No records
|
817 |
Kusumawardani A., Yanfaunnas A.M., Supandi D.P., Inggita R.A.M., Andayani N.G.A.A.P.T., Louisa M., Soetikno V., Burhan E. |
57223083920;57223095441;57222624055;57223087394;57223088955;41461551400;36769252100;36058554600; |
The use of Urinary Lipoarabinomannan (LAM) as a Rapid Diagnostic Test for Adult Pulmonary Tuberculosis in HIV-Positive Patients: An Evidence-based Case Report |
2021 |
Journal of International Dental and Medical Research |
14 |
1 |
|
461 |
466 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104790784&partnerID=40&md5=012c79128a2fc69230627fe766651487 |
Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia |
Kusumawardani, A., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Yanfaunnas, A.M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Supandi, D.P., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Inggita, R.A.M., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Andayani, N.G.A.A.P.T., Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soetikno, V., Department of Pharmacology and Therapeutics, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Burhan, E., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine Universitas Indonesia/Persahabatan Hospital, Jakarta, Indonesia |
Tuberculosis is a major health concerns around the world as it is causing morbidity and mortality, especially in HIV infected patients. Detection of lipoarabinomannan (LAM) on urine is a non-sputum-based diagnostic test for TB that could accelerate TB case detection in HIV-positive patients. This evidence-based case report was aimed to evaluate the diagnostic value of urinary Lipoarabinomannan (LAM) test in diagnosing pulmonary tuberculosis in HIV-positive patients as compared to sputum culture. Structured literature searching was done on cross-sectional or systematic reviews of diagnostic studies of lipoarabinomannan versus sputum culture in adult HIV-positive patients suspected with pulmonary TB. There were 9 articles that meet the eligibility criteria; 1 systematic review and 8 cross-sectional studies. Two out of nine articles were deemed as not valid due to not using sputum on all samples and the index test and reference test were not carried out on all samples. There were contradictory results regarding the sensitivity, positive predictive values and negative predictive values, meanwhile the specificity showed good results. We conclude that urinary LAM can be used to diagnose pulmonary TB in HIV-positive patients due to its high specificity. However, it could not be used as a stand-alone test, due to its suboptimal sensitivity. © 2021 |
Sputum culture; TB-HIV; tuberculosis; urinary lipoarabinomannan |
|
University of Dicle |
1309100X |
|
|
Article |
Q3 |
259 |
16312 |
|
|
826 |
Irawati Y., Soedarman S., Arianti A., Widyasari A., Reksodiputro M.H. |
57201260313;57222867991;57201999421;57280734100;35090488800; |
Multiple approaches for managing complex ophthalmic blunt trauma: A case report |
2021 |
International Medical Case Reports Journal |
14 |
|
|
205 |
210 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104124100&doi=10.2147%2fIMCRJ.S304193&partnerID=40&md5=1d5a9d9b836b19267fc2e128d84efc72 |
Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Irawati, Y., Division of Plastic and Reconstructive Surgery, Department of Ophthalmology, Dr. Cipto Mangunkusumo Hospital, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia, Orbital and Oculoplastic Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Soedarman, S., Vitreo- Retina Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Arianti, A., Neuro- Ophthalmology Service, JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Widyasari, A., JEC Eye Hospitals and Clinics, Jakarta, Indonesia; Reksodiputro, M.H., Division of Plastic Reconstruction, Department of Ear, Nose and Throat, Dr. Cipto Mangunkusumo Hospital, Jakarta, Indonesia |
Introduction: Ophthalmic trauma is defined as injuries affecting the ocular structures, including the globe, eyelid, lacrimal system, and surrounding orbital walls. Blunt trauma acts as the leading cause of injury and it may affect both the anterior and posterior parts of the globe. Prompt diagnosis, early management, and sustained follow-up are mandatory for an optimal outcome. Purpose: This report presents a one-step surgery management process for an intricate case of blunt facial trauma with complex ophthalmic and nasal injury. Patients and Methods: A 45-year-old male with blunt force trauma of the left eye from a wooden block, suffered from naso-orbital-ethmoidal fractures, eyelid laceration with canalicular, close-globe injuries of traumatic cataract and vitreous hemorrhage with retinal detachment. A simultaneous one-step surgery was performed by a trauma team of