No records
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332 |
Faisal H.K.P., Taufik F.F., Sugihen T.T.G., Prasenohadi, Juliani T., Yunus F. |
57216393050;57193061752;57226081615;55758911100;57226064151;57194486277; |
Brief psychotic disorder in COVID-19 patient with no history of mental illness |
2021 |
Journal of Infection in Developing Countries |
15 |
6 |
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787 |
790 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110348248&doi=10.3855%2fjidc.14830&partnerID=40&md5=12676e465ecf6e71d13eea343a7e6c3f |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Department of Psychiatry, Persahabatan Hospital, Jakarta, Indonesia |
Faisal, H.K.P., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Taufik, F.F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Sugihen, T.T.G., Department of Psychiatry, Persahabatan Hospital, Jakarta, Indonesia; Prasenohadi, Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Juliani, T., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia; Yunus, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, University of Indonesia - Persahabatan Hospital, Jakarta, Indonesia |
Introduction: COVID-19 pandemic affects mental health globally. Reports showed the increase of mental illness as a response to the COVID-19 pandemic. However, the correlation between the COVID-19 and mental illness is not fully understood yet. Methodology: We reported a brief psychotic disorder in a COVID-19 patient with no history of mental illness who was hospitalized in Persahabatan Hospital, Jakarta, Indonesia. Results: Psychotic symptoms appeared five days after COVID-19 onset and laboratory tests showed elevated levels of d-dimer and fibrinogen. Conclusions: Elevated levels of d-dimer and fibrinogen suggest an ongoing COVID-19-associated coagulopathy that might cause a microdamage in the central nervous system. It might contribute to the manifestation of psychotic symptoms. The correlation between brief psychotic disorder and COVID-19 requires further investigation. Copyright © 2021 Faisal et al. This is an open-access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
Acute psychosis; Brief psychotic disorder; COVID-19; Neuropsychiatry |
alanine aminotransferase; amlodipine; ascorbic acid; aspartate aminotransferase; azithromycin; bicarbonate; C reactive protein; creatinine; D dimer; enoxaparin; ferritin; hemoglobin; hydroxychloroquine; lorazepam; oseltamivir; potassium; risperidone; sodium; urea; vitamin D; fibrin degradation product; fibrin fragment D; fibrinogen; activated partial thromboplastin time; adult; Article; auditory hallucination; blood carbon dioxide tension; blood oxygen tension; brief psychotic disorder; case report; clinical article; cold sweat; computer assisted tomography; coronavirus disease 2019; diarrhea; dry cough; dyspnea; glucose blood level; human; hypertension; lymphocyte count; male; medical history; middle aged; nasopharyngeal swab; neutrophil count; platelet count; prothrombin time; reverse tr |
Journal of Infection in Developing Countries |
20366590 |
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34242187 |
Article |
Q3 |
322 |
14136 |
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348 |
Djuardi Y., Lazarus G., Stefanie D., Fahmida U., Ariawan I., Supali T. |
6507800820;57214599425;57193121018;14420783500;8840573400;6602742029; |
Soil-transmitted helminth infection, anemia, and malnutrition among preschool-age children in nangapanda subdistrict, indonesia |
2021 |
PLoS Neglected Tropical Diseases |
15 |
6 |
e0009506 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85110433985&doi=10.1371%2fjournal.pntd.0009506&partnerID=40&md5=acf6b372e3919f6422f75ae7d13a1c91 |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia |
Djuardi, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lazarus, G., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Stefanie, D., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Fahmida, U., Southeast Asian Ministers of Education Organization Regional Centre for Food and Nutrition (SEAMEO RECFON), Pusat Kajian Gizi Regional Universitas Indonesia, Jakarta, Indonesia; Ariawan, I., Department of Biostatistics and Population Studies, Faculty of Public Health, Universitas Indonesia, Depok, Indonesia; Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia |
Background Soil-transmitted helminth (STH) infections are still prevalent in Indonesia, with roughly one-third of infected population being preschool-age children (PSC), which are generally at higher risk of morbidity such as malnutrition and anemia. This study aimed to investigate the association of STH infections with nutritional status and anemia among PSC in Nangapanda subdistrict, Ende, East Nusa Tenggara. Methods A cross-sectional survey involving PSC ranging from 12 to 59 months old from Nangapanda subdistrict, Ende district, East Nusa Tenggara was performed. Socio-demographic, breastfeeding, and complementary feeding information was obtained from structured questionnaires, while nutritional and anemia status was determined from anthropometry and hemoglobin measurements, respectively. Anthropometric z-scores were calculated based on the World Health Organization 2006 standards and stool samples were examined using Kato-Katz method. Results A total of 393 PSC randomly selected from 22 villages were examined. The prevalence of underweight, stunting, wasting, and anemia were 33.1%, 40.2%, 17.1%, and 60.3%, respectively. STH infection, predominated by Ascaris lumbricoides, was found in 160 (58.8%) PSC. Single STH infection, but not multiple infection, was independently associated with a lower risk of anemia (odds ratio [OR] 0.320, 95% confidence interval [CI]: 0.126– 0.809, p = 0.016). Similar association with anemia was also found on mild STH infection (OR 0.318 [95% CI: 0.114–0.887], p = 0.029). On the other hand, younger children were found to have a higher risk of anemia and stunting. None of the examined variables were independently associated with underweight and wasting. Conclusion STH infection as well as anemia and malnutrition were prevalent in this region. However in this study, current STH infections seemed to have minimal negative impact on children’s nutritional status. © 2021 Djuardi et al. |
