom; Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children’s Hospital, IRCCS, Piazza Sant’Onofrio, Rome, Italy; Department of Pediatrics, Sheikh Khalifa Medical City, College of Medicine & Health Sciences, Khalifa University, Khalifa, United Arab Emirates; Department of Child Health, Ciptomangunkusumo Hospital-Medical Faculty Universitas Indonesia, Jakarta, Indonesia; Pediatric Department, Hospital “F. Del Ponte”, University of Insubria, Varese, Italy; Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, Brisbane, QLD, Australia; University of Colorado, Children’s Hospital Colorado, Denver, CO, United States; Center for Pediatric Gastroenterology-Hospital Pequeno Príncipe, Curitiba, Brazil; Department of Paediatrics, Imperial College, London, United Kingdom; Department Nutrition and Dietetics, University of Winchester, Winchester, United Kingdom |
Vandenplas, Y., Vrije Universiteit Brussel (VUB), UZ Brussel, KidZ Health Castle, Brussels, Belgium; Brough, H.A., Department Women and Children’s Health (Pediatric Allergy), School of Life Course Sciences, Faculty of Life Sciences and Medicine, King’s College London, London, United Kingdom, Peter Gorer Department of Immunobiology, School of Immunology and Microbial Sciences, King’s College London, London, United Kingdom, Children’s Allergy Service, Evelina Children’s Hospital, Guy’s and St, Thomas’s NHS Foundation Trust, London, United Kingdom; Fiocchi, A., Translational Research in Pediatric Specialities Area, Division of Allergy, Bambino Gesù Children’s Hospital, IRCCS, Piazza Sant’Onofrio, Rome, Italy; Miqdady, M., Department of Pediatrics, Sheikh Khalifa Medical City, College of Medicine & Health Sciences, Khalifa University, Khalifa, United Arab Emirates; Munasir, Z., Department of Child Health, Ciptomangunkusumo Hospital-Medical Faculty Universitas Indonesia, Jakarta, Indonesia; Salvatore, S., Pediatric Department, Hospital “F. Del Ponte”, University of Insubria, Varese, Italy; Thapar, N., Gastroenterology, Hepatology and Liver Transplant, Queensland Children’s Hospital, Brisbane, QLD, Australia; Venter, C., University of Colorado, Children’s Hospital Colorado, Denver, CO, United States; Vieira, M.C., Center for Pediatric Gastroenterology-Hospital Pequeno Príncipe, Curitiba, Brazil; Meyer, R., Department of Paediatrics, Imperial College, London, United Kingdom, Department Nutrition and Dietetics, University of Winchester, Winchester, United Kingdom |
Exclusive breast feeding is recommended in all guidelines as the first choice feeding. Cow milk allergy (CMA) can be diagnosed by a diagnostic elimination diet for 2 to 4 weeks with a hypo-allergenic formula, followed by a challenge test with intact cow milk protein. The most often used hypo-allergenic formula for the diagnostic elimination diet and the therapeutic diet is a CM based extensive hydrolysate. CM-based partial hydrolysates cannot be recommended in the management of CMA because of insufficient efficacy and possible reactions, but about half of the infants with CMA may tolerate a partial hydrolysate. The pros and cons of other dietary options are discussed in this paper. The use of an amino acid-based formula and/or rice based hydrolysate formula during the diagnostic elimination and therapeutic diet is debated. When available, there is sufficient evidence to consider rice hydrolysates as an adequate alternative to CM-based hydrolysates, since some infants will still react to the CM hydrolysate. The pros and cons of dietary options such as soy formula, buckwheat, almond, pea or other plant based dietary products are discussed. Although the majority of the plant-based beverages are nutritionally inadequate, some are nutritionally adapted for toddlers. However, accessibility and content vary by country and, thus far there is insufficient evidence on the efficacy and tolerance of these plant-based drinks (except for soy formula and rice hydrolysates) to provide an opinion on them. Conclusion: A diagnostic elimination diet, followed by a challenge remains the diagnostic standard. The use of an awareness tool may result in a decrease of delayed diagnosis. Breastmilk remains the ideal source of nutrition and when not available a CM extensively hydrolyzed formula, rice hydrolysate or amino acid formula should be recommended. More evidence is needed regarding plant-based drinks. © 2021 Vandenplas et al. |
Amino acid formula; Challenge test; Cow milk allergy; Hydrolysate; Plant-based drink; Rice hydrolysate; Soy formula |
alpha 1 antitrypsin; amino acid based formula; beta defensin; beta lactoglobulin; calcium; calgranulin; casein hydrolysate; cyanocobalamin; folic acid; food allergen; immunoglobulin A; immunoglobulin E; immunoglobulin G4; iodine; partial hydrolysate formula; prebiotic agent; probiotic agent; short chain fatty acid; soybean protein; tumor necrosis factor; unclassified drug; vitamin; allergenicity; almond; asthma; awareness; beverage; Bifidobacteriaceae; breast feeding; buckwheat; buffalo milk; camel milk; child growth; Clinical awareness score; colic; cow milk; Cow’s Milk related Symptom Score; dietary compliance; dietary fiber; donkey milk; double blind procedure; eczema; elimination diet; eosinophilic esophagitis; evidence based practice; facial angioedema; food intake; futurology; health |
Dove Medical Press Ltd |
11786965 |
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Review |
Q1 |
1162 |
3475 |
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684 |
Sukrisman L., Sinto R., Priantono D. |
8661764000;36099377100;57219443427; |
Hematologic profiles and correlation between absolute lymphocyte count and neutrophil/ lymphocyte ratio with markers of inflammation of covid-19 in an indonesian national referral hospital |
2021 |
International Journal of General Medicine |
14 |
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6919 |
6924 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117751905&doi=10.2147%2fIJGM.S337440&partnerID=40&md5=3dd70fba2ee4c7395a09b7807a9e5c42 |
Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Sukrisman, L., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Sinto, R., Division of Tropical and Infectious Disease, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Priantono, D., Division of Haematology-Medical Oncology, Department of Internal Medicine, Dr. Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Introduction: COVID-19 is a pandemic with significant mortality and it is important to differentiate severe and non-severe cases. We conducted a study to evaluate hematologic profiles with inflammation markers in COVID-19 patients and to determine the correlation of neutrophil-lymphocyte ratio (NLR) with disease severity. Methods: A cross-sectional study involving hospitalized COVID-19 patients confirmed with a positive SARS-CoV-2 PCR test in Dr. Cipto Mangunkusumo Hospital. Lymphocyte count, NLR, C-reactive protein (CRP) and ferritin were evaluated in severe and non-severe COVID-19 cases at hospital admission. Data was analyzed using Spearman correlation. Results: There were 41 patients aged 20 to 79 years with COVID-19; 33 (80.5%) were nonsevere, and 8 (19.5%) were severe cases. There is a statistically significant difference in WBC, relative neutrophils and lymphocytes, NLR, and CRP between non-severe and severe cases. There is a strong correlation between NLR and CRP (r = 0.738; p < 0.001). Our findings show that NLR and absolute lymphocyte count, but not ferritin, play a role in differentiating between non-severe and severe COVID-19 cases. Conclusion: In COVID-19 cases, a strong correlation between NLR and CRP might suggest the use of NLR to differentiate between non-severe and severe cases, especially in a remote healthcare facility. © 2021 Sukrisman et al. This work is published and licensed by Dove Medical Press Limited. |
COVID-19; Hematologic profiles; Inflammation; Lymphocyte; NLR |
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Dove Medical Press Ltd |
11787074 |
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Article |
Q2 |
722 |
6874 |
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