ophthalmological and ENT surgeons during the height of the COVID-19 pandemic to lessen the risk of cross-transmission. After ruling out the possibility of open-globe rupture, traumatic cataract extraction, retinal detachment surgery, the repair of an eyelid laceration with canalicular involvement, and septorhinoplasty were performed on concomitantly. Results: Anatomical success was achieved for the repair of the nasoorbitoethmoidal (NOE) type II fracture and close-globe injuries, including the anatomical reattachment of the retina. However, the functional outcome remained unsatisfactory. Visual acuity failed to show further improvement at a later follow-up. Traumatic optic neuropathy was, at the final follow-up, considered to be the cause of the suboptimal visual acuity. Conclusion: A single-step multi-procedure for a complex ophthalmic blunt trauma, as demonstrated in this case, may be beneficial for reducing the complications that might arise due to treatment delay. The complex nature of the injury, however, creates the higher possibility for residual post-operative complications. Risks of residual functional impairment should be considered in such complex trauma prior to surgery, to determine the surgical prognostic value and provide appropriate consent to the patient. © 2021 Irawati et al. |
Blunt trauma; Canalicular laceration; Closed-globe injury; Facial injury; Nasal fracture; Ocular trauma |
adult; Article; blunt trauma; case report; cataract; clinical article; clinical examination; conjunctival hemorrhage; crackle; epistaxis; ethmoid bone; eye injury; eyelid closure; eyelid disease; eyelid reconstruction; face fracture; human; hyphema; Indonesia; laceration; lens implantation; male; middle aged; nasopharyngeal swab; nose injury; nose septum reconstruction; occupational accident; orbit fracture; postoperative care; retina detachment; ultrasound; visual acuity; vitrectomy; vitreous hemorrhage |
Dove Medical Press Ltd |
1179142X |
|
|
Article |
Q4 |
198 |
19482 |
|
|
839 |
Ayuandari S., Khasanah N., Riyanti I., Dewanto A., Enisar Sangun D., Wiweko B. |
56231262400;57222708996;57222710738;57190580042;57222709491;43061741400; |
Current awareness and attitude toward fertility preservation in Indonesia: A nationwide survey among health-care providers |
2021 |
Journal of Human Reproductive Sciences |
14 |
1 |
|
81 |
86 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103760305&doi=10.4103%2fjhrs.jhrs_239_20&partnerID=40&md5=10c9f18d628ded6d4e5658e52f96eb59 |
Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Ayuandari, S., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Khasanah, N., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Riyanti, I., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Dewanto, A., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Enisar Sangun, D., Department of Obstetrics and Gynaecology, Faculty of Medicine, Public Health and Nursing-Dr. Sardjito General Hospital, Universitas Gadjah Mada, Yogyakarta, Indonesia; Wiweko, B., Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology and Infertility, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Yasmin Ivf Clinic, Dr. Cipto Mangunkusumo General Hospital, Hum. Repro., Infertility and Fam. Plan. Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia, Indonesia Medical Education and Research Institute, Universitas Indonesia, Jakarta, Indonesia |
Context: Fertility preservation (FP) is necessary for cancer patients who develop infertility due to chemotherapy and radiotherapy. In Indonesia, many systematic steps and long-Term continued actions must be taken to establish FP units since there has been an increasing incidence of cancer among people under 45 years old. Aims: This study aimed at a comprehensive evaluation on the awareness and practices of health-care providers (HCPs) toward FP. Settings and Design: This was a descriptive cross-sectional study. Subjects and Methods: A validated nationwide online survey was completed by 160 HCPs as a representative sample from 11 provinces in 2017 that provide medical care to cancer patients at hospitals or clinics. Statistical Analysis Used: Descriptive statistics, analysis of variance, logistic regression, and Pearson correlation tests were used for the statistical analysis. Results: Respondents were specialists (59.4%) and other HCPs (40.6%). Around 60% of the HCPs who performed cancer therapies already discussed the fertility issues with their patients. Meanwhile, the HCPs (60.7%) also tended not to consult and refer their patients to fertility experts (P < 0.05). However, those who discussed the risk of infertility with patients tended to consult with and refer them to a fertility consultant for further FP procedure as the follow-up for their discussions (odds ratio = 8.98, confidence interval 95%, P < 0.05). Conclusions: In Indonesia, FP awareness of the HCPs who performed cancer therapy was high. Nevertheless, attitudes to refer patients to fertility experts for possible FP management still need to be improved. © 2021 Wolters Kluwer Medknow Publications. All rights reserved. |