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edetic acid; hemoglobin; hemoglobin; anemia; anthropometry; antiretroviral therapy; Article; body mass; breast feeding; child; complementary feeding; controlled study; cross-sectional study; disorder of sex development; endoscopic retrograde cholangiopancreatography; feces analysis; female; flotation; food frequency questionnaire; food intake; helminthiasis; human; major clinical study; male; malnutrition; mass spectrometry; morbidity; nutritional status; obesity; preschool child; questionnaire; randomized controlled trial; risk factor; Strongyloides stercoralis; structured questionnaire; stunting; underweight; vitamin intake; vitamin supplementation; World Health Organization; anemia; animal; Ascaris lumbricoides; growth disorder; helminthiasis; Indonesia; infant; malnutrition; parasitolo |
Public Library of Science |
19352727 |
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34138863 |
Article |
Q1 |
1990 |
1322 |
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349 |
Shukla A., Shreshtha A., Mukund A., Bihari C., Eapen C.E., Han G., Deshmukh H., Cua I.H.Y., Lesmana C.R.A., Al Meshtab M., Kage M., Chaiteeraki R., Treeprasertsuk S., Giri S., Punamiya S., Paradis V., Qi X., Sugawara Y., Abbas Z., Sarin S.K. |
36652088000;57225888142;15071187800;49860931800;7003684081;24741087200;7003527959;7801457234;8977683000;57225918379;57225886245;57225920095;57077082800;57221051314;23670642900;57195572516;35339923000;57197741618;35572268700;57220191468; |
Budd-Chiari syndrome: consensus guidance of the Asian Pacific Association for the study of the liver (APASL) |
2021 |
Hepatology International |
15 |
3 |
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531 |
567 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85109622410&doi=10.1007%2fs12072-021-10189-4&partnerID=40&md5=727d2318980fa73306867439390cc762 |
Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Alka Hospital, Kathmandu, Nepal; Institute of Liver and Biliary Sciences, New Delhi, India; Christian Medical College, Vellore, India; Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia; Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh; Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan |
Shukla, A., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Shreshtha, A., Alka Hospital, Kathmandu, Nepal; Mukund, A., Institute of Liver and Biliary Sciences, New Delhi, India; Bihari, C., Institute of Liver and Biliary Sciences, New Delhi, India; Eapen, C.E., Christian Medical College, Vellore, India; Han, G., Xijing Hospital of Digestive Diseases, Fourth Military Medical University, Xian, China; Deshmukh, H., Dean and Head of Radiology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Cua, I.H.Y., Institute of Digestive and Liver Diseases, St Lukes Medical Center, Global City, Philippines; Lesmana, C.R.A., Dr. Cipto Mangunkusumo National General Hospital, Universitas Indonesia, Jakarta, Indonesia, Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia; Al Meshtab, M., Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, Center for Innovative Cancer Therapy, Kurume University Research, 67 Asahi-machi, Kurume, 830-0011, Japan; Kage, M., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Chaiteeraki, R., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Treeprasertsuk, S., Division of Gastroenterology, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand; Giri, S., Department of Gastroenterology, King Edward Memorial Hospital and Seth Gordhandas Sunderdas Medical College, Mumbai, India; Punamiya, S., Vascular and Interventional Radiology, Tan Tock Seng Hospital, Singapore, Singapore; Paradis, V., Dpt dAnatomie Pathologique, Hôpital Beaujon, 100 bd du Gal Leclerc, Clichy, 92110, France; Qi, X., General Hospital of Northern Theater Command (formerly General Hospital of Shenyang Military Area), No. 83 Wenhua Road, Shenyang, China; Sugawara, Y., Department of Transplantation and Pediatric Surgery, Kumamoto University, Kumamoto, Japan; Abbas, Z., Department of Hepatogastroenterology, Dr. Ziauddin University Hospital Clifton, Karachi, Pakistan; Sarin, S.K., Institute of Liver and Biliary Sciences, New Delhi, India |