Attitude; awareness; fertility preservation; health-care providers |
adult; analysis of variance; article; awareness; cancer patient; cancer therapy; controlled study; cross-sectional study; female; fertility preservation; fertility specialist; follow up; health survey; human; human tissue; Indonesia; male; medical care; risk assessment |
Wolters Kluwer Medknow Publications |
09741208 |
|
|
Article |
Q3 |
484 |
10359 |
|
|
847 |
Atmosudigdo I.S., Lim M.A., Radi B., Henrina J., Yonas E., Vania R., Pranata R. |
57222578186;57216039756;6603494019;57218482646;57201987097;57208328436;57201973901; |
Dyslipidemia Increases the Risk of Severe COVID-19: A Systematic Review, Meta-analysis, and Meta-regression |
2021 |
Clinical Medicine Insights: Endocrinology and Diabetes |
14 |
|
|
|
|
|
4 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103239096&doi=10.1177%2f1179551421990675&partnerID=40&md5=f2529886c6cb74cf353635e1abd100c3 |
Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Balaraja General Hospital, Tangerang, Indonesia; Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia |
Atmosudigdo, I.S., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Lim, M.A., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia; Radi, B., Department of Cardiology and Vascular Medicine, Faculty of Medicine Universitas Indonesia, National Cardiovascular Center Harapan Kita, Jakarta, Indonesia; Henrina, J., Balaraja General Hospital, Tangerang, Indonesia; Yonas, E., Faculty of Medicine, Universitas YARSI, Jakarta, Indonesia; Vania, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia, Division of Plastic, Reconstructive and Aesthetic, Department of Surgery, Faculty of Medicine, Sanglah General Hospital, Udayana University, Bali, Indonesia; Pranata, R., Faculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia |
Objective: This systematic review and meta-analysis aimed to evaluate whether dyslipidemia affects the mortality and severity of COVID-19, we also aimed to evaluate whether other comorbidities influence the association. Methods: A systematic literature search using PubMed, Embase, and EuropePMC was performed on 8 October 2020. This study’s main outcome is a poor composite outcome, comprising of mortality and severe COVID-19. Results: There were 9 studies with 3663 patients. The prevalence of dyslipidemia in this pooled analysis was 18% (4%-32%). Dyslipidemia was associated with increased composite poor outcome (RR 1.39 [1.02, 1.88], P =.010; I2: 56.7%, P =.018). Subgroup analysis showed that dyslipidemia was associated with severe COVID-19 (RR 1.39 [1.03, 1.87], P =.008; I2: 57.4%, P =.029). Meta-regression showed that the association between dyslipidemia and poor outcome varies by age (coefficient: −0.04, P =.033), male gender (coefficient: −0.03, P =.042), and hypertension (coefficient: −0.02, P =.033), but not diabetes (coefficient: −0.24, P =.135) and cardiovascular diseases (coefficient: −0.01, P =.506). Inverted funnel-plot was relatively symmetrical. Egger’s test indicates that the pooled analysis was not statistically significant for small-study effects (P =.206). Conclusion: Dyslipidemia potentially increases mortality and severity of COVID-19. The association was stronger in patients with older age, male, and hypertension. PROSPERO Registration Number: CRD42020213491 © The Author(s) 2021. |
coronavirus; COVID-19; dyslipidemia; hyperlipidemia; prognosis |
Article; comorbidity; coronavirus disease 2019; diabetes mellitus; disease association; disease severity; dyslipidemia; human; hypertension; infection risk; mortality; prevalence; prognosis; risk assessment; systematic review |
SAGE Publications Ltd |
11795514 |
|
|
Article |
Q3 |
527 |
9598 |
|
|
851 |
Yunir E., Kurniawan F., Rezaprasga E., Wijaya I.P., Suroyo I., Matondang S., Irawan C., Soewondo P. |
36520254800;57202309006;57222478699;57193731572;57204106272;57192085914;28767651600;23475336100; |
Autologous Bone-Marrow vs. Peripheral Blood Mononuclear Cells Therapy for Peripheral Artery Disease in Diabetic Patients |
2021 |
International Journal of Stem Cells |
14 |
1 |
|
21 |
32 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102786540&doi=10.15283%2fijsc20088&partnerID=40&md5=91f35aa55f974c266100f150613cc086 |
Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Yunir, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Kurniawan, F., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Rezaprasga, E., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Wijaya, I.P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Suroyo, I., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Matondang, S., Department of Radiology, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Irawan, C., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Soewondo, P., Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia, Metabolic Disorder, Cardiovascular, and Aging Cluster, Indonesian Medical Education and Research Institute, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
Diabetes mellitus (DM) remains one of the most important risk factors for peripheral artery disease (PAD), with approximately 20% of DM patients older than 40 years old are affected with PAD. The current standard management for severe PAD is endovascular intervention with or without surgical bypass. Unfortunately, up to 40% of patients are unable to undergo these revascularization therapies due to excessive surgical risk or adverse vascular side effects. Stem cell therapy has emerged as a novel therapeutic strategy for these ‘no-option’ patients. Several types of stem cells are utilized for PAD therapy, including bone marrow mononuclear cells (BMMNC) and peripheral blood mononuclear cells (PBMNC). Many studies have reported the safety of BMMNC and PBMNC, as well as its efficacy in reducing ischemic pain, ulcer size, pain-free walking distance, ankle-brachial index (ABI), and transcutaneous oxygen pressure (TcPO2). However, the capacity to establish the efficacy of reducing major amputation rates, amputation free survival, and all-cause mortality is limited, as shown by several randomized placebo-controlled trials. The present literature review will focus on comparing safety and efficacy between BMMNC and PBMNC as cell-based management in diabetic patients with PAD who are not suitable for revascularization therapy. Copyright © 2021 by the Korean Society for Stem Cell Research |
Bone marrow mononuclear cells; Diabetes mellitus; Peripheral artery disease; Peripheral blood mononuclear cells; Stem cell therapy |
Article; autologous bone marrow transplantation; bone marrow derived mononuclear cell; clinical trial (topic); comparative effectiveness; diabetes mellitus; diabetic patient; human; patient safety; peripheral blood mononuclear cell; peripheral occlusive artery disease; stem cell transplantation |
Sungkyunkwan University |
20053606 |
|
|
Article |
Q4 |
569 |
8885 |
|
|
856 |
Rinaldi I., Louisa M., Sari R.M., Arwanih E. |
23475122400;41461551400;57208474079;57222314110; |
Flt3-itd mutation and flt3 ligand plasma level were not associated with one-year survival of Indonesian acute myeloid leukemia patients |
2021 |
OncoTargets and Therapy |
14 |
|
|
1479 |
1486 |
|
1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85102287355&doi=10.2147%2fOTT.S282842&partnerID=40&md5=67e8a263fb7385921e3a50606454ebd6 |
Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Rinaldi, I., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Sari, R.M., Division of Hematology and Medical Oncology, Department of Internal Medicine, Dharmais Cancer Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Arwanih, E., Division of Hematology and Medical Oncology, Department of Internal Medicine, Cipto Mangunkusumo National General Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Objective: To analyze the association of FLT3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian acute myeloid leukemia (AML) patients. Methods: A prospective cohort study was conducted to determine the association between FLT-3-ITD mutation and FLT3 ligand plasma level with one-year survival of Indonesian AML patients. In the study, a total of 51 AML patients were obtained from two tertiary hospitals in Indonesia from year 2018 to 2020. Inclusion criteria were de novo AML male and female patients aged ≥18 years old. Exclusion criteria were prior myelodysplastic syndrome and patients that refused to participate in the study. FLT3-ITD genotype of patients was then analyzed using PCR method while FLT3 ligand plasma level was measured using ELISA method. Patients were then followed-up for 1 year or until death occurred with survival as the measured outcome. Association between independent and dependent variable were analyzed by cox regression proportional hazard. Results: Eleven patients (21.5%) in this study had FLT3-ITD mutation. The median age of AML patients was 45 (18–71) years, and the median blast percentage was 50% (5–87%). After one-year follow-up, 33 (64.7%) patients had died. The median survival of AML patients was 6 months. Univariate analysis showed no association between FLT3-ITD mutation status (HR: 1.051; 95% CI: 0.483–2.286; P: 0.901) and FLT3 ligand plasma level (HR: 0.798; 95% CI: 0.347–1.837; p= 0.596), and age (HR: 1.283; 95% CI: 0.575–2.862; p= 0.542) with one-year survival of AML patients, but multivariate analysis showed association between GFR with one-year survival of AML patients in this cohort (HR: 4.053; 95% CI: 1.469–11.183; p= 0.007). Conclusion: One-year survival of AML patients in Indonesia is not affected by FLT3-ITD mutation and FLT3 ligand plasma level. However, GFR showed association with one-year survival of AML patient in this cohort study. © 2021 Rinaldi et al. |