Budd Chiari syndrome (BCS) is a diverse disease with regard to the site of obstruction, the predisposing thrombophilic disorders and clinical presentation across the Asia-Pacific region. The hepatic vein ostial stenosis and short segment thrombosis are common in some parts of Asia-Pacific region, while membranous obstruction of the vena cava is common in some and complete thrombosis of hepatic veins in others. Prevalence of myeloproliferative neoplasms and other thrombophilic disorders in BCS varies from region to region and with different sites of obstruction. This heterogeneity also raises several issues and dilemmas in evaluation and approach to management of a patient with BCS. The opportunity to recanalize hepatic vein in patients with hepatic vein ostial stenosis or inferior vena cava stenting or pasty among those membranous obstruction of the vena cava is a unique opportunity in the Asia–Pacific region to restore hepatic outflow closely mimicking physiology. In order to address these issues arising out of the diversity as well as the unique features in the region, the Asia Pacific Association for Study of Liver has formulated these guidelines for clinicians. © 2021, Asian Pacific Association for the Study of the Liver. |
Ascites; Budd Chiari syndrome; Hepatic vein stenting; Hepatocellular carcinoma; HVOTO; Liver biopsy; Liver transplant; MOVC; Portal hypertension; TIPS |
calreticulin; low molecular weight heparin; acute liver failure; acute on chronic liver failure; angioplasty; anticoagulant therapy; Article; Asia; blood clot lysis; blood clotting; Budd Chiari syndrome; cancer chemotherapy; chemoembolization; clinical feature; computer assisted tomography; Doppler flowmetry; female fertility; follow up; groups by age; hepatocellular adenoma; human; hyperhomocysteinemia; incidence; inferior cava vein; liver adenoma; liver cell carcinoma; liver nodule; liver transplantation; liver vein; nodular hyperplasia; nuclear magnetic resonance imaging; pathogenesis; postoperative complication; practice guideline; pregnancy; preoperative evaluation; prognosis; recanalization; risk factor; stent thrombosis; survival factor; thrombophilia; transjugular intrahepatic port |
Springer |
19360533 |
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34240318 |
Article |
Q2 |
1304 |
2874 |
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417 |
Yunir E., Soewondo P., Soelistijo S.A., Rudijanto A. |
36520254800;23475336100;57211324846;23499422500; |
Knowledge and behavior changes in clinician after training of partnership for Diabetes Control in Indonesia |
2021 |
Diabetes and Metabolic Syndrome: Clinical Research and Reviews |
15 |
3 |
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719 |
724 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103636919&doi=10.1016%2fj.dsx.2021.03.012&partnerID=40&md5=69390ed0f1d97f773993433ca4e7d1d0 |
Division of Endocrinology and Metabolism, Department of Internal Medicine Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Surabaya Diabetes and Nutrition Centre, Department of Internal Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Surabaya, 60132, Indonesia; Division of Endocrinology and Metabolism, Department of Internal Medicine, Universitas Brawijaya, Jl. Veteran Malang, Malang, 65145, Indonesia |
Yunir, E., Division of Endocrinology and Metabolism, Department of Internal Medicine Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Soewondo, P., Division of Endocrinology and Metabolism, Department of Internal Medicine Dr. Cipto Mangunkusumo National Referral Hospital, Faculty of Medicine Universitas Indonesia, Jl. Diponegoro No.71, Central Jakarta, 10430, Indonesia; Soelistijo, S.A., Surabaya Diabetes and Nutrition Centre, Department of Internal Medicine, Universitas Airlangga, Jl. Mayjen Prof. Dr. Moestopo No.47, Surabaya, 60132, Indonesia; Rudijanto, A., Division of Endocrinology and Metabolism, Department of Internal Medicine, Universitas Brawijaya, Jl. Veteran Malang, Malang, 65145, Indonesia |
Background and aims: One of the main determinants of successful diabetes management is the quality of healthcare provider including general practitioner and internist which can be increased through medical training. This study aimed to describe the changes of clinician's knowledge and behavior of comprehensive diabetes management training program around Indonesia. Method: We conducted a three-day training program for general practitioners and internists for 3.5 years, 2013 to 2016. All clinicians invited as voluntary participant to send their patient data from medical record. Each participant was expected to submit a minimum of 25 type 2 diabetes (T2DM) set patient data before and 6 months after training program to analyze the impact of program in physician knowledge and behavior related to diabetes management. Result: 120 of 489 voluntary participants submitted completed baseline data with 4676 patient data. Meanwhile, only 32 participants that submitted completed data of 6 months before after training with 886 patient data. Most of parameters were improve before and after program. The greatest and lowest improvement were on A1c measurement (21%) and smoking assessment (2%). Conclusion: Intensive seminar and training was not enough to empower diabetes management. This research might push the creation of clinical practice program that were tailored to each care facilities and integrated within routine care aimed at continual improvement of its healthcare worker. © 2021 |
Behavior; Diabetes; Knowledge; Training |
fibric acid derivative; hemoglobin A1c; antidiabetic agent; biological marker; glycosylated hemoglobin; hemoglobin A1c protein, human; adult; aged; Article; behavior; behavior change; controlled study; diabetes control; diabetes mellitus; diabetic complication; female; general practitioner; health personnel attitude; human; Indonesia; internist; major clinical study; male; medical education; middle aged; non insulin dependent diabetes mellitus; patient coding; priority journal; retrospective study; smoking; young adult; attitude to health; blood; clinical competence; education; follow up; glucose blood level; health care personnel; internal medicine; medical education; non insulin dependent diabetes mellitus; procedures; professional practice; prognosis; psychology; Adult; Aged; Biomarkers |
Elsevier Ltd |
18714021 |
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33813247 |
Article |
Q2 |
684 |
7304 |
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419 |
Iwai M., Tulafu M., Togo S., Kawaji H., Kadoya K., Namba Y., Jin J., Watanabe J., Okabe T., Hidayat M., Sumiyoshi I., Itoh M., Koyama Y., Ito Y., Orimo A., Takamochi K., Oh S., Suzuki K., Hayashizaki Y., Yoshida K., Takahashi K. |
56357096800;55818028100;9533914900;57196621148;57193562606;55413965500;57221345975;57202019639;57208252941;56435992700;57202003876;57218355452;57202921569;57225926629;56922531400;57070836300;56922435100;57221017119;57216108710;55725231300;57226207751; |
Cancer-associated fibroblast migration in non-small cell lung cancers is modulated by increased integrin α11 expression |
2021 |
Molecular Oncology |
15 |
5 |
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1507 |
1527 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103164588&doi=10.1002%2f1878-0261.12937&partnerID=40&md5=b2e053e6ecbd024c8cbcf42081179238 |
Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan; Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan |
Iwai, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Tulafu, M., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Togo, S., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Kawaji, H., Tokyo Metropolitan Institute of Medical Science, Setagaya-ku, Japan, Preventive Medicine and Applied Genomics Unit, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan, RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Kadoya, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Namba, Y., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Jin, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Respiratory and Critical Care Medicine, National Center of Gerontology, Beijing Hospital, China; Watanabe, J., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Okabe, T., Leading Center for the Development and Research of Cancer Medicine, Juntendo University, Tokyo, Japan; Hidayat, M., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan, Department of Pulmonology and Respiratory Medicine, Universitas Indonesia Faculty of Medicine, Jakarta, Indonesia; Sumiyoshi, I., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan; Itoh, M., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Koyama, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan, Department of Oral Pathobiological Science and Surgery, Tokyo Dental College, Japan; Ito, Y., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Orimo, A., Departments of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan; Takamochi, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Oh, S., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Suzuki, K., Department of General Thoracic Surgery, Juntendo University School of Medicine, Tokyo, Japan; Hayashizaki, Y., RIKEN Preventive Medicine and Diagnosis Innovation Program, Saitama, Japan; Yoshida, K., Faculty of Biology-Oriented Science and Technology, Kindai University, Wakayama, Japan; Takahashi, K., Division of Respiratory Medicine, Juntendo University Faculty of Medicine & Graduate School of Medicine, Tokyo, Japan |
Cancer-associated fibroblasts (CAFs) regulate cancer progression through the modulation of extracellular matrix (ECM) and cancer cell adhesion. While undergoing a series of phenotypic changes, CAFs control cancer–stroma interactions through integrin receptor signaling. Here, we isolated CAFs from patients with non-small-cell lung cancer (NSCLC) and examined their gene expression profiles. We identified collagen type XI α1 (COL11A1), integrin α11 (ITGA11), and the ITGA11 major ligand collagen type I α1 (COL1A1) among the 390 genes that were significantly enriched in NSCLC-associated CAFs. Increased ITGA11 expression in cancer stroma was correlated with a poor clinical outcome in patients with NSCLC. Increased expression of fibronectin and collagen type I induced ITGA11 expression in CAFs. The cellular migration of CAFs toward collagen type I and fibronectin was promoted via ERK1/2 signaling, independently of the fibronectin receptor integrin α5β1. Additionally, ERK1/2 signaling induced ITGA11 and COL11A1 expression in cancer stroma. We, therefore, propose that targeting ITGA11 and COL11A1 expressing CAFs to block cancer–stroma interactions may serve as a novel, promising anti-tumor strategy. © 2021 The Authors. Molecular Oncology published by John Wiley & Sons Ltd on behalf of Federation of European Biochemical Societies. |
cancer; cancer-associated fibroblast; collagen type I; collagen type XI α1; integrin alpha-11; non-small-cell lung cancer; stroma interaction; transforming growth factor beta |
alpha11 integrin; collagen type 1; collagen type 1 alpha1; collagen type 11; collagen type 11 alpha1; fibronectin; fibronectin receptor; integrin; mitogen activated protein kinase 3; retrovirus vector; small interfering RNA; transforming growth factor beta1; unclassified drug; very late activation antigen 5; adult; aged; Article; cancer associated fibroblast; cancer recurrence; cell interaction; cell migration; chemotaxis; clinical article; clinical outcome; controlled study; DNA modification; enzyme linked immunosorbent assay; female; gene expression profiling; human; human cell; human tissue; immunohistochemistry; in vitro study; lung adenocarcinoma; lung fibroblast; lung parenchyma; male; non small cell lung cancer; priority journal; protein expression; protein expression level; protein |