Acute myeloid leukemia; FLT3 Ligand Plasma; FLT3-ITD; One-year survival |
Flt3 ligand; acute myeloid leukemia; adult; age; aged; Article; cancer survival; clinical feature; cohort analysis; comparative study; controlled study; enzyme linked immunosorbent assay; female; follow up; gene mutation; genetic association; genotype; human; Indonesian; kidney function; major clinical study; male; myelodysplastic syndrome; outcome assessment; overall survival; polymerase chain reaction; prevalence; prospective study; protein blood level; survival time |
Dove Medical Press Ltd |
11786930 |
|
|
Article |
Q2 |
1054 |
4053 |
|
|
873 |
Rosdiana D.S., Setiabudy R., Andalusia R., Gatot D., Louisa M., Bardosono S., Instiaty I. |
56955579800;6602316235;57191278723;6508292159;41461551400;21933841000;55703138400; |
Tpmt genetic variability and its association with hematotoxicity in indonesian children with acute lymphoblastic leukemia in maintenance therapy |
2021 |
Pharmacogenomics and Personalized Medicine |
14 |
|
|
199 |
210 |
|
2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101168492&doi=10.2147%2fPGPM.S288988&partnerID=40&md5=45069dfc59e995d12723c15428e48bcd |
Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dharmais National Cancer Hospital, Jakarta, Indonesia; Drug Registration Directorate, National Agency for Drug and Food Control, Jakarta, Indonesia; Division of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia |
Rosdiana, D.S., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setiabudy, R., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Andalusia, R., Dharmais National Cancer Hospital, Jakarta, Indonesia, Drug Registration Directorate, National Agency for Drug and Food Control, Jakarta, Indonesia; Gatot, D., Division of Hematology-Oncology, Department of Pediatrics, Faculty of Medicine, Universitas Indonesia/Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Bardosono, S., Department of Nutrition, Faculty of Medicine, University of Indonesia, Jakarta, Indonesia; Instiaty, I., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: Hematotoxicity monitoring in children with acute lymphoblastic leukemia (ALL) is critical to preventing life-threatening infections and drug discontinuation. The primary drug that causes hematotoxicity in ALL children is 6-mercaptopurine (6-MP). Genetic variability of the drug-metabolizing enzymes of 6-MP, thiopurine S-methyltransferase (TPMT), is one factor that might increase the susceptibility of children to hematotoxicity. The present study aimed to determine the variability in TPMT genotypes and phenotypes and its association with the occurrence of hematotoxicity in ALL children in maintenance therapy. Patients and Methods: A cross-sectional study was conducted at Cipto Mangunkusumo and Dharmais National Cancer Hospital, Jakarta, Indonesia, from June 2017 to October 2018. We included ALL patients, 1–18 years, who were receiving at least one month of 6-MP during maintenance therapy according to the Indonesian protocol for ALL 2013. Direct sequencing was used to determine TPMT*3A, *3B, and *3C genotypes, and LCMS/MS analysis was performed to measure the plasma concentrations of 6-MP and its metabolites. Association analysis between the TPMT genotype and hematotoxicity was evaluated using the unpaired t-test or Mann–Whitney’s test. Results: The prevalence of neutropenia, anemia, and thrombocytopenia in ALL children during maintenance therapy was 51.9%, 44.3%, and 6.6%, respectively. We found a low frequency of TPMT*3C, which is 0.95%. No association was found between hematotoxicity and TPMT genotypes or age, nutritional status, serum albumin levels, risk stratification, the daily dose of 6-MP, and cotrimoxazole co-administration. However, hematotoxicity was associated with 6-methylmercaptopurine (6-MeMP) plasma concentrations and the ratio 6-MeMP/6-thioguanine (6-TGN). We also found no association between TPMT genotypes and TPMT phenotypes. Conclusion: The 6-MeMP/6-TGN ratio is associated with hematotoxicity in ALL children during maintenance therapy but is not strong enough to predict hematotoxicity. © 2021 Rosdiana et al. |
Mercaptopurine; Methylmercaptopurine; Neutropenia; Thioguanine; Thiopurine methyltransferase |