John Wiley and Sons Ltd |
15747891 |
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33682233 |
Article |
Q1 |
2332 |
1019 |
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455 |
Wang G., Tanaka A., Zhao H., Jia J., Ma X., Harada K., Wang F.-S., Wei L., Wang Q., Sun Y., Hong Y., Rao H., Efe C., Lau G., Payawal D., Gani R., Lindor K., Jafri W., Omata M., Sarin S.K. |
7407149871;57208572262;57200532284;57218488345;7404550067;57212924064;57216339526;7402950828;55531131800;56402234600;57188750283;8220686600;25122065500;36114075400;7801385732;23495930300;35418813000;23091123700;36043368300;57220191468; |
The Asian Pacific Association for the Study of the Liver clinical practice guidance: the diagnosis and management of patients with autoimmune hepatitis |
2021 |
Hepatology International |
15 |
2 |
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223 |
257 |
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7 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85105607533&doi=10.1007%2fs12072-021-10170-1&partnerID=40&md5=eef4f926d521f19ad391095aa3af27f0 |
Peking University First Hospital, Beijing, China; Teikyo University School of Medicine, Tokyo, Japan; Beijing Friendship Hospital, Capital Medical University, Beijing, China; Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Kanazawa, Japan; Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Beijing Tsinghua Changgung Hospital, Beijing, China; Peking University People’s Hospital, Beijing, China; Department of Gastroenterology, Harran University, Åžanlıurfa, Turkey; Humanity and Health Medical Group, Hong Kong; Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines; Department of Internal Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; College of Health Solutions, Arizona State University, Phoenix, AZ, United States; Aga Khan University, Karachi, Pakistan; Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Kofu-City, Yamanashi, Japan; The University of Tokyo, Tokyo, Japan; Institute of Liver and Biliary Sciences, New Delhi, India; Peking University International Hospital, Beijing, China |
Wang, G., Peking University First Hospital, Beijing, China, Peking University International Hospital, Beijing, China; Tanaka, A., Teikyo University School of Medicine, Tokyo, Japan; Zhao, H., Peking University First Hospital, Beijing, China, Peking University International Hospital, Beijing, China; Jia, J., Beijing Friendship Hospital, Capital Medical University, Beijing, China; Ma, X., Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Harada, K., Department of Human Pathology, Kanazawa University Graduate School of Medicine Kanazawa, Kanazawa, Japan; Wang, F.-S., Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Wei, L., Beijing Tsinghua Changgung Hospital, Beijing, China; Wang, Q., Shanghai Institute of Digestive Disease, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China; Sun, Y., Fifth Medical Center, Chinese PLA General Hospital, Beijing, China; Hong, Y., Peking University First Hospital, Beijing, China; Rao, H., Peking University People’s Hospital, Beijing, China; Efe, C., Department of Gastroenterology, Harran University, Åžanlıurfa, Turkey; Lau, G., Humanity and Health Medical Group, Hong Kong; Payawal, D., Department of Hepatology, Cardinal Santos Medical Center, Manila, Philippines; Gani, R., Department of Internal Medicine, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia; Lindor, K., College of Health Solutions, Arizona State University, Phoenix, AZ, United States; Jafri, W., Aga Khan University, Karachi, Pakistan; Omata, M., Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Kofu-City, Yamanashi, Japan, The University of Tokyo, Tokyo, Japan; Sarin, S.K., Institute of Liver and Biliary Sciences, New Delhi, India |
[No abstract available] |
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6 mercaptopurine derivative; azathioprine; budesonide; corticosteroid; cyclosporine; farnesoid X receptor; infliximab; mycophenolate mofetil; prednisone; rapamycin; tacrolimus; antibody detection; Asia; autoimmune hepatitis; autoimmunity; cataract; chronic liver disease; clinical practice; cytokine production; decompensated liver cirrhosis; diabetes mellitus; disease predisposition; drug efficacy; drug exposure; drug safety; dual energy X ray absorptiometry; environmental factor; gene locus; genetic susceptibility; geographic distribution; human; hypertension; immunoglobulin blood level; immunological tolerance; immunoregulation; incidence; liver biopsy; liver cell carcinoma; liver transplantation; magnetic resonance elastography; nonalcoholic fatty liver; Note; osteoporosis; Pacific islan |
Springer |
19360533 |
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33942203 |
Note |
Q2 |
1304 |
2874 |
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488 |
Djaja Y.P., Prasetia R., Santoso A., Rahyussalim A.J., Mustamsir E., Dilogo I.H. |
57191042059;57196246350;57194659467;55212166100;57196246488;56161962800; |
A decade of evolution in Indonesian orthopedic publication: A bibliographic report |
2021 |
Journal of Clinical Orthopaedics and Trauma |
15 |
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110 |
116 |
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1 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85092623352&doi=10.1016%2fj.jcot.2020.10.016&partnerID=40&md5=54bca8c1ea47f4019dfac052838cc471 |
Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia |
Djaja, Y.P., Department of Orthopedic & Traumatology, Fatmawati General Hospital, Jakarta, Indonesia; Prasetia, R., Faculty of Medicine, Department of Orthopaedic Surgery, Universitas Padjadjaran, Bandung, Indonesia; Santoso, A., Department of Orthopaedic and Traumatology, Sebelas Maret University, Prof Dr R Soeharso Orthopaedic Hospital, Solo, Indonesia; Rahyussalim, A.J., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia; Mustamsir, E., Department of Orthopaedics and Traumatology, Faculty of Medicine Brawijaya University, Saiful Anwar General Hospital, Malang, Indonesia; Dilogo, I.H., Department of Orthopaedic & Traumatology, Cipto Mangunkusumo General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia |
During the past decade, there was an increasing interest in orthopedic research in Indonesia. Therefore we aimed to investigate the profile of Indonesian orthopedic trend publication from 2010 to 2019. Systematic research was conducted to identify all orthopedic articles authored by Indonesian orthopedic surgeons. Article details (number of authors, authors’ affiliation, publishing journal), type of author's affiliation, affiliate collaboration, study field, type, and level of evidence (LOE) were recorded and evaluated. Publishing journal metric and author h-index were also recorded. Descriptive statistics were used to summarize the data. Two hundred and twenty articles were included in our study. Clinical studies were the most common article type, followed by case reports and basic science. Among clinical articles, therapeutic studies were found significantly more frequent. On the other hand, economic studies were not found in this study period. The most popular field was oncology, followed by knee and spine. The average number of authors per article was 5.23 with a total of 205 individuals who had contributed during this decade. University hospital was the most common affiliation found and single-center study was the most common affiliate collaboration. The most common level of evidence was level V (case reports). Eighty-seven specific publishing journals were identified. More than 42% of the articles were published in journals with SJR between 0.25 and 0.50. The average author h-index was 3.56 (0–7). Although there was an increasing trend and quantity of publications among Indonesian authors, most articles had level 5 evidence (case reports) and the quality of publishing journals was mostly Q3 with a low-moderate SJR. Improvement of the article's quality and institutional collaboration will be needed for future contribution in global orthopedic society. © 2020 Delhi Orthopedic Association |
Bibliographic; Indonesia; Orthopedic article; Publication trend |
adult; female; human; human experiment; Indonesia; knee; major clinical study; male; orthopedic surgeon; publishing; review; spine; university hospital |
Elsevier B.V. |
09765662 |
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Review |
Q3 |
471 |
10597 |
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491 |
Susanto A.D., Triyoga P.A., Isbaniah F., Fairuz A., Cendikiawan H., Zaron F., Aryanti I., Irbah S.N., Hidayat M. |
57190425587;57222896246;36489441300;57222895896;57222896833;57222896488;57222896415;57222896232;56435992700; |
Lung fibrosis sequelae after recovery from COVID-19 infection |
2021 |
Journal of Infection in Developing Countries |
15 |
3 |
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360 |
365 |
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3 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85104167707&doi=10.3855%2fjidc.13686&partnerID=40&md5=622edaeb2b1f79f472a58df7a7dfdca2 |
Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Susanto, A.D., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia, Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Triyoga, P.A., Lung Clinic, Eka Hospital Cibubur, West Java, Indonesia; Isbaniah, F., Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Universitas Indonesia-Persahabatan Hospital, Jakarta, Indonesia; Fairuz, A., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Cendikiawan, H., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Zaron, F., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Aryanti, I., Radiology Departement, Eka Hospital Cibubur, West Java, Indonesia; Irbah, S.N., Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Hidayat, M., Faculty of Medicine, University of Mataram, Mataram, West Nusa Tenggara, Indonesia |
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel coronavirus that causes coronavirus diseases 2019 (COVID-19). The SARS-CoV-2 is very contagious and nobody is known to be immune to it. The post-infected lung would leave a scar known as fibrosis, a scar tissue. A study from Wuhan, China suggested the development of fibrosis, though it was too early to label these lung changes as irreversible fibrosis in a time range of 3 weeks. The occurrence of fibrosis indicates a chronic infection which greatly contributes to the hallmark symptom of COVID-19 induced ARDS such as shortness of breath and chest pain. However, many of those studies have not yet explained the condition of the patient's lung after total recovery from the COVID-19. This report demonstrates the clinical symptoms, chest CT scan, spirometry, and blood gas analysis of patient after total recovery from the COVID-19 with appearance lung fibrosis. Copyright © 2021 Susanto et al. |