6 methylthioinosine; albumin; cotrimoxazole; dexamethasone; methotrexate; thiopurine methyltransferase; tioguanine; vincristine; acute lymphoblastic leukemia; adolescent; adult; albumin blood level; anemia; Article; blood toxicity; child; cross-sectional study; drug blood level; drug safety; female; gene sequence; genetic variability; groups by age; human; human cell; Indonesia; Indonesian; liquid chromatography-mass spectrometry; maintenance therapy; major clinical study; male; neutropenia; nutritional status; prevalence; risk factor; thrombocytopenia; TPMT gene |
Dove Medical Press Ltd |
11787066 |
|
|
Article |
Q2 |
845 |
5609 |
|
|
895 |
Tarigan T.J.E., Dwijayanti A., Setyowati S., Louisa M. |
36057746500;55743787900;54893136300;41461551400; |
Immunogenicity and efficacy of insulin glargine biosimilar ezelin versus originator insulin glargine in patients with type 2 diabetes |
2021 |
Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy |
14 |
|
|
107 |
116 |
|
|
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85099828801&doi=10.2147%2fDMSO.S279385&partnerID=40&md5=4adefbb901a3483328866d6334ab8e3d |
Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Tarigan, T.J.E., Division of Endocrinology and Metabolism, Department of Internal Medicine, Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Dwijayanti, A., Department of Medical Pharmacy, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Setyowati, S., Division of Endocrinology, Department of Internal Medicine, Gatot Soebroto Presidential Hospital, Jakarta, Indonesia; Louisa, M., Department of Pharmacology and Therapeutics, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Purpose: To compare the immunogenicity and efficacy of insulin glargine biosimilar Ezelin (EZL) versus originator insulin glargine Lantus (LAN) as a reference basal insulin in patients with type 2 diabetes (T2D). Patients and Methods: This was a randomized, multicenter, open-label, 24-week study in insulin-naïve patients with T2D, with HbA1c of >7.0%. We randomly assigned 133 eligible patients to receive either EZL or LAN. Baseline characteristics, including insulin autoantibody (IAA), zinc transporter 8 (ZnT8) antibody, HbA1C, fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), AST, ALT, BUN, eGFR, and oral antidiabetic drugs, were obtained before starting insulin treatment. After starting treatment, insulin dose was titrated to achieve FPG target along with oral antidiabetic drugs. Patients were given home glucometer and assisted to record plasma glucose measurement and adverse event (AE). Every month, patients came to the diabetes clinic and performed a regular physical examination and intensifying treatment if needed. Out of the 133 randomized patients, only 122 completed the study and can be examined for their IAA and ZnT8 after 6 months of treatment. The study was registered in clinicaltrials.gov, NCT03352674. Results: There is a similar proportion of patients with changes of IAA from baseline: 1 out of 58 (1.7%) patients receiving EZL versus 1 out of 64 (1.6%) patients receiving LAN (p = 1.000). One patient in the EZL group (1.7%) versus none in the LAN group experienced a change of ZnT8 antibody from baseline. Similar glucose control in EZL versus LAN was determined by the change in HbA1c, FPG, and 2hPPG (−2.0%, −67.46 mg/dL, and −76.51 mg/dL in the EZL group versus −1.7%, −58.11 mg/dL, and −70.03 mg/dL in the LAN group). There were six events of documented hypoglycemia in the EZL group versus five events in the LAN group. No patients experienced diabetic ketoacidosis during the study. Conclusion: Overall, insulin glargine biosimilar EZL and originator insulin glargine LAN have shown a similar immunogenicity profile, as well as efficacy in providing glucose control and safety findings in T2D populations. © 2021 Tarigan et al. |
Biosimilar; Hyperglycemia; Insulin autoantibody; Zinc transporter 8 antibody |
acarbose; alanine aminotransferase; aspartate aminotransferase; ezelin; glucose; hemoglobin A1c; insulin antibody; insulin glargine; metformin; pioglitazone; protein antibody; sulfonylurea; unclassified drug; urea; zinc transporter 8; zinc transporter 8 antibody; acute gastroenteritis; acute kidney failure; adult; alanine aminotransferase blood level; Article; aspartate aminotransferase blood level; Bell palsy; cardiovascular disease; cerebrovascular accident; cervical spine fracture; controlled study; coughing; dermatitis; diabetic ketoacidosis; diabetic patient; diabetic ulcer; diarrhea; drug dose titration; drug efficacy; drug safety; dyspepsia; dyspnea; estimated glomerular filtration rate; fasting; female; gangrene; gastritis; gastroesophageal reflux; gastrointestinal symptom; glucose |
Dove Medical Press Ltd |
11787007 |
|
|
Article |
Q2 |
853 |
5525 |
|
|