COVID-19; Lung fibrosis; Recovery |
ascorbic acid plus vitamin B complex; azithromycin; beta 2 adrenergic receptor stimulating agent; chloroquine; corticosteroid; hemoglobin; levofloxacin; meropenem; oseltamivir; adult; adult respiratory distress syndrome; Article; blood gas analysis; breathing rate; case report; cell count; clinical article; computer assisted tomography; coronavirus disease 2019; coughing; dyspnea; fever; forced expiratory volume; forced vital capacity; ground glass opacity; headache; hospitalization; human; lung examination; lung fibrosis; male; middle aged; nose smear; oropharyngeal swab; oxygen saturation; oxygen therapy; physical examination; pneumonia; quality of life; real time polymerase chain reaction; rhinorrhea; Severe acute respiratory syndrome coronavirus 2; spirometry; thorax pain; thorax radio |
Journal of Infection in Developing Countries |
20366590 |
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33839710 |
Article |
Q3 |
322 |
14136 |
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514 |
Chang F.-Y., Wiratman W., Ugawa Y., Kobayashi S. |
57195621810;57191920526;7005460744;56508693300; |
Event-Related Potentials During Decision-Making in a Mixed-Strategy Game |
2021 |
Frontiers in Neuroscience |
15 |
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552750 |
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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103554813&doi=10.3389%2ffnins.2021.552750&partnerID=40&md5=ef31052f38e98dcc5c24224d29264efc |
Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan; Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Department of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan; Department of Neurology, Takeda General Hospital, Fukushima, Japan; Department of Neurology, Teikyo University, Tokyo, Japan |
Chang, F.-Y., Department of Neurology, School of Medicine, Fukushima Medical University, Fukushima, Japan; Wiratman, W., Department of Neurology, Faculty of Medicine, Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia; Ugawa, Y., Department of Human Neurophysiology, Fukushima Medical University, Fukushima, Japan, Department of Neurology, Takeda General Hospital, Fukushima, Japan; Kobayashi, S., Department of Neurology, Teikyo University, Tokyo, Japan |
The decisions we make are sometimes influenced by interactions with other agents. Previous studies have suggested that the prefrontal cortex plays an important role in decision-making and that the dopamine system underlies processes of motivation, motor preparation, and reinforcement learning. However, the physiological mechanisms underlying how the prefrontal cortex and the dopaminergic system are involved in decision-making remain largely unclear. The present study aimed to determine how decision strategies influence event-related potentials (ERPs). We also tested the effect of levodopa, a dopamine precursor, on decision-making and ERPs in a randomized double-blind placebo-controlled investigation. The subjects performed a matching-pennies task against an opposing virtual computer player by choosing between right and left targets while their ERPs were recorded. According to the rules of the matching-pennies task, the subject won the trial when they chose the same side as the opponent, and lost otherwise. We set three different task rules: (1) with the alternation (ALT) rule, the computer opponent made alternating choices of right and left in sequential trials; (2) with the random (RAND) rule, the opponent randomly chose between right and left; and (3) with the GAME rule, the opponent analyzed the subject’s past choices to predict the subject’s next choice, and then chose the opposite side. A sustained medial ERP became more negative toward the time of the subject’s target choice. A biphasic potential appeared when the opponent’s choice was revealed after the subject’s response. The ERPs around the subject’s choice were greater in RAND and GAME than in ALT, and the negative peak was enhanced by levodopa. In addition to these medial ERPs, we observed lateral frontal ERPs tuned to the choice direction. The signals emerged around the choice period selectively in RAND and GAME when levodopa was administered. These results suggest that decision processes are modulated by the dopamine system when a complex and strategic decision is required, which may reflect decision updating with dopaminergic prediction error signals. © Copyright © 2021 Chang, Wiratman, Ugawa and Kobayashi. |
executive function; feedback; game theory; high-density EEG; levodopa; Parkinson’s disease; prefrontal cortex; readiness potential |
dopamine; levodopa; Article; behavior; clinical article; contingent negative variation; controlled study; diffusion weighted imaging; dopaminergic system; electroencephalography; electrophysiology; entropy; event related potential; executive function; female; gray matter; human experiment; local field potential; male; middle aged; normal human; Parkinson disease; prefrontal cortex; randomized controlled trial; social behavior; task performance |
Frontiers Media S.A. |
16624548 |
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Article |
Q2 |
1499 |
2279 |
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527 |
Supali T., Djuardi Y., Christian M., Iskandar E., Alfian R., Maylasari R., Destani Y., Lomiga A., Minggu D., Lew D., Bogus J., Weil G.J., Fischer P.U. |
6602742029;6507800820;57209806543;57202299885;57222748640;57222744651;57222743128;57205724071;57202307524;57196371851;57170558700;7007028568;23567680200; |
An open label, randomized clinical trial to compare the tolerability and efficacy of ivermectin plus diethylcarbamazine and albendazole vs. Diethylcarbamazine plus albendazole for treatment of brugian filariasis in Indonesia |
2021 |
PLoS Neglected Tropical Diseases |
15 |
3 |
e0009294 |
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2 |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103946402&doi=10.1371%2fjournal.pntd.0009294&partnerID=40&md5=bf67e831adfbad446acbda06b08e12de |
Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Universitas Nusa Cendana, Kupang, Lasiana, Kelapa lima, Kota Kupang, Indonesia; Nusa Tenggara Timur Provincial Health Office, Oebobo, Kota Kupang, Nusa Tenggara Timur, Indonesia; Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, United States; Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States |
Supali, T., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Djuardi, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Christian, M., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Iskandar, E., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Alfian, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Maylasari, R., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Destani, Y., Department of Parasitology, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia; Lomiga, A., Universitas Nusa Cendana, Kupang, Lasiana, Kelapa lima, Kota Kupang, Indonesia; Minggu, D., Nusa Tenggara Timur Provincial Health Office, Oebobo, Kota Kupang, Nusa Tenggara Timur, Indonesia; Lew, D., Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, United States; Bogus, J., Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Weil, G.J., Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States; Fischer, P.U., Infectious Diseases Division, Department of Medicine, Washington University School of Medicine, St. Louis, MO, United States |
Improved treatments for lymphatic filariasis (LF) could accelerate the global elimination program for this disease. A triple drug combination of the anti-filarial drugs ivermectin, diethyl-carbamazine (DEC) and albendazole (IDA) has been shown to be safe and effective for achieving sustained clearance of microfilariae (Mf) of the filarial parasite Wuchereria ban-crofti from human blood. However, the triple drug combination has not been previously been evaluated for treatment of brugian filariasis, which accounts for about 10% of the global LF burden. This hospital-based clinical trial compared the safety and efficacy of IDA with that of the standard treatment (DEC plus albendazole, DA) in persons with Brugia timori infections on Sumba island, Indonesia. Fifty-five asymptomatic persons with B. timori Mf were treated with either a single oral dose of IDA (28 subjects) or with DEC plus albendazole (DA, 27 sub-jects). Participants were actively monitored for adverse events (AE) for two days after treatment by nurses and physicians who were masked regarding treatment assignments. Passive monitoring was performed by clinical teams that visited participant’s home villages for an additional five days. Microfilaremia was assessed by membrane filtration of 1 ml night blood at baseline, at 24h and one year after treatment. IDA was more effective than DA for completely clearing Mf at 24 hours (25/28, 89% vs. 8/27, 30%, P < 0.001). By 12 months after treatment, only one of 27 IDA recipients had Mf in their blood (4%) vs. 10 of 25 (40%) in persons treated with DA (P = 0.002). Approximately 90% of participants had antibodies to recombinant filarial antigen BmR1 at baseline. Antibody prevalence decreased to approximately 30% in both treatment groups at 12 months. About 45% of persons in both treatment groups experienced AE such as fever, muscle aches, lower back, joint and abdominal pain. These were mostly mild and most common during the first two days after treatment. No participant experienced a severe or serious AE. This study showed that IDA was well-tolerated and significantly more effective for clearing B. timori Mf from the blood than DA. Larger studies should be performed to further assess the safety and efficacy of IDA as a mass drug administration regimen to eliminate brugian filariasis. © 2021 Supali et al. |
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albendazole; antifilarial agent; diethylcarbamazine; immunoglobulin G4; ivermectin; albendazole; antifilarial agent; diethylcarbamazine; ivermectin; protozoon antibody; abdominal pain; adult; antibody titer; arthralgia; Article; body mass; Brugia; Brugian filariasis; Burkholderia pseudomallei; combination drug therapy; controlled study; coughing; daily life activity; double blind procedure; dried blood spot testing; drowsiness; drug efficacy; drug safety; drug tolerability; female; fever; filariasis; follow up; gametocyte; headache; helminthiasis; human; Indonesia; leprosy; low back pain; lymphatic filariasis; major clinical study; male; mass drug administration; microfilariasis; myalgia; pharmacokinetics; Plasmodium falciparum; prevalence; questionnaire; randomized controlled trial; Schis |
Public Library of Science |
19352727 |
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33780481 |
Article |
Q1 |
1990 |
1322 |